uric acid has been researched along with Primary Peritonitis in 49 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues." | 7.73 | Gout-associated uric acid crystals activate the NALP3 inflammasome. ( Martinon, F; Mayor, A; Pétrilli, V; Tardivel, A; Tschopp, J, 2006) |
| "Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues." | 3.73 | Gout-associated uric acid crystals activate the NALP3 inflammasome. ( Martinon, F; Mayor, A; Pétrilli, V; Tardivel, A; Tschopp, J, 2006) |
| "LPS-induced septic shock and monosodium urate (MSU)-induced murine peritonitis models were employed for in vivo evaluations." | 1.56 | Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation. ( Akther, M; Han, JH; Jiang, J; Kang, TB; Kopalli, SR; Koppula, S; Lee, KH; Lian, ML; Quan, LH; Sun, X, 2020) |
| "Gout is one of the most common metabolic disorders in human." | 1.51 | Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation. ( Chen, J; Duan, L; Rao, X; Razavi, M; Tao, Y; Wei, Y; Zhong, J, 2019) |
| "Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation." | 1.51 | Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation. ( He, YL; Mi, QS; Yang, QB; Zhang, QB; Zhou, JG, 2019) |
| "Obovatol was treated to macrophages with inflammasome triggers, and secretions of interleukin (IL)-1β, IL-18, and caspase-1 were measured as readouts of inflammasome activation." | 1.51 | Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation. ( Ahn, H; Han, BC; Jung, EM; Kang, SG; Kim, J; Kim, JC; Lee, GS; Lee, J; Lee, SH; Shin, H; Yang, H, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (10.20) | 18.7374 |
| 1990's | 4 (8.16) | 18.2507 |
| 2000's | 6 (12.24) | 29.6817 |
| 2010's | 25 (51.02) | 24.3611 |
| 2020's | 9 (18.37) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, GQ | 1 |
| Chen, G | 1 |
| Yang, J | 1 |
| Qin, WY | 1 |
| Ping, J | 1 |
| Chen, J | 2 |
| Mei, A | 1 |
| Liu, X | 2 |
| Braunstein, Z | 1 |
| Wei, Y | 2 |
| Wang, B | 1 |
| Duan, L | 2 |
| Rao, X | 2 |
| Rajagopalan, S | 1 |
| Dong, L | 1 |
| Zhong, J | 3 |
| Tsujimoto, K | 3 |
| Jo, T | 3 |
| Nagira, D | 3 |
| Konaka, H | 3 |
| Park, JH | 3 |
| Yoshimura, SI | 3 |
| Ninomiya, A | 3 |
| Sugihara, F | 3 |
| Hirayama, T | 3 |
| Itotagawa, E | 3 |
| Matsuzaki, Y | 3 |
| Takaichi, Y | 3 |
| Aoki, W | 3 |
| Saita, S | 3 |
| Nakamura, S | 3 |
| Ballabio, A | 3 |
| Nada, S | 3 |
| Okada, M | 3 |
| Takamatsu, H | 3 |
| Kumanogoh, A | 3 |
| Jiang, H | 1 |
| Song, D | 1 |
| Zhou, X | 1 |
| Chen, F | 1 |
| Yu, Q | 1 |
| Ren, L | 1 |
| Dai, Q | 1 |
| Zeng, M | 1 |
| Højen, JF | 1 |
| Kristensen, MLV | 1 |
| McKee, AS | 1 |
| Wade, MT | 1 |
| Azam, T | 1 |
| Lunding, LP | 1 |
| de Graaf, DM | 2 |
| Swartzwelter, BJ | 1 |
| Wegmann, M | 1 |
| Tolstrup, M | 1 |
| Beckman, K | 1 |
| Fujita, M | 1 |
| Fischer, S | 1 |
| Dinarello, CA | 2 |
| Marinho, Y | 1 |
| Marques-da-Silva, C | 1 |
| Santana, PT | 1 |
| Chaves, MM | 1 |
| Tamura, AS | 1 |
| Rangel, TP | 1 |
| Gomes-E-Silva, IV | 1 |
| Guimarães, MZP | 1 |
| Coutinho-Silva, R | 1 |
| Powers, NE | 1 |
| Swartzwelter, B | 1 |
| Marchetti, C | 1 |
| Lerchner, A | 1 |
| Schlapschy, M | 1 |
| Datar, R | 1 |
