uric acid has been researched along with Injury, Myocardial Reperfusion in 29 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "By using a highly sensitive, high-performance liquid chromatographic technique, plasma values of malondialdehyde (MDA), adenosine and oxypurines were determined in 10 healthy subjects, 10 patients with noncardiac illness, and 20 patients with acute myocardial infarction (AMI) observed within 6 hours from the onset of symptoms." | 7.68 | Effectiveness of thrombolysis is associated with a time-dependent increase of malondialdehyde in peripheral blood of patients with acute myocardial infarction. ( Dagianti, A; Di Pierro, D; Fedele, F; Giardina, B; Lazzarino, G; Penco, M; Romano, S; Tavazzi, B, 1993) |
| " Severities of ischaemia (ST-segment elevation, inhomogeneity of electrical activation) and ventricular arrhythmias (VPBs, VT, VF), plasma nitrate/nitrite levels, as well as myocardial superoxide and nitrotyrosine productions were determined." | 3.77 | Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion? ( Juhász, L; Kaszaki, J; Kiss, A; Kovács, M; Nyeso, E; Seprényi, G; Végh, A, 2011) |
| "By using a highly sensitive, high-performance liquid chromatographic technique, plasma values of malondialdehyde (MDA), adenosine and oxypurines were determined in 10 healthy subjects, 10 patients with noncardiac illness, and 20 patients with acute myocardial infarction (AMI) observed within 6 hours from the onset of symptoms." | 3.68 | Effectiveness of thrombolysis is associated with a time-dependent increase of malondialdehyde in peripheral blood of patients with acute myocardial infarction. ( Dagianti, A; Di Pierro, D; Fedele, F; Giardina, B; Lazzarino, G; Penco, M; Romano, S; Tavazzi, B, 1993) |
| "A total of 101 (86." | 2.87 | Elevated serum uric acid affects myocardial reperfusion and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. ( Crimi, G; De Ferrari, GM; De Servi, S; Ferlini, M; Ferrario, M; Gianni, U; Leonardi, S; Mandurino-Mirizzi, A; Marinoni, B; Oltrona Visconti, L; Pica, S; Raineri, C; Repetto, A; Ruffinazzi, M, 2018) |
| "KO hearts showed a 41." | 1.72 | Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury. ( Aponte, A; Cockman, ME; Gucek, M; Harris, M; Keeran, K; Kennedy, LM; Murphy, E; Pirooznia, M; Singh, K; Springer, D; Sun, J, 2022) |
| "Uric acid is a purine degradation product but also an important antioxidant and reactive oxygen species (ROS) scavenger." | 1.56 | Human concentrations of uric acid scavenges adaptive and maladaptive reactive oxygen species in isolated rat hearts subjected to ischemic stress. ( Boardman, NT; Chu, X; Falck, AT; Jenssen, TG; Lund, T; Martin-Armas, M; Norvik, JV; Ytrehus, K, 2020) |
| "Uremia was induced by partial nephrectomy in male Wistar rats." | 1.38 | Preconditioning protects the heart in a prolonged uremic condition. ( Bencsik, P; Csonka, C; Csont, T; Ferdinandy, P; Kocsis, GF; Pálóczi, J; Pipicz, M; Sárközy, M; Varga, ZV, 2012) |
| " However, the concomitant production of superoxide and other reactive oxygen species (ROS) during I/R may diminish the bioavailability of NO and hence compromise the beneficial effects." | 1.33 | Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol. ( Colantuono, G; Khan, M; Kumbala, D; Kuppusamy, P; Kutala, VK; Mandal, R; Potaraju, V, 2006) |
