uric acid has been researched along with Insulin Sensitivity in 424 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased blood lactate or uric acid (UA) levels are associated with an increased risk of metabolic syndrome (MS)." | 9.30 | Interaction Between Lactate and Uric Acid is Associated With a Higher Prevalence of Metabolic Syndrome: A Community-Based Study. ( Li, F; Pan, H; Ren, M; Wu, M; Xu, M; Yan, D; Zhang, J, 2019) |
| "To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents." | 9.22 | Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance. ( Chan, TF; Huang, HL; Lee, CH; Lee, CY; Lin, WT; Tsai, S; Wang, TN; Wu, PW; Yang, YC, 2016) |
| "Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia." | 9.20 | Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. ( Afsar, B; ALanaspa, M; Bakan, A; Elcioglu, OC; Erek, A; Johnson, RJ; Kanbay, M; Kostek, O; Mutlu, HH; Odabas, AR; Ozkok, A; Semerci, A; Sharma, S; Smits, G; Takir, M; Telci, O, 2015) |
| " Serum insulin, glucose, C-reactive protein (CRP), lipids, uric acid, YKL-40 and blood pressure were measured and insulin sensitivity was calculated (HOMA) at the beginning and end of each study phase." | 9.14 | Effect of moxonidine and amlodipine on serum YKL-40, plasma lipids and insulin sensitivity in insulin-resistant hypertensive patients-a randomized, crossover trial. ( Majer, J; Masajtis-Zagajewska, A; Nowicki, M, 2010) |
| "This meta-analysis aimed to investigate whether uric acid lowering treatment can improve β-cell function and insulin sensitivity." | 9.12 | Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials. ( Ma, G; Wang, T; Zong, Q, 2021) |
| "To evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR)." | 9.11 | [Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)]. ( Barskova, VG; Eliseev, MS; Iakunina, IA; Il'inykh, EV; Kudaeva, FM; Nasonov, EL; Tsapina, TN; Volkov, AV; Zilov, AV, 2005) |
| "These favourable effects of comicronised fenofibrate both on lipid and non lipid parameters, including insulin sensitivity, may confer to this product a particular interest in the treatment of patients with polymetabolic syndrome X." | 9.09 | Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X. ( Blane, G; Idzior-Walus, B; Kawalec, E; Rostworowski, W; Sieradzki, J; Wójcik, J; Zarnecki, A; Zdzienicka, A, 2000) |
| " For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome." | 8.98 | Uric Acid as a Cause of the Metabolic Syndrome. ( Jensen, T; Johnson, RJ; King, C; Lanaspa, MA; Sánchez-Lozada, LG; Tolan, DR, 2018) |
| "Uric acid nephrolithiasis (UAN) is an increasingly common disease in ethnically diverse populations and constitutes about 10% of all kidney stones." | 8.98 | Metabolic syndrome and uric acid nephrolithiasis: insulin resistance in focus. ( Badalamenti, S; Dauriz, M; Ferraro, PM; Gambaro, G; Spatola, L, 2018) |
| " Multiple linear regression models were used to correlate changes in BCKAs, glutamate/glutamine and uric acid with changes in weight and insulin sensitivity as assessed by HOMA-IR, adiponectin and the ratio of triglyceride (TG) to HDL." | 8.31 | Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity. ( Armstrong, S; Bain, JR; Balikcioglu, M; Freemark, M; Gumus Balikcioglu, P; Ilkayeva, O; Jachthuber Trub, C; Muehlbauer, M; White, PJ, 2023) |
| " Measurements of anthropometric parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C reactive protein, uric acid, resistin and prevalence of Metabolic Syndrome were determined." | 8.31 | Resistin/uric acid index as a marker of metabolic syndrome in females with obesity. ( de Luis, D; Izaola, O; Primo, D, 2023) |
| " The aim of this study was to investigate whether autoimmune thyroiditis determines cardiometabolic effects of cabergoline." | 8.31 | Autoimmune Thyroiditis Attenuates Cardiometabolic Effects of Cabergoline in Young Women With Hyperprolactinemia. ( Kowalcze, K; Krysiak, R; Okopień, B, 2023) |
| "The relationship between diabetes mellitus (DM) and high serum uric acid is complex and controversial." | 8.31 | Uric acid and diabetes mellitus: an update. ( Iquebal, MA; Jaiswal, S; Rai, PK; Singh, R; Singh, SK, 2023) |
| "To investigate the value of C-peptide-based insulin resistance index in evaluating the correlation between insulin resistance and serum uric acid (Ua) level in subjects undergoing health examination." | 8.31 | [Value of C-peptide-based insulin resistance index for evaluating correlation between insulin resistance and serum uric acid level in individuals undergoing health examination]. ( Fang, F; Fu, X; Gu, Z; Li, H; Liu, X; Sun, B; Sun, J; Wang, N; Wang, W; Yan, S, 2023) |
| "Serum uric acid (SUA) has been associated with cardiometabolic conditions such as insulin resistance (IR) and visceral adipose tissue (VAT) accumulation." | 8.12 | Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue. ( Aguilar Salinas, CA; Almeda-Valdés, P; Antonio-Villa, NE; Bello-Chavolla, OY; Fermín-Martínez, CA; Fernández-Chirino, L; Gómez-Velasco, D; Guerra, EC; Márquez-Salinas, A; Rojas, R; Vargas-Vázquez, A; Viveros-Ruiz, TL, 2022) |
| "Adipose tissue plays a crucial role in serum uric acid (UA) metabolism, but the relative contribution of adipose tissue insulin resistance (IR) to serum UA levels and hyperuricemia have not explicitly been illustrated." | 8.12 | Adipose Tissue Insulin Resistance Is Positively Associated With Serum Uric Acid Levels and Hyperuricemia in Northern Chinese Adults. ( An, Y; Bian, N; Chang, X; Leng, S; Liu, J; Sun, H; Wang, G, 2022) |
| "To investigate the relationship between fibrinogen-like protein 1 (FGL-1) concentrations and various metabolic characteristics in patients with polycystic ovary syndrome (PCOS) and explore whether FGL-1 could be a predictive biomarker for PCOS." | 8.12 | Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study. ( Cai, M; Chen, D; Dilimulati, D; Gao, X; Qu, S; Shao, X; Sun, H; You, H; Zhang, M; Zhang, Y, 2022) |
| " Additionally, anthropometric parameters (height, weight, BMI, waist circumference, hip circumference) such as lab data including lipid profile (triglycerides, HDL, LDL), liver function parameters (ALT, AST), uric acid, glucose metabolism (fasting insulin and glucagon, HbA1c, glucose 120 min) and indices evaluating insulin resistance (HIRI, SPISE, HOMA-IR, WBISI) were measured." | 8.12 | Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease. ( Ahlström, H; Bergsten, P; Forslund, A; Kullberg, J; Manell, H; Mangge, H; Maruszczak, K; Mörwald, K; Pixner, T; Radzikowski, K; Schütz, S; Weghuber, D, 2022) |
| " Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), HOMA- β (%), lipids profile, monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), uric acid, gamma glutamyl transpeptidase (GGT), AST/ALT ratio and total bilirubin were assessed." | 8.12 | Association Between Total Bilirubin Levels and Cardio-Metabolic Risk Factors Related to Obesity. ( Asar, M; El-Eshmawy, MM; Elsehely, I; Mahsoub, N, 2022) |
| "Many studies have demonstrated that elevated serum uric acid independently increases the risk of developing hypertension." | 8.12 | Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study. ( Bai, Y; Bai, Z; Cheng, Z; Ding, J; Huang, P; Huang, W; Li, N; Liu, N; Wang, M; Wang, R; Wang, Y; Yang, J; Yin, C; Zhang, D; Zhang, R; Zheng, S, 2022) |
| "This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents." | 8.02 | Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents. ( Cai, W; Feng, Y; Mao, X; Niu, Y; Sheng, J; Tang, Q; Zhao, X, 2021) |
| "At the beginning of the study, both treatment arms differed in the degree of insulin resistance, calculated bioavailable testosterone, as well as in plasma levels of dehydroepiandrosterone sulfate, uric acid, hsCRP and 25-hydroxyvitamin D." | 8.02 | The impact of atorvastatin on cardiometabolic risk factors in brothers of women with polycystic ovary syndrome. ( Krysiak, R; Okopień, B; Szkróbka, W, 2021) |
| "This cross-sectional study investigates the association between insulin resistance (IR) and serum uric acid (sUA) and relative fat (RFM) and lean mass (RLM) profiles in children with chronic kidney disease (CKD)." | 8.02 | Association between relative fat mass, uric acid, and insulin resistance in children with chronic kidney disease. ( Christoforidis, A; Dotis, J; Karava, V; Kollios, K; Kondou, A; Liakopoulos, V; Papachristou, F; Printza, N; Tsioni, K, 2021) |
| "Circulating uric acid levels were associated with insulin resistance, but the causality is unclear." | 8.02 | Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis. ( Bao, W; Chen, L; Hu, X; Liu, L; Rong, S; Sun, T; Wang, Q, 2021) |
| "The relationships between uric acid (UA) and prediabetes is poorly explored in youth." | 8.02 | Uric acid, impaired fasting glucose and impaired glucose tolerance in youth with overweight and obesity. ( Baroni, MG; Campana, G; Chiesa, C; Del Giudice, EM; Di Bonito, P; Di Sessa, A; Licenziati, MR; Maffeis, C; Manco, M; Morandi, A; Pacifico, L; Valerio, G, 2021) |
| "To analyze the correlations between plasma coagulation factor VII (FVII), plasma plasminogen activator inhibitor-1 (PAI-1), uric acid, and insulin resistance (IR) and diabetic macroangiopathy (DMAP) in elderly patients with type 2 diabetes mellitus (T2DM)." | 8.02 | Analysis of the correlation between plasma coagulation factor VII, PAI-1, and uric acid with insulin resistance and macrovascular complications in elderly patients with type 2 diabetes. ( Li, L; Lu, Y; Ma, L; Shi, Z, 2021) |
| "The purpose of this study was to investigate the application value of serum 25(OH)D3, uric acid, triglyceride (TG), and homeostasis model assessment of insulin resistance (HOMA-IR) in male patients with hyperuricemia combined with hypogonadism." | 8.02 | The application value of serum 25(OH)D3, uric acid, triglyceride, and homeostasis model assessment of insulin resistance in male patients with hyperuricemia combined with hypogonadism. ( Chen, W; Wang, J; Yun, C; Zhang, Q, 2021) |
| "High uric acid (HUA) is associated with insulin resistance (IR) in cardiomyocytes." | 8.02 | Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo. ( Chen, Y; Jiao, Z; Li, Y; Li, Z; Xie, Y, 2021) |
| " The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)." | 8.02 | Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021) |
| "There was a significant linear trend of increasing systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol, low-density lipoprotein cholesterol (LDLc), uric acid, insulin levels, and HOMA-IR index values corresponding with overweight and obese groups; however, high-density lipoprotein cholesterol (HDLc) levels decreased with increasing obesity." | 8.02 | High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle? ( de Araujo, PX; de Carvalho, BS; Franco, MDC; Thomazini, F, 2021) |
| "To evaluate the impact of changes in uric acid over 2 years on changes in insulin sensitivity, beta-cell function, and glycemia in women with and without recent gestational diabetes (GDM), a model of the early natural history of T2DM." | 7.96 | Changes Over Time in Uric Acid in Relation to Changes in Insulin Sensitivity, Beta-Cell Function, and Glycemia. ( Connelly, PW; Hanley, AJ; Retnakaran, R; Volpe, A; Ye, C; Zinman, B, 2020) |
| "We aimed to investigate resistin expression in penile tissue in the presence of insulin resistance (IR) and the effect of Boldine treatment on erectile functions in the metabolic syndrome (MetS) rat model." | 7.96 | The role of resistin on metabolic syndrome-induced erectile dysfunction and the possible therapeutic effect of Boldine. ( Atabey, N; Dayar, E; Demir, O; Durmus, N; Gidener, S; Kahraman, E; Kara, E; Yetik Anacak, G, 2020) |
| "We investigated the association between serum uric acid (SUA) levels and insulin secretion and resistance in prediabetes patients, which is currently unclear." | 7.91 | The Association between Serum Uric Acid Levels and Insulin Resistance and Secretion in Prediabetes Mellitus: A Cross-Sectional Study. ( An, Z; He, H; Huang, H; Wu, Y; Yu, K; Zhang, M, 2019) |
| "Conflicting results suggest a link between serum uric acid (SUA), inflammation and glucose/insulin homeostasis; however, the role of adiposity in this relationship is not clear." | 7.88 | The link between insulin resistance parameters and serum uric acid is mediated by adiposity. ( Banach, M; Katsiki, N; Mazidi, M; Mikhailidis, DP, 2018) |
| " Patients with metabolic syndrome (MS) have higher values of homocysteine." | 7.88 | Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score. ( Colak, E; Dimitrijevic-Sreckovic, V; Gacic, J; Janeski, H; Janeski, N; Mrdovic, I; Soldatovic, I; Srećković, B; Sumarac-Dumanovic, M, 2018) |
| " Both Diosmin and Crocin improved insulin resistance, decreased blood pressure, uric acid, lipoproteins and blocked diabetic nephropathy as indicated by reduction of albumin excretion rate and albumin/creatinine ratio." | 7.88 | Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation. ( El Fayoumi, HM; El-Fawal, R; Mahmoud, MF, 2018) |
| "Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS)." | 7.85 | Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. ( Aronici, M; Bellone, S; Bona, G; Castagno, M; Di Mario, C; Genoni, G; Grossini, E; Martelli, M; Menegon, V; Monzani, A; Prodam, F; Ricotti, R; Secco, GG; Sonzini, M, 2017) |
| "Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome." | 7.85 | Circulating Levels of Uric Acid and Risk for Metabolic Syndrome. ( Durán-Salgado, MB; Garro-Almendaro, AK; Huerta-Ramírez, S; Lozano-Nuevo, JJ; Morales-López, H; Rubio-Guerra, AF; Vargas-Ayala, G, 2017) |
| "We aimed to investigate the effects of febuxostat on IR and the expression of high-sensitivity C-reactive protein (hs-CRP) in patients with primary gout." | 7.85 | Effects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout. ( Li, Y; Lu, Y; Meng, J; Yuan, X, 2017) |
| "Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD)." | 7.83 | Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome. ( Demirci, F; Demirustu, C; Ergun, B; Kebapci, N; Ozcelik, E; Temel, HE; Uslu, S, 2016) |
| "This study examined the relationship between serum levels of uric acid and insulin resistance and metabolic syndrome in nondiabetic patients with schizophrenia." | 7.83 | Relationship between serum uric acid level and cardiometabolic risks in nondiabetic patients with schizophrenia. ( Cimpeanu, C; Fan, X; Harrington, A; Rajan, S; Song, X; Zalpuri, I, 2016) |
| "We initially analyzed the impact of uric acid on the development of hepatic steatosis and insulin resistance in mice and in two cell models, HepG2 and L02." | 7.83 | Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. ( He, H; Li, D; Li, Y; Lin, Y; Liu, X; Lu, C; Sang, J; Wan, X; Xu, C; Yu, C, 2016) |
| "Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated." | 7.83 | Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. ( Abe, M; Katoh, T; Kawamoto, R; Kohara, K; Kumagi, T; Ninomiya, D, 2016) |
| "Inefficient renal excretion of uric acid is the main pathophysiological mechanism for hyperuricemia in gout patients." | 7.81 | Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients. ( Aniel-Quiroga, MA; Chinchilla, SP; Erauskin, GG; Herrero-Beites, AM; Merriman, T; Perez-Ruiz, F, 2015) |
| "We tested the hypothesis that uric acid levels are higher in subjects with schizophrenia treated with clozapine than in healthy control and they correlate with anthropometric measurements, laboratory tests and results of bioimpedance analysis of body composition." | 7.81 | Uric acid levels in patients with schizophrenia on clozapine monotherapy. ( Kłoszewska, I; Wysokiński, A, 2015) |
| " Linear regression was used to evaluate associations between uric acid and clinical and laboratory findings associated with metabolic syndrome." | 7.81 | [Metabolic complications of obesity during adolescence, particularly regarding elevated uric acid levels]. ( Almási, A; Barkai, L; Fehér, V; Kiss-Tóth, E; Ságodi, L, 2015) |
| "To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity." | 7.81 | [The role of uric acid in the insulin resistance in children and adolescents with obesity]. ( Almeida, GG; Belo, VA; Cunha, MB; de Miranda, JA; dos Santos, JE; Lanna, CM; Martins, RI; Mourão-Júnior, CA, 2015) |
| " We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxidant, affects the following: 1) systemic (plasma and saliva) nonenzymatic antioxidant capacity (NEAC); 2) markers of systemic (urinary 8-iso-prostaglandin-F2α) and muscle (carbonylated protein content) oxidative stress; and 3) whole-body insulin sensitivity (percentage increase in glucose uptake during a hyperinsulinemic-euglycemic clamp procedure)." | 7.80 | Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. ( Colic Baric, I; Fabbrini, E; Hazen, SL; Klein, S; Serafini, M, 2014) |
| " Despite evidence of uric acid-induced endothelial dysfunction, a relationship with insulin resistance has not been clearly established." | 7.80 | Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. ( Choi, YJ; Hien, TT; Kang, DH; Kang, KW; Kim, KC; Lee, BH; Lee, J; Lee, KY; Lee, MY; Lee, SM; Yoon, Y, 2014) |
| "To investigate the relationship among serum uric acid levels and metabolic syndrome." | 7.80 | Serum uric acid levels and metabolic syndrome. ( Ciarla, S; Ferri, C; Giorgini, P; Necozione, S; Properzi, G; Striuli, R; Struglia, M, 2014) |
| "This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension." | 7.80 | Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension. ( Chen, B; Deng, W; Zhang, J; Zhang, Y, 2014) |
| " Fructose administration resulted in significant increase in body weight, elevations of blood glucose, serum insulin, cholesterol, triglycerides, advanced glycation end products (AGEs), uric acid levels, insulin resistance index and blood pressure compared to control rats." | 7.80 | Ursodeoxycholic acid ameliorates fructose-induced metabolic syndrome in rats. ( Elshazly, SM; Mahmoud, AA, 2014) |
| "High uric acid (UA) levels and metabolic syndrome (MS) are risk factors for atherosclerotic diseases." | 7.79 | Relationship between uric acid and arterial stiffness in the elderly with metabolic syndrome components. ( Sun, N; Tian, JL; Wang, H; Zhang, Y, 2013) |
| "Experimental and observational studies suggest a role for uric acid in non-alcoholic fatty liver disease (NAFLD)." | 7.79 | Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. ( Chonchol, M; Jalal, DI; Johnson, RJ; McFann, K; Sirota, JC; Targher, G, 2013) |
| " Since low urine pH is the main risk factor for uric acid urolithiasis (UAU), UAU may be regarded as a renal manifestation of the MS." | 7.78 | Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. ( Schubert, G; Strohmaier, WL; Wrobel, BM, 2012) |
| " Our aims were to determine the relationship between uric acid and insulin resistance and to define the optimal uric acid cutoff to identify insulin resistance in women." | 7.78 | Optimal uric acid threshold to identify insulin resistance in healthy women. ( Balbín, E; Carbajal, HA; Dulbecco, CA; Espeche, WG; March, CE; Marillet, AG; Salazar, MR, 2012) |
| "In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats." | 7.78 | Melatonin improves metabolic syndrome induced by high fructose intake in rats. ( Kitagawa, A; Ohashi, K; Ohta, Y, 2012) |
| " At the end of the feeding schedule, Dia group had insulin resistance along with increased blood glucose, triglyceride, uric acid and nitric oxide (NO) levels." | 7.78 | Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. ( Bagul, PK; Banerjee, SK; Bastia, T; Chakravarty, S; Madhusudana, K; Matapally, S; Middela, H; Padiya, R; Reddy, BR, 2012) |
| "Uric acid, the levels of which have been shown to increase after menopause, has been associated with metabolic syndrome." | 7.77 | Relationship between uric acid and metabolic syndrome according to menopausal status. ( Ahn, KH; Cho, GJ; Hur, JY; Kim, SH; Kim, T; Kim, YT; Lee, HJ; Park, HT; Shin, JH; Yi, KW, 2011) |
| "This study aimed to evaluate the association of serum inflammatory markers (C-reactive protein (CRP) and uric acid (UA)), magnesium and other CVD risk factors with insulin resistance (IR) among Chinese postmenopausal women with prediabetes." | 7.77 | The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes. ( Ho, SC; Liu, ZM, 2011) |
| "Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance." | 7.76 | Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. ( Lee, HR; Lee, JH; Lee, YJ; Shim, JY; Shin, YH, 2010) |
| " Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased." | 7.76 | Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010) |
| "Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established." | 7.76 | Clinical value of serum uric Acid in patients with suspected coronary artery disease. ( Kim, EJ; Kim, JW; Kim, SH; Lim, HE; Park, CG; Rha, SW; Seo, HS, 2010) |
| "Uric acid is heritable and associated with hypertension and insulin resistance." | 7.75 | Genome-wide linkage analysis for uric acid in families enriched for hypertension. ( Asmann, Y; Boerwinkle, E; Fridley, BL; Hunt, SC; Mosley, TH; Pankow, JS; Rule, AD; Turner, ST, 2009) |
| "The aim of this prospective study was to evaluate results of metformin (MF) therapy during 1 year of uric acid (UA) metabolism and the clinical course of gout with insulin resistance (IR)." | 7.75 | [Effect of metformin on the clinical course of gout and insulin resistance]. ( Aleksandrova, EN; Barskova, VG; Eliseev, MS; Kudaeva, FM; Nasonov, EL; Nasonova, VA; Volkov, AV, 2009) |
| "We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth." | 7.75 | Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women. ( Catov, J; Laughon, SK; Roberts, JM, 2009) |
| "The aim of this study is to investigate the respective associations of alanine aminotransferase (ALT), white blood cell (WBC) count, and uric acid with metabolic syndrome and compare the magnitude in their association with metabolic syndrome, using modified Adult Treatment Panel III (ATP III) and its components." | 7.74 | Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults. ( Kang, YH; Kim, IJ; Kim, YK; Min, HG; Son, SM, 2008) |
| "This study investigates the impact of uric acid (UA) on the risk factors associated with metabolic syndrome." | 7.74 | Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid. ( Chang, HY; Chiou, WK; Lin, JD; Liu, FH; Weng, HF, 2007) |
| "We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects." | 7.74 | Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. ( Bonadonna, RC; Bonora, E; Capaldo, B; De Mattia, G; Del Prato, S; Frittitta, L; Frontoni, S; Leonetti, F; Luzi, L; Marchesini, G; Marini, MA; Natali, A; Paolisso, G; Perin, PC; Piatti, PM; Pujia, A; Solini, A; Vettor, R, 2008) |
| "To assess the effect of the serum uric acid (UA) on insulin resistance (IR)." | 7.74 | [A prospective study on relationship between blood uric acid levels, insulin sensitivity and insulin resistance]. ( Liu, J; Liu, S; Wang, M; Wang, W; Zhao, D, 2007) |
| "To evaluate haemoglobin A1c (HbA1c), fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels in a nationally representative sample of men and women." | 7.74 | Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey. ( Choi, HK; Ford, ES, 2008) |
| "To assess the correlation between serum uric acid and insulin resistance in natural population of Beijing." | 7.74 | [Correlation between serum uric acid and insulin resistance]. ( Li, GW; Liu, J; Liu, S; Qin, LP; Wang, M; Wang, W; Zhao, D; Zhou, GH, 2007) |
| "The purpose of this study was to assess a possible correlation between insulin resistance and uric acid levels in gestational hypertension (GH) and preeclampsia." | 7.73 | Elevated serum uric acid levels in gestational hypertension are correlated with insulin resistance. ( Cohen, O; Homko, CJ; Schiff, E; Sivan, E; Weisz, B, 2005) |
| "The levels of the liporegulatory hormone leptin are increased in obesity, which contributes to the metabolic syndrome; the latter is associated with elevated cardiovascular risk and morbidity." | 7.73 | Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans. ( Chraibi, A; Israili, ZH; Lyoussi, B; Mguil, M; Ragala, MA, 2005) |
| " The present study examined a Korean adult population with respect to the relationships between serum uric acid concentrations and hypertension, insulin resistance, and the risk factors of metabolic syndrome." | 7.73 | Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. ( Kang, JH; Keum, DG; Kim, BJ; Kim, BS; Kim, H; Kim, SW; Lee, MH; Lee, WY; Park, JR; Rhee, EJ; Ryu, SH; Shin, HS; Sung, KC; Yoo, TW, 2005) |
| "This study was performed to test whether plasma homocysteine concentrations are related to insulin resistance in healthy premenopausal women." | 7.73 | Insulin resistance is not related to plasma homocysteine concentration in healthy premenapausal women. ( Bekpinar, S; Orhan, Y; Tanrikulu-Kiliç, F; Unlüçerçi, Y, 2006) |
| "Body weight and BP decreased significantly in the diet group but not in the troglitazone group at the end of the intervention periods." | 7.71 | Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. ( Kamide, K; Kawano, Y; Minami, J; Tsunoda, S, 2002) |
| "To assess the impacts of insulin resistance and renal function on plasma total homocysteine (tHcy) levels in patients with type 2 diabetes with a wide range of nephropathy." | 7.71 | Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes. ( Emoto, M; Inaba, M; Ishimura, E; Kanda, H; Kawagishi, T; Komatsu, M; Mori, K; Nishizawa, Y; Okuno, Y; Shoji, T; Tahara, H, 2001) |
