uric acid and Reperfusion Injury studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

Excerpt	Relevance	Reference
"For the first time, this study revealed that atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative injury, inflammation, and apoptosis induced by ovarian ischaemia/reperfusion injury."	8.12	Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury. ( Adeyemi, DH; Afolabi, OA; Akhigbe, RE; Anyogu, DC; Hamed, MA; Odetayo, AF, 2022)
"Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages."	7.83	Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits. ( Adam, B; Akyol, O; Akyol, S; Erdemli, HK; Gulec, MA; Pehlivan, S; Yuksel, S, 2016)
"The present study investigated the role of N-methyl-d-aspartate (NMDA) receptors in curcumin-mediated renoprotection against ischemia reperfusion (I/R)-induced acute kidney injury (AKI) in rats."	7.83	Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats. ( Kaur, A; Kaur, T; Pal Singh, A; Pathak, D; Singh Buttar, H; Singh, B, 2016)
"I/R caused alterations in diuresis, water intake, urinary osmolality, plasmatic creatinine, urea and uric acid, creatinine clearance, proteinuria and microalbuminuria."	7.83	Nephroprotective effects of (-)-α-bisabolol against ischemic-reperfusion acute kidney injury. ( Alves, RS; Arrieta, MC; Chaves Filho, AJ; da Costa, MF; de Morais, GB; Evangelista, JS; Libório, AB; Martins, AM; Meneses, GC; Menezes, RR; Sampaio, TL, 2016)
"The aim of this study was to evaluate the effect of allopurinol, methylene blue, and a monoclonal antibody to the adhesion molecule ICAM-1 in intestinal ischemia and reperfusion injury."	7.72	Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury. ( Alatas, O; çOlak, O; Ilhan, H; Koku, N; Paşaoĝlu, O; Tokar, B, 2003)
"The purpose of this study was to evaluate the possible involvement of xanthine and xanthine oxidase in reperfusion injury in a low-flow, reflow model of liver perfusion."	7.67	Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver. ( Lemasters, JJ; Thurman, RG; Zhong, Z, 1989)
"Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O2(-)), in humans."	6.45	Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders? ( Nozaki, S; Onuma, M; Suzuki, I; Yamauchi, T, 2009)
"After establishing middle cerebral artery occlusion of male rats with suture method, damage and increase of ROS production in brain tissue could be seen, and after adding suitable concentration of uric acid, the degree of brain damage and ROS production was reduced."	5.46	Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury. ( Lin, SP; Yang, N; Zhang, B; Zhang, F, 2017)
"Gallic acid is a polyphenolic compound and is reported to be renoprotective because of its antioxidant activity in various preclinical studies."	5.40	Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats. ( Bhatti, R; Singh, AP; Singh, JP, 2014)
" We hypothesized that asymptomatic HU would attenuate AKD because soluble, in contrast to crystalline, uric acid (sUA) can attenuate sterile inflammation."	4.12	Asymptomatic Hyperuricemia Promotes Recovery from Ischemic Organ Injury by Modulating the Phenotype of Macrophages. ( Anders, HJ; Carangelo, G; De Chiara, L; Gnemmi, V; Li, C; Li, Q; Ma, Q; Molina-Van den Bosch, M; Romagnani, P; Steiger, S, 2022)
"For the first time, this study revealed that atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative injury, inflammation, and apoptosis induced by ovarian ischaemia/reperfusion injury."	4.12	Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury. ( Adeyemi, DH; Afolabi, OA; Akhigbe, RE; Anyogu, DC; Hamed, MA; Odetayo, AF, 2022)
"The present study investigated the role of N-methyl-d-aspartate (NMDA) receptors in curcumin-mediated renoprotection against ischemia reperfusion (I/R)-induced acute kidney injury (AKI) in rats."	3.83	Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats. ( Kaur, A; Kaur, T; Pal Singh, A; Pathak, D; Singh Buttar, H; Singh, B, 2016)
"Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages."	3.83	Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits. ( Adam, B; Akyol, O; Akyol, S; Erdemli, HK; Gulec, MA; Pehlivan, S; Yuksel, S, 2016)
"I/R caused alterations in diuresis, water intake, urinary osmolality, plasmatic creatinine, urea and uric acid, creatinine clearance, proteinuria and microalbuminuria."	3.83	Nephroprotective effects of (-)-α-bisabolol against ischemic-reperfusion acute kidney injury. ( Alves, RS; Arrieta, MC; Chaves Filho, AJ; da Costa, MF; de Morais, GB; Evangelista, JS; Libório, AB; Martins, AM; Meneses, GC; Menezes, RR; Sampaio, TL, 2016)
"In this study, blood redox potential (ORP) values (ΔORP value was adopted, as the quantitative index to reflect the overall redox status), plasma uric acid levels (important antioxidant, as antioxidant index), and the burn shock state-related indicators (lactic acid and hematocrit) of 48 burn patients were dynamically, quantitatively monitored during the early stage after injury."	3.81	The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. ( Han, C; Hu, H; Hu, X; Pan, X; Shao, H; Xu, J; Yu, C; Zhi, L, 2015)
