uric acid has been researched along with Motor Neuron Disease in 2 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased uric acid may have a protective effect in motor neuron diseases (MNDs)." | 4.31 | Prevalence of motor neuron diseases in gout patients: a nationwide population-based cohort study. ( Choi, H; Jun, JB; Kang, DR; Kim, JH; Kim, SH; Kwon, HS; Park, S; Park, Y, 2023) |
| "This study investigated the epidemiological evidence for a protective role of high serum concentration of uric acid, for which we used gout as a proxy, in the aetiology of MS, PD or MND." | 3.81 | Clinical associations between gout and multiple sclerosis, Parkinson's disease and motor neuron disease: record-linkage studies. ( Goldacre, MJ; Pakpoor, J; Ramagopalan, SV; Seminog, OO, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kwon, HS | 1 |
| Park, Y | 1 |
| Kim, JH | 1 |
| Kim, SH | 1 |
| Jun, JB | 1 |
| Park, S | 1 |
| Kang, DR | 1 |
| Choi, H | 1 |
| Pakpoor, J | 1 |
| Seminog, OO | 1 |
| Ramagopalan, SV | 1 |
| Goldacre, MJ | 1 |
2 other studies available for uric acid and Motor Neuron Disease
| Article | Year |
|---|---|
Prevalence of motor neuron diseases in gout patients: a nationwide population-based cohort study.
Topics: Cohort Studies; Female; Gout; Humans; Motor Neuron Disease; Prevalence; Uric Acid | 2023 |
Clinical associations between gout and multiple sclerosis, Parkinson's disease and motor neuron disease: record-linkage studies.
Topics: Adult; Aged; Databases, Factual; England; Female; Gout; Hospitalization; Humans; Male; Middle Aged; | 2015 |