uric acid has been researched along with Lupus Nephritis in 13 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Lupus Nephritis: Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objectives of this study are to assess serum different uric acid levels among systemic lupus erythematosus patients with or without active lupus nephritis in comparison to healthy controls and to study the relation of baseline uric acid levels to the development of new-onset renal damage in lupus nephritis." | 8.02 | Serum uric acid as a sensitive concordant marker with lupus nephritis and new onset of renal damage: a prospective cohort study. ( Abdel-Fattah, MM; Almalki, A; Attar, M; Desouky, DE; Elnady, B, 2021) |
| " Multiple logistic analysis adjusting for body mass index (BMI), lupus nephritis, serum uric acid, and estimated glomerular filtration rate revealed HCQ treatment was associated with exceedingly lower risk of preeclampsia in SLE pregnancy (odds ratio (OR) 0." | 7.91 | Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia. ( Cha, HS; Chae, J; Choi, SJ; Kim, YM; Oh, S; Roh, CR; Seo, MR, 2019) |
| " Lupus flares were predicted by HCQ discontinuation, a history of lupus nephritis, high pre-pregnancy serum uric acid and low C4 levels." | 7.81 | Hydroxychloroquine and pregnancy on lupus flares in Korean patients with systemic lupus erythematosus. ( Ju, JH; Ko, HS; Koh, JH; Kwok, SK; Park, SH, 2015) |
| "The aim of the present study is to assess the association of elevated serum uric acid (UA) with lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients." | 7.77 | Association of serum uric acid with lupus nephritis in systemic lupus erythematosus. ( Li, C; Liang, Y; Xi, W; Yang, Z; Zhong, R; Zhu, Y, 2011) |
| "Uric acid has been recognised as a potential marker of endothelial dysfunction and kidney disease but there are scarce data about its importance in systemic lupus erythematosus (SLE) nephritis." | 5.48 | Serum uric acid levels are associated with lupus nephritis in patients with normal renal function. ( Bonfá, E; Borba, EF; Calich, AL; da Rocha, LF; Fuller, R; Ugolini-Lopes, MR, 2018) |
| "The objectives of this study are to assess serum different uric acid levels among systemic lupus erythematosus patients with or without active lupus nephritis in comparison to healthy controls and to study the relation of baseline uric acid levels to the development of new-onset renal damage in lupus nephritis." | 4.02 | Serum uric acid as a sensitive concordant marker with lupus nephritis and new onset of renal damage: a prospective cohort study. ( Abdel-Fattah, MM; Almalki, A; Attar, M; Desouky, DE; Elnady, B, 2021) |
| "Lupus nephritis (LN) is closely associated with hyperuricemia, and uric acid is considered a risk factor for renal involvement in systemic lupus erythematosus (SLE)." | 4.02 | Serum uric acid as a predictor for nephritis in Egyptian patients with systemic lupus erythematosus. ( Badr, FM; Hafez, EA; Hassan, SAE; Teama, MAM, 2021) |
| " Multiple logistic analysis adjusting for body mass index (BMI), lupus nephritis, serum uric acid, and estimated glomerular filtration rate revealed HCQ treatment was associated with exceedingly lower risk of preeclampsia in SLE pregnancy (odds ratio (OR) 0." | 3.91 | Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia. ( Cha, HS; Chae, J; Choi, SJ; Kim, YM; Oh, S; Roh, CR; Seo, MR, 2019) |
| " Lupus flares were predicted by HCQ discontinuation, a history of lupus nephritis, high pre-pregnancy serum uric acid and low C4 levels." | 3.81 | Hydroxychloroquine and pregnancy on lupus flares in Korean patients with systemic lupus erythematosus. ( Ju, JH; Ko, HS; Koh, JH; Kwok, SK; Park, SH, 2015) |
