uric acid has been researched along with Weight Gain in 45 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous evidence suggests that higher blood uric acid (UA) levels are associated with adverse cardiovascular outcomes during pregnancy and subsequent birth outcomes." | 8.31 | Associations of early pregnancy serum uric acid levels with risk of gestational diabetes and birth outcomes: a retrospective cohort study. ( Chen, GD; Guo, XL; Li, PS; Liu, ZP; Ma, HT; Pang, TT; Shen, XY; Wan, YC; Zhou, ZX, 2023) |
| " Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight." | 8.02 | Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice. ( Akari, S; Katoh, N; Mizukami, H; Murase, T; Nakamura, T; Nampei, M; Satoh, E, 2021) |
| " Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased." | 7.76 | Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010) |
| " To clarify the relations between serum uric acid, plasma norepinephrine, and insulin or leptin levels in subjects with weight gain-induced blood pressure elevation, we conducted the present longitudinal study." | 7.72 | Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. ( Kawaguchi, H; Masuo, K; Mikami, H; Ogihara, T; Tuck, ML, 2003) |
| "The purpose of this study was to evaluate the efficacy and safety of olanzapine for the treatment of acute manic or mixed episodes associated with bipolar disorder in adolescents." | 5.12 | Olanzapine versus placebo in the treatment of adolescents with bipolar mania. ( Biederman, J; Carlson, G; Delbello, M; Dittmann, RW; Findling, R; Kowatch, R; Kryzhanovskaya, L; Lin, D; Robertson-Plouch, C; Tohen, M; Wagner, K; Wozniak, J; Xu, W, 2007) |
| " The current obesity epidemic has in fact made it relatively frequent even among children and adolescents to find some cardiovascular risk factors known in adults such as arterial hypertension, dyslipidemia, glucose metabolism disorders and increased of uric acid values." | 5.01 | Prevention of Cardiovascular Diseases in Children and Adolescents. ( Battaglino, MG; Genovesi, S; Giussani, M; Nava, E; Orlando, A; Parati, G, 2019) |
| " The link between increased fructose consumption and increases in uric acid also has been confirmed as a potential risk factor for metabolic syndrome, and insulin resistance/hyperinsulinemia may be causally related to the development of hypertension." | 4.91 | Health implications of high-fructose intake and current research. ( de Lima, WG; Dornas, WC; Pedrosa, ML; Silva, ME, 2015) |
| "Uric acid has historically been viewed as a purine metabolic waste product excreted by the kidney and gut that is relatively unimportant other than its penchant to crystallize in joints to cause the disease gout." | 4.85 | Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? ( Benner, SA; Gabriela Sanchez-Lozada, L; Johnson, RJ; Mu, W; Nakagawa, T; Oliver, WJ; Rodriguez-Iturbe, B; Roncal, C; Sautin, YY, 2009) |
| "Previous evidence suggests that higher blood uric acid (UA) levels are associated with adverse cardiovascular outcomes during pregnancy and subsequent birth outcomes." | 4.31 | Associations of early pregnancy serum uric acid levels with risk of gestational diabetes and birth outcomes: a retrospective cohort study. ( Chen, GD; Guo, XL; Li, PS; Liu, ZP; Ma, HT; Pang, TT; Shen, XY; Wan, YC; Zhou, ZX, 2023) |
| " Indirect associations were mediated through the triglyceride-glucose (TyG) index (as an indicator of insulin resistance), mean arterial pressure (MAP), uric acid (UA), and total cholesterol (TC)." | 4.12 | The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia. ( Brozek, W; Concin, H; Fritz, J; Kerschbaum, J; Lhotta, K; Nagel, G; Ulmer, H; Zitt, E, 2022) |
| " Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight." | 4.02 | Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice. ( Akari, S; Katoh, N; Mizukami, H; Murase, T; Nakamura, T; Nampei, M; Satoh, E, 2021) |
