uric acid has been researched along with Inflammation in 667 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid (UA) is the final product of purine metabolism in the human body, and impaired purine metabolism can increase the uric acid in serum, finally resulting in hyperuricemia (HUA)." | 9.22 | Excess Uric Acid Induces Gouty Nephropathy Through Crystal Formation: A Review of Recent Insights. ( Dong, B; Geng, Z; Mei, Y; Xu, L, 2022) |
| "Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia." | 9.20 | Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. ( Afsar, B; ALanaspa, M; Bakan, A; Elcioglu, OC; Erek, A; Johnson, RJ; Kanbay, M; Kostek, O; Mutlu, HH; Odabas, AR; Ozkok, A; Semerci, A; Sharma, S; Smits, G; Takir, M; Telci, O, 2015) |
| "The mechanisms of hyperhomocysteinemia (HHcy) and hyperuricemia (HUA) that promote atherosclerosis were seldom explored and always indefinite." | 8.95 | Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis. ( Chen, H; Chen, J; Gu, Y; Liu, N; Yang, K; Zhao, J, 2017) |
| "Uric acid (UA) increase is considered an important risk factor for the development of cardiovascular disease (CVD) favoring oxidative stress and endothelial dysfunction and is also involved in metabolic syndrome (MS) pathophysiology." | 8.88 | The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome. ( Dichi, I; Lozovoy, MA; Simão, AN, 2012) |
| "Uric acid is a terminal metabolite of the degradation of nucleotides, which increases their blood levels in patients with preeclampsia-eclampsia, increasing its synthesis by damage and death of trophoblastic cells in proliferation and decreased urinary excretion due a lower glomerular filtration rate and increased absorption in the proximal tubule." | 8.87 | [Role of uric acid in preeclampsia-eclampsia]. ( Rico-Trejo, EI; Vázquez-Rodríguez, JG, 2011) |
| " The results showed that MFPP could effectively reduce the serum uric acid (SUA) levels compared with the model group rats; kidney histopathology and the levels of inflammatory factors (TNF-α, IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney inflammation." | 8.31 | Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation. ( Hu, Q; Luo, J; Peng, X; Wu, C; Zhang, G, 2023) |
| " Reducing uric acid and inhibiting inflammation are the focused areas of drug research and development on gout." | 8.31 | Rutin ameliorates gout via reducing XOD activity, inhibiting ROS production and NLRP3 inflammasome activation in quail. ( Huang, J; Li, Y; Lin, Z; Wang, Y; Wu, H; Zhang, B, 2023) |
| "We investigated the association of serum uric acid to high-density lipoprotein ratio (UHR) with the presence and severity of metabolic syndrome (MetS) among MASHAD cohort participants." | 8.31 | Serum uric acid to high-density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large-scale study. ( Esmaily, H; Feizi, S; Ghayour-Mobarhan, M; Kolahi Ahari, R; Mansoori, A; Miri, MS; Sahranavard, T, 2023) |
| "Gouty arthritis is generally induced by the accumulation of monosodium urate (MSU) crystals in the joints due to elevated serum uric acid levels, potentially leading to serious pathological disorders such as nephrolithiasis, renal failure, and acute gouty arthritis." | 8.12 | Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt. ( Al Kury, LT; Alattar, A; Alshaman, R; Atzaz, N; Li, S; Riaz, M; Shah, FA, 2022) |
| " These physiological characteristics have promoted the study of poly-gallic acid (PGAL), a poly-oxidized form of gallic acid reported to be effective in in vitro models of inflammation." | 8.12 | Anti-inflammatory and Antioxidant Effect of Poly-gallic Acid (PGAL) in an In Vitro Model of Synovitis Induced by Monosodium Urate Crystals. ( Fernández-Torres, J; Gimeno, M; Luján-Juárez, IA; Martínez-Flores, K; Martínez-López, V; Montaño-Armendariz, N; Sánchez-Sánchez, R; Zamudio-Cuevas, Y, 2022) |
| "Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU) crystals." | 8.12 | Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways. ( Ai, GX; Chen, XY; Cheng, JJ; Li, YC; Ma, XD; Su, ZR; Xie, JH; Xie, QF; Yan, F; Yu, QX, 2022) |
| "To assess the effects of anethole on monosodium urate (MSU)-induced inflammatory response, investigate its role in acute gouty arthritis (AGA), and verify its molecular mechanism." | 8.12 | Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway. ( Cao, Y; Liu, Z; Tang, F; Yao, X; Zhang, X; Zhong, Q, 2022) |
| "Despite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation." | 8.02 | Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status. ( Ahn, YM; Lee, H; Rhee, SJ, 2021) |
| " This study investigated the effects of two neutral CB1 receptor antagonists, AM6545 and AM4113, on nephropathy associated with metabolic syndrome (MetS)." | 8.02 | Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome. ( Aldawsari, HM; Binmahfouz, L; Eid, BG; El-Aziz, GA; El-Bassossy, HM; Hanafy, A; Hasan, A; Makriyannis, A; Neamatallah, T; Vemuri, K, 2021) |
| "The current work explored the influences of nifuroxazide, an in vivo inhibitor of signal transducer and activator of transcription-3 (STAT-3) activation, on tubulointerstitial fibrosis in rats with obstructive nephropathy using unilateral ureteral obstruction (UUO) model." | 8.02 | Nifuroxazide suppresses UUO-induced renal fibrosis in rats via inhibiting STAT-3/NF-κB signaling, oxidative stress and inflammation. ( Hassan, NME; Said, E; Shehatou, GSG, 2021) |
| "Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues." | 8.02 | Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage. ( Cho, YY; Choi, N; Jang, JH; Kang, HC; Lee, HS; Lee, JY; Yang, G, 2021) |
| "Hyperuricemia (HUA) is induced by abnormal purine metabolism and elevated serum uric acid (UA) concentrations, and it is often accompanied by inflammatory responses and intestinal disorders." | 8.02 | Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis. ( Hu, N; Lin, Y; Wang, J; Wang, S; Wang, X; Zhang, B; Zhao, X; Zhou, X, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 8.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)." | 8.02 | Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021) |
| " The effects of phloretin on renal function, fibrosis, oxidative stress, inflammation, and UA metabolism in HUA mice were evaluated." | 7.96 | Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption. ( Chen, Y; Cheng, J; Cui, D; Li, L; Liu, J; Liu, S; Lu, Y; Mao, R; Tang, M; Wang, C; Yuan, Y; Zhao, M, 2020) |
| "Eucalyptol alleviates MSU-induced pain and inflammation via mechanisms possibly involving anti-oxidative effect." | 7.96 | Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. ( Li, X; Li, Y; Liu, B; Tai, Y; Wang, C; Wang, P; Yin, C; Zheng, X, 2020) |
| "The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo." | 7.96 | Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. ( Hosoyamada, M; Kimura, Y; Kono, H; Onda, A; Tsukui, D; Yanagida, T, 2020) |
| " Here, we reported that dehydrocostus lactone (DCL), a main component of Saussurea lappa from the traditional Chinese medicine, inhibited NLRP3 inflammasome-mediated caspase-1 activation and subsequent interleukin (IL)-1β production in primary mouse macrophages and human peripheral blood mononuclear cells and exerted an inhibitory effect on NLRP3-driven inflammation." | 7.96 | Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo. ( Ai, Y; Bai, Z; Chen, Y; Hou, X; Li, R; Shi, W; Sun, H; Wang, C; Wang, JB; Wang, Z; Xiao, X; Xu, G; Zhan, X, 2020) |
| " Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammation." | 7.96 | Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages. ( Jiang, M; Jiao, JY; Li, Y; Lian, LH; Lin, YC; Liu, J; Nan, JX; Piao, MH; Qiao, CY; Shang, Y; Sun, RH; Wu, YL; Ye, H; Zhan, ZY; Zhang, ZH, 2020) |
| "BACKGROUND This study was to investigate the correlation between osteoporosis and serum uric acid in ankylosing spondylitis (AS) patients, and to further identify potential factors that might be associated with osteoporosis in AS patients." | 7.91 | Serum Uric Acid Shows Inverted "U" Type Correlation with Osteoporosis in Chinese Ankylosing Spondylitis Patients: A Retrospective Study. ( Chen, YT; Chen, Z; Lin, C; Liu, X; Song, P; Wu, Y; Xu, Q; Yang, P; Yang, Y, 2019) |
| "Uric acid is persistently high after HS and leads to the activation of caspases-8 and organ inflammation; these can be prevented by an intervention to degrade UA." | 7.91 | Caspase-(8/3) activation and organ inflammation in a rat model of resuscitated hemorrhagic shock: A role for uric acid. ( Baril, F; Bouchard, C; Brochiero, E; Cardinal, AM; Charbonney, E; Dunberry-Poissant, S; Gilbert, K; Khazoom, F; Rousseau, G; Vega, MA, 2019) |
| "These results indicated that curcumin could effectively ameliorate MSU crystal-induced gouty arthritis through NLRP3 inflammasome mediation via inhibiting NF-κB signaling both in vitro and in vivo, suggesting a promising active ingredient for the prevention and treatment of gouty arthritis." | 7.91 | Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling. ( He, X; Li, X; Sun, DY; Xiao, DM; Xu, DQ; Zhang, T, 2019) |
| "Gouty arthritis is an inflammatory disease that is triggered by abnormal uric acid metabolism, which is usually attributed to obesity, a risk factor of hyperuricemia and gout attack." | 7.91 | Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout. ( Fu, S; Liang, M; Lv, L; Wan, W; Xuan, D; Xue, Y; Yang, J; Yu, Y; Zhu, X; Zou, H, 2019) |
| " Following a low-calorie diet with a lower glycemic index is proposed to silence inflammation by increasing the concentration of uric acid." | 7.91 | A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS). ( Drozd, R; Szczuko, M; Zapalowska-Chwyć, M, 2019) |
| " We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation." | 7.91 | Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis. ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Park, YB; Yang, G, 2019) |
| "Conflicting results suggest a link between serum uric acid (SUA), inflammation and glucose/insulin homeostasis; however, the role of adiposity in this relationship is not clear." | 7.88 | The link between insulin resistance parameters and serum uric acid is mediated by adiposity. ( Banach, M; Katsiki, N; Mazidi, M; Mikhailidis, DP, 2018) |
| " Both Diosmin and Crocin improved insulin resistance, decreased blood pressure, uric acid, lipoproteins and blocked diabetic nephropathy as indicated by reduction of albumin excretion rate and albumin/creatinine ratio." | 7.88 | Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation. ( El Fayoumi, HM; El-Fawal, R; Mahmoud, MF, 2018) |
| "Aim To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevated CRP (predictor of worse cardiovascular outcomes)." | 7.88 | A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction. ( Brizić, I; Čaušević, A; Jelić Knezović, N; Marković Boras, M; Mikulić, I; Vasilj, M, 2018) |
| " We injected uric acid intraperitoneally, 125mg/kg/day for 7 days (UA7) and 14 days (UA14), to induce hyperuricemia and then gave allopurinol 50mg/kg/day for 7 days to lower serum uric acid levels (UA7AL7 and UA14AL7)." | 7.88 | Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model. ( Arfian, N; Haryono, A; Nugrahaningsih, DAA; Romi, MM; Sari, DCR, 2018) |
| "Procyanidins significantly attenuated gout pain and suppressed ankle swelling." | 7.85 | Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. ( Fan, YX; Gui, X; Han, Y; Hu, L; Jiang, CY; Liu, BQ; Liu, HJ; Liu, WT; Pan, XX; Tang, YL, 2017) |
| "XO inhibition significantly attenuated WD-induced increases in plasma uric acid, vascular XO activity and oxidative stress, in concert with reductions in proteinuria." | 7.85 | Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice. ( Aroor, AR; Brady, B; Chen, D; Demarco, VG; Habibi, J; Jia, G; Manrique, C; Martinez-Lemus, LA; Meininger, GA; Nistala, R; Ramirez-Perez, FI; Sowers, JR; Sun, Z; Whaley-Connell, AT, 2017) |
| "Uric acid (UA) plays important roles in inducing renal inflammation, intra-renal vasoconstriction and renal damage." | 7.85 | Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation. ( Arfian, N; Romi, MM; Sari, DCR; Setyaningsih, WAW; Tranggono, U, 2017) |
| "Patients with psoriasis have increased systemic inflammation and serum uric acid (SUA) levels compared with the general population." | 7.85 | Impact of Elevated Serum Uric Acid Levels on Systemic Inflammation in Patients With Psoriasis. ( Dikicier, BS; Erdem, T; Solak, B, 2017) |
| "Using mass spectrometry, oxidation products of glutathione and uric acid were measured in matched samples of bronchoalveolar lavage (BAL), serum and urine from 36 infants and children with CF, and related to markers of neutrophilic inflammation and infection in BAL." | 7.85 | Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. ( Dickerhof, N; Fantino, E; Kettle, AJ; Khalilova, I; Sly, PD; Turner, R, 2017) |
| "Uric acid is a risk factor for coronary artery disease in postmenopausal women, but the association with inflammation and coronary endothelial dysfunction (CED) is not well defined." | 7.85 | Uric Acid Is Associated With Inflammation, Coronary Microvascular Dysfunction, and Adverse Outcomes in Postmenopausal Women. ( Gulati, R; Herrmann, J; Lerman, A; Lerman, LO; Matteson, EL; Prasad, M; Rihal, CS, 2017) |
| "Elevated serum uric acid (SUA) level is strongly associated with prevalence of metabolic syndrome (MS), elevated parathyroid hormone (PTH) levels, and 25-hydroxyvitamin D [25(OH)D] insufficiency in adults." | 7.83 | Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. ( Alemzadeh, R; Kichler, J, 2016) |
| "The aim of this study was to investigate the anti-inflammatory effect of ferulic acid, a dietary phenol, on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis." | 7.83 | Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats. ( Dey, C; Doss, HM; Rasool, MK; Sudandiradoss, C, 2016) |
| " The effects and possible molecular mechanisms of astilbin on potassium oxonate-induced hyperuricemia mice were investigated in this study." | 7.83 | Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice. ( Chen, J; Wang, M; Zhang, N; Zhao, J, 2016) |
| "The association between serum uric acid concentrations and inflammation in patients with rheumatoid arthritis (RA) has been still controversial." | 7.81 | Association between serum uric acid and inflammation in rheumatoid arthritis: perspective on lowering serum uric acid of leflunomide. ( Choe, JY; Kim, SK, 2015) |
| "To assess serum levels and correlation between uric acid (UA) and C-reactive protein (CRP) in acute coronary syndrome (ACS) and apparently healthy individuals." | 7.81 | Positive correlation between uric acid and C-reactive protein serum level in healthy individuals and patients with acute coronary syndromes. ( Hasić, S; Kiseljaković, E; Kulić, M; Resić, H; Spahić, E, 2015) |