| " Mean values of alanine transaminase, gammaglutamyltranspeptidase, triglycerides, uric acid, fasting and log insulin, transferrin percent saturation and ferritin were significantly higher in the patients, while transferrin and quantitative insulin sensitivity check index, a quantitative insulin sensitivity index, were lower." | 7.71 | Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study. ( Bagni, A; Bertolotti, M; Borsatti, A; Carulli, N; Ganazzi, D; Leonardi, F; Lonardo, A; Loria, P; Neri, P; Pulvirenti, M; Verrone, AM, 2002) |
| "Patients with LBS demonstrated similar metabolic features in terms of insulin sensitivity and hyperleptinemia as patients with "simple" truncal obesity." | 7.71 | Insulin resistance, hyperleptinemia, and obstructive sleep apnea in Launois-Bensaude syndrome. ( Ficker, JH; Fuchs, FS; Hahn, EG; Harsch, IA; Konturek, PC; Lohmann, T; Schahin, SP, 2002) |
| "To determine whether fasting serum uric acid is associated with the insulin sensitivity index or with other anthropometric, metabolic or environmental features of the insulin resistance syndrome in a population-based sample of young healthy Caucasians." | 7.70 | Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-based sample of 380 young healthy Caucasians. ( Borch-Johnsen, K; Clausen, JO; Ibsen, H; Pedersen, O, 1998) |
| "Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease." | 7.69 | Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. ( Landsberg, L; Lee, J; Sparrow, D; Vokonas, PS; Weiss, ST, 1995) |
| "To examine the relationships of serum uric acid concentration with several risk factors of cardiovascular diseases (CVD)." | 7.69 | Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study. ( Bonora, E; Branzi, P; Cacciatori, V; Muggeo, M; Saggiani, F; Santi, L; Targher, G; Tosi, F; Travia, D; Zenere, MB; Zenti, MG, 1996) |
| "Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance." | 7.69 | Normal serum uric acid concentrations in women with polycystic ovary syndrome. ( Anttila, L; Irjala, K; Penttilä, T; Rouru, J, 1996) |
| "There is an inverse relationship between serum uric acid concentrations and measures of functional capacity in patients with cardiac failure." | 7.69 | Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure. ( Anker, S; Chua, TP; Coats, AJ; Godsland, IF; Leyva, F; Stevenson, JC; Swan, JW; Wingrove, CS, 1997) |
| "The aim of the present study was to evaluate the relationship of C-peptide and the C-peptide/bloodsugar ratio with clinical/biochemical variables presenting a well-known association with insulin resistance in NIDDM patients in acceptable control, obtained without the use of exogenous insulin." | 7.69 | Relationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients. ( Acosta, D; Astorga, R; García de Pesquera, F; Losada, F; Morales, F; Pumar, A; Relimpio, F, 1997) |
| "Hyperuricemia is a metabolic disease caused by purine nucleotide metabolism disorder." | 7.01 | Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond. ( Cheng, J; Koyama, H; Yamamoto, T; Yu, W, 2023) |
| "Insulin resistance was calculated with the homeostasis model assessment." | 6.73 | Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance. ( Almaraz, MC; Cardona, F; Cardona, I; Collantes, E; Garrido-Sánchez, L; Rojo-Martínez, G; Soriguer, F; Tinahones, FJ; Vázquez-Mellado, J, 2008) |
| "The uric acid concentration was significantly higher in postmenopausal versus premenopausal women." | 6.69 | The effect of menopause on serum uric acid levels in non-obese healthy women. ( Stevenson, JC; Walton, C; Wingrove, CS, 1998) |
| "In contrast, hyperinsulinemia caused a significant decrease in the urinary excretion of uric acid (2." | 6.68 | Effect of insulin on renal sodium and uric acid handling in essential hypertension. ( Bianchi, S; Bigazzi, R; Ciociaro, D; Ferrannini, E; Frascerra, S; Galvan, AQ; Muscelli, E; Natali, A; Sironi, AM, 1996) |
| "Nonalcoholic fatty liver disease (NAFLD) is a major, worldwide public health problem." | 6.53 | Serum uric acid: a new therapeutic target for nonalcoholic fatty liver disease. ( Braddock, M; Liu, WY; Lu, QD; Shi, KQ; Song, D; Sun, DQ; Wu, SJ; Zheng, MH; Zhu, GQ, 2016) |
| "Hyperuricemia is a prevalent finding in patients presenting metabolic syndrome, although its clinical meaning is still controversial and often underestimated." | 6.46 | Uric acid as a factor in the metabolic syndrome. ( Batista, MC; Borges, RL; Ribeiro, AB; Zanella, MT, 2010) |
| "Uric acid is a major product of purine metabolism in humans." | 6.46 | Uric acid and the development of hypertension. ( Hwu, CM; Lin, KH, 2010) |
| "Uric acid may increase as a result of pathophysiological processes such as impaired renal sodium handling but may also contribute to renal and vascular damage, particularly endothelial dysfunction." | 6.43 | Uric acid and hypertension. ( Schachter, M, 2005) |
| "Both hyperprolactinemia and early-onset androgenic alopecia are associated with increased cardiometabolic risk." | 5.91 | Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia. ( Basiak, M; Krysiak, R; Okopień, B; Szkróbka, W, 2023) |
| "Phthalimide derivatives have been extensively researched with various biological actions." | 5.72 | Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance. ( da Rocha, IG; da Silva Júnior, JG; da Silva Neto, JC; de Araújo, HDA; de Menezes Lima, VL; de Oliveira Assis, SP; Oliveira, RN, 2022) |
| "Insulin resistance was assessed by the homeostatic model assessment (HOMA) index." | 5.56 | Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance. ( Andreozzi, F; Armentaro, G; Cassano, V; Crescibene, D; Hribal, ML; Magurno, M; Maio, R; Miceli, S; Pelaia, C; Perticone, F; Perticone, M; Sciacqua, A; Sesti, G; Toscani, A, 2020) |
| "As uric acid levels increase there is a relevant clustering of metabolic risk factors, whereas elevated blood pressure is the risk factor less frequently present." | 5.48 | Uric acid is linked to cardiometabolic risk factors in overweight and obese youths. ( Alvarez-Pitti, J; Borghi, C; Lurbe, E; Redon, J; Redon, P; Torro, MI, 2018) |
| "The prevalence rates of NAFLD were 71." | 5.43 | Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults. ( Chen, N; He, CM; Li, X; Li, Z; Liu, CQ; Liu, S; Liu, Y; Shi, X; Wang, D; Yan, B; Yang, S; Zeng, X, 2016) |
| "Insulin resistance was determined by the homeostasis model assessment (HOMA-IR)." | 5.35 | Uric acid: a surrogate of insulin resistance in older women. ( Chen, LK; Chiou, ST; Hwang, SJ; Lai, HY; Lin, MH, 2008) |
| "Patients treated with ALA at T1 and T2 showed a significant reduction in serum glucose, insulin, homeostatic model assessment-insulin resistance, and serum uric acid (P = 0." | 5.34 | α-lipoic acid in patients with autosomal dominant polycystic kidney disease. ( Amabile, MI; Ansuini, M; Carta, M; Cianci, R; D'Ambrosio, V; Galani, A; Lai, S; Letizia, C; Mazzaferro, S; Mitterhofer, AP; Molfino, A; Muscaritoli, M; Pasquali, M; Petramala, L; Ramaccini, C, 2020) |
| "Hyperuricemia is associated with cardiovascular risk." | 5.33 | Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity. ( Fu, Y; Katsuya, T; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2005) |
| "Acute hyperinsulinemia was associated with higher urinary pH (6." | 5.32 | The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. ( Abate, N; Cabo-Chan, AV; Chandalia, M; Moe, OW; Sakhaee, K, 2004) |
| "Increased blood lactate or uric acid (UA) levels are associated with an increased risk of metabolic syndrome (MS)." | 5.30 | Interaction Between Lactate and Uric Acid is Associated With a Higher Prevalence of Metabolic Syndrome: A Community-Based Study. ( Li, F; Pan, H; Ren, M; Wu, M; Xu, M; Yan, D; Zhang, J, 2019) |
| "In women, abdominal obesity measures were associated with glycated hemoglobin levels (HbA1c), fasting serum glucose, insulin, triglycerides (TG), total cholesterol (Chol), high-density lipoprotein (HDL), and uric acid levels as well as Chol/HDL ratio and homeostatic model assessment of insulin resistance (HOMA-IR) independently of age and BMI." | 5.27 | Sagittal Abdominal Diameter does not Predict Metabolic Traits Better than Waist Circumference-Related Measures of Abdominal Obesity in Obese Subjects. ( Ernst, B; Keppler, R; Schmid, SM; Schultes, B; Thurnheer, M; Wilms, B; Zazai, R, 2018) |
| " No significant changes were observed in fasting plasma glucose, quantitative insulin sensitivity check index, hs-CRP, superoxide dismutase, catalase and uric acid in the RS2 group as compared with the control group." | 5.22 | The Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial. ( Dehghan, P; Farhangi, MA; Gargari, BP; Karimi, P; Pouraghaei, M; Sarmadi, B; Zare Javid, A, 2016) |
| "Elevated plasma uric acid concentration is a risk factor for gout, insulin resistance and type 2 diabetes." | 5.22 | Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial. ( Shi, Y; Williamson, G, 2016) |
| "To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents." | 5.22 | Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance. ( Chan, TF; Huang, HL; Lee, CH; Lee, CY; Lin, WT; Tsai, S; Wang, TN; Wu, PW; Yang, YC, 2016) |
| "Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia." | 5.20 | Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. ( Afsar, B; ALanaspa, M; Bakan, A; Elcioglu, OC; Erek, A; Johnson, RJ; Kanbay, M; Kostek, O; Mutlu, HH; Odabas, AR; Ozkok, A; Semerci, A; Sharma, S; Smits, G; Takir, M; Telci, O, 2015) |
| " Weight, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) index as well as serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), insulin, total and direct bilirubin, fasting blood sugar (FBS), glycated hemoglobin (HbA1c), uric acid, albumin and lipid profile were evaluated at baseline and at the end of trial." | 5.16 | Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial. ( Beiraghdar, F; Ghamarchehreh, ME; Jalalian, HR; Panahi, Y; Sahebkar, A; Zare, R, 2012) |
| " Serum insulin, glucose, C-reactive protein (CRP), lipids, uric acid, YKL-40 and blood pressure were measured and insulin sensitivity was calculated (HOMA) at the beginning and end of each study phase." | 5.14 | Effect of moxonidine and amlodipine on serum YKL-40, plasma lipids and insulin sensitivity in insulin-resistant hypertensive patients-a randomized, crossover trial. ( Majer, J; Masajtis-Zagajewska, A; Nowicki, M, 2010) |
| "This meta-analysis aimed to investigate whether uric acid lowering treatment can improve β-cell function and insulin sensitivity." | 5.12 | Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials. ( Ma, G; Wang, T; Zong, Q, 2021) |
| "To evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR)." | 5.11 | [Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)]. ( Barskova, VG; Eliseev, MS; Iakunina, IA; Il'inykh, EV; Kudaeva, FM; Nasonov, EL; Tsapina, TN; Volkov, AV; Zilov, AV, 2005) |
| " The aim of this study was to evaluate the effects of hyperprolactinemia and bromocriptine (Brc) treatment on endothelial function, insulin sensitivity and inflammatory markers in pre-menopausal women." | 5.10 | Endothelial function, insulin sensitivity and inflammatory markers in hyperprolactinemic pre-menopausal women. ( Akalin, S; Akpinar, I; Deyneli, O; Gözü, H; Haklar, G; Sezgin, O; Yavuz, D; Yildiz, E, 2003) |
| "These favourable effects of comicronised fenofibrate both on lipid and non lipid parameters, including insulin sensitivity, may confer to this product a particular interest in the treatment of patients with polymetabolic syndrome X." | 5.09 | Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X. ( Blane, G; Idzior-Walus, B; Kawalec, E; Rostworowski, W; Sieradzki, J; Wójcik, J; Zarnecki, A; Zdzienicka, A, 2000) |
| "We performed the present study to determine the degree of visceral fat accumulation and incidence of visceral fat obesity in 138 gout patients who were classified as overexcretion type (n = 53) and underexcretion type (n = 85) by their levels of uric acid clearance and urinary uric acid excretion." | 5.09 | Increased visceral fat accumulation further aggravates the risks of insulin resistance in gout. ( Hada, T; Moriwaki, Y; Takahashi, S; Tsutsumi, Z; Yamakita , J; Yamamoto, T, 2001) |
| "We included randomized controlled trials (RCTs) investigating the isocaloric effect of substituting dietary sugars (fructose, glucose, sucrose) with other sugars or starch on cardiometabolic risk markers, including LDL cholesterol, triacylglycerol (TG), fasting glucose (FG), glycated hemoglobin (HbA1c), insulin resistance (HOMA-IR), uric acid, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST), and liver fat content." | 5.05 | Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions. ( Buyken, AE; Hoffmann, G; Neuenschwander, M; Schlesinger, S; Schwingshackl, L, 2020) |
| " In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age." | 5.05 | Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age. ( Esposito, P; Garibotto, G; Leoncini, G; Pontremoli, R; Russo, E; Viazzi, F, 2020) |
| " For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome." | 4.98 | Uric Acid as a Cause of the Metabolic Syndrome. ( Jensen, T; Johnson, RJ; King, C; Lanaspa, MA; Sánchez-Lozada, LG; Tolan, DR, 2018) |
| "Uric acid nephrolithiasis (UAN) is an increasingly common disease in ethnically diverse populations and constitutes about 10% of all kidney stones." | 4.98 | Metabolic syndrome and uric acid nephrolithiasis: insulin resistance in focus. ( Badalamenti, S; Dauriz, M; Ferraro, PM; Gambaro, G; Spatola, L, 2018) |
| " The link between increased fructose consumption and increases in uric acid also has been confirmed as a potential risk factor for metabolic syndrome, and insulin resistance/hyperinsulinemia may be causally related to the development of hypertension." | 4.91 | Health implications of high-fructose intake and current research. ( de Lima, WG; Dornas, WC; Pedrosa, ML; Silva, ME, 2015) |
| "There is an increased prevalence of nephrolithiasis and an increase in the incidence of renal colic in patients with diabetes, obesity, hypertension and insulin resistance because of an increased frequency of uric acid crystallization." | 4.88 | Beware the low urine pH--the major cause of the increased prevalence of nephrolithiasis in the patient with type 2 diabetes. ( Bell, DS, 2012) |
| "A number of epidemiological studies have reported an association between serum uric acid levels and a wide variety of high-risk conditions including hypertension, insulin resistance, and kidney and cerebro-cardiovascular disease." | 4.88 | Cardiovascular and renal effects of hyperuricaemia and gout. ( Leoncini, G; Pontremoli, R; Viazzi, F, 2012) |
| "Uric acid has historically been viewed as a purine metabolic waste product excreted by the kidney and gut that is relatively unimportant other than its penchant to crystallize in joints to cause the disease gout." | 4.85 | Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? ( Benner, SA; Gabriela Sanchez-Lozada, L; Johnson, RJ; Mu, W; Nakagawa, T; Oliver, WJ; Rodriguez-Iturbe, B; Roncal, C; Sautin, YY, 2009) |
| "The level of serum uric acid in human has been increasing over the last decades, and correlates with an increase prevalence of renal disease and metabolic syndrome." | 4.84 | The conundrum of hyperuricemia, metabolic syndrome, and renal disease. ( Cirillo, P; Gersch, M; Johnson, RJ; Mu, W; Nakagawa, T; Roncal, C; Sánchez-Lozada, LG; Sato, W; Sautin, Y, 2008) |
| "Epidemiological and metabolic studies have indicated an association between uric acid nephrolithiasis and insulin resistance." | 4.82 | Novel insights into the pathogenesis of uric acid nephrolithiasis. ( Cameron, MA; Maalouf, NM; Moe, OW; Sakhaee, K, 2004) |
| "Epidemiological studies show that serum uric acid is positively associated with blood pressure levels and that serum uric acid is also a predictor of the development of hypertension in normotensive adults." | 4.79 | [Hypertension and hyperuricemia]. ( Hirai, A; Saitoh, Y, 1996) |
| " Multiple linear regression models were used to correlate changes in BCKAs, glutamate/glutamine and uric acid with changes in weight and insulin sensitivity as assessed by HOMA-IR, adiponectin and the ratio of triglyceride (TG) to HDL." | 4.31 | Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity. ( Armstrong, S; Bain, JR; Balikcioglu, M; Freemark, M; Gumus Balikcioglu, P; Ilkayeva, O; Jachthuber Trub, C; Muehlbauer, M; White, PJ, 2023) |
| " Measurements of anthropometric parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C reactive protein, uric acid, resistin and prevalence of Metabolic Syndrome were determined." | 4.31 | Resistin/uric acid index as a marker of metabolic syndrome in females with obesity. ( de Luis, D; Izaola, O; Primo, D, 2023) |
| "In conclusion, even in a short period of only 3 months, the administration of ARNI improved insulin resistance and consequently reduced the serum uric acid levels in patients with stable chronic heart failure." | 4.31 | Effects of angiotensin receptor-neprilysin inhibitor on insulin resistance in patients with heart failure. ( Inoue, Y; Kashiwagi, Y; Kawai, M; Kimura, H; Nagoshi, T; Ogawa, K; Oi, Y; Tanaka, Y; Yoshimura, M, 2023) |
| " The aim of this study was to investigate whether autoimmune thyroiditis determines cardiometabolic effects of cabergoline." | 4.31 | Autoimmune Thyroiditis Attenuates Cardiometabolic Effects of Cabergoline in Young Women With Hyperprolactinemia. ( Kowalcze, K; Krysiak, R; Okopień, B, 2023) |
| "The relationship between diabetes mellitus (DM) and high serum uric acid is complex and controversial." | 4.31 | Uric acid and diabetes mellitus: an update. ( Iquebal, MA; Jaiswal, S; Rai, PK; Singh, R; Singh, SK, 2023) |
| "To investigate the value of C-peptide-based insulin resistance index in evaluating the correlation between insulin resistance and serum uric acid (Ua) level in subjects undergoing health examination." | 4.31 | [Value of C-peptide-based insulin resistance index for evaluating correlation between insulin resistance and serum uric acid level in individuals undergoing health examination]. ( Fang, F; Fu, X; Gu, Z; Li, H; Liu, X; Sun, B; Sun, J; Wang, N; Wang, W; Yan, S, 2023) |
| "001), fibroblast growth factor 21, homeostasis model assessment of insulin resistance as an insulin resistance index and uric acid, and was negatively correlated with levels of high-density lipoprotein cholesterol and adiponectin." | 4.12 | Circulating level of fatty acid-binding protein 4 is an independent predictor of metabolic dysfunction-associated fatty liver disease in middle-aged and elderly individuals. ( Furuhashi, M; Higashiura, Y; Koyama, M; Ohnishi, H; Saitoh, S; Sakai, A; Shimamoto, K; Takahashi, S; Tanaka, M, 2022) |
| "Serum uric acid (SUA) has been associated with cardiometabolic conditions such as insulin resistance (IR) and visceral adipose tissue (VAT) accumulation." | 4.12 | Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue. ( Aguilar Salinas, CA; Almeda-Valdés, P; Antonio-Villa, NE; Bello-Chavolla, OY; Fermín-Martínez, CA; Fernández-Chirino, L; Gómez-Velasco, D; Guerra, EC; Márquez-Salinas, A; Rojas, R; Vargas-Vázquez, A; Viveros-Ruiz, TL, 2022) |
| "serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree." | 4.12 | Uric acid and uric acid/creatinine ratio and their correlations with the hemorheological determinants in subjects with subclinical carotid atherosclerosis. ( Amato, C; Brucculeri, S; Caimi, G; Carlisi, M; Lo Presti, R; Urso, C, 2022) |
| "Subjects with insulin resistance (n = 101) showed significantly lower nocturnal melatonin levels compared to those with unimpaired insulin secretion (p = 0." | 4.12 | Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity. ( Kalveram, L; Keller, T; Krude, H; Kühnen, P; Overberg, J; Wiegand, S, 2022) |
| " Indirect associations were mediated through the triglyceride-glucose (TyG) index (as an indicator of insulin resistance), mean arterial pressure (MAP), uric acid (UA), and total cholesterol (TC)." | 4.12 | The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia. ( Brozek, W; Concin, H; Fritz, J; Kerschbaum, J; Lhotta, K; Nagel, G; Ulmer, H; Zitt, E, 2022) |
| "Adipose tissue plays a crucial role in serum uric acid (UA) metabolism, but the relative contribution of adipose tissue insulin resistance (IR) to serum UA levels and hyperuricemia have not explicitly been illustrated." | 4.12 | Adipose Tissue Insulin Resistance Is Positively Associated With Serum Uric Acid Levels and Hyperuricemia in Northern Chinese Adults. ( An, Y; Bian, N; Chang, X; Leng, S; Liu, J; Sun, H; Wang, G, 2022) |
| "To investigate the relationship between fibrinogen-like protein 1 (FGL-1) concentrations and various metabolic characteristics in patients with polycystic ovary syndrome (PCOS) and explore whether FGL-1 could be a predictive biomarker for PCOS." | 4.12 | Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study. ( Cai, M; Chen, D; Dilimulati, D; Gao, X; Qu, S; Shao, X; Sun, H; You, H; Zhang, M; Zhang, Y, 2022) |
| "Hyperuricemia is a state in which the serum levels of uric acid (UA) are elevated." | 4.12 | Effects of rosuvastatin on serum glucose and insulin in hyperuricemic rats. ( Aili, A; Nuermaimaiti, B; Rehemu, N; Sun, H; Tuerxun, Z; Xilifu, D; Zhang, X, 2022) |
| " Additionally, anthropometric parameters (height, weight, BMI, waist circumference, hip circumference) such as lab data including lipid profile (triglycerides, HDL, LDL), liver function parameters (ALT, AST), uric acid, glucose metabolism (fasting insulin and glucagon, HbA1c, glucose 120 min) and indices evaluating insulin resistance (HIRI, SPISE, HOMA-IR, WBISI) were measured." | 4.12 | Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease. ( Ahlström, H; Bergsten, P; Forslund, A; Kullberg, J; Manell, H; Mangge, H; Maruszczak, K; Mörwald, K; Pixner, T; Radzikowski, K; Schütz, S; Weghuber, D, 2022) |
| " Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state in several peripheral tissues to promote the development of type 2 diabetes mellitus (T2DM)." | 4.12 | Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway ( Chen, B; Cheng, J; He, F; Koyama, H; Liu, W; Lu, J; Wang, M; Wang, Q; Wang, W; Xi, Y; Xu, C; Yamamoto, T; Yan, Y; Yu, L; Yu, W; Zhang, C; Zhao, H, 2022) |
| " Plasma lipids, insulin sensitivity, and levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine, and 25-hydroxyvitamin D were measured before and after 14-week treatment with atorvastatin (20 mg daily)." | 4.12 | Cabergoline-Induced Hypoprolactinemia May Attenuate Cardiometabolic Effects of Atorvastatin: A Pilot Study. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " We also tested whether the addition of an insulin resistance index (HOMA-index >90th percentile by sex and age) and the presence of hyperuricemia (serum uric acid >90th percentile by sex and age) to the definition of MUO better identified obese children with early cardiac damage." | 4.12 | Association of obesity phenotypes with left ventricular mass index and left ventricular hypertrophy in children and adolescents. ( Antolini, L; Genovesi, S; Giussani, M; Lieti, G; Montemerlo, M; Orlando, A; Parati, G; Patti, I; Tassistro, E, 2022) |
| " Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), HOMA- β (%), lipids profile, monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), uric acid, gamma glutamyl transpeptidase (GGT), AST/ALT ratio and total bilirubin were assessed." | 4.12 | Association Between Total Bilirubin Levels and Cardio-Metabolic Risk Factors Related to Obesity. ( Asar, M; El-Eshmawy, MM; Elsehely, I; Mahsoub, N, 2022) |
| "Many studies have demonstrated that elevated serum uric acid independently increases the risk of developing hypertension." | 4.12 | Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study. ( Bai, Y; Bai, Z; Cheng, Z; Ding, J; Huang, P; Huang, W; Li, N; Liu, N; Wang, M; Wang, R; Wang, Y; Yang, J; Yin, C; Zhang, D; Zhang, R; Zheng, S, 2022) |
| "This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents." | 4.02 | Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents. ( Cai, W; Feng, Y; Mao, X; Niu, Y; Sheng, J; Tang, Q; Zhao, X, 2021) |
| "At the beginning of the study, both treatment arms differed in the degree of insulin resistance, calculated bioavailable testosterone, as well as in plasma levels of dehydroepiandrosterone sulfate, uric acid, hsCRP and 25-hydroxyvitamin D." | 4.02 | The impact of atorvastatin on cardiometabolic risk factors in brothers of women with polycystic ovary syndrome. ( Krysiak, R; Okopień, B; Szkróbka, W, 2021) |
| "This cross-sectional study investigates the association between insulin resistance (IR) and serum uric acid (sUA) and relative fat (RFM) and lean mass (RLM) profiles in children with chronic kidney disease (CKD)." | 4.02 | Association between relative fat mass, uric acid, and insulin resistance in children with chronic kidney disease. ( Christoforidis, A; Dotis, J; Karava, V; Kollios, K; Kondou, A; Liakopoulos, V; Papachristou, F; Printza, N; Tsioni, K, 2021) |
| "Circulating uric acid levels were associated with insulin resistance, but the causality is unclear." | 4.02 | Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis. ( Bao, W; Chen, L; Hu, X; Liu, L; Rong, S; Sun, T; Wang, Q, 2021) |
| "The relationships between uric acid (UA) and prediabetes is poorly explored in youth." | 4.02 | Uric acid, impaired fasting glucose and impaired glucose tolerance in youth with overweight and obesity. ( Baroni, MG; Campana, G; Chiesa, C; Del Giudice, EM; Di Bonito, P; Di Sessa, A; Licenziati, MR; Maffeis, C; Manco, M; Morandi, A; Pacifico, L; Valerio, G, 2021) |
| "To analyze the correlations between plasma coagulation factor VII (FVII), plasma plasminogen activator inhibitor-1 (PAI-1), uric acid, and insulin resistance (IR) and diabetic macroangiopathy (DMAP) in elderly patients with type 2 diabetes mellitus (T2DM)." | 4.02 | Analysis of the correlation between plasma coagulation factor VII, PAI-1, and uric acid with insulin resistance and macrovascular complications in elderly patients with type 2 diabetes. ( Li, L; Lu, Y; Ma, L; Shi, Z, 2021) |
