Page last updated: 2024-10-20

uric acid and Vascular Calcification

uric acid has been researched along with Vascular Calcification in 15 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Vascular Calcification: Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.

Research Excerpts

ExcerptRelevanceReference
"These data suggest that factors other than uric acid may play a more important role in the regulation of CKD- MBD including vascular calcification and vitamin D metabolism in patients with CKD."9.27Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial. ( Andrews, ES; Chonchol, M; Jalal, D; Kendrick, J; Nowak, KL; Pasch, A; Perrenoud, L; You, Z, 2018)
"Uric acid (UA) has been associated with the presence and severity of coronary artery disease."7.88The association between uric acid levels and different clinical manifestations of coronary artery disease. ( Antonsen, S; Diederichsen, ACP; Gerke, O; Lambrechtsen, J; Larsen, TR; Mickley, H; Saaby, L; Sand, NP; Steffensen, FH, 2018)
"Although many studies have examined the relationship between uric acid (UA) and coronary artery disease (CAD), whether UA is an independent risk factor contributing to progression of CAD is still controversial."7.80A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China. ( Chen, L; Geng, S; Li, H; Liu, T; Qi, G; Sun, Y; Wu, C; Xu, K; Yu, X; Zhi, Y, 2014)
"These data suggest that factors other than uric acid may play a more important role in the regulation of CKD- MBD including vascular calcification and vitamin D metabolism in patients with CKD."5.27Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial. ( Andrews, ES; Chonchol, M; Jalal, D; Kendrick, J; Nowak, KL; Pasch, A; Perrenoud, L; You, Z, 2018)
"Hyperuricemia coincides with coronary artery calcification (CAC) development, but the role of serum uric acid (SUA) as a risk factor for CAC remains unclear."5.01The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis. ( Bainey, KR; Banh, HL; Hou, X; Li, W; Liang, L; Qi, Z; Tymchak, W; Zhang, Y, 2019)
"Uric acid (UA) has been associated with the presence and severity of coronary artery disease."3.88The association between uric acid levels and different clinical manifestations of coronary artery disease. ( Antonsen, S; Diederichsen, ACP; Gerke, O; Lambrechtsen, J; Larsen, TR; Mickley, H; Saaby, L; Sand, NP; Steffensen, FH, 2018)
"In this cross-sectional study, consecutive inpatients with a non-ST elevation acute coronary event and asymptomatic hyperuricemia (serum uric acid concentration of ≥7."3.83Silent Monosodium Urate Crystal Deposits Are Associated With Severe Coronary Calcification in Asymptomatic Hyperuricemia: An Exploratory Study. ( Andrés, M; Pascual, E; Quintanilla, MA; Ruiz-Nodar, JM; Sánchez-Payá, J; Sivera, F; Vela, P, 2016)
"Although many studies have examined the relationship between uric acid (UA) and coronary artery disease (CAD), whether UA is an independent risk factor contributing to progression of CAD is still controversial."3.80A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China. ( Chen, L; Geng, S; Li, H; Liu, T; Qi, G; Sun, Y; Wu, C; Xu, K; Yu, X; Zhi, Y, 2014)
