Page last updated: 2024-10-20

uric acid and Seizures

uric acid has been researched along with Seizures in 48 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"In this study, we examined the association between serum uric acid levels and epilepsy secondary to cerebral infarction."7.91Serum Uric Acid Is Highly Associated with Epilepsy Secondary to Cerebral Infarction. ( Cheng, F; Dai, Y; Feng, Y; Hu, B; Liu, Z; Sun, J; Wang, D; Zhang, X, 2019)
" In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown."7.83Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016)
"Seizures, often with fatal outcome, are a manifestation of pronounced theophylline intoxication."7.67Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1986)
"RSE was defined as seizure continuing after the first- and second-line treatments."5.51Uric acid is a useful marker to differentiate between responsive and refractory status epilepticus. ( Choi, JY; Hong, JM; Huh, K; Kim, BG; Kim, TJ, 2019)
"This pharmacologic protection trial was conducted to test the hypothesis that allopurinol, a scavenger and inhibitor of oxygen free radical production, could reduce death, seizures, coma, and cardiac events in infants who underwent heart surgery using deep hypothermic circulatory arrest (DHCA)."5.09Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest. ( Clancy, RR; Gaynor, JW; Goin, JE; Hirtz, DG; Jacobs, ML; Mahle, WT; McGaurn, SA; Murphy, JD; Nicolson, SC; Norwood, WI; Spray, TL; Steven, JM; Wernovsky, G, 2001)
"This study aimed to explore the value of serum uric acid levels in differentiating among GTCS, syncope, and PNES by analyzing serum uric acid levels in patients with GTCS, syncope, and PNES."3.91The value of serum uric acid levels to differentiate causes of transient loss of consciousness. ( Hu, H; Jiang, M; Wang, W; Yan, L; Yan, X, 2019)
"In this study, we examined the association between serum uric acid levels and epilepsy secondary to cerebral infarction."3.91Serum Uric Acid Is Highly Associated with Epilepsy Secondary to Cerebral Infarction. ( Cheng, F; Dai, Y; Feng, Y; Hu, B; Liu, Z; Sun, J; Wang, D; Zhang, X, 2019)
" In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown."3.83Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016)
" Univariate analysis revealed statistical significance for the following variables associated with eclampsia: systolic hypertension > or =160 mmHg and diastolic > or =110 mmHg, headache, visual symptoms, vivid deep tendon reflexes, proteinuria >3+ or >3 g d(-1), uric acid concentration > or =350 micromol l(-1), serum creatinine concentration >100 micromol l(-1) and aminotransferase aspartate >30 IU l(-1)."3.72[Risk factors for eclampsia: a case-control study]. ( Arfaoui, C; Ben Salem, F; Ben Salem, K; Faleh, R; Gahbiche, M; Grati, L; Guerdelly, I; Jmel, A, 2003)