| " The animals in the treatment with parboiled rice showed higher body weight gain, feed intake, nitrogen excretion, serum triglycerides, uric acid levels and pancreas weight and lower feed conversion, faecal pH, albumin and serum HDL cholesterol, when compared with the treatment with white rice." | 3.78 | Effect of rice parboiling on performance and metabolic responses in rats. ( Boufleur, N; da Silva, LP; Denardin, CC; Emanuelli, T; Reckziegel, P, 2012) |
| " Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased." | 3.76 | Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010) |
| " To clarify the relations between serum uric acid, plasma norepinephrine, and insulin or leptin levels in subjects with weight gain-induced blood pressure elevation, we conducted the present longitudinal study." | 3.72 | Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. ( Kawaguchi, H; Masuo, K; Mikami, H; Ogihara, T; Tuck, ML, 2003) |
| " After acute exposure, the herbicide decreased motor activity and induced muscular weakness and motor incoordination; decreased weight gain; increased serum creatine kinase (CK) and alkaline phosphatase (AP) activities and serum uric acid (UA), creatinine (CR), and total proteins (TP) levels; and did not change serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities." | 3.70 | Acute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicks. ( Dagli, ML; Morgulis, MS; Oliveira, GH; Palermo-Neto, J, 1998) |
| " The low vitamin C diet decreased body weight gain, food intake, and heart malondialdehyde without changing lipid peroxidation, whereas the high vitamin C increased oxidized glutathione and glutathione peroxidase and decreased body growth." | 3.69 | Effect of vitamin C on antioxidants, lipid peroxidation, and GSH system in the normal guinea pig heart. ( Barja, G; Cadenas, S; López-Torres, M; Pérez-Campo, R; Rojas, C, 1994) |
| "Systolic blood pressure, diastolic blood pressure, serum cholesterol, serum uric acid, past history of illness, present illness, body mass index (BMI: weight/height2 (kg/m2)), indices of weight change (the intrapersonal standard deviation of BMI (ISD), the coefficient of variation of BMI (CV), the root mean square error of variation (RMSE) around the slope of BMI vs age, weight change categories (cycler, weight gainer, no changer, etc." | 3.69 | An evaluation of various indices of body weight change and their relationship with coronary risk factors. ( Horie, S; Itoh, T; Okubo, T; Takahashi, K, 1996) |
| "5% without dose-response relationship." | 3.01 | Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet. ( Burnier, M; Dingemanse, J; Flamion, B; Gueneau de Mussy, P; Guérard, N; Iglarz, M; Maillard, MP; Sidharta, PN; Wuerzner, G, 2021) |
| "The signs and symptoms of preeclampsia are usually apparent at a relatively late stage in pregnancy (late second to early third trimester)." | 2.38 | Early detection of preeclampsia. ( Dekker, GA; Sibai, BM, 1991) |
| "The anti-NAFLD effect of SMF was linked to modulation of the gut microbiota composition and in particular an increased relative abundance of Akkermansia muciniphila." | 1.62 | Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota. ( Chen, L; Han, R; Hong, Y; Li, B; Li, H; Ma, J; Qiu, H; Sheng, L; Wu, G; Zheng, N; Zhong, J, 2021) |
| "Recent investigations have proved the crucial role of nutritional antioxidants to prevent the damage caused by toxic compounds." | 1.38 | Antioxidant-rich date palm fruit extract inhibits oxidative stress and nephrotoxicity induced by dimethoate in rat. ( Achour, L; El Arem, A; Elfeki, A; Hammami, M; Louedi, M; Najjar, MF; Saafi-Ben Salah, EB; Saoudi, M; Zakhama, A, 2012) |
| "Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease." | 1.36 | Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men. ( Cai, Q; Elasy, T; Fazio, S; Li, H; Linton, M; Shu, XO; Villegas, R; Xiang, YB; Zheng, W, 2010) |
| "Hyperinsulinemia is associated with several health risks, such as cardiovascular diseases and the metabolic syndrome." | 1.33 | Insulin-related metabolic changes during treatment with valproate in patients with epilepsy. ( Isojärvi, J; Knip, M; Pakarinen, A; Pylvänen, V, 2006) |
