Page last updated: 2024-10-20

uric acid and Thrombosis

uric acid has been researched along with Thrombosis in 32 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.

Research Excerpts

ExcerptRelevanceReference
"Elderly, hospitalized coronary artery disease patients on regular aspirin treatment were enrolled from January 2014 to September 2016."7.85Predictors of high on-aspirin platelet reactivity in elderly patients with coronary artery disease. ( Chen, XH; Feng, XR; Fu, SW; He, XQ; Liang, WY; Liu, ML; Liu, WW; McCaffrey, TA; Zhang, JW, 2017)
"A larger LAAPD and an elevated serum uric acid level were found to be independent predictors of LA thrombosis in patients with MS in SR."7.81Usefulness of the uric acid and CHA₂DS₂-VASc score in prediction of left atrial thrombosis in patients with mitral stenosis and sinus rhythm. ( Akın, F; Akturk, F; Aslan, S; Bırand, A; Celık, O; Ozturk, D; Ozyılmaz, SO; Yıldırım, A, 2015)
"To examine the association between renal function, serum uric acid and markers of both pro-inflammatory and prothrombotic state in patients with diabetes mellitus (DM), metabolic syndrome and coronary artery disease."7.77Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease. ( Buraczyńska, MJ; Kondracki, B; Rychta, E; Waciński, P; Wysokiński, A; Zapolski, T, 2011)
"Primary (PMF) and secondary myelofibrosis (SMF) are myeloproliferative neoplasms characterized by high cellular turnover and substantial risk of thrombosis and death."5.72Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis. ( Galusic, D; Holik, H; Krecak, I; Kusec, R; Lucijanic, M; Moric Peric, M; Pejsa, V; Perisa, V; Sedinic, M; Stoos-Veic, T; Zekanovic, I, 2022)
"SUA levels in patients with LA thrombus were significantly greater (413."5.40Serum uric acid and risk of left atrial thrombus in patients with nonvalvular atrial fibrillation. ( Bai, R; Dong, JZ; Du, X; Jiang, CX; Kang, JP; Long, DY; Ma, CS; Ning, M; Salim, M; Sang, CH; Tang, RB; Wu, JH; Yan, XL; Yao, Y; Yu, RH, 2014)
"The role of uric acid (UA) in the process of atherothrombosis is controversial."5.12Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. ( Bandinelli, S; Cherubini, A; Ferrucci, L; Lauretani, F; Maggio, M; Miller, E; Najjar, SS; Ruggiero, C; Senin, U, 2007)
" There were statistically significant differences between the two groups in terms of age, body mass index (BMI), N-terminal prohormone of brain natriuretic peptide NT-probNP, fibrinogen, CHA2DS2-VASC [congestive Heart Failure, Hypertension, Age (75 or older), diabetes mellitus, stroke, vascular disease, age (65-74), sex category] score, paroxysmal atrial fibrillation, renal insufficiency, D-dimer, heart failure, and serum uric acid (p<0."4.31Predictive value of echocardiography combined with CT angiography for left atrial appendage thrombosis in patients with non-valvular atrial fibrillation. ( Xing, LM; Zhong, J, 2023)
"Elderly, hospitalized coronary artery disease patients on regular aspirin treatment were enrolled from January 2014 to September 2016."3.85Predictors of high on-aspirin platelet reactivity in elderly patients with coronary artery disease. ( Chen, XH; Feng, XR; Fu, SW; He, XQ; Liang, WY; Liu, ML; Liu, WW; McCaffrey, TA; Zhang, JW, 2017)
"A larger LAAPD and an elevated serum uric acid level were found to be independent predictors of LA thrombosis in patients with MS in SR."3.81Usefulness of the uric acid and CHA₂DS₂-VASc score in prediction of left atrial thrombosis in patients with mitral stenosis and sinus rhythm. ( Akın, F; Akturk, F; Aslan, S; Bırand, A; Celık, O; Ozturk, D; Ozyılmaz, SO; Yıldırım, A, 2015)
"To examine the association between renal function, serum uric acid and markers of both pro-inflammatory and prothrombotic state in patients with diabetes mellitus (DM), metabolic syndrome and coronary artery disease."3.77Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease. ( Buraczyńska, MJ; Kondracki, B; Rychta, E; Waciński, P; Wysokiński, A; Zapolski, T, 2011)
"The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial."3.73Uric acid and inflammatory markers. ( Bandinelli, S; Ble, A; Bos, AJ; Cherubini, A; Dixit, VD; Ferrucci, L; Lauretani, F; Maggio, M; Ruggiero, C; Senin, U, 2006)
"Arterial platelet thrombosis induced by topical superfusion with adenosine diphosphate (ADP) is enhanced by tranylcypromine, an inhibitor of prostacyclin-synthetase."3.67The effect of free radical scavengers on "in vivo" induced arterial thrombosis in relation to the arachidonate cascade. ( Andries, R; Bourgain, RH; Braquet, P; Deby, C, 1985)
"Accumulating evidence suggests that hemiparesis exerts a protective effect against gout via the down-regulation of mechanical and neural modulators of inflammation in neurologically impaired extremities."2.46Polyarticular gout attacks following cerebrovascular accidents: is hemiparesis in fact protective? 2 cases and a review of the literature. ( Furer, V; Hsiao, SJ; Samuels, J; Vaynrub, M, 2010)
"Primary (PMF) and secondary myelofibrosis (SMF) are myeloproliferative neoplasms characterized by high cellular turnover and substantial risk of thrombosis and death."1.72Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis. ( Galusic, D; Holik, H; Krecak, I; Kusec, R; Lucijanic, M; Moric Peric, M; Pejsa, V; Perisa, V; Sedinic, M; Stoos-Veic, T; Zekanovic, I, 2022)
"SUA levels in patients with LA thrombus were significantly greater (413."1.40Serum uric acid and risk of left atrial thrombus in patients with nonvalvular atrial fibrillation. ( Bai, R; Dong, JZ; Du, X; Jiang, CX; Kang, JP; Long, DY; Ma, CS; Ning, M; Salim, M; Sang, CH; Tang, RB; Wu, JH; Yan, XL; Yao, Y; Yu, RH, 2014)
" These results were obtained with an average dosage of 19 +/- 4."1.29[Long-term hematological management of cyanotic congenital heart diseases]. ( Cornu, P, 1994)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199016 (50.00)18.7374
1990's2 (6.25)18.2507
2000's3 (9.38)29.6817
2010's7 (21.88)24.3611
2020's4 (12.50)2.80

