Page last updated: 2024-10-20

uric acid and Lead Poisoning

uric acid has been researched along with Lead Poisoning in 47 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Lead Poisoning: Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.

Research Excerpts

ExcerptRelevanceReference
"We found that albumin, bilirubin, urea, and creatinine levels were significantly lower and AST, total protein, and globulin levels were higher in children with lead poisoning than in controls."8.02Decreased serum bilirubin levels in children with lead poisoning. ( Chen, H; Chen, S; Chen, Z; Ye, M; Zhang, T, 2021)
" We examined the development of gout and an increased uric acid level in relation to lead, adjusting for other known risk factors."7.70Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study. ( Hu, H; Kim, R; Liang, MH; Shadick, NA; Sparrow, D; Weiss, S, 2000)
"Ten patients with gout, hypertension, and mild to moderate renal insufficiency were studied for possible lead nephropathy by measuring stimulated urinary lead excretion."7.67Occult lead intoxication in patients with gout and kidney disease. ( Cecere, FA; Saylor, RP; Wright, LF, 1984)
"Chronic lead nephtropathy, secondary gout (lead-gout) and porphyrinuria may develop after long lasting professional exposure to lead."7.65[Chronic lead poisoning: Lead gout with giant tophi on the skin, nephrophathy and porphyrinopathy]. ( Künzig, M; Orfanos, CE, 1975)
"Nine people from four families living in rural parts of Scotland have been found to suffer from clinical or biochemical effects of lead poisoning."7.65Lead poisoning in rural Scotland. ( Beattie, AD; Dagg, JH; Goldberg, A; Ronald, J; Wang, I, 1972)
"We found that albumin, bilirubin, urea, and creatinine levels were significantly lower and AST, total protein, and globulin levels were higher in children with lead poisoning than in controls."4.02Decreased serum bilirubin levels in children with lead poisoning. ( Chen, H; Chen, S; Chen, Z; Ye, M; Zhang, T, 2021)
"The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear."3.80The effect of occupational exposure to lead on the non-enzymatic antioxidant system. ( Dobrakowski, M; Kasperczyk, S; Świętochowska, E; Wielkoszyński, T; Zalejska-Fiolka, J, 2014)
" We examined the development of gout and an increased uric acid level in relation to lead, adjusting for other known risk factors."3.70Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study. ( Hu, H; Kim, R; Liang, MH; Shadick, NA; Sparrow, D; Weiss, S, 2000)
"Ten patients with gout, hypertension, and mild to moderate renal insufficiency were studied for possible lead nephropathy by measuring stimulated urinary lead excretion."3.67Occult lead intoxication in patients with gout and kidney disease. ( Cecere, FA; Saylor, RP; Wright, LF, 1984)
"Chronic lead nephtropathy, secondary gout (lead-gout) and porphyrinuria may develop after long lasting professional exposure to lead."3.65[Chronic lead poisoning: Lead gout with giant tophi on the skin, nephrophathy and porphyrinopathy]. ( Künzig, M; Orfanos, CE, 1975)
"Nine people from four families living in rural parts of Scotland have been found to suffer from clinical or biochemical effects of lead poisoning."3.65Lead poisoning in rural Scotland. ( Beattie, AD; Dagg, JH; Goldberg, A; Ronald, J; Wang, I, 1972)
"Uric acid nephrolithiasis results from supersaturation, strongly influenced by low urine pH, rather than altered urate turnover."2.43Uric acid elimination in the urine. Pathophysiological implications. ( Marangella, M, 2005)
"Metallothionein (MT) is a protein with function of heavy metal detoxification."1.56The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms. ( Chuang, HY; Dai, CY; Lee, SS; Lin, CI; Wang, CL; Yang, CC, 2020)
"Although nephrotoxicity is common following exposure to lead, the dose-response relationship in adults with occupational exposure is not well understood because information is lacking on early nephrotoxic effects."1.26Occupational exposure to lead: effects on renal function. ( Hammond, PB; Hanenson, IB; Hong, CD; Lerner, S; Pesce, AJ; Pollak, VE, 1980)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199035 (74.47)18.7374
1990's2 (4.26)18.2507
2000's4 (8.51)29.6817
2010's4 (8.51)24.3611
2020's2 (4.26)2.80