| "We sought to explore the relationship between commonly used measures of insulin sensitivity/resistance (homeostatic model assessment index, serum uric acid, and triglycerides to high-density lipoprotein cholesterol ratio) and left ventricular geometry in normotensive obese children." | 4.02 | Insulin resistance surrogates and left ventricular hypertrophy in normotensive obese children. ( Bjelakovic, B; Bjelakovic, L; Bratic, M; Ciric, M; Lukic, S; Pantelic, S; Saranac, L; Stankovic, S; Vukovic, V, 2021) |
| " The metabolic profile comprised the following components: waist circumference, glucose, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides, C-reactive protein, homeostatic model assessment index-insulin resistance (HOMA-IR), serum uric acid, systolic blood pressure, and diastolic blood pressure." | 4.02 | Phase angle association with metabolic profile in adults: A population-based study. ( Gabiatti, MP; Hansen, F; Longo, GZ; Martins, PC; Silva, DAS, 2021) |
| "The purpose of this study was to investigate the application value of serum 25(OH)D3, uric acid, triglyceride (TG), and homeostasis model assessment of insulin resistance (HOMA-IR) in male patients with hyperuricemia combined with hypogonadism." | 4.02 | The application value of serum 25(OH)D3, uric acid, triglyceride, and homeostasis model assessment of insulin resistance in male patients with hyperuricemia combined with hypogonadism. ( Chen, W; Wang, J; Yun, C; Zhang, Q, 2021) |
| "High uric acid (HUA) is associated with insulin resistance (IR) in cardiomyocytes." | 4.02 | Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo. ( Chen, Y; Jiao, Z; Li, Y; Li, Z; Xie, Y, 2021) |
| " The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)." | 4.02 | Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021) |
| "There was a significant linear trend of increasing systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol, low-density lipoprotein cholesterol (LDLc), uric acid, insulin levels, and HOMA-IR index values corresponding with overweight and obese groups; however, high-density lipoprotein cholesterol (HDLc) levels decreased with increasing obesity." | 4.02 | High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle? ( de Araujo, PX; de Carvalho, BS; Franco, MDC; Thomazini, F, 2021) |
| "Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0." | 3.96 | Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men. ( Cappuccio, FP; D'Elia, L; Galletti, F; Giaquinto, A; Iacone, R; Russo, O; Strazzullo, P, 2020) |
| "To evaluate the impact of changes in uric acid over 2 years on changes in insulin sensitivity, beta-cell function, and glycemia in women with and without recent gestational diabetes (GDM), a model of the early natural history of T2DM." | 3.96 | Changes Over Time in Uric Acid in Relation to Changes in Insulin Sensitivity, Beta-Cell Function, and Glycemia. ( Connelly, PW; Hanley, AJ; Retnakaran, R; Volpe, A; Ye, C; Zinman, B, 2020) |
| "We aimed to investigate resistin expression in penile tissue in the presence of insulin resistance (IR) and the effect of Boldine treatment on erectile functions in the metabolic syndrome (MetS) rat model." | 3.96 | The role of resistin on metabolic syndrome-induced erectile dysfunction and the possible therapeutic effect of Boldine. ( Atabey, N; Dayar, E; Demir, O; Durmus, N; Gidener, S; Kahraman, E; Kara, E; Yetik Anacak, G, 2020) |
| "The CMD were confirmed in the nicotine-exposed rats that exhibited lower body weight, insulin resistance, endothelial dysfunction, glucose intolerance, increased cardiac and renal TG, TG/HDL-cholesterol, UA, lactate, lipid peroxidation, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, LDH, CK, ADA and XO activities." | 3.96 | Sodium acetate prevents nicotine-induced cardiorenal dysmetabolism through uric acid/creatine kinase-dependent pathway. ( Adetunji, CO; Adeyanju, OA; Badmus, OO; Dibia, CL; Michael, OS; Oyewole, AL; Soetan, OA; Soladoye, AO, 2020) |
| " After adjustment for age, sex, body mass index (BMI), alanine aminotransferase (ALT), uric acid (UA), total bilirubin (TB), fasting plasma glucose (FPG) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), the OR for tertile 3 (OR = 1." | 3.96 | Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study. ( Lu, G; Miao, L; Xu, C; Xue, Z; Yang, S; Ye, M; Zhong, J; Zhou, X, 2020) |
| "To investigate the diagnostic role of combined salivary uric acid (UA), glucose and insulin levels to screen noninvasively for metabolic syndrome (MetS) and nonalcoholic fatty liver disease." | 3.91 | Salivary markers of hepato-metabolic comorbidities in pediatric obesity. ( Belmonte, F; Bisogno, A; Cavallo, P; Guercio Nuzio, S; Landolfi, A; Lausi, O; Marciano, F; Pierri, L; Troisi, J; Vajro, P, 2019) |
| " The fast food-type pattern was further associated with higher levels of C-reactive protein and uric acid and the unsaturated fatty acid pattern with reduced levels of insulin and homeostatic model assessment of insulin resistance (P < 0." | 3.91 | Dietary patterns and non-alcoholic fatty liver disease in a Greek case-control study. ( Borsa, D; Dedoussis, GV; Dimitriou, M; Kalafati, IP; Kokkinos, A; Revenas, K, 2019) |
| "We investigated the association between serum uric acid (SUA) levels and insulin secretion and resistance in prediabetes patients, which is currently unclear." | 3.91 | The Association between Serum Uric Acid Levels and Insulin Resistance and Secretion in Prediabetes Mellitus: A Cross-Sectional Study. ( An, Z; He, H; Huang, H; Wu, Y; Yu, K; Zhang, M, 2019) |
| " Glutamine (GLT) has been demonstrated to have a modulatory effect in MS and/or insulin resistance (IR)." | 3.91 | Glutamine confers renoprotection by normalizing lipid and glutathione content in insulin-resistant pregnant rats. ( Olaniyi, KS; Olatunji, LA, 2019) |
| "Conflicting results suggest a link between serum uric acid (SUA), inflammation and glucose/insulin homeostasis; however, the role of adiposity in this relationship is not clear." | 3.88 | The link between insulin resistance parameters and serum uric acid is mediated by adiposity. ( Banach, M; Katsiki, N; Mazidi, M; Mikhailidis, DP, 2018) |
| " (i) Insulin is considered to stimulate uric acid reabsorption via specific transporter and the effect of hyperuricaemia on the new-onset T2DM should be evaluated by considering insulin resistance." | 3.88 | Hyperuricaemia and type 2 diabetes mellitus. ( Kawada, T, 2018) |
| " Patients with metabolic syndrome (MS) have higher values of homocysteine." | 3.88 | Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score. ( Colak, E; Dimitrijevic-Sreckovic, V; Gacic, J; Janeski, H; Janeski, N; Mrdovic, I; Soldatovic, I; Srećković, B; Sumarac-Dumanovic, M, 2018) |
| "In severely obese patients, adiponectin gene expression in VAT is negatively correlated with serum levels of uric acid and is an independent determinant, together with anthropometric parameters of visceral obesity and serum adiponectin levels, of insulin resistance." | 3.88 | Adiponectin expression in visceral adiposity is an important determinant of insulin resistance in morbid obesity. ( Barbu, C; Buburuzan, L; Copaescu, C; Fica, S; Kevorkian, S; Martin, S; Sirbu, AE; Smeu, B, 2018) |
| " Both Diosmin and Crocin improved insulin resistance, decreased blood pressure, uric acid, lipoproteins and blocked diabetic nephropathy as indicated by reduction of albumin excretion rate and albumin/creatinine ratio." | 3.88 | Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation. ( El Fayoumi, HM; El-Fawal, R; Mahmoud, MF, 2018) |
| " Classical (fasting glucose, TGL, HDL, blood pressure) and non classical (insulin resistance [HOMA-IR], creatinine, AST, ALT, uric acid, fibrinogen, liver US and 24h BP profile) risk factors were compared between groups with and without MS." | 3.88 | Shall we diagnose metabolic syndrome in adolescents? ( Janus, D; Ruszała, A; Starzyk, JB; Szczudlik, E; Sztefko, K; Wójcik, M, 2018) |
| "Our study indicates LDJB-LSG is similar to LRYGB in the improvements of the body weight, blood glucose, insulin resistance, islet β cell function, blood lipid profile and serum uric acid, and thus LDJB-LSG is applicable in T2DM patients with 27." | 3.88 | Laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass in the treatment of type 2 diabetes mellitus of patients with body mass index higher than 27.5 kg/m2 but lower than 32.5 kg/m2. ( Fang, DH; Li, YX; Liu, TX, 2018) |
| "High-dose exenatide treatment can effectively reduce body mass of obese mice, but it has little difference when compared with dietary intervention in improving blood fat and liver steatosis." | 3.85 | [The Preliminary Investigation of GLP-1 Receptor Agonist on Liver Steatosis in Obese Mice]. ( An, ZM; He, H; Huang, HJ; Li, SQ; Li, SY; Liang, LB; Wang, X; Zhang, M, 2017) |
| "This study aimed to a) examine IR and β-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and β cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or without MetS and TUD, versus 46 healthy controls, and b) whether IR is associated with IO&NS biomarkers, including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), plasma advanced oxidation protein products (AOPP), C-reactive protein (CRP), haptoglobin (Hp) and uric acid." | 3.85 | Indices of insulin resistance and glucotoxicity are not associated with bipolar disorder or major depressive disorder, but are differently associated with inflammatory, oxidative and nitrosative biomarkers. ( Berk, M; Camargo, AEI; de Farias, CC; Dodd, S; Favaro Soares, J; Gastaldello Moreira, E; Higachi, L; Landucci Bonifácio, K; Maes, M; Nunes, SOV; Odebrecht Vargas, H; Sabbatini Barbosa, D, 2017) |
| "Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS)." | 3.85 | Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. ( Aronici, M; Bellone, S; Bona, G; Castagno, M; Di Mario, C; Genoni, G; Grossini, E; Martelli, M; Menegon, V; Monzani, A; Prodam, F; Ricotti, R; Secco, GG; Sonzini, M, 2017) |
| "Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome." | 3.85 | Circulating Levels of Uric Acid and Risk for Metabolic Syndrome. ( Durán-Salgado, MB; Garro-Almendaro, AK; Huerta-Ramírez, S; Lozano-Nuevo, JJ; Morales-López, H; Rubio-Guerra, AF; Vargas-Ayala, G, 2017) |
| "We aimed to investigate the effects of febuxostat on IR and the expression of high-sensitivity C-reactive protein (hs-CRP) in patients with primary gout." | 3.85 | Effects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout. ( Li, Y; Lu, Y; Meng, J; Yuan, X, 2017) |
| "Nonalcoholic fatty liver disease patients had significantly lower IGF-1 standard deviation score (IGF-1 SDS) and higher body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and uric acid levels than the control group." | 3.85 | Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents. ( Cheng, X; Hu, Y; Li, G; Liang, S; Song, R, 2017) |
| "Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD)." | 3.83 | Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome. ( Demirci, F; Demirustu, C; Ergun, B; Kebapci, N; Ozcelik, E; Temel, HE; Uslu, S, 2016) |
| " Uric acid levels, insulin resistance (homeostasis model assessment insulin resistance; HOMA-IR), C-reactive protein (CRP), triacylglycerol (TG), systolic blood pressure (SBP), abdominal fat and cIMT (both by ultrasound) were assessed." | 3.83 | Uric acid, carotid intima-media thickness and body composition in prepubertal children. ( Bassols, J; Carreras-Badosa, G; de Zegher, F; Díaz-Roldán, F; Ibáñez, L; López-Bermejo, A; Martínez-Calcerrada, JM; Osiniri, I; Prats-Puig, A; Riera-Pérez, E, 2016) |
| "This study examined the relationship between serum levels of uric acid and insulin resistance and metabolic syndrome in nondiabetic patients with schizophrenia." | 3.83 | Relationship between serum uric acid level and cardiometabolic risks in nondiabetic patients with schizophrenia. ( Cimpeanu, C; Fan, X; Harrington, A; Rajan, S; Song, X; Zalpuri, I, 2016) |
| "We initially analyzed the impact of uric acid on the development of hepatic steatosis and insulin resistance in mice and in two cell models, HepG2 and L02." | 3.83 | Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. ( He, H; Li, D; Li, Y; Lin, Y; Liu, X; Lu, C; Sang, J; Wan, X; Xu, C; Yu, C, 2016) |
| "Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated." | 3.83 | Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. ( Abe, M; Katoh, T; Kawamoto, R; Kohara, K; Kumagi, T; Ninomiya, D, 2016) |
| " Variables included were waist circumference (WC), glucose, high-density lipoprotein (HDL), triglycerides (TGL), blood pressure, insulin resistance (by homeostatic model assessment HOMA-index), acanthosis nigricans (AN), uric acid, serum glutamic oxaloacetic transaminase (GOT) and alanine transaminase, and hepatic sonogram." | 3.83 | Models Predictive of Metabolic Syndrome Components in Obese Pediatric Patients. ( Barrera-de Leon, JC; Colunga Rodríguez, C; Hurtado López, EF; López Beltrán, AL; Ortega-Cortes, R; Tlacuilo-Parra, A; Trujillo, X, 2016) |
| "Subject age and measurements of liver enzymes, γ- glutamyl transpeptidase (γGT), uric acid, high-density lipoprotein cholesterol, and insulin resistance were significantly different between the non-NAFLD group and NAFLD group." | 3.83 | Insulin resistance, body composition, and fat distribution in obese children with nonalcoholic fatty liver disease. ( Chang, EJ; Yang, HR, 2016) |
| "Inefficient renal excretion of uric acid is the main pathophysiological mechanism for hyperuricemia in gout patients." | 3.81 | Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients. ( Aniel-Quiroga, MA; Chinchilla, SP; Erauskin, GG; Herrero-Beites, AM; Merriman, T; Perez-Ruiz, F, 2015) |
| "We tested the hypothesis that uric acid levels are higher in subjects with schizophrenia treated with clozapine than in healthy control and they correlate with anthropometric measurements, laboratory tests and results of bioimpedance analysis of body composition." | 3.81 | Uric acid levels in patients with schizophrenia on clozapine monotherapy. ( Kłoszewska, I; Wysokiński, A, 2015) |
| "This study examines the effects of malondialdehyde (MDA) and uric acid on insulin resistance and atherogenicity in subjects with and without mood disorders, the metabolic syndrome (MetS) and tobacco use disorder (TUD)." | 3.81 | Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder. ( Barbosa, DS; Berk, M; Bortolasci, CC; de Castro, MR; de Melo, LG; Dodd, S; Maes, M; Moreira, EG; Vargas Nunes, SO; Vargas, HO, 2015) |
| " Linear regression was used to evaluate associations between uric acid and clinical and laboratory findings associated with metabolic syndrome." | 3.81 | [Metabolic complications of obesity during adolescence, particularly regarding elevated uric acid levels]. ( Almási, A; Barkai, L; Fehér, V; Kiss-Tóth, E; Ságodi, L, 2015) |
| "To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity." | 3.81 | [The role of uric acid in the insulin resistance in children and adolescents with obesity]. ( Almeida, GG; Belo, VA; Cunha, MB; de Miranda, JA; dos Santos, JE; Lanna, CM; Martins, RI; Mourão-Júnior, CA, 2015) |
| " There were positive correlations between NAFLD and insulin resistance index (HOMA-IR), free fatty acids (FFA), tumor necrosis factor-α (TNF-α), omentin-1, visceral fat area, homocysteine (HCY), and serum uric acid (UA)." | 3.81 | Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus. ( Di, F; Gao, L; Jia, G; Li, N; Li, Q; Shao, J; Wang, L; Wang, Q, 2015) |
| " With the reduction of serum potassium quartiles, participants were tended to have higher level of triglycerides and uric acid, lower level of high-density lipoprotein cholesterol (HDL-C), larger waist circumference and more severe insulin resistance." | 3.80 | Serum potassium level is associated with metabolic syndrome: a population-based study. ( Bi, Y; Li, M; Liu, J; Lu, J; Ning, G; Su, T; Sun, K; Xu, B; Xu, M, 2014) |
| " The changes of BMI-SDS in the time period of 1-year were related to baseline fasting insulin resistance index HOMA, blood pressure, waist circumference, waist-to-height ratio, lipids, uric acid, and HbA1c." | 3.80 | Components of the metabolic syndrome are negative predictors of weight loss in obese children with lifestyle intervention. ( Knop, C; Reinehr, T; Uysal, Y; Wolters, B, 2014) |
| " We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxidant, affects the following: 1) systemic (plasma and saliva) nonenzymatic antioxidant capacity (NEAC); 2) markers of systemic (urinary 8-iso-prostaglandin-F2α) and muscle (carbonylated protein content) oxidative stress; and 3) whole-body insulin sensitivity (percentage increase in glucose uptake during a hyperinsulinemic-euglycemic clamp procedure)." | 3.80 | Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. ( Colic Baric, I; Fabbrini, E; Hazen, SL; Klein, S; Serafini, M, 2014) |
| " Despite evidence of uric acid-induced endothelial dysfunction, a relationship with insulin resistance has not been clearly established." | 3.80 | Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. ( Choi, YJ; Hien, TT; Kang, DH; Kang, KW; Kim, KC; Lee, BH; Lee, J; Lee, KY; Lee, MY; Lee, SM; Yoon, Y, 2014) |
| " Systolic blood pressure, fasted plasma parameters, insulin sensitivity, plasma norepinephrine (NE), uric acid, and angiotensin II (Ang II) were determined following 9 weeks of treatment." | 3.80 | Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension. ( MacLeod, KM; McNeill, JH; Tran, LT, 2014) |
| "Increased serum uric acid levels and vascular atherosclerosis are very common in diabetes." | 3.80 | Serum uric acid is associated with arterial stiffness in men with newly diagnosed type 2 diabetes mellitus. ( Sun, H; Xiang, G; Xiang, L; Zhang, J, 2014) |
| "To investigate the relationship among serum uric acid levels and metabolic syndrome." | 3.80 | Serum uric acid levels and metabolic syndrome. ( Ciarla, S; Ferri, C; Giorgini, P; Necozione, S; Properzi, G; Striuli, R; Struglia, M, 2014) |
| "This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension." | 3.80 | Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension. ( Chen, B; Deng, W; Zhang, J; Zhang, Y, 2014) |
| " Fructose administration resulted in significant increase in body weight, elevations of blood glucose, serum insulin, cholesterol, triglycerides, advanced glycation end products (AGEs), uric acid levels, insulin resistance index and blood pressure compared to control rats." | 3.80 | Ursodeoxycholic acid ameliorates fructose-induced metabolic syndrome in rats. ( Elshazly, SM; Mahmoud, AA, 2014) |
| "Parameters were correlated with homeostasis model assessment for insulin resistance, fasting insulin, blood pressure, transaminases, lipids and uric acid, applying adjusted regression models, with age group, pubertal stage and gender as covariates." | 3.79 | Body mass index, waist circumference, and waist-to-height ratio as predictors of cardiometabolic risk in childhood obesity depending on pubertal development. ( Blüher, S; Holl, RW; Kiess, W; L'Allemand-Jander, D; Molz, E; Otto, KP; Sergeyev, E; Tuschy, S; Wiegand, S, 2013) |
| "High uric acid (UA) levels and metabolic syndrome (MS) are risk factors for atherosclerotic diseases." | 3.79 | Relationship between uric acid and arterial stiffness in the elderly with metabolic syndrome components. ( Sun, N; Tian, JL; Wang, H; Zhang, Y, 2013) |
| " In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose." | 3.79 | A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress. ( Hong, E; Moreno, JA, 2013) |
| " The higher CRP group was discriminated by the above variables in addition to lower VO(2max), serum metabolic syndrome components (triglycerides, glucose, and HDL cholesterol), higher insulin, homeostasis assessment of insulin resistance, uric acid, gamma-GT, and homocysteine." | 3.79 | Pathological and behavioral risk factors for higher serum C-reactive protein concentrations in free-living adults--a Brazilian community-based study. ( Burini, RC; de Oliveira, EP; Manda, RM; Michelin, E; Moreto, F; Teixeira, O; Torezan, GA, 2013) |
| "Experimental and observational studies suggest a role for uric acid in non-alcoholic fatty liver disease (NAFLD)." | 3.79 | Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. ( Chonchol, M; Jalal, DI; Johnson, RJ; McFann, K; Sirota, JC; Targher, G, 2013) |
| " Serum glucose, lipids, uric acid, insulin and vaspin were measured at the 2nd and 3rd trimester of pregnancy and postpartum." | 3.79 | Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum. ( Anastasilakis, AD; Dagklis, T; Gavana, E; Gerou, S; Giannoulis, C; Gkiomisi, A; Kourtis, A; Makedou, KG; Polyzos, SA; Rousso, D, 2013) |
| " Blood pressure, lipids, glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR) and uric acid levels were compared across BMI groups." | 3.79 | Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk. ( Brines, J; de Onis, M; Martínez-Costa, C; Montal, A; Nguefack-Tsague, G; Núñez, F, 2013) |
| " Since low urine pH is the main risk factor for uric acid urolithiasis (UAU), UAU may be regarded as a renal manifestation of the MS." | 3.78 | Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. ( Schubert, G; Strohmaier, WL; Wrobel, BM, 2012) |
| " Our aims were to determine the relationship between uric acid and insulin resistance and to define the optimal uric acid cutoff to identify insulin resistance in women." | 3.78 | Optimal uric acid threshold to identify insulin resistance in healthy women. ( Balbín, E; Carbajal, HA; Dulbecco, CA; Espeche, WG; March, CE; Marillet, AG; Salazar, MR, 2012) |
| "The objective of this study was to explore the relationships between circulating uric acid and lipid levels and components of the metabolic syndrome (MetS) in Arab dyslipidemic patients, a group already at high coronary artery disease risk." | 3.78 | Determinants of blood uric acid levels in a dyslipidemic Arab population. ( Akanji, AO; Al-Meshaweh, AF; Asem, M; Jafar, Y, 2012) |
| "In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats." | 3.78 | Melatonin improves metabolic syndrome induced by high fructose intake in rats. ( Kitagawa, A; Ohashi, K; Ohta, Y, 2012) |
| " The study measured the serum high sensitivity C-reactive protein (CRP) as an inflammatory marker, serum insulin as a marker of insulin resistance and serum high-molecular-weight adiponectin (HMW-adipo), in addition to the serum levels of liver enzymes and uric acid." | 3.78 | Predictive ability of serum high-molecular-weight adiponectin in combination with serum insulin and serum C-reactive protein for the presence of metabolic syndrome. ( Hasegawa, M; Kawada, T, 2012) |
| " At the end of the feeding schedule, Dia group had insulin resistance along with increased blood glucose, triglyceride, uric acid and nitric oxide (NO) levels." | 3.78 | Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. ( Bagul, PK; Banerjee, SK; Bastia, T; Chakravarty, S; Madhusudana, K; Matapally, S; Middela, H; Padiya, R; Reddy, BR, 2012) |
| " Elevated serum uric acid levels, hypoadiponectinemia and arterial stiffness are strongly associated with cardiovascular diseases." | 3.78 | Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women. ( Ahn, CW; Cha, BS; Kang, S; Kim, KR; Lee, HC; Park, JS, 2012) |
| "Uric acid, the levels of which have been shown to increase after menopause, has been associated with metabolic syndrome." | 3.77 | Relationship between uric acid and metabolic syndrome according to menopausal status. ( Ahn, KH; Cho, GJ; Hur, JY; Kim, SH; Kim, T; Kim, YT; Lee, HJ; Park, HT; Shin, JH; Yi, KW, 2011) |
| " Blood pressure and uric acid was most strongly correlated with body weight and height (heavier and taller boys)." | 3.77 | Differential relationships between anthropometry measures and cardiovascular risk factors in boys and girls. ( Beilin, LJ; de Klerk, N; Hands, B; Huang, RC; Landau, LI; Mori, TA; Newnham, JP; Oddy, WH; Stanley, FJ, 2011) |
| " MRFs (serum lipid profile, insulin resistance indexes, blood pressure) in addition to uric acid, homocysteine, leptin, and inflammatory markers were measured." | 3.77 | Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. ( Alonso-Iglesias, E; Codoñer-Franch, P; Megías-Vericat, J; Murria-Estal, R; Tavárez-Alonso, S; Tortajada-Girbés, M, 2011) |
| " A clinical study on 467 patients with nephrolithiasis at our institution revealed that clustering of MetS traits increased the risk of uric acid stone formation by decreasing urinary pH." | 3.77 | [Metabolic syndrome and nephrolithiasis]. ( Hara, I; Iba, A; Kohjimoto, Y; Sasaki, Y, 2011) |
| "In both men and women, we observed positive linearity between GGT quartiles and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, high-sensitive C-reactive protein (hsCRP) and homeostatic model assessment of insulin resistance (HOMA-IR) score (P for trends < 0·001)." | 3.77 | Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals. ( Bae, SJ; Jung, CH; Kim, HK; Kim, MS; Koh, EH; Lee, WJ; Park, JY; Yu, JH, 2011) |
| "This study aimed to evaluate the association of serum inflammatory markers (C-reactive protein (CRP) and uric acid (UA)), magnesium and other CVD risk factors with insulin resistance (IR) among Chinese postmenopausal women with prediabetes." | 3.77 | The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes. ( Ho, SC; Liu, ZM, 2011) |