Authors

AuthorsStudies
Tang, L1
Xia, Y1
Fang, L1
Zhong, J1
Xing, LM1
Mineiro, MF1
Patricio, ES1
Peixoto, ÁS1
Araujo, TLS1
da Silva, RP1
Moretti, AIS1
Lima, FS1
Laurindo, FRM1
Meotti, FC1
Lucijanic, M1
Krecak, I1
Galusic, D1
Sedinic, M1
Holik, H1
Perisa, V1
Moric Peric, M1
Zekanovic, I1
Stoos-Veic, T1
Pejsa, V1
Kusec, R1
Zhang, JW1
Liu, WW1
McCaffrey, TA1
He, XQ1
Liang, WY1
Chen, XH1
Feng, XR1
Fu, SW1
Liu, ML1
Atıl, A1
Deniz, A1
Ozturk, D1
Celık, O1
Akın, F1
Akturk, F1
Aslan, S1
Ozyılmaz, SO1
Bırand, A1
Yıldırım, A1
Nattel, S1
Tang, RB1
Dong, JZ1
Yan, XL1
Du, X1
Kang, JP1
Wu, JH1
Yu, RH1
Long, DY1
Ning, M1
Sang, CH1
Jiang, CX1
Salim, M1
Bai, R1
Yao, Y1
Ma, CS1
Hsiao, SJ1
Vaynrub, M1
Furer, V1
Samuels, J1
Zapolski, T1
Waciński, P1
Kondracki, B1
Rychta, E1
Buraczyńska, MJ1
Wysokiński, A1
Saito, A2
Ruggiero, C2
Cherubini, A2
Ble, A1
Bos, AJ1
Maggio, M2
Dixit, VD1
Lauretani, F2
Bandinelli, S2
Senin, U2
Ferrucci, L2
Miller, E1
Najjar, SS1
Bourde, CH1
Newland, H3
Nordöy, A1
Bourgain, RH2
Deby, C2
Deby-Dupont, G1
Andries, R2
Cornu, P1
Ceriello, A1
Bortolotti, N1
Pirisi, M1
Crescentini, A1
Tonutti, L1
Motz, E1
Russo, A1
Giacomello, R1
Stel, G1
Taboga, C1
Klein, S1
Marré, E1
Koza, KD1
Heidelmann, G2
Algan, B1
Leyder, C1
Marchal, H1
Geoffroy, D1
Marquis, A1
Braquet, P1
Marx, H1
Soroka, RJ1
Rose, FL1
Esmond, WG1
Ota, K1
Shimoji, T1
Maeda, K1
Kobayashi, K1
Fessel, WJ1
Thiele, P1
Gärtner, A1
Schneider, V1
Tellkamp, F1
Balík, J1
Laufbergerová, J1
Bourde, C1
Cepelák, V1
Barcal, R1
Lang, N1
Cepeláková, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessing the Role of the NLRP3 Inflammasome in Driving Inflammation in Affected Joints of Patients With Intercritical Gout[NCT04125459]8 participants (Anticipated)Observational2020-01-22Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for uric acid and Thrombosis