| "To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation." | 7.81 | Uric acid correlates to oxidation and inflammation in opposite directions in women. ( Cai, Q; Chen, H; Fazio, S; Gao, YT; Linton, MF; Milne, G; Purdue, M; Rothman, N; Shu, XO; Wu, SH; Xiang, YB; Yang, G; Zhang, X; Zheng, W, 2015) |
| "The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation." | 7.80 | The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. ( Arts, IC; Boonen, A; Dagnelie, PC; Ferreira, I; Feskens, EJ; Schalkwijk, CG; Stehouwer, CD; van der Kallen, CJ; van der Linden, S; van Greevenbroek, MM; Wijnands, JM, 2014) |
| "Acute gout is associated with a decrease in serum uric acid (SUA) that is considered to be in response to acute inflammation but it may be a feature of gout itself." | 7.79 | The effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on serum uric acid in patients without gout: a prospective study. ( Ashby, HL; Chugh, S; Deshpande, S; Ford, C; Gama, R; Razavi, C; Thomas, OL; Waldron, JL, 2013) |
| "Uric acid (UA) is independently associated with the emergence of hypertension." | 7.79 | Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. ( Aydoğdu, S; Işleyen, A; Johnson, RJ; Kanbay, M; McFann, K; Ozcan, F; Sen, N; Sökmen, E; Taşoğlu, I; Tok, D; Turak, O, 2013) |
| " In the present study, we found that treatment with lemnalol (intramuscular [im]), but not colchicine (oral [po]), significantly attenuated MUS-induced mechanical allodynia, paw edema and knee swelling." | 7.79 | Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression. ( Duh, CY; Huang, SY; Jean, YH; Lee, HP; Lin, YY; Wang, HM; Wen, ZH; Wu, SF, 2013) |
| "Elevated serum uric acid has been associated with a variety of cardiovascular disease and with inflammation, but these have been little explored in chronic kidney disease (CKD)." | 7.79 | Is there association between uric acid and inflammation in hemodialysis patients? ( Carraro-Eduardo, JC; da Nóbrega, AC; Lobo, JC; Mafra, D; Stockler-Pinto, MB, 2013) |
| "To explore the correlations between serum uric acid (UA) levels and the clinical and cerebrospinal fluid (CSF) parameters of multiple sclerosis (MS)." | 7.78 | Correlations between serum uric acid level and disease activity, intrathecal inflammation reactivity in patients with multiple sclerosis. ( Chen, XW; Cui, LY; Liu, CY; Peng, B; Wang, JM; Xu, Y; Zhong, LZ, 2012) |
| "These results indicated that quercetin exerted a strong anti-inflammatory effect that may be useful for the treatment of acute gouty arthritis." | 7.78 | Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. ( Chen, J; Huang, J; Li, S; Sun, W; Tao, Y; Wang, S; Zhu, M, 2012) |
| "The data regarding the role of serum uric acid (SUA) along with subclinical inflammation in the context of hypertensive vascular damage are rather scarce and controversial." | 7.77 | The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. ( Dimitriadis, K; Katsi, V; Kyvelou, S; Lalos, S; Mihas, C; Poulakis, M; Sideris, S; Skiadas, I; Stefanadi, E; Stefanadis, C; Syrseloudis, D; Tsioufis, C, 2011) |
| "Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population." | 7.77 | Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients. ( Chen, Y; Ding, X; Fang, Y; Liu, Z; Shen, B; Teng, J; Wang, Y; Xu, S; Zhong, Y; Zou, J, 2011) |
| "To examine the association between renal function, serum uric acid and markers of both pro-inflammatory and prothrombotic state in patients with diabetes mellitus (DM), metabolic syndrome and coronary artery disease." | 7.77 | Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease. ( Buraczyńska, MJ; Kondracki, B; Rychta, E; Waciński, P; Wysokiński, A; Zapolski, T, 2011) |
| "This study aimed to evaluate the association of serum inflammatory markers (C-reactive protein (CRP) and uric acid (UA)), magnesium and other CVD risk factors with insulin resistance (IR) among Chinese postmenopausal women with prediabetes." | 7.77 | The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes. ( Ho, SC; Liu, ZM, 2011) |
| "Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses." | 7.77 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis. ( Chen, DP; Lam, CW; Li, EK; Tam, LS; Wong, CK, 2011) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 7.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| "The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine and metamizol combination on different levels of nociception (levels I, II, and III) using the "Pain-induced functional impairment model in the rat"." | 7.74 | The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain. ( Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Godínez-Chaparro, B; Guevara-López, U; Huerta-Cruz, JC; López-Muñoz, FJ, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 7.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| "We examined the associations of serum uric acid (UA) with indices of coronary heart disease (CHD) risk, including the 10-year probability of CHD (10y-CHDr), metabolic syndrome (MS), inflammation (C-reactive protein [CRP] and fibrinogen), and the presence and quantity of coronary artery calcium (CAC)." | 7.74 | Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis. ( Bielak, LF; Coutinho, Tde A; Kullo, IJ; Peyser, PA; Sheedy, PF; Turner, ST, 2007) |
| "The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation." | 7.74 | Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. ( Baumert, J; Döring, A; Koenig, W; Meisinger, C, 2008) |
| "Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues." | 7.73 | Gout-associated uric acid crystals activate the NALP3 inflammasome. ( Martinon, F; Mayor, A; Pétrilli, V; Tardivel, A; Tschopp, J, 2006) |
| "The aim of this study was to test the hypothesis that pulmonary inflammation and emphysema induced by cadmium (Cd) inhalation are associated with pulmonary oxidative stress." | 7.73 | Airway inflammation in cadmium-exposed rats is associated with pulmonary oxidative stress and emphysema. ( Fievez, L; Gustin, P; Kirschvink, N; Marlin, D; Martin, N; Smith, N, 2006) |
| "Abdominal obesity is the main determinant of uric acid variance." | 7.73 | Serum uric acid is a determinant of metabolic syndrome in a population-based study. ( Albayrak, S; Hergenç, G; Karabulut, A; Keleş, I; Onat, A; Sari, I; Uyarel, H; Yazici, M, 2006) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 7.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "A subcutaneous air pouch formed in Sprague-Dawley rats was used to study the effect of diets enriched in gamma-linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals." | 7.67 | Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. ( Baker, DG; Karmali, RA; Laposata, M; Mandell, BF; Schumacher, HR; Tate, GA; Zurier, RB, 1988) |
| "Hyperuricemia is associated with the activation of the Nod-like receptor protein 3 inflammasome." | 7.30 | C-reactive Protein Levels and Cardiovascular Outcomes After Febuxostat Treatment in Patients with Asymptomatic Hyperuricemia: Post-hoc Analysis of a Randomized Controlled Study. ( Hayashi, T; Hiramitsu, S; Hisatome, I; Jinnouchi, H; Kakuda, H; Kawai, N; Kimura, K; Kojima, S; Matsui, K; Mori, H; Ogawa, H; Ohya, Y; Saito, Y; Sugawara, M; Tokutake, E; Tsujita, K; Uchiyama, K; Wakasa, Y; Waki, M; Yokota, N, 2023) |
| "Uric acid is an important contributor to inflammatory cytokine secretion, dendritic cell and T cell responses induced by Plasmodium, suggesting uric acid as a novel molecular target for anti-inflammatory therapies in malaria." | 6.50 | A surprising role for uric acid: the inflammatory malaria response. ( Gallego-Delgado, J; Orengo, JM; Rodriguez, A; Ty, M; van de Hoef, D, 2014) |
| "Uric acid is a waste product of purine catabolism." | 6.49 | Uric acid as a danger signal in gout and its comorbidities. ( Kataoka, H; Lai, JJ; Rock, KL, 2013) |
| "Uric acid has been identified as an endogenous adjuvant that drives immune responses in the absence of microbial stimulation." | 6.47 | The role of uric acid as an endogenous danger signal in immunity and inflammation. ( Ghaemi-Oskouie, F; Shi, Y, 2011) |
| "Melatonin (MLT) is a powerful endogenous anti-inflammatory agent and effective in reducing cellular damage." | 5.72 | Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis. ( Altinoz, E; Ballur, AFH; Bicer, Y; Demir, M; Elbe, H; Karayakali, M; Onal, MO; Yigitturk, G, 2022) |
| "Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues." | 5.72 | Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy. ( Jiang, YJ; Lian, LH; Nan, JX; Piao, MH; Wang, H; Wu, YL, 2022) |
| "Gout is a painful form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints." | 5.72 | The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model. ( Aganetti, M; Amaral, FA; Braga, AD; de Faria, AMC; de Oliveira, VLS; Galvão, I; Georgel, P; Martins, VD; Mastrippolito, D; Mendes, V; Muller, S; Rocha, V; Talamini, L; Verdot, C; Vieira, AT, 2022) |
| "Hyperuricemia is the primary cause of gouty arthritis and other metabolic disorders." | 5.62 | Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats. ( Kim, DS; Sung, YY, 2021) |
| "Inflammation is an important pathological feature of hyperuricemia, which in turn aggravates hyperuricemia." | 5.62 | Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice. ( Chen, Y; Liu, T; Yang, Z; Yuan, F; Zhang, L; Zhang, S; Zhou, X; Zhuang, J, 2021) |
| "Allopurinol treatment significantly reduced hepatic steatosis, epididymal fat, serum UA, HOMA-IR, hepatic enzyme levels, and cholesterol in the OLETF-HFrD-Allo group." | 5.62 | Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. ( Ahn, KJ; Cho, IJ; Chung, HY; Hwang, YC; Jeong, IK; Jeong, SW; Lee, SH; Lim, SJ; Moon, JY; Oh, DH; Yoo, J, 2021) |
| "Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases." | 5.51 | mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy? ( Broen, JCA; Jansen, M; Merriman, T; Ottria, A; Phipps-Green, A; Radstake, TRDJ; Schuiveling, M; van der Linden, M; van Lochem, E; Vazirpanah, N; Wichers, CGK; Zimmermann, M, 2019) |
| "Nicotine is an important factor in the pathogenesis of renal injury in smokers." | 5.48 | Renoprotective effect of Spirulina platensis extract against nicotine-induced oxidative stress-mediated inflammation in rats. ( Emam, MA; Zahran, WE, 2018) |
| "Hyperuricemia is an important risk factor for cardiovascular and renal diseases." | 5.46 | Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. ( Chen, Y; Cheng, J; Liu, J; Liu, S; Lu, Y; Yuan, Y; Zhao, M; Zhou, Y, 2017) |
| "Because inflammation has an important pathogenetic role in metabolic and cardiovascular disease, our study may help understanding the mechanism by which hyperuricemia may contribute to organ damage." | 5.46 | Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells. ( Andreozzi, F; Di Fatta, C; Fuoco, A; Mancuso, E; Mannino, GC; Marini, MA; Perticone, F; Sesti, G; Spiga, R, 2017) |
| "The bilirubin and UA levels were lower in CIS and RRMS patients than in control group, whether male or female (p < 0." | 5.39 | Association of serum bilirubin and uric acid levels changes during neuroinflammation in patients with initial and relapsed demyelination attacks. ( Dunjic, O; Ljubisavljevic, S; Milojkovic, M; Pavlovic, D; Stojanov, D; Stojanovic, I; Vojinovic, S, 2013) |
| "In conclusion, weight loss is effective in treating obese children with SDB." | 5.38 | Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid. ( Aerts, P; De Backer, WA; Debode, P; Desager, KN; Franckx, H; Ramet, J; Van Gaal, LF; Van Hoorenbeeck, K; Verhulst, SL; Wouters, K, 2012) |
| "Hyperuricemia is common after kidney transplantation." | 5.35 | Association of uric acid with inflammation, progressive renal allograft dysfunction and post-transplant cardiovascular risk. ( Bandukwala, F; Huang, M; Nash, MM; Prasad, GV; Zaltzman, JS, 2009) |
| "Gout is an acute rheumatic disorder that occurs in connection with the deposition of monosodium urate (MSU) crystals in the joints." | 5.30 | Altered arachidonic acid metabolism in urate crystal induced inflammation. ( Duffin, KL; Gregory, SA; Isakson, PC; Margalit, A; Shaffer, AF, 1997) |
| "Uric acid (UA) is the final product of purine metabolism in the human body, and impaired purine metabolism can increase the uric acid in serum, finally resulting in hyperuricemia (HUA)." | 5.22 | Excess Uric Acid Induces Gouty Nephropathy Through Crystal Formation: A Review of Recent Insights. ( Dong, B; Geng, Z; Mei, Y; Xu, L, 2022) |
| "Gout is well known as an inflammatory rheumatic disease presenting with arthritis and abnormal metabolism of uric acid." | 5.22 | Gout and Diet: A Comprehensive Review of Mechanisms and Management. ( Chen, S; Xu, H; Xu, Y; Yuan, M; Zhang, Y, 2022) |
| "Amelioration of both oxidative and inflammation status after cholesterol lowering treatment in CKD might be mediated by restoration of antioxidant taurine concentrations during therapy (from 51." | 5.20 | Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement. ( Carru, C; Mangoni, AA; Sanna, M; Satta, AE; Sotgia, S; Zinellu, A, 2015) |
| "Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia." | 5.20 | Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. ( Afsar, B; ALanaspa, M; Bakan, A; Elcioglu, OC; Erek, A; Johnson, RJ; Kanbay, M; Kostek, O; Mutlu, HH; Odabas, AR; Ozkok, A; Semerci, A; Sharma, S; Smits, G; Takir, M; Telci, O, 2015) |
| " Blood samples were analyzed for malondialdehyde (MDA), as a biomarker of lipid peroxidation; uric acid (UA) as an intrinsic antioxidant; creatinin kinase (CK) activity, as a biomarker of muscle damage as well as total and differential leucocytes, as biomarkers of inflammation." | 5.13 | Influence of aerobic exercise at high and moderate intensities on lipid peroxidation in untrained men. ( Nakhostin-Roohi, B; Seifi-Skishahr, F; Siahkohian, M, 2008) |
| " High-serum uric acid can trigger renal inflammation." | 5.12 | The roles of NLRP3 inflammasome-mediated signaling pathways in hyperuricemic nephropathy. ( Fu, P; Ma, L; Wen, L; Yang, H, 2021) |
| " Fructose overconsumption may result in insulin resistance, oxidative stress, inflammation, elevated uric acid levels, increased blood pressure, and increased triglyceride concentrations in both the blood and liver." | 5.12 | Fructose and the Liver. ( López-Sánchez, P; Muriel, P; Ramos-Tovar, E, 2021) |
| " The indirect effects involve a reduction in insulin levels and resistance, uric acid concentration, body weight, and blood pressure." | 4.98 | The Anticipated Renoprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors. ( Ito, M; Tanaka, T, 2018) |