| "Carvedilol pretreated patients had higher amount of serum UA (p<0." | 1.33 | Elevated serum uric acid reduce heart damage in patients undergoing opern-heart surgery. ( Blagojevć, D; Davidović, B; Kastratović, D; Mijalković, D; Nikolić, A; Spasić, M, 2006) |
| "Xanthine dehydrogenase was converted to xanthine oxidase during reperfusion and the activity of both enzymes were inhibited by allopurinol." | 1.28 | Purine and oxypurine production in mitochondria of ischemic and reperfused myocardium. ( Barnard, HC; Barnard, SP; Maartens, JJ; Potgieter, GM; van Jaarsveld, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 13 (44.83) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Harris, M | 1 |
| Sun, J | 1 |
| Keeran, K | 1 |
| Aponte, A | 1 |
| Singh, K | 1 |
| Springer, D | 1 |
| Gucek, M | 1 |
| Pirooznia, M | 1 |
| Cockman, ME | 1 |
| Murphy, E | 1 |
| Kennedy, LM | 1 |
| Boardman, NT | 1 |
| Falck, AT | 1 |
| Lund, T | 1 |
| Chu, X | 1 |
| Martin-Armas, M | 1 |
| Norvik, JV | 1 |
| Jenssen, TG | 1 |
| Ytrehus, K | 1 |
| Shen, S | 1 |
| He, F | 1 |
| Cheng, C | 1 |
| Xu, B | 1 |
| Sheng, J | 1 |
| Mandurino-Mirizzi, A | 1 |
| Crimi, G | 1 |
| Raineri, C | 1 |
| Pica, S | 1 |
| Ruffinazzi, M | 1 |
| Gianni, U | 1 |
| Repetto, A | 1 |
| Ferlini, M | 1 |
| Marinoni, B | 1 |
| Leonardi, S | 1 |
| De Servi, S | 1 |
| Oltrona Visconti, L | 1 |
| De Ferrari, GM | 1 |
| Ferrario, M | 1 |
| Csont, T | 2 |
| Sárközy, M | 2 |
| Szűcs, G | 1 |
| Szűcs, C | 1 |
| Bárkányi, J | 1 |
| Bencsik, P | 2 |
| Gáspár, R | 1 |
| Földesi, I | 1 |
| Csonka, C | 2 |
| Kónya, C | 1 |
| Ferdinandy, P | 2 |
| Okafor, ON | 1 |
| Farrington, K | 1 |
| Gorog, DA | 1 |
| Bruegger, D | 1 |
| Rehm, M | 2 |
| Jacob, M | 2 |
| Chappell, D | 2 |
| Stoeckelhuber, M | 1 |
| Welsch, U | 2 |
| Conzen, P | 2 |
| Becker, BF | 3 |
| Hofmann-Kiefer, K | 1 |
| Strutyns'kyĭ, RB | 1 |
| Kotsiuruba, AV | 1 |
| Neshcheret, OP | 1 |
| Shysh, AM | 1 |
| Rovenets', RA | 1 |
| Moĭbenko, OO | 1 |
| Juhász, L | 1 |
| Kiss, A | 1 |
| Nyeso, E | 1 |
| Kovács, M | 1 |
| Seprényi, G | 1 |
| Kaszaki, J | 1 |
| Végh, A | 1 |
| Kocsis, GF | 1 |
| Pipicz, M | 1 |
| Varga, ZV | 1 |
| Pálóczi, J | 1 |
| Laude, K | 1 |
| Thuillez, C | 1 |
| Richard, V | 1 |
| Tecder-Unal, M | 1 |
| Kanzýk, Y | 1 |
| Getting, SJ | 1 |
| Di Filippo, C | 1 |
| D'Amico, M | 1 |
| Perretti, M | 1 |
| Wang, HC | 1 |
| Zhang, HF | 1 |
| Guo, WY | 1 |
| Su, H | 1 |
| Zhang, KR | 1 |
| Li, QX | 1 |
| Yan, W | 1 |
| Ma, XL | 1 |
| Lopez, BL | 1 |
| Christopher, TA | 1 |
| Gao, F | 1 |
| Kutala, VK | 1 |
| Khan, M | 1 |
| Mandal, R | 1 |
| Potaraju, V | 1 |
| Colantuono, G | 1 |
| Kumbala, D | 1 |
| Kuppusamy, P | 1 |
| Nikolić, A | 2 |
| Mijalković, D | 1 |
| Kastratović, D | 1 |
| Blagojevć, D | 1 |
| Davidović, B | 1 |
| Spasić, M | 1 |
| Giardina, B | 1 |
| Penco, M | 1 |
| Lazzarino, G | 1 |
| Romano, S | 1 |
| Tavazzi, B | 1 |
| Fedele, F | 1 |
| Di Pierro, D | 1 |
| Dagianti, A | 1 |
| Muscari, C | 1 |
| Finelli, C | 1 |
| Stefanelli, C | 1 |
| Flamigni, F | 1 |
| Guarnieri, C | 1 |
| Caldarera, CM | 1 |