| " In contrast, supplemental T(3) decreased IVL in euthyroid birds, regardless of the dosing interval, but had no effect on ME activity." | 1.32 | Methimazole and thyroid hormone replacement in broilers. ( McMurtry, JP; Rosebrough, RW, 2003) |
| "Body weights were measured biweekly throughout the study, and blood samples were drawn from wk 8 to 10 for determination of PUA concentration, leukocyte oxidative activity (LOA), and differential leukocyte counts." | 1.32 | Fructose and its effect on turkey plasma uric acid levels and productive performance. ( Klandorf, H; Simoyi, MF, 2003) |
| " Female turkeys, 8 weeks of age, were dually cannulated via the right jugular for intermittent (10 min every 2 hr) infusion of tGH at a low dosage (4." | 1.29 | Responses to exogenous pulsatile turkey growth hormone by growing 8-week-old female turkeys. ( Bacon, WL; Long, DW; Vasilatos-Younken, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (22.22) | 18.2507 |
| 2000's | 14 (31.11) | 29.6817 |
| 2010's | 14 (31.11) | 24.3611 |
| 2020's | 7 (15.56) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Qu, Y | 1 |
| Lv, X | 1 |
| Zhao, R | 2 |
| Yu, J | 1 |
| Hu, S | 1 |
| Kang, J | 1 |
| Zhang, Y | 1 |
| Gong, Y | 1 |
| Cui, T | 1 |
| Zhang, X | 3 |
| Yan, Y | 1 |
| Fritz, J | 1 |
| Brozek, W | 1 |
| Concin, H | 1 |
| Nagel, G | 1 |
| Kerschbaum, J | 1 |
| Lhotta, K | 1 |
| Ulmer, H | 1 |
| Zitt, E | 1 |
| Corso, LML | 1 |
| Wing, RR | 1 |
| Tate, DF | 1 |
| Espeland, MA | 1 |
| Blanchard, BE | 1 |
| McCaffery, JM | 1 |
| Pang, TT | 1 |
| Zhou, ZX | 1 |
| Li, PS | 1 |
| Ma, HT | 1 |
| Shen, XY | 1 |
| Wan, YC | 1 |
| Guo, XL | 1 |
| Liu, ZP | 1 |
| Chen, GD | 1 |
| Yang, SC | 1 |
| Huang, WC | 1 |
| Ng, XE | 1 |
| Lee, MC | 1 |
| Hsu, YJ | 1 |
| Huang, CC | 1 |
| Wu, HH | 1 |
| Yeh, CL | 1 |
| Shirakawa, H | 1 |
| Budijanto, S | 1 |
| Tung, TH | 1 |
| Tung, YT | 1 |
| Gueneau de Mussy, P | 1 |
| Sidharta, PN | 1 |
| Wuerzner, G | 1 |
| Maillard, MP | 1 |
| Guérard, N | 1 |
| Iglarz, M | 1 |
| Flamion, B | 1 |
| Dingemanse, J | 1 |
| Burnier, M | 1 |
| Han, R | 1 |
| Qiu, H | 1 |
| Zhong, J | 1 |
| Zheng, N | 1 |
| Li, B | 1 |
| Hong, Y | 1 |
| Ma, J | 1 |
| Wu, G | 1 |
| Chen, L | 1 |
| Sheng, L | 1 |
| Li, H | 2 |
| Nakamura, T | 1 |
| Nampei, M | 1 |
| Murase, T | 1 |
| Satoh, E | 1 |
| Akari, S | 1 |
| Katoh, N | 1 |
| Mizukami, H | 1 |
| Menni, C | 1 |
| Migaud, M | 1 |
| Kastenmüller, G | 1 |
| Pallister, T | 1 |
| Zierer, J | 1 |
| Peters, A | 1 |
| Mohney, RP | 1 |
| Spector, TD | 1 |
| Bagnardi, V | 1 |
| Gieger, C | 1 |
| Moore, SC | 1 |
| Valdes, AM | 1 |
| Chen, D | 1 |
| Wu, H | 1 |
| Liu, M | 1 |
| Zhang, M | 1 |
| Chen, X | 1 |
| Genovesi, S | 1 |
| Giussani, M | 1 |
| Orlando, A | 1 |
| Battaglino, MG | 1 |
| Nava, E | 1 |
| Parati, G | 1 |
| Johnson, RJ | 2 |
| Nakagawa, T | 2 |
| Sanchez-Lozada, LG | 1 |
| Shafiu, M | 1 |
| Sundaram, S | 1 |
| Le, M | 1 |
| Ishimoto, T | 1 |
| Sautin, YY | 2 |
| Lanaspa, MA | 1 |
| Xu, M | 1 |
| Ma, Y | 1 |
| Xu, L | 1 |
| Xu, Y | 1 |
| Li, Y | 1 |
| Lurbe, E | 1 |
| Garcia-Vicent, C | 1 |
| Torro, MI | 1 |
| Aguilar, F | 1 |
| Redon, J | 1 |
| Osaki, A | 1 |
| Okazaki, Y | 1 |
| Kimoto, A | 1 |
| Izu, H | 1 |
| Kato, N | 1 |
| Dornas, WC | 1 |
| de Lima, WG | 1 |
| Pedrosa, ML | 1 |
| Silva, ME | 1 |
| Oliver, WJ | 1 |
| Roncal, C | 1 |
| Mu, W | 1 |
| Gabriela Sanchez-Lozada, L | 1 |
| Rodriguez-Iturbe, B | 1 |
| Benner, SA | 1 |
| Cai, Y | 1 |
| Song, Z | 1 |
| Wang, X | 1 |
| Jiao, H | 1 |
| Lin, H | 1 |
| Iffiú-Soltész, Z | 1 |
| Wanecq, E | 1 |
| Lomba, A | 1 |
| Portillo, MP | 1 |
| Pellati, F | 1 |
| Szöko, E | 1 |
| Bour, S | 1 |
| Woodley, J | 1 |
| Milagro, FI | 1 |
| Alfredo Martinez, J | 1 |
| Valet, P | 1 |
| Carpéné, C | 1 |
| Villegas, R | 1 |
| Xiang, YB | 1 |
| Cai, Q | 1 |
| Fazio, S | 1 |
| Linton, M | 1 |
| Elasy, T | 1 |
| Zheng, W | 1 |
| Shu, XO | 1 |
| Saafi-Ben Salah, EB | 1 |
| El Arem, A | 1 |
| Louedi, M | 1 |
| Saoudi, M | 1 |
| Elfeki, A | 1 |
| Zakhama, A | 1 |
| Najjar, MF | 1 |
| Hammami, M | 1 |
| Achour, L | 1 |
| Denardin, CC | 1 |
| Boufleur, N | 1 |
| Reckziegel, P | 1 |
| Emanuelli, T | 1 |
| da Silva, LP | 1 |
| Rosebrough, RW | 1 |
| McMurtry, JP | 1 |