" The key findings leading to diagnosis were neonatal seizures unresponsive to treatment, craniofacial dysmorphic features, hyperexcitability, low blood uric acid levels, and neuroimaging findings."3.71Molybdenum cofactor deficiency: report of three cases presenting as hypoxic-ischemic encephalopathy. ( Coskun, T; Haliloglu, G; Saatci, I; Topcu, M, 2001)
"Kainic acid (KA) causes seizures and extensive brain damage in rats."3.70Kainic acid causes redox changes in cerebral cortex extracellular fluid: NMDA receptor activity increases ascorbic acid whereas seizure activity increases uric acid. ( Layton, ME; Pazdernik, TL; Samson, FE, 1998)
"Univariate analysis revealed statistical significance for the following variables associated with eclampsia: uric acid concentration, > 8."3.70Risk factors for abruptio placentae and eclampsia: analysis of 445 consecutively managed women with severe preeclampsia and eclampsia. ( Mattar, F; Saade, GR; Sibai, BM; Witlin, AG, 1999)
"We describe a patient with carnitine-acylcarnitine translocase deficiency (MIM 212138), who presented with neonatal generalized seizures, heart failure, and coma."3.70Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle. ( Dorland, L; Duran, M; IJlst, L; Muntau, AC; Roscher, AA; Röschinger, W; Wanders, RJ, 2000)
"Seizures, often with fatal outcome, are a manifestation of pronounced theophylline intoxication."3.67Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1986)
"Seizures in children with coronavirus disease 2019 (COVID-19) were markedly increased during the Omicron variant surge."1.91Afebrile benign convulsions with or without a reversible splenial lesion in two pediatric patients with COVID-19. ( Kim, YO; Lee, YY, 2023)
"Of those, 80% had generalized seizures, 13."1.72Stroke Characteristics as Predictors of New-onset Seizure in Patients with Acute Ischemic Stroke. ( Ajmal, M; Bhat, NK; Dhar, M; Jose, A; Mohan, L; Saxena, Y, 2022)
"RSE was defined as seizure continuing after the first- and second-line treatments."1.51Uric acid is a useful marker to differentiate between responsive and refractory status epilepticus. ( Choi, JY; Hong, JM; Huh, K; Kim, BG; Kim, TJ, 2019)
"All compounds studied induced clonic convulsion in a dose-dependent manner, and the ED50 values for convulsion were 490, 546, 1107, 360 and 620 nmol/kg for theophylline, 1-MX, 3-MX, 1,3-DMUA and 1-MUA, respectively."1.29Neurotoxic convulsions induced by theophylline and its metabolites in mice. ( Iga, T; Kawakami, J; Sawada, Y; Toyama, E; Yamamoto, K, 1996)
"Cardiazol induced seizures in rabbits showed that the highest oxypurine concentrations can be detected in the CSF 1 hour after the convulsions."1.26Increased nucleotide catabolism after cerebral convulsions. ( Dörner, K; Manzke, H; Staemmler, W, 1981)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-199020 (41.67)18.7374
1990's10 (20.83)18.2507
2000's7 (14.58)29.6817
2010's6 (12.50)24.3611
2020's5 (10.42)2.80