| " It specifically addressed the hypotheses that renal dysfunction in these patients may associate with the presence of insulin resistance, dyslipidaemia, uric acid levels and/or current levels of systemic inflammation." | 3.76 | Cardiovascular risk factors and not disease activity, severity or therapy associate with renal dysfunction in patients with rheumatoid arthritis. ( Antonopoulos, I; Daoussis, D; Douglas, KM; John, H; Kitas, GD; Nightingale, P; Panoulas, VF; Toms, TE; Wong, P, 2010) |
| "Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance." | 3.76 | Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. ( Lee, HR; Lee, JH; Lee, YJ; Shim, JY; Shin, YH, 2010) |
| " Multivariate logistic regression analysis showed that the OR of having hyperuricemia at the 6-year followup was significantly associated with the Arg64 allele, after adjusting for age, weight gain, baseline levels of triglycerides, serum uric acid, and insulin resistance (OR 3." | 3.76 | Trp64Arg polymorphism of the ADRB3 gene predicts hyperuricemia risk in a population from southern Spain. ( de la Cruz Almaraz, M; García-Fuentes, E; Gómez-Zumaquero, JM; Martín-Núñez, GM; Morcillo, S; Rojo-Martínez, G; Ruiz de Adana, M; Soriguer, F, 2010) |
| " Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased." | 3.76 | Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010) |
| "Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established." | 3.76 | Clinical value of serum uric Acid in patients with suspected coronary artery disease. ( Kim, EJ; Kim, JW; Kim, SH; Lim, HE; Park, CG; Rha, SW; Seo, HS, 2010) |
| " In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis." | 3.76 | Relationship between insulin resistance and inflamation markers in hemodialysis patients. ( Binici, DN; Borazan, A, 2010) |
| "to obtain prevalence of insulin resistance among siblings of subjects with type 2 DM and their metabolic abnormality profiles as measured by their BMI, waist circumference (WC), blood pressure, glucose intolerance, concentration of triglyceride, HDL cholesterol, and uric acid." | 3.76 | Insulin resistance profile among siblings of type 2 diabetes mellitus (preliminary study). ( Gumiwang, I; Oemardi, M; Purnamasari, D; Soegondo, S, 2010) |
| "Uric acid is heritable and associated with hypertension and insulin resistance." | 3.75 | Genome-wide linkage analysis for uric acid in families enriched for hypertension. ( Asmann, Y; Boerwinkle, E; Fridley, BL; Hunt, SC; Mosley, TH; Pankow, JS; Rule, AD; Turner, ST, 2009) |
| " Rosiglitazone was also administered to demonstrate whether improved insulin sensitivity would prevent high-purine diet induced renal injury and gouty-like lesions." | 3.75 | Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions. ( Gu, J; Li, C; Li, Y; Meng, D; Miao, Z; Wang, B; Wang, CY; Wang, J; Wang, L; Xing, X; Yan, S; Yuan, Y; Zhang, S, 2009) |
| " At moderate or high doses, an effect on any one marker may be absent or even the opposite of that observed at very high or excessive doses; examples include fasting plasma triglyceride, insulin sensitivity, and the putative marker uric acid." | 3.75 | Fructose ingestion: dose-dependent responses in health research. ( Livesey, G, 2009) |
| "The aim of this study was to determine urinary excretion of calcium, uric acid and sodium and to evaluate insulin resistance in patients with nephrolithiasis and blood hypertension, isolated and in association, and in healthy controls, in absence of obesity and diabetes." | 3.75 | Patients with nephrolithiasis and blood hypertension have higher calciuria than those with isolated nephrolithiasis or hypertension? ( Casulari, LA; Costa, SS; Reis, MC; Rodrigues, MP; Schleicher, MM, 2009) |
| "The aim of this prospective study was to evaluate results of metformin (MF) therapy during 1 year of uric acid (UA) metabolism and the clinical course of gout with insulin resistance (IR)." | 3.75 | [Effect of metformin on the clinical course of gout and insulin resistance]. ( Aleksandrova, EN; Barskova, VG; Eliseev, MS; Kudaeva, FM; Nasonov, EL; Nasonova, VA; Volkov, AV, 2009) |
| "We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth." | 3.75 | Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women. ( Catov, J; Laughon, SK; Roberts, JM, 2009) |
| "The aim of this study is to investigate the respective associations of alanine aminotransferase (ALT), white blood cell (WBC) count, and uric acid with metabolic syndrome and compare the magnitude in their association with metabolic syndrome, using modified Adult Treatment Panel III (ATP III) and its components." | 3.74 | Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults. ( Kang, YH; Kim, IJ; Kim, YK; Min, HG; Son, SM, 2008) |
| "Perfusion of rat urinary bladder with uric acid (UA) or 1-methyl uric acid (1-MUA) solution was reported to produce features of metabolic syndrome, viz." | 3.74 | Role for the urinary bladder in pathogenesis of metabolic syndrome in Wistar rats. ( Balasubramanian, T, 2008) |
| "This study investigates the impact of uric acid (UA) on the risk factors associated with metabolic syndrome." | 3.74 | Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid. ( Chang, HY; Chiou, WK; Lin, JD; Liu, FH; Weng, HF, 2007) |
| "We investigated the relationship between serum uric acid (SUA) and body fat area, serum lipid level, insulin resistance, and metabolic syndrome in Japanese men." | 3.74 | Relationship between hyperuricemia and body fat distribution. ( Hikita, M; Hosoya, T; Ichida, K; Mori, Y; Ohno, I; Yokose, T, 2007) |
| " Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance." | 3.74 | Thiazide diuretics exacerbate fructose-induced metabolic syndrome. ( Johnson, RJ; Mu, W; Nakagawa, T; Reungjui, S; Roncal, CA; Sirivongs, D; Srinivas, TR, 2007) |
| "Elevated serum uric acid level is associated with obesity, insulin resistance, diabetes, nephropathy, and hypertension." | 3.74 | Genome scan for determinants of serum uric acid variability. ( Abboud, HE; Arar, NH; Bauer, R; Blangero, J; Comuzzie, AG; Lopez-Alvarenga, JC; MacCluer, JW; Nath, SD; Thameem, F; Voruganti, VS, 2007) |
| "We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects." | 3.74 | Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. ( Bonadonna, RC; Bonora, E; Capaldo, B; De Mattia, G; Del Prato, S; Frittitta, L; Frontoni, S; Leonetti, F; Luzi, L; Marchesini, G; Marini, MA; Natali, A; Paolisso, G; Perin, PC; Piatti, PM; Pujia, A; Solini, A; Vettor, R, 2008) |
| "Type 2 diabetes is associated with an increased risk of nephrolithiasis, specifically in the form of uric acid (UA) nephrolithiasis." | 3.74 | Diabetes and nephrolithiasis. ( Daudon, M; Jungers, P, 2007) |
| "To evaluate haemoglobin A1c (HbA1c), fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels in a nationally representative sample of men and women." | 3.74 | Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey. ( Choi, HK; Ford, ES, 2008) |
| "To assess the correlation between serum uric acid and insulin resistance in natural population of Beijing." | 3.74 | [Correlation between serum uric acid and insulin resistance]. ( Li, GW; Liu, J; Liu, S; Qin, LP; Wang, M; Wang, W; Zhao, D; Zhou, GH, 2007) |
| "The purpose of this study was to assess a possible correlation between insulin resistance and uric acid levels in gestational hypertension (GH) and preeclampsia." | 3.73 | Elevated serum uric acid levels in gestational hypertension are correlated with insulin resistance. ( Cohen, O; Homko, CJ; Schiff, E; Sivan, E; Weisz, B, 2005) |
| "The levels of the liporegulatory hormone leptin are increased in obesity, which contributes to the metabolic syndrome; the latter is associated with elevated cardiovascular risk and morbidity." | 3.73 | Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans. ( Chraibi, A; Israili, ZH; Lyoussi, B; Mguil, M; Ragala, MA, 2005) |
| " The present study examined a Korean adult population with respect to the relationships between serum uric acid concentrations and hypertension, insulin resistance, and the risk factors of metabolic syndrome." | 3.73 | Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. ( Kang, JH; Keum, DG; Kim, BJ; Kim, BS; Kim, H; Kim, SW; Lee, MH; Lee, WY; Park, JR; Rhee, EJ; Ryu, SH; Shin, HS; Sung, KC; Yoo, TW, 2005) |
| "This study was performed to test whether plasma homocysteine concentrations are related to insulin resistance in healthy premenopausal women." | 3.73 | Insulin resistance is not related to plasma homocysteine concentration in healthy premenapausal women. ( Bekpinar, S; Orhan, Y; Tanrikulu-Kiliç, F; Unlüçerçi, Y, 2006) |
| " Because insulin resistance, characteristic of the metabolic syndrome and type 2 diabetes, results in lower urine pH through impaired kidney ammoniagenesis and because a low urine pH is the main factor of uric acid (UA) stone formation, it was hypothesized that type 2 diabetes should favor the formation of UA stones." | 3.73 | Type 2 diabetes increases the risk for uric acid stones. ( Conort, P; Daudon, M; Jungers, P; Lacour, B; Traxer, O, 2006) |
| "To study the islet beta-cell function in patients with simple hyperuricemia (HUA) and to explore the relationship between the level of serum uric acid and insulin resistance." | 3.73 | [An analysis of islet beta-cell function in hyperuricemia]. ( Jia, SD; Li, J; Wang, YG, 2006) |
| "0001) differences, and correlated significantly in a beneficial manner to measures of obesity (body mass index, waist circumference, and abdominal height), mean arterial blood pressure, lipoprotein variables (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), measures of glucose homeostasis (insulin, glucose, homeostasis model assessment of insulin resistance [HOMA-IR]), and uric acid, after adjusting for age, race, sex, and cigarette smoking." | 3.73 | Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. ( Berenson, GS; Chen, W; Patel, DA; Srinivasan, SR; Xu, JH, 2006) |
| " The degree of obesity did not relate to insulin resistance but was independently correlated with inflammatory proteins, uric acid, and systolic BP, variables that were often abnormal in this population." | 3.72 | Prevalence and concomitants of glucose intolerance in European obese children and adolescents. ( Gilardini, L; Guzzaloni, G; Invitti, C; Morabito, F; Viberti, G, 2003) |
| "Anthropometric parameters, blood lipid spectrum, levels of glucose, uric acid (UA), immunoreactive insulin, HOMA index were studied in 55 male patients with gout (mean age 50." | 3.72 | [Insulin resistance syndrome in patients with gout and its influence on formation of clinical characteristics of the disease]. ( Barskova, VG; Eliseev, MS; Iakunina, IA; Il'inykh, EV; Nasonov, EL; Zilov, AV, 2004) |
| "Blood levels of uric acid, cholesterol, triglycerides (TG), high and low density lipoproteins were examined and glucose tolerance test was made in 108 adolescents with arterial hypertension (AH) and different physical constitution (normal, with overweight and obese)." | 3.72 | [Arterial hypertension in adolescents with different physical constitution including those with signs of metabolic syndrome]. ( Kazakova, LM; Rovda, EIu; Rovda, IuI; Rovda, TS, 2004) |
| " The present study investigated relationships between serum adiponectin levels and body mass index (BMI), blood pressure, insulin resistance index, lipid profile, uric acid and high-sensitivity C-reactive protein levels in a large number of Japanese subjects not taking any medication for metabolic disease and without severe illness (705 men and 262 women; age 30-65 years; BMI 22." | 3.71 | Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. ( Hirose, H; Ishii, T; Matsubara, K; Nishikai, K; Okazaki, Y; Saito, I; Saruta, T; Taniyama, M; Tomita, M; Yamamoto, Y, 2002) |
| "Body weight and BP decreased significantly in the diet group but not in the troglitazone group at the end of the intervention periods." | 3.71 | Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. ( Kamide, K; Kawano, Y; Minami, J; Tsunoda, S, 2002) |
| " Except for them, the gamma-GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index." | 3.71 | Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (gamma-GTP) activity in non-drinkers. ( Hirose, H; Moriya, S; Saito, I; Yokoyama, H, 2002) |
| "To assess the impacts of insulin resistance and renal function on plasma total homocysteine (tHcy) levels in patients with type 2 diabetes with a wide range of nephropathy." | 3.71 | Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes. ( Emoto, M; Inaba, M; Ishimura, E; Kanda, H; Kawagishi, T; Komatsu, M; Mori, K; Nishizawa, Y; Okuno, Y; Shoji, T; Tahara, H, 2001) |
| "Stratified analyses revealed that (1) serum uric acid levels were positively associated with hyperinsulinemia and HOMA-insulin resistance in both men and women after adjusting for hypertriglyceridemia, hypertension, obesity, and plasma glucose levels; and (2) serum uric acid levels were more strongly associated with hyperinsulinemia and plasma glucose levels in women than in men." | 3.71 | Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. ( Chou, P; Lin, HY; Lin, KC; Tsai, ST, 2001) |
| " Mean values of alanine transaminase, gammaglutamyltranspeptidase, triglycerides, uric acid, fasting and log insulin, transferrin percent saturation and ferritin were significantly higher in the patients, while transferrin and quantitative insulin sensitivity check index, a quantitative insulin sensitivity index, were lower." | 3.71 | Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study. ( Bagni, A; Bertolotti, M; Borsatti, A; Carulli, N; Ganazzi, D; Leonardi, F; Lonardo, A; Loria, P; Neri, P; Pulvirenti, M; Verrone, AM, 2002) |
| "Patients with LBS demonstrated similar metabolic features in terms of insulin sensitivity and hyperleptinemia as patients with "simple" truncal obesity." | 3.71 | Insulin resistance, hyperleptinemia, and obstructive sleep apnea in Launois-Bensaude syndrome. ( Ficker, JH; Fuchs, FS; Hahn, EG; Harsch, IA; Konturek, PC; Lohmann, T; Schahin, SP, 2002) |
| "To determine whether fasting serum uric acid is associated with the insulin sensitivity index or with other anthropometric, metabolic or environmental features of the insulin resistance syndrome in a population-based sample of young healthy Caucasians." | 3.70 | Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-based sample of 380 young healthy Caucasians. ( Borch-Johnsen, K; Clausen, JO; Ibsen, H; Pedersen, O, 1998) |
| " The high prevalence and severity of metabolic disturbances associated with the insulin resistance syndrome (hyperglycaemia, hyperinsulinaemia, decreased HDL cholesterol, hypertriglyceridaemia, elevated fibrinogen levels and hyperuricaemia) before gastroplasty were significantly decreased after weight loss." | 3.70 | Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity. ( Desaive, C; Dewe, W; Gielen, JE; Lefebvre, PJ; Luyckx, FH; Scheen, AJ, 1998) |
| " We measured insulin sensitivity using the hyperinsulinaemic euglycaemic clamp (50 mU kg-1 h-1), blood pressure, waist-to-hip ratio, fasting insulin levels, serum lipids and uric acid levels." | 3.70 | Salt sensitivity correlates positively with insulin sensitivity in healthy volunteers. ( Bakker, SJ; Donker, AJ; Gans, RO; ter Maaten, JC; Voordouw, JJ, 1999) |
| "family history of T2DM on the maternal side increased both systolic blood pressure and serum uric acid level in probands, without modification in their insulin sensitivity." | 3.70 | Maternal effect of Type 2 diabetes mellitus on insulin sensitivity and metabolic profile in healthy young Mexicans. ( González-Ortiz, M; Martínez-Abundis, E, 1999) |
| "Significantly higher values were found in the preeclampsia than in the control group for fasting insulin, fasting glucose, fasting insulin resistance index (FIRI, fasting glucose x fasting insulin/25), serum triglycerides, uric acid and blood pressure." | 3.70 | Is carbohydrate metabolism altered among women who have undergone a preeclamptic pregnancy? ( Carlström, K; Erikssen, C; Nisell, H; Persson, B, 1999) |
| "Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease." | 3.69 | Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. ( Landsberg, L; Lee, J; Sparrow, D; Vokonas, PS; Weiss, ST, 1995) |
| "Serum concentrations of insulin, uric acid, total and lipoprotein cholesterol, triglyceride, and apolipoproteins A-I and B were measured in 31 women with pregnancy-induced hypertension (eight with proteinuria) and in 21 healthy, pregnant, weight-matched controls at 30-39 weeks' gestation." | 3.69 | Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women. ( Kaaja, R; Tikkanen, MJ; Viinikka, L; Ylikorkala, O, 1995) |
| "To examine the relationships of serum uric acid concentration with several risk factors of cardiovascular diseases (CVD)." | 3.69 | Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study. ( Bonora, E; Branzi, P; Cacciatori, V; Muggeo, M; Saggiani, F; Santi, L; Targher, G; Tosi, F; Travia, D; Zenere, MB; Zenti, MG, 1996) |
| "In order to study the relationships between obesity, serum uric acid, insulin secretion and insulin resistance in female subjects, we evaluated serum C-peptide and glucose-induced insulin utilization (euglycemic hyperinsulinemic clamp) in 16 obese (8 nonhyperuricemic and 8 hyperuricemic) and 10 nonobese control subjects." | 3.69 | Serum uric acid, insulin secretion and resistance in nonhyperuricemic and hyperuricemic obese female subjects. ( Bonaventura, V; Greco, D; Scarpitta, AM; Sinagra, D, 1996) |
| "Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance." | 3.69 | Normal serum uric acid concentrations in women with polycystic ovary syndrome. ( Anttila, L; Irjala, K; Penttilä, T; Rouru, J, 1996) |
| " Body mass index (BMI), waist/hip ratio (WHR), blood pressure (BP); oral glucose tolerance test (OGTT) with measurement of serum glucose, insulin and C-peptide every 30 min for 2 h, fasting serum cholesterol, triglycerides and uric acid, areas under curve (AUC) of glucose and insulin, insulin/glucose ratio and insulin sensitivity index were calculated." | 3.69 | Hyperinsulinemia in patients with coronary heart disease in absence of overt risk factors. ( Almazán, A; Ariza, CR; Frati, AC; Gómez, G, 1997) |
| "There is an inverse relationship between serum uric acid concentrations and measures of functional capacity in patients with cardiac failure." | 3.69 | Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure. ( Anker, S; Chua, TP; Coats, AJ; Godsland, IF; Leyva, F; Stevenson, JC; Swan, JW; Wingrove, CS, 1997) |
| "The aim of the present study was to evaluate the relationship of C-peptide and the C-peptide/bloodsugar ratio with clinical/biochemical variables presenting a well-known association with insulin resistance in NIDDM patients in acceptable control, obtained without the use of exogenous insulin." | 3.69 | Relationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients. ( Acosta, D; Astorga, R; García de Pesquera, F; Losada, F; Morales, F; Pumar, A; Relimpio, F, 1997) |
| "Magnitude of insulin resistance and serum uric acid concentration were significantly related (r = ." | 3.68 | Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. ( Chen, YD; Facchini, F; Hollenbeck, CB; Reaven, GM, 1991) |
| " However, other cardiometabolic markers were not improved by magnesium supplementation at the above dosage and duration." | 3.11 | Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial. ( Amini, M; Aminorroaya, A; Feizi, A; Salehidoost, R; Taghipour Boroujeni, G, 2022) |
| "Hyperuricemia is a metabolic disease caused by purine nucleotide metabolism disorder." | 3.01 | Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond. ( Cheng, J; Koyama, H; Yamamoto, T; Yu, W, 2023) |
| "In summary, we propose that Alzheimer's disease may be the consequence of a maladaptation to an evolutionary-based survival pathway and what had served to enhance survival acutely becomes injurious when engaged for extensive periods." | 3.01 | Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? ( Bredesen, D; Burtis, S; Fini, M; Johnson, RJ; Lanaspa, MA; Nagel, M; Perlmutter, D; Sánchez-Lozada, LG; Tolan, DR, 2023) |
| "Insulin sensitivity was assessed by hyperinsulinaemic-euglycaemic clamps and cardiovascular variables were measured." | 2.84 | Comparison of the effects of diets high in animal or plant protein on metabolic and cardiovascular markers in type 2 diabetes: A randomized clinical trial. ( Hornemann, S; Markova, M; Pfeiffer, AFH; Pivovarova, O; Rohn, S; Rudovich, N; Schneeweiss, R; Sucher, S; Thomann, R, 2017) |
| " We suggest that these adverse effects are at least in part the result of suppressed activity of sirtuins, particularly Sirtuin1." | 2.82 | Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis. ( Garcia-Arroyo, FE; Johnson, RJ; Lanaspa, MA; Nakagawa, T; Rodriguez-Iturbe, B; Sánchez-Lozada, LG, 2022) |
| "Insulin resistance was calculated using homeostasis assessment model (HOMA-IR)." | 2.76 | Insulin resistance in non-obese women with polycystic ovary syndrome: relation to byproducts of oxidative stress. ( Bjekic-Macut, J; Bozic, I; Damjanovic, S; Djukic, T; Lissounov, A; Macut, D; Matic, M; Petakov, M; Pljesa-Ercegovac, M; Savic-Radojevic, A; Simic, T; Suvakov, S, 2011) |
| "Insulin resistance was conventionally defined as the upper quartile of the HOMA-IR values." | 2.76 | Clinical and biochemical indicators of homeostasis model assessment-estimated insulin resistance in postmenopausal women. ( Hsiao, LC; Hwu, CM; Lin, KH; Liou, TL, 2011) |
| "Recently, nephrolithiasis has been reported to be involved with renal manifestation of metabolic syndrome." | 2.73 | Relationship between insulin resistance and low urinary pH in patients with gout, and effects of PPARalpha agonists on urine pH. ( Inokuchi, T; Ka, T; Kobayashi, T; Moriwaki, Y; Takahashi, S; Tsutsumi, Z; Yamamoto, T, 2007) |
| "Insulin resistance was calculated with the homeostasis model assessment." | 2.73 | Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance. ( Almaraz, MC; Cardona, F; Cardona, I; Collantes, E; Garrido-Sánchez, L; Rojo-Martínez, G; Soriguer, F; Tinahones, FJ; Vázquez-Mellado, J, 2008) |
| "The uric acid concentration was significantly higher in postmenopausal versus premenopausal women." | 2.69 | The effect of menopause on serum uric acid levels in non-obese healthy women. ( Stevenson, JC; Walton, C; Wingrove, CS, 1998) |
| "In conclusion, 24-hr sleep deprivation decreased the insulin sensitivity in healthy subjects without changes in cortisol levels." | 2.69 | Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects. ( Balcázar-Muñoz, BR; González-Ortiz, M; Martínez-Abundis, E; Pascoe-González, S, 2000) |
| "In contrast, hyperinsulinemia caused a significant decrease in the urinary excretion of uric acid (2." | 2.68 | Effect of insulin on renal sodium and uric acid handling in essential hypertension. ( Bianchi, S; Bigazzi, R; Ciociaro, D; Ferrannini, E; Frascerra, S; Galvan, AQ; Muscelli, E; Natali, A; Sironi, AM, 1996) |
| "Obesity was prevalent in both groups." | 2.67 | [Forestier disease and metabolism disorders. A prospective controlled study of 25 cases]. ( Gerster, JC; Troillet, N, 1993) |
| "Hyperuricemia has been linked to metabolic syndrome, cardiovascular disease, and chronic kidney disease." | 2.55 | Effects of Sodium Glucose Cotransporter-2 Inhibitors on Serum Uric Acid in Type 2 Diabetes Mellitus. ( Ahmadieh, H; Azar, S, 2017) |
| "Nonalcoholic fatty liver disease (NAFLD) is a major, worldwide public health problem." | 2.53 | Serum uric acid: a new therapeutic target for nonalcoholic fatty liver disease. ( Braddock, M; Liu, WY; Lu, QD; Shi, KQ; Song, D; Sun, DQ; Wu, SJ; Zheng, MH; Zhu, GQ, 2016) |
| "Hypocitraturia and hypercalciuria are risk factors for calcium stone disease." | 2.47 | Diet-induced metabolic acidosis. ( Adeva, MM; Souto, G, 2011) |
| "Hyperuricemia is a prevalent finding in patients presenting metabolic syndrome, although its clinical meaning is still controversial and often underestimated." | 2.46 | Uric acid as a factor in the metabolic syndrome. ( Batista, MC; Borges, RL; Ribeiro, AB; Zanella, MT, 2010) |
| "Uric acid is a major product of purine metabolism in humans." | 2.46 | Uric acid and the development of hypertension. ( Hwu, CM; Lin, KH, 2010) |
| "Uric acid may increase as a result of pathophysiological processes such as impaired renal sodium handling but may also contribute to renal and vascular damage, particularly endothelial dysfunction." | 2.43 | Uric acid and hypertension. ( Schachter, M, 2005) |
| "Gout is the most common inflammatory arthritis in men, affecting approximately 1-2% of adult men in Western countries." | 2.43 | Recent developments in diet and gout. ( Kavanaugh, A; Lee, SJ; Terkeltaub, RA, 2006) |
| "In contrary, the so-called type 2 diabetes is a multifactorial, often hyperinsulinaemic condition of insulin resistance and it occurs mainly in the adults." | 2.40 | [From type 2 diabetes to metabolic X syndrome]. ( Pogátsa, G, 1999) |
| "Insulin resistance/hyperinsulinemia, in turn, is associated with a series of hypertensiogenic and atherogenic side effects, aggravating the individual components of the metabolic syndrome." | 2.39 | [The metabolic syndrome. Pathophysiologic causes, diagnosis, therapy]. ( Rett, K; Standl, E; Wicklmayr, M, 1994) |
| "One hundred sixty NIDDM patients who had undergone the clamp study were stratified into 5 groups according to the serum uric acid level." | 2.39 | [Hyperuricemia and insulin resistance]. ( Iwatani, M; Katsumori, K; Saeki, A; Wasada, T, 1996) |
| "Both hyperprolactinemia and early-onset androgenic alopecia are associated with increased cardiometabolic risk." | 1.91 | Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia. ( Basiak, M; Krysiak, R; Okopień, B; Szkróbka, W, 2023) |