| Simoyi, MF | 1 |
| Klandorf, H | 1 |
| Masuo, K | 1 |
| Kawaguchi, H | 1 |
| Mikami, H | 1 |
| Ogihara, T | 1 |
| Tuck, ML | 1 |
| Rubio, LA | 1 |
| Brenes, A | 1 |
| Centeno, C | 1 |
| Xie, M | 1 |
| Hou, SS | 1 |
| Huang, W | 1 |
| Zhao, L | 1 |
| Yu, JY | 1 |
| Li, WY | 1 |
| Wu, YY | 1 |
| Koguchi, T | 1 |
| Koguchi, H | 1 |
| Nakajima, H | 1 |
| Takano, S | 1 |
| Yamamoto, Y | 1 |
| Innami, S | 1 |
| Maekawa, A | 1 |
| Tadokoro, T | 1 |
| Mandal, PK | 1 |
| Gupta, MK | 1 |
| Singh, KK | 1 |
| Pylvänen, V | 1 |
| Pakarinen, A | 1 |
| Knip, M | 1 |
| Isojärvi, J | 1 |
| Tohen, M | 1 |
| Kryzhanovskaya, L | 1 |
| Carlson, G | 1 |
| Delbello, M | 1 |
| Wozniak, J | 1 |
| Kowatch, R | 1 |
| Wagner, K | 1 |
| Findling, R | 1 |
| Lin, D | 1 |
| Robertson-Plouch, C | 1 |
| Xu, W | 1 |
| Dittmann, RW | 1 |
| Biederman, J | 1 |
| Hellwing, AL | 1 |
| Tauson, AH | 1 |
| Skrede, A | 1 |
| Yang, KH | 1 |
| Lee, JH | 1 |
| Lee, MG | 1 |
| Bacon, WL | 1 |
| Long, DW | 1 |
| Vasilatos-Younken, R | 1 |
| Rojas, C | 1 |
| Cadenas, S | 1 |
| Pérez-Campo, R | 1 |
| López-Torres, M | 1 |
| Barja, G | 1 |
| Itoh, T | 1 |
| Horie, S | 1 |
| Takahashi, K | 1 |
| Okubo, T | 1 |
| Morgulis, MS | 1 |
| Oliveira, GH | 1 |
| Dagli, ML | 1 |
| Palermo-Neto, J | 1 |
| Kikuchi, T | 1 |
| Matsuzaki, H | 1 |
| Sato, S | 1 |
| Kajita, Y | 1 |
| Chiba, H | 1 |
| Tsuchiya, H | 1 |
| Masuyama, R | 1 |
| Uehara, M | 1 |
| Suzuki, K | 1 |
| Goto, S | 1 |
| Son, JH | 1 |
| Karasawa, Y | 1 |
| Nahm, KH | 1 |
| Dekker, GA | 1 |
| Sibai, BM | 1 |
| Kaltner, H | 1 |
| Heydner, C | 1 |
| Wittmann, J | 1 |
| Earle, KE | 1 |
| Clarke, NR | 1 |
| Tartagni, M | 1 |
| Loizzi, P | 1 |
| Diaferia, A | 1 |
| Ceci, O | 1 |
| Giesecke, D | 1 |
| Gallenmüller, P | 1 |
| Tiemeyer, W | 1 |
| Gropp, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Novel Approaches for Prevention[NCT01183689] | 599 participants (Actual) | Interventional | 2010-08-31 | Completed | |||
| Genetic-specific Effects of Fructose on Liver Lipogenesis[NCT03783195] | 15 participants (Actual) | Interventional | 2019-01-25 | Completed | |||
| Association Between Enhanced Sympathetic Activity and Cardiometabolic Complications: a Cross-sectional Study on Predictive Power of 24-hour Urinary Metanephrines (SYMPACT)[NCT04495231] | 1,380 participants (Actual) | Observational | 2007-09-01 | Completed | |||
| Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder[NCT00050206] | Phase 4 | 130 participants | Interventional | 2002-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Waist circumference will be measured using a Gulik tape measure and following a standardized protocol. Two measures of waist circumference will be taken; if the difference exceeds 1.0 cm, a third measure will be taken. Changes are measured from baseline to year 2. (NCT01183689)
Timeframe: Change from baseline to 2 years
| Intervention | centimeters (Mean) |
|---|---|
| Control Group | 0.21 |
| Small Behavior Changes | -1.06 |
| Large Behavior Changes | -2.21 |
Mean changes in the Center for Epidemiologic Studies Depression (CES-C) Scale. Reference: Turvey, C. L., Wallace, R. B., & Herzog, R. (1999). A revised CES-D measure of depressive symptoms and a DSM-based measure of major depressive episodes in the elderly. Int Psychogeriatr, 11(2), 139-148. 20 item questionnaire with a possible range of scores is zero to 60, and higher scores indicating the presence of more symptomatology. (NCT01183689)
Timeframe: 2 years
| Intervention | units on a scale (Mean) |
|---|---|
| Control Group | 1.68 |
| Small Behavior Changes | 0.60 |
| Large Behavior Changes | 1.73 |
"The Eating Inventory (Stunkard, 1988) is a 51-item self-report instrument, was used to assess the subscale of dietary restraint (e.g., degree of conscious control exerted over eating behaviors; range from 0-21 with higher scores reflecting greater levels of restraint).~Reference: Stunkard, A. J. M., S. (1988). Eating Inventory Manual. New York: Psychological Corporation." (NCT01183689)
Timeframe: 2 years
| Intervention | Units on a scale (Mean) |
|---|---|
| Control Group | 0.39 |