| "The mechanisms of hyperhomocysteinemia (HHcy) and hyperuricemia (HUA) that promote atherosclerosis were seldom explored and always indefinite." | 4.95 | Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis. ( Chen, H; Chen, J; Gu, Y; Liu, N; Yang, K; Zhao, J, 2017) |
| "It appears that soluble uric acid has a much larger role to play than just being a risk factor for gout." | 4.95 | Factors modulating the inflammatory response in acute gouty arthritis. ( Cleophas, MC; Crişan, TO; Joosten, LA, 2017) |
| " In addition, various other abnormalities such as inflammation, oxidative stress, and elevated levels of uric acid are also part of this syndrome." | 4.95 | Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation. ( Akolkar, G; Ayyappan, P; Bagchi, A; Belló-Klein, A; Bernardes, N; da Silva Dias, D; De Angelis, K; Singal, PK, 2017) |
| "The hypothesis that dietary (poly)phenols promote well-being by improving chronic disease-risk biomarkers, such as endothelial dysfunction, chronic inflammation and plasma uric acid, is the subject of intense current research, involving human interventions studies, animal models and in vitro mechanistic work." | 4.93 | At the interface of antioxidant signalling and cellular function: Key polyphenol effects. ( Kerimi, A; Williamson, G, 2016) |
| " In gout, inflammation arises from precipitation of uric acid in the form of needle-shaped monosodium urate crystals." | 4.91 | How neutrophil extracellular traps orchestrate the local immune response in gout. ( Hahn, J; Herrmann, M; Hoffmann, MH; Kienhöfer, D; Manger, B; Maueröder, C; Schauer, C; Schett, G, 2015) |
| " Twenty-five out of 41 trials, involving 23 different herbal prescriptions, found statistical significance in lowering serum uric acid level, and the overall effect from Chinese herbal medicine in inflammation relief is better than conventional therapies in 19 trials with 17 different prescriptions." | 4.89 | Chinese herbal medicine for gout: a systematic review of randomized clinical trials. ( Han, M; Li, XX; Liu, JP; Wang, YY, 2013) |
| "Traditionally, serum uric acid (SUA) has been implicated in acute gouty arthritis or chronic gouty arthropathy." | 4.89 | Hyperuricaemia: more than just a cause of gout? ( Athyros, VG; Karagiannis, A; Katsiki, N; Mikhailidis, DP, 2013) |
| "Uric acid (UA) increase is considered an important risk factor for the development of cardiovascular disease (CVD) favoring oxidative stress and endothelial dysfunction and is also involved in metabolic syndrome (MS) pathophysiology." | 4.88 | The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome. ( Dichi, I; Lozovoy, MA; Simão, AN, 2012) |
| "Uric acid is a terminal metabolite of the degradation of nucleotides, which increases their blood levels in patients with preeclampsia-eclampsia, increasing its synthesis by damage and death of trophoblastic cells in proliferation and decreased urinary excretion due a lower glomerular filtration rate and increased absorption in the proximal tubule." | 4.87 | [Role of uric acid in preeclampsia-eclampsia]. ( Rico-Trejo, EI; Vázquez-Rodríguez, JG, 2011) |
| "Gout is a common metabolic disorder characterized by elevated uric acid leading to the formation and accumulation of uric acid crystals in synovial fluids." | 4.86 | Update on biology: uric acid and the activation of immune and inflammatory cells. ( Martinon, F, 2010) |
| " Specifically, we review newly discovered mechanisms of uric acid-induced inflammation, uric acid's putative role as a "danger signal" in innate immunity, the possible link between hyperuricemia and cardiovascular disease, and evolutionary evidence suggesting that hyperuricemia conferred a survival advantage in primates (when the gene for uricase was lost) several million years ago." | 4.84 | Update on gout: pathophysiology and potential treatments. ( Abeles, AM; Cronstein, BN; Park, JY; Pillinger, MH, 2007) |
| "Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated oxidative stress." | 4.31 | Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency. ( Eräranta, A; Honkanen, T; Kurra, V; Lakkisto, P; Mustonen, J; Myllymäki, J; Paavonen, T; Pörsti, I; Riutta, A; Tikkanen, I, 2023) |
| " Hyperuricemia mice are induced via daily oral gavage of potassium oxonate and hypoxanthine." | 4.31 | Anti-Hyperuricemic, Nephroprotective, and Gut Microbiota Regulative Effects of Separated Hydrolysate of α-Lactalbumin on Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice. ( Du, L; Shen, Y; Su, E; Wei, D; Xie, D; Xie, J, 2023) |
| "Our findings linked normouricemic erosive gout to attenuated lubricin, with impaired control of cathepsin G activity, compounded by deleterious NLRP3 variants." | 4.31 | Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia. ( Cadzow, M; Campeau, A; Chhana, A; Dalbeth, N; Dambruoso, TJ; Elsaid, K; Elsayed, S; Ghassemian, M; Gonzalez, DJ; Höglund, J; Jay, GD; Karlsson, NG; Karsh, J; Liu-Bryan, R; Maltez, N; Merriman, TR; Miner, M; Phipps-Green, A; Qadri, M; Rossitto, LA; Schmidt, TA; Terkeltaub, R, 2023) |
| " The results showed that MFPP could effectively reduce the serum uric acid (SUA) levels compared with the model group rats; kidney histopathology and the levels of inflammatory factors (TNF-α, IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney inflammation." | 4.31 | Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation. ( Hu, Q; Luo, J; Peng, X; Wu, C; Zhang, G, 2023) |
| " Reducing uric acid and inhibiting inflammation are the focused areas of drug research and development on gout." | 4.31 | Rutin ameliorates gout via reducing XOD activity, inhibiting ROS production and NLRP3 inflammasome activation in quail. ( Huang, J; Li, Y; Lin, Z; Wang, Y; Wu, H; Zhang, B, 2023) |
| "Uric acid (UA) accumulation triggers endothelial dysfunction, oxidative stress, and inflammation." | 4.31 | HDAC Inhibitors Alleviate Uric Acid-Induced Vascular Endothelial Cell Injury by Way of the HDAC6/FGF21/PI3K/AKT Pathway. ( Du, Y; Guan, C; Huang, Z; Li, P; Wang, K; Zhang, Y; Zhou, M, 2023) |
| " Histopathological examination of the heart, and biochemical examinations for heart function (creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST)), inflammation (tumor necrosis factor-alpha (TNF-α) and interleukin 10 (IL-10)), oxidative stress (malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase, nitric oxide (NO), and uric acid), kidney function (urea and creatinine), and minerals (calcium, phosphorus, sodium, and potassium) were carried out." | 4.31 | Glycine protects against doxorubicin-induced heart toxicity in mice. ( El-Ablack, FZ; Saad, EA; Shosha, MI, 2023) |
| " However, its mechanism of action on lowering uric acid (UA) and inhibiting inflammation still deserves further investigation." | 4.31 | Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice. ( Dai, X; Gao, S; Liu, T; Liu, Y; Orekhov, AN; Shi, H; Sukhorukov, V; Wang, L; Wang, S; Xu, T; Yin, J; Zhang, D; Zhang, Y; Zhao, D, 2023) |
| "Study aims to assess uric acid levels with severity of CLD, which is in turn a marker of inflammation and to establish cut off levels with severity of CLD in the current study." | 4.31 | Predictive Ability of Serum Uric Acid Levels in Assessing the Severity of Chronic Liver Disease. ( N, AY, 2023) |
| "Hyperuricemic nephropathy may be induced by the elevation and accumulation of uric acid in kidney after hyperuricemia, which leads to kidney residential cells apoptosis and inflammation." | 4.31 | Renal herb formula protects against hyperuricemic nephropathy by inhibiting apoptosis and inflammation. ( Feng, Y; Li, S; Tang, GY; Wang, N; Xu, L; Xu, XY; Xu, Y; Zhang, C, 2023) |
| "Monosodium uric acid (MSU) crystal, the etiological agent of gout, has been shown to trigger innate immune responses via multiple pathways." | 4.31 | Clec12a inhibits MSU-induced immune activation through lipid raft expulsion. ( Li, S; Shi, Y; Song, D; Wang, W; Xia, T; Xu, Y; Yue, T, 2023) |
| "We investigated the association of serum uric acid to high-density lipoprotein ratio (UHR) with the presence and severity of metabolic syndrome (MetS) among MASHAD cohort participants." | 4.31 | Serum uric acid to high-density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large-scale study. ( Esmaily, H; Feizi, S; Ghayour-Mobarhan, M; Kolahi Ahari, R; Mansoori, A; Miri, MS; Sahranavard, T, 2023) |
| " Hence, it has been of particular interest to dissect the exact role of alteration in uric acid (UA) levels in the context of inflammation." | 4.12 | Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells. ( Ebrahimi, R; Emamgholipour, S; Pasalar, P; Shabani, M; Shokri, H, 2022) |
| "Purine not only acts as a metabolic substrate of XOR for UA production, but it induces inflammation through IFN-γ secretion that stimulates UA production through elevation of XOR expression." | 4.12 | Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. ( Huang, D; Li, X; Liang, B; Lin, Z; Song, X; Su, T; Wang, H; Wang, J; Xie, L, 2022) |
| " We hypothesized that asymptomatic HU would attenuate AKD because soluble, in contrast to crystalline, uric acid (sUA) can attenuate sterile inflammation." | 4.12 | Asymptomatic Hyperuricemia Promotes Recovery from Ischemic Organ Injury by Modulating the Phenotype of Macrophages. ( Anders, HJ; Carangelo, G; De Chiara, L; Gnemmi, V; Li, C; Li, Q; Ma, Q; Molina-Van den Bosch, M; Romagnani, P; Steiger, S, 2022) |
| "Gouty arthritis is generally induced by the accumulation of monosodium urate (MSU) crystals in the joints due to elevated serum uric acid levels, potentially leading to serious pathological disorders such as nephrolithiasis, renal failure, and acute gouty arthritis." | 4.12 | Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt. ( Al Kury, LT; Alattar, A; Alshaman, R; Atzaz, N; Li, S; Riaz, M; Shah, FA, 2022) |
| " These physiological characteristics have promoted the study of poly-gallic acid (PGAL), a poly-oxidized form of gallic acid reported to be effective in in vitro models of inflammation." | 4.12 | Anti-inflammatory and Antioxidant Effect of Poly-gallic Acid (PGAL) in an In Vitro Model of Synovitis Induced by Monosodium Urate Crystals. ( Fernández-Torres, J; Gimeno, M; Luján-Juárez, IA; Martínez-Flores, K; Martínez-López, V; Montaño-Armendariz, N; Sánchez-Sánchez, R; Zamudio-Cuevas, Y, 2022) |
| " the xanthine oxidase inhibitors allopurinol and febuxostat), traditional Chinese medicine has fewer side effects in the treatment of gout and can safely control serum uric acid and the level of inflammation." | 4.12 | Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity. ( Liu, ZB; Liu, ZQ; Sun, X; Wu, CJ; Zhang, LL; Zhang, T, 2022) |
| "Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU) crystals." | 4.12 | Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways. ( Ai, GX; Chen, XY; Cheng, JJ; Li, YC; Ma, XD; Su, ZR; Xie, JH; Xie, QF; Yan, F; Yu, QX, 2022) |
| "Sera of gout patients meeting the 2015 ACR/EULAR gout classification criteria (n = 20) and with hyperuricemia were studied at time zero and weeks 12 and 24 of febuxostat or allopurinol dose titration ULT." | 4.12 | Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes. ( Bittleman, D; Coras, R; Dadpey, B; Guma, M; Hamilton, B; Lauro, K; Liu-Bryan, R; Mikuls, TR; Quehenberger, O; Reilly, SM; Terkeltaub, R; Thorisdottir, H, 2022) |
| "Abnormal uric acid level result in the development of hyperuricemia and hallmark of various diseases, including renal injury, gout, cardiovascular disorders, and non-alcoholic fatty liver." | 4.12 | Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice. ( Alharthi, F; Althobaiti, F; Chen, X; Mehmood, A; Murtaza, MA; Nadeem, M; Ranjha, MMAN; Shah, AA; Soliman, MM; Usman, M; Wang, C; Zhao, L, 2022) |
| "Excessive serum uric acid (SUA) causes hyperuricemic nephropathy (HN), characterized by inflammatory infiltration and tubulointerstitial fibrosis." | 4.12 | Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway. ( Chen, Z; Guan, J; Guo, J; Hu, XG; Lan, T; Li, MH; Mo, JX; Wu, KR, 2022) |
| "To assess the effects of anethole on monosodium urate (MSU)-induced inflammatory response, investigate its role in acute gouty arthritis (AGA), and verify its molecular mechanism." | 4.12 | Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway. ( Cao, Y; Liu, Z; Tang, F; Yao, X; Zhang, X; Zhong, Q, 2022) |
| "Despite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation." | 4.02 | Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status. ( Ahn, YM; Lee, H; Rhee, SJ, 2021) |
| " Serum uric acid was obtained to determine hyperuricemia levels." | 4.02 | Dietary Inflammatory Index and the Risk of Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents. ( Aihemaitijiang, S; Halimulati, M; Huang, X; Wang, R; Ye, C; Zhang, Z, 2021) |
| "Lychnopholide, eremantholide C, and goyazensolide improved the inflammation induced by MSU crystals by inhibiting the migration of neutrophils to the inflamed area and by blocking the release of the pro-inflammatory cytokine TNF-α." | 4.02 | Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout. ( Barros, CH; Bernardes, ACFPF; Costa, DC; de Oliveira Aguiar Soares, RD; de Paula Michel Araújo, MC; Matosinhos, RC; Sachs, D; Saúde-Guimarães, DA, 2021) |
| " This study investigated the effects of two neutral CB1 receptor antagonists, AM6545 and AM4113, on nephropathy associated with metabolic syndrome (MetS)." | 4.02 | Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome. ( Aldawsari, HM; Binmahfouz, L; Eid, BG; El-Aziz, GA; El-Bassossy, HM; Hanafy, A; Hasan, A; Makriyannis, A; Neamatallah, T; Vemuri, K, 2021) |
| " We observed an improvement of renal function biomarkers (estimated-glomerular filtration rate, albuminuria, azotemia, uric acid), lipid profile, oxidative stress, inflammatory parameters (erythrocyte sedimentation rate, C-reactive protein) and in body composition at T1." | 4.02 | Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients. ( Di Daniele, F; Di Daniele, N; Di Lauro, M; Marrone, G; Noce, A; Pietroboni Zaitseva, A; Romani, A; Urciuoli, S, 2021) |
| "The current work explored the influences of nifuroxazide, an in vivo inhibitor of signal transducer and activator of transcription-3 (STAT-3) activation, on tubulointerstitial fibrosis in rats with obstructive nephropathy using unilateral ureteral obstruction (UUO) model." | 4.02 | Nifuroxazide suppresses UUO-induced renal fibrosis in rats via inhibiting STAT-3/NF-κB signaling, oxidative stress and inflammation. ( Hassan, NME; Said, E; Shehatou, GSG, 2021) |
| "Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues." | 4.02 | Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage. ( Cho, YY; Choi, N; Jang, JH; Kang, HC; Lee, HS; Lee, JY; Yang, G, 2021) |