Authors

AuthorsStudies
Lee, HF1
Hsu, CC1
Chi, CS1
Tsai, CR1
Tomomitsu, Y1
Asakawa, S1
Arai, S1
Nagura, M1
Ishizawa, K1
Yamazaki, O1
Tamura, Y1
Uchida, S1
Ohashi, R1
Shibata, S1
Fujigaki, Y1
Lee, YY1
Kim, YO1
Jose, A1
Dhar, M1
Ajmal, M1
Mohan, L1
Saxena, Y1
Bhat, NK1
Jiang, M1
Yan, L1
Yan, X1
Wang, W1
Hu, H1
Mhanni, AA1
Greenberg, CR1
Spriggs, EL1
Agatep, R1
Sisk, RR1
Prasad, C1
Wang, D1
Hu, B1
Dai, Y1
Sun, J1
Liu, Z1
Feng, Y1
Cheng, F1
Zhang, X1
Choi, JY1
Hong, JM1
Kim, TJ1
Kim, BG1
Huh, K1
Thyrion, L2
Raedt, R2
Portelli, J2
Van Loo, P1
Wadman, WJ1
Glorieux, G2
Lambrecht, BN1
Janssens, S1
Vonck, K2
Boon, P2
Larsen, LE1
Sprengers, M1
Van Lysebettens, W1
Carrette, E1
Delbeke, J1
Jurecka, A1
Tylki-Szymanska, A1
Zikanova, M1
Krijt, J1
Kmoch, S1
Tsujita, Y1
Matsumoto, H1
Nakamura, Y1
Nonoyama, S1
SONDERGAARD, E1
PRANGE, I1
DAM, H1
CHRISTENSEN, E1
SALISBURY, PF1
POMERANZ, AA1
Ben Salem, F1
Ben Salem, K1
Grati, L1
Arfaoui, C1
Faleh, R1
Jmel, A1
Guerdelly, I1
Gahbiche, M1
ALTSCHULE, MD1
ALTSCHULE, LH1
TILLOTSON, KJ1
Grisar, T1
Manzke, H1
Staemmler, W1
Dörner, K1
Schattner, A1
Bar-Khaim, Y1
Pohlmann-Eden, B1
Wellhäusser, H1
Stefanou, A1
Schmidt, R1
Schmidt, H1
Siems, WG1
Grune, T1
Grauel, EL1
Yamamoto, K1
Toyama, E1
Kawakami, J1
Sawada, Y1
Iga, T1
Sumi, S1
Wada, Y1
Mayatepek, E1
Koch, HG1
Hoffmann, GF2
Layton, ME1
Samson, FE1
Pazdernik, TL1
Koch, H1
Waring, WS1
Maxwell, S1
Simmonds, HA1
Pérignon, JL1
Micheli, V1
van Gennip, AH1
Witlin, AG1
Saade, GR1
Mattar, F1
Sibai, BM1
Röschinger, W1
Muntau, AC1
Duran, M1
Dorland, L1
IJlst, L1
Wanders, RJ1
Roscher, AA1
Kavukçu, S1
Soylu, A1
Sahin, B1
Türkmen, M1
Aydin, A1
Dirik, E1
Topcu, M1
Coskun, T1
Haliloglu, G1
Saatci, I1
Clancy, RR1
McGaurn, SA1
Goin, JE1
Hirtz, DG1
Norwood, WI1
Gaynor, JW1
Jacobs, ML1
Wernovsky, G1
Mahle, WT1
Murphy, JD1
Nicolson, SC1
Steven, JM1
Spray, TL1
Alvarez Navascués, R1
Marín, R1
Duvina, PL1
Bueno, F1
Mezey, E1
Matsuo, M1
Maeda, E1
Nakamura, H1
Saiki, K1
Ramzan, IM1
Levy, G1
Paulson, GW2
Nance, W1
Son, C1
Son, CD1
Nance, WE1
Berlyne, GM1
Shaw, AB1
Nilwarangkur, S1
Coleman, M2
Landgrebe, M1
Landgrebe, A1
Kelly, S1
Hart, EJ1
Desjardins, L1
Chini, V1
Galli, S1
Quigley, MM1
Morrison, JC1
Whybrew, DW1
Wiser, WL1
Bucovaz, ET1
Fish, SA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation[NCT02519335]Phase 112 participants (Actual)Interventional2014-09-30Terminated (stopped due to PI no longer at this facility)
Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery[NCT04997291]Phase 112 participants (Anticipated)Interventional2021-04-09Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for uric acid and Seizures

ArticleYear
[Xanthine oxidase deficiency (hereditary xanthinuria), molybdenum cofactor deficiency].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:12

    Topics: Central Nervous System Diseases; Coenzymes; Diagnosis, Differential; Diet Therapy; Humans; Infant, N

1996
[Severe maternal complications associated with pre-eclampsia: an almost forgotten pathology?].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2001, Volume: 21, Issue:6

    Topics: Abruptio Placentae; Adult; Anemia, Hemolytic; Case-Control Studies; Cesarean Section; Critical Care;

2001

Trials

1 trial available for uric acid and Seizures

ArticleYear
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001

Other Studies

45 other studies available for uric acid and Seizures

ArticleYear
Genotype-Phenotype Dissociation in Two Taiwanese Children with Molybdenum Cofactor Deficiency Caused by MOCS2 Mutation.
    Neuropediatrics, 2022, Volume: 53, Issue:3

    Topics: Child; Homozygote; Humans; Magnetic Resonance Imaging; Metal Metabolism, Inborn Errors; Movement Dis

2022
A Patient with Acute Kidney Injury Associated with Massive Proteinuria and Acute Hyperuricemia after Epileptic Seizures.
    Internal medicine (Tokyo, Japan), 2022, Nov-15, Volume: 61, Issue:22