| Small Behavior Changes | 0.59 |
| Large Behavior Changes | 1.27 |
"The Eating Inventory (TFEQ(Stunkard, 1988), a 51-item self-report instrument, was used to assess the subscale of disinhibition (e.g., susceptibility to loss of control over eating; range 0-16, with higher scores reflecting greater levels of disinhibition).~REF: Stunkard, A. J. M., S. (1988). Eating Inventory Manual. New York: Psychological Corporation." (NCT01183689)
Timeframe: Changes at 2 years
| Intervention | Units on a scale (Mean) |
|---|---|
| Control Group | 0.07 |
| Small Behavior Changes | -0.78 |
| Large Behavior Changes | -0.03 |
"Flexible control is characterized by a balanced approach to eating (e.g., taking smaller portions to control weight, engaging in healthy compensation) and is associated with better weight management outcomes (Westenhoefer, Stunkard, & Pudel, 1999). Scores range from 0 to 12 with higher scores reflecting greater levels of flexible control.~REF: Westenhoefer, J., Stunkard, A. J., & Pudel, V. (1999). Validation of the flexible and rigid control dimensions of dietary restraint. Int J Eat Disord, 26(1), 53-64." (NCT01183689)
Timeframe: Changes from baseline to 2 years
| Intervention | units on a scale (Mean) |
|---|---|
| Control Group | 0.39 |
| Small Behavior Changes | 0.59 |
| Large Behavior Changes | 1.27 |
"The General Health Index, a one-item question from the CDC's Health-Related Quality of Life measure (Measuring Healthy Days, 2000) required participants to report whether in general their health is excellent (1), very good (2), good (3), fair (4), or poor (5). Lower scores denotes better outcomes.~Ref: Measuring Healthy Days. (2000). Atlanta, Georgia: Centers for Disease Control and Prevention" (NCT01183689)
Timeframe: Changes from baseline to 2 years
| Intervention | 2 year changes in units on a scale (Mean) |
|---|---|
| Control Group | 0.04 |
| Small Behavior Changes | -0.04 |
| Large Behavior Changes | -0.11 |
We calculated homeostatic model assessment insulin resistance (HOMA-IR): fasting glucose in (mg/dl) * fasting insulin in (uU/mL). (NCT01183689)
Timeframe: Change from baseline to 2 years
| Intervention | HOMA-IR (Mean) |
|---|---|
| Control Group | -0.03 |
| Small Behavior Changes | -0.15 |
| Large Behavior Changes | -0.33 |
Mean change in fasting glucose from baseline to 2 years in mg/dl for all participants with year 2 measures (NCT01183689)
Timeframe: 2 years
| Intervention | Mean change from baseline in mg/dl (Mean) |
|---|---|
| Control Group | 1.48 |
| Small Behavior Changes | 0.40 |
| Large Behavior Changes | -0.18 |
Mean change in fasting insulin (uU/ml) from baseline to 2 years (NCT01183689)
Timeframe: 2 years
| Intervention | Mean changes at 2 years in uU/ml (Mean) |
|---|---|
| Control Group | -0.27 |
| Small Behavior Changes | -0.73 |
| Large Behavior Changes | -1.48 |
Change from baseline to 2 years in diastolic blood pressure (NCT01183689)
Timeframe: 2 years
| Intervention | mmHg (Mean) |
|---|---|
| Control Group | -0.41 |
| Small Behavior Changes | -2.14 |
| Large Behavior Changes | -1.33 |
Mean changes from baseline to 2 years in total cholesterol among participants with Year 2 measurements (mg/dl) (NCT01183689)
Timeframe: 2 years
| Intervention | mg/dl (Mean) |
|---|---|
| Control Group | -0.56 |
| Small Behavior Changes | 0.74 |
| Large Behavior Changes | 1.33 |
Mean changes in HDL-C from baseline to year 2 in (mg/dl) for compared among the 3 arms using analysis of variance (NCT01183689)
Timeframe: 2 years
| Intervention | Mean Change from Baseline in mg/dl (Mean) |
|---|---|
| Control Group | -0.09 |
| Small Behavior Changes | 1.43 |
| Large Behavior Changes | 2.12 |
Mean changes between baseline and 2 years in low density lipoprotein cholesterol: LDL-c (mg/dl) (NCT01183689)
Timeframe: 2 years
| Intervention | Mean change in LDL-C in mg/dl (Mean) |
|---|---|
| Control Group | -0.01 |
| Small Behavior Changes | 0.16 |
| Large Behavior Changes | 1.43 |
Compare changes in systolic blood pressure across the three intervention groups (NCT01183689)
Timeframe: Measured at 2 Years
| Intervention | mmHg (Mean) |