| "Hyperuricemia (HUA) is induced by abnormal purine metabolism and elevated serum uric acid (UA) concentrations, and it is often accompanied by inflammatory responses and intestinal disorders." | 4.02 | Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis. ( Hu, N; Lin, Y; Wang, J; Wang, S; Wang, X; Zhang, B; Zhao, X; Zhou, X, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 4.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)." | 4.02 | Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021) |
| " The present study assessed the ability of taurine (TAU) to alleviate or prevent AMK-induced nephrotoxicity if co-administrated with AMK focusing on inflammation, apoptosis, and fibrosis." | 4.02 | The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation. ( Azmy, A; El-Amir, A; Madbouly, N; Salama, A, 2021) |
| " The effects of phloretin on renal function, fibrosis, oxidative stress, inflammation, and UA metabolism in HUA mice were evaluated." | 3.96 | Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption. ( Chen, Y; Cheng, J; Cui, D; Li, L; Liu, J; Liu, S; Lu, Y; Mao, R; Tang, M; Wang, C; Yuan, Y; Zhao, M, 2020) |
| "Eucalyptol alleviates MSU-induced pain and inflammation via mechanisms possibly involving anti-oxidative effect." | 3.96 | Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. ( Li, X; Li, Y; Liu, B; Tai, Y; Wang, C; Wang, P; Yin, C; Zheng, X, 2020) |
| "The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo." | 3.96 | Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. ( Hosoyamada, M; Kimura, Y; Kono, H; Onda, A; Tsukui, D; Yanagida, T, 2020) |
| " Here, we reported that dehydrocostus lactone (DCL), a main component of Saussurea lappa from the traditional Chinese medicine, inhibited NLRP3 inflammasome-mediated caspase-1 activation and subsequent interleukin (IL)-1β production in primary mouse macrophages and human peripheral blood mononuclear cells and exerted an inhibitory effect on NLRP3-driven inflammation." | 3.96 | Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo. ( Ai, Y; Bai, Z; Chen, Y; Hou, X; Li, R; Shi, W; Sun, H; Wang, C; Wang, JB; Wang, Z; Xiao, X; Xu, G; Zhan, X, 2020) |
| "As the KL-VS haplotype alters secretion and activity of KLOTHO and uric acid (UA) is associated with endothelial dysfunction and inflammation, their mutual links may contribute to microalbuminuria (MA) in patients with type 1 diabetes (T1D)." | 3.96 | A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents. ( Gabig-Cimińska, M; Myśliwiec, M; Ryba-Stanisławowska, M; Skrzypkowska, M; Słomiński, B, 2020) |
| "The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multimolecular complex that generates interleukin (IL)-1β and is considered a main pathogenic mechanism for uric acid-induced inflammation." | 3.96 | Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1β Production Through Monosodium Urate-Induced Mitochondrial DNA. ( Choe, JY; Kim, SK; Park, KY, 2020) |
| " Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammation." | 3.96 | Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages. ( Jiang, M; Jiao, JY; Li, Y; Lian, LH; Lin, YC; Liu, J; Nan, JX; Piao, MH; Qiao, CY; Shang, Y; Sun, RH; Wu, YL; Ye, H; Zhan, ZY; Zhang, ZH, 2020) |
| "Compared to hyperuricaemia model or acute gout model, the compound gout model showed little advantages of elevating serum uric acid, causing foot swelling and gout inflammation, while it caused more severe serum inflammation and gut microbiota dysbiosis." | 3.96 | Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice. ( He, Z; Lin, X; Shao, T; Wang, M; Wen, C; Wen, X, 2020) |
| "BACKGROUND This study was to investigate the correlation between osteoporosis and serum uric acid in ankylosing spondylitis (AS) patients, and to further identify potential factors that might be associated with osteoporosis in AS patients." | 3.91 | Serum Uric Acid Shows Inverted "U" Type Correlation with Osteoporosis in Chinese Ankylosing Spondylitis Patients: A Retrospective Study. ( Chen, YT; Chen, Z; Lin, C; Liu, X; Song, P; Wu, Y; Xu, Q; Yang, P; Yang, Y, 2019) |
| "Uric acid is persistently high after HS and leads to the activation of caspases-8 and organ inflammation; these can be prevented by an intervention to degrade UA." | 3.91 | Caspase-(8/3) activation and organ inflammation in a rat model of resuscitated hemorrhagic shock: A role for uric acid. ( Baril, F; Bouchard, C; Brochiero, E; Cardinal, AM; Charbonney, E; Dunberry-Poissant, S; Gilbert, K; Khazoom, F; Rousseau, G; Vega, MA, 2019) |
| "Hyperuricemia is an important risk factor for vascular inflammation, yet the potential mechanisms of uric acid (UA) in endothelial cells are not well understood." | 3.91 | Uric acid induced inflammatory responses in endothelial cells via up-regulating(pro)renin receptor. ( Cheng, Y; Gu, J; Jiang, Y; Li, H; Liu, Y; Lv, H; Yang, X, 2019) |
| "These results indicated that curcumin could effectively ameliorate MSU crystal-induced gouty arthritis through NLRP3 inflammasome mediation via inhibiting NF-κB signaling both in vitro and in vivo, suggesting a promising active ingredient for the prevention and treatment of gouty arthritis." | 3.91 | Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling. ( He, X; Li, X; Sun, DY; Xiao, DM; Xu, DQ; Zhang, T, 2019) |
| "Gouty arthritis is an inflammatory disease that is triggered by abnormal uric acid metabolism, which is usually attributed to obesity, a risk factor of hyperuricemia and gout attack." | 3.91 | Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout. ( Fu, S; Liang, M; Lv, L; Wan, W; Xuan, D; Xue, Y; Yang, J; Yu, Y; Zhu, X; Zou, H, 2019) |
| " Following a low-calorie diet with a lower glycemic index is proposed to silence inflammation by increasing the concentration of uric acid." | 3.91 | A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS). ( Drozd, R; Szczuko, M; Zapalowska-Chwyć, M, 2019) |
| " We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation." | 3.91 | Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis. ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Park, YB; Yang, G, 2019) |
| "This study revealed that artemisinin inhibited activation of NLRP3 inflammasome by suppressing interaction between NEK7 and NLRP3 in uric acid-induced inflammation." | 3.91 | Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. ( Choe, JY; Kim, SK; Park, KY, 2019) |
| "Conflicting results suggest a link between serum uric acid (SUA), inflammation and glucose/insulin homeostasis; however, the role of adiposity in this relationship is not clear." | 3.88 | The link between insulin resistance parameters and serum uric acid is mediated by adiposity. ( Banach, M; Katsiki, N; Mazidi, M; Mikhailidis, DP, 2018) |
| "Pre-eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger-sensing pattern recognition receptors (PRRs)." | 3.88 | Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. ( Aune, MH; Bjørge, L; Dahlberg, UE; Gierman, LM; Iversen, AC; Nervik, I; Silva, GB; Stødle, GS; Sun, C; Tangerås, LH; Thomsen, LCV, 2018) |
| " Both Diosmin and Crocin improved insulin resistance, decreased blood pressure, uric acid, lipoproteins and blocked diabetic nephropathy as indicated by reduction of albumin excretion rate and albumin/creatinine ratio." | 3.88 | Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation. ( El Fayoumi, HM; El-Fawal, R; Mahmoud, MF, 2018) |
| "Aim To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevated CRP (predictor of worse cardiovascular outcomes)." | 3.88 | A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction. ( Brizić, I; Čaušević, A; Jelić Knezović, N; Marković Boras, M; Mikulić, I; Vasilj, M, 2018) |
| " We performed this study to investigate the role of HMGB1 in the pathogenesis of uric acid-induced inflammation in human U937 macrophages." | 3.88 | High-mobility group box 1 is responsible for monosodium urate crystal-induced inflammation in human U937 macrophages. ( Choe, JY; Choi, CH; Kim, SK; Park, KY, 2018) |
| " We injected uric acid intraperitoneally, 125mg/kg/day for 7 days (UA7) and 14 days (UA14), to induce hyperuricemia and then gave allopurinol 50mg/kg/day for 7 days to lower serum uric acid levels (UA7AL7 and UA14AL7)." | 3.88 | Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model. ( Arfian, N; Haryono, A; Nugrahaningsih, DAA; Romi, MM; Sari, DCR, 2018) |
| "Uric acid (UA) has been associated with renal fibrosis and progression of chronic kidney disease." | 3.85 | Uric acid activates NRLP3 inflammasome in an in-vivo model of epithelial to mesenchymal transition in the kidney. ( De Paul, AL; Latini, A; Mukdsi, JH; Remor, A; Romero, CA; Torres, AI, 2017) |
| "Procyanidins significantly attenuated gout pain and suppressed ankle swelling." | 3.85 | Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. ( Fan, YX; Gui, X; Han, Y; Hu, L; Jiang, CY; Liu, BQ; Liu, HJ; Liu, WT; Pan, XX; Tang, YL, 2017) |
| "We aimed to evaluate whether total dietary antioxidant capacity (assessed by dietary ferric reducing antioxidant potential (FRAP)), serum uric acid (UA) and gamma glutamyltransferase (GGT) were associated with low-grade chronic inflammation and circulating adipocytokines." | 3.85 | Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study. ( Brahimaj, A; Dehghan, A; Franco, OH; Hofman, A; Ikram, MA; Kiefte-de Jong, JC; Muka, T; Stringa, N; Zaciragic, A, 2017) |
| "XO inhibition significantly attenuated WD-induced increases in plasma uric acid, vascular XO activity and oxidative stress, in concert with reductions in proteinuria." | 3.85 | Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice. ( Aroor, AR; Brady, B; Chen, D; Demarco, VG; Habibi, J; Jia, G; Manrique, C; Martinez-Lemus, LA; Meininger, GA; Nistala, R; Ramirez-Perez, FI; Sowers, JR; Sun, Z; Whaley-Connell, AT, 2017) |
| "Several pieces of evidence have linked the involvement of xanthine oxidase (XO), a source of uric acid and reactive oxygen species (ROS), to pro-oxidative and pro-inflammatory effects observed during bacterial fish diseases." | 3.85 | Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae. ( Baldissera, MD; Baldisserotto, B; Doleski, PH; Santos, RCV; Souza, CF; Verdi, CM; Vizzotto, BS, 2017) |
| "Uric acid (UA) plays important roles in inducing renal inflammation, intra-renal vasoconstriction and renal damage." | 3.85 | Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation. ( Arfian, N; Romi, MM; Sari, DCR; Setyaningsih, WAW; Tranggono, U, 2017) |
| "Patients with psoriasis have increased systemic inflammation and serum uric acid (SUA) levels compared with the general population." | 3.85 | Impact of Elevated Serum Uric Acid Levels on Systemic Inflammation in Patients With Psoriasis. ( Dikicier, BS; Erdem, T; Solak, B, 2017) |
| "Using mass spectrometry, oxidation products of glutathione and uric acid were measured in matched samples of bronchoalveolar lavage (BAL), serum and urine from 36 infants and children with CF, and related to markers of neutrophilic inflammation and infection in BAL." | 3.85 | Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. ( Dickerhof, N; Fantino, E; Kettle, AJ; Khalilova, I; Sly, PD; Turner, R, 2017) |
| "Uric acid is a risk factor for coronary artery disease in postmenopausal women, but the association with inflammation and coronary endothelial dysfunction (CED) is not well defined." | 3.85 | Uric Acid Is Associated With Inflammation, Coronary Microvascular Dysfunction, and Adverse Outcomes in Postmenopausal Women. ( Gulati, R; Herrmann, J; Lerman, A; Lerman, LO; Matteson, EL; Prasad, M; Rihal, CS, 2017) |
| "Elevated serum uric acid (SUA) level is strongly associated with prevalence of metabolic syndrome (MS), elevated parathyroid hormone (PTH) levels, and 25-hydroxyvitamin D [25(OH)D] insufficiency in adults." | 3.83 | Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. ( Alemzadeh, R; Kichler, J, 2016) |
| "The aim of this study was to investigate the anti-inflammatory effect of ferulic acid, a dietary phenol, on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis." | 3.83 | Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats. ( Dey, C; Doss, HM; Rasool, MK; Sudandiradoss, C, 2016) |
| " Plasma MED concentrations, inflammation and oxidative stress indices [Kynurenine/Tryptophan (Kyn/Trp) ratio, malondialdehyde (MDA) and allantoin/uric acid (All/UA) ratio] were measured in 30 CKD patients randomized to three cholesterol lowering regimens for 12 months (simvastatin 40mg/day, ezetimibe/simvastatin 10/20mg/day, or ezetimibe/simvastatin 10/40mg/day)." | 3.83 | Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease. ( Carru, C; Ena, S; Mangoni, AA; Satta, AE; Sotgia, S; Sotgiu, E; Zinellu, A, 2016) |
| " The effects and possible molecular mechanisms of astilbin on potassium oxonate-induced hyperuricemia mice were investigated in this study." | 3.83 | Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice. ( Chen, J; Wang, M; Zhang, N; Zhao, J, 2016) |
| "The association between serum uric acid concentrations and inflammation in patients with rheumatoid arthritis (RA) has been still controversial." | 3.81 | Association between serum uric acid and inflammation in rheumatoid arthritis: perspective on lowering serum uric acid of leflunomide. ( Choe, JY; Kim, SK, 2015) |
| " We investigated the role of soluble uric acid in NLRP3 inflammasome activation in macrophages to demonstrate the effect of systemic hyperuricemia on progressive kidney damage in type 2 diabetes." | 3.81 | Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy. ( Choi, YW; Ihm, CG; Jeong, KH; Kim, DJ; Kim, SM; Kim, SY; Kim, YG; Lee, SH; Lee, TW; Moon, JY; Seo, JW; Won, KY, 2015) |
| "To assess serum levels and correlation between uric acid (UA) and C-reactive protein (CRP) in acute coronary syndrome (ACS) and apparently healthy individuals." | 3.81 | Positive correlation between uric acid and C-reactive protein serum level in healthy individuals and patients with acute coronary syndromes. ( Hasić, S; Kiseljaković, E; Kulić, M; Resić, H; Spahić, E, 2015) |
| "To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation." | 3.81 | Uric acid correlates to oxidation and inflammation in opposite directions in women. ( Cai, Q; Chen, H; Fazio, S; Gao, YT; Linton, MF; Milne, G; Purdue, M; Rothman, N; Shu, XO; Wu, SH; Xiang, YB; Yang, G; Zhang, X; Zheng, W, 2015) |
| "Gout is an acute inflammatory disease characterised by the presence of uric acid crystals in the joint." | 3.81 | Oral treatment with Bifidobacterium longum 51A reduced inflammation in a murine experimental model of gout. ( Amaral, FA; Galvão, I; Martins, FS; Nicoli, JR; Teixeira, MM; Vieira, AT, 2015) |