| Martín-Jadraque, R | 1 |
| Montero, C | 1 |
| Mostaza, JM | 1 |
| López-Sendón, JL | 1 |
| Argomaniz, L | 1 |
| Llorente, P | 1 |
| Martín-Jadraque, L | 1 |
| Mei, DA | 1 |
| Gross, GJ | 1 |
| Nithipatikom, K | 1 |
| Facino, RM | 1 |
| Carini, M | 1 |
| Aldini, G | 1 |
| Berti, F | 1 |
| Rossoni, G | 1 |
| Bombardelli, E | 1 |
| Morazzoni, P | 1 |
| Tomasetti, M | 1 |
| Alleva, R | 1 |
| Piva, R | 1 |
| Pancrazi, A | 1 |
| Solenghi, MD | 1 |
| Muçaj, A | 1 |
| Littarru, GP | 1 |
| Gille, L | 1 |
| Staniek, K | 1 |
| Nohl, H | 1 |
| Vergely, C | 2 |
| Perrin, C | 1 |
| Laubriet, A | 1 |
| Oudot, A | 1 |
| Zeller, M | 1 |
| Guilland, JC | 1 |
| Rochette, L | 2 |
| Clermont, G | 1 |
| Jazayeri, S | 1 |
| Lahet, JJ | 1 |
| Goudeau, JJ | 1 |
| Lecour, S | 1 |
| David, M | 1 |
| Girard, C | 1 |
| Reinholz, N | 1 |
| Leipert, B | 1 |
| Raschke, P | 1 |
| Gerlach, E | 1 |
| Lacoursiere, L | 1 |
| Kingma, JG | 1 |
| van Jaarsveld, H | 1 |
| Barnard, HC | 1 |
| Barnard, SP | 1 |
| Maartens, JJ | 1 |
| Potgieter, GM | 1 |
1 review available for uric acid and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Allopurinol as a therapeutic option in cardiovascular disease.
Topics: Allopurinol; Animals; Cardiovascular Diseases; Enzyme Inhibitors; Free Radical Scavengers; Humans; H | 2017 |
1 trial available for uric acid and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Elevated serum uric acid affects myocardial reperfusion and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Topics: Aged; Angiography; Female; Humans; Kaplan-Meier Estimate; Linear Models; Magnetic Resonance Imaging; | 2018 |
27 other studies available for uric acid and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury.
Topics: Animals; beta-Alanine; Carnosine; Carrier Proteins; Chromatography, Liquid; Infarction; Inosine; Iro | 2022 |
Human concentrations of uric acid scavenges adaptive and maladaptive reactive oxygen species in isolated rat hearts subjected to ischemic stress.
Topics: Animals; Antioxidants; Humans; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Mito | 2020 |
Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis pathway.
Topics: Animals; Biomarkers; Caspase 3; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Hyperuricemia | 2021 |
Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet.
Topics: Animals; C-Reactive Protein; Cholesterol; Cholesterol, Dietary; Dietary Supplements; Hyperlipidemias | 2013 |
Exogenous nitric oxide requires an endothelial glycocalyx to prevent postischemic coronary vascular leak in guinea pig hearts.
Topics: Adenine Nucleotides; Animals; Coronary Vessels; Endothelium, Vascular; Free Radical Scavengers; Glyc | 2008 |
Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion.
Topics: Animals; Antithrombins; Capillary Permeability; Coronary Vessels; Edema, Cardiac; Endothelial Cells; | 2009 |
[Cardioprotective effects of activation of ATP-sensitive potassium channels in experiments in vivo: influence on blood biochemical parameters following ischemia-reperfusion of the myocardium].
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Dogs; Free Radicals; Hemodynamics | 2009 |
Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion?