"We demonstrated that 3-nitrotyrosine and 4-hydroxy-2-nonenal levels in mouse brain were elevated from 1 h until 8 h after global brain ischemia for 14 min induced with the 3-vessel occlusion model; this result indicates that ischemia reperfusion injury generated oxidative stress."	3.81	The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice. ( Fuse, A; Kusano, T; Matsuda, Y; Okamoto, K; Suzuki, G; Yamaguchi, M; Yokota, H, 2015)
" The creatinine clearance, serum urea, uric acid, lactate dehydrogenase, potassium, fractional excretion of sodium, and microproteinuria were measured to assess kidney injury."	3.80	Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. ( Arora, S; Brar, R; Kaur, T; Singh, AP; Singh, JP, 2014)
" Levels of uric acid, one of the prototypical "alarm signals," surge after ischemia-reperfusion injury."	3.74	Ischemia-induced exocytosis of Weibel-Palade bodies mobilizes stem cells. ( Addabbo, F; Cohen-Gould, L; Goligorsky, MS; Kuo, MC; Ni, J; Park, HC; Patschan, D; Patschan, S, 2008)
"The aim of this study was to evaluate the effect of allopurinol, methylene blue, and a monoclonal antibody to the adhesion molecule ICAM-1 in intestinal ischemia and reperfusion injury."	3.72	Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury. ( Alatas, O; çOlak, O; Ilhan, H; Koku, N; Paşaoĝlu, O; Tokar, B, 2003)
" Renal and ischemia/reperfusion injury parameters were studied, as well as malondialdehyde as a parameter for oxidative stress."	3.71	Off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function. ( Aarts, LP; Driessen, AH; Gerritsen, WB; Haas, FJ; van Boven, WJ, 2001)
"Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation."	3.70	Evaluation of serum uric acid changes in different forms of hepatic vascular inflow occlusion in human liver surgeries. ( Ikarashi, Y; Ishizaki, M; Kogure, K; Kuwano, H; Makuuchi, M; Maruyama, Y; Nemoto, M; Tatemoto, K, 1999)
" Furthermore, 5 days of allopurinol treatment (25 mg/kg iv twice daily) starting 2 days before ischemia or 3 days of oxypurinol treatment (25 mg/kg iv twice daily) starting 15 min before reperfusion did not attenuate the extent of skeletal muscle necrosis in pig LD muscles subjected to 5 h of ischemia and 48 h of reperfusion."	3.68	Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human. ( Boyd, B; Chiu, C; Dorion, D; Forrest, CR; Pang, CY; Zhong, A, 1993)
"We investigated whether stimulation of bile flow by taurocholic acid (TCA), ursodeoxycholic acid (UDCA) or its taurine conjugate (TUDCA) could protect the liver from ischemia-reperfusion injury."	3.68	Effect of bile acids on ischemia-reperfusion liver injury. ( Ballet, F; Bonnefis, MT; Chazouillères, O; Chrétien, Y; Legendre, C; Poupon, R; Rey, C, 1991)
"The purpose of this study was to evaluate the possible involvement of xanthine and xanthine oxidase in reperfusion injury in a low-flow, reflow model of liver perfusion."	3.67	Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver. ( Lemasters, JJ; Thurman, RG; Zhong, Z, 1989)
"Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O2(-)), in humans."	2.45	Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders? ( Nozaki, S; Onuma, M; Suzuki, I; Yamauchi, T, 2009)
"However, ischaemia reperfusion injury remains a barrier to achieving better survival outcomes."	1.91	Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation. ( Baciu, C; Cypel, M; Hsin, M; Keshavjee, S; Liu, M; Shin, J, 2023)
"After establishing middle cerebral artery occlusion of male rats with suture method, damage and increase of ROS production in brain tissue could be seen, and after adding suitable concentration of uric acid, the degree of brain damage and ROS production was reduced."	1.46	Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury. ( Lin, SP; Yang, N; Zhang, B; Zhang, F, 2017)
"Gallic acid is a polyphenolic compound and is reported to be renoprotective because of its antioxidant activity in various preclinical studies."	1.40	Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats. ( Bhatti, R; Singh, AP; Singh, JP, 2014)
"carota root extract on renal ischemia reperfusion injury in rats."	1.39	Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats. ( Afzal, M; Ahmad, A; Anwar, F; Kaur, R; Kazmi, I; Pravez, M, 2013)
"Chronic hypoxic pulmonary hypertension is characterized by vasoconstriction and vascular remodeling and impaired endothelial nitric oxide (NO) production."	1.35	Ischemic and peroxynitrite preconditioning effects in chronic hypoxic rat lung. ( Demiryurek, AT; Gumusel, B; Turan, NN; Yildiz, G, 2008)
"Uric acid release was minimal during reperfusion."	1.35	Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection. ( Bast, A; Dejong, CH; Fischer, MA; Koek, GH; van de Poll, MC, 2008)
"Allantoin levels were low in both the control and CI groups."	1.33	H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. ( Freise, CE; Fuller, TF; Klawitter, J; Niemann, CU; Serkova, N, 2005)
"Lung malondialdehyde (MDA) levels were significantly depressed in ischaemic and ONOO(-) preconditioning groups."	1.33	Preconditioning effects of peroxynitrite in the rat lung. ( Demiryürek, AT; Turan, NN, 2006)