ArticleYear
Polyarticular gout attacks following cerebrovascular accidents: is hemiparesis in fact protective? 2 cases and a review of the literature.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2010, Volume: 16, Issue:6

    Topics: Central Nervous System; Gout; Humans; Male; Middle Aged; Paresis; Rheumatic Diseases; Stroke; Thromb

2010
[The portable hemofiltration-system].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 5

    Topics: Adsorption; Animals; beta 2-Microglobulin; Blood Urea Nitrogen; Creatinine; Endothelial Cells; Hemof

2004

Trials

1 trial available for uric acid and Thrombosis

ArticleYear
Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years.
    The American journal of cardiology, 2007, Jul-01, Volume: 100, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Atherosclerosis; C-Reactive Protein; Cardiovascular Diseases; Cohort

2007

Other Studies

29 other studies available for uric acid and Thrombosis

ArticleYear
Correlation between Left Atrial Thrombosis and Neutrophil-to-Lymphocyte Ratio upon Non-Valvular Atrial Fibrillation.
    Clinical laboratory, 2022, Feb-01, Volume: 68, Issue:2

    Topics: Atrial Fibrillation; Humans; Lymphocytes; Neutrophils; Retrospective Studies; Risk Assessment; Throm

2022
Predictive value of echocardiography combined with CT angiography for left atrial appendage thrombosis in patients with non-valvular atrial fibrillation.
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:21

    Topics: Atrial Appendage; Atrial Fibrillation; Computed Tomography Angiography; Echocardiography, Transesoph

2023
Urate hydroperoxide oxidizes endothelial cell surface protein disulfide isomerase-A1 and impairs adherence.
    Biochimica et biophysica acta. General subjects, 2020, Volume: 1864, Issue:3

    Topics: Catalytic Domain; Cell Adhesion; Cell Membrane; Cell Survival; Chromatography, Liquid; Cysteine; End

2020
Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis.
    Wiener klinische Wochenschrift, 2022, Volume: 134, Issue:3-4

    Topics: Humans; Male; Primary Myelofibrosis; Prognosis; Retrospective Studies; Risk Factors; Thrombosis; Uri

2022
Predictors of high on-aspirin platelet reactivity in elderly patients with coronary artery disease.
    Clinical interventions in aging, 2017, Volume: 12

    Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Coronary Artery Disease; Female; Humans;

2017
Could be serum uric acid a risk factor for thrombosis and/or uveitis in Behcet's disease?
    Vascular, 2018, Volume: 26, Issue:4

    Topics: Adult; Behcet Syndrome; Biomarkers; Female; Humans; Hyperuricemia; Male; Medical Records; Middle Age

2018
Usefulness of the uric acid and CHA₂DS₂-VASc score in prediction of left atrial thrombosis in patients with mitral stenosis and sinus rhythm.
    Cardiology journal, 2015, Volume: 22, Issue:3

    Topics: Adult; Biomarkers; Decision Support Techniques; Echocardiography, Transesophageal; Female; Heart Atr

2015
Serum uric acid concentration and left atrial thrombus: biomarker, pathophysiological indicator, or innocent bystander?
    The Canadian journal of cardiology, 2014, Volume: 30, Issue:11

    Topics: Atrial Fibrillation; Catheter Ablation; Female; Heart Atria; Heart Diseases; Humans; Male; Thrombosi

2014
Serum uric acid and risk of left atrial thrombus in patients with nonvalvular atrial fibrillation.
    The Canadian journal of cardiology, 2014, Volume: 30, Issue:11

    Topics: Atrial Fibrillation; Biomarkers; Catheter Ablation; China; Echocardiography, Transesophageal; Female

2014
Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease.
    Kardiologia polska, 2011, Volume: 69, Issue:4

    Topics: Aged; Biomarkers; Coronary Artery Disease; Diabetes Mellitus; Female; Humans; Hyperuricemia; Inflamm

2011
Uric acid and inflammatory markers.
    European heart journal, 2006, Volume: 27, Issue:10

    Topics: Aged; Aged, 80 and over; Atherosclerosis; Biomarkers; C-Reactive Protein; Cytokines; Female; Humans;

2006
[Place of hyperuricemia and gout in the etiology of retina vascular disorders].
    Angiology, 1967, Volume: 18, Issue:6

    Topics: Female; Gout; Humans; Male; Retinal Hemorrhage; Retinal Vessels; Thrombosis; Uric Acid

