Page last updated: 2024-10-20

uric acid and Pre-Hypertension

uric acid has been researched along with Pre-Hypertension in 33 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
"Studies examining the association between levels of serum uric acid (SUA) and risk of prehypertension still remained controversial conclusions."9.22Serum uric acid and risk of prehypertension: a dose-response meta-analysis of 17 observational studies of approximately 79 thousand participants. ( Han, M; Hong, F; Li, Q; Liu, L; Qie, R; Zhan, S; Zhang, C; Zhang, J; Zhang, L; Zhang, X, 2022)
" To date, there are no studies in adults that have evaluated the impact of low fructose diets and allopurinol on prehypertensive and overweight subjects."9.20A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial. ( Jalal, D; Johnson, RJ; Madero, M; Rodríguez Castellanos, FE; Salazar, J; Sanchez-Lozada, LG; Vazquez-Rangel, A; Villalobos-Martín, M, 2015)
"Evidence is lacking about the role of serum uric acid (SUA) in the progression from prehypertension to hypertension."8.12Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study. ( Chen, S; Luo, Y; Mo, D; Tian, X; Wang, A; Wu, S; Zhang, L; Zuo, Y, 2022)
"To observe the changes in blood pressure (BP) over 10 years and to investigate current BP association to serum uric acid (SUA) levels and cardiovascular risk factors in the epidemiological data of a target group of patients with prehypertension in 2007."7.96Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study. ( Bawazier, LA; Irijanto, F; Kholiq, A; Sja'bani, M; Tomino, Y; Widiatmoko, A; Zulaela, Z, 2020)
"Hyperuricemia is a recognized risk factor for cardiovascular diseases."6.80Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension. ( Chen, YM; Ho, CS; Liu, ZM; Woo, J, 2015)
"Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg."6.55Serum uric acid levels and risk of prehypertension: a meta-analysis. ( Fan, Y; Gong, D; Jiang, M, 2017)
"Studies examining the association between levels of serum uric acid (SUA) and risk of prehypertension still remained controversial conclusions."5.22Serum uric acid and risk of prehypertension: a dose-response meta-analysis of 17 observational studies of approximately 79 thousand participants. ( Han, M; Hong, F; Li, Q; Liu, L; Qie, R; Zhan, S; Zhang, C; Zhang, J; Zhang, L; Zhang, X, 2022)
" To date, there are no studies in adults that have evaluated the impact of low fructose diets and allopurinol on prehypertensive and overweight subjects."5.20A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial. ( Jalal, D; Johnson, RJ; Madero, M; Rodríguez Castellanos, FE; Salazar, J; Sanchez-Lozada, LG; Vazquez-Rangel, A; Villalobos-Martín, M, 2015)
"Evidence is lacking about the role of serum uric acid (SUA) in the progression from prehypertension to hypertension."4.12Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study. ( Chen, S; Luo, Y; Mo, D; Tian, X; Wang, A; Wu, S; Zhang, L; Zuo, Y, 2022)
"To observe the changes in blood pressure (BP) over 10 years and to investigate current BP association to serum uric acid (SUA) levels and cardiovascular risk factors in the epidemiological data of a target group of patients with prehypertension in 2007."3.96Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study. ( Bawazier, LA; Irijanto, F; Kholiq, A; Sja'bani, M; Tomino, Y; Widiatmoko, A; Zulaela, Z, 2020)
"Hyperuricemia is a recognized risk factor for cardiovascular diseases."2.80Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension. ( Chen, YM; Ho, CS; Liu, ZM; Woo, J, 2015)
"Prehypertension is a risk factor for the development of hypertension and other cardiovascular diseases."1.46Subclinical target organ damage in normotensive and prehypertensive patients. ( Chen, YH; Yi, H; Zhang, H; Zhang, WZ; Zhou, MC, 2017)
"Prehypertension was defined as a systolic blood pressure of 120-139 mmHg and/or diastolic blood pressure of 80-89 mmHg, and prediabetes was defined as a fasting blood glucose of 5."1.37High prevalence of coexisting prehypertension and prediabetes among healthy adults in northern and northeastern China. ( Chen, XQ; Ding, HT; Guo, XZ; Han, SM; Liu, YH; Qin, XZ; Qiu, L; Wu, J; Wu, W; Xia, LY; Xu, CL; Yan, WH; Zhu, GJ, 2011)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's26 (78.79)24.3611
2020's7 (21.21)2.80