Research

Studies (68)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Number of Participants With Delayed Recovery of Liver Function

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.47)	18.7374
1990's	15 (22.06)	18.2507
2000's	25 (36.76)	29.6817
2010's	20 (29.41)	24.3611
2020's	7 (10.29)	2.80

Authors	Studies
Gnemmi, V	1
Li, Q	2
Ma, Q	2
De Chiara, L	1
Carangelo, G	1
Li, C	2
Molina-Van den Bosch, M	1
Romagnani, P	1
Anders, HJ	1
Steiger, S	1
Baciu, C	1
Shin, J	1
Hsin, M	1
Cypel, M	1
Keshavjee, S	1
Liu, M	1
Afolabi, OA	1
Hamed, MA	2
Anyogu, DC	1
Adeyemi, DH	1
Odetayo, AF	2
Akhigbe, RE	2
Cheng, GM	1
Wang, RL	1
Zhang, B	2
Deng, XY	1
Liu, HQ	1
Li, J	8
Liu, XL	1
Zhao, X	1
Ma, HC	1
Nguépy Keubo, FR	1
Mboua, PC	1
Djifack Tadongfack, T	1
Fokouong Tchoffo, E	1
Tasson Tatang, C	1
Ide Zeuna, J	1
Noupoue, EM	1
Tsoplifack, CB	1
Folefack, GO	1
Kettani, M	1
Bandelier, P	1
Huo, J	1
Li, H	4
Yu, D	1
Arulsamy, N	1
AlAbbad, S	1
Sardot, T	1
Lekashvili, O	1
Decato, D	1
Lelj, F	1
Alexander Ross, JB	1
Rosenberg, E	1
Nazir, H	1
Muthuswamy, N	1
Louis, C	1
Jose, S	1
Prakash, J	1
Buan, MEM	1
Flox, C	1
Chavan, S	1
Shi, X	1
Kauranen, P	1
Kallio, T	1
Maia, G	1
Tammeveski, K	1
Lymperopoulos, N	1
Carcadea, E	1
Veziroglu, E	1
Iranzo, A	1
M Kannan, A	1
Arunamata, A	1
Tacy, TA	1
Kache, S	1
Mainwaring, RD	1
Ma, M	1
Maeda, K	1
Punn, R	1
Noguchi, S	1
Hahn, S	3
Iwasa, Y	3
Ling, J	2
Voccio, JP	2
Kim, Y	3
Song, J	3
Bascuñán, J	2
Chu, Y	1
Tomita, M	1
Cazorla, M	1
Herrera, E	1
Palomeque, E	1
Saud, N	1
Hoplock, LB	1
Lobchuk, MM	1
Lemoine, J	1
Li, X	10
Henson, MA	1
Unsihuay, D	1
Qiu, J	1
Swaroop, S	1
Nagornov, KO	1
Kozhinov, AN	1
Tsybin, YO	1
Kuang, S	1
Laskin, J	1
Zin, NNINM	1
Mohamad, MN	1
Roslan, K	1
Abdul Wafi, S	1
Abdul Moin, NI	1
Alias, A	1
Zakaria, Y	1
Abu-Bakar, N	1
Naveed, A	1
Jilani, K	1
Siddique, AB	1
Akbar, M	1
Riaz, M	1
Mushtaq, Z	1
Sikandar, M	1
Ilyas, S	1
Bibi, I	1
Asghar, A	1
Rasool, G	1
Irfan, M	1
Li, XY	1
Zhao, S	1
Fan, XH	1
Chen, KP	1
Hua, W	1
Liu, ZM	1
Xue, XD	1
Zhou, B	1
Zhang, S	2
Xing, YL	1
Chen, MA	1
Sun, Y	1
Neradilek, MB	1
Wu, XT	1
Zhang, D	2
Huang, W	1
Cui, Y	1
Yang, QQ	1
Li, HW	1
Zhao, XQ	1
Hossein Rashidi, B	1
Tarafdari, A	1
Ghazimirsaeed, ST	1
Shahrokh Tehraninezhad, E	1
Keikha, F	1
Eslami, B	1
Ghazimirsaeed, SM	1
Jafarabadi, M	1
Silvani, Y	1
Lovita, AND	1
Maharani, A	1
Wiyasa, IWA	1
Sujuti, H	1
Ratnawati, R	1
Raras, TYM	1
Lemin, AS	1
Rahman, MM	1
Pangarah, CA	1
Kiyu, A	1
Zeng, C	2
Du, H	1
Lin, D	1
Jalan, D	1
Rubagumya, F	1
Hopman, WM	1
Vanderpuye, V	1
Lopes, G	1
Seruga, B	1
Booth, CM	1
Berry, S	1
Hammad, N	1
Sajo, EA	1
Okunade, KS	1
Olorunfemi, G	1
Rabiu, KA	1
Anorlu, RI	1
Xu, C	2
Xiang, Y	1
Xu, X	1
Zhou, L	2
Dong, X	1
Tang, S	1
Gao, XC	1
Wei, CH	1
Zhang, RG	1
Cai, Q	1
He, Y	1
Tong, F	1
Dong, JH	1
Wu, G	1
Dong, XR	1
Tang, X	1
Tao, F	1
Xiang, W	1
Zhao, Y	2
Jin, L	1
Tao, H	1
Lei, Y	1
Gan, H	1
Huang, Y	1
Chen, Y	3
Chen, L	3
Shan, A	1
Zhao, H	2
Wu, M	2
Wang, J	4
Zhang, E	1
Zhang, J	3
Li, Y	5
Xue, F	1
Deng, L	1
Liu, L	2
Yan, Z	2
Wang, Y	2
Meng, J	1
Chen, G	2
Anastassiadou, M	1
Bernasconi, G	1
Brancato, A	1
Carrasco Cabrera, L	1
Greco, L	1
Jarrah, S	1
Kazocina, A	1
Leuschner, R	1