| "In total, 673 patients with type 2 diabetes met the inclusion criteria." | 1.91 | The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease. ( Li, HF; Li, Y; Miao, X, 2023) |
| "First-degree relatives (FDR) of type 2 diabetes mellitus have increased risk of developing insulin resistance-related disorders including hyperuricemia." | 1.91 | The role of high fat diet on serum uric acid level among healthy male first degree relatives of type 2 diabetes mellitus. ( Muhadi, M; Purnamasari, D; Tahapary, DL; Tarigan, TJE; Tricaesario, C; Umpuan, ARM; Wisnu, W, 2023) |
| "Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males." | 1.72 | Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults. ( Bao, Q; Cai, S; Cheng, B; Li, M; Ma, S; Su, Y; Sun, J; Sun, M; Wang, S; Zhang, A; Zhang, Y; Zhu, P, 2022) |
| "Insulin sensitivity was assessed using Homeostatic Model Assessment of Insulin Resistance and the Matsuda Insulin Sensitivity Index." | 1.72 | Ethnic and sex differences in hepatic lipid content and related cardiometabolic parameters in lean individuals. ( Dufour, S; Li, F; Petersen, KF; Rothman, DL; Shulman, GI, 2022) |
| "Low-grade inflammation has been postulated to have a key role in the pathogenesis of MetS and has been linked to insulin resistance (IR)." | 1.72 | Association Between Low-Grade Inflammation and Hyperuricemia in Adults With Metabolic Syndrome in Yucatán, México. ( Avila-Nava, A; Banik, SD; Chim Aké, R; Gutiérrez Solis, AL; Lugo, R, 2022) |
| "Phthalimide derivatives have been extensively researched with various biological actions." | 1.72 | Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance. ( da Rocha, IG; da Silva Júnior, JG; da Silva Neto, JC; de Araújo, HDA; de Menezes Lima, VL; de Oliveira Assis, SP; Oliveira, RN, 2022) |
| " In conclusion, long-term intake of fructose and prednisolone by male rats are more detrimental to glucose and lipid homeostasis than if ingested separately and the benefits of treatment interruption are broader than fish oil treatment." | 1.62 | Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. ( Brunetta, HS; Chagas, TR; da Silva, JS; Nunes, EA; Rafacho, A; Santos, CD; Zoccal, DB, 2021) |
| "In the reverse direction analysis, genetic predisposition to both urate and gout were not associated with T2D or any of 4 glycemic traits being investigated." | 1.62 | Genetic Predisposition to Type 2 Diabetes and Insulin Levels Is Positively Associated With Serum Urate Levels. ( Fan, J; Li, Y; Sun, L; Tse, LA; Yang, J; Zhu, J, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with few therapeutic options available currently." | 1.62 | Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota. ( Chen, L; Han, R; Hong, Y; Li, B; Li, H; Ma, J; Qiu, H; Sheng, L; Wu, G; Zheng, N; Zhong, J, 2021) |
| "Hyperuricemia is closely associated with insulin resistance syndrome (and its many cardiometabolic sequelae); however, whether they are causally related has long been debated." | 1.62 | Assessing the Causal Relationships Between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization. ( Choi, HK; Leong, A; McCormick, N; Merriman, TR; Mount, DB; O'Connor, MJ; Yokose, C, 2021) |
| "Allopurinol treatment significantly reduced MAGE (4." | 1.56 | Blood glucose fluctuations detected by continuous glucose monitoring system in gout patients with normal glucose tolerance and the effect of urate-lowering therapy. ( Chen, Y; Dong, B; Lv, W; Mu, Z; Wang, F; Wang, J; Wang, W; Wang, Y; Wang, Z; Zhao, Y, 2020) |
| "Insulin resistance was assessed by the homeostatic model assessment (HOMA) index." | 1.56 | Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance. ( Andreozzi, F; Armentaro, G; Cassano, V; Crescibene, D; Hribal, ML; Magurno, M; Maio, R; Miceli, S; Pelaia, C; Perticone, F; Perticone, M; Sciacqua, A; Sesti, G; Toscani, A, 2020) |
| "l-Carnitine is an antioxidant, affecting mitochondria and cellular energetics; however, little is known about its effects in hyperuricemic states." | 1.51 | Possible role of l-carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic-Fructose-supplemented rats. ( Ahmed, MA; El-Kafoury, BMA; ElKady, AH; Hammouda, GA; Lasheen, NN, 2019) |
| " Multiple regression analyses resulted in a significant positive association with lumbar spine BMD across SUA quintiles in a dose-response manner after adjusting for various confounding factors (p = 0." | 1.51 | Higher serum uric acid is associated with higher lumbar spine bone mineral density in male health-screening examinees: a cross-sectional study. ( Ahn, JK; Hwang, J; Hwang, JH; Ryu, S, 2019) |
| "Patients with UA nephrolithiasis have normal acid-base parameters assessed according to conventional clinical tests." | 1.48 | Uric Acid Renal Lithiasis: New Concepts. ( Pazos Pérez, F, 2018) |
| "Although MS and NAFLD were more prevalent in adolescents, young children also demonstrated MS and NAFLD as obesity-related complications." | 1.48 | Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity. ( Cho, J; Kim, JY; Yang, HR, 2018) |
| "Hepatic insulin resistance was estimated by the liver IR index." | 1.48 | Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals. ( Andreozzi, F; Fiorentino, TV; Hribal, ML; Pedace, E; Perticone, F; Sciacqua, A; Sesti, F; Sesti, G; Succurro, E, 2018) |
| "As uric acid levels increase there is a relevant clustering of metabolic risk factors, whereas elevated blood pressure is the risk factor less frequently present." | 1.48 | Uric acid is linked to cardiometabolic risk factors in overweight and obese youths. ( Alvarez-Pitti, J; Borghi, C; Lurbe, E; Redon, J; Redon, P; Torro, MI, 2018) |
| "Insulin resistance is characterized by the failure of target cells to respond to normal levels of circulating insulin, and this condition is related to cardiovascular disease." | 1.46 | Insulin resistance and associated factors: a cross-sectional study of bank employees. ( Bissoli, NS; Cattafesta, M; Molina, MDCB; Salaroli, LB; Zandonade, E, 2017) |
| "Obese children with NAFLD were studied (n=271)." | 1.46 | Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. ( Alisi, A; Byrne, CD; Crudele, A; De Vito, R; Mosca, A; Nobili, V; Scorletti, E; Villani, A, 2017) |
| "The development of insulin resistance is closely related with the increased levels of TC, TG, BMI, WHR, and BUA." | 1.43 | [Association of Insulin Resistance and β Cell Function with Lipid Metabolism in Middle-aged and Elderly Hui and Han Populations]. ( Cheng, YX; Fan, YJ; Hu, XQ; Huang, Q; Jiang, M; Li, SY; Liu, L; Liu, XY; Ma, R; Ma, YY; Wang, PP; Wang, ZZ; Yao, TY; Yu, JJ; Zhang, JL, 2016) |
| "The prevalence rates of NAFLD were 71." | 1.43 | Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults. ( Chen, N; He, CM; Li, X; Li, Z; Liu, CQ; Liu, S; Liu, Y; Shi, X; Wang, D; Yan, B; Yang, S; Zeng, X, 2016) |
| "Children with histologically proven NAFLD, and obese and lean controls received oral fructose (1 g kg(-1) ideal body weight)." | 1.42 | Oral fructose absorption in obese children with non-alcoholic fatty liver disease. ( Johnson, RJ; Le, MT; Love-Osborne, K; Pan, Z; Rivard, C; Robbins, K; Sokol, RJ; Sullivan, JS; Sundaram, SS, 2015) |
| "Whether nonalcoholic fatty liver disease (NAFLD) is related to vitamin D and bone health in obese children is unknown." | 1.42 | Vitamin D Status and Bone Mineral Density in Obese Children with Nonalcoholic Fatty Liver Disease. ( Chang, EJ; Yang, HR; Yi, DY, 2015) |
| "Insulin resistance is associated with inadequate body composition, in biochemical levels and lifestyle, being the factors associated different in each phase of adolescence." | 1.40 | [Insulin resistance and components of metabolic syndrome, analysis by gender and stage of adolescence]. ( Faria, ER; Faria, FR; Franceschini, Sdo C; Novaes, JF; Peluzio, Mdo C; Priore, SE; Ribeiro, AQ; Ribeiro, SM; Sant Ana, LF, 2014) |
| "Hyperuricemia has been shown to be a strong correlate of hypertension in children." | 1.39 | Serum uric acid and blood pressure in children at cardiovascular risk. ( Antolini, L; Brambilla, P; Galbiati, S; Genovesi, S; Giussani, M; Mastriani, S; Pontremoli, R; Stella, A; Valsecchi, MG; Viazzi, F, 2013) |
| "By analysing factors associated with diabetic nephropathy rather than microvascular disease in general, this study provides evidence that night-time diastolic BP and a relative increase in platelet count are associated with incipient diabetic nephropathy." | 1.38 | Factors associated with diabetic nephropathy in subjects with proliferative retinopathy. ( Buhagiar, G; Calleja, N; Fava, S; Magri, CJ; Vassallo, J, 2012) |
| "Hyperuricemia is common in those subjects and might be considered a potential clinical parameter in the definition of MetS." | 1.38 | Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel. ( Cohen, E; Fraser, A; Garty, M; Goldberg, E; Krause, I, 2012) |
| "Insulin sensitivity was estimated using the homeostatic model assessment index (HOMA-B) for beta cell function and HOMA-IR for peripheral tissue IR." | 1.38 | Insulin resistance and metabolic syndrome in primary gout: relation to punched-out erosions. ( El-Fishawy, HS; Gheita, TA; Hussein, H; Nasrallah, MM, 2012) |
| "A total of 102 type 2 diabetes mellitus patients were divided into 2 groups: DR group (age, 60 +/- 6 years [mean +/- SD]; n = 31) and no diabetic retinopathy (NDR) group (59 +/- 5 years, n = 71)." | 1.36 | Diabetic retinopathy is associated with visceral fat accumulation in Japanese type 2 diabetes mellitus patients. ( Anan, F; Eshima, N; Eto, T; Ito, Y; Masaki, T; Saikawa, T; Umeno, Y; Yoshimatsu, H, 2010) |
| "Risk of cancer is increased in conditions associated with insulin resistance, but this could be secondary to subclinical inflammation." | 1.36 | Insulin resistance-related biomarker clustering and subclinical inflammation as predictors of cancer mortality during 21.5 years of follow-up. ( Godsland, IF; Johnston, DG; Loh, WJ; North, BV, 2010) |
| "95 men aged 45-65, suffering from type 2 diabetes for 0." | 1.36 | [Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes]. ( Hurina, NM; Korpacheva-Zinych, OV; Shuprovych, AA, 2010) |
| "Preeclampsia is referred to as the "disease of the theories" because of the multiple hypotheses proposed to explain is occurrence." | 1.35 | Insulin resistance and C-reactive protein in preeclampsia. ( Kutlesić, R; Milosavljević, M; Popović, J; Stefanović, M; Tubić-Pavlović, A; Vukomanović, P, 2009) |
| "Uric acid was measured in 1570 plasma samples collected at mean gestational age of 8." | 1.35 | Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes. ( Catov, J; Gandley, RE; Laughon, SK; Provins, T; Roberts, JM, 2009) |
| "Insulin resistance was determined by the homeostasis model assessment (HOMA-IR)." | 1.35 | Uric acid: a surrogate of insulin resistance in older women. ( Chen, LK; Chiou, ST; Hwang, SJ; Lai, HY; Lin, MH, 2008) |
| "Insulin resistance was determined by using homeostasis model assessment (HOMA-IR)." | 1.34 | Ultrasonographic and biochemical evaluation of visceral obesity in obese women with non-alcoholic fatty liver disease. ( Akdag, B; Fenkci, S; Rota, S; Sabir, N, 2007) |
| "Insulin resistance was measured by homeostasis model assessment (HOMA)." | 1.33 | Serum resistin level among healthy subjects: relationship to anthropometric and metabolic parameters. ( Chen, CC; Li, CI; Li, TC; Lin, CC; Liu, CS; Wang, HJ, 2005) |
| "Hyperuricemia is associated with cardiovascular risk." | 1.33 | Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity. ( Fu, Y; Katsuya, T; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2005) |
| "Insulin resistance is a risk factors for non-alcoholic fatty liver disease (NAFLD) and for gallstone disease (GD)." | 1.33 | Gallstone disease in non-alcoholic fatty liver: prevalence and associated factors. ( Bertolotti, M; Carulli, L; Carulli, N; D'Amico, R; Ganazzi, D; Lombardini, S; Lonardo, A; Loria, P; Rudilosso, A; Verrone, A, 2005) |
| "Acute hyperinsulinemia was associated with higher urinary pH (6." | 1.32 | The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. ( Abate, N; Cabo-Chan, AV; Chandalia, M; Moe, OW; Sakhaee, K, 2004) |
| "Insulin resistance was estimated using the homeostasis model assessment (HOMA) method and the diagnosis of steatosis was determined by an ultrasound scan of the liver." | 1.32 | Insulin sensitivity and hepatic steatosis in obese subjects with normal glucose tolerance. ( Muggeo, M; Venturi, C; Zamboni, C; Zoppini, G, 2004) |
| "Insulin resistance was determined according to the Homeostasis Model Assessment (HOMA) formula." | 1.32 | Associations among sex hormone binding globulin concentrations and characteristics of the metabolic syndrome in obese women. ( Cikim, AS; Molvalilar, S; Orhan, Y; Ozbey, N; Sencer, E, 2004) |
| "In conclusion, hyperinsulinemia, as well as obesity, hyperuricemia, and hypertriglyceridemia were associated with hypertension in Japanese-Americans." | 1.31 | Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study. ( Egusa, G; Imazu, M; Kohno, N; Okubo, M; Sumii, K; Toyofuku, M; Yamakido, M; Yamamoto, H, 2001) |
| "Insulin resistance was estimated by homeostasis model assessment (HOMA(IR)), preliminarily validated against a euglycemic-hyperinsulinemic clamp in 85 subjects." | 1.30 | Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. ( Alberiche, M; Bonadonna, RC; Bonora, E; Egger, G; Kiechl, S; Muggeo, M; Oberhollenzer, F; Targher, G; Willeit, J, 1998) |
| "The insulin resistance is associated with a clustering of risk factors of cardiovascular disease, more cluste-ring, more resistant." | 1.30 | [The role of insulin resistance in the clustering of cardiovascular risk factors]. ( Guo, D; Xu, C, 1997) |
| "This may be a pathogenetic factor in preeclampsia and may contribute to the excess cardiovascular morbidity among women with prior preeclampsia." | 1.30 | Evidence of a state of increased insulin resistance in preeclampsia. ( Kaaja, R; Laakso, M; Laivuori, H; Tikkanen, MJ; Ylikorkala, O, 1999) |
| "Insulin resistance was assessed by a 75-g oral glucose tolerance test and homeostasis model assessment (HOMA)." | 1.30 | Insulin resistance and angiographical characteristics of coronary atherosclerosis. ( Arakawa, K; Saku, K; Shirai, K; Takezako, T; Zhang, B, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (1.42) | 18.7374 |
| 1990's | 41 (9.67) | 18.2507 |
| 2000's | 96 (22.64) | 29.6817 |
| 2010's | 191 (45.05) | 24.3611 |
| 2020's | 90 (21.23) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, AY | 1 |
| Roh, JG | 1 |
| Shim, YS | 1 |
| Lee, HS | 1 |
| Hwang, JS | 1 |
| Kalay Senturk, NG | 1 |
| Dagdeviren Cakir, A | 1 |
| Yildirmak, ZY | 1 |
| Ucar, A | 1 |
| Yu, W | 4 |
| Chen, C | 1 |
| Zhuang, W | 2 |
| Wang, W | 6 |
| Liu, W | 3 |
| Zhao, H | 3 |
| Lv, J | 2 |
| Wang, Q | 5 |
| He, F | 3 |
| Xu, C | 6 |
| Chen, B | 4 |
| Yamamoto, T | 12 |
| Koyama, H | 5 |
| Cheng, J | 6 |
| Tanaka, M | 3 |
| Takahashi, S | 4 |
| Higashiura, Y | 2 |
| Sakai, A | 2 |
| Koyama, M | 2 |
| Saitoh, S | 3 |
| Shimamoto, K | 3 |
| Ohnishi, H | 3 |
| Furuhashi, M | 3 |
| Sun, J | 2 |
| Sun, M | 2 |
| Su, Y | 1 |
| Li, M | 4 |
| Ma, S | 1 |
| Zhang, Y | 6 |
| Zhang, A | 1 |
| Cai, S | 1 |
| Cheng, B | 1 |
| Bao, Q | 1 |
| Zhu, P | 1 |
| Wang, S | 1 |
| Niu, Y | 1 |
| Tang, Q | 1 |
| Zhao, X | 2 |
| Mao, X | 1 |
| Sheng, J | 1 |
| Cai, W | 1 |
| Feng, Y | 1 |
| Fernández-Chirino, L | 1 |
| Antonio-Villa, NE | 1 |
| Fermín-Martínez, CA | 1 |
| Márquez-Salinas, A | 1 |
| Guerra, EC | 1 |
| Vargas-Vázquez, A | 1 |
| Almeda-Valdés, P | 1 |
| Gómez-Velasco, D | 1 |
| Viveros-Ruiz, TL | 1 |
| Rojas, R | 1 |
| Aguilar Salinas, CA | 1 |
| Bello-Chavolla, OY | 1 |
| Caimi, G | 1 |
| Urso, C | 1 |
| Brucculeri, S | 1 |
| Amato, C | 1 |
| Lo Presti, R | 1 |
| Carlisi, M | 1 |
| Akhigbe, RE | 1 |
| Oladipo, AA | 1 |
| Oyedokun, PA | 1 |
| Hamed, MA | 1 |
| Okeleji, LO | 1 |
| Ajayi, AF | 1 |
| Overberg, J | 1 |
| Kalveram, L | 1 |
| Keller, T | 1 |
| Krude, H | 1 |
| Kühnen, P | 1 |
| Wiegand, S | 2 |
| Petersen, KF | 1 |
| Dufour, S | 1 |
| Li, F | 4 |
| Rothman, DL | 1 |
| Shulman, GI | 1 |
| Wang, M | 5 |
| Rodriguez-Iturbe, B | 2 |
| Johnson, RJ | 13 |
| Lanaspa, MA | 6 |
| Nakagawa, T | 5 |
| Garcia-Arroyo, FE | 2 |
| Sánchez-Lozada, LG | 6 |
| Kahaer, M | 1 |
| Zhang, B | 2 |
| Chen, W | 3 |
| Liang, M | 1 |
| He, Y | 1 |
| Chen, M | 1 |
| Li, R | 1 |
| Tian, T | 1 |
| Hu, C | 1 |
| Sun, Y | 1 |
| Banik, SD | 1 |
| Avila-Nava, A | 1 |
| Lugo, R | 1 |
| Chim Aké, R | 1 |
| Gutiérrez Solis, AL | 1 |
| Fritz, J | 1 |
| Brozek, W | 1 |
| Concin, H | 1 |
| Nagel, G | 1 |
| Kerschbaum, J | 1 |
| Lhotta, K | 1 |
| Ulmer, H | 1 |
| Zitt, E | 1 |
| Coelho, MOC | 1 |
| Monteyne, AJ | 1 |
| Kamalanathan, ID | 1 |
| Najdanovic-Visak, V | 1 |
| Finnigan, TJA | 1 |
| Stephens, FB | 1 |
| Wall, BT | 1 |
| Sun, H | 4 |
| Chang, X | 1 |
| Bian, N | 1 |
| An, Y | 1 |
| Liu, J | 7 |
| Leng, S | 1 |
| Wang, G | 1 |
| Kanagasabai, T | 1 |
| Riddell, MC | 1 |
| Ardern, CI | 1 |
| Dilimulati, D | 1 |
| Chen, D | 1 |
| Cai, M | 1 |
| You, H | 1 |
| Gao, X | 1 |
| Shao, X | 1 |
| Zhang, M | 4 |
| Qu, S | 1 |
| Xilifu, D | 1 |
| Tuerxun, Z | 1 |
| Nuermaimaiti, B | 1 |
| Aili, A | 1 |
| Rehemu, N | 1 |
| Zhang, X | 4 |
| da Silva Júnior, JG | 1 |
| de Araújo, HDA | 1 |
| da Rocha, IG | 1 |
| da Silva Neto, JC | 1 |
| Oliveira, RN | 1 |
| de Oliveira Assis, SP | 1 |
| de Menezes Lima, VL | 1 |
| Maruszczak, K | 1 |
| Radzikowski, K | 1 |
| Schütz, S | 1 |
| Mangge, H | 3 |
| Bergsten, P | 1 |
| Forslund, A | 1 |
| Manell, H | 1 |
| Pixner, T | 1 |
| Ahlström, H | 1 |
| Kullberg, J | 1 |
| Mörwald, K | 1 |
| Weghuber, D | 2 |
| Lu, J | 2 |
| Yan, Y | 1 |
| Xi, Y | 1 |
| Yu, L | 1 |
| Zhang, C | 1 |
| Hu, Z | 1 |
| Zhi, X | 1 |
| Li, J | 3 |
| Li, B | 2 |
| Wang, J | 4 |
| Zhu, J | 2 |
| Zhang, Z | 2 |
| Krysiak, R | 8 |
| Kowalcze, K | 5 |
| Okopień, B | 8 |
| Son, DH | 1 |
| Ha, HS | 1 |
| Park, HM | 1 |
| Kim, HY | 1 |
| Lee, YJ | 2 |
| Basiak, M | 1 |
| Szkróbka, W | 2 |
| Genovesi, S | 2 |
| Tassistro, E | 1 |
| Giussani, M | 2 |
| Lieti, G | 1 |
| Patti, I | 1 |
| Orlando, A | 1 |
| Montemerlo, M | 1 |
| Antolini, L | 2 |
| Parati, G | 1 |
| Salehidoost, R | 1 |
| Taghipour Boroujeni, G | 1 |
| Feizi, A | 1 |
| Aminorroaya, A | 1 |
| Amini, M | 1 |
| Seong, JM | 1 |
| Gi, MY | 1 |
| Cha, JA | 1 |
| Sung, HH | 1 |
| Park, SY | 1 |
| Park, CH | 1 |
| Yoon, H | 1 |
| Gumus Balikcioglu, P | 3 |
| Jachthuber Trub, C | 3 |
| Balikcioglu, M | 3 |
| Ilkayeva, O | 3 |
| White, PJ | 3 |
| Muehlbauer, M | 3 |
| Bain, JR | 3 |
| Armstrong, S | 3 |
| Freemark, M | 3 |
| He, HM | 3 |
| Zhang, L | 4 |
| Qiu, N | 3 |
| Zhou, ZT | 3 |
| Zhang, K | 3 |
| Li, Y | 11 |
| Chen, HB | 3 |
| Xu, JN | 3 |
| Keskin, E | 2 |
| Yoldas Ilktac, H | 2 |
| El-Eshmawy, MM | 3 |
| Ibrahim, A | 2 |
| Bahriz, R | 2 |
| Shams-Eldin, N | 2 |
| Mahsoub, N | 3 |
| Tolan, DR | 2 |
| Bredesen, D | 1 |
| Nagel, M | 1 |
| Fini, M | 1 |
| Burtis, S | 1 |
| Perlmutter, D | 1 |
| Primo, D | 1 |
| Izaola, O | 1 |
| de Luis, D | 1 |
| Kashiwagi, Y | 1 |
| Nagoshi, T | 1 |
| Kimura, H | 1 |
| Tanaka, Y | 1 |
| Oi, Y | 1 |
| Inoue, Y | 1 |
| Ogawa, K | 1 |
| Kawai, M | 1 |
| Yoshimura, M | 1 |
| Li, HF | 1 |
| Miao, X | 1 |
| González-Domínguez, Á | 1 |
| Belmonte, T | 1 |
| Domínguez-Riscart, J | 1 |
| Ruiz-Ocaña, P | 1 |
| Muela-Zarzuela, I | 1 |
| Saez-Benito, A | 1 |
| Montañez-Martínez, R | 1 |
| Mateos, RM | 1 |
| Lechuga-Sancho, AM | 1 |
| Singh, SK | 2 |
| Singh, R | 1 |
| Iquebal, MA | 1 |
| Jaiswal, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Chronic Mycoprotein Consumption, and of Its Nucleotide Content, in Uric Acid Concentrations and Other Markers of Metabolic Health in Adults[NCT02984358] | 30 participants (Actual) | Interventional | 2017-01-31 | Completed | |||
| The Bogalusa Heart Study[NCT00005129] | 11,737 participants (Actual) | Observational | 1972-06-30 | Active, not recruiting | |||
| Study for the Investigation of New Individual Risk Profiles and Therapeutic Strategies in Obesity Related Cardiovascular and Metabolic Disorders.[NCT00482924] | 1,500 participants (Anticipated) | Observational | 2003-01-31 | Recruiting | |||
| Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage[NCT04752293] | 125 participants (Anticipated) | Observational | 2021-05-19 | Recruiting | |||
| The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men[NCT01050140] | 32 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| Genetic-specific Effects of Fructose on Liver Lipogenesis[NCT03783195] | 15 participants (Actual) | Interventional | 2019-01-25 | Completed | |||
| "Evaluation of the Intervention Program Obeldicks for Obese Children and Adolescents"[NCT00435734] | 4,000 participants (Actual) | Observational | 1999-07-31 | Active, not recruiting | |||
| The Effect of Acute Fructose Load in Patients With Chronic Kidney Disease and Patients With Type 2 Diabetes Compared to Healthy Subjects[NCT03157960] | 20 participants (Actual) | Interventional | 2012-02-01 | Completed | |||
| Comparative Study Evaluating the Outcome of Febuxostat Versus Vitamin E in Hyperuricemia Patients With Non-alcoholic Steatohepatitis Without Cirrhosis[NCT05574036] | Phase 2 | 70 participants (Anticipated) | Interventional | 2022-08-25 | Recruiting | ||
| Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | ||
| Optimal Macronutrient Intake - Carbohydrate[NCT00608049] | 189 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| The Effect of Dietary Fructose on Gut Microbiota and Hepatosteatosis in Healthy Men[NCT04898621] | 58 participants (Actual) | Interventional | 2021-06-01 | Completed | |||
| Alkaline Diet for Insulin Sensitivity[NCT02501343] | 32 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| A Three Arms, Randomized, Double-blind Controlled Trial of the Efficacy of Amway Uric Acid Lowering Product on Hyperuricemia[NCT06084585] | 180 participants (Anticipated) | Interventional | 2023-10-23 | Recruiting | |||
| Glucose Optimisation With Angiotensin II Antagonist Losartan in Patients With Hypertension and Other Risk Factors for Metabolic Syndrome (GOAAL)[NCT00237588] | Phase 4 | 25 participants | Interventional | 2004-12-31 | Completed | ||
| Uric Acid and Hypertension in African Americans[NCT00241839] | Phase 3 | 150 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| [NCT00005282] | 0 participants | Observational | 1981-12-31 | Completed | |||
| Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504] | Phase 4 | 25 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Omentectomy for Treatment of Diabetes Mellitus Type 2[NCT00270439] | Phase 1 | 10 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Phase 4 Study of the Effects of Pravastatin on Cholesterol Levels, Inflammation and Cognition in Schizophrenia[NCT01082588] | Phase 4 | 60 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| STimulating ImProved Health And Well-being In CysTic Fibrosis Using Integration Of Fitness Technology and Port CF.[NCT04018495] | 21 participants (Actual) | Interventional | 2019-09-10 | Completed | |||
| Effects of Fenofibrate on Metabolic and Reproductive Parameters in Polycystic Ovary Syndrome. A Randomized, Double-Blind, Placebo-Controlled Trial[NCT00884819] | 4 participants (Actual) | Interventional | 2008-12-31 | Terminated (stopped due to Poor recruitment) | |||
| The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids[NCT00184899] | 20 participants | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 3.44 |
| B (Placebo) | -0.83 |
Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | -5.9 |
| B (Placebo) | 0.90 |
"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 0.21 |
| B (Placebo) | -0.95 |
Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)
| Intervention | mg/dl (Mean) |
|---|---|
| A (Allopurinol) | 2.29 |
| B (Placebo) | 0.14 |
A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | g (Mean) |
|---|---|
| Ramelteon | 3934.86 |
| Placebo (Sugar Pill) | 5120.92 |
A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | HOMA score (Mean) |
|---|---|
| Ramelteon | 2.4 |
| Placebo (Sugar Pill) | 2.36 |
A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | cm (Mean) |
|---|---|
| Ramelteon | 106.09 |
| Placebo (Sugar Pill) | 108.37 |
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/L (Mean) |
|---|---|
| Pravastatin | 0.8063 |
| Placebo | -0.5136 |
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/dl (Mean) |
|---|---|
| Pravastatin | -25.565 |
| Placebo | -2.913 |
"The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery measures cognitive functioning within 7 domains: speed of processing, attention/vigilance, working memory (non verbal and verbal), verbal learning, visual learning, reasoning and problem solving and social cognition.~The composite score is calculated by the MATRICS computer program, which equally weights each of the 7 domain scores. The range of composite scores is 20-80. Higher scores indicate higher levels or cognitive functioning, while lower scores indicate lower levels of cognitive functioning." (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | 4.0417 |
| Placebo | 4.125 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 15-105. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -5.625 |
| Placebo | -3.76 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -0.83 |
| Placebo | -0.28 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -2.9583 |
| Placebo | -2.44 |
The Positive and Negative Syndrome Scale (PANSS) is a scale used to rate severity of schizophrenia. All items are summed to calculate the total score. The scale range is 30-210. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -9.416 |
| Placebo | -6.48 |
54 reviews available for uric acid and Insulin Sensitivity
| Article | Year |
|---|---|
Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis.