1967
Effect of large doses of warfarin sodium on haemostasis and on ADP-induced platelet aggregation in vivo in the rat. A survey of experimental thrombosis and coumarin anticoagulant therapy.
    Cardiovascular research, 1967, Volume: 1, Issue:4

    Topics: Adenine Nucleotides; Animals; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Coumarins

1967
Enhancement of arterial thromboformation by uric acid, a free radical scavenger.
    Biochemical pharmacology, 1982, Sep-15, Volume: 31, Issue:18

    Topics: Adenosine Diphosphate; Animals; Arterial Occlusive Diseases; Epoprostenol; Free Radicals; Photometry

1982
[Long-term hematological management of cyanotic congenital heart diseases].
    Archives des maladies du coeur et des vaisseaux, 1994, Volume: 87, Issue:11

    Topics: Adolescent; Adult; Child; Child, Preschool; Heart Defects, Congenital; Hematologic Diseases; Humans;

1994
Total plasma antioxidant capacity predicts thrombosis-prone status in NIDDM patients.
    Diabetes care, 1997, Volume: 20, Issue:10

    Topics: Antioxidants; Ascorbic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies;

1997
Antithrombotic effect of sulphinpyrazone.
    Lancet (London, England), 1978, May-27, Volume: 1, Issue:8074

    Topics: Animals; Humans; Rabbits; Rats; Sulfinpyrazone; Thrombosis; Uric Acid

1978
[Retinal thromboses with metabolic disturbances (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1978, Volume: 173, Issue:4

    Topics: Adult; Age Factors; Aged; Female; Glucose; Humans; Hyperglycemia; Hyperlipidemias; Hypertension; Lip

1978
[Etiology of retinal venous thromboses].
    Bulletin de la Societe belge d'ophtalmologie, 1976, Mar-07, Volume: 172, Issue:2

    Topics: Adult; Arteriosclerosis; Diabetic Retinopathy; Female; Humans; Hypertension; Retinal Vein; Thrombosi

1976
The effect of free radical scavengers on "in vivo" induced arterial thrombosis in relation to the arachidonate cascade.
    Prostaglandins, leukotrienes, and medicine, 1985, Volume: 18, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Free Radicals; Male; Rats;

1985
[Significance of hyperuricemia in chronic arterial occlusive disease and in post-thrombotic syndrome].
    Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1974, Volume: 40

    Topics: Arterial Occlusive Diseases; Chronic Disease; Humans; Thrombosis; Uric Acid

1974
The Vivacell--a sterile, disposable, high performance, low prime hemodialyzer.
    Transactions - American Society for Artificial Internal Organs, 1973, Volume: 19

    Topics: Biocompatible Materials; Blood Pressure; Cellulose; Creatinine; Disposable Equipment; Humans; Kidney

1973
Bemberg hollow fiber capillary kidney.
    Transactions - American Society for Artificial Internal Organs, 1973, Volume: 19

    Topics: Animals; Blood Flow Velocity; Blood Pressure; Blood Urea Nitrogen; Capillaries; Cellulose; Copper; C

1973
Hyperuricemia in health and disease.
    Seminars in arthritis and rheumatism, 1972,Spring, Volume: 1, Issue:4

    Topics: Arteriosclerosis; Arthritis; Blood Group Antigens; Carbohydrate Metabolism; Diabetes Complications;

1972
[Current problems of gout].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, May-15, Volume: 25, Issue:10

    Topics: Blood Glucose; Cholesterol; Coronary Disease; Diabetes Complications; Female; Gout; Humans; Hypercho

1970
[Participation of uric acid in thromboses of the eye].
    Sbornik lekarsky, 1971, Volume: 73, Issue:7

    Topics: Aged; Blood Pressure Determination; Eye Diseases; Female; Humans; Male; Middle Aged; Sex Factors; Th

1971
Antagonism of the anti-thrombotic effect of warfarin by uric acid.
    The American journal of the medical sciences, 1968, Volume: 256, Issue:1

    Topics: Adenine Nucleotides; Animals; Blood Coagulation; Blood Coagulation Tests; Injections, Intraperitonea

1968
[Hyperuricemia and gout in retinal vascular accidents. New etiological and therapeutic data].
    L'Annee therapeutique et clinique en ophtalmologie, 1963, Volume: 14

    Topics: Adult; Aged; Female; Gout; Humans; Male; Middle Aged; Retinal Hemorrhage; Retinal Vessels; Thromboph

1963
[On the nyctohemeral rhythm in fibrinolysis].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1966, Apr-01, Volume: 21, Issue:7

    Topics: Arginase; Blood Platelets; Esterases; Fibrinolysis; Humans; Oxidoreductases; Periodicity; Thrombelas

1966