Authors

AuthorsStudies
Yang, CC2
Lin, CI1
Lee, SS2
Wang, CL1
Dai, CY1
Chuang, HY2
Ye, M1
Zhang, T1
Chen, Z1
Chen, S1
Chen, H1
Chen, HI1
Chiu, YW1
Tsai, CH1
Sharma, S1
Shrivastava, S1
Shukla, S1
Dobrakowski, M2
Zalejska-Fiolka, J1
Wielkoszyński, T1
Świętochowska, E1
Kasperczyk, S2
Kasperczyk, A1
Pawlas, N1
Birkner, E1
Hudziec, E1
Chwalińska, E1
RICHET, G2
ALBAHARY, C1
ARDAILLOU, R2
SULTAN, C1
MOREL-MAROGER, A1
MIGNON, F1
Marangella, M1
Weaver, VM1
Jaar, BG1
Schwartz, BS1
Todd, AC1
Ahn, KD1
Wen, J1
Parsons, PJ1
Lee, BK1
Hernández-Serrato, MI1
Fortoul, TI1
Rojas-Martínez, R1
Mendoza-Alvarado, LR1
Canales-Treviño, L1
Bochichio-Riccardelli, T1
Avila-Costa, MR1
Olaiz-Fernández, G1
Reynolds, PP1
Knapp, MJ1
Baraf, HS1
Holmes, EW1
Wright, LF1
Saylor, RP1
Cecere, FA1
Yu, CF1
Batuman, V1
Maesaka, JK1
Haddad, B1
Tepper, E1
Landy, E1
Wedeen, RP1
Yu, TF1
Hong, CD1
Hanenson, IB1
Lerner, S1
Hammond, PB1
Pesce, AJ1
Pollak, VE1
Tak, HK1
Wilcox, WR1
Cooper, SM1
Lombardo, JV1
Terlinsky, A1
Chester, AC1
Preuss, HG1
Reif, MC1
Constantiner, A1
Levitt, MF1
Balkarov, IM1
Dupliankin, SA1
Eliseeva, NA1
Kondakhchan, MA1
Barashkov, GK1
Lebedeva, MV1
Kriachnevskaia, LN1
Shadick, NA1
Kim, R1
Weiss, S1
Liang, MH1
Sparrow, D1
Hu, H1
Boss, GR1
Seegmiller, JE2
Cameron, JS1
Simmonds, HA1
Orfanos, CE1
Künzig, M1
Watts, RW1
Kelley, WN1
Rapado, A2
Scott, JT1
de Vries, A1
Wyngaarden, JB1
Zöllner, N1
Emmerson, BT6
Ravenscroft, PJ1
Caimi, G1
Lo Presti, R1
Pinto de Almeida, AR1
Carvalho, FM1
Spinola, AG1
Rocha, H1
Gouda, IM1
Abdel Aziz, SA1
Lotfi, MM1
Ahmed, AA1
Soliman, MM1
Beck, LH1
Ruiz, M1
Furió Bacete, V1
Juárez Centeno, D1
Beattie, AD2
Dagg, JH1
Goldberg, A3
Wang, I1
Ronald, J1
Moore, MR1
Devenay, WT1
Miller, AR1
Mirosch, W1
Douglas, JB1
Lejeune, E2
Tolot, F2
Meunier, P2
Knowles, BR1
Gibson, SL1
Mackenzie, JC1
Lilis, R1
Gavrilescu, N1
Nestorescu, B1
Dumitriu, C1
Roventa, A1
Ball, GV1
Sorensen, LB1
Klinenberg, JR1

Reviews

3 reviews available for uric acid and Lead Poisoning

ArticleYear
Uric acid elimination in the urine. Pathophysiological implications.
    Contributions to nephrology, 2005, Volume: 147

    Topics: Acute Kidney Injury; Humans; Kidney; Kidney Calculi; Lead Poisoning; Uric Acid

2005
Hyperuricemia and gout. Classification, complications and management.
    The New England journal of medicine, 1979, Jun-28, Volume: 300, Issue:26

    Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Human

1979
[Physiopathological aspects of secondary hyperuricemia].
    Recenti progressi in medicina, 1991, Volume: 82, Issue:11

    Topics: Acute Disease; Coronary Disease; Drug-Related Side Effects and Adverse Reactions; Fructose; Glycogen

1991

Other Studies

44 other studies available for uric acid and Lead Poisoning

ArticleYear
The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms.
    Scientific reports, 2020, 06-15, Volume: 10, Issue:1

    Topics: Acetylglucosaminidase; Adult; Biomarkers; Female; Humans; Kidney; Lead; Lead Poisoning; Male; Metall

2020
Decreased serum bilirubin levels in children with lead poisoning.
    The Journal of international medical research, 2021, Volume: 49, Issue:2

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Case-Control Studies; Child; Child, Pr

2021
Metallothionein 1A polymorphisms may influence urine uric acid and N-acetyl-beta-D-glucosaminidase (NAG) excretion in chronic lead-exposed workers.
    Toxicology, 2013, Apr-05, Volume: 306

    Topics: Acetylglucosaminidase; Adult; Alleles; Biomarkers; Cross-Sectional Studies; DNA; Female; Genotype; H

2013
Reversal of lead-induced toxicity due to the effect of antioxidants.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2013, Volume: 32, Issue:2

    Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Brain; Cholesterol; Glutathione; Inject

2013
The effect of occupational exposure to lead on the non-enzymatic antioxidant system.
    Medycyna pracy, 2014, Volume: 65, Issue:4

    Topics: Adult; Albumins; alpha-Tocopherol; Antioxidants; Bilirubin; Chemical Industry; Environmental Monitor

2014
Association between subchronic and chronic lead exposure and levels of antioxidants and chemokines.
    International archives of occupational and environmental health, 2016, Volume: 89, Issue:7

    Topics: Adult; Antioxidants; Bilirubin; Chemokine CCL4; Chemokine CXCL10; Chemokines; Humans; Interleukin-8;

2016
[THE KIDNEY IN CHRONIC LEAD POISONING].
    Revue francaise d'etudes cliniques et biologiques, 1964, Volume: 9

    Topics: Edetic Acid; Electrons; Gout; Humans; Hypertension; Kidney; Kidney Diseases; Kidney Function Tests;

1964
[SECONDARY GOUT IN CHRONIC NEPHROPATHIES].
    La Presse medicale, 1965, Mar-06, Volume: 73

    Topics: Amyloidosis; Blood; Colchicine; Drug Therapy; Gout; Humans; Hypertension; Hypertension, Renal; Kidne

1965
Associations among lead dose biomarkers, uric acid, and renal function in Korean lead workers.
    Environmental health perspectives, 2005, Volume: 113, Issue:1

    Topics: Adolescent; Adult; Age Factors; Biomarkers; Blood Pressure; Creatinine; Drug Interactions; Female; H

2005
Lead blood concentrations and renal function evaluation: study in an exposed Mexican population.
    Environmental research, 2006, Volume: 100, Issue:2

    Topics: Adult; Blood Proteins; Cooking and Eating Utensils; Creatinine; Cross-Sectional Studies; Environment

2006
Moonshine and lead. Relationship to the pathogenesis of hyperuricemia in gout.
    Arthritis and rheumatism, 1983, Volume: 26, Issue:9

    Topics: Adult; Alcohol Drinking; Edetic Acid; Female; Gout; Humans; Kidney Diseases; Latex Fixation Tests; L

1983
Occult lead intoxication in patients with gout and kidney disease.
    The Journal of rheumatology, 1984, Volume: 11, Issue:4

    Topics: Adult; Aged; Alcohol Drinking; Creatinine; Edetic Acid; Female; Gout; Humans; Kidney Diseases; Lead;

1984
[Secondary gut].
    Zhonghua nei ke za zhi, 1983, Volume: 22, Issue:6

    Topics: Adult; Age Factors; Aged; Female; Gout; Humans; Lead Poisoning; Male; Middle Aged; Polycythemia; Uri