Topics: Fructose; Humans; Insulin Resistance; NAD; Sirtuins; Uric Acid | 2022 |
New markers in metabolic syndrome.
Topics: Adipokines; Alkaline Phosphatase; Biomarkers; Diabetes Mellitus, Type 2; Humans; Inflammation; Insul | 2022 |
Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond.
Topics: Endothelial Cells; Humans; Hyperuricemia; Insulin; Insulin Resistance; Uric Acid | 2023 |
Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?
Topics: Alzheimer Disease; Fructose; Glucose; Humans; Insulin Resistance; Uric Acid | 2023 |
Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions.
Topics: Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, LDL; Dietary Sugars; Fructo | 2020 |
Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age.
Topics: Cardiovascular Diseases; Child; Diabetes Mellitus; Fructose; Humans; Hypertension; Insulin Resistanc | 2020 |
Uric acid metabolism in polycystic ovary syndrome.
Topics: Female; Humans; Hyperuricemia; Insulin Resistance; Metabolic Syndrome; Polycystic Ovary Syndrome; Ur | 2021 |
Hyperuricemia-induced endothelial insulin resistance: the nitric oxide connection.
Topics: Animals; Endothelial Cells; Endothelium, Vascular; Humans; Hyperuricemia; Insulin Resistance; Nitric | 2022 |
Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials.
Topics: Blood Glucose; Blood Pressure; China; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Hyperurice | 2021 |
Effects of Sodium Glucose Cotransporter-2 Inhibitors on Serum Uric Acid in Type 2 Diabetes Mellitus.
Topics: Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hyperglycemia; Hyperuricemia; Hypoglyc | 2017 |
Uric Acid as a Cause of the Metabolic Syndrome.
Topics: AMP Deaminase; Animals; Diabetes Mellitus; Dietary Sugars; Fatty Liver; Fructose; Humans; Hypertensi | 2018 |
Metabolic syndrome and uric acid nephrolithiasis: insulin resistance in focus.
Topics: Humans; Insulin Resistance; Metabolic Syndrome; Nephrolithiasis; Prevalence; Risk Factors; Uric Acid | 2018 |
Effect of Uric Acid on Blood Glucose Levels.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Hyperuricemia; Insulin Resistance; Nitric Oxide; O | 2018 |
Failure to consider the menstrual cycle phase may cause misinterpretation of clinical and research findings of cardiometabolic biomarkers in premenopausal women.
Topics: Biomarkers; Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Female; Gonadal Steroid Horm | 2014 |
Sugar, uric acid, and the etiology of diabetes and obesity.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Sucrose; Disease Models, Animal | 2013 |
Fructose and uric acid: is there a role in endothelial function?
Topics: Cardio-Renal Syndrome; Endothelium, Vascular; Female; Fructose; Humans; Insulin Resistance; Male; Me | 2014 |
Xanthine oxidoreductase in atherosclerosis pathogenesis: not only oxidative stress.
Topics: Adipocytes; Animals; Atherosclerosis; Cardiovascular Diseases; Cell Differentiation; Cell Movement; | 2014 |
Uric acid as a modulator of glucose and lipid metabolism.
Topics: Animals; Glucose; Humans; Insulin Resistance; Lipid Metabolism; Liver; Metabolic Syndrome; Uric Acid | 2015 |
Serum uric acid: a new therapeutic target for nonalcoholic fatty liver disease.
Topics: Animals; Drug Design; Humans; Hyperuricemia; Inflammasomes; Insulin Resistance; Metabolic Syndrome; | 2016 |
Health implications of high-fructose intake and current research.
Topics: Animals; Diet; Dietary Sucrose; Fructose; Humans; Hypertension; Hypertriglyceridemia; Insulin; Insul | 2015 |
[Uric acid, kidney disease and nephrolithiasis].
Topics: Acid-Base Equilibrium; Gout; Humans; Hyperuricemia; Insulin Resistance; Kidney; Nephrolithiasis; Ren | 2016 |
Uric acid: A marker of increased cardiovascular risk.
Topics: Biomarkers; Cardiovascular Diseases; Carotid Artery Diseases; Coronary Artery Disease; Female; Heart | 2009 |
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Pressure; Evolution, Molecular; Fasting; Fructose; Gout; | 2009 |
Sugary drinks in the pathogenesis of obesity and cardiovascular diseases.
Topics: Adiposity; Animals; Beverages; Caffeine; Cardiovascular Diseases; Dietary Sucrose; Dogs; Fructose; H | 2008 |
Uric acid as a factor in the metabolic syndrome.
Topics: Biomarkers; Brazil; Cardiovascular Diseases; Female; Global Health; Humans; Hyperuricemia; Insulin R | 2010 |
Uric acid and the development of hypertension.
Topics: Animals; Cross-Sectional Studies; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Kidney; R | 2010 |
[Hyperuricemia and metabolic syndrome].
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Fructose; Humans; Hyperuricemia; Insulin Resistance | 2010 |
Diet-induced metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Biomarkers; Cardiovascular Diseases; Citric Acid; Die | 2011 |
[Relationship between metabolic syndrome and urinary stone disease].
Topics: Animals; Female; Humans; Insulin Resistance; Intra-Abdominal Fat; Life Style; Male; Metabolic Syndro | 2011 |
Beware the low urine pH--the major cause of the increased prevalence of nephrolithiasis in the patient with type 2 diabetes.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hydrogen-Ion Concentration; Insu | 2012 |
Cardiovascular and renal effects of hyperuricaemia and gout.
Topics: Biomarkers; Cardiovascular Diseases; Diabetes Complications; Disease Progression; Evidence-Based Med | 2012 |
[Renal affection in gout].
Topics: Creatinine; Gout; Humans; Hyperuricemia; Insulin Resistance; Kidney Diseases; Kidney Glomerulus; Pro | 2012 |
[Uric acid metabolism and insulin resistance in type 2 diabetes].
Topics: Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Humans; Hyperuricemia; Insulin Resista | 2002 |
[Idiopathic hyperuricemia].
Topics: Glyceraldehyde 3-Phosphate; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Insulin R | 2003 |
[Effect of hyperglycemia and insulin resistance on serum uric acid].
Topics: Adult; Blood Glucose; Glycosuria; Humans; Hyperglycemia; Hyperuricemia; Insulin; Insulin Resistance; | 2003 |
Novel insights into the pathogenesis of uric acid nephrolithiasis.
Topics: Circadian Rhythm; Glutamine; Humans; Hydrogen-Ion Concentration; Insulin Resistance; Kidney Diseases | 2004 |
[Hyperuricemia as a unique marker for metabolic syndrome].
Topics: Adipose Tissue; Arteriosclerosis; Biomarkers; Humans; Hyperuricemia; Insulin Resistance; Life Style; | 2005 |
Pathogenesis of gout.
Topics: Cardiovascular Diseases; Crystallization; Diet; Gout; Humans; Hyperuricemia; Inflammation; Insulin R | 2005 |
Uric acid and hypertension.
Topics: Humans; Hypertension; Hyperuricemia; Insulin Resistance; Uric Acid | 2005 |
Recent developments in diet and gout.
Topics: Beer; Feeding Behavior; Female; Food, Formulated; Gout; Humans; Insulin Resistance; Male; Metabolic | 2006 |
The conundrum of hyperuricemia, metabolic syndrome, and renal disease.
Topics: Animals; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Kidney; Metabolic Syndrome; Renal | 2008 |
The paradoxical relationship between serum uric acid and cardiovascular disease.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Heart Failure; Humans; Hypertension; Hyperuricemia; | 2008 |
[The metabolic syndrome. Pathophysiologic causes, diagnosis, therapy].
Topics: Arteriosclerosis; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Hyperinsulini | 1994 |
[Polymetabolic syndrome].
Topics: Albuminuria; Cholesterol; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypertension; Insulin; | 1995 |
[Hypertension and hyperuricemia].
Topics: Adolescent; Adult; Animals; Benzothiadiazines; Biological Transport; Calcium Channel Blockers; Cell | 1996 |
[Hyperuricemia and insulin resistance].
Topics: Cardiovascular Diseases; Cholesterol, HDL; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans | 1996 |
[Altered uric acid metabolism in diabetes mellitus].
Topics: Diabetes Mellitus; Humans; Insulin Resistance; Middle Aged; Uric Acid | 1997 |
The kidney: an unwilling accomplice in syndrome X.
Topics: Diabetes Mellitus, Type 2; Glucose; Homeostasis; Humans; Hyperinsulinism; Hypertension; Insulin; Ins | 1997 |
[Management of hyperuricemia in diabetes].
Topics: Allopurinol; Benzbromarone; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Human | 1997 |
[From type 2 diabetes to metabolic X syndrome].
Topics: Adult; Diabetes Mellitus, Type 2; Female; Humans; Hyperinsulinism; Insulin Resistance; Ischemia; Mal | 1999 |
[Insulin sensitizer and urate metabolism].
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Glucose; Gout; Humans; Hyperlipidemias; Hypertension; H | 2000 |
Insulin resistance: a chicken that has come to roost.
Topics: Coronary Disease; Diabetes Mellitus, Type 2; Fibrinolysis; Genotype; Humans; Hyperinsulinism; Hyperl | 1999 |
Uric acid as a risk factor for cardiovascular disease.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Female; Humans; Insulin Resistance; Ischemia; Male; Midd | 2000 |
[Renal markers and predictors, and renal and cardiovascular risk factors].
Topics: Age Factors; Alcohol Drinking; Biomarkers; Blood Pressure; Cardiovascular Diseases; Fatty Acids; Hum | 2002 |
38 trials available for uric acid and Insulin Sensitivity
| Article | Year |
|---|---|
High dietary nucleotide consumption for one week increases circulating uric acid concentrations but does not compromise metabolic health: A randomised controlled trial.
Topics: Adult; Blood Glucose; Diet; Humans; Insulin Resistance; Nucleotides; Postprandial Period; Uric Acid | 2022 |
Effects of long-term vitamin D supplementation on metabolic profile in middle-aged and elderly patients with type 2 diabetes.
Topics: Aged; Blood Glucose; C-Reactive Protein; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blin | 2023 |
Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial.
Topics: Biomarkers; Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Dietary Su | 2022 |
α-lipoic acid in patients with autosomal dominant polycystic kidney disease.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Blood Glucose; C-Reactive Protein; Caroti | 2020 |
Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes.
Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Body Mass Index; Diabetes Melli | 2021 |
Sagittal Abdominal Diameter does not Predict Metabolic Traits Better than Waist Circumference-Related Measures of Abdominal Obesity in Obese Subjects.
Topics: Abdomen; Adolescent; Adult; Aged; Body Mass Index; Female; Glycated Hemoglobin; Humans; Insulin; Ins | 2018 |
High intake of orange juice and cola differently affects metabolic risk in healthy subjects.
Topics: Adult; Blood Glucose; Body Weight; Carbonated Beverages; Citrus sinensis; Cross-Over Studies; Diet; | 2019 |
Interaction Between Lactate and Uric Acid is Associated With a Higher Prevalence of Metabolic Syndrome: A Community-Based Study.
Topics: Adult; C-Reactive Protein; China; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Lacti | 2019 |
High risk vs. "metabolically healthy" phenotype in juvenile obesity - neck subcutaneous adipose tissue and serum uric acid are clinically relevant.
Topics: Adiponectin; Adolescent; Carotid Artery Diseases; Child; Child, Preschool; Female; Humans; Insulin R | 2013 |
No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men.
Topics: Adenosine Triphosphate; Adolescent; Adult; Dietary Carbohydrates; Double-Blind Method; Energy Metabo | 2013 |
[Pre-diabetes mellitus influenced by hyperuricemia].
Topics: Adult; Aged; Female; Humans; Hyperuricemia; Insulin Resistance; Male; Middle Aged; Prediabetic State | 2013 |
Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia.
Topics: Adult; Aged; Allopurinol; Asymptomatic Diseases; Biomarkers; Female; Humans; Hyperuricemia; Inflamma | 2015 |
Effects of Lowering Glycemic Index of Dietary Carbohydrate on Plasma Uric Acid Levels: The OmniCarb Randomized Clinical Trial.
Topics: Adult; Black or African American; Blood Glucose; Cholesterol; Cholesterol, HDL; Cross-Over Studies; | 2016 |
The Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Antioxidants; Biomarkers; Blood Glucose; Body Weight; C-Reactive Protein; Diabetes Mell | 2016 |
Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Over Studies; Diabetes Mellitus, Type 2 | 2016 |
Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance.
Topics: Adolescent; Anthropometry; Beverages; Biomarkers; Child; Cross-Sectional Studies; Feeding Behavior; | 2016 |
Comparison of the effects of diets high in animal or plant protein on metabolic and cardiovascular markers in type 2 diabetes: A randomized clinical trial.
Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Dairy Products; Diabe | 2017 |
Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses.
Topics: Adolescent; Adult; Beverages; Blood Glucose; Body Mass Index; Cross-Over Studies; Diet; Eating; Fatt | 2009 |
Effect of moxonidine and amlodipine on serum YKL-40, plasma lipids and insulin sensitivity in insulin-resistant hypertensive patients-a randomized, crossover trial.
Topics: Adipokines; Adult; Amlodipine; Antihypertensive Agents; Biomarkers; Blood Pressure; Body Size; Chiti | 2010 |
Insulin resistance in non-obese women with polycystic ovary syndrome: relation to byproducts of oxidative stress.
Topics: Adult; Antioxidants; Body Mass Index; Female; Humans; Insulin Resistance; Malondialdehyde; Oxidative | 2011 |
Clinical and biochemical indicators of homeostasis model assessment-estimated insulin resistance in postmenopausal women.
Topics: Blood Glucose; Female; Homeostasis; Humans; Insulin; Insulin Resistance; Middle Aged; Models, Theore | 2011 |
Effects of statin monotherapy versus statin plus ezetimibe combination on serum uric acid levels.
Topics: Adult; Aged; Anticholesteremic Agents; Azetidines; Cardiovascular Diseases; Drug Therapy, Combinatio | 2013 |
Effect of Diamel in patients with metabolic syndrome: a randomized double-blind placebo-controlled study.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Dietary Supplements; Double-Blind Method; Female; Human | 2013 |
Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial.
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Antioxidants; Aspartate Aminotransferases; | 2012 |
The effects of surgically removing subcutaneous fat on the metabolic profile and insulin sensitivity in obese women after large-volume liposuction treatment.
Topics: Adipose Tissue; Adult; Blood Glucose; Body Height; Body Mass Index; Body Weight; Cholesterol, LDL; F | 2002 |
Endothelial function, insulin sensitivity and inflammatory markers in hyperprolactinemic pre-menopausal women.
Topics: Adult; Blood Glucose; Bromocriptine; C-Reactive Protein; Cholesterol; Endothelium, Vascular; Estroge | 2003 |
[Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)].
Topics: Adult; Aged; Blood Glucose; Female; Follow-Up Studies; Gout; Humans; Hypoglycemic Agents; Insulin Re | 2005 |
Improved insulin sensitivity with the angiotensin II-receptor blocker losartan in patients with hypertension and other cardiovascular risk factors.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Bloo | 2006 |
Relationship between insulin resistance and low urinary pH in patients with gout, and effects of PPARalpha agonists on urine pH.
Topics: Bezafibrate; Biomarkers; Body Mass Index; Fenofibrate; Gout; Humans; Hydrogen-Ion Concentration; Hyp | 2007 |
Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance.
Topics: Adolescent; Adult; Aged; Blood Glucose; Cholesterol; Cholesterol, HDL; Female; Glucose Tolerance Tes | 2008 |
Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons.
Topics: Adult; Blood Glucose; Dose-Response Relationship, Drug; Estradiol; Female; Follow-Up Studies; Gonada | 2008 |
A comparison of the effects of low- and conventional-dose thiazide diuretic on insulin action in hypertensive patients with NIDDM.
Topics: Adult; Antihypertensive Agents; Bendroflumethiazide; Blood Glucose; Cross-Over Studies; Diabetes Mel | 1995 |
[Forestier disease and metabolism disorders. A prospective controlled study of 25 cases].
Topics: Adult; Aged; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Hyper | 1993 |
Effect of insulin on renal sodium and uric acid handling in essential hypertension.
Topics: Adult; Blood Pressure; Female; Humans; Hyperinsulinism; Hypertension; Insulin Resistance; Kidney; Ma | 1996 |
The effect of menopause on serum uric acid levels in non-obese healthy women.
Topics: Adult; Body Mass Index; Female; Humans; Insulin Resistance; Menopause; Middle Aged; Obesity; Referen | 1998 |
Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects.
Topics: Adult; Blood Glucose; Creatinine; Female; Humans; Hydrocortisone; Insulin; Insulin Resistance; Lipid | 2000 |
Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Glucose; Blood | 2000 |
Increased visceral fat accumulation further aggravates the risks of insulin resistance in gout.
Topics: Adult; Aged; Cluster Analysis; Creatinine; Eating; Gout; Humans; Insulin Resistance; Male; Middle Ag | 2001 |
332 other studies available for uric acid and Insulin Sensitivity
| Article | Year |
|---|---|
Biochemical predictors of metabolically unhealthy obesity in children and adolescents.
Topics: Adolescent; Child; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Obesity, Metabo | 2022 |
Assessment of Serum Spexin Levels in Obese Adolescents with Metabolic Syndrome Antecedents: Preliminary Results.
Topics: Adolescent; Child; Humans; Insulin; Insulin Resistance; Metabolic Syndrome; Pediatric Obesity; Uric | 2021 |
Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages.
Topics: Carrier Proteins; Heme Oxygenase-1; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; | 2022 |
Circulating level of fatty acid-binding protein 4 is an independent predictor of metabolic dysfunction-associated fatty liver disease in middle-aged and elderly individuals.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fatty Acid | 2022 |
Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.
Topics: Adult; Aged; Biomarkers; Blood Glucose; China; Cross-Sectional Studies; Female; Glucose; Humans; Hyp | 2022 |
Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents.
Topics: Adolescent; Body Mass Index; Child; Child, Preschool; Female; Humans; Insulin; Insulin Resistance; M | 2021 |
Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue.
Topics: Adipose Tissue; Female; Glucose Clamp Technique; Humans; Insulin Resistance; Intra-Abdominal Fat; Nu | 2022 |
Uric acid and uric acid/creatinine ratio and their correlations with the hemorheological determinants in subjects with subclinical carotid atherosclerosis.
Topics: Aged; Carotid Artery Diseases; Creatinine; Female; Humans; Hyperuricemia; Insulin Resistance; Male; | 2022 |
Upregulation of Uric Acid Production and Caspase 3 Signalling Mediates Rohypnol-Induced Cardiorenal Damage.
Topics: Adenosine Triphosphatases; Animals; Caspase 3; Flunitrazepam; Inflammation; Insulin Resistance; Male | 2022 |
Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity.
Topics: Adolescent; Child; Circadian Rhythm; Cross-Sectional Studies; Humans; Insulin Resistance; Melatonin; | 2022 |
Ethnic and sex differences in hepatic lipid content and related cardiometabolic parameters in lean individuals.
Topics: Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Huma | 2022 |
Autophagy protects against high uric acid-induced hepatic insulin resistance.
Topics: Animals; Autophagy; Insulin; Insulin Resistance; Mammals; Mice; Reactive Oxygen Species; Uric Acid | 2022 |
Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China.
Topics: China; Female; Glucose; Humans; Hyperuricemia; Insulin Resistance; Male; Obesity; Obesity, Abdominal | 2022 |
Association Between Low-Grade Inflammation and Hyperuricemia in Adults With Metabolic Syndrome in Yucatán, México.
Topics: Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; H | 2022 |
The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia.
Topics: Adult; Biomarkers; Blood Glucose; Body Mass Index; Glucose; Humans; Hypertension; Hyperuricemia; Ins | 2022 |
Adipose Tissue Insulin Resistance Is Positively Associated With Serum Uric Acid Levels and Hyperuricemia in Northern Chinese Adults.
Topics: Adipose Tissue; Adult; China; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Insulin; Insul | 2022 |
Inflammation, Oxidative Stress, and Antioxidant Micronutrients as Mediators of the Relationship Between Sleep, Insulin Sensitivity, and Glycosylated Hemoglobin.
Topics: Antioxidants; Bilirubin; C-Reactive Protein; Carotenoids; Diabetes Mellitus; Glycated Hemoglobin; Hu | 2022 |
Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Blood Glucose; Body Mass Index; Case- | 2022 |
Effects of rosuvastatin on serum glucose and insulin in hyperuricemic rats.
Topics: Animals; Blood Glucose; Hyperuricemia; Insulin; Insulin Resistance; Rats; Rats, Sprague-Dawley; Rosu | 2022 |
Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance.
Topics: Animals; Carboxymethylcellulose Sodium; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dyslipidemias; | 2022 |
Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease.
Topics: Adolescent; Child; Glucagon; Glucose; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Non- | 2022 |
Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway
Topics: AMP-Activated Protein Kinases; Animals; Cytokines; Diabetes Mellitus, Type 2; Fluorodeoxyglucose F18 | 2022 |
Cabergoline-Induced Hypoprolactinemia May Attenuate Cardiometabolic Effects of Atorvastatin: A Pilot Study.
Topics: Androgens; Atorvastatin; C-Reactive Protein; Cabergoline; Cardiovascular Diseases; Female; Fibrinoge | 2022 |
Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia.
Topics: Alopecia; Bromocriptine; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Fibrinogen; | 2023 |
Association of obesity phenotypes with left ventricular mass index and left ventricular hypertrophy in children and adolescents.
Topics: Child; Female; Humans; Hypertrophy, Left Ventricular; Hyperuricemia; Insulin Resistance; Male; Metab | 2022 |
Gender Difference in the Association of Hyperuricemia with Insulin Resistance and beta-cell Function in Nondiabetic Korean Adults: The 2019 Korea National Health and Nutrition Examination Survey.
Topics: Adult; Female; Humans; Hyperuricemia; Insulin Resistance; Male; Nutrition Surveys; Obesity; Republic | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H | 2023 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count.
Topics: Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leukocyte Count; Male; Neutrophi | 2022 |
Fructose consumption correlates with triglyceride-glucose index and glycemic status in healthy adults.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Fructose; Glucose; Humans; In | 2022 |
Fructose consumption correlates with triglyceride-glucose index and glycemic status in healthy adults.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Fructose; Glucose; Humans; In | 2022 |
Fructose consumption correlates with triglyceride-glucose index and glycemic status in healthy adults.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Fructose; Glucose; Humans; In | 2022 |
Fructose consumption correlates with triglyceride-glucose index and glycemic status in healthy adults.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Fructose; Glucose; Humans; In | 2022 |
Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women.
Topics: Androgens; Blood Glucose; Body Mass Index; Creatinine; Estradiol; Female; Follicle Stimulating Hormo | 2022 |
Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women.
Topics: Androgens; Blood Glucose; Body Mass Index; Creatinine; Estradiol; Female; Follicle Stimulating Hormo | 2022 |
Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women.
Topics: Androgens; Blood Glucose; Body Mass Index; Creatinine; Estradiol; Female; Follicle Stimulating Hormo | 2022 |
Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women.
Topics: Androgens; Blood Glucose; Body Mass Index; Creatinine; Estradiol; Female; Follicle Stimulating Hormo | 2022 |
Resistin/uric acid index as a marker of metabolic syndrome in females with obesity.
Topics: Adolescent; Body Mass Index; Cross-Sectional Studies; Female; Glucose; Humans; Insulin; Insulin Resi | 2023 |
Effects of angiotensin receptor-neprilysin inhibitor on insulin resistance in patients with heart failure.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2023 |
Autoimmune Thyroiditis Attenuates Cardiometabolic Effects of Cabergoline in Young Women With Hyperprolactinemia.
Topics: C-Reactive Protein; Cabergoline; Cardiovascular Diseases; Cholesterol; Creatinine; Female; Fibrinoge | 2023 |
Impact of Lisinopril on Cardiometabolic Risk Factors in Sisters of Women With Polycystic Ovary Syndrome.
Topics: Androgens; Body Mass Index; C-Reactive Protein; Cardiometabolic Risk Factors; Cardiovascular Disease | 2023 |
The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose; Humans; Insul | 2023 |
The Impact of Atorvastatin on Cardiometabolic Risk Factors in Sisters of Women with Polycystic Ovary Syndrome.
Topics: Androgens; Atorvastatin; C-Reactive Protein; Cardiometabolic Risk Factors; Cardiovascular Diseases; | 2023 |
Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance.
Topics: Case-Control Studies; Child; Diabetes Mellitus, Type 2; Humans; Inflammasomes; Inflammation; Insulin | 2023 |
Uric acid and diabetes mellitus: an update.
Topics: Animals; Diabetes Mellitus; Humans; Insulin Resistance; Uric Acid | 2023 |
[Value of C-peptide-based insulin resistance index for evaluating correlation between insulin resistance and serum uric acid level in individuals undergoing health examination].
Topics: C-Peptide; Humans; Insulin; Insulin Resistance; Retrospective Studies; Uric Acid | 2023 |
The role of high fat diet on serum uric acid level among healthy male first degree relatives of type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diet, High-Fat; Humans; Insulin; Insulin Resistance; Male; Obesity; Uric | 2023 |
Cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Adult; Biomarkers; C-Reactive Protein; Cardiometabolic Risk Factors | 2020 |
Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men.
Topics: Adult; Blood Pressure; Body Mass Index; C-Reactive Protein; Humans; Hypertension; Insulin Resistance | 2020 |
Changes Over Time in Uric Acid in Relation to Changes in Insulin Sensitivity, Beta-Cell Function, and Glycemia.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose Tolerance Te | 2020 |
Possible role of l-carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic-Fructose-supplemented rats.
Topics: Animals; Carnitine; Fructose; Hyperuricemia; Insulin Resistance; Liver; Male; Oxidative Stress; Rats | 2019 |
Vitamin D3 potentiates the renoprotective effects of vildagliptin in a rat model of fructose/salt-induced insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cholecalciferol; Creatinine; Dipeptidyl-Pepti | 2020 |
Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.
Topics: Allopurinol; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Febuxostat; Hyperuricemia | 2020 |
Blood glucose fluctuations detected by continuous glucose monitoring system in gout patients with normal glucose tolerance and the effect of urate-lowering therapy.
Topics: Adult; Aged; Allopurinol; Biomarkers; Blood Glucose; Blood Glucose Self-Monitoring; Down-Regulation; | 2020 |
Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Adipose Tissue, Beige; Adipose Tissue, White; Adult; Ani | 2020 |
The role of resistin on metabolic syndrome-induced erectile dysfunction and the possible therapeutic effect of Boldine.