"Uric acid content was associated directly with age and inversely with eGFR, was higher among males, patients with diabetes and high blood pressure."1.51Stone composition and vascular calcifications in patients with nephrolithiasis. ( Bargagli, M; Bassi, PF; Ferraro, PM; Gambaro, G; Gervasoni, J; Marano, R; Primiano, A; Rovere, G, 2019)
"Vascular calcifications are associated with nephrolithiasis."1.46Vascular Disease and Kidney Stones: Abdominal Aortic Calcifications Are Associated with Low Urine pH and Hypocitraturia. ( Calle, J; Monga, M; Patel, ND; Remer, EM; Ward, RD, 2017)
"Uric acid did not seem to be an independent risk factor for coronary artery calcium, although the prevalence and extent of coronary artery calcium increased along with the increasing trend of uric acid."1.39[Relation between uric acid and coronary artery calcification:a community-based cross-sectional survey among Beijing natural population]. ( Cao, HL; Chen, XB; Chen, Y; Gao, Y; Gu, DF; Hou, ZH; Jiang, SL; Li, Y; Lu, JG; LV, B; Tang, X; Yu, FF; Zhao, LC, 2013)
"Atherosclerotic plaque formation and vascular calcinosis were modeled in a subchronic experiment."1.38Biochemical indicators of atherogenic and protective activity of xydiphone in experimental animals. ( Dreval, AA; Ilyushina, IA; Murashov, AN; Pimenov, MS; Sukhorukov, VS; Yur'eva, EA, 2012)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (86.67)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Chen, S1
Li, N1
Gao, Y2
Jiang, H1
Shen, Y1
Liang, L1
Hou, X1
Bainey, KR1
Zhang, Y1
Tymchak, W1
Qi, Z1
Li, W1
Banh, HL1
Yan, W1
Sun, G1
Luo, A1
Lin, S1
Wang, J1
Zhang, Q1
Jiang, J1
Zhang, M1
Wang, F1
Tan, W1
Kim, H1
Kim, SH1
Choi, AR1
Kim, S1
Choi, HY1
Kim, HJ1
Park, HC1
Patel, ND1
Ward, RD1
Calle, J1
Remer, EM1
Monga, M1
Larsen, TR1
Gerke, O1
Diederichsen, ACP1
Lambrechtsen, J1
Steffensen, FH1
Sand, NP1
Saaby, L1
Antonsen, S1
Mickley, H1
Andrews, ES1
Perrenoud, L1
Nowak, KL1
You, Z1
Pasch, A1
Chonchol, M1
Kendrick, J1
Jalal, D1
Kiss, LZ1
Bagyura, Z1
Csobay-Novák, C1
Lux, Á1
Polgár, L1
Jermendy, Á1
Soós, P1
Szelid, Z1
Maurovich-Horvat, P1
Becker, D1
Merkely, B1
Harada, PH1
Benseñor, IM1
Bittencourt, MS1
Nasir, K2
Blaha, MJ1
Jones, SR1
Toth, PP1
Lotufo, PA1
Ferraro, PM1
Marano, R1
Primiano, A1
Gervasoni, J1
Bargagli, M1
Rovere, G1
Bassi, PF1
Gambaro, G1
Cao, HL1
LV, B1
Chen, XB1
Lu, JG1
Hou, ZH1
Tang, X1
Yu, FF1
Chen, Y1
Jiang, SL1
Zhao, LC1
Li, Y1
Gu, DF1
Sun, Y1
Yu, X1
Zhi, Y1
Geng, S1
Li, H1
Liu, T1
Xu, K1
Chen, L1
Wu, C1
Qi, G1
Malik, R1
Aneni, EC1
Shahrayar, S1
Freitas, WM1
Ali, SS1
Veledar, E1
Latif, MA1
Aziz, M1
Ahmed, R1
Khan, SA1
Joseph, J1
Feiz, H1
Sposito, A1
Andrés, M1
Quintanilla, MA1
Sivera, F1
Sánchez-Payá, J1
Pascual, E1
Vela, P1
Ruiz-Nodar, JM1
Yur'eva, EA1
Sukhorukov, VS1
Murashov, AN1
Pimenov, MS1
Ilyushina, IA1
Dreval, AA1

