uric acid has been researched along with Nerve Degeneration in 7 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid and DA levels were significantly lower in the substantia nigra of PD by 54% and 85%, respectively." | 1.29 | Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. ( Church, WH; Ward, VL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schlesinger, I | 1 |
| Schlesinger, N | 1 |
| Sloane, JA | 1 |
| Blitz, D | 1 |
| Margolin, Z | 1 |
| Vartanian, T | 1 |
| Cipriani, S | 1 |
| Desjardins, CA | 1 |
| Burdett, TC | 1 |
| Xu, Y | 1 |
| Xu, K | 1 |
| Schwarzschild, MA | 1 |
| Moor, E | 1 |
| Shohami, E | 1 |
| Kanevsky, E | 1 |
| Grigoriadis, N | 1 |
| Symeonidou, C | 1 |
| Kohen, R | 1 |
| Church, WH | 1 |
| Ward, VL | 1 |
| Hill, IE | 1 |
| Murray, C | 1 |
| Richard, J | 1 |
| Rasquinha, I | 1 |
| MacManus, JP | 1 |
| Liu, T | 1 |
| Knight, KR | 1 |
| Tracey, DJ | 1 |
1 review available for uric acid and Nerve Degeneration
| Article | Year |
|---|---|
A clear and present danger: endogenous ligands of Toll-like receptors.
Topics: Apoptosis; Central Nervous System; Central Nervous System Diseases; Extracellular Matrix; Heat-Shock | 2010 |
6 other studies available for uric acid and Nerve Degeneration
| Article | Year |
|---|---|
Re: Gout and risk of Parkinson disease: a prospective study.
Topics: Comorbidity; Dose-Response Relationship, Drug; Free Radical Scavengers; Gout; Gout Suppressants; Hum | 2008 |
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Dopaminergic Neurons; Mesencephalon; Mice; Mice, I | 2012 |
Impairment of the ability of the injured aged brain in elevating urate and ascorbate.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Axons; Brain Injuries; Corpus Callosum; Extracellular M | 2006 |
Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation.
Topics: Aged; Ascorbic Acid; Brain Chemistry; Dopamine; Female; Humans; Male; Nerve Degeneration; Neural Pat | 1994 |
Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspases; Cell Nucleus; Cholinesterase Inhibitors; Com | 2000 |
Hyperalgesia due to nerve injury-role of peroxynitrite.
Topics: Animals; Hyperalgesia; Hyperthermia, Induced; Immunohistochemistry; Male; Nerve Compression Syndrome | 2000 |