    Topics: Acute Kidney Injury; Adult; Epilepsy; Humans; Hyperuricemia; Kidney; Male; Proteinuria; Seizures; Ur

2022
Afebrile benign convulsions with or without a reversible splenial lesion in two pediatric patients with COVID-19.
    BMC pediatrics, 2023, 04-26, Volume: 23, Issue:1

    Topics: Child; COVID-19; Fever; Humans; Infant, Newborn; Magnetic Resonance Imaging; SARS-CoV-2; Seizures; U

2023
Stroke Characteristics as Predictors of New-onset Seizure in Patients with Acute Ischemic Stroke.
    The Journal of the Association of Physicians of India, 2022, Volume: 70, Issue:12

    Topics: Anticonvulsants; Female; Humans; Ischemic Stroke; Male; Middle Aged; Seizures; Stroke; Uric Acid

2022
The value of serum uric acid levels to differentiate causes of transient loss of consciousness.
    Epilepsy & behavior : E&B, 2019, Volume: 99

    Topics: Adult; Aged; Consciousness Disorders; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Re

2019
Isolated sulfite oxidase deficiency: a founder mutation.
    Cold Spring Harbor molecular case studies, 2020, Volume: 6, Issue:6

    Topics: Amino Acid Metabolism, Inborn Errors; Female; Genetic Predisposition to Disease; Humans; Male; Mutat

2020
Serum Uric Acid Is Highly Associated with Epilepsy Secondary to Cerebral Infarction.
    Neurotoxicity research, 2019, Volume: 35, Issue:1

    Topics: Biomarkers; Cerebral Infarction; Epilepsy; Female; Humans; Male; Middle Aged; Risk Factors; Seizures

2019
Uric acid is a useful marker to differentiate between responsive and refractory status epilepticus.
    Clinical neurology and neurosurgery, 2019, Volume: 184

    Topics: Adult; Aged; Anticonvulsants; Biomarkers; Female; Hospitalization; Humans; Intensive Care Units; Mal

2019
Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures.
    Experimental neurology, 2016, Volume: 277

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid

2016
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
    Epilepsia, 2016, Volume: 57, Issue:7

    Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B

2016
D-ribose therapy in four Polish patients with adenylosuccinate lyase deficiency: absence of positive effect.
    Journal of inherited metabolic disease, 2008, Volume: 31 Suppl 2

    Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Blood Glucose; Chi

2008
[Analysis of the blood and serum biochemistry findings in patients demonstrating convulsion with mild gastroenteritis].
    No to hattatsu = Brain and development, 2011, Volume: 43, Issue:4

    Topics: Acidosis; Blood Cell Count; Chlorides; Female; Gastroenteritis; Humans; Infant; Male; Seizures; Uric

2011
Uricemia and kidney damage in galactose-poisoned chicks.
    Acta pathologica et microbiologica Scandinavica, 1957, Volume: 40, Issue:4

    Topics: Animals; Chickens; Galactose; Humans; Kidney; Seizures; Uric Acid

1957
UREMIC TOXICITY CORRELATED WITH UNIDENTIFIED ANIONS.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 114

    Topics: Anions; Blood Chemical Analysis; Creatine; Creatinine; Edema; Glomerulonephritis; Ileostomy; Kidney;

1963
[Risk factors for eclampsia: a case-control study].
    Annales francaises d'anesthesie et de reanimation, 2003, Volume: 22, Issue:10

    Topics: Adult; Analysis of Variance; Aspartate Aminotransferases; Case-Control Studies; Creatinine; Eclampsi

2003
Changes in urinary uric acid-creatinine ratio after electrically induced convulsions in man.
    The Journal of clinical endocrinology and metabolism, 1949, Volume: 9, Issue:6