| "3% of the ones with MN, in 35% of crescentic group, in 42% of FSGS group, in 30% of patients with MPGN and in 33% of the ones with lupus nephritis uric acid levels were found as elevated." | 3.80 | Comparison of laboratory findings in patients with glomerulonephritis classified according to histopathologic diagnosis. ( Bilen, S; Duranay, M; Kirac, Y, 2014) |
| "The aim of the present study is to assess the association of elevated serum uric acid (UA) with lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients." | 3.77 | Association of serum uric acid with lupus nephritis in systemic lupus erythematosus. ( Li, C; Liang, Y; Xi, W; Yang, Z; Zhong, R; Zhu, Y, 2011) |
| "A total of 123 biopsy-proven lupus nephritis (LN) patients were included in this retrospective observational study." | 3.01 | Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis. ( Cai, Y; Feng, Y; Han, Y; Huang, Q; Lu, X; Qin, J; Qiu, R; Xiao, S; Yang, M; Zheng, L, 2023) |
| "Uric acid has been considered a key molecule in the pathogenesis of some conditions such as metabolic syndrome, hypertension, and kidney disease as it is produced by injured cells and promotes immune-inflammatory responses." | 2.66 | Uric acid and kidney damage in systemic lupus erythematosus. ( Dos Santos, M; Moresco, RN; Veronese, FV, 2020) |
| "However, all patients with lupus nephritis have by definition chronic kidney disease (CKD) as they will have proteinuria with varying degrees of renal impairment." | 2.49 | Renoprotective strategies in lupus nephritis: beyond immunosuppression. ( Griffin, B; Lightstone, L, 2013) |
| "Uric acid has been recognised as a potential marker of endothelial dysfunction and kidney disease but there are scarce data about its importance in systemic lupus erythematosus (SLE) nephritis." | 1.48 | Serum uric acid levels are associated with lupus nephritis in patients with normal renal function. ( Bonfá, E; Borba, EF; Calich, AL; da Rocha, LF; Fuller, R; Ugolini-Lopes, MR, 2018) |
| "Hyperuricemia is an important predictor for poor prognosis in patients with LN." | 1.43 | Hyperuricemia is an independent risk factor for renal pathological damage and poor prognosis in lupus nephritis patients. ( Chen, M; Li, G; Li, J; Tang, X; Wang, X; Xie, T; Yin, H; Zhang, W; Zuo, X, 2016) |
| "The coexistence of systemic lupus erythematosus and tophaceous gout is very rare." | 1.28 | A case of multiple urate deposition, without gouty attacks, in a patient with systemic lupus erythematosus. ( Kurita, Y; Numata, K; Ogawa, H; Tsuboi, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 5 (38.46) | 2.80 |
| Authors | Studies |
|---|---|
| Han, Y | 3 |
| Lu, X | 3 |
| Xiao, S | 3 |
| Qin, J | 3 |
| Zheng, L | 3 |
| Feng, Y | 3 |
| Cai, Y | 3 |
| Qiu, R | 3 |
| Huang, Q | 3 |
| Yang, M | 3 |
| Dos Santos, M | 1 |
| Veronese, FV | 1 |
| Moresco, RN | 1 |
| Elnady, B | 1 |
| Almalki, A | 1 |
| Abdel-Fattah, MM | 1 |
| Desouky, DE | 1 |
| Attar, M | 1 |
| Hafez, EA | 1 |
| Hassan, SAE | 1 |
| Teama, MAM | 1 |
| Badr, FM | 1 |
| Liu, H | 1 |
| Peng, L | 1 |
| Ma, J | 1 |
| He, L | 1 |
| Long, K | 1 |
| Ouyang, X | 1 |
| Wu, C | 1 |
| Xie, M | 1 |
| Dai, L | 1 |
| Cai, X | 1 |
| Calich, AL | 1 |
| Borba, EF | 1 |
| Ugolini-Lopes, MR | 1 |
| da Rocha, LF | 1 |
| Bonfá, E | 1 |
| Fuller, R | 1 |
| Seo, MR | 1 |
| Chae, J | 1 |
| Kim, YM | 1 |
| Cha, HS | 1 |
| Choi, SJ | 1 |
| Oh, S | 1 |
| Roh, CR | 1 |
| Griffin, B | 1 |
| Lightstone, L | 1 |
| Kirac, Y | 1 |
| Bilen, S | 1 |
| Duranay, M | 1 |
| Koh, JH | 1 |
| Ko, HS | 1 |
| Kwok, SK | 1 |
| Ju, JH | 1 |
| Park, SH | 1 |
| Xie, T | 1 |
| Chen, M | 1 |
| Tang, X | 1 |
| Yin, H | 1 |
| Wang, X | 1 |
| Li, G | 1 |