| Binder, U | 1 |
| Edwards, CK | 1 |
| Skerra, A | 1 |
| Jiang, J | 3 |
| Sun, X | 5 |
| Akther, M | 2 |
| Lian, ML | 1 |
| Quan, LH | 1 |
| Koppula, S | 5 |
| Han, JH | 2 |
| Kopalli, SR | 1 |
| Kang, TB | 6 |
| Lee, KH | 6 |
| Zhao, Q | 1 |
| Bi, Y | 1 |
| Guo, J | 1 |
| Liu, YX | 1 |
| Pan, LR | 1 |
| Tan, Y | 1 |
| Yu, XJ | 1 |
| Wu, CH | 1 |
| Gan, CH | 1 |
| Li, LH | 1 |
| Chang, JC | 1 |
| Chen, ST | 1 |
| Menon, MP | 1 |
| Cheng, SM | 1 |
| Yang, SP | 1 |
| Ho, CL | 1 |
| Chernikov, OV | 1 |
| Lin, CH | 1 |
| Lam, Y | 1 |
| Hua, KF | 1 |
| Hsieh, YP | 1 |
| Chang, CC | 1 |
| Kor, CT | 1 |
| Yang, Y | 1 |
| Wen, YK | 1 |
| Chiu, PF | 1 |
| Lin, CC | 1 |
| Nasibov, EY | 1 |
| Heo, KH | 1 |
| Shim, DW | 3 |
| Kim, MK | 5 |
| Yu, SH | 3 |
| Kim, HB | 2 |
| Kim, TJ | 2 |
| Ji, YE | 1 |
| Li, WY | 1 |
| Lee, SW | 1 |
| Lim, H | 1 |
| Min, DS | 1 |
| Park, H | 1 |
| Kim, HP | 1 |
| Chung, YH | 1 |
| Kim, HY | 1 |
| Yoon, BR | 1 |
| Kang, YJ | 1 |
| Lee, WW | 1 |
| Razavi, M | 1 |
| Tao, Y | 1 |
| Kim, TY | 1 |
| Rashidi, M | 1 |
| Simpson, DS | 1 |
| Hempel, A | 1 |
| Frank, D | 1 |
| Petrie, E | 1 |
| Vince, A | 1 |
| Feltham, R | 1 |
| Murphy, J | 1 |
| Chatfield, SM | 1 |
| Salvesen, GS | 1 |
| Murphy, JM | 1 |
| Wicks, IP | 1 |
| Vince, JE | 1 |
| Yang, QB | 1 |
| He, YL | 1 |
| Zhang, QB | 1 |
| Mi, QS | 1 |
| Zhou, JG | 1 |
| Kim, J | 2 |
| Ahn, H | 1 |
| Han, BC | 1 |
| Shin, H | 1 |
| Kim, JC | 1 |
| Jung, EM | 1 |
| Yang, H | 2 |
| Lee, J | 1 |
| Kang, SG | 1 |
| Lee, SH | 1 |
| Lee, GS | 1 |
| Licandro, G | 1 |
| Ling Khor, H | 1 |
| Beretta, O | 1 |
| Lai, J | 1 |
| Derks, H | 1 |
| Laudisi, F | 1 |
| Conforti-Andreoni, C | 1 |
| Liang Qian, H | 1 |
| Teng, GG | 1 |
| Ricciardi-Castagnoli, P | 1 |
| Mortellaro, A | 1 |
| Kataoka, H | 1 |
| Yang, K | 1 |
| Rock, KL | 1 |
| Ives, A | 1 |
| Nomura, J | 1 |
| Martinon, F | 2 |
| Roger, T | 1 |
| LeRoy, D | 1 |
| Miner, JN | 1 |
| Simon, G | 1 |
| Busso, N | 1 |
| So, A | 2 |
| Jhang, JJ | 2 |
| Lu, CC | 2 |
| Ho, CY | 1 |
| Cheng, YT | 1 |
| Yen, GC | 2 |
| Oh, NH | 1 |
| Han, JW | 2 |
| Sim, EJ | 1 |
| Kwak, SB | 1 |
| Kim, YK | 1 |
| Park, PJ | 1 |
| Shin, WY | 1 |
| Shim, EJ | 1 |
| Nurmi, K | 1 |
| Kareinen, I | 1 |
| Virkanen, J | 1 |
| Rajamäki, K | 1 |
| Kouri, VP | 1 |
| Vaali, K | 1 |
| Levonen, AL | 1 |
| Fyhrquist, N | 1 |
| Matikainen, S | 1 |
| Kovanen, PT | 1 |
| Eklund, KK | 1 |
| Chung, IC | 1 |
| OuYang, CN | 1 |
| Yuan, SN | 1 |
| Li, HP | 1 |
| Chen, JT | 1 |
| Shieh, HR | 1 |
| Chen, YJ | 1 |
| Ojcius, DM | 1 |
| Chu, CL | 1 |
| Yu, JS | 1 |
| Chang, YS | 1 |
| Chen, LC | 1 |
| Hu, Y | 1 |
| Mao, K | 1 |
| Zeng, Y | 1 |
| Chen, S | 1 |
| Tao, Z | 1 |
| Yang, C | 1 |
| Sun, S | 1 |
| Wu, X | 1 |
| Meng, G | 1 |
| Sun, B | 1 |
| Martin, WJ | 1 |
| Shaw, O | 1 |
| Steiger, S | 1 |
| Harper, JL | 1 |
| Uratsuji, H | 1 |
| Tada, Y | 1 |
| Kawashima, T | 1 |
| Kamata, M | 1 |
| Hau, CS | 1 |
| Asano, Y | 1 |
| Sugaya, M | 1 |
| Kadono, T | 1 |
| Asahina, A | 1 |
| Sato, S | 1 |
| Tamaki, K | 1 |
| Lu, B | 1 |
| Nakamura, T | 1 |
| Inouye, K | 1 |
| Li, J | 1 |
| Tang, Y | 1 |
| Lundbäck, P | 1 |
| Valdes-Ferrer, SI | 1 |