Reviews

1 review available for uric acid and Vascular Calcification

ArticleYear
The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis.
    Clinical cardiology, 2019, Volume: 42, Issue:11

    Topics: Biomarkers; Coronary Artery Disease; Coronary Vessels; Disease Progression; Global Health; Humans; H

2019

Trials

1 trial available for uric acid and Vascular Calcification

ArticleYear
Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Adolescent; Adult; Aged; Allopurinol; Carotid Intima-Media Thickness; Chronic Kidney Disease-Mineral

2018

Other Studies

13 other studies available for uric acid and Vascular Calcification

ArticleYear
Prevalence and risk factors for vascular calcification based on the ankle-brachial index in the general population: a cross-sectional study.
    BMC cardiovascular disorders, 2022, 05-18, Volume: 22, Issue:1

    Topics: Ankle Brachial Index; Blood Pressure; Body Mass Index; Cholesterol, LDL; Cross-Sectional Studies; Fe

2022
Serum uric acid is independently associated with aortic arch calcification in a cross-sectional study of middle-aged and elderly women.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2020, 06-09, Volume: 30, Issue:6

    Topics: Age Factors; Aged; Aorta, Thoracic; Aortic Diseases; Biomarkers; China; Cross-Sectional Studies; Fem

2020
Asymptomatic hyperuricemia is independently associated with coronary artery calcification in the absence of overt coronary artery disease: A single-center cross-sectional study.
    Medicine, 2017, Volume: 96, Issue:14

    Topics: Adult; Aged; Asymptomatic Diseases; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans

2017
Vascular Disease and Kidney Stones: Abdominal Aortic Calcifications Are Associated with Low Urine pH and Hypocitraturia.
    Journal of endourology, 2017, Volume: 31, Issue:9

    Topics: Adult; Aged; Aorta, Abdominal; Aortic Diseases; Citric Acid; Female; Humans; Hydrogen-Ion Concentrat

2017
The association between uric acid levels and different clinical manifestations of coronary artery disease.
    Coronary artery disease, 2018, Volume: 29, Issue:3

    Topics: Adult; Aged; Coronary Artery Disease; Coronary Vessels; Correlation of Data; Female; Humans; Male; M

2018
Serum Uric Acid Is Independently Associated with Coronary Calcification in an Asymptomatic Population.
    Journal of cardiovascular translational research, 2019, Volume: 12, Issue:3

    Topics: Aged; Asymptomatic Diseases; Biomarkers; Computed Tomography Angiography; Coronary Angiography; Coro

2019
Composite acute phase glycoproteins with coronary artery calcification depends on metabolic syndrome presence - The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
    Journal of cardiology, 2019, Volume: 73, Issue:5

    Topics: Acute-Phase Proteins; Adult; Biomarkers; Brazil; C-Reactive Protein; Coronary Artery Disease; Corona

2019
Stone composition and vascular calcifications in patients with nephrolithiasis.
    Journal of nephrology, 2019, Volume: 32, Issue:4

    Topics: Adult; Age Factors; Aged; Aorta, Abdominal; Calcium Phosphates; Cross-Sectional Studies; Diabetes Co

2019
[Relation between uric acid and coronary artery calcification:a community-based cross-sectional survey among Beijing natural population].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2013, Volume: 34, Issue:6

    Topics: Adult; Aged; China; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Male; Middle A

2013
A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China.
    BMC cardiovascular disorders, 2014, Aug-16, Volume: 14

    Topics: Aged; Biomarkers; Chi-Square Distribution; China; Coronary Angiography; Coronary Artery Disease; Cor

2014
Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging.
    Aging clinical and experimental research, 2016, Volume: 28, Issue:2

    Topics: Aged, 80 and over; Biomarkers; Brazil; C-Reactive Protein; Coronary Artery Disease; Coronary Vessels

2016
Silent Monosodium Urate Crystal Deposits Are Associated With Severe Coronary Calcification in Asymptomatic Hyperuricemia: An Exploratory Study.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:6

    Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Coronary Artery Disease; Cross-Sectional Studies; Cr

2016
Biochemical indicators of atherogenic and protective activity of xydiphone in experimental animals.
    Bulletin of experimental biology and medicine, 2012, Volume: 153, Issue:4

    Topics: Alkaline Phosphatase; Animals; Atherosclerosis; Biomarkers; Cholesterol, LDL; Creatine Kinase; Creat

2012