Magrans, JO	1
Miron, I	1
Nave, S	1
Pedersen, R	1
Reich, H	1
Rojas, A	1
Sacchi, A	1
Santos, M	1
Theobald, A	1
Vagenende, B	1
Verani, A	1
Du, L	1
Liu, X	1
Ren, Y	1
Li, P	1
Jiao, Q	1
Meng, P	1
Wang, F	2
Wang, YS	1
Wang, C	3
Zhou, X	2
Wang, W	1
Wang, S	2
Hou, J	1
Zhang, A	1
Lv, B	1
Gao, C	1
Pang, D	1
Lu, K	1
Ahmad, NH	1
Wang, L	1
Zhu, J	2
Zhang, L	2
Zhuang, T	1
Tu, J	1
Zhao, Z	1
Qu, Y	1
Yao, H	1
Wang, X	5
Lee, DF	1
Shen, J	3
Wen, L	1
Huang, G	2
Xie, X	1
Zhao, Q	1
Hu, W	1
Zhang, Y	4
Wu, X	1
Lu, J	2
Li, M	1
Li, W	2
Wu, W	1
Du, F	1
Ji, H	1
Yang, X	2
Xu, Z	1
Wan, L	1
Wen, Q	1
Cho, CH	1
Zou, C	1
Xiao, Z	1
Liao, J	1
Su, X	1
Bi, Z	1
Su, Q	1
Huang, H	1
Wei, Y	2
Gao, Y	2
Na, KJ	1
Choi, H	1
Oh, HR	1
Kim, YH	1
Lee, SB	1
Jung, YJ	1
Koh, J	1
Park, S	1
Lee, HJ	1
Jeon, YK	1
Chung, DH	1
Paeng, JC	1
Park, IK	1
Kang, CH	1
Cheon, GJ	1
Kang, KW	1
Lee, DS	1
Kim, YT	1
Pajuelo-Lozano, N	1
Alcalá, S	1
Sainz, B	1
Perona, R	1
Sanchez-Perez, I	1
Logotheti, S	1
Marquardt, S	1
Gupta, SK	1
Richter, C	1
Edelhäuser, BAH	1
Engelmann, D	1
Brenmoehl, J	1
Söhnchen, C	1
Murr, N	1
Alpers, M	1
Singh, KP	1
Wolkenhauer, O	1
Heckl, D	1
Spitschak, A	1
Pützer, BM	1
Liao, Y	1
Cheng, J	1
Kong, X	1
Li, S	1
Zhang, M	4
Zhang, H	1
Yang, T	2
Dong, Y	1
Xu, Y	1
Yuan, Z	1
Cao, J	1
Zheng, Y	1
Luo, Z	1
Mei, Z	1
Yao, Y	1
Liu, Z	2
Liang, C	1
Yang, H	1
Song, Y	1
Yu, K	1
Zhu, C	1
Huang, Z	1
Qian, J	1
Ge, J	1
Hu, J	2
Wang, H	2
Liu, Y	4
Mi, Y	1
Kong, H	1
Xi, D	1
Yan, W	1
Luo, X	1
Ning, Q	1
Chang, X	2
Zhang, T	2
Wang, Q	2
Rathore, MG	1
Reddy, K	1
Chen, H	1
Shin, SH	1
Ma, WY	1
Bode, AM	1
Dong, Z	1
Mu, W	1
Liu, C	3
Gao, F	1
Qi, Y	1
Lu, H	1
Zhang, X	4
Cai, X	1
Ji, RY	1
Hou, Y	3
Tian, J	2
Shi, Y	1
Ying, S	1
Tan, M	1
Feng, G	1
Kuang, Y	1
Chen, D	1
Wu, D	3
Zhu, ZQ	1
Tang, HX	1
Shi, ZE	1
Kang, J	1
Liu, Q	1
Qi, J	2
Mu, J	1
Cong, Z	1
Chen, S	2
Fu, D	1
Li, Z	2
Celestrin, CP	1
Rocha, GZ	1
Stein, AM	1
Guadagnini, D	1
Tadelle, RM	1
Saad, MJA	1
Oliveira, AG	1
Bianconi, V	1
Bronzo, P	1
Banach, M	1
Sahebkar, A	1
Mannarino, MR	1
Pirro, M	1
Patsourakos, NG	1
Kouvari, M	1
Kotidis, A	1
Kalantzi, KI	1
Tsoumani, ME	1
Anastasiadis, F	1
Andronikos, P	1
Aslanidou, T	1
Efraimidis, P	1
Georgiopoulos, A	1
Gerakiou, K	1
Grigoriadou-Skouta, E	1
Grigoropoulos, P	1
Hatzopoulos, D	1
Kartalis, A	1
Lyras, A	1
Markatos, G	1
Mikrogeorgiou, A	1
Myroforou, I	1
Orkopoulos, A	1
Pavlidis, P	1
Petras, C	1
Riga, M	1
Skouloudi, M	1
Smyrnioudis, N	1
Thomaidis, K	1
Tsikouri, GE	1
Tsikouris, EI	1
Zisimos, K	1
Vavoulis, P	1
Vitali, MG	1
Vitsas, G	1
Vogiatzidis, C	1
Chantanis, S	1
Fousas, S	1
Panagiotakos, DB	1
Tselepis, AD	1
Jungen, C	1
Alken, FA	1
Eickholt, C	1
Scherschel, K	1
Kuklik, P	1
Klatt, N	1
Schwarzl, J	1
Moser, J	1
Jularic, M	1
Akbulak, RO	1
Schaeffer, B	1
Willems, S	1
Meyer, C	1
Nowak, JK	1
Szczepanik, M	1
Trypuć, M	1
Pogorzelski, A	1
Bobkowski, W	1
Grytczuk, M	1
Minarowska, A	1
Wójciak, R	1
Walkowiak, J	1
Lu, Y	1
Xi, J	1
Chen, W	2
Hu, X	3
Zhang, F	2
Wei, H	1
Wang, Z	1
Gurzu, S	1
Jung, I	1
Sugimura, H	2
Stefan-van Staden, RI	1
Yamada, H	1
Natsume, H	1
Iwashita, Y	1
Szodorai, R	1
Szederjesi, J	1
Yari, D	1
Ehsanbakhsh, Z	1
Validad, MH	1
Langroudi, FH	1
Esfandiari, H	1
Prager, A	1