| Olofsson, PS | 1 |
| Kalb, T | 1 |
| Roth, J | 1 |
| Zou, Y | 1 |
| Erlandsson-Harris, H | 1 |
| Ting, JP | 1 |
| Wang, H | 1 |
| Andersson, U | 1 |
| Antoine, DJ | 1 |
| Chavan, SS | 1 |
| Hotamisligil, GS | 1 |
| Tracey, KJ | 1 |
| Getting, SJ | 4 |
| Christian, HC | 1 |
| Lam, CW | 2 |
| Gavins, FN | 1 |
| Flower, RJ | 2 |
| Schiöth, HB | 1 |
| Perretti, M | 3 |
| Di Filippo, C | 2 |
| Rossi, F | 1 |
| D'Amico, M | 2 |
| Pétrilli, V | 1 |
| Mayor, A | 1 |
| Tardivel, A | 1 |
| Tschopp, J | 2 |
| Rose, DM | 1 |
| Sydlaske, AD | 1 |
| Agha-Babakhani, A | 1 |
| Johnson, K | 1 |
| Terkeltaub, R | 1 |
| De Smedt, T | 1 |
| Revaz, S | 1 |
| Madden, MA | 1 |
| Zimmerman, SW | 1 |
| Simpson, DP | 1 |
| Hart, PH | 1 |
| Jones, CA | 1 |
| Finlay-Jones, JJ | 1 |
| Douma, CE | 1 |
| de Waart, DR | 1 |
| Zemel, D | 1 |
| Imholz, AL | 1 |
| Koomen, GC | 1 |
| Struijk, DG | 1 |
| Krediet, RT | 1 |
| Parente, L | 1 |
| de Medicis, R | 1 |
| Lussier, A | 1 |
| Woliztky, BA | 1 |
| Martins, MA | 1 |
| Margalit, A | 1 |
| Hauser, SD | 1 |
| Isakson, PC | 1 |
| Griswold, DE | 1 |
| Hillegass, L | 1 |
| Rotilio, D | 1 |
| Mong, S | 1 |
| Hanna, N | 1 |
| Rubin, J | 1 |
| Adair, C | 1 |
| Huarte-Loza, E | 1 |
| Selgas, R | 1 |
| Carmona, AR | 1 |
| Martinez, ME | 1 |
| Muñoz, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia[NCT04420260] | 152 participants (Actual) | Interventional | 2021-03-18 | Completed | |||
| The Role of Gut Microbiota in the Pathogenesis of Ankylosing Spondylitis (AS), and the Effect of Fecal Microbiota Transplantation on Gut Microbiota, Gut Wall Inflammation and Clinical Activity of AS[NCT03726645] | Early Phase 1 | 20 participants (Actual) | Interventional | 2018-10-24 | Enrolling by invitation | ||
| Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC): A Phase II Clinical Study[NCT01984892] | Phase 2 | 8 participants (Actual) | Interventional | 2013-11-30 | Terminated (stopped due to PI discretion, low enrollment) | ||
| Effect of Low Dose of Colchicine on Platelet Reactivty in Patients With Chronic Coronary Disease[NCT05956145] | Phase 3 | 80 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patients who are alive on the date of closing follow-up, or 30 months after completing all study treatments, will be censored on that date (NCT01984892)
Timeframe: up to 30 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Participants With Stage 4 Cancer | 8 |
"Progression-free survival defined as the time in weeks from study entry until tumor progression defined using the Wolchok criteria or death. Patients who are alive and free from progression on the date of closing follow-up will be censored on that date.~In order to minimize the potential for misdiagnosis of pseudoprogression, related to early inflammation, tumor measurement for determination of progression will be made at the earliest at 26 weeks." (NCT01984892)
Timeframe: average 52 weeks
| Intervention | weeks (Number) |
|---|---|
| Participants With Stage 4 Cancer | 41 |
1 trial available for uric acid and Primary Peritonitis
| Article | Year |
|---|---|
A pilot study of IL-1 inhibition by anakinra in acute gout.