Topics: Animals; Antioxidants; Aporphines; Blood Glucose; Blood Pressure; Disease Models, Animal; Erectile D | 2020 |
Suppression of uric acid and lactate production by sodium acetate ameliorates hepatic triglyceride accumulation in fructose-insulin resistant pregnant rats.
Topics: Animals; Antioxidants; Blood Glucose; Female; Fructose; Glucose Tolerance Test; Insulin Resistance; | 2020 |
The impact of atorvastatin on cardiometabolic risk factors in brothers of women with polycystic ovary syndrome.
Topics: Adult; Aged; Androgens; Anticholesteremic Agents; Atorvastatin; Blood Glucose; C-Reactive Protein; C | 2021 |
Sodium acetate prevents nicotine-induced cardiorenal dysmetabolism through uric acid/creatine kinase-dependent pathway.
Topics: Animals; Creatine Kinase; Glucose; Glucose Tolerance Test; Heart; Insulin Resistance; Kidney; Male; | 2020 |
Association between relative fat mass, uric acid, and insulin resistance in children with chronic kidney disease.
Topics: Adolescent; Body Mass Index; Cross-Sectional Studies; Humans; Hyperuricemia; Insulin Resistance; Obe | 2021 |
Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance.
Topics: Adult; Atherosclerosis; Biomarkers; C-Reactive Protein; Essential Hypertension; Female; Humans; Insu | 2020 |
Subclinical Heart Dysfunction in Relation to Metabolic and Inflammatory Markers: A Community-Based Study.
Topics: Asymptomatic Diseases; Atrial Function, Left; Belgium; Biomarkers; Blood Glucose; Echocardiography, | 2021 |
Serum C-X-C motif chemokine ligand 14 levels are associated with serum C-peptide and fatty liver index in type 2 diabetes mellitus patients.
Topics: Adiponectin; Age Factors; Aged; Alanine Transaminase; Biomarkers; Body Mass Index; C-Peptide; Chemok | 2021 |
Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study.
Topics: Adolescent; Alanine Transaminase; Anthropometry; Blood Glucose; Body Mass Index; Child; China; Chole | 2020 |
Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis.
Topics: Diabetes Mellitus, Type 2; Female; Genotype; Humans; Insulin Resistance; Male; Mendelian Randomizati | 2021 |
Uric acid, impaired fasting glucose and impaired glucose tolerance in youth with overweight and obesity.
Topics: Adolescent; Age Factors; Biomarkers; Blood Glucose; Child; Child, Preschool; Cross-Sectional Studies | 2021 |
Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration.
Topics: Adipose Tissue; Adiposity; Animals; Fish Oils; Fructose; Glucocorticoids; Glucose; Homeostasis; Huma | 2021 |
Identification of two novel subgroups in patients with diabetes mellitus and their association with clinical outcomes: A two-step cluster analysis.
Topics: Adult; Age of Onset; Aged; Body Mass Index; China; Cluster Analysis; Cohort Studies; Diabetes Compli | 2021 |
Association Between Total Bilirubin Levels and Cardio-Metabolic Risk Factors Related to Obesity.
Topics: Adult; Bilirubin; Body Mass Index; Cardiometabolic Risk Factors; Cardiovascular Diseases; Case-Contr | 2022 |
Analysis of the correlation between plasma coagulation factor VII, PAI-1, and uric acid with insulin resistance and macrovascular complications in elderly patients with type 2 diabetes.
Topics: Aged; Diabetes Mellitus, Type 2; Factor VII; Humans; Insulin Resistance; Plasminogen Activator Inhib | 2021 |
Insulin resistance surrogates and left ventricular hypertrophy in normotensive obese children.
Topics: Child; Cross-Sectional Studies; Humans; Hypertrophy, Left Ventricular; Insulin Resistance; Pediatric | 2021 |
Genetic Predisposition to Type 2 Diabetes and Insulin Levels Is Positively Associated With Serum Urate Levels.
Topics: Adult; Blood Glucose; Causality; Diabetes Mellitus, Type 2; Fasting; Female; Genetic Predisposition | 2021 |
Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota.
Topics: Animals; Diet, High-Fat; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Inflammation; Insulin; | 2021 |
The elevation of serum uric acid depends on insulin resistance but not fasting plasma glucose in hyperuricaemia.
Topics: Blood Glucose; Fasting; Humans; Hyperuricemia; Insulin Resistance; Uric Acid | 2022 |
Prolonged Changes in Hepatic Mitochondrial Activity and Insulin Sensitivity by High Fructose Intake in Adolescent Rats.
Topics: Alanine Transaminase; Animals; Body Composition; Ceramides; Diet, Carbohydrate Loading; Disease Mode | 2021 |
Phase angle association with metabolic profile in adults: A population-based study.
Topics: Blood Glucose; Body Mass Index; Cholesterol, HDL; Cross-Sectional Studies; Female; Humans; Insulin R | 2021 |
Assessing the Causal Relationships Between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization.
Topics: Adult; Aged; Female; Genetic Loci; Gout; Humans; Hyperuricemia; Insulin; Insulin Resistance; Male; M | 2021 |
The application value of serum 25(OH)D3, uric acid, triglyceride, and homeostasis model assessment of insulin resistance in male patients with hyperuricemia combined with hypogonadism.
Topics: Adult; Aged; Calcifediol; Humans; Hyperuricemia; Hypogonadism; Insulin Resistance; Male; Middle Aged | 2021 |
Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cells, Cultured; Glucose; Glucose Transporter Type 4; | 2021 |
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Topics: Animals; Blood Glucose; Body Weight; CARD Signaling Adaptor Proteins; Caspase 1; Chemokine CCL2; Cyt | 2021 |
Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication.
Topics: Female; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Male; Uric Acid; Xanthine Dehydroge | 2021 |
Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study.
Topics: Adult; Cohort Studies; Female; Humans; Hypertension; Insulin Resistance; Male; Middle Aged; Prospect | 2022 |
High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle?
Topics: Blood Pressure; Body Mass Index; Cardiometabolic Risk Factors; Child; Creatinine; Female; Humans; In | 2021 |
Combined oral contraceptive and nitric oxide synthesis inhibition synergistically causes cardiac hypertrophy and exacerbates insulin resistance in female rats.
Topics: Animals; Blood Pressure; C-Reactive Protein; Cardiomegaly; Contraceptives, Oral, Combined; Estradiol | 2017 |
Effects of Obex in Overweight and Obese Subjects With or Without Impaired Fasting Glucose: A Pilot Study.
Topics: Adult; Anti-Obesity Agents; Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol, HDL; Creati | 2017 |
Xanthine oxidoreductase activity is correlated with insulin resistance and subclinical inflammation in young humans.
Topics: Adiponectin; Adult; Body Mass Index; C-Reactive Protein; Chromatography, Liquid; Female; Humans; Inf | 2017 |
Insulin resistance and associated factors: a cross-sectional study of bank employees.
Topics: Adult; Blood Pressure; Brazil; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Insulin; | 2017 |
[The Preliminary Investigation of GLP-1 Receptor Agonist on Liver Steatosis in Obese Mice].
Topics: Animals; Diet, High-Fat; Exenatide; Fatty Liver; Glucagon-Like Peptide-1 Receptor; Insulin Resistanc | 2017 |
Indices of insulin resistance and glucotoxicity are not associated with bipolar disorder or major depressive disorder, but are differently associated with inflammatory, oxidative and nitrosative biomarkers.
Topics: Adult; Biomarkers; Bipolar Disorder; Blood Glucose; Body Mass Index; C-Reactive Protein; Cross-Secti | 2017 |
Chicken or the Egg? Hyperuricemia, Insulin Resistance, and Hypertension.
Topics: Humans; Hypertension; Hyperuricemia; Insulin Resistance; Uric Acid | 2017 |
Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure Determination; China; Cohort Studies; Female; Humans; Hyp | 2017 |
Influence of weight status on 24-hour urine composition in adults without urolithiasis: A nationwide study based on a Chinese Han population.
Topics: Adult; Body Mass Index; Body Weight; Calcium; China; Citric Acid; Humans; Insulin Resistance; Logist | 2017 |
Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity.
Topics: Adolescent; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Child; Female; Humans; Insuli | 2017 |
Understanding the Impact of Added Sugar Consumption on Risk for Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Dietary Sucrose; Fructose; Humans; Insulin Resistance; Lipogenesis; Nutri | 2016 |
Effects of experimental periodontitis on the metabolic system in rats with diet-induced obesity (DIO): an analysis of serum biochemical parameters.
Topics: Alanine Transaminase; Alveolar Bone Loss; Animals; Aspartate Aminotransferases; Biomarkers; Blood Gl | 2018 |
Higher serum uric acid is associated with higher lumbar spine bone mineral density in male health-screening examinees: a cross-sectional study.
Topics: Alcoholism; Ascorbic Acid; Body Mass Index; Bone Density; C-Reactive Protein; Calcium; Cross-Section | 2019 |
Uric Acid Renal Lithiasis: New Concepts.
Topics: Ammonia; Humans; Hydrogen-Ion Concentration; Hyperuricemia; Insulin Resistance; Nephrolithiasis; Ris | 2018 |
Clinical Significance of Serum Uric Acid Levels in Mexican Young Adults.
Topics: Adolescent; Adult; Cholesterol, LDL; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Hu | 2018 |
The link between insulin resistance parameters and serum uric acid is mediated by adiposity.
Topics: Adiposity; Biomarkers; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Female; Glycated Hem | 2018 |
Serum uric acid to creatinine ratio correlates with β-cell function in type 2 diabetes.
Topics: Biomarkers; Creatinine; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glucose Tolerance Test | 2018 |
Hyperuricaemia and type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Humans; Hyperuricemia; Insulin; Insulin Resistance; Uric Acid | 2018 |
Longitudinal Associations of Metabolic Syndrome Severity Between Childhood and Young Adulthood: The Bogalusa Heart Study.
Topics: Adolescent; Adult; Aging; Alabama; Black People; Cardiovascular Diseases; Child; Cross-Sectional Stu | 2018 |
Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients.
Topics: Adult; Blood Glucose; Body Mass Index; Calcium; Case-Control Studies; Creatinine; Fasting; Female; F | 2018 |
Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score.
Topics: Adult; Age Factors; Aged; Biomarkers; Blood Glucose; C-Reactive Protein; Confounding Factors, Epidem | 2018 |
Adiponectin expression in visceral adiposity is an important determinant of insulin resistance in morbid obesity.
Topics: Adiponectin; Adult; Cross-Sectional Studies; Female; Gene Expression Regulation; Humans; Insulin Res | 2018 |
Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity.
Topics: Adolescent; Age of Onset; Anthropometry; Blood Pressure; Child; Child, Preschool; Cholesterol; Femal | 2018 |
Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation.
Topics: Animals; Blood Glucose; Blood Pressure; Carotenoids; Diosmin; Drug Therapy, Combination; Glycation E | 2018 |
[Serum Uric Acid and Islet β-cell Function in Patients with Pre-diabetes and Type 2 Diabetes Mellitus].
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Insulin; Insulin R | 2018 |
Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals.
Topics: Adult; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Female; Glomerular Filtration Rate; Gluco | 2018 |
Shall we diagnose metabolic syndrome in adolescents?
Topics: Adolescent; Biomarkers; Blood Glucose; Body Mass Index; Cholesterol, HDL; Female; Humans; Insulin Re | 2018 |
Untargeted Profiling of Concordant/Discordant Phenotypes of High Insulin Resistance and Obesity To Predict the Risk of Developing Diabetes.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Diglycerides; Fatty Acids, Unsaturated; Humans; Insulin Resis | 2018 |
Uric acid is linked to cardiometabolic risk factors in overweight and obese youths.
Topics: Adolescent; Anthropometry; Blood Pressure; Blood Pressure Determination; Body Mass Index; Cardiovasc | 2018 |
Laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass in the treatment of type 2 diabetes mellitus of patients with body mass index higher than 27.5 kg/m2 but lower than 32.5 kg/m2.
Topics: Adult; Bariatric Surgery; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Female; Humans; | 2018 |
Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities.
Topics: Adenosine Deaminase; Androgen Receptor Antagonists; Animals; Animals, Newborn; Antioxidants; Female; | 2018 |
Sodium acetate improves disrupted glucoregulation and hepatic triglyceride content in insulin-resistant female rats: involvement of adenosine deaminase and dipeptidyl peptidase-4 activities.
Topics: Adenosine Deaminase; Animals; Dipeptidyl Peptidase 4; Drug Combinations; Ethinyl Estradiol; Female; | 2019 |
Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements.
Topics: Adiponectin; Alanine Transaminase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Analysis of Varian | 2018 |
Salivary markers of hepato-metabolic comorbidities in pediatric obesity.
Topics: Adolescent; Biomarkers; Child; Comorbidity; Female; Glucose; Homeostasis; Humans; Insulin; Insulin R | 2019 |
Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by suppressing uric acid.
Topics: Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Female; Insulin Resistance; Liv | 2019 |
Dietary patterns and non-alcoholic fatty liver disease in a Greek case-control study.
Topics: Adult; C-Reactive Protein; Case-Control Studies; Diet; Diet Surveys; Feeding Behavior; Female; Greec | 2019 |
Cardiometabolic risk factors in young women with macroprolactinaemia.
Topics: Adult; Cardiovascular Diseases; Cholesterol, LDL; Female; Fibrinogen; Humans; Insulin Resistance; Mi | 2019 |
The Association between Serum Uric Acid Levels and Insulin Resistance and Secretion in Prediabetes Mellitus: A Cross-Sectional Study.
Topics: Cross-Sectional Studies; Female; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Insulin; Insul | 2019 |
Independent association of plasma xanthine oxidoreductase activity with serum uric acid level based on stable isotope-labeled xanthine and liquid chromatography/triple quadrupole mass spectrometry: MedCity21 health examination registry.
Topics: Aged; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Humans; Insulin Resista | 2020 |
Glutamine confers renoprotection by normalizing lipid and glutathione content in insulin-resistant pregnant rats.
Topics: Adenosine Deaminase; Animals; Female; Fructose; Glutamine; Glutathione; Insulin Resistance; Lipids; | 2019 |
Sodium butyrate recovers high-fat diet-fed female Wistar rats from glucose dysmetabolism and uric acid-associated cardiac tissue damage.
Topics: Animals; Antioxidants; Body Weight; Butyric Acid; Diet, High-Fat; Female; Glucose; Glucose Tolerance | 2019 |
Oral ethinylestradiol-levonorgestrel normalizes fructose-induced hepatic lipid accumulation and glycogen depletion in female rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Dose-Response Relationship, Drug; Drug C | 2019 |
The association between uric acid and chronic kidney disease in Korean men: a 4-year follow-up study.
Topics: Adult; Age Factors; Alcohol Drinking; Asian People; Blood Pressure; Body Mass Index; Cohort Studies; | 2013 |
Body mass index, waist circumference, and waist-to-height ratio as predictors of cardiometabolic risk in childhood obesity depending on pubertal development.
Topics: Adolescent; Body Height; Body Mass Index; Cardiovascular Diseases; Child; Female; gamma-Glutamyltran | 2013 |
Serum uric acid and blood pressure in children at cardiovascular risk.
Topics: Adolescent; Age Factors; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Child; Cohort Stu | 2013 |
Serum potassium level is associated with metabolic syndrome: a population-based study.
Topics: Aged; Asian People; Blood Glucose; Body Mass Index; China; Cholesterol, HDL; Cholesterol, LDL; Cross | 2014 |
Relationship between uric acid and arterial stiffness in the elderly with metabolic syndrome components.
Topics: Aged; Aged, 80 and over; Body Mass Index; Brachial Artery; Cholesterol, HDL; Female; Humans; Insulin | 2013 |
Dimethyl dimethoxy biphenyl dicarboxylate attenuates hepatic and metabolic alterations in high fructose-fed rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Blood Glu | 2016 |
Components of the metabolic syndrome are negative predictors of weight loss in obese children with lifestyle intervention.
Topics: Adolescent; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Child; Female; | 2014 |
Antioxidant profile of salivary glands in high fat diet-induced insulin resistance rats.
Topics: Animals; Antioxidants; Catalase; Diet, High-Fat; Insulin Resistance; Male; Parotid Gland; Peroxidase | 2014 |
Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects.
Topics: Antioxidants; Female; Humans; Insulin Resistance; Male; Middle Aged; Obesity; Oxidative Stress; Uric | 2014 |
Contribution of visceral fat accumulation and adiponectin to the clustering of metabolic abnormalities in a Japanese population.
Topics: Adiponectin; Adult; Alanine Transaminase; Blood Glucose; Cholesterol, HDL; Cluster Analysis; Female; | 2014 |
Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis.
Topics: Animals; Arterial Pressure; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Human Umbilical Ve | 2014 |
Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Fructose; Hypertension; Insul | 2014 |
Serum uric acid is associated with arterial stiffness in men with newly diagnosed type 2 diabetes mellitus.
Topics: Adult; Age Factors; Atherosclerosis; C-Reactive Protein; Carotid Arteries; China; Cross-Sectional St | 2014 |
Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids.
Topics: AMP Deaminase; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Europe; Gene | 2014 |
High uric acid directly inhibits insulin signalling and induces insulin resistance.
Topics: Acetylcysteine; Animals; Antioxidants; Disease Models, Animal; Glucose Intolerance; Hep G2 Cells; Hu | 2014 |
Effects of insulin resistance on left ventricular hypertrophy in patients with CKD stage 1-3.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; C-Re | 2014 |
Serum uric acid levels and metabolic syndrome.
Topics: Adolescent; Adult; Aged; Female; Humans; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; | 2014 |
Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension.
Topics: Adipose Tissue; Adult; Angiotensinogen; Body Mass Index; Case-Control Studies; China; Homeostasis; H | 2014 |
Oral fructose absorption in obese children with non-alcoholic fatty liver disease.
Topics: Adolescent; Biomarkers; Blood Glucose; Body Mass Index; Breath Tests; Child; Eating; Female; Fructos | 2015 |
The association between serum uric acid and residual β -cell function in type 2 diabetes.
Topics: Aged; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glucos | 2014 |
Comment on Fabbrini et al. Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes 2014;63:976-981.
Topics: Antioxidants; Female; Humans; Insulin Resistance; Male; Obesity; Oxidative Stress; Uric Acid | 2014 |
Response to Comment on Fabbrini et al. Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes 2014;63:976-981.
Topics: Antioxidants; Female; Humans; Insulin Resistance; Male; Obesity; Oxidative Stress; Uric Acid | 2014 |
Ursodeoxycholic acid ameliorates fructose-induced metabolic syndrome in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Fenofibrate; Fructose; Glutathione | 2014 |
[Insulin resistance and components of metabolic syndrome, analysis by gender and stage of adolescence].
Topics: Adipose Tissue; Adolescent; Age Factors; Blood Glucose; Body Mass Index; Child; Cholesterol; Dyslipi | 2014 |
Retinol-binding protein 4 as a novel risk factor for cardiovascular disease in patients with coronary artery disease and hyperinsulinemia.
Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies | 2014 |
Cardiometabolic Profile Related to Body Adiposity Identifies Patients Eligible for Bariatric Surgery More Accurately than BMI.
Topics: Adiposity; Adult; Bariatric Surgery; Body Mass Index; C-Reactive Protein; Female; Glycated Hemoglobi | 2015 |
[Relationship between vitamin D deficiency and metabolic syndrome in adult population of the Community of Madrid].
Topics: Adult; Aged; Anthropometry; Blood Glucose; Cross-Sectional Studies; Diet; Disease Susceptibility; Fe | 2015 |
Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients.
Topics: Adult; Female; Gout; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Kidney; Male; Middle A | 2015 |
Uric acid levels in patients with schizophrenia on clozapine monotherapy.
Topics: Adult; Anthropometry; Cardiovascular Diseases; Case-Control Studies; Clozapine; Female; Humans; Insu | 2015 |
Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder.
Topics: Adolescent; Adult; Aged; Atherosclerosis; Biomarkers; Bipolar Disorder; Blood Glucose; Body Mass Ind | 2015 |
Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Animals; Diet, High-Fat; Electrocardiography; Enz | 2015 |
[Metabolic complications of obesity during adolescence, particularly regarding elevated uric acid levels].
Topics: Adolescent; Biomarkers; Blood Pressure; Body Mass Index; Case-Control Studies; Child; Cross-Sectiona | 2015 |
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome.
Topics: Adult; Arginase; Blood Glucose; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Chol | 2016 |
Advanced oxidation protein products are more related to metabolic syndrome components than biomarkers of lipid peroxidation.
Topics: Adult; Advanced Oxidation Protein Products; Antioxidants; Biomarkers; Blood Glucose; C-Reactive Prot | 2015 |
[The role of uric acid in the insulin resistance in children and adolescents with obesity].
Topics: Adolescent; Blood Pressure; Body Height; Body Mass Index; Body Weight; Child; Cross-Sectional Studie | 2015 |
Circulating Levels of Uric Acid and Risk for Metabolic Syndrome.
Topics: Adult; Female; Humans; Hyperuricemia; Insulin Resistance; Male; Metabolic Syndrome; Mexico; Poverty; | 2017 |
Uric acid, carotid intima-media thickness and body composition in prepubertal children.
Topics: Biomarkers; Blood Pressure; Body Composition; Body Mass Index; C-Reactive Protein; Cardiovascular Di | 2016 |
Relationship between serum uric acid level and cardiometabolic risks in nondiabetic patients with schizophrenia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Cross-Sectional Stu | 2016 |
Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Albuminuria; Comorbidity; Cytokines; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 2015 |
Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism.
Topics: AMP-Activated Protein Kinases; Animals; Fatty Liver; Hep G2 Cells; Hepatocytes; Humans; Inflammasome | 2016 |
Vitamin D Status and Bone Mineral Density in Obese Children with Nonalcoholic Fatty Liver Disease.
Topics: Adolescent; Adult; Body Composition; Bone Density; C-Reactive Protein; Child; Female; Humans; Insuli | 2015 |
Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women.
Topics: Aged; Aging; Exercise Therapy; Female; Humans; Independent Living; Insulin Resistance; Japan; Middle | 2016 |
Fructose and glucose combined with free fatty acids induce metabolic disorders in HepG2 cell: A new model to study the impacts of high-fructose/sucrose and high-fat diets in vitro.
Topics: Cell Cycle; Cholesterol; Diet, High-Fat; Fatty Acids, Nonesterified; Fructokinases; Fructose; Glucos | 2016 |
Models Predictive of Metabolic Syndrome Components in Obese Pediatric Patients.
Topics: Adolescent; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Child; Cross-Sectional Studies; | 2016 |
High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo.
Topics: Animals; Cell Membrane; Cells, Cultured; Disease Models, Animal; Gene Expression; Glucose; Glucose T | 2016 |
Insulin resistance, body composition, and fat distribution in obese children with nonalcoholic fatty liver disease.
Topics: Abdominal Fat; Absorptiometry, Photon; Adolescent; Alanine Transaminase; Aspartate Aminotransferases | 2016 |
[The correlation between serum uric acid level and early-phase insulin secretion in subjects with normal glucose regulation].
Topics: Fasting; Glucose; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; | 2016 |
[Association of Insulin Resistance and β Cell Function with Lipid Metabolism in Middle-aged and Elderly Hui and Han Populations].
Topics: Aged; Asian People; Blood Glucose; Body Mass Index; Cholesterol; Ethnicity; Humans; Insulin; Insulin | 2016 |
Independent Link Between Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and FABP4 in a General Population Without Medication.
Topics: Age Factors; Aged; Alanine Transaminase; Aspartate Aminotransferases; Blood Urea Nitrogen; C-Reactiv | 2016 |
Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents: a cross-sectional study.
Topics: Adolescent; Alanine Transaminase; Blood Glucose; Body Mass Index; Case-Control Studies; Child; Chole | 2016 |
Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance.
Topics: Adenosine Monophosphate; Adenylate Kinase; Allosteric Site; AMP-Activated Protein Kinases; Animals; | 2016 |
Adiponectin: possible link between metabolic stress and oxidative stress in the elderly.
Topics: Adiponectin; Aged; Aging; Biomarkers; Case-Control Studies; Cholesterol, HDL; Female; Humans; Insuli | 2017 |
Association of serum calcium and heart failure with preserved ejection fraction in patients with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers; Blood Glucose; Calcium; China; Cross-Sectiona | 2016 |
Metabolic syndrome: prevalence and risk factors in Korean gout patients.
Topics: Adult; Aged; Female; Gout; Humans; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Preval | 2018 |
Effects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout.
Topics: Adult; Aged; C-Reactive Protein; Febuxostat; Female; Gout; Gout Suppressants; Humans; Insulin Resist | 2017 |
Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents.
Topics: Adolescent; Biomarkers; Body Mass Index; Child; Cross-Sectional Studies; Female; Humans; Insulin Res | 2017 |
Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults.
Topics: Aged; Biomarkers; China; Disease Susceptibility; Female; Humans; Insulin Resistance; Life Style; Mal | 2016 |
Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells.
Topics: 4-Chloro-7-nitrobenzofurazan; Acetylcysteine; Adenylate Kinase; Animals; Antioxidants; Cell Line; De | 2017 |
Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: Associations with inflammatory and oxidative stress biomarkers and uric acid.
Topics: Adult; Atherosclerosis; Biomarkers; C-Reactive Protein; Case-Control Studies; Depressive Disorder; F | 2017 |
Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.
Topics: Adolescent; Child; Female; Fructose; Humans; Insulin Resistance; Logistic Models; Male; Non-alcoholi | 2017 |
Co-associations between insulin sensitivity and measures of liver function, subclinical inflammation, and hematology.
Topics: Blood; Cluster Analysis; Cohort Studies; Coronary Disease; Cross-Sectional Studies; Diabetes Mellitu | 2008 |
Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults.
Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Female; Humans; Insulin Resistance | 2008 |
Role for the urinary bladder in pathogenesis of metabolic syndrome in Wistar rats.
Topics: Animals; Blood Glucose; Glucose; Insulin; Insulin Resistance; Metabolic Syndrome; Perfusion; Rats; R | 2008 |
Evaluation of antioxidant systems (coenzyme Q10 and total antioxidant capacity) in morbid obesity before and after biliopancreatic diversion.
Topics: Adult; Antioxidants; Benzothiazoles; Biliopancreatic Diversion; Blood Glucose; Cholesterol; Female; | 2008 |
Factors contributing to increased serum urate in postmenopausal Japanese females.
Topics: Adult; Aging; Alcohol Drinking; Body Mass Index; Female; Homeostasis; Humans; Insulin Resistance; Ja | 2009 |
Synergy between adiposity, insulin resistance, metabolic risk factors, and inflammation in adolescents.