| "Among adults free of metabolic syndrome, elevated uric acid, but not elevated CRP, is independently associated with prevalent hypertension." | 3.80 | Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010. ( Krishnan, E, 2014) |
| "The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation." | 3.80 | The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. ( Arts, IC; Boonen, A; Dagnelie, PC; Ferreira, I; Feskens, EJ; Schalkwijk, CG; Stehouwer, CD; van der Kallen, CJ; van der Linden, S; van Greevenbroek, MM; Wijnands, JM, 2014) |
| "The aim of this study was to investigate the effects of pravastatin and nebivolol in the atherosclerotic process including inflammation and oxidative stress in rat aorta." | 3.80 | The anti-inflammatory and antioxidant effects of pravastatin and nebivolol in rat aorta. ( Aktaş, SG; Atay, A; Çuhadar, S; Dursun, S; Köseoğlu, M, 2014) |
| " Further, an acetic acid-induced writhing test and tail immersion test were employed to screen for analgesic effects, yeast-induced pyrexia was used to test for antipyretic effects, and gastric ulceration was used to evaluate ulcerogenic effects." | 3.79 | Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats. ( Pragasam, SJ; Rasool, M, 2013) |
| " High uricemia in humans may protect against oxidative stress, but hyperuricemia also associates with the metabolic syndrome, and urate and uric acid can crystallize to cause gout and renal dysfunctions." | 3.79 | Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice. ( Bazin, D; Da Costa, A; Daudon, M; Dessombz, A; Laverriere-Loss, A; Metref, S; Moret, C; Preitner, F; Rotman, S; Sandt, C; Thorens, B, 2013) |
| " The feed intake, body weight, blood glucose, interleukin 2 (IL-2), interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-alpha), haematological parameters, serum lipid profile and uric acid, liver reduced glutathione and malodialdehyde were determined." | 3.79 | Immunomodulatory activities of Yoyo bitters: recommended dose precipitated inflammatory responses in male Wistar rats. ( Adebisi, JA; Adetutu, A; Oyewo, EB, 2013) |
| " The higher CRP group was discriminated by the above variables in addition to lower VO(2max), serum metabolic syndrome components (triglycerides, glucose, and HDL cholesterol), higher insulin, homeostasis assessment of insulin resistance, uric acid, gamma-GT, and homocysteine." | 3.79 | Pathological and behavioral risk factors for higher serum C-reactive protein concentrations in free-living adults--a Brazilian community-based study. ( Burini, RC; de Oliveira, EP; Manda, RM; Michelin, E; Moreto, F; Teixeira, O; Torezan, GA, 2013) |
| "Acute gout is associated with a decrease in serum uric acid (SUA) that is considered to be in response to acute inflammation but it may be a feature of gout itself." | 3.79 | The effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on serum uric acid in patients without gout: a prospective study. ( Ashby, HL; Chugh, S; Deshpande, S; Ford, C; Gama, R; Razavi, C; Thomas, OL; Waldron, JL, 2013) |
| "Uric acid (UA) is independently associated with the emergence of hypertension." | 3.79 | Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. ( Aydoğdu, S; Işleyen, A; Johnson, RJ; Kanbay, M; McFann, K; Ozcan, F; Sen, N; Sökmen, E; Taşoğlu, I; Tok, D; Turak, O, 2013) |
| " In the present study, we found that treatment with lemnalol (intramuscular [im]), but not colchicine (oral [po]), significantly attenuated MUS-induced mechanical allodynia, paw edema and knee swelling." | 3.79 | Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression. ( Duh, CY; Huang, SY; Jean, YH; Lee, HP; Lin, YY; Wang, HM; Wen, ZH; Wu, SF, 2013) |
| "Elevated serum uric acid has been associated with a variety of cardiovascular disease and with inflammation, but these have been little explored in chronic kidney disease (CKD)." | 3.79 | Is there association between uric acid and inflammation in hemodialysis patients? ( Carraro-Eduardo, JC; da Nóbrega, AC; Lobo, JC; Mafra, D; Stockler-Pinto, MB, 2013) |
| "To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in mice." | 3.78 | Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice. ( Indu, H; Rasool, M; Sabina, EP, 2012) |
| "Elevated serum uric acid is not associated with endothelial dysfunction among healthy adults, but is inversely related to EID and EC MnSOD, and positively related to systemic inflammation." | 3.78 | Vascular endothelial function is not related to serum uric acid in healthy adults. ( Chonchol, MB; Jablonski, KL; Jalal, DI; McFann, K; Seals, DR, 2012) |
| " trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation." | 3.78 | Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. ( de Paula, CA; de Souza Filho, JD; de Souza, MR; Grabe-Guimarães, A; Pereira de Resende, ML; Saúde-Guimarães, DA, 2012) |
| "To explore the correlations between serum uric acid (UA) levels and the clinical and cerebrospinal fluid (CSF) parameters of multiple sclerosis (MS)." | 3.78 | Correlations between serum uric acid level and disease activity, intrathecal inflammation reactivity in patients with multiple sclerosis. ( Chen, XW; Cui, LY; Liu, CY; Peng, B; Wang, JM; Xu, Y; Zhong, LZ, 2012) |
| "These results indicated that quercetin exerted a strong anti-inflammatory effect that may be useful for the treatment of acute gouty arthritis." | 3.78 | Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. ( Chen, J; Huang, J; Li, S; Sun, W; Tao, Y; Wang, S; Zhu, M, 2012) |
| "The data regarding the role of serum uric acid (SUA) along with subclinical inflammation in the context of hypertensive vascular damage are rather scarce and controversial." | 3.77 | The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. ( Dimitriadis, K; Katsi, V; Kyvelou, S; Lalos, S; Mihas, C; Poulakis, M; Sideris, S; Skiadas, I; Stefanadi, E; Stefanadis, C; Syrseloudis, D; Tsioufis, C, 2011) |
| "Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population." | 3.77 | Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients. ( Chen, Y; Ding, X; Fang, Y; Liu, Z; Shen, B; Teng, J; Wang, Y; Xu, S; Zhong, Y; Zou, J, 2011) |
| " MRFs (serum lipid profile, insulin resistance indexes, blood pressure) in addition to uric acid, homocysteine, leptin, and inflammatory markers were measured." | 3.77 | Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. ( Alonso-Iglesias, E; Codoñer-Franch, P; Megías-Vericat, J; Murria-Estal, R; Tavárez-Alonso, S; Tortajada-Girbés, M, 2011) |
| "To examine the association between renal function, serum uric acid and markers of both pro-inflammatory and prothrombotic state in patients with diabetes mellitus (DM), metabolic syndrome and coronary artery disease." | 3.77 | Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease. ( Buraczyńska, MJ; Kondracki, B; Rychta, E; Waciński, P; Wysokiński, A; Zapolski, T, 2011) |
| "The relation of serum uric acid (SUA) with systemic inflammation has been little explored in humans and results have been inconsistent." | 3.77 | Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. ( Bochud, M; Lyngdoh, T; Marques-Vidal, P; Paccaud, F; Preisig, M; Vollenweider, P; Waeber, G, 2011) |
| "This study aimed to evaluate the association of serum inflammatory markers (C-reactive protein (CRP) and uric acid (UA)), magnesium and other CVD risk factors with insulin resistance (IR) among Chinese postmenopausal women with prediabetes." | 3.77 | The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes. ( Ho, SC; Liu, ZM, 2011) |
| "Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses." | 3.77 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis. ( Chen, DP; Lam, CW; Li, EK; Tam, LS; Wong, CK, 2011) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 3.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| "The concept that intraarticular crystals of uric acid by themselves trigger episodes of painful gouty arthritis is inconsistent with the clinical reality." | 3.76 | Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. ( Giamarellos-Bourboulis, EJ; Joosten, LA; Kanneganti, TD; Koenders, MI; Malireddi, RK; Mylona, E; Netea, MG; Oosting, M; Stalenhoef, AF; Stienstra, R; van de Veerdonk, FL; van der Meer, JW, 2010) |
| "Sarcopenia may be related to increases in reactive oxygen species formation and inflammation, both of which are associated with elevations in serum uric acid." | 3.75 | Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III. ( Beavers, DP; Beavers, KM; Bowden, RG; Serra, MC; Wilson, RL, 2009) |
| " Uric acid derived from hypoxanthine accumulated in infected erythrocytes has been recently proposed as a mediator of inflammation in rodent malaria." | 3.75 | Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. ( Day, K; Evans, B; Evans, JE; Leliwa-Sytek, A; Nyako, M; Orengo, JM; Rodriguez, A; van de Hoef, D, 2009) |
| "The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine and metamizol combination on different levels of nociception (levels I, II, and III) using the "Pain-induced functional impairment model in the rat"." | 3.74 | The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain. ( Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Godínez-Chaparro, B; Guevara-López, U; Huerta-Cruz, JC; López-Muñoz, FJ, 2008) |
| "Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known." | 3.74 | "Dangerous crystals". ( DeFranco, AL, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 3.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| "We examined the associations of serum uric acid (UA) with indices of coronary heart disease (CHD) risk, including the 10-year probability of CHD (10y-CHDr), metabolic syndrome (MS), inflammation (C-reactive protein [CRP] and fibrinogen), and the presence and quantity of coronary artery calcium (CAC)." | 3.74 | Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis. ( Bielak, LF; Coutinho, Tde A; Kullo, IJ; Peyser, PA; Sheedy, PF; Turner, ST, 2007) |
| "The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation." | 3.74 | Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. ( Baumert, J; Döring, A; Koenig, W; Meisinger, C, 2008) |
| "We conducted PubMed/MEDLINE searches (1966-January 2008) of primary literature using the following key words: ACE inhibitors, allopurinol, angiotensin-receptor antagonists, cardiomyopathy, chemokines, cytokines, diuretics, heart failure, inflammation, interleukins, HMG-CoA reductase inhibitors, immunotherapy, medications used in heart failure, thalidomide, tumor necrosis factor, and uric acid." | 3.74 | Inflammation in chronic heart failure. ( Evans, JD; Parish, RC, 2008) |
| "In the nociception test, the pain-induced functional impairment rat model, uric acid at 3." | 3.73 | Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005) |
| "To examine the ability of rofecoxib prophylaxis to blunt the effect of monosodium urate (MSU) crystal inflammation induced in the rat subcutaneous air pouch." | 3.73 | Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch. ( Chen, LX; Clayburne, G; Nalbant, S; Schumacher, HR; Sieck, MS, 2005) |
| "Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues." | 3.73 | Gout-associated uric acid crystals activate the NALP3 inflammasome. ( Martinon, F; Mayor, A; Pétrilli, V; Tardivel, A; Tschopp, J, 2006) |
| "The aim of this study was to test the hypothesis that pulmonary inflammation and emphysema induced by cadmium (Cd) inhalation are associated with pulmonary oxidative stress." | 3.73 | Airway inflammation in cadmium-exposed rats is associated with pulmonary oxidative stress and emphysema. ( Fievez, L; Gustin, P; Kirschvink, N; Marlin, D; Martin, N; Smith, N, 2006) |
| "Abdominal obesity is the main determinant of uric acid variance." | 3.73 | Serum uric acid is a determinant of metabolic syndrome in a population-based study. ( Albayrak, S; Hergenç, G; Karabulut, A; Keleş, I; Onat, A; Sari, I; Uyarel, H; Yazici, M, 2006) |
| " To determine whether this is a reflection of the physiological contribution of ONOO(-) to an immune response against a neurotropic pathogen, we have assessed the effects on adult rats acutely infected with Borna disease virus (BDV) of administration of uric acid (UA), an inhibitor of select chemical reactions associated with ONOO(-)." | 3.71 | The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent. ( Bette, M; Dietzschold, B; Hooper, DC; Kean, RB; Mikheeva, T; Morimoto, K; Röhrenbeck, AM; Scott, GS; Spitsin, SV; Weihe, E, 2001) |
| ", anorexia nervosa and alcoholism, and the mechanisms by which increased uric acid level may be explained." | 3.70 | Tophaceous gout of the navicular bone as a cause of medial inflammatory tumor of the foot. ( Baldet, P; Blotman, F; Bonnel, F; Canovas, F; Leroux, JL; Medioni, D; Olive, P; Thomas, E, 1998) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 3.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| " In this study, we show that the inflammatory microcrystals monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD), the major mediators of gout and pseudogout, differentially regulate the production of these two chemokines by human neutrophils." | 3.69 | Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. ( Hachicha, M; McColl, SR; Naccache, PH, 1995) |
| "Accumulating evidence implicates interleukin-8 (IL-8) as an essential mediator in neutrophil-mediated acute inflammation." | 3.69 | Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8. ( Akahoshi, T; Itoman, M; Kondo, H; Matsushima, K; Mukaida, N; Nishimura, A; Takagishi, K; Takahashi, M; Takahashi, Y; Yokoi, K, 1997) |
| "A subcutaneous air pouch formed in Sprague-Dawley rats was used to study the effect of diets enriched in gamma-linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals." | 3.67 | Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. ( Baker, DG; Karmali, RA; Laposata, M; Mandell, BF; Schumacher, HR; Tate, GA; Zurier, RB, 1988) |
| "Colchicine, given locally, inhibits urate-crystal- and CaPPD-crystal-induced inflammation." | 3.65 | Anti-prostaglandin action of colchicine. ( Denko, CW, 1975) |
| "Hyperuricemia is associated with the activation of the Nod-like receptor protein 3 inflammasome." | 3.30 | C-reactive Protein Levels and Cardiovascular Outcomes After Febuxostat Treatment in Patients with Asymptomatic Hyperuricemia: Post-hoc Analysis of a Randomized Controlled Study. ( Hayashi, T; Hiramitsu, S; Hisatome, I; Jinnouchi, H; Kakuda, H; Kawai, N; Kimura, K; Kojima, S; Matsui, K; Mori, H; Ogawa, H; Ohya, Y; Saito, Y; Sugawara, M; Tokutake, E; Tsujita, K; Uchiyama, K; Wakasa, Y; Waki, M; Yokota, N, 2023) |
| "Gout is triggered by high urate levels and causes inflammation, pain, and an impaired quality of life." | 3.30 | Immersion in Water Between 20-30 ( Chou, KR; Karwur, FF; Kurniasari, MD; Miao, NF; Rayanti, RE; Shen, CJ; Shih, YW; Tsai, HT; Yuliana, S, 2023) |