Trial	Enrollment	Study Type	Start Date	Status
Reperfusion-induced Self-antigen Excretion Following Major Liver Surgery[NCT01700660]	40 participants (Actual)	Observational	2012-10-31	Completed
The DIEP-Flap as a Model of Ischemia-Reperfusion[NCT00482469]	45 participants (Actual)	Observational	2007-04-30	Completed
The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial[NCT03386435]	160 participants (Actual)	Interventional	2016-08-22	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The incidence of delayed recovery of hepatic function (DRHF) were used as surrogate parameters indicating the possible benefits of RIPC. DRHF was defined based on a proposal by the International Study Group of Liver Surgery, as follows: an impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased PT INR and concomitant hyperbilirubinemia (considering the normal limits of the local laboratory) on or after postoperative day 5. The normal upper limits of PT and bilirubin in our institutional laboratory were 1.30 INR and 1.2 mg/dL, respectively. If either the PT INR or serum bilirubin concentration was preoperatively elevated, DRHF was defined by an increasing PT INR and increasing serum bilirubin concentration on or after postoperative day 5 (compared with the values of the previous day). (NCT03386435)
Timeframe: postoperative 7 days

Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days

Intervention	Participants (Count of Participants)
RIPC	5
Control	0

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal aspartate aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy. (NCT03386435)
Timeframe: within 7 days after operation

Postoperative Liver Regeneration

Intervention	IU/L (Mean)
RIPC	145
Control	152

The postoperative liver regeneration index (LRI) at postoperative 1 month ) was used as surrogate parameters indicating the possible benefits of RIPC. The LRI was defined as [(VLR - VFLR)/VFLR)] × 100, where VLR is the volume of the liver remnant and VFLR is the volume of the future liver remnant. Liver volume was calculated by CT volumetry using 3-mm-thick dynamic CT images. The graft weight was subtracted from the total liver volume to define the future liver remnant. (NCT03386435)
Timeframe: 1 month

The Maximal Alanine Aminotransferase Level Within 7 Postoperative Days

Intervention	percentage of liver volume (Mean)
RIPC	83.3
Control	94.9

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal alanine aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy (NCT03386435)
Timeframe: within 7 days after operation