1983
The role of lead in gout nephropathy.
    The New England journal of medicine, 1981, Feb-26, Volume: 304, Issue:9

    Topics: Adult; Aged; Creatinine; Edetic Acid; Gout; Humans; Kidney; Kidney Diseases; Kidney Function Tests;

1981
Lead nephropathy and gout.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1983, Volume: 2, Issue:5

    Topics: Adolescent; Adult; Aged; Child, Preschool; Creatinine; Female; Glomerular Filtration Rate; Gout; Hum

1983
Occupational exposure to lead: effects on renal function.
    Kidney international, 1980, Volume: 18, Issue:4

    Topics: Adult; Environmental Exposure; Glomerular Filtration Rate; Glucose; Humans; Inulin; Kidney Glomerulu

1980
The effect of lead upon urate nucleation.
    Arthritis and rheumatism, 1981, Volume: 24, Issue:10

    Topics: Chemical Phenomena; Chemistry; Crystallization; Gout; Humans; Lead; Lead Poisoning; Uric Acid

1981
Tubulointerstitial diseases.
    American family physician, 1980, Volume: 21, Issue:1

    Topics: Analgesics; Drug Hypersensitivity; Glomerular Filtration Rate; Humans; Hypercalcemia; Hypokalemia; I

1980
Chronic gouty nephropathy: a vanishing syndrome?
    The New England journal of medicine, 1981, Feb-26, Volume: 304, Issue:9

    Topics: Animals; Gout; Humans; Kidney Diseases; Lead Poisoning; Lesch-Nyhan Syndrome; Lymphoproliferative Di

1981
[Kidney involvement in industrial exposure to lead and cadmium].
    Terapevticheskii arkhiv, 1995, Volume: 67, Issue:5

    Topics: Adult; Air Pollutants, Occupational; Cadmium Poisoning; Ceramics; Coloring Agents; Female; Humans; K

1995
Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study.
    The Journal of rheumatology, 2000, Volume: 27, Issue:7

    Topics: Age Factors; Aged; Alcohol Drinking; Blood Pressure; Body Mass Index; Bone Density; Cohort Studies;

2000
Gout and crystal-related nephropathy.
    Contributions to nephrology, 1979, Volume: 16

    Topics: Adenine Phosphoribosyltransferase; Female; Gout; Humans; Kidney; Kidney Calculi; Kidney Diseases; Le

1979
[Chronic lead poisoning: Lead gout with giant tophi on the skin, nephrophathy and porphyrinopathy].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1975, Volume: 26, Issue:11

    Topics: Aged; Book Industry; Chronic Disease; Edetic Acid; Gout; Humans; Kidney Diseases; Lead; Lead Poisoni

1975
Panel discussion: hyperuricemia as a risk factor.
    Advances in experimental medicine and biology, 1977, Volume: 76B

    Topics: Alcohol Drinking; Allopurinol; Blood Proteins; Body Weight; Coronary Disease; Diabetes Complications

1977
Abnormal renal urate homeostasis in systemic disorders.
    Nephron, 1975, Volume: 14, Issue:1

    Topics: Alcoholism; Diabetes Mellitus; Female; Fructose Intolerance; Glomerular Filtration Rate; Glycogen St

1975
Renal dysfunction in Brazilian lead workers.
    American journal of nephrology, 1987, Volume: 7, Issue:6

    Topics: Adult; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases; Kidney Function Tests; Lead

1987
Changes in some kidney functions in experimentally lead-poisoned goats.
    Archiv fur experimentelle Veterinarmedizin, 1986, Volume: 40, Issue:2

    Topics: Animals; Calcium; Creatinine; Female; Goats; Kidney Diseases; Lead Poisoning; Phosphorus; Potassium;

1986
Requiem for gouty nephropathy.
    Kidney international, 1986, Volume: 30, Issue:2

    Topics: Acute Disease; Aged; Animals; Chronic Disease; Disease Models, Animal; Gout; Humans; Kidney; Kidney

1986
[Renal insufficiency and uric gout in a lead worker (clinicopathologic conference)].
    Revista clinica espanola, 1985, Volume: 177, Issue:7

    Topics: Aged; Gout; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Lead Poisoning; Male; Myocardium;