| "If untreated, acute gout may eventually develop into chronic tophaceous gout characterized by tophi, chronic gouty synovitis, and structural joint damage, leading the crushing burden of treatment." | 3.01 | A review on gout: Looking back and looking ahead. ( Liu, W; Mo, Y; Tao, H; Wang, H, 2023) |
| "Gout is an autoimmune disease characterized by acute or chronic inflammation and damage to bone joints induced due to the precipitation of monosodium urate (MSU) crystals." | 3.01 | Immune and inflammatory mechanisms and therapeutic targets of gout: An update. ( Li, H; Liu, W; Peng, J; Wu, R; Wu, Y; Ye, Z; Zong, Z, 2023) |
| "Uric acid has been linked with increased risk of chronic disease such as cardiovascular disease and this association has been attributed to a pro-inflammatory effect." | 2.84 | A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study. ( Becker, KG; Ferrucci, L; Milaneschi, Y; Tanaka, T; Zhang, Y; Zukley, L, 2017) |
| "Hepatic inflammation is prevalent in several metabolic liver diseases." | 2.82 | The contribution of sterile inflammation to the fatty liver disease and the potential therapies. ( Shaker, ME, 2022) |
| " To investigate the potency of MSU crystals as a cancer vaccine carrier in vivo, this preclinical study examined whether intradermal injection of MSU crystals was safe for healthy adults." | 2.76 | Safety of intradermal injection of monosodium urate crystals as a vaccine carrier in volunteers. ( Inai, K; Sakamaki, I; Tsutani, H, 2011) |
| "Inflammation was reduced in the cherry juice group (IL-6, P<0." | 2.75 | Influence of tart cherry juice on indices of recovery following marathon running. ( Brouner, J; Hill, JA; Howatson, G; Howatson, SA; Jewell, AP; McHugh, MP; Shave, RE; van Someren, KA, 2010) |
| "Uric acid levels were significantly reduced at both 7 days and 6 weeks in the high-dose group (by 0." | 2.73 | Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial. ( Dawson, J; Harrow, C; Lees, KR; Muir, SW; Sattar, N; Walters, MR; Weir, CJ, 2008) |
| "Hyperuricemia is the main risk factor for gout and is linked to the development of comorbidities." | 2.66 | Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia. ( Cabău, G; Crișan, TO; Joosten, LAB; Klück, V; Popp, RA, 2020) |
| "Gout is both an inflammatory and a metabolic disease." | 2.55 | Gout and Metabolic Syndrome: a Tangled Web. ( Krasnokutsky, S; Pillinger, MH; Thottam, GE, 2017) |
| "Acute kidney injury is a frequent complication among ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI), and is associated with adverse outcomes." | 2.53 | Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: a multifactorial entity. ( Arbel, Y; Shacham, Y; Steinvil, A, 2016) |
| "Hyperuricemia has been widely accepted to be associated with the incidence of paroxysmal or persistent AF, as well as to the risk of AF in post cardiovascular surgery patients." | 2.53 | Hyperuricemia and Atrial Fibrillation. ( Hisatome, I; Kuwabara, M; Maharani, N, 2016) |
| "The pharmacological treatment of pain in CIA is strictly associated with the treatment of acute phases and flares of the disease, during which crystals trigger the inflammatory response." | 2.52 | Molecular mechanisms of pain in crystal-induced arthritis. ( Frallonardo, P; Galozzi, P; Lorenzin, M; Oliviero, F; Ortolan, A; Punzi, L; Ramonda, R; Scanu, A, 2015) |
| "Acute gout is an auto-inflammatory disease characterized by self-limiting inflammation in response to the deposition of monosodium urate (MSU) crystals in the joints or tissues." | 2.50 | Mechanisms of spontaneous resolution of acute gouty inflammation. ( Harper, JL; Steiger, S, 2014) |
| "Uric acid is an important contributor to inflammatory cytokine secretion, dendritic cell and T cell responses induced by Plasmodium, suggesting uric acid as a novel molecular target for anti-inflammatory therapies in malaria." | 2.50 | A surprising role for uric acid: the inflammatory malaria response. ( Gallego-Delgado, J; Orengo, JM; Rodriguez, A; Ty, M; van de Hoef, D, 2014) |
| "Gout is a common inflammatory arthritis precipitated by an inflammatory reaction to urate crystals in the joint." | 2.50 | Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities. ( Horsburgh, S; Robinson, PC, 2014) |
| "A major challenge in preventing diabetic nephropathy is the inability to identify high-risk patients at an early stage, emphasizing the importance of discovering new therapeutic targets and implementation of clinical trials to reduce diabetic nephropathy risk." | 2.50 | Early diabetic nephropathy in type 1 diabetes: new insights. ( Bjornstad, P; Cherney, D; Maahs, DM, 2014) |
| "Hyperphosphatemia is a major problem in these patients especially at advanced stages of CKD, and it is associated with cardiovascular and mineral complications in these patients." | 2.50 | [Pleiotropic effects of sevelamer: a model of intestinal tract chelating agent]. ( Maizel, J; Massy, ZA, 2014) |
| "Uric acid is a waste product of purine catabolism." | 2.49 | Uric acid as a danger signal in gout and its comorbidities. ( Kataoka, H; Lai, JJ; Rock, KL, 2013) |
| "Acute inflammation is the hallmark of the acute tissue reaction to crystals in both gout and pseudogout." | 2.48 | The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis). ( Busso, N; Ea, HK, 2012) |
| "Uric acid has been identified as an endogenous adjuvant that drives immune responses in the absence of microbial stimulation." | 2.47 | The role of uric acid as an endogenous danger signal in immunity and inflammation. ( Ghaemi-Oskouie, F; Shi, Y, 2011) |
| "An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation." | 2.46 | Mechanisms of inflammation in gout. ( Busso, N; So, A, 2010) |
| "Gout is a disease caused by the deposition of monosodium urate monohydrate crystals." | 2.44 | Recent advances in crystal-induced acute inflammation. ( Akahoshi, T; Kitasato, H; Murakami, Y, 2007) |
| "Gouty arthritis is a characteristically intense acute inflammatory reaction that erupts in response to articular deposits of monosodium urate (MSU) crystals." | 2.43 | The inflammatory process of gout and its treatment. ( Cronstein, BN; Terkeltaub, R, 2006) |
| "MSU-associated inflammation is majorly triggered by NOD-like receptor protein 3 (NLRP3) inflammasome that promotes interleukin (IL)-1β secretion." | 1.91 | Diallyl trisulfide inhibits monosodium urate-induced NLRP3 inflammasome activation via NOX3/4-dependent mitochondrial oxidative stress in RAW 264.7 and bone marrow-derived macrophages. ( Bang, E; Choi, YH; Hong, SH; Hwangbo, H; Ji, SY; Kim, DH; Kim, GY; Kim, MY; Lee, H; Park, C, 2023) |
| "Totally, 290 CAPD-ESRD patients and 50 healthy controls (HCs) were recruited, and their serum omentin-1 levels were measured by enzyme-linked immunosorbent assay." | 1.91 | Correlation of serum omentin-1 level with clinical features and major adverse cardiac and cerebral events in patients undergoing continuous ambulatory peritoneal dialysis. ( Liu, J; Ou, J; Yao, C; Zhou, L, 2023) |
| " Thereby, we used a biological model species-Japanese quail (Coturnix japonica) to examine the nephrotoxic effects of Pb exposure and possible toxic mechanism of Pb on birds." | 1.91 | Lead exposure induced developmental nephrotoxicity in Japanese quail (Coturnix japonica) via oxidative stress-based PI3K/AKT pathway inhibition and NF-κB pathway activation. ( Jing, L; Zhang, G; Zhang, Y; Zhao, H, 2023) |
| "Acute gouty arthritis is inflammatory joint arthritis." | 1.91 | Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies. ( Fu, W; Ge, M; Li, J, 2023) |
| "Gout is an inflammatory arthritis initiated by the deposition of monosodium urate crystals (MSU) around the joints and surrounding tissues." | 1.91 | A wild rice-derived peptide R14 ameliorates monosodium urate crystals-induced IL-1β secretion through inhibition of NF-κB signaling and NLRP3 inflammasome activation. ( Chanjitwiriya, K; Charoenwutthikun, S; Kunthalert, D; Roytrakul, S, 2023) |
| "Hyperuricemia was defined by serum uric acid level." | 1.91 | The correlation between dietary inflammatory index and risk of hyperuricemia in the U.S. population. ( Bao, K; Hong, X; Huang, X; Li, P; Liu, H; Wang, D; Wang, L; Wang, Y; Zhao, D, 2023) |
| "Hyperuricemia is an independent risk factor for chronic kidney disease." | 1.91 | Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction. ( Cao, H; Chen, Q; Li, K; Liu, L; Liu, M; Wang, D; Wang, T; Wu, Y; Zhang, Y, 2023) |
| "Gouty arthritis is characterized by chronic deposition of monosodium urate (MSU) crystals in the joints and other tissues, resulting in the production of excess reactive oxygen species (ROS) and proinflammatory cytokines that intensify synovial inflammation." | 1.91 | Targeted treatment of gouty arthritis by biomineralized metallic nanozyme-mediated oxidative stress-mitigating nanotherapy. ( Chahal, S; Mohanty, A; Mohapatra, A; Park, IK; Rajendrakumar, SK; Sathiyamoorthy, P; Vijayan, V, 2023) |
| "Gout is a common metabolic disorder characterized by deposits of monosodium urate monohydrate crystals (tophi) in soft tissue, triggering intense and acute arthritis with intolerable pain as well as articular and periarticular inflammation." | 1.91 | Identification of tophi in ultrasound imaging based on transfer learning and clinical practice. ( Chang, CC; Chang, CK; Lee, HY; Lin, KH; Lin, TM; Peng, SJ; Wu, BF, 2023) |
| "Chronic inflammation is an important factor for CKD progression." | 1.91 | Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio. ( Huang, HS; Liu, CJ; Liu, CM; Lu, ZH; Tung, HT, 2023) |
| "Gouty arthritis is characterized by painful inflammation due to the deposition of monosodium urate crystals in joint tissues." | 1.91 | Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model. ( Bertolini, GRF; Costa, RM; Hoss, IM; Leal, TSDS; Pradal, LA; Ribeiro, LFC, 2023) |
| "And gout and hyperuricemia are also possible connection with cardiovascular disease and metabolic syndrome." | 1.72 | Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity. ( Dai, LJ; He, FX; Luo, LS; Wang, Y; Zhang, JL; Zhou, Q, 2022) |
| "Asymptomatic hyperuricemia is prevalent among young adults and associated with markers of prediabetes, dyslipidemia, and subclinical inflammation." | 1.72 | Prevalence of asymptomatic hyperuricemia and its association with prediabetes, dyslipidemia and subclinical inflammation markers among young healthy adults in Qatar. ( Al Shanableh, Y; Al-Mansoori, A; Al-Mohannadi, M; Aljalham, B; Hussein, YY; Nurulhoque, H; Robelah, F; Saidwali, AH; Zughaier, SM, 2022) |
| "Melatonin (MLT) is a powerful endogenous anti-inflammatory agent and effective in reducing cellular damage." | 1.72 | Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis. ( Altinoz, E; Ballur, AFH; Bicer, Y; Demir, M; Elbe, H; Karayakali, M; Onal, MO; Yigitturk, G, 2022) |
| "Low-grade inflammation has been postulated to have a key role in the pathogenesis of MetS and has been linked to insulin resistance (IR)." | 1.72 | Association Between Low-Grade Inflammation and Hyperuricemia in Adults With Metabolic Syndrome in Yucatán, México. ( Avila-Nava, A; Banik, SD; Chim Aké, R; Gutiérrez Solis, AL; Lugo, R, 2022) |
| "Gout is a common arthritis caused by deposition of monosodium urate crystals." | 1.72 | Natural Adrenocorticotropic Hormone (ACTH) Relieves Acute Inflammation in Gout Patients by Changing the Function of Macrophages. ( Cao, L; Liu, J; Wan, W; Xu, R; Xuan, D; Xue, Y; Yu, Y; Zhao, L; Zhao, T; Zou, H, 2022) |
| "Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues." | 1.72 | Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy. ( Jiang, YJ; Lian, LH; Nan, JX; Piao, MH; Wang, H; Wu, YL, 2022) |
| "Resolvin D1 (RvD1) is a specialized pro-resolving lipid mediator with anti-inflammatory and analgesic proprieties." | 1.72 | RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice. ( Amaral, FA; Andrade, KC; Artero, NA; Badaro-Garcia, S; Bertozzi, MM; Borghi, SM; Casagrande, R; Fattori, V; Ferraz, CR; Manchope, MF; Rasquel-Oliveira, F; Rogers, MS; Saraiva-Santos, T; Staurengo-Ferrari, L; Teixeira, MM; Verri, WA; Zaninelli, TH, 2022) |
| "Gout is of unknown reason associated with cardiovascular disease." | 1.72 | Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study. ( Haavardsholm, EA; Hammer, HB; Jensen, G; Karoliussen, LF; Kvien, TK; Rollefstad, S; Semb, AG; Terslev, L; Uhlig, T, 2022) |
| "Geniposide (GEN) is a typical natural iridoid glucoside compound with a series of biological activities, but the poor bioavailability of GEN limits its clinical application." | 1.72 | A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress. ( Chen, JS; Guo, X; Liao, ZX; Liu, C; Liu, JS; Sun, JY; Wang, MM; Wang, MX; Zhang, J; Zhang, MQ, 2022) |
| "Gouty arthritis is an inflammatory disease induced by monosodium urate (MSU), and is closely related to the activation of inflammasomes." | 1.72 | Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF-κB and p62-Keap1 pathways. ( Li, Y; Liu, X; Tian, J; Wang, B; Xiang, L; Xie, B; Zhou, D, 2022) |
| "Gout is a painful form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints." | 1.72 | The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model. ( Aganetti, M; Amaral, FA; Braga, AD; de Faria, AMC; de Oliveira, VLS; Galvão, I; Georgel, P; Martins, VD; Mastrippolito, D; Mendes, V; Muller, S; Rocha, V; Talamini, L; Verdot, C; Vieira, AT, 2022) |
| "Gout is caused by elevated serum urate leading to the deposition of monosodium urate (MSU) crystals that can trigger episodes of acute inflammation." | 1.72 | Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence. ( Astin, JW; Dalbeth, N; Hall, CJ; Linnerz, T; Rolland, L; Sung, YJ, 2022) |
| "Gout is a common inflammatory disease." | 1.72 | Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2. ( Chen, Y; Guo, X; Xia, H; Xu, L; You, CG; Zhao, M; Zhong, X; Zhou, Y, 2022) |
| "Hyperuricemia and gout have become gradually more common." | 1.72 | Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort. ( Cui, J; Lv, Z; Zhang, J, 2022) |
| "High uric acid levels are a risk factor for cardiovascular disorders, and metabolic diseases; however, the role of serum uric acid (sUA) during the mycoplasma pneumoniae pneumonia (MPP) of children is poorly known." | 1.62 | The study of routine laboratory factors in children with mycoplasma pneumoniae pneumonia: serum uric acid may have anti-inflammatory effect. ( Chen, Y; Li, M; Pan, C; Qu, S; Wang, S, 2021) |
| "Hyperuricemia is the primary cause of gouty arthritis and other metabolic disorders." | 1.62 | Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats. ( Kim, DS; Sung, YY, 2021) |