Topics: Adolescent; Alanine Transaminase; Australia; C-Reactive Protein; Cardiovascular Diseases; Cholestero | 2009 |
Genome-wide linkage analysis for uric acid in families enriched for hypertension.
Topics: Chromosome Mapping; Chromosomes, Human, Pair 8; Cohort Studies; Creatinine; Female; Genetic Linkage; | 2009 |
Cardiovascular risk factors and not disease activity, severity or therapy associate with renal dysfunction in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; Dyslipidemias; Epidemiologic Methods; Fe | 2010 |
Do patients with uric acid stones exhibit abnormal circadian blood pressure--a hypothesis.
Topics: Blood Pressure; Body Mass Index; Circadian Rhythm; Humans; Hypertension; Insulin Resistance; Kidney | 2009 |
Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gout; Homeostasis; Hyperuricemia; Hypogl | 2009 |
Fructose ingestion: dose-dependent responses in health research.
Topics: Blood Glucose; Body Weight; Coronary Disease; Diabetes Mellitus, Type 2; Diet; Dose-Response Relatio | 2009 |
Patients with nephrolithiasis and blood hypertension have higher calciuria than those with isolated nephrolithiasis or hypertension?
Topics: Adolescent; Adult; Algorithms; Calcium; Case-Control Studies; Humans; Hypertension; Insulin Resistan | 2009 |
Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes.
Topics: Adolescent; Aging; Blood Glucose; Body Mass Index; Child; Cohort Studies; Diabetes Mellitus, Type 1; | 2009 |
[Peculiarities of uric acid balance disorders in patients with type 2 diabetes and metabolic syndrome].
Topics: Abdominal Fat; Aged; Diabetes Insipidus, Nephrogenic; Female; Humans; Hyperuricemia; Insulin Resista | 2009 |
[Effect of metformin on the clinical course of gout and insulin resistance].
Topics: Adult; Female; Gout; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; | 2009 |
Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women.
Topics: Adult; Birth Weight; Blood Glucose; Female; Fetal Growth Retardation; Humans; Hypertension, Pregnanc | 2009 |
Insulin resistance and C-reactive protein in preeclampsia.
Topics: Adult; Biomarkers; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Databases, Factual; Femal | 2009 |
Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes.
Topics: Body Mass Index; Diabetes, Gestational; Female; Humans; Hyperuricemia; Insulin Resistance; Logistic | 2009 |
Relationship between plasma uridine and urinary urea excretion.
Topics: Adult; Creatinine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Gout; Homeostasis; H | 2010 |
Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults.
Topics: Adult; Age Factors; Aged; Blood Glucose; Blood Pressure; Body Mass Index; Cities; Exercise; Fatty Li | 2010 |
Diabetic retinopathy is associated with visceral fat accumulation in Japanese type 2 diabetes mellitus patients.
Topics: Adiposity; Aged; Anthropometry; Blood Glucose; Blood Pressure; Body Composition; Body Mass Index; Di | 2010 |
Trp64Arg polymorphism of the ADRB3 gene predicts hyperuricemia risk in a population from southern Spain.
Topics: Adolescent; Adult; Aged; Alleles; Chi-Square Distribution; Cohort Studies; Female; Genetic Predispos | 2010 |
Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice.
Topics: Adipocytes; Administration, Oral; Animals; Aorta; Benzylamines; Blood Glucose; Cholesterol; Hydrogen | 2010 |
Angiotensin-converting enzyme gene polymorphism in overweight and obese Turkish patients with insulin resistance.
Topics: Adipose Tissue; Adult; Blood Glucose; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 2; Fe | 2010 |
Insulin resistance-related biomarker clustering and subclinical inflammation as predictors of cancer mortality during 21.5 years of follow-up.
Topics: Biomarkers; Blood Glucose; Cholesterol, HDL; England; Follow-Up Studies; Glucose Intolerance; Humans | 2010 |
Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis.
Topics: Adiposity; Adult; Aged; Arthritis, Gouty; Case-Control Studies; Female; Humans; Insulin Resistance; | 2011 |
Relevance of uric Acid in progression of type 2 diabetes mellitus.
Topics: Age Factors; Aged; Biomarkers; Blood Glucose; Bosnia and Herzegovina; Case-Control Studies; Diabetes | 2010 |
Clinical value of serum uric Acid in patients with suspected coronary artery disease.
Topics: Aged; Biomarkers; Coronary Angiography; Coronary Artery Disease; Female; Humans; Insulin Resistance; | 2010 |
Relationship between insulin resistance and inflamation markers in hemodialysis patients.
Topics: Albumins; Analysis of Variance; Biomarkers; Blood Glucose; C-Reactive Protein; Female; Fibrinogen; H | 2010 |
Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Cardiovascular Diseases; Chi-Square Distribution; Cholestero | 2010 |
Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins.
Topics: Adult; Biomarkers; Blood Pressure; California; Cross-Sectional Studies; Dyslipidemias; Fatty Liver; | 2010 |
Relationship between uric acid and metabolic syndrome according to menopausal status.
Topics: Adult; Aged; Blood Pressure; Cross-Sectional Studies; Female; Health Status; Humans; Hyperuricemia; | 2011 |
Differential relationships between anthropometry measures and cardiovascular risk factors in boys and girls.
Topics: Adolescent; Age Factors; Analysis of Variance; Anthropometry; Biomarkers; Blood Pressure; Body Heigh | 2011 |
Insulin resistance profile among siblings of type 2 diabetes mellitus (preliminary study).
Topics: Adult; Aged; Body Mass Index; Cholesterol, HDL; Cross-Sectional Studies; Diabetes Mellitus, Type 2; | 2010 |
Cystatin C, cardiometabolic risk, and body composition in severely obese children.
Topics: Adolescent; Alanine Transaminase; Analysis of Variance; Blood Glucose; Blood Pressure; Body Composit | 2011 |
Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation.
Topics: Adolescent; Biomarkers; Child; Female; Humans; Inflammation; Insulin Resistance; Male; Nitrates; Nit | 2011 |
[Metabolic syndrome and nephrolithiasis].
Topics: Animals; Calcium; Humans; Hydrogen-Ion Concentration; Insulin Resistance; Metabolic Syndrome; Nephro | 2011 |
[Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes].
Topics: Aged; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Testosteron | 2010 |
Factors associated with diabetic nephropathy in subjects with proliferative retinopathy.
Topics: Aged; Albuminuria; Blood Pressure; Blood Sedimentation; C-Reactive Protein; Circadian Rhythm; Diabet | 2012 |
[Disorders of uric acid metabolism in rats with fructose-induced experimental insulin resistance syndrome].
Topics: 5'-Nucleotidase; Adenosine Deaminase; Animals; Blood Glucose; Disease Models, Animal; Female; Fructo | 2011 |
Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals.
Topics: Adult; Ankle Brachial Index; Blood Glucose; Blood Pressure; Body Mass Index; C-Reactive Protein; Car | 2011 |
Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease.
Topics: Aged; Analysis of Variance; Blood Pressure Determination; Cohort Studies; Diet, Carbohydrate-Restric | 2012 |
Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress.
Topics: Adiponectin; Adult; Antioxidants; Biomarkers; Body Mass Index; C-Reactive Protein; Case-Control Stud | 2011 |
World congress on insulin resistance, diabetes, and cardiovascular disease: Part 1.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, T | 2011 |
The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes.
Topics: Biomarkers; Body Mass Index; C-Reactive Protein; China; Cross-Sectional Studies; Diabetes Mellitus; | 2011 |
Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis.
Topics: Aged; Blood Pressure; Diabetes Mellitus; Humans; Hydrogen-Ion Concentration; Hypertension; Insulin R | 2012 |
Optimal uric acid threshold to identify insulin resistance in healthy women.
Topics: Adult; Analysis of Variance; Argentina; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; | 2012 |
Serum uric acid and 1-h postload glucose in essential hypertension.
Topics: Adult; Blood Glucose; Cohort Studies; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glucos | 2012 |
Effect of body mass index-z score on adverse levels of cardiovascular disease risk factors.
Topics: Adiponectin; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Child; Female; Humans; Hy | 2012 |
Determinants of blood uric acid levels in a dyslipidemic Arab population.
Topics: Adult; Arabs; Body Mass Index; Chi-Square Distribution; Coronary Artery Disease; Cross-Sectional Stu | 2012 |
Triacylglycerols and body fat mass are possible independent predictors of C3 in apparently healthy young Brazilian adults.
Topics: Adipose Tissue; Adolescent; Adult; Anthropometry; Blood Pressure; Body Composition; Body Mass Index; | 2012 |
Melatonin improves metabolic syndrome induced by high fructose intake in rats.
Topics: Adipokines; Analysis of Variance; Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Di | 2012 |
Predictive ability of serum high-molecular-weight adiponectin in combination with serum insulin and serum C-reactive protein for the presence of metabolic syndrome.
Topics: Adiponectin; Adult; Alanine Transaminase; Biomarkers; C-Reactive Protein; gamma-Glutamyltransferase; | 2012 |
A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Fruc | 2013 |
Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.
Topics: Allopurinol; Animals; Blotting, Western; Carrier Proteins; Cholesterol; Creatinine; Dyslipidemias; F | 2012 |
Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats.
Topics: Animals; Ascorbic Acid; Blood Glucose; Body Weight; Catalase; Eating; Fructose; Glucose Tolerance Te | 2012 |
Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance.
Topics: Adult; Aged; Blood Glucose; Body Composition; Cholera Toxin; Glucose Tolerance Test; Haptoglobins; H | 2012 |
Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study.
Topics: Adolescent; Adult; Body Mass Index; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Female; | 2012 |
Pathological and behavioral risk factors for higher serum C-reactive protein concentrations in free-living adults--a Brazilian community-based study.
Topics: Abdominal Fat; Adult; Aged; Aged, 80 and over; Anthropometry; Blood Glucose; Body Mass Index; Brazil | 2013 |
Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey.
Topics: Adult; Aged; Aspartate Aminotransferases; Cholesterol, HDL; Cross-Sectional Studies; Fatty Liver; Fe | 2013 |
Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glucose; Humans; Insulin; Insulin Resistance; L | 2013 |
Serum uric acid as an independent predictor of mortality in high-risk patients with obstructive coronary artery disease: a prospective observational cohort study from the ET-CHD registry, 1997-2003.
Topics: Aged; Biomarkers; Cause of Death; Cohort Studies; Coronary Artery Disease; Female; Humans; Insulin R | 2013 |
Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk.
Topics: Adolescent; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Child; Choleste | 2013 |
Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women.
Topics: Adiponectin; Blood Glucose; Body Mass Index; Cardiovascular Diseases; Cholesterol; Female; Humans; I | 2012 |
[Plasma level of RBP4 in patients with coronary heart disease and the effect of hyperinsulinemia].
Topics: Adult; Aged; Case-Control Studies; Coronary Disease; Female; Humans; Hyperinsulinism; Insulin Resist | 2012 |
Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel.
Topics: Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Hyperuricemia; Insulin Resistance | 2012 |
Insulin resistance and metabolic syndrome in primary gout: relation to punched-out erosions.
Topics: Adult; Biomarkers; Case-Control Studies; Gout; Humans; Insulin; Insulin Resistance; Male; Metabolic | 2012 |
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats.
Topics: Animals; Beverages; Fatty Liver; Fructokinases; Fructose; Glucose; Hypertrophy; Hyperuricemia; Insul | 2013 |
Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population.
Topics: Adiponectin; Adult; Aged; Biomarkers; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, L | 2002 |
Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Pressure; Body Weight; Caloric Restriction; Chroma | 2002 |
Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (gamma-GTP) activity in non-drinkers.
Topics: Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Body Mass Index; Cholesterol; | 2002 |
Serum complement C3c concentration in non-obese young insulin-resistant Mexicans.
Topics: Adult; Blood Glucose; Body Mass Index; Complement C3c; Cross-Sectional Studies; Humans; Insulin; Ins | 2002 |
Prevalence and concomitants of glucose intolerance in European obese children and adolescents.
Topics: Adolescent; Birth Weight; Blood Glucose; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases | 2003 |
Hyperuricemia in hypothyroidism: is it associated with post-insulin infusion glycemic response?
Topics: Animals; Antithyroid Agents; Creatinine; Erythrocytes; Humans; Hyperuricemia; Hypothyroidism; Insuli | 2003 |
The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance.
Topics: Acids; Adult; Female; Humans; Hydrogen-Ion Concentration; Hyperinsulinism; Insulin Resistance; Kidne | 2004 |
Insulin sensitivity in Chinese ovo-lactovegetarians compared with omnivores.
Topics: Aged; Asian People; Blood Glucose; Blood Pressure; Body Mass Index; Buddhism; Dairy Products; Diet, | 2004 |
Adenosine deaminase activity in the serum of type 2 diabetic patients.
Topics: Adenosine Deaminase; Adult; Aged; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; In | 2004 |
[Insulin resistance syndrome in patients with gout and its influence on formation of clinical characteristics of the disease].
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Gout; Humans; | 2004 |
Is there any link between insulin resistance and inflammation in established preeclampsia?
Topics: Biomarkers; Case-Control Studies; Female; Humans; Inflammation; Inflammation Mediators; Insulin Resi | 2004 |
Insulin sensitivity and hepatic steatosis in obese subjects with normal glucose tolerance.
Topics: Adult; Alanine Transaminase; Blood Glucose; Body Mass Index; Cholesterol; Cohort Studies; Fatty Live | 2004 |
[Arterial hypertension in adolescents with different physical constitution including those with signs of metabolic syndrome].
Topics: Adolescent; Body Mass Index; Body Weights and Measures; Child; Cholesterol; Female; Glucose Toleranc | 2004 |
Serum resistin level among healthy subjects: relationship to anthropometric and metabolic parameters.
Topics: Adipose Tissue; Adult; Anthropometry; Blood Glucose; Blood Pressure; Body Composition; Body Height; | 2005 |
Elevated serum uric acid levels in gestational hypertension are correlated with insulin resistance.
Topics: Adult; Body Mass Index; Creatinine; Female; Homeostasis; Humans; Hypertension, Pregnancy-Induced; In | 2005 |
Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans.
Topics: Aged; Blood Glucose; Blood Pressure; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Female; | 2005 |
Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity.
Topics: Adult; Alleles; Asparagine; Gene Frequency; Genotype; Glycine; Homeostasis; Humans; Hyperuricemia; I | 2005 |
Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Female; Humans; Hypertension; Insulin Resistance; Male; | 2005 |
Relationships between human serum resistin, inflammatory markers and insulin resistance.
Topics: Biomarkers; Blood Glucose; Body Composition; Body Mass Index; C-Reactive Protein; Case-Control Studi | 2005 |
Gallstone disease in non-alcoholic fatty liver: prevalence and associated factors.
Topics: Age Factors; Apolipoproteins B; Biopsy; Cholecystolithiasis; Cholesterol; Fatty Liver; Female; Gallb | 2005 |
[Characteristics of metabolic syndrome in children and adolescents with arterial hypertension].
Topics: Adolescent; Body Mass Index; Child; Cholesterol, HDL; Cholesterol, LDL; Female; Glucose Intolerance; | 2005 |
Insulin resistance is not related to plasma homocysteine concentration in healthy premenapausal women.
Topics: Adolescent; Adult; Age Factors; Blood Glucose; Body Mass Index; Cholesterol, HDL; Female; Folic Acid | 2006 |
Associations among sex hormone binding globulin concentrations and characteristics of the metabolic syndrome in obese women.
Topics: Adult; Age Factors; Androstenedione; Blood Glucose; Blood Pressure; Body Mass Index; Case-Control St | 2004 |
Clustering of cardiovascular risk factors associated with the insulin resistance syndrome: assessment by principal component analysis in young hyperandrogenic women.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Fe | 2006 |
Type 2 diabetes increases the risk for uric acid stones.
Topics: Age Factors; Aged; Body Mass Index; Calcium; Diabetes Mellitus, Type 2; Female; Humans; Hydrogen-Ion | 2006 |
[An analysis of islet beta-cell function in hyperuricemia].
Topics: Adult; Aged; Female; Glucose Tolerance Test; Humans; Hyperuricemia; Insulin; Insulin Resistance; Ins | 2006 |
Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study.
Topics: Adiponectin; Adiposity; Adult; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseas | 2006 |
Synergistic effect of alcohol & fructose administration on blood urate & biochemical indices of insulin resistance in albino rabbits.
Topics: Animals; Blood Glucose; Ethanol; Fructose; Insulin Resistance; Male; Rabbits; Triglycerides; Uric Ac | 2006 |
Ultrasonographic and biochemical evaluation of visceral obesity in obese women with non-alcoholic fatty liver disease.
Topics: Adult; Age Factors; Alanine Transaminase; Aspartate Aminotransferases; Blood Glucose; Blood Pressure | 2007 |
High-density lipoprotein cholesterol and insulin resistance are independent and additive markers of left ventricular hypertrophy in essential hypertension.
Topics: Aged; Biomarkers; Blood Pressure Determination; Cholesterol, HDL; Female; Humans; Hypertension; Hype | 2007 |
Circadian variation in urine pH and uric acid nephrolithiasis risk.
Topics: Adolescent; Circadian Rhythm; Glucose; Humans; Hydrogen-Ion Concentration; Insulin Resistance; Male; | 2007 |
Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid.
Topics: Adult; Aged; Body Mass Index; Female; Humans; Insulin Resistance; Leptin; Lipoproteins, HDL; Male; M | 2007 |
Relationship between hyperuricemia and body fat distribution.
Topics: Adipose Tissue; Adult; Body Fat Distribution; Humans; Hyperuricemia; Insulin Resistance; Lipids; Mal | 2007 |
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Diuretics; Fructose; Gout Suppressants; Hydrochlo | 2007 |
Genome scan for determinants of serum uric acid variability.
Topics: Adult; Blood Pressure; Cardiovascular Diseases; Chromosome Mapping; Diabetes Mellitus, Type 2; Femal | 2007 |
Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Cholesterol, HDL; Humans; Hyperinsulinis | 2008 |
Uric acid: a surrogate of insulin resistance in older women.
Topics: Body Mass Index; Chronic Disease; Female; Glomerular Filtration Rate; Humans; Insulin Resistance; Ki | 2008 |
[A prospective study on relationship between blood uric acid levels, insulin sensitivity and insulin resistance].
Topics: Adult; China; Cohort Studies; Female; Humans; Insulin; Insulin Resistance; Logistic Models; Middle A | 2007 |
Diabetes and nephrolithiasis.
Topics: Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Nephrolithiasis; Prevalence; Uric Acid | 2007 |
Uric acid indicates a high cardiovascular risk profile but is not closely associated with insulin resistance in obese adolescents.
Topics: Adolescent; Cardiovascular Diseases; Humans; Insulin Resistance; Metabolic Syndrome; Obesity; Risk F | 2008 |
Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey.
Topics: Adult; Biomarkers; Blood Glucose; C-Peptide; Diet; Fasting; Female; Glycated Hemoglobin; Gout; Healt | 2008 |
[Correlation between serum uric acid and insulin resistance].
Topics: Adult; Blood Glucose; China; Female; Humans; Insulin; Insulin Resistance; Male; Metabolic Syndrome; | 2007 |
A decreased mitochondrial DNA content is related to insulin resistance in adolescents.
Topics: Adolescent; Blood Glucose; Cross-Sectional Studies; DNA-Binding Proteins; DNA, Mitochondrial; Down-R | 2008 |
Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Anthropometry; Body Constitution; Cohort St | 1995 |
Hyperuricaemia: relationships to body fat distribution and other components of the insulin resistance syndrome in 38-year-old healthy men and women.
Topics: Adipose Tissue; Adult; Blood Glucose; Body Composition; Body Constitution; Body Mass Index; Female; | 1995 |
Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women.
Topics: Apolipoprotein A-I; Apolipoprotein A-II; Case-Control Studies; Cholesterol; Epoprostenol; Female; Hu | 1995 |
Hyperuricemia and insulin resistance.
Topics: Adult; Aged; Blood Glucose; Fatty Acids, Nonesterified; Female; Humans; Insulin; Insulin Resistance; | 1994 |
Effect of maternal diabetes on the pattern of selected insulin resistance syndrome parameters in normal glucose tolerant subjects of two Algonquin Indian communities in Quebec.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, | 1996 |
Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study.
Topics: Adipose Tissue; Adolescent; Alcohol Drinking; Arteriosclerosis; Blood Pressure; Body Composition; Bo | 1996 |
Serum uric acid, insulin secretion and resistance in nonhyperuricemic and hyperuricemic obese female subjects.
Topics: Adult; C-Peptide; Female; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Insulin Secr | 1996 |
Normal serum uric acid concentrations in women with polycystic ovary syndrome.
Topics: Adult; Androstenedione; Body Mass Index; Female; Humans; Insulin; Insulin Resistance; Luteinizing Ho | 1996 |
The insulin resistance syndrome and postprandial lipid intolerance in smokers.
Topics: Adult; Apolipoprotein A-II; Apolipoproteins B; Blood Glucose; Body Mass Index; C-Peptide; Fibrinogen | 1997 |
Hyperinsulinemia in patients with coronary heart disease in absence of overt risk factors.
Topics: Adult; Aged; Anthropometry; Blood Glucose; Blood Pressure; C-Peptide; Comorbidity; Convalescence; Co | 1997 |
Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure.
Topics: Aged; Carbon Dioxide; Cardiomyopathy, Dilated; Chronic Disease; Energy Metabolism; Exercise Test; Fe | 1997 |
Relationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients.
Topics: Administration, Oral; Aged; Apolipoproteins; Biguanides; Blood Glucose; Blood Pressure; Body Constit | 1997 |
Does insulin resistance unite the separate components of the insulin resistance syndrome? Evidence from the Miami Community Health Study.
Topics: Adult; Anthropometry; Cholesterol, HDL; Cohort Studies; Comorbidity; Coronary Disease; Ethnicity; Fe | 1997 |
Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-based sample of 380 young healthy Caucasians.
Topics: Adult; Body Mass Index; Contraceptives, Oral; Fasting; Female; Humans; Insulin Resistance; Male; Ref | 1998 |
Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study. Coronary Artery Risk Development in Young Adults.
Topics: Adult; Black People; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Cross-Sectional Stu | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity.
Topics: Adult; Belgium; Body Mass Index; Body Weight; Cholesterol; Cholesterol, HDL; Cohort Studies; Comorbi | 1998 |
Hyperlipidaemia in hyperuricaemia and gout.
Topics: Gout; Humans; Hyperinsulinism; Hypertriglyceridemia; Insulin Resistance; Uric Acid | 1998 |
The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. 1956.
Topics: Adrenal Cortex Hormones; Androgens; Arteriosclerosis; Body Constitution; Cholelithiasis; Diabetes Me | 1999 |
Microalbuminuria and hypertension in nondiabetic Japanese men.
Topics: Adult; Aged; Albuminuria; Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus; Glucose Tole | 1999 |
Salt sensitivity correlates positively with insulin sensitivity in healthy volunteers.
Topics: Adult; Aged; Blood Pressure; Cholesterol, HDL; Female; Humans; Insulin; Insulin Resistance; Male; Mi | 1999 |
[The role of insulin resistance in the clustering of cardiovascular risk factors].
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; China; Cluster Analysis; Coronary Disease; Female; Hu | 1997 |
Contribution of a missense mutation (Trp64Arg) in beta3-adrenergic receptor gene to multiple risk factors in Japanese men with hyperuricemia.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Gout; Humans; Insulin Resistance; Japan; Male; Mid | 1998 |
Evidence of a state of increased insulin resistance in preeclampsia.
Topics: Adult; C-Peptide; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test; Humans; Insulin Resist | 1999 |
Insulin resistance and angiographical characteristics of coronary atherosclerosis.
Topics: Blood Pressure; Coronary Angiography; Coronary Artery Disease; Fibrinogen; Glucose Tolerance Test; H | 1999 |
Maternal effect of Type 2 diabetes mellitus on insulin sensitivity and metabolic profile in healthy young Mexicans.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Creatinin | 1999 |
Is carbohydrate metabolism altered among women who have undergone a preeclamptic pregnancy?
Topics: Adult; Androgens; Blood Glucose; Blood Pressure; Body Mass Index; Carbohydrate Metabolism; Fasting; | 1999 |
Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study.
Topics: Adult; Body Mass Index; Diet, Reducing; Dietary Fats, Unsaturated; Dietary Proteins; Follow-Up Studi | 2000 |
The potential role of adenosine in the pathophysiology of the insulin resistance syndrome.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adipose Tissue; Animals; Coronary Disease; | 2001 |
Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes.
Topics: Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female | 2001 |
Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Body Mass Index; Diabetes Mellitus; Fasti | 2001 |
Hyperinsulinemia and insulin resistance related metabolic syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Humans; Hyperglycemia; | 2001 |
Serum leptin in formerly small-for-gestational-age children during adolescence: relationship to gender, puberty, body composition, insulin sensitivity, creatinine, and serum uric acid.
Topics: Adolescent; Age Factors; Body Composition; Creatinine; Glucose Tolerance Test; Humans; Infant, Low B | 2001 |
Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study.
Topics: Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol; Female; Hawaii; Humans; Hyperinsulinism | 2001 |
Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study.
Topics: Case-Control Studies; Fatty Liver; Female; Humans; Insulin; Insulin Resistance; Logistic Models; Mal | 2002 |
Insulin resistance, hyperleptinemia, and obstructive sleep apnea in Launois-Bensaude syndrome.
Topics: Adult; Aged; Body Mass Index; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin Resistance; | 2002 |
[Various mechanisms of disorders of carbohydrate metabolism in myocardial infarct].
Topics: Acute Disease; Adult; Aged; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin | 1979 |
[Metabolic aspects of obesity].
Topics: Carbohydrate Metabolism; Fatty Acids; Humans; Insulin; Insulin Resistance; Obesity; Triglycerides; U | 1975 |
Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration.
Topics: Adult; Aged; Blood Glucose; Cholesterol, HDL; Cross-Sectional Studies; Female; Glucose; Humans; Insu | 1991 |
Elevated serum uric acid.
Topics: Female; Humans; Insulin; Insulin Resistance; Uric Acid | 1988 |
Elevated serum uric acid--a facet of hyperinsulinaemia.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Hu | 1987 |
Altered erythrocyte and plasma sodium and potassium in hypertension, a facet of hyperinsulinemia.
Topics: Erythrocytes; Female; Humans; Hyperinsulinism; Hypertension; Insulin Resistance; Longitudinal Studie | 1988 |
Metabolic effects in children of a 37 amino acid fragment of bovine growth hormone.
Topics: Adenoma, Chromophobe; Adolescent; Alkaline Phosphatase; Amino Acids; Blood Urea Nitrogen; Calcium; C | 1973 |