Topics: Adult; Aged; Animals; Arthritis, Gouty; Chemotaxis, Leukocyte; Female; Humans; Interleukin 1 Recepto | 2007 |
48 other studies available for uric acid and Primary Peritonitis
| Article | Year |
|---|---|
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Topics: Animals; Caspase 1; Disease Models, Animal; Drugs, Chinese Herbal; Gout; Inflammasomes; Inflammation | 2022 |
Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation.
Topics: Animals; Cell Movement; Disease Models, Animal; Gene Expression Regulation; Glucagon-Like Peptide-1 | 2022 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression.
Topics: Animals; Inflammation; Kelch-Like ECH-Associated Protein 1; Mice; NF-E2-Related Factor 2; Peritoniti | 2023 |
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
Topics: A549 Cells; Animals; Antibodies, Blocking; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, | 2019 |
MSU Crystals induce sterile IL-1β secretion via P2X7 receptor activation and HMGB1 release.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Edema; HMGB1 Protein; Humans; Inflammation; | 2020 |
PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis.
Topics: Animals; Biomarkers; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; | 2020 |
Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents; Ginsenosides; Inflammasomes; Interleukin-1beta; Lipopolysaccharid | 2020 |
Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Inflammasomes; Inflammation; Lipopolysaccharides | 2021 |
A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Autophagy-Related Proteins; Cytokines; Disease Models, | 2020 |
Relationship between uric acid and technique failure in patients on continuous ambulatory peritoneal dialysis: a long-term observational cohort study.
Topics: Adult; Aged; Cohort Studies; Female; Humans; Hyperuricemia; Kidney Failure, Chronic; Longitudinal St | 2017 |
[[Efficacy of abdominal sanation, using superoxyodysmutase in the treatment of peritonitis for restoration of the kioneys functional activity].]
Topics: Abdominal Cavity; Anti-Infective Agents, Local; Bilirubin; C-Reactive Protein; Case-Control Studies; | 2016 |
Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination.
Topics: Actinidia; Animals; Anti-Inflammatory Agents; Caspase 1; Cells, Cultured; Female; Inflammasomes; Int | 2018 |
Eucalyptus globulus Inhibits Inflammasome-Activated Pro-Inflammatory Responses and Ameliorate Monosodium Urate-Induced Peritonitis in Murine Experimental Model.
Topics: Animals; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cultured; Disease Models, Animal; Eucaly | 2018 |
Flavonoids interfere with NLRP3 inflammasome activation.
Topics: Animals; Caspase 1; Cell Line; Flavonoids; Focal Adhesion Kinase 2; Humans; Inflammasomes; Inflammat | 2018 |
Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes.
Topics: Animals; Cells, Cultured; Cytokines; Female; Humans; Mice, Inbred C57BL; Monocytes; p38 Mitogen-Acti | 2019 |
Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation.
Topics: Animals; Disease Models, Animal; Gout; Inflammation; Interleukin-1beta; Macrophages; Male; Mice; Mic | 2019 |
Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation.
Topics: Animals; Anti-Inflammatory Agents; CARD Signaling Adaptor Proteins; Chrysanthemum; DNA-Binding Prote | 2019 |
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release.
Topics: Acrylamides; Animals; Caspase 1; Cathepsins; Female; Gout; Interleukin-1beta; Intracellular Signalin | 2019 |
Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation.
Topics: Adult; Animals; Body Fluids; Cytokines; Disease Models, Animal; Down-Regulation; Edema; Female; Foot | 2019 |
Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Caspase 1; Cytokines; Disease | 2019 |
The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.