| "Uric acid is an effective antioxidant." | 1.62 | Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway. ( Bi, H; Hao, Z; Lin, Y; Liu, Y; Xia, Y; Xie, Y; Yang, X, 2021) |
| "Inflammation is an important pathological feature of hyperuricemia, which in turn aggravates hyperuricemia." | 1.62 | Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice. ( Chen, Y; Liu, T; Yang, Z; Yuan, F; Zhang, L; Zhang, S; Zhou, X; Zhuang, J, 2021) |
| "Both astrogliosis and microgliosis were observed in the hippocampus and white matter at postnatal day (PND)7 with IL-1Ra being protective." | 1.62 | Prenatal administration of IL-1Ra attenuate the neurodevelopmental impacts following non-pathogenic inflammation during pregnancy. ( Brien, ME; Girard, S; Hughes, K, 2021) |
| "Hyperuricemia is a common metabolic disease that is intimately correlated with inflammation." | 1.62 | Estimate of prevalent hyperuricemia by systemic inflammation response index: results from a rural Chinese population. ( Chen, MQ; Shi, WR; Sun, YX; Wang, HY, 2021) |
| "In the 2369 patients with STEMI considered, 30-day mortality was 5." | 1.62 | Elevated serum uric acid is associated with a greater inflammatory response and with short- and long-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. ( Camporotondo, R; Cornara, S; Crimi, G; De Ferrari, GM; Demarchi, A; Ferlini, M; Ferrario, M; Galazzi, M; Gnecchi, M; Mandurino-Mirizzi, A; Montalto, C; Oltrona-Visconti, L; Puccio, S; Somaschini, A, 2021) |
| "Hyperuricemia was defined as SUA ≥416." | 1.62 | Predictive Value of Thyroid Hormones for Incident Hyperuricemia in Euthyroid Subjects: The Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. ( Gu, Y; Jia, Q; Liu, L; Meng, G; Niu, K; Song, K; Sun, S; Wang, X; Wang, Y; Wu, H; Wu, X; Zhang, Q; Zhang, S; Zhang, T; Zhou, M, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with few therapeutic options available currently." | 1.62 | Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota. ( Chen, L; Han, R; Hong, Y; Li, B; Li, H; Ma, J; Qiu, H; Sheng, L; Wu, G; Zheng, N; Zhong, J, 2021) |
| "Allopurinol treatment significantly reduced hepatic steatosis, epididymal fat, serum UA, HOMA-IR, hepatic enzyme levels, and cholesterol in the OLETF-HFrD-Allo group." | 1.62 | Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. ( Ahn, KJ; Cho, IJ; Chung, HY; Hwang, YC; Jeong, IK; Jeong, SW; Lee, SH; Lim, SJ; Moon, JY; Oh, DH; Yoo, J, 2021) |
| "Gout is an inflammatory disease triggered by deposition of monosodium urate (MSU) crystals in the joints, resulting in high neutrophil influx and pain." | 1.62 | CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis. ( Galvão, I; Levi-Schaffer, F; Queiroz-Junior, CM; Teixeira, MM; Valiate, BVS, 2021) |
| "Comparative analysis with obesity, type 2 diabetes, ankylosing spondylitis and rheumatoid arthritis indicated that gout metagenomes were more similar to those of autoimmune than metabolic diseases." | 1.62 | Metagenomic analysis revealed the potential role of gut microbiome in gout. ( Bai, X; Chen, X; Chu, Y; Ding, F; Fang, X; Gao, Q; He, X; Huang, Q; Huang, R; Huang, Y; Jiang, Y; Li, J; Liang, L; Sun, S; Wang, M; Wang, P; Wang, Z; Wei, X; Wu, J; Wu, X; Xie, X; Yang, J; Yue, Z; Zhang, Y; Zhao, Y; Zhou, C, 2021) |
| "Rheumatoid arthritis is a chronic and systemic autoimmune disease, which affects approximately 1% of the adult population worldwide." | 1.56 | Theacrine alleviates chronic inflammation by enhancing TGF-β-mediated shifts via TGF-β/SMAD pathway in Freund's incomplete adjuvant-induced rats. ( Gao, M; Huang, Q; Huang, Z; Zheng, C; Zheng, J, 2020) |
| "Hyperuricemia is an important risk factor for many diseases including hypertension and type 2 diabetes." | 1.56 | Comparisons of protective effects between two sea cucumber hydrolysates against diet induced hyperuricemia and renal inflammation in mice. ( Bao, W; Han, J; Li, Y; Lu, C; Ming, T; Su, X; Tang, S; Wan, H; Zhou, J, 2020) |
| "The current treatment options for soft tissue injuries remain suboptimal and often result in delayed or incomplete recovery of damaged muscles." | 1.56 | Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury. ( Ho, CS; Hsu, YJ; Huang, CC; Kan, NW; Lee, MC, 2020) |
| "Twenty-four male Wistar-Kyoto rats (220-240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/kg/day Vit E or 200 mg/kg/day α-Lip." | 1.56 | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles. ( Abdelhalim, MAK; Al-Mohy, YH; Ghannam, MM; Qaid, HA, 2020) |
| "Acute gouty arthritis is an auto-inflammatory disease caused by the deposition of monosodium urate (MSU) crystals in joints or tissues." | 1.56 | 1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol (PLAG) Mitigates Monosodium Urate (MSU)-Induced Acute Gouty Inflammation in BALB/c Mice. ( Jeong, J; Kim, JH; Kim, JW; Shin, SH; Sohn, KY; Yoon, SY, 2020) |
| "Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, with oxidative stress and inflammation implicated in its development." | 1.56 | Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: Potential biomarkers in multicomponent models comprising IL-1beta. ( Čepelak, I; Hlapčić, I; Popović-Grle, S; Rako, I; Rogić, D; Rumora, L, 2020) |
| "Rhein has protective effect on uric acid nephropathy (UAN)." | 1.56 | Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis. ( Hu, J; Wang, D; Wu, H; Yang, Z, 2020) |
| "Gout is an inflammatory arthritis caused by the phagocytosis of monosodium urate (MSU) crystal deposition in joints." | 1.56 | EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. ( Chuang, JP; Kao, CY; Lee, JC; Leu, TH; Ling, P; Maa, MC, 2020) |
| "Gouty arthritis is the one of the most painful arthritis and is caused by an inflammatory reaction." | 1.56 | Astaxanthin attenuates joint inflammation induced by monosodium urate crystals. ( Ho, YJ; Hsieh, TH; Lee, CH; Lee, HS; Liu, FC; Lu, JW; Peng, YJ; Wang, CC; Wu, CC, 2020) |
| "Uric acid is a potential metabolite that serves as a danger-associated molecular pattern (DAMP) and induces inflammatory responses in sterile environments." | 1.56 | Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains. ( An, SJ; Choi, BK; Jun, HK; Kim, HY, 2020) |
| "Pain was determined using the electronic von Frey and static weight bearing." | 1.56 | IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis. ( Alves-Filho, JC; Amaral, FA; Casagrande, R; Cunha, FQ; Cunha, TM; Fattori, V; Louzada-Junior, P; Oliveira, RD; Staurengo-Ferrari, L; Teixeira, MM; Verri, WA; Zaninelli, TH, 2020) |
| "Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals." | 1.56 | HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF- ( Gao, W; Huang, Q; Liu, J; Long, F; Mu, H; Qin, T; Ren, L; Tang, H; Zeng, M, 2020) |
| "Uric acid has been reported to activate Nod-like receptor protein 3 (NLRP3)-inflammasome and alter vascular smooth muscle cells (VSMC)." | 1.51 | Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. ( Li, H; Liu, H; Qian, F; Zhang, Z, 2019) |
| "In contrast, Uox-KO mice with carotid atherosclerosis showed severe neointimal changes in histology staining consistent with increases in intimal area and increases in proliferating cell nuclear antigen (PCNA)- and F4/80-positive cells." | 1.51 | Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis. ( Ji, X; Li, C; Liu, Z; Lu, J; Merriman, TR; Qu, X; Sun, M; Wu, X; Yuan, X, 2019) |
| "Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases." | 1.51 | mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy? ( Broen, JCA; Jansen, M; Merriman, T; Ottria, A; Phipps-Green, A; Radstake, TRDJ; Schuiveling, M; van der Linden, M; van Lochem, E; Vazirpanah, N; Wichers, CGK; Zimmermann, M, 2019) |
| "Gout is one of the most common metabolic disorders in human." | 1.51 | Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation. ( Chen, J; Duan, L; Rao, X; Razavi, M; Tao, Y; Wei, Y; Zhong, J, 2019) |
| "Gout is the most common inflammatory arthritis affecting men." | 1.48 | Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. ( Ashimbayeva, E; Astin, JW; Britto, D; Crosier, KE; Crosier, PS; Dalbeth, N; Hall, CJ; Harper, JL; Lawrence, LM; Lieschke, GJ; Pool, B; Sanderson, LE; van der Kroef, M, 2018) |
| "Uric acid was shown to be one of the "danger" signals involved in the activation of NLRP3 inflammasome; notably, the concentration of uric acid is increased in the serum and in the cerebrospinal fluid of MS individuals." | 1.48 | Monosodium Urate Crystals Activate the Inflammasome in Primary Progressive Multiple Sclerosis. ( Caputo, D; Clerici, M; La Rosa, F; Marventano, I; Mendozzi, L; Piancone, F; Rovaris, M; Santangelo, MA; Saresella, M, 2018) |
| "Nicotine is an important factor in the pathogenesis of renal injury in smokers." | 1.48 | Renoprotective effect of Spirulina platensis extract against nicotine-induced oxidative stress-mediated inflammation in rats. ( Emam, MA; Zahran, WE, 2018) |
| "Hyperuricemia is an important risk factor for cardiovascular and renal diseases." | 1.46 | Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. ( Chen, Y; Cheng, J; Liu, J; Liu, S; Lu, Y; Yuan, Y; Zhao, M; Zhou, Y, 2017) |
| "Because inflammation has an important pathogenetic role in metabolic and cardiovascular disease, our study may help understanding the mechanism by which hyperuricemia may contribute to organ damage." | 1.46 | Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells. ( Andreozzi, F; Di Fatta, C; Fuoco, A; Mancuso, E; Mannino, GC; Marini, MA; Perticone, F; Sesti, G; Spiga, R, 2017) |
| "Uric acid plays an important role in CVD pathogenesis by inducing inflammatory COX-2 and ROS pathways." | 1.46 | Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells. ( Çetin, A; Kırça, M; Oğuz, N; Yeşilkaya, A, 2017) |
| "Uric acid has neuroprotective effect on Parkinson's disease (PD) by inhibiting oxidative damage and neuronal cell death." | 1.46 | Uric acid demonstrates neuroprotective effect on Parkinson's disease mice through Nrf2-ARE signaling pathway. ( Hao, DL; Huang, TT; Mao, LL; Wu, BN; Zhang, J, 2017) |
| "Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints." | 1.46 | Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. ( Amaral, FA; Galvão, I; Garcia, CC; Macia, LM; Mackay, CR; Martins, FS; Sernaglia, ÉM; Sousa, LP; Tavares, LP; Teixeira, MM; Vieira, AT; Vinolo, MA, 2017) |
| "Gout is a self-limited inflammatory disease caused by deposition of monosodium urate (MSU) crystals in the joints." | 1.46 | Annexin A1 promotes timely resolution of inflammation in murine gout. ( Amaral, FA; Barroso, LC; Carneiro, FS; Costa, VV; Ferreira, TP; Galvão, I; Queiroz-Junior, CM; Silva, PM; Sousa, LP; Tavares, LP; Teixeira, MM; Vago, JP, 2017) |
| "Gout is the most common inflammatory arthritis in adults in the Western world." | 1.43 | Gout: will the "King of Diseases" be the first rheumatic disease to be cured? ( Singh, JA, 2016) |
| "Gefitinib treatment also inhibited hyperuricemia-induced activation of the TGF-β1 and NF-κB signaling pathways and expression of multiple profibrogenic cytokines/chemokines in the kidney." | 1.42 | EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy. ( Bao, W; Cheng, SB; Chin, YE; Liu, N; Qiu, A; Shi, Y; Wang, L; Xiong, C; Xu, L; Yan, H; Yang, T; Zhuang, S, 2015) |
| "Metabolic syndrome was classified according to the Joint Interim Statement, and sleep duration was categorized as very short, short, adequate, and long sleepers (≤ 4, 5-6, 7-8, and ≥ 9 h per night, respectively)." | 1.42 | Contribution of Inflammation, Oxidative Stress, and Antioxidants to the Relationship between Sleep Duration and Cardiometabolic Health. ( Ardern, CI; Kanagasabai, T, 2015) |
| "Twenty-five ADPKD patients without hypertension and 25 healthy controls were studied cross-sectionally." | 1.40 | Pentraxin 3 as a novel bio-marker of inflammation and endothelial dysfunction in autosomal dominant polycystic kidney disease. ( Eroglu, E; Gungor, O; Imamoglu, H; Karakukcu, C; Kocyigit, I; Orscelik, O; Oymak, O; Ozturk, F; Sipahioglu, MH; Tokgoz, B; Unal, A, 2014) |
| "Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils in response to monosodium urate (MSU) crystals." | 1.40 | Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. ( Bilyy, R; Frey, B; Harrer, T; Herrmann, M; Hoffmann, M; Holmdahl, R; Janko, C; Jeremic, I; Kienhöfer, D; Krenn, V; Lell, M; Manger, B; Munoz, LE; Naschberger, E; Rech, J; Schauer, C; Schett, G; Zhao, Y, 2014) |
| "Gouty arthritis is caused by the precipitation of monosodium urate monohydrate (MSU) crystals in the joints." | 1.40 | Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice. ( Galli, SJ; Gaudenzio, N; Iwakura, Y; Karasuyama, H; Marichal, T; Reber, LL; Robinson, WH; Schwartz, LB; Sokolove, J; Starkl, P; Tsai, M, 2014) |
| "The bilirubin and UA levels were lower in CIS and RRMS patients than in control group, whether male or female (p < 0." | 1.39 | Association of serum bilirubin and uric acid levels changes during neuroinflammation in patients with initial and relapsed demyelination attacks. ( Dunjic, O; Ljubisavljevic, S; Milojkovic, M; Pavlovic, D; Stojanov, D; Stojanovic, I; Vojinovic, S, 2013) |
| "Gout is an ancient autoinflammatory disease that affects millions of people worldwide." | 1.39 | Transient receptor potential melastatin 2: a novel target for treatment of gout. ( Qiao, L; Zhai, Y; Zhong, Z, 2013) |
| "In conclusion, weight loss is effective in treating obese children with SDB." | 1.38 | Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid. ( Aerts, P; De Backer, WA; Debode, P; Desager, KN; Franckx, H; Ramet, J; Van Gaal, LF; Van Hoorenbeeck, K; Verhulst, SL; Wouters, K, 2012) |
| "Gout was induced by injecting MSU crystals into the joints of mice." | 1.38 | NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. ( Amaral, FA; Coelho, FM; Costa, VV; Cunha, FQ; Cunha, LD; Cunha, TM; Fagundes, CT; Peres, RS; Quesniaux, V; Ryffel, B; Sachs, D; Silveira, TN; Soriani, FM; Souza, DG; Tavares, LD; Teixeira, MM; Zamboni, DS, 2012) |
| "Acute gouty arthritis is a common inflammation model with multiple pathogenic mechanisms seen in clinical practice, for which acupuncture may potentially be an alternative therapy." | 1.37 | Effect of acupuncture on rats with acute gouty arthritis inflammation: a metabonomic method for profiling of both urine and plasma metabolic perturbation. ( Liu, YJ; Wen, SL; Xiao, J; Xue, JT; Ye, LM; Yin, HL; Zhang, L; Zhu, HY, 2011) |
| "Gout is increasing in prevalence throughout the world, particularly in developed countries." | 1.37 | Hyperuricaemia and gout. ( Shipley, M, 2011) |
| "CRP was significantly increased in the COPD patients with IC < 80% pred." | 1.37 | Dynamic pulmonary hyperinflation and low grade systemic inflammation in stable COPD patients. ( Aliprandi, G; Fredi, M; Gatta, D; Pini, L; Tantucci, C; Zanardini, A, 2011) |