Authors

AuthorsStudies
Alatas, H1
Sja'bani, M2
Mustofa, M1
Mukti, AG1
Bawazier, LA2
Irijanto, F2
Zulaela, Z2
Tomino, Y2
Obrycki, Ł1
Feber, J1
Derezinski, T1
Lewandowska, W1
Kułaga, Z1
Litwin, M1
Lee, S1
Choi, KB1
Kim, SJ1
Widiatmoko, A1
Kholiq, A1
Liu, L2
Zhang, X2
Li, Q1
Qie, R1
Han, M1
Zhan, S1
Zhang, J1
Zhang, L2
Zhang, C1
Hong, F1
Tian, X1
Wang, A1
Zuo, Y1
Chen, S1
Mo, D2
Wu, S1
Luo, Y1
Zhu, L1
Fang, Z1
Jin, Y1
Chang, W1
Chen, Y1
Yao, Y1
Thitiwuthikiat, P1
Siriwittayawan, D1
Nuamchit, T1
Kuwabara, M1
Hisatome, I1
Niwa, K1
Hara, S1
Roncal-Jimenez, CA1
Bjornstad, P1
Nakagawa, T1
Andres-Hernando, A1
Sato, Y1
Jensen, T1
Garcia, G1
Rodriguez-Iturbe, B1
Ohno, M1
Lanaspa, MA1
Johnson, RJ2
Zidek, W1
Wang, Y2
Hu, JW2
Qu, PF1
Wang, KK2
Yan, Y1
Chu, C2
Zheng, WL2
Xu, XJ1
Lv, YB2
Ma, Q1
Gao, K1
Yuan, Y1
Li, H1
Yuan, ZY2
Mu, JJ2
Rizzo, M1
Obradovic, M1
Labudovic-Borovic, M1
Nikolic, D1
Montalto, G1
Rizvi, AA1
Mikhailidis, DP1
Isenovic, ER1
Bao, X2
Wang, Q2
Chen, G1
Liang, R1
Zhang, S1
Kawamoto, R1
Tabara, Y1
Kohara, K1
Kusunoki, T1
Abe, M1
Miki, T1
Liu, ZM1
Ho, CS1
Chen, YM1
Woo, J1
Jiang, L1
Yang, R1
Ye, Q1
Wu, J2
Yu, G1
Xu, J1
Pan, S1
Lotufo, PA1
Baena, CP1
Santos, IS1
Bensenor, IM1
Madero, M1
Rodríguez Castellanos, FE1
Jalal, D1
Villalobos-Martín, M1
Salazar, J1
Vazquez-Rangel, A1
Sanchez-Lozada, LG1
Yi, H1
Zhang, WZ1
Zhang, H1
Chen, YH1
Zhou, MC1
Fu, QY1
Ma, L1
Li, CC1
He, FG1
He, ZJ1
Zhang, WS1
Zhang, ZH1
Wu, IH1
Wu, JS1
Sun, ZJ1
Lu, FH1
Chang, CS1
Chang, CJ1
Yang, YC1
Sidoti, A1
Nigrelli, S1
Rosati, A1
Bigazzi, R1
Caprioli, R1
Fanelli, R1
Acconcia, P1
Borracelli, D1
Biagioli, M1
Angelini, D1
Parrini, M1
Tonelli, L1
Tosi, P1
Manzoni, D1
Jiang, M1
Gong, D1
Fan, Y1
Gu, Y1
Li, C1
Zhang, Q2
Meng, G1
Wu, H1
Du, H1
Shi, H1
Xia, Y1
Guo, X1
Liu, X1
Su, Q1
Fang, L1
Yu, F1
Yang, H1
Yu, B1
Sun, S1
Wang, X1
Zhou, M1
Jia, Q1
Guo, Q1
Song, K1
Huang, G1
Wang, G1
Niu, K1
Juraschek, SP1
Gelber, AC1
Choi, HK1
Appel, LJ1
Miller, ER1
Cao, YM1
Hirschler, V1
González, C1
Maccallini, G1
Molinari, C1
Castano, L1
Teng, F1
Liang, J1
Zou, CY1
Qi, L1
Song, HD1
Nery, AB1
Mesquita, ET1
Lugon, JR1
Kang, HC1
de Miranda, VA1
de Souza, BG1
Andrade, JA1
Rosa, ML1
Yan, WH1
Qiu, L1
Chen, XQ1
Guo, XZ1
Wu, W1
Xia, LY1
Qin, XZ1
Liu, YH1
Ding, HT1
Han, SM1
Xu, CL1
Zhu, GJ1
Peng, H1
Ding, J1
Peng, Y1
Xu, Y1
Chao, X1
Tian, H1
Zhang, Y1
Whelton, A1
Soletsky, B1
Feig, DI1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-blind Randomized Controlled Trial on Whole Soy and Daidzein Supplementation on Reduction of Blood Pressure in Prehypertensive Postmenopausal Chinese Women[NCT01270737]270 participants (Anticipated)Interventional2011-03-31Not yet recruiting
The Effects of Soy Protein and/or Isoflavones on Glycemic Control, Insulin Sensitivity and Cardiovascular Risk Factors-a Six Months RCT Among Postmenopausal Women[NCT00856882]0 participants Interventional2007-10-31Completed
[NCT00000608]Phase 20 participants Interventional1997-02-28Completed
[NCT00288158]Phase 260 participants (Actual)Interventional2008-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for uric acid and Pre-Hypertension