Topics: Animals; Antioxidants; Apoptosis; Carrier Proteins; Caspase 1; Cell Survival; Cells, Cultured; Dendr | 2013 |
The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury | 2015 |
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.
Topics: Animals; Autophagy; Blotting, Western; Calcium; Calcium Phosphates; Carrier Proteins; Caspase 1; Gen | 2015 |
Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation.
Topics: Animals; Calcium; Carrier Proteins; Catechin; Disease Models, Animal; Free Radical Scavengers; Galli | 2015 |
Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-β signaling and NLRP3 inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents; Carrier Proteins; Cell Line; Cells, Cultured; Female; Inflammasom | 2015 |
Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice.
Topics: Animals; Catechin; Cell Line; Chemokine CCL2; Humans; Interleukin-1beta; Interleukin-6; Male; Mice, | 2016 |
Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Apoptosis Regulatory Prote | 2016 |
Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation.
Topics: Animals; Cell Line; Hemin; Humans; Immunomodulation; Inflammasomes; Interleukin-1beta; Macrophages; | 2017 |
Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Topics: Animals; CARD Signaling Adaptor Proteins; Focal Adhesion Kinase 2; Inflammasomes; Inflammation; Mice | 2016 |
Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Antioxidants; Carrier Proteins; Caspase 1; H | 2010 |
Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout.
Topics: Animals; Blotting, Western; Cell Differentiation; Disease Models, Animal; Flow Cytometry; Gout; Infl | 2011 |
P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals.
Topics: Animals; Antioxidants; Cell Line; Cytokines; Disease Models, Animal; Gout; Humans; Hyperuricemia; In | 2012 |
Novel role of PKR in inflammasome activation and HMGB1 release.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Animals; Antigens, Bacterial; Apoptosi | 2012 |
Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cells, Cultured; Crystallization; C | 2003 |
Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis.
Topics: Animals; Azepines; Chemokines; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Interleukin-1 | 2004 |
Gout-associated uric acid crystals activate the NALP3 inflammasome.
Topics: Animals; Calcium Pyrophosphate; Carrier Proteins; Caspase 1; Cell Line; Cells, Cultured; Chondrocalc | 2006 |
The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage.
Topics: Acute Disease; alpha-MSH; Animals; Anti-Inflammatory Agents; Blood Pressure; Carrageenan; Chemokine | 2006 |
Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils.
Topics: Animals; Apoptosis; Cells, Cultured; Female; Gene Expression Regulation; Gout; GTP-Binding Proteins; | 2006 |
Longitudinal comparison of intermittent versus continuous ambulatory peritoneal dialysis, in the same patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Calcium; Carbon Dioxide; | 1981 |
Inflammatory fluids regulate TNF-alpha, but not IL-1 beta, production by human peritoneal macrophages. A study of patients on continuous ambulatory peritoneal dialysis with peritonitis.
Topics: Acute-Phase Proteins; Adrenal Cortex; Anti-Bacterial Agents; Blood Bactericidal Activity; Creatinine | 1993 |
Nitrate in stable CAPD patients and during peritonitis.
Topics: Acute Disease; Adult; Aged; Biological Transport; Creatinine; Dialysis Solutions; Female; Humans; Ma | 1995 |
Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins.
Topics: Animals; Cell Movement; Crystallization; Endothelium, Vascular; Gout; Histamine; Macrophage-1 Antige | 1997 |
Regulation of in vivo prostaglandin biosynthesis by glutathione.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Fatty Acids, Unsaturated; Glutathione; Glyceraldehyde-3 | 1999 |
Absence of a lyso-PAF relationship with PAF (platelet activating factor) in monosodium urate crystal-induced inflammatory exudates.
Topics: Animals; Ascitic Fluid; Capillary Permeability; Male; Mice; Mice, Inbred BALB C; Peritonitis; Platel | 1989 |
Nitrogen losses and cephalothin absorption in peritonitis treated by hourly peritoneal dialysis.
Topics: Absorption; Adult; Aged; Albumins; Cephalothin; Creatinine; Female; Humans; Male; Middle Aged; Nitro | 1988 |
Peritoneal membrane failure as a determinant of the CAPD future. An epidemiological, functional and pathological study.
Topics: Creatinine; Female; Humans; Kinetics; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; | 1987 |
Bile peritonitis. Diagnosis and course.
Topics: Adult; Aged; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile; Bilirubin; Blood Gluc | 1968 |