|---|---|
| Control Group | 1.73 |
| Small Behavior Changes | -3.72 |
| Large Behavior Changes | -2.66 |
Mean differences in weight changes among intervention groups at 24 months post-randomization (NCT01183689)
Timeframe: 2 years
| Intervention | kilograms (Mean) |
|---|---|
| Control Group | 0.54 |
| Self-regulation With Small Behavior Changes | -0.77 |
| Self-regulation With Large Behavior Changes | -1.50 |
Percentage of those participants whose body mass index at baseline was less than 30 kg/m2 who subsequently transitioned to a body mass index of 30 kg/m2 or more (i.e. met criteria for obesity) sometime during 3 years of follow-up (i.e. at least one visit). Percentages will be compared among the three arms of the trial and summarized with odds ratios Participants were assigned values of 0 or 1 at each exam depending on their obesity level. Inference is based on generalized estimating equations. (NCT01183689)
Timeframe: 3 years
| Intervention | percentage of participants (Mean) |
|---|---|
| Control Group | 16.9 |
| Self-regulation With Small Behavior Changes | 7.9 |
| Self-regulation With Large Behavior Changes | 8.6 |
"Rigid control is characterized by an all-or-nothing inflexibility around dietary rules (e.g., strict calorie counting, with guilt following if calorie-dense foods are consumed) that is associated with poor weight outcomes and more binge eating (Westenhoefer, Stunkard, & Pudel, 1999). Scores range from 0 to 16 with higher scores reflecting greater rigid control.~REF: Stunkard, A. J. M., S. (1988). Eating Inventory Manual. New York: Psychological Corporation." (NCT01183689)
Timeframe: Changes from baseline to 2 years
| Intervention | 2 year changes in units on a scale (Mean) |
|---|---|
| Control Group | 0.35 |
| Small Behavior Changes | 0.22 |
| Large Behavior Changes | 1.75 |
Number of days per week the participant reports weighing themselves. This is divided into two groups: 1) more than once per week and 2) no more than once per week (NCT01183689)
Timeframe: 2 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 30 |
| Small Behavior Changes | 44 |
| Large Behavior Changes | 56 |
"Dietary intake was assessed using the 2005 Block Food Frequency Questionnaire (Block FFQ) at baseline and 2 years. This validated, quantitative 110-food item questionnaire is designed to assess relative intake of energy.~REF: Block G, Woods M, Potosky A, Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol 1990; 43:1327-1335." (NCT01183689)
Timeframe: Changes from baseline to 2 years in kilocalories
| Intervention | kilocalories (Mean) |
|---|---|
| Control Group | -134 |
| Small Behavior Changes | -186 |
| Large Behavior Changes | -185 |
Mean weight change from baseline across an average planned follow-up of three years. These mean changes will be compared among the three arms of the trial. (NCT01183689)
Timeframe: 3 years
| Intervention | kilograms (Mean) |
|---|---|
| Control Group | 0.26 |
| Self-regulation With Small Behavior Changes | -0.56 |
| Self-regulation With Large Behavior Changes | -2.37 |
Average over time (average follow-up of 3 years) of the percent of participants within each arm of the trial who gain 1 pound or more at each visit. These percentages will be compared among the three arms generalized estimating equations. Note that weight changes in units of pounds were used to define this outcome so that it may be more clear to participants. Elsewhere in the protocol, weight is reported in kilograms. Percentages at each visit are the percent who gained 1 pound or more from baseline among all who were weighed at that visit. Participants were assigned values of 0 or 1 at each visit depending on their weight gain status. (NCT01183689)
Timeframe: 3 years
| Intervention | percentage gaining 1 pound or more among (Mean) |
|---|---|
| Control Group | 40.8 |
| Self-regulation With Small Behavior Changes | 32.5 |
| Self-regulation With Large Behavior Changes | 23.6 |
5 reviews available for uric acid and Weight Gain
| Article | Year |
|---|---|
Prevention of Cardiovascular Diseases in Children and Adolescents.