Article	Year
Folic acid and RAAS blockers in ischemia/reperfusion-induced hepatic injury: A current mechanistic concept for understanding the incidence, significance & outcome. Chemico-biological interactions, 2020, Aug-25, Volume: 327 Topics: Animals; Drug Synergism; Folic Acid; Homocysteine; Humans; Liver Diseases; Renin-Angiotensin System;	2020
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Endothelial injury, alarmins, and allograft rejection. Critical reviews in immunology, 2008, Volume: 28, Issue:3 Topics: Endothelium, Vascular; Graft Rejection; HMGB1 Protein; Humans; Interleukin-1alpha; Interleukin-1beta	2008
Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders? Drugs of today (Barcelona, Spain : 1998), 2009, Volume: 45, Issue:5 Topics: Allopurinol; Enzyme Inhibitors; Fatty Liver; Humans; Liver Diseases; Metabolic Syndrome; Mucositis;	2009
The sterile immune response during hepatic ischemia/reperfusion. Cytokine & growth factor reviews, 2012, Volume: 23, Issue:3 Topics: Adenosine Triphosphate; Dendritic Cells; DNA; Hepatitis; Hepatocytes; HMGB1 Protein; Humans; Immunit	2012
Sterile inflammation in the liver. Gastroenterology, 2012, Volume: 143, Issue:5 Topics: Acetaminophen; Adenosine Triphosphate; Caspase 1; Chemical and Drug Induced Liver Injury; Chemotaxis	2012
Uric acid and oxidative stress. Current pharmaceutical design, 2005, Volume: 11, Issue:32 Topics: Animals; Antioxidants; Humans; Laparoscopy; Oxidative Stress; Reperfusion Injury; Uric Acid; Xanthin	2005
Ischemic-reperfusion syndromes: biochemical and immunologic rationale for IL-1 targeted therapy. Clinical immunology (Orlando, Fla.), 2008, Volume: 128, Issue:2 Topics: Animals; Calcium Pyrophosphate; Carrier Proteins; Cytoskeletal Proteins; Humans; Inflammation; Inter	2008
[Xanthine oxidase (xanthine dehydrogenase)]. Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:12 Topics: DNA; Humans; Hypoxanthine; Protein Conformation; Reperfusion Injury; Superoxides; Uric Acid; Xanthin	1996
The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction. Microcirculation (New York, N.Y. : 1994), 2002, Volume: 9, Issue:3 Topics: Animals; Endothelium, Vascular; Humans; Reperfusion Injury; Signal Transduction; Uric Acid; Vasculit	2002

Article	Year
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Ischemic pre-conditioning in deceased donor liver transplantation: a prospective randomized clinical trial. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, Volume: 7, Issue:9 Topics: Apoptosis; Aspartate Aminotransferases; Biomarkers; Blotting, Western; Caspase 3; Female; Follow-Up	2007