ArticleYear
Serum uric acid and risk of prehypertension: a dose-response meta-analysis of 17 observational studies of approximately 79 thousand participants.
    Acta cardiologica, 2022, Volume: 77, Issue:2

    Topics: Humans; Hypertension; Medical History Taking; Observational Studies as Topic; Prehypertension; Risk

2022
    MMW Fortschritte der Medizin, 2018, Volume: 160, Issue:5

    Topics: Cohort Studies; Humans; Hypertension; Hyperuricemia; Japan; Prehypertension; Uric Acid

2018
Uric acid metabolism in pre-hypertension and the metabolic syndrome.
    Current vascular pharmacology, 2014, Volume: 12, Issue:4

    Topics: Animals; Glucose Transport Proteins, Facilitative; Humans; Hyperuricemia; Metabolic Syndrome; Organi

2014
Serum uric acid levels and risk of prehypertension: a meta-analysis.
    Clinical chemistry and laboratory medicine, 2017, Mar-01, Volume: 55, Issue:3

    Topics: Biomarkers; Female; Humans; Male; Prehypertension; Risk Factors; Uric Acid

2017
The Role of Uric Acid in Hypertension of Adolescents, Prehypertension and Salt Sensitivity of Blood Pressure.
    Medical science monitor : international medical journal of experimental and clinical research, 2017, Feb-13, Volume: 23

    Topics: Adolescent; Age Factors; Blood Pressure; Essential Hypertension; Humans; Hypertension; Hyperuricemia

2017

Trials

5 trials available for uric acid and Pre-Hypertension

ArticleYear
The effects of soursop supplementation on blood pressure, serum uric acid, and kidney function in a prehypertensive population in accordance with the 2017 ACC/AHA guideline.
    Journal of human hypertension, 2020, Volume: 34, Issue:3

    Topics: Annona; Blood Pressure; Dietary Supplements; Humans; Hypertension; Kidney; Prehypertension; Risk Fac

2020
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial.
    Journal of the American Society of Hypertension : JASH, 2015, Volume: 9, Issue:11

    Topics: Adult; Allopurinol; Blood Glucose; Blood Pressure Determination; Blood Pressure Monitoring, Ambulato

2015
Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:12

    Topics: Adult; Black or African American; Cross-Over Studies; Female; Humans; Hypertension; Hyperuricemia; M

2016
Uric acid reduction rectifies prehypertension in obese adolescents.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:5

    Topics: Adolescent; Allopurinol; Blood Pressure; Child; Double-Blind Method; Drug Administration Schedule; F

2012

Other Studies

23 other studies available for uric acid and Pre-Hypertension

ArticleYear
Hemodynamic Patterns and Target Organ Damage in Adolescents With Ambulatory Prehypertension.
    Hypertension (Dallas, Tex. : 1979), 2020, Volume: 75, Issue:3

    Topics: Adolescent; Blood Pressure Monitoring, Ambulatory; Carotid Intima-Media Thickness; Female; Heart Ven

2020
The effect of uric acid and urinary sodium excretion on prehypertension: a nationwide population-based study.
    BMC cardiovascular disorders, 2020, 05-27, Volume: 20, Issue:1

    Topics: Adult; Biomarkers; Blood Pressure; Female; Humans; Male; Middle Aged; Natriuresis; Nutrition Surveys

2020
Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study.
    BMJ open, 2020, 09-09, Volume: 10, Issue:9

    Topics: Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; Female; Heart Disease Risk Factors

2020
Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study.
    Journal of human hypertension, 2022, Volume: 36, Issue:4

    Topics: Humans; Hypertension; Prehypertension; Prospective Studies; Risk Factors; Uric Acid

2022
Association between Serum Uric Acid and Pre-hypertension and Hypertension among Chinese Adults.
    Arquivos brasileiros de cardiologia, 2021, Volume: 116, Issue:6

    Topics: Adult; China; Cross-Sectional Studies; Female; Humans; Hypertension; Prehypertension; Risk Factors;

2021
Prehypertension and high serum uric acid increase risk of arterial stiffness.
    Scandinavian journal of clinical and laboratory investigation, 2017, Volume: 77, Issue:8

    Topics: Adult; Biomarkers; Female; Humans; Male; Middle Aged; Prehypertension; Risk Factors; Uric Acid; Vasc