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Coronary Vessels | 2011 |
Preconditioning protects the heart in a prolonged uremic condition.
Topics: Angiotensin II; Animals; Biomarkers; Creatinine; Disease Models, Animal; Ischemic Preconditioning, M | 2012 |
Peroxynitrite triggers a delayed resistance of coronary endothelial cells against ischemia-reperfusion injury.
Topics: Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Sca | 2002 |
Peroxynitrite in reperfusion arrhythmias and its whole blood chemiluminescence results.
Topics: Animals; Blood Pressure; Catalase; Drug Administration Schedule; Drug Therapy, Combination; Enzyme I | 2004 |
The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage.
Topics: Acute Disease; alpha-MSH; Animals; Anti-Inflammatory Agents; Blood Pressure; Carrageenan; Chemokine | 2006 |
Hypoxic postconditioning enhances the survival and inhibits apoptosis of cardiomyocytes following reoxygenation: role of peroxynitrite formation.
Topics: Animals; Apoptosis; Cell Survival; Hypoxia; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrog | 2006 |
Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol.
Topics: Animals; Aspirin; Creatine Kinase; Cyclic N-Oxides; L-Lactate Dehydrogenase; Myocardial Ischemia; My | 2006 |
Elevated serum uric acid reduce heart damage in patients undergoing opern-heart surgery.
Topics: Aged; Antioxidants; Carbazoles; Carvedilol; Coronary Artery Bypass; Creatine Kinase; Humans; Male; M | 2006 |
Effectiveness of thrombolysis is associated with a time-dependent increase of malondialdehyde in peripheral blood of patients with acute myocardial infarction.
Topics: Adenosine; Chromatography, High Pressure Liquid; Female; Free Radicals; Humans; Hypoxanthine; Hypoxa | 1993 |
Age-dependent differences of ATP breakdown and ATP-catabolite release in ischemic and reperfused hearts.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aging; Animals; Energy Metabolism; In Vitro Technique | 1993 |
[Urate production in a porcine model of myocardial ischemia-reperfusion].
Topics: Animals; Female; Free Radicals; Hypoxanthine; Hypoxanthines; Myocardial Reperfusion Injury; Myocardi | 1996 |
Simultaneous determination of adenosine, inosine, hypoxanthine, xanthine, and uric acid in microdialysis samples using microbore column high-performance liquid chromatography with a diode array detector.
Topics: Adenosine; Animals; Calibration; Chromatography, High Pressure Liquid; Dogs; Extracellular Space; Hy | 1996 |
Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats.
Topics: Aging; Angiotensin II; Animals; Antioxidants; Ascorbic Acid; Biflavonoids; Blood Glucose; Body Weigh | 1999 |
Evaluation of ischemia-reperfusion damage during coronary angioplasty. Electrocardiographic assessment and biochemical modifications in blood from the coronary sinus.
Topics: Aged; Angioplasty, Balloon, Coronary; Antioxidants; beta Carotene; Female; Humans; Lipid Peroxidatio | 2000 |
Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts.
Topics: Animals; Antimycin A; Antioxidants; Cytochrome b Group; Electron Spin Resonance Spectroscopy; Electr | 2001 |
Postischemic myocardial recovery and oxidative stress status of vitamin C deficient rat hearts.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Electron Spin Resonance Spec | 2001 |
Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass.
Topics: Aged; Cardiopulmonary Bypass; Electron Spin Resonance Spectroscopy; Female; Free Radicals; Humans; M | 2002 |
[Are the radical scavenging properties of ACE inhibitors with sulfhydryl groups in therapeutically effective concentrations of quantitative significance?].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bridged Bicyclo Compounds; Captopril; | 1991 |
Reperfusion-induced arrhythmias are not prevented by uric acid in the isolated rat heart.
Topics: Animals; Arrhythmias, Cardiac; Creatine Kinase; Free Radical Scavengers; In Vitro Techniques; Male; | 1991 |
Purine and oxypurine production in mitochondria of ischemic and reperfused myocardium.
Topics: Adenine Nucleotides; Adenosine; Allopurinol; Animals; Hypoxanthine; Hypoxanthines; Male; Malondialde | 1989 |