| Li, J | 1 |
| Zuo, X | 1 |
| Zhang, W | 1 |
| Yang, Z | 1 |
| Liang, Y | 1 |
| Xi, W | 1 |
| Zhu, Y | 1 |
| Li, C | 1 |
| Zhong, R | 1 |
| Kurita, Y | 1 |
| Tsuboi, R | 1 |
| Numata, K | 1 |
| Ogawa, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Three-arm, Multicenter, Open-label Randomized Controlled Trial of Hydroxychloroquine and Low-dose Prednisone on Recurrent Spontaneous Abortion With Undifferentiated Connective Tissue Diseases: Protocol for the Immunosuppressant Regimens for Living FEtus[NCT03671174] | 420 participants (Anticipated) | Interventional | 2019-08-02 | Recruiting | |||
| Value of Uric Acid as Early Predictor of Lupus Nephritis in Assiut University Hospital[NCT05402735] | 100 participants (Anticipated) | Observational | 2022-06-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for uric acid and Lupus Nephritis
| Article | Year |
|---|---|
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis.
Topics: East Asian People; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Retrospec | 2023 |
Uric acid and kidney damage in systemic lupus erythematosus.
Topics: Humans; Kidney; Kidney Diseases; Lupus Erythematosus, Systemic; Lupus Nephritis; Uric Acid | 2020 |
Renoprotective strategies in lupus nephritis: beyond immunosuppression.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Disease Progression; Dyslipidemias; Humans; | 2013 |
10 other studies available for uric acid and Lupus Nephritis
| Article | Year |
|---|---|
Serum uric acid as a sensitive concordant marker with lupus nephritis and new onset of renal damage: a prospective cohort study.
Topics: Biomarkers; Case-Control Studies; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Pr | 2021 |
Serum uric acid as a predictor for nephritis in Egyptian patients with systemic lupus erythematosus.
Topics: Adult; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Disease Progression; Egypt; Female | 2021 |
Low expression of estrogen receptor β in renal tubular epithelial cells may cause hyperuricemia in premenopausal patients with systemic lupus erythematosus.
Topics: Adult; Biopsy; Case-Control Studies; Creatinine; Epithelial Cells; Estrogen Receptor beta; Female; G | 2021 |
Serum uric acid levels are associated with lupus nephritis in patients with normal renal function.
Topics: Adult; Biomarkers; Cross-Sectional Studies; Female; Humans; Kidney; Kidney Function Tests; Lupus Nep | 2018 |
Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia.
Topics: Adult; Antirheumatic Agents; Female; Gestational Age; Humans; Hydroxychloroquine; Infant, Newborn; L | 2019 |
Comparison of laboratory findings in patients with glomerulonephritis classified according to histopathologic diagnosis.
Topics: Analysis of Variance; Biopsy; C-Reactive Protein; Complement C3; Complement C4; Female; Glomerulonep | 2014 |
Hydroxychloroquine and pregnancy on lupus flares in Korean patients with systemic lupus erythematosus.
Topics: Adult; Antirheumatic Agents; Apgar Score; Female; Fetal Growth Retardation; Follow-Up Studies; Human | 2015 |
Hyperuricemia is an independent risk factor for
renal pathological damage and poor prognosis in
lupus nephritis patients.
Topics: Blood Urea Nitrogen; Creatinine; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertens | 2016 |
Association of serum uric acid with lupus nephritis in systemic lupus erythematosus.
Topics: Adult; Asian People; Blood Chemical Analysis; Female; Humans; Lupus Nephritis; Male; Predictive Valu | 2011 |
A case of multiple urate deposition, without gouty attacks, in a patient with systemic lupus erythematosus.
Topics: Adult; Female; Gout; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Lupus Ne | 1989 |