Article	Year
Asymptomatic Hyperuricemia Promotes Recovery from Ischemic Organ Injury by Modulating the Phenotype of Macrophages. Cells, 2022, 02-11, Volume: 11, Issue:4 Topics: Acute Kidney Injury; Animals; Humans; Hyperuricemia; Inflammation; Ischemia; Macrophages; Mice; Phen	2022
Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation. Thorax, 2023, Volume: 78, Issue:3 Topics: Humans; Inosine; Lung; Lung Transplantation; Reperfusion; Reperfusion Injury; Uric Acid	2023
Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury. Redox report : communications in free radical research, 2022, Volume: 27, Issue:1 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Atorvastatin; Caspase 3; Down-Regulat	2022
The protective effect of uric acid in reducing TLR4/NF-κB activation through the inhibition of HMGB1 acetylation in a model of ischemia-reperfusion injury in vitro. Molecular biology reports, 2020, Volume: 47, Issue:4 Topics: Acetylation; Animals; Apoptosis; Cell Line; Gene Expression Regulation; HMGB1 Protein; Inflammation;	2020
Omega-3 fatty acid rescues ischaemia/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase/uric acid signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 142 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Fatty Acids, Omega-3; Lactates; Male; Ra	2021
Estradiol mediates the long-lasting lung inflammation induced by intestinal ischemia and reperfusion. The Journal of surgical research, 2018, Volume: 221 Topics: Animals; Cytokines; Estradiol; Female; Intestinal Diseases; Intestines; Leukocyte Count; Lung; Lung	2018
The reliability of clinical dynamic monitoring of redox status using a new redox potential (ORP) determination method. Redox report : communications in free radical research, 2013, Volume: 18, Issue:2 Topics: Abbreviated Injury Scale; Adult; Ascorbic Acid; Blood Chemical Analysis; Burns; Electrochemistry; El	2013
Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats. Pharmaceutical biology, 2013, Volume: 51, Issue:7 Topics: Acute Kidney Injury; Administration, Oral; Animals; Creatinine; Daucus carota; Disease Models, Anima	2013
Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats. The Journal of surgical research, 2013, Volume: 185, Issue:2 Topics: Acute Kidney Injury; Animals; Calcium; Creatinine; Disease Models, Animal; L-Lactate Dehydrogenase;	2013
Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:2 Topics: Acute Kidney Injury; Animals; Catalase; Creatinine; GABA Agents; Glutathione; Kidney; L-Lactate Dehy	2014
Involvement of progesterone receptors in ascorbic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury. The Journal of surgical research, 2014, Volume: 187, Issue:1 Topics: Acute Kidney Injury; Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Rel	2014
Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats. The Journal of surgical research, 2014, Volume: 187, Issue:2 Topics: Acute Kidney Injury; Animals; Antioxidants; Benzhydryl Compounds; Blood Urea Nitrogen; Carcinogens;	2014
Methylene blue attenuates ischemia--reperfusion injury in lung transplantation. The Journal of surgical research, 2014, Volume: 192, Issue:2 Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cold Ischemia; Cytokines; Disease Models, Anima	2014
The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. The American journal of emergency medicine, 2015, Volume: 33, Issue:3 Topics: Adult; Burns; Case-Control Studies; Cohort Studies; Disease Progression; Hematocrit; Humans; Hypoxia	2015
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice. PloS one, 2015, Volume: 10, Issue:7 Topics: Aldehydes; Allopurinol; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Interleu	2015
Study on the effect of black cumin (Nigella sativa Linn.) on experimental renal ischemia-reperfusion injury in rats. Acta cirurgica brasileira, 2015, Volume: 30, Issue:8 Topics: Animals; Blood Urea Nitrogen; Creatinine; Kidney; Kidney Function Tests; Male; Malondialdehyde; Nige	2015
Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits. Medical hypotheses, 2016, Volume: 92 Topics: Animals; Antioxidants; Brain; Carbon Monoxide; Carbon Monoxide Poisoning; Central Nervous System; Hu	2016
Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats. Renal failure, 2016, Volume: 38, Issue:9 Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Curcumin; Disease Models, Animal; Enz	2016
Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury. Cellular and molecular neurobiology, 2017, Volume: 37, Issue:5 Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Line; Cell Proliferation; Cell Survival; Disease Mod	2017
Nephroprotective effects of (-)-α-bisabolol against ischemic-reperfusion acute kidney injury. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Dec-15, Volume: 23, Issue:14 Topics: Acute Kidney Injury; Animals; Antioxidants; Cell Adhesion Molecules; Chamomile; Fluoresceins; Glutat	2016
Ischemic and peroxynitrite preconditioning effects in chronic hypoxic rat lung. Experimental lung research, 2008, Volume: 34, Issue:6 Topics: Animals; Chronic Disease; Drug Antagonism; Drug Therapy, Combination; Enzyme Inhibitors; Hypertensio	2008
Antioxidant defense in hepatic ischemia-reperfusion injury is regulated by damage-associated molecular pattern signal molecules. Free radical biology & medicine, 2008, Oct-15, Volume: 45, Issue:8 Topics: Adenosine Triphosphate; Animals; Antioxidants; Blotting, Western; HMGB1 Protein; Immunohistochemistr	2008
Ischemia-induced exocytosis of Weibel-Palade bodies mobilizes stem cells. Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:12 Topics: Angiopoietin-2; Cells, Cultured; Exocytosis; Hematopoietic Stem Cells; Humans; Interleukin-8; Ischem	2008
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase. Journal of dermatological science, 2009, Volume: 55, Issue:2 Topics: Biomarkers; Cell Hypoxia; Cell Line; Cell Survival; Glucose; Glutathione; Glutathione Disulfide; Hum	2009
Influence on energy kinetics and histology of different preservation solutions seen during cold ischemia in the liver. Transplantation proceedings, 2009, Volume: 41, Issue:10 Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Allopurinol; Animals; Energy Metabolism;	2009
Clinical evidence of the association between serum perioperative changes in xanthine metabolizing enzymes activity and early post-transplant kidney allograft function. Journal of the American College of Surgeons, 2010, Volume: 211, Issue:5 Topics: Area Under Curve; Biomarkers; Delayed Graft Function; Female; Graft Survival; Humans; Kidney Transpl	2010
Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2012, Volume: 15, Issue:2 Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Tr	2012
The role of antioxidants in ischaemia-reperfusion in a human DIEP flap model. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2012, Volume: 65, Issue:12 Topics: Antioxidants; Biopsy; Epigastric Arteries; Female; Glutathione; Humans; Mammaplasty; Perforator Flap	2012