Topics: Adolescent; Age of Onset; Arterial Pressure; Biomarkers; Blood Glucose; Cardiovascular Diseases; Chi | 2019 |
Sugar, uric acid, and the etiology of diabetes and obesity.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Sucrose; Disease Models, Animal | 2013 |
Health implications of high-fructose intake and current research.
Topics: Animals; Diet; Dietary Sucrose; Fructose; Humans; Hypertension; Hypertriglyceridemia; Insulin; Insul | 2015 |
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Pressure; Evolution, Molecular; Fasting; Fructose; Gout; | 2009 |
Early detection of preeclampsia.
Topics: Biomarkers; Blood Coagulation Factors; Blood Pressure; Calcium; Epoprostenol; Female; Humans; Platel | 1991 |
3 trials available for uric acid and Weight Gain
| Article | Year |
|---|---|
Uric acid as a predictor of weight gain and cardiometabolic health in the Study of Novel Approaches to Weight Gain Prevention (SNAP) study.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Obesity; Risk Factors; Uric Acid; | 2022 |
Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet.
Topics: Administration, Oral; Adult; Aldosterone; Body Water; Cross-Over Studies; Double-Blind Method; Endot | 2021 |
Olanzapine versus placebo in the treatment of adolescents with bipolar mania.
Topics: Adolescent; Age Factors; Alanine Transaminase; Antipsychotic Agents; Aspartate Aminotransferases; Be | 2007 |
37 other studies available for uric acid and Weight Gain
| Article | Year |
|---|---|
Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats.
Topics: Animals; Aorta; Atherosclerosis; Benzodioxoles; Cholesterol, Dietary; Diet, High-Fat; Dietary Carboh | 2021 |
The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia.
Topics: Adult; Biomarkers; Blood Glucose; Body Mass Index; Glucose; Humans; Hypertension; Hyperuricemia; Ins | 2022 |
Associations of early pregnancy serum uric acid levels with risk of gestational diabetes and birth outcomes: a retrospective cohort study.
Topics: Diabetes, Gestational; Female; Fetal Growth Retardation; Fetal Macrosomia; Humans; Hyperuricemia; In | 2023 |
Rice Bran Reduces Weight Gain and Modulates Lipid Metabolism in Rats with High-Energy-Diet-Induced Obesity.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Dietary Supplements; Lipid Metabolism; Lipids; Liver; Male; | 2019 |
Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota.
Topics: Animals; Diet, High-Fat; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Inflammation; Insulin; | 2021 |
Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fatty Acids, Nonesterified | 2021 |
Metabolomic Profiling of Long-Term Weight Change: Role of Oxidative Stress and Urate Levels in Weight Gain.
Topics: Adult; Aged; Aged, 80 and over; Body Mass Index; Cohort Studies; Female; Humans; Male; Metabolomics; | 2017 |
Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics.
Topics: Allopurinol; Animals; Biomarkers; Drugs, Chinese Herbal; Fermentation; Hyperuricemia; Male; Metabolo | 2017 |
Weight gain increases plasma levels of uric acid in adults in China.
Topics: Aged; Body Mass Index; China; Female; Humans; Male; Middle Aged; Obesity; Uric Acid; Weight Gain | 2019 |
Developmental effects of dietary nucleotides in second-generation weaned rats.
Topics: Alanine Transaminase; Animal Nutritional Physiological Phenomena; Animals; Aspartate Aminotransferas | 2013 |
Associations of birth weight and postnatal weight gain with cardiometabolic risk parameters at 5 years of age.
Topics: Adult; Birth Weight; Blood Pressure; Body Mass Index; Child, Preschool; Cholesterol, LDL; Female; Fo | 2014 |
Beneficial effect of a low dose of ethanol on liver function and serum urate in rats fed a high-fat diet.
Topics: Adipose Tissue; Alanine Transaminase; Ammonia; Animals; Blood Glucose; Diet, High-Fat; Dose-Response | 2014 |
Increased de novo lipogenesis in liver contributes to the augmented fat deposition in dexamethasone exposed broiler chickens (Gallus gallus domesticus).
Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Chickens; Dexamethasone; Fatty Acid Synthases; Gene | 2009 |
Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice.
Topics: Adipocytes; Administration, Oral; Animals; Aorta; Benzylamines; Blood Glucose; Cholesterol; Hydrogen | 2010 |
Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men.