1985
Medical Grand Rounds from the University of Alabama Medical Center. Lead poisoning.
    Southern medical journal, 1972, Volume: 65, Issue:3

    Topics: Adult; Aged; Alcoholism; Amyotrophic Lateral Sclerosis; Anemia, Macrocytic; Brain Diseases; Diagnosi

1972
Chronic lead nephropathy.
    Kidney international, 1973, Volume: 4, Issue:1

    Topics: Adult; Bone and Bones; Chelating Agents; Child; Child, Preschool; Edetic Acid; Environmental Exposur

1973
Relationship between gout and arterial hypertension.
    Advances in experimental medicine and biology, 1974, Volume: 41

    Topics: Acute Disease; Adult; Aged; Blood Pressure; Chronic Disease; Diabetes Complications; Female; Gout; H

1974
Lead poisoning in rural Scotland.
    British medical journal, 1972, May-27, Volume: 2, Issue:5812

    Topics: Adult; Aged; Anemia; Female; Humans; Kidney Diseases; Lead; Lead Poisoning; Male; Middle Aged; Rural

1972
Environmental lead pollution in an urban soft-water area.
    British medical journal, 1972, May-27, Volume: 2, Issue:5812

    Topics: Adolescent; Adult; Amino Acids; Child; Health Surveys; Humans; Hydro-Lyases; Lead; Lead Poisoning; L

1972
The relative contributions of tubular reabsorption and secretion to urate excretion in lead nephropathy.
    Australian and New Zealand journal of medicine, 1971, Volume: 1, Issue:4

    Topics: Absorption; Adult; Female; Glomerular Filtration Rate; Gout; Humans; Insulin; Kidney Failure, Chroni

1971
[Gout and hyperuricemia associated with lead poisoning].
    Revue du rhumatisme et des maladies osteo-articulaires, 1969, Volume: 36, Issue:4

    Topics: Adult; Glomerular Filtration Rate; Gout; Humans; Kidney Failure, Chronic; Kidney Tubules; Lead Poiso

1969
Triglyceride concentrations in primary gout and gout of chronic lead nephropathy.
    Metabolism: clinical and experimental, 1971, Volume: 20, Issue:8

    Topics: Adult; Aged; Alcoholic Beverages; Cholesterol; Gout; Humans; Kidney Failure, Chronic; Lead Poisoning

1971
The diagnosis of industrial lead poisoning.
    British journal of industrial medicine, 1968, Volume: 25, Issue:1

    Topics: Adult; Blood Cell Count; Blood Pressure Determination; Environmental Exposure; Hematocrit; Humans; K

1968
Nephropathy in chronic lead poisoning.
    British journal of industrial medicine, 1968, Volume: 25, Issue:3

    Topics: Adult; Chronic Disease; Colic; Creatinine; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Ki

1968
The clinical differentiation of lead gout from primary gout.
    Arthritis and rheumatism, 1968, Volume: 11, Issue:5

    Topics: Alcohol Drinking; Body Height; Body Weight; Child Behavior Disorders; Diagnosis, Differential; Envir

1968
[Lead and uric acid metabolism].
    Revue medicale de la Suisse romande, 1968, Volume: 88, Issue:3

    Topics: Humans; Lead Poisoning; Male; Middle Aged; Uric Acid

1968
Pathogenesis of hyperuricemia in saturnine gout.
    The New England journal of medicine, 1969, 05-29, Volume: 280, Issue:22

    Topics: Adult; Alcoholic Beverages; Alcoholism; Carbon Isotopes; Creatinine; Diet; Food Contamination; Glyci

1969
Saturnine gout--a moonshine malady.
    The New England journal of medicine, 1969, May-29, Volume: 280, Issue:22

    Topics: Alcoholic Beverages; Alcoholism; Gout; Humans; Kidney Diseases; Lead Poisoning; Uric Acid

1969
The renal excretion of urate in chronic lead nephropathy.
    Australasian annals of medicine, 1965, Volume: 14, Issue:4

    Topics: Adult; Creatine; Female; Gout; Humans; In Vitro Techniques; Kidney Diseases; Kidney Function Tests;

1965