uric acid has been researched along with Neurodegenerative Diseases in 11 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The uric acid level was lower in the essential tremor group than in healthy subjects, but the difference did not reach statistical significance." | 7.88 | Uric acid level may not be reduced in essential tremor. ( Hong, JY; Kang, SY; Lee, CY; Park, JH; Sunwoo, MK; Yoon, JH, 2018) |
| "Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs." | 6.82 | Inosine in Neurodegenerative Diseases: From the Bench to the Bedside. ( Basile, MS; Bramanti, P; Mazzon, E, 2022) |
| "High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e." | 4.91 | The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015) |
| " The uric acid level was lower in the essential tremor group than in healthy subjects, but the difference did not reach statistical significance." | 3.88 | Uric acid level may not be reduced in essential tremor. ( Hong, JY; Kang, SY; Lee, CY; Park, JH; Sunwoo, MK; Yoon, JH, 2018) |
| "Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs." | 2.82 | Inosine in Neurodegenerative Diseases: From the Bench to the Bedside. ( Basile, MS; Bramanti, P; Mazzon, E, 2022) |
| "Uric acid (UA) is an endogenous antioxidant, low levels of which are also implicated in neurodegenerative disease." | 1.91 | The Influence of Agricultural Work and Plasma Uric Acid on Hospital Admission for Alzheimer's Disease. ( Liu, H; Reynolds, GP; Wei, X, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Losada-Barreiro, S | 1 |
| Bravo-Díaz, C | 1 |
| Basile, MS | 1 |
| Bramanti, P | 1 |
| Mazzon, E | 1 |
| Şanlı, BA | 1 |
| Whittaker, KJ | 1 |
| Motsi, GK | 1 |
| Shen, E | 1 |
| Julian, TH | 1 |
| Cooper-Knock, J | 1 |
| Liu, H | 1 |
| Reynolds, GP | 1 |
| Wei, X | 1 |
| Lee, CY | 1 |
| Yoon, JH | 1 |
| Park, JH | 1 |
| Hong, JY | 1 |
| Sunwoo, MK | 1 |
| Kang, SY | 1 |
| Zhang, C | 1 |
| Yang, Y | 1 |
| Liang, W | 1 |
| Wang, T | 1 |
| Wang, S | 1 |
| Wang, X | 1 |
| Wang, Y | 1 |
| Jiang, H | 1 |
| Feng, H | 1 |
| Cutler, RG | 1 |
| Camandola, S | 1 |
| Malott, KF | 1 |
| Edelhauser, MA | 1 |
| Mattson, MP | 1 |
| Paganoni, S | 1 |
| Schwarzschild, MA | 1 |
| Constantinescu, R | 1 |
| Andreasson, U | 1 |
| Holmberg, B | 1 |
| Zetterberg, H | 1 |
| Farstad, M | 1 |
| Haug, JO | 1 |
| Lindbak, H | 1 |
| Skaug, OE | 1 |
| Arlt, S | 1 |
| Finckh, B | 1 |
| Beisiegel, U | 1 |
| Kontush, A | 1 |
4 reviews available for uric acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases.
Topics: Animals; Free Radicals; Humans; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; P | 2017 |
Inosine in Neurodegenerative Diseases: From the Bench to the Bedside.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antioxidants; Humans; Inosine; Multiple Sclerosis; | 2022 |
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom | 2015 |
Urate as a Marker of Risk and Progression of Neurodegenerative Disease.
Topics: Animals; Biomarkers; Clinical Trials as Topic; Disease Progression; Humans; Neurodegenerative Diseas | 2017 |
7 other studies available for uric acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Unbiased metabolome screen links serum urate to risk of Alzheimer's disease.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Genome-Wide Association Study; Humans; Mendelian R | 2022 |
The Influence of Agricultural Work and Plasma Uric Acid on Hospital Admission for Alzheimer's Disease.
Topics: Alzheimer Disease; Dementia, Vascular; Hospitals; Humans; Neurodegenerative Diseases; Pesticides; Ur | 2023 |
Uric acid level may not be reduced in essential tremor.
Topics: Age of Onset; Biomarkers; Case-Control Studies; Cholesterol; Essential Tremor; Female; Humans; Male; | 2018 |
Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3β/Nrf2/GCLC pathways.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Dros | 2019 |
Serum and cerebrospinal fluid urate levels in synucleinopathies versus tauopathies.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cross-Sectional Studies; Female; Humans; Male; Middle Ag | 2013 |
URIC ACID IN THE CEREBROSPINAL FLUID IN CEREBRAL ATROPHY.
Topics: Atrophy; Blood Chemical Analysis; Brain Diseases; Cerebrospinal Fluid; Humans; Nervous System Diseas | 1965 |
Time-course of oxidation of lipids in human cerebrospinal fluid in vitro.
Topics: Adult; Aged; Ascorbic Acid; Cerebrospinal Fluid; Chelating Agents; Copper; Humans; Iron; Kinetics; L | 2000 |