uric acid has been researched along with Parkinsonian Disorders in 7 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Purine levels were measured in the cellular extract and conditioned medium using high-performance liquid chromatography (HPLC) method." | 1.40 | Protection by inosine in a cellular model of Parkinson's disease. ( Bakshi, R; Cipriani, S; Schwarzschild, MA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Duan, WJ | 1 |
| Liang, L | 1 |
| Pan, MH | 1 |
| Lu, DH | 1 |
| Wang, TM | 1 |
| Li, SB | 1 |
| Zhong, HB | 1 |
| Yang, XJ | 1 |
| Cheng, Y | 1 |
| Liu, B | 1 |
| Li, WX | 1 |
| Kurihara, H | 1 |
| Bi, W | 1 |
| Li, YF | 1 |
| He, RR | 1 |
| Bao, LH | 1 |
| Zhang, YN | 1 |
| Zhang, JN | 1 |
| Gu, L | 1 |
| Yang, HM | 1 |
| Huang, YY | 1 |
| Xia, N | 1 |
| Zhang, H | 1 |
| Cipriani, S | 3 |
| Bakshi, R | 1 |
| Schwarzschild, MA | 3 |
| Tabunoki, H | 1 |
| Bono, H | 1 |
| Ito, K | 1 |
| Yokoyama, T | 1 |
| Desjardins, CA | 2 |
| Burdett, TC | 2 |
| Xu, Y | 2 |
| Xu, K | 1 |
| Gong, L | 1 |
| Zhang, QL | 1 |
| Zhang, N | 1 |
| Hua, WY | 1 |
| Huang, YX | 1 |
| Di, PW | 1 |
| Huang, T | 1 |
| Xu, XS | 1 |
| Liu, CF | 1 |
| Hu, LF | 1 |
| Luo, WF | 1 |
| Chen, X | 1 |
| Logan, R | 1 |
1 review available for uric acid and Parkinsonian Disorders
| Article | Year |
|---|---|
Can the silkworm (Bombyx mori) be used as a human disease model?
Topics: Animals; Antiparkinson Agents; Bombyx; Disease Models, Animal; Drug Discovery; Gene Expression Profi | 2016 |
6 other studies available for uric acid and Parkinsonian Disorders
| Article | Year |
|---|---|
Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation.
Topics: Animals; Apoptosis; Behavior, Animal; Camellia; Dopaminergic Neurons; Embryo, Nonmammalian; Humans; | 2020 |
Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease.
Topics: Animals; Antioxidants; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relati | 2018 |
Protection by inosine in a cellular model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Astrocytes; Cell Line; Cell Survival; Cells, Cultured; Coculture Tech | 2014 |
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Dopaminergic Neurons; Mesencephalon; Mice; Mice, I | 2012 |
Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson's disease: linking to Akt/GSK3β signaling pathway.
Topics: Animals; Blotting, Western; Brain; Dopaminergic Neurons; Glycogen Synthase Kinase 3; Glycogen Syntha | 2012 |
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration.
Topics: Allantoin; Analysis of Variance; Animals; Blotting, Western; Brain; Dopamine; Dopaminergic Neurons; | 2013 |