2017
Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.
    Hypertension (Dallas, Tex. : 1979), 2018, Volume: 71, Issue:1

    Topics: Adult; Age Factors; Aged; Blood Pressure; Body Mass Index; Cohort Studies; Disease Progression; Fema

2018
Association between urinary sodium excretion and uric acid, and its interaction on the risk of prehypertension among Chinese young adults.
    Scientific reports, 2018, 05-17, Volume: 8, Issue:1

    Topics: Adult; Blood Pressure; China; Cohort Studies; Female; Humans; Male; Middle Aged; Prehypertension; Pr

2018
Serum concentration of uric acid associated with prehypertension among Chinese population.
    Angiology, 2014, Volume: 65, Issue:9

    Topics: Adult; Biomarkers; China; Cross-Sectional Studies; Female; Health Surveys; Humans; Hyperuricemia; Li

2014
Interaction between serum uric acid and triglycerides in relation to prehypertension in community-dwelling Japanese adults.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2014, Volume: 36, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Asian People; Blood Glucose; Blood Pressure; Body Mass Index; Cardio

2014
Joint effects of serum uric acid and body mass index on risk of prehypertension in Chinese population.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Jun-15, Volume: 446

    Topics: Adult; Aged; Asian People; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Section

2015
Serum Uric Acid and Prehypertension Among Adults Free of Cardiovascular Diseases and Diabetes: Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
    Angiology, 2016, Volume: 67, Issue:2

    Topics: Adult; Age Factors; Aged; Biomarkers; Blood Pressure; Brazil; Comorbidity; Female; Health Surveys; H

2016
Subclinical target organ damage in normotensive and prehypertensive patients.
    Minerva cardioangiologica, 2017, Volume: 65, Issue:1

    Topics: Albuminuria; Blood Pressure; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Natriuretic

2017
Clinical Characteristics and Renal Histology in Pediatric Patients with Hypertension and Prehypertension Secondary to IgA Nephropathy.
    Nephron, 2016, Volume: 132, Issue:3

    Topics: Adolescent; Age Factors; Blood Pressure; Child; Child, Preschool; Female; Glomerular Filtration Rate

2016
Higher serum uric acid level increases risk of prehypertension in subjects with normal glucose tolerance, but not pre-diabetes and diabetes.
    Journal of human hypertension, 2016, Volume: 30, Issue:8

    Topics: Adult; Biomarkers; Blood Glucose; Blood Pressure; Cross-Sectional Studies; Diabetes Mellitus; Female

2016
Body mass index, fat free mass, uric acid, and renal function as blood pressure levels determinants in young adults.
    Nephrology (Carlton, Vic.), 2017, Volume: 22, Issue:4

    Topics: Adolescent; Age Factors; Alcohol Drinking; Biomarkers; Blood Pressure; Body Composition; Body Mass I

2017
Serum uric acid is an independent predictor for developing prehypertension: a population-based prospective cohort study.
    Journal of human hypertension, 2017, Volume: 31, Issue:2

    Topics: Adult; Biomarkers; Female; Humans; Male; Prehypertension; Prospective Studies; Uric Acid

2017
Association between blood pressure and magnesium and uric acid levels in indigenous Argentinean children at high altitude.
    American journal of human biology : the official journal of the Human Biology Council, 2017, Jul-08, Volume: 29, Issue:4

    Topics: Adolescent; Altitude; Argentina; Blood Pressure; Child; Cross-Sectional Studies; Female; Humans; Hyp

2017
[Serum uric acid and prehypertension among Chinese adults].
    Zhonghua nei ke za zhi, 2010, Volume: 49, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Blood Glucose; Blood Pressure; Body Mass I

2010
Prehypertension and cardiovascular risk factors in adults enrolled in a primary care programme.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2011, Volume: 18, Issue:2

    Topics: Adult; Alcohol Drinking; Biomarkers; Body Mass Index; Brazil; Cardiovascular Diseases; Cross-Section

2011
High prevalence of coexisting prehypertension and prediabetes among healthy adults in northern and northeastern China.
    BMC public health, 2011, Oct-12, Volume: 11

    Topics: Adolescent; Adult; Anthropometry; Blood Glucose; Blood Pressure; Cardiovascular Diseases; China; Cho

2011
Hyperuricemia and microalbuminuria are separately and independently associated with prehypertension among Chinese Han women.
    Metabolic syndrome and related disorders, 2012, Volume: 10, Issue:3

    Topics: Adult; Aged; Albuminuria; Antihypertensive Agents; Asian People; Biomarkers; Blood Pressure; Chi-Squ

2012
Hyperuricemia and hypertension: a confluence of concepts.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:5

    Topics: Blood Pressure; Female; Humans; Male; Obesity; Prehypertension; Uric Acid

2012