Topics: Adult; Aged; Alcohol Drinking; Asian People; Biomarkers; Body Mass Index; China; Cohort Studies; Cro | 2010 |
Antioxidant-rich date palm fruit extract inhibits oxidative stress and nephrotoxicity induced by dimethoate in rat.
Topics: Animals; Antioxidants; Arecaceae; Ascorbic Acid; Creatinine; Dimethoate; Fruit; Kidney; Kidney Corte | 2012 |
Effect of rice parboiling on performance and metabolic responses in rats.
Topics: Animal Feed; Animals; Blood Glucose; Cholesterol, HDL; Cooking; Diet; Gastrointestinal Tract; Hydrog | 2012 |
Methimazole and thyroid hormone replacement in broilers.
Topics: Animals; Aspartate Aminotransferases; Chickens; Dietary Proteins; Hypothyroidism; Insulin-Like Growt | 2003 |
Fructose and its effect on turkey plasma uric acid levels and productive performance.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Diet; Fructose; Leukocyte Count; L | 2003 |
Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation.
Topics: Adult; Blood Pressure; Demography; Humans; Insulin; Leptin; Longitudinal Studies; Male; Norepinephri | 2003 |
Effects of feeding growing broiler chickens with practical diets containing sweet lupin (Lupinus angustifolius) seed meal.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Chickens; Dietary Pro | 2003 |
Interrelationship between methionine and cystine of early Peking ducklings.
Topics: Animal Feed; Animals; Chromatography, High Pressure Liquid; Colorimetry; Cystine; Diet; Dietary Supp | 2004 |
Dietary fiber suppresses elevation of uric acid and urea nitrogen concentrations in serum of rats with renal dysfunction induced by dietary adenine.
Topics: Adenine; Animals; Blood Urea Nitrogen; Cellulose; Chitin; Chitosan; Creatinine; Diet; Dietary Fiber; | 2004 |
Pathology of benzalkonium chloride toxicity and its effect on body weight gain in broiler birds.
Topics: Alanine Transaminase; Animals; Benzalkonium Compounds; Body Weight; Chickens; Poultry Diseases; Urea | 2004 |
Insulin-related metabolic changes during treatment with valproate in patients with epilepsy.
Topics: Adult; Anticonvulsants; Body Mass Index; Epilepsy; Female; Humans; Hyperinsulinism; Insulin; Lipopro | 2006 |
Blood parameters in growing pigs fed increasing levels of bacterial protein meal.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Bacterial Protei | 2007 |
Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU.
Topics: Animals; Area Under Curve; Benz(a)Anthracenes; Chromatography, High Pressure Liquid; Cytochrome P-45 | 2008 |
Responses to exogenous pulsatile turkey growth hormone by growing 8-week-old female turkeys.
Topics: Animal Feed; Animals; Blood Glucose; Body Composition; Body Weight; Fatty Acids; Female; Growth Horm | 1995 |
Effect of vitamin C on antioxidants, lipid peroxidation, and GSH system in the normal guinea pig heart.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Diet; Eating; Glutathione; Glutathione Peroxidase; G | 1994 |
An evaluation of various indices of body weight change and their relationship with coronary risk factors.
Topics: Adult; Blood Pressure; Body Mass Index; Cholesterol; Coronary Disease; Humans; Hyperlipidemias; Hype | 1996 |
Acute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicks.
Topics: 2,4-Dichlorophenoxyacetic Acid; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; An | 1998 |
Diminished kidney function and nephrocalcinosis in rats fed a magnesium-deficient diet.
Topics: Acetylglucosaminidase; Animal Feed; Animals; Calcium; Creatinine; Kidney; Magnesium Deficiency; Male | 1998 |
Effect of caecectomy on growth, moisture in excreta, gastrointestinal passage time and uric acid excretion in growing chicks.
Topics: Animals; Body Weight; Cecum; Chickens; Chromium; Eating; Feces; Gastrointestinal Transit; Male; Nitr | 2000 |
The influence of thiourea on the development of the cultured quail embryo.
Topics: Animals; Coturnix; DNA; Thiourea; Uric Acid; Weight Gain | 1991 |
The nutrition of the budgerigar (Melopsittacus undulatus).
Topics: Animal Nutritional Physiological Phenomena; Animals; Diet; Dietary Carbohydrates; Dietary Proteins; | 1991 |
Relationship between some maternal haemato-clinical parameters and low neonatal weight. Preliminary study.
Topics: Birth Weight; Blood Pressure; Body Weight; Female; Fetal Growth Retardation; Hematocrit; Hemoglobins | 1990 |
[Effect of purine-rich nutrients on weight gain, catabolites in blood plasma and the uric acid transport of erythrocytes--a model study in dogs].
Topics: Allantoin; Animals; Biological Transport, Active; Dogs; Erythrocytes; Female; Purines; Uracil; Uric | 1990 |