    Topics: Creatinine; Humans; Male; Seizures; Uric Acid; Urine

1949
Argininosuccinic aciduria in adult: a clinical, electrophysiological and biochemical study.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Age Factors; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinic Acid; Arginin

1982
Increased nucleotide catabolism after cerebral convulsions.
    Neuropediatrics, 1981, Volume: 12, Issue:2

    Topics: Animals; Child; Epilepsy; Female; Humans; Hypoxanthines; Nucleotides; Pentylenetetrazole; Rabbits; S

1981
[Renal damage following encephalitis and convulsions].
    Harefuah, 1981, Volume: 101, Issue:1-2

    Topics: Adult; Encephalitis; Humans; Kidney Diseases; Male; Remission, Spontaneous; Seizures; Uric Acid

1981
[Correlation of serum prolactin and cortisol values with paroxysmal disorders of epileptic and non-epileptic origin and their clinical value].
    Fortschritte der Neurologie-Psychiatrie, 1993, Volume: 61, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Electroencephalography; Epileps

1993
Concentration of purine compounds in the cerebrospinal fluid of infants suffering from sepsis, convulsions and hydrocephalus.
    Journal of perinatal medicine, 1995, Volume: 23, Issue:3

    Topics: Adenine; Bacterial Infections; Chromatography, High Pressure Liquid; Humans; Hydrocephalus; Hypoxant

1995
Neurotoxic convulsions induced by theophylline and its metabolites in mice.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:6

    Topics: Animals; Blood-Brain Barrier; Brain; Infusions, Intravenous; Injections, Intraventricular; Male; Mic

1996
Hyperuricaemia and medium-chain acyl-CoA dehydrogenase deficiency.
    Journal of inherited metabolic disease, 1997, Volume: 20, Issue:6

    Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Blood Glucose; Brain Edema; Female; Humans; Hypogly

1997
Kainic acid causes redox changes in cerebral cortex extracellular fluid: NMDA receptor activity increases ascorbic acid whereas seizure activity increases uric acid.
    Neuropharmacology, 1998, Volume: 37, Issue:2

    Topics: Animals; Antioxidants; Ascorbic Acid; Cerebral Cortex; Excitatory Amino Acid Agonists; Extracellular

1998
Dipsticks and convulsions.
    Lancet (London, England), 1998, Dec-05, Volume: 352, Issue:9143

    Topics: Coenzymes; Diagnostic Errors; Humans; Infant, Newborn; Male; Metalloproteins; Molybdenum Cofactors;

1998
Diagnosis of molybdenum cofactor deficiency.
    Lancet (London, England), 1999, Feb-20, Volume: 353, Issue:9153

    Topics: Antioxidants; Coenzymes; Diagnosis, Differential; Free Radical Scavengers; Free Radicals; Humans; Hy

1999
Diagnosis of molybdenum cofactor deficiency.
    Lancet (London, England), 1999, Feb-20, Volume: 353, Issue:9153

    Topics: Child, Preschool; Coenzymes; Diagnosis, Differential; Humans; Infant; Infant, Newborn; Metalloprotei

1999
Risk factors for abruptio placentae and eclampsia: analysis of 445 consecutively managed women with severe preeclampsia and eclampsia.
    American journal of obstetrics and gynecology, 1999, Volume: 180, Issue:6 Pt 1

    Topics: Abruptio Placentae; Adolescent; Adult; Blood Pressure; Eclampsia; Female; Headache; Humans; Logistic

1999
Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle.
    Clinica chimica acta; international journal of clinical chemistry, 2000, Volume: 298, Issue:1-2

    Topics: Ammonia; Cardiac Output, Low; Carnitine; Carnitine Acyltransferases; Cells, Cultured; Coma; Consangu

2000
Clinical quiz. Molybdenum cofactor deficiency.
    Pediatric nephrology (Berlin, Germany), 2000, Volume: 14, Issue:12