Influence of peroxynitrite on energy metabolism and cardiac function in a rat ischemia-reperfusion model. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:4 Topics: Animals; beta-Galactosidase; Cardiotonic Agents; Cell Membrane; Creatine Kinase; Energy Metabolism;	2003
Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury. Journal of pediatric surgery, 2003, Volume: 38, Issue:11 Topics: Allopurinol; Animals; Antibodies, Monoclonal; Drug Evaluation, Preclinical; Ileum; Intercellular Adh	2003
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:2 Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Res	2004
Protective effects of exogenous fructose-1,6-biphosphate during small bowel transplantation in rats. Surgery, 2004, Volume: 135, Issue:5 Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Bacterial Translocation; Cryopreservation;	2004
Ascorbate distribution during hibernation is independent of ascorbate redox state. Free radical biology & medicine, 2004, Aug-15, Volume: 37, Issue:4 Topics: Animals; Antioxidants; Ascorbate Oxidase; Ascorbic Acid; Brain; Chromatography, High Pressure Liquid	2004
H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney international, 2005, Volume: 67, Issue:3 Topics: Allantoin; Animals; Creatinine; Fatty Acids, Unsaturated; Kidney; Kidney Transplantation; Magnetic R	2005
Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia. Experimental neurology, 2005, Volume: 192, Issue:1 Topics: Animals; Antioxidants; Arachidonic Acid; Ascorbic Acid; Brain; Brain Ischemia; Dinoprostone; Disease	2005
Alterations in plasma antioxidants during reperfusion of the ischemic small intestine in rats. Research in veterinary science, 2006, Volume: 81, Issue:1 Topics: Animals; Antioxidants; Female; Intestine, Small; Ischemia; Lipid Peroxidation; Oxidative Stress; Per	2006
Preconditioning effects of peroxynitrite in the rat lung. Pharmacological research, 2006, Volume: 54, Issue:5 Topics: Animals; Benzamides; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning; Lung; Male; M	2006
Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection. Clinical science (London, England : 1979), 2008, Volume: 114, Issue:8 Topics: Aged; Antioxidants; Female; Hepatectomy; Humans; Intraoperative Period; Liver; Liver Neoplasms; Male	2008
Time course of peripheral oxidative stress as consequence of global ischaemic brain injury in rats. Cellular and molecular neurobiology, 2008, Volume: 28, Issue:3 Topics: Animals; Antioxidants; Brain Injuries; DNA Damage; Free Radicals; Lymphocytes; Male; Oxidative Stres	2008
Physiologic levels of uric acid inhibit xanthine oxidase in human plasma. Pediatric research, 1993, Volume: 34, Issue:3 Topics: Adult; Age Factors; Free Radical Scavengers; Humans; Infant, Newborn; Oxidation-Reduction; Reactive	1993
Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human. Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:1 Topics: Adult; Allopurinol; Animals; Blood Cell Count; Chromatography, High Pressure Liquid; Female; Humans;	1993
Effect of oxypurinol on renal reperfusion injury in the rat. Renal failure, 1993, Volume: 15, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Free Radical Scaven	1993
Nonprotein-bound iron in postasphyxial reperfusion injury of the newborn. Pediatrics, 1996, Volume: 98, Issue:5 Topics: Asphyxia Neonatorum; Brain Damage, Chronic; Creatinine; Humans; Infant, Newborn; Iron; Lipid Peroxid	1996
Assessment of xanthine oxidase in human lung and lung transplantation. The European respiratory journal, 1997, Volume: 10, Issue:3 Topics: Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Free Radicals; Heart-Lung T	1997
Direct induction of acute lung and myocardial dysfunction by liver ischemia and reperfusion. The Journal of trauma, 1997, Volume: 43, Issue:4 Topics: Acute Disease; Animals; Heart Diseases; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Lung Di	1997
Indices of oxidative stress in urine of patients undergoing coronary artery bypass grafting. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1997, Volume: 35, Issue:10 Topics: Aged; Aged, 80 and over; Biomarkers; Coronary Artery Bypass; Creatinine; Female; Humans; Hypoxanthin	1997
Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase. American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:5 Pt 1 Topics: Acidosis; Analysis of Variance; Animals; Blood Pressure; Capillaries; Capillary Permeability; Carbon	1998
Evaluation of serum uric acid changes in different forms of hepatic vascular inflow occlusion in human liver surgeries. Life sciences, 1999, Volume: 64, Issue:5 Topics: Adolescent; Adult; Aged; Biomarkers; Child; Female; Hepatectomy; Humans; Intraoperative Complication	1999
The beneficial effects of peroxynitrite on ischaemia-reperfusion arrhythmias in rat isolated hearts. European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Catalase; Dose-Response Relationship, Drug; H	1999
N-Hydroxyguanidine compound 1-(3,4-dimethoxy- 2-chlorobenzylideneamino)-3-hydroxyguanidine inhibits the xanthine oxidase mediated generation of superoxide radical. Archives of biochemistry and biophysics, 2000, May-01, Volume: 377, Issue:1 Topics: Allopurinol; Animals; Binding Sites; Catalysis; Cattle; Chromatography, High Pressure Liquid; Electr	2000
Ischemia/reperfusion injury of rat small intestine: the effect of allopurinol dosage. Transplantation proceedings, 2001, Volume: 33, Issue:5 Topics: Administration, Oral; Allopurinol; Analysis of Variance; Animals; Antioxidants; Free Radical Scaveng	2001
Off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2001, Volume: 20, Issue:5 Topics: Aged; Cardiopulmonary Bypass; Coronary Artery Bypass; Creatinine; Female; Humans; Hypoxanthine; Kidn	2001
Changes in the xanthine dehydrogenase/xanthine oxidase ratio in the rat kidney subjected to ischemia-reperfusion stress: preventive effect of some flavonoids. Research communications in chemical pathology and pharmacology, 1992, Volume: 78, Issue:2 Topics: Animals; Free Radical Scavengers; Ischemia; Kidney; Male; Quercetin; Rats; Rats, Wistar; Reperfusion	1992
Role of oxygen radicals in tourniquet-related ischemia-reperfusion injury of human patients. Klinische Wochenschrift, 1991, Dec-15, Volume: 69, Issue:21-23 Topics: Adult; Arm; Free Radicals; Histamine; Humans; Oxygen; Reperfusion Injury; Tourniquets; Uric Acid; Xa	1991
Effect of bile acids on ischemia-reperfusion liver injury. Journal of hepatology, 1991, Volume: 13, Issue:3 Topics: Animals; Aspartate Aminotransferases; Bile; Ischemia; Isomerism; L-Lactate Dehydrogenase; Liver Circ	1991
Hydrogen peroxide-induced alterations in prostaglandin secretion in the rat colon in vitro. Inflammation, 1990, Volume: 14, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Adrenal Cortex Hormones; Animals; Antioxidants; Calcimycin; Colon; Epi	1990
Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:2 Topics: Animals; Female; Hypoxanthine; Hypoxanthines; L-Lactate Dehydrogenase; Liver Circulation; Malondiald	1989

uric acid and Reperfusion Injury