    Topics: Coenzymes; Encephalomalacia; Hematuria; Humans; Infant; Male; Metabolism, Inborn Errors; Metalloprot

2000
Molybdenum cofactor deficiency: report of three cases presenting as hypoxic-ischemic encephalopathy.
    Journal of child neurology, 2001, Volume: 16, Issue:4

    Topics: Coenzymes; Diagnosis, Differential; Female; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn

2001
[9 years of diazoxide therapy in a case of infantile idiopathic hypolglycemia].
    Minerva pediatrica, 1978, Aug-31, Volume: 30, Issue:16

    Topics: Child; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Prediabetic State; Se

1978
[Therapy of alcoholism].
    Der Internist, 1976, Volume: 17, Issue:7

    Topics: Acute Disease; Alcohol Withdrawal Delirium; Alcoholic Intoxication; Alcoholism; Avitaminosis; Chroni

1976
Molybdenum cofactor deficiency: another inborn error of metabolism with neonatal onset.
    Pediatrics, 1988, Volume: 82, Issue:3 Pt 2

    Topics: Coenzymes; Humans; Infant, Newborn; Metabolism, Inborn Errors; Metalloproteins; Molybdenum Cofactors

1988
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Rats; Rats, Inbred Le

1986
Neurologic aspects of typical and atypical Down's syndrome.
    Neurology, 1968, Volume: 18, Issue:3

    Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Down Syndrome; Electroencepha

1968
Neurologic aspects of typical and atypical Down's syndrome.
    Diseases of the nervous system, 1969, Volume: 30, Issue:9

    Topics: Cataract; Chromosome Aberrations; Down Syndrome; Gait; Humans; Hydroxyindoleacetic Acid; Intelligenc

1969
Dietary treatment of chronic renal failure. Experiences with a modified Giovannetti diet.
    Nephron, 1965, Volume: 2, Issue:3

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Aged; Arteritis; Dietary Proteins; Edema; Female;

1965
Progressive seizures with hyperuricosuria reversed by allopurinol.
    Archives of neurology, 1974, Volume: 31, Issue:4

    Topics: Allopurinol; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Humans; Infant; Intel

1974
A new HGPRT-deficient phenotype?
    Journal of medical genetics, 1972, Volume: 9, Issue:4

    Topics: Adolescent; Guanine; Humans; Hypoxanthines; Intellectual Disability; Male; Metabolism, Inborn Errors

1972
[Arterial hypertension with convulsive seizures in a patient with right kidney hypoplasia and gout attacks and with a probable gouty kidney].
    Minerva medica, 1973, Jan-27, Volume: 64, Issue:6

    Topics: Electrocardiography; Gout; Headache; Heart; Humans; Hydronephrosis; Hypertension; Kidney; Kidney Dis

1973
[Behavior of uric acid and urinary ketone bodies in convulsive syndromes in childhood].
    Minerva pediatrica, 1973, Volume: 25, Issue:28

    Topics: Calcium; Child; Child, Preschool; Female; Humans; Infant; Ketone Bodies; Male; Nitrogen; Seizures; U

1973
Acute obstetric yellow atrophy presenting as idiopathic hyperuricemia.
    Southern medical journal, 1974, Volume: 67, Issue:2

    Topics: Acute Kidney Injury; Adult; Blood Coagulation Tests; Bronchopneumonia; Cytoplasm; Diagnosis, Differe

1974
Laboratory characteristics in toxemia.
    Obstetrics and gynecology, 1972, Volume: 39, Issue:6

    Topics: Blood Glucose; Blood Proteins; Calcium; Cerebrospinal Fluid Proteins; Color; Erythrocytes; Female; G

1972
Reversal of organic brain syndrome with seizures and hyperuricosuria subsequent to allopurinol therapy.
    Transactions of the American Neurological Association, 1971, Volume: 96

    Topics: Allopurinol; Brain Damage, Chronic; Child; Electroencephalography; Humans; Male; Purine-Pyrimidine M

1971