| "Risk of cancer is increased in conditions associated with insulin resistance, but this could be secondary to subclinical inflammation." | 1.36 | Insulin resistance-related biomarker clustering and subclinical inflammation as predictors of cancer mortality during 21.5 years of follow-up. ( Godsland, IF; Johnston, DG; Loh, WJ; North, BV, 2010) |
| "Malnutrition and inflammation are common and serious complications in patients with acute kidney injury (AKI)." | 1.36 | Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome. ( Chen, XL; He, Q; Hong, DQ; Li, GS; Pu, L; Wang, F; Wang, L; Yang, XC; Zhang, P; Zhang, Y, 2010) |
| "Uric acid is a major hydrophilic acceptor of ROS; monoenic oleic fatty acid acts as its major lipophilic acceptor." | 1.36 | [Plasma antioxidant activity--a test for impaired biological functions of endoecology, exotrophy, and inflammation reactions]. ( Dmitriev, VA; Iashin, IaI; Krylin, VV; Titov, VN, 2010) |
| "Gout is the most common autoinflammatory arthritis characterized by elevated serum urate and recurrent attacks of intra-articular crystal deposition of monosodium urate (MSU)." | 1.35 | NALP3 inflammasome functional polymorphisms and gout susceptibility. ( Li, CG; Meng, DM; Mi, QS; Miao, ZM; Wang, YG; Yan, SL; Zhao, SH; Zhou, L, 2009) |
| "Hyperuricemia is common after kidney transplantation." | 1.35 | Association of uric acid with inflammation, progressive renal allograft dysfunction and post-transplant cardiovascular risk. ( Bandukwala, F; Huang, M; Nash, MM; Prasad, GV; Zaltzman, JS, 2009) |
| "Gout is an acute rheumatic disorder that occurs in connection with the deposition of monosodium urate (MSU) crystals in the joints." | 1.30 | Altered arachidonic acid metabolism in urate crystal induced inflammation. ( Duffin, KL; Gregory, SA; Isakson, PC; Margalit, A; Shaffer, AF, 1997) |
| "When histamine was injected into the joints, a marked increase in vascular permeability but no leukocytosis above control levels was observed." | 1.26 | Induction of arthritis by purified cell-derived chemotactic factor: role of chemotaxis and vascular permeability. ( Mandell, B; Rosenberg, D; Spilberg, I, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (10.34) | 18.7374 |
| 1990's | 26 (3.90) | 18.2507 |
| 2000's | 80 (11.99) | 29.6817 |
| 2010's | 284 (42.58) | 24.3611 |
| 2020's | 208 (31.18) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, T | 1 |
| Li, P | 4 |
| Zhou, X | 10 |
| Wang, R | 3 |
| Fan, X | 1 |
| Yang, M | 2 |
| Qi, K | 1 |
| Luo, LS | 1 |
| Wang, Y | 18 |
| Dai, LJ | 1 |
| He, FX | 1 |
| Zhang, JL | 1 |
| Zhou, Q | 2 |
| Goo, B | 1 |
| Lee, J | 1 |
| Park, C | 2 |
| Yune, T | 1 |
| Park, Y | 1 |
| Zhang, J | 10 |
| Lin, X | 3 |
| Xu, J | 2 |
| Tang, F | 2 |
| Tan, L | 1 |
| Zhou, GQ | 1 |
| Chen, G | 8 |
| Yang, J | 8 |
| Qin, WY | 2 |
| Ping, J | 1 |
| Wen, S | 1 |
| Arakawa, H | 1 |
| Tamai, I | 1 |
| Rhee, SJ | 1 |
| Lee, H | 4 |
| Ahn, YM | 1 |
| Pan, C | 1 |
| Chen, Y | 16 |
| Wang, S | 11 |
| Li, M | 3 |
| Qu, S | 1 |
| Lan, Z | 2 |
| Chen, L | 7 |
| Feng, J | 4 |
| Xie, Z | 1 |
| Liu, Z | 8 |
| Wang, F | 4 |
| Liu, P | 4 |
| Yue, X | 1 |
| Du, L | 3 |
| Zhao, Y | 7 |
| Yang, P | 2 |
| Luo, J | 2 |
| Zhu, Z | 2 |
| Hu, X | 2 |
| Cao, L | 5 |
| Lu, P | 1 |
| Sah, R | 1 |
| Lavine, K | 1 |
| Kim, B | 1 |
| Hu, H | 1 |
| Sung, YY | 1 |
| Kim, DS | 1 |
| Lin, Y | 4 |
| Xie, Y | 4 |
| Hao, Z | 1 |
| Bi, H | 1 |
| Liu, Y | 17 |
| Yang, X | 7 |
| Xia, Y | 3 |
| Zhuang, J | 2 |
| Liu, T | 3 |
| Zhang, S | 6 |
| Yuan, F | 1 |
| Zhang, L | 8 |
| Yang, Z | 4 |
| Guo, T | 2 |
| Yang, L | 1 |
| Ouyang, R | 1 |
| Zhao, X | 2 |
| Zhang, R | 1 |
| Li, S | 8 |
| Deng, D | 1 |
| Brien, ME | 1 |
| Hughes, K | 1 |
| Girard, S | 1 |
| Miller, AS | 1 |
| Hidalgo, TN | 1 |
| Abrahams, VM | 1 |
| Ye, C | 3 |
| Huang, X | 2 |
| Halimulati, M | 1 |
| Aihemaitijiang, S | 1 |
| Zhang, Z | 3 |
| Ebrahimi, R | 1 |
| Pasalar, P | 1 |
| Shokri, H | 1 |
| Shabani, M | 1 |
| Emamgholipour, S | 1 |
| Zhao, L | 6 |
| Zhao, T | 3 |
| Xu, R | 2 |
| Liu, J | 11 |
| Lin, C | 2 |
| Yu, Y | 4 |
| Xuan, D | 3 |
| Zhu, X | 4 |
| Liu, L | 10 |
| Hua, Y | 3 |
| Deng, C | 1 |
| Wan, W | 3 |
| Zou, H | 4 |
| Xue, Y | 8 |
| Al Shanableh, Y | 1 |
| Hussein, YY | 1 |
| Saidwali, AH | 1 |
| Al-Mohannadi, M | 1 |
| Aljalham, B | 1 |
| Nurulhoque, H | 1 |
| Robelah, F | 1 |
| Al-Mansoori, A | 1 |
| Zughaier, SM | 1 |
| Ballur, AFH | 1 |
| Altinoz, E | 1 |
| Yigitturk, G | 1 |
| Onal, MO | 1 |
| Elbe, H | 1 |
| Bicer, Y | 1 |
| Karayakali, M | 2 |
| Demir, M | 1 |
| Akhigbe, RE | 1 |
| Oladipo, AA | 1 |
| Oyedokun, PA | 1 |
| Hamed, MA | 1 |
| Okeleji, LO | 1 |
| Ajayi, AF | 1 |
| Chen, J | 12 |
| Mei, A | 1 |
| Liu, X | 9 |
| Braunstein, Z | 1 |
| Wei, Y | 5 |
| Wang, B | 3 |
| Duan, L | 2 |
| Rao, X | 2 |
| Rajagopalan, S | 1 |
| Dong, L | 2 |
| Zhong, J | 4 |
| Wang, H | 7 |
| Xie, L | 1 |
| Song, X | 2 |
| Wang, J | 7 |
| Li, X | 16 |
| Lin, Z | 3 |
| Su, T | 1 |
| Liang, B | 1 |
| Huang, D | 1 |
| Gnemmi, V | 1 |
| Li, Q | 3 |
| Ma, Q | 3 |
| De Chiara, L | 1 |
| Carangelo, G | 1 |
| Li, C | 6 |
| Molina-Van den Bosch, M | 1 |
| Romagnani, P | 2 |
| Anders, HJ | 4 |
| Steiger, S | 6 |
| Cobo, I | 1 |
| Cheng, A | 1 |
| Murillo-Saich, J | 1 |
| Coras, R | 2 |
| Torres, A | 1 |
| Abe, Y | 1 |
| Lana, AJ | 1 |
| Schlachetzki, J | 1 |
| Liu-Bryan, R | 9 |
| Terkeltaub, R | 13 |
| Sanchez-Lopez, E | 1 |
| Glass, CK | 1 |
| Guma, M | 2 |
| Shaker, ME | 1 |
| Immler, R | 1 |
| Pruenster, M | 1 |
| Sellmayr, M | 1 |
| von Brunn, A | 1 |
| von Brunn, B | 1 |
| Ehmann, R | 1 |
| Wölfel, R | 1 |
| Napoli, M | 1 |
| Böttcher, RT | 1 |
| Sperandio, M | 1 |
| Hilsabeck, TAU | 1 |
| Wilson, KA | 1 |
| Bose, N | 1 |
| Raftery, D | 1 |
| Beck, JN | 1 |
| Lang, S | 1 |
| Jin, K | 1 |
| Nelson, CS | 1 |
| Oron, T | 1 |
| Stoller, M | 1 |
| Promislow, D | 1 |
| Brem, RB | 1 |
| Kapahi, P | 1 |
| Longo, GZ | 1 |
| Ordaz, KD | 1 |
| da Silva, DCG | 1 |
| Hinnig, PF | 1 |
| Roberto, DMT | 1 |
| Reinert, C | 1 |
| Pot, GK | 1 |
| Palla, L | 1 |
| ALRashdi, BM | 1 |
| Elgebaly, HA | 1 |
| Germoush, MO | 1 |
| Qarmush, MM | 1 |
| Azab, MS | 1 |
| Alruhaimi, RS | 1 |
| Ahmeda, AF | 1 |
| Abukhalil, MH | 1 |
| Kamel, EM | 1 |
| Arab, HH | 1 |
| Alzoghaibi, MA | 1 |
| Alotaibi, MF | 1 |
| Mahmoud, AM | 1 |
| Chen, JS | 2 |
| Wang, MX | 3 |
| Wang, MM | 2 |
| Zhang, YK | 1 |
| Guo, X | 3 |
| Chen, YY | 1 |
| Zhang, MQ | 2 |
| Sun, JY | 3 |
| Liu, YF | 1 |
| Liu, C | 7 |
| Banik, SD | 1 |
| Avila-Nava, A | 1 |
| Lugo, R | 1 |
| Chim Aké, R | 1 |
| Gutiérrez Solis, AL | 1 |
| Riaz, M | 2 |
| Al Kury, LT | 1 |
| Atzaz, N | 1 |
| Alattar, A | 1 |
| Alshaman, R | 1 |
| Shah, FA | 1 |
| Wu, ZD | 1 |
| Yang, XK | 1 |
| He, YS | 1 |
| Ni, J | 1 |
| Yin, KJ | 1 |
| Huang, JX | 1 |
| Feng, YT | 1 |
| Wang, P | 4 |
| Pan, HF | 1 |
| Zamudio-Cuevas, Y | 3 |
| Martínez-López, V | 1 |
| Luján-Juárez, IA | 1 |
| Montaño-Armendariz, N | 1 |
| Martínez-Flores, K | 2 |
| Fernández-Torres, J | 2 |
| Gimeno, M | 1 |
| Sánchez-Sánchez, R | 1 |
| Natsuko, PD | 1 |
| Laura, SC | 1 |
| Denise, CC | 1 |
| Lucio, VR | 1 |
| Carlos, AS | 1 |
| Fausto, SM | 1 |
| Ambar, LM | 1 |
| Ye, W | 1 |
| Zhu, Y | 2 |
| Chen, F | 6 |
| Wang, Q | 6 |
| Lv, X | 1 |
| Du, Z | 1 |
| Liu, ZQ | 1 |
| Sun, X | 4 |
| Liu, ZB | 1 |
| Zhang, T | 6 |
| Zhang, LL | 1 |
| Wu, CJ | 1 |
| Kojima, S | 1 |
| Uchiyama, K | 1 |
| Yokota, N | 1 |
| Tokutake, E | 1 |
| Wakasa, Y | 1 |
| Hiramitsu, S | 1 |
| Waki, M | 1 |
| Jinnouchi, H | 1 |
| Kakuda, H | 1 |
| Hayashi, T | 1 |
| Kawai, N | 1 |
| Sugawara, M | 1 |
| Mori, H | 1 |
| Tsujita, K | 1 |
| Matsui, K | 1 |
| Hisatome, I | 4 |
| Ohya, Y | 1 |
| Kimura, K | 2 |
| Saito, Y | 1 |
| Ogawa, H | 1 |
| Piao, MH | 2 |
| Jiang, YJ | 1 |
| Wu, YL | 2 |
| Nan, JX | 2 |
| Lian, LH | 2 |
| Zaninelli, TH | 3 |
| Fattori, V | 3 |
| Saraiva-Santos, T | 1 |
| Badaro-Garcia, S | 2 |
| Staurengo-Ferrari, L | 3 |
| Andrade, KC | 2 |
| Artero, NA | 1 |
| Ferraz, CR | 1 |
| Bertozzi, MM | 1 |
| Rasquel-Oliveira, F | 1 |
| Manchope, MF | 1 |
| Amaral, FA | 11 |
| Teixeira, MM | 10 |
| Borghi, SM | 2 |
| Rogers, MS | 1 |
| Casagrande, R | 3 |
| Verri, WA | 3 |
| Kanagasabai, T | 2 |
| Riddell, MC | 1 |
| Ardern, CI | 2 |
| Cheng, JJ | 1 |
| Ma, XD | 1 |
| Ai, GX | 1 |
| Yu, QX | 1 |
| Chen, XY | 1 |
| Yan, F | 2 |
| Li, YC | 1 |
| Xie, JH | 1 |
| Su, ZR | 1 |
| Xie, QF | 1 |
| Hammer, HB | 1 |
| Rollefstad, S | 1 |
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| Rubilovitsch, M | 1 |
| Whitehouse, MW | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Comparative Trial on the Effect of Febuxostat in Preventing Cerebral and Cardiorenovascular Events in Patients With Hyperuricemia[NCT01984749] | 1,000 participants (Anticipated) | Interventional | 2013-11-30 | Active, not recruiting | |||
| Pilot Study on Safety and Performance of an Artificial Tear Containing Arabinogalactan, Trehalose and Hyaluronic Acid in the Treatment of Dry Eye in Subjects With Inflammation of the Ocular Surface[NCT04633863] | 24 participants (Actual) | Interventional | 2020-10-12 | Completed | |||
| Prospective Study of the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders[NCT06092346] | 999 participants (Anticipated) | Observational | 2024-01-03 | Recruiting | |||
| The Relationship Between Uric Acid and Inflammatory Markers[NCT01323335] | Phase 1 | 97 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia[NCT04420260] | 152 participants (Actual) | Interventional | 2021-03-18 | Completed | |||
| Assessing the Role of the NLRP3 Inflammasome in Driving Inflammation in Affected Joints of Patients With Intercritical Gout[NCT04125459] | 8 participants (Anticipated) | Observational | 2020-01-22 | Active, not recruiting | |||
| A Three Arms, Randomized, Double-blind Controlled Trial of the Efficacy of Amway Uric Acid Lowering Product on Hyperuricemia[NCT06084585] | 180 participants (Anticipated) | Interventional | 2023-10-23 | Recruiting | |||
| Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | ||
| Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept[NCT04012294] | Phase 3 | 200 participants (Anticipated) | Interventional | 2019-08-30 | Recruiting | ||
| Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)[NCT04358835] | 0 participants (Actual) | Interventional | 2020-09-01 | Withdrawn (stopped due to Study did not begin enrollment, multiple competing studies at same institution) | |||
| Compared Effect of a Fruit Milk Shake With a Protein-Carbohydrate Supplement on Muscle Damage, Inflammation, Oxidative Stress and Functional Recovery, After Resistance Exercise[NCT01555775] | 13 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among [NCT05170113] | 79 participants (Actual) | Interventional | 2021-11-02 | Completed | |||
| Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial[NCT04587544] | 76 participants (Actual) | Interventional | 2019-07-01 | Completed | |||
| Studies of Innate and Acquired Resistance to P. Falciparum Malaria in Mali[NCT00669084] | 1,718 participants (Actual) | Observational | 2008-04-21 | Completed | |||
| Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C[NCT01369043] | 1 participants (Actual) | Interventional | 2011-05-31 | Terminated (stopped due to Lack of successful recruiting, budget cuts, and potential study flaws.) | |||
| Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass[NCT00131040] | 24 participants | Interventional | 2003-01-31 | Completed | |||
| Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial[NCT00633581] | Phase 2/Phase 3 | 150 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| Effect of Low Dose of Colchicine on Platelet Reactivty in Patients With Chronic Coronary Disease[NCT05956145] | Phase 3 | 80 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| ACTH vs Betamethasone for the Treatment of Acute Gout in Hospitalized Patients: A Randomized, Open Label, Comparative Study[NCT04306653] | 60 participants (Anticipated) | Interventional | 2018-01-05 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
91 reviews available for uric acid and Inflammation
| Article | Year |
|---|---|
The contribution of sterile inflammation to the fatty liver disease and the potential therapies.
Topics: Adenosine Monophosphate; Alarmins; Caspase 1; Guanosine Monophosphate; Humans; Inflammation; Inflamm | 2022 |
Environmental factors and risk of gout.
Topics: Gout; Humans; Inflammation; Uric Acid | 2022 |
Excess Uric Acid Induces Gouty Nephropathy Through Crystal Formation: A Review of Recent Insights.
Topics: Endothelial Cells; Gout; Humans; Hyperuricemia; Inflammation; Renal Insufficiency, Chronic; Uric Aci | 2022 |
Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Topics: Arthritis, Gouty; Diet; Gout; Humans; Inflammation; Uric Acid | 2022 |
New markers in metabolic syndrome.
Topics: Adipokines; Alkaline Phosphatase; Biomarkers; Diabetes Mellitus, Type 2; Humans; Inflammation; Insul | 2022 |
Crystal arthropathies and osteoarthritis-where is the link?
Topics: Calcinosis; Crystal Arthropathies; Gout; Humans; Inflammation; Osteoarthritis; Uric Acid | 2023 |
Novel perception of neutrophil extracellular traps in gouty inflammation.
Topics: Extracellular Traps; Gout; Humans; Inflammation; Neutrophils; Perception; Uric Acid | 2023 |
A review on gout: Looking back and looking ahead.
Topics: Arthritis, Gouty; Extracellular Traps; Glucose Transport Proteins, Facilitative; Gout; Humans; Infla | 2023 |
Immune and inflammatory mechanisms and therapeutic targets of gout: An update.
Topics: Animals; Arthritis, Gouty; Cytokines; Gout; Inflammasomes; Inflammation; Macrophages; Uric Acid | 2023 |
The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications.
Topics: Arthritis, Gouty; Gout; Humans; Hyperuricemia; Inflammation; Uric Acid | 2023 |
Inflammation-The role of ATP in pre-eclampsia.
Topics: Adenosine Triphosphate; Female; Humans; Inflammation; Interleukin-1; Pre-Eclampsia; Pregnancy; Recep | 2020 |
Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia.
Topics: Animals; Arthritis, Gouty; Cellular Reprogramming; Epigenesis, Genetic; Humans; Hyperuricemia; Immun | 2020 |
[Vascular dysfunction in Cardiorenal Syndrome type 4].
Topics: Aorta; Arginine; Autonomic Nervous System Diseases; Bone Diseases, Metabolic; Cardio-Renal Syndrome; | 2020 |
Gout: Where Is the Weak Link?
Topics: Gout; Gout Suppressants; Humans; Inflammation; Uric Acid | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Advances in our understanding of gout as an auto-inflammatory disease.
Topics: Comorbidity; Gout; Humans; Hyperuricemia; Inflammation; Uric Acid | 2020 |
The Role of the Gut Microbiota in Coronary Heart Disease.
Topics: Animals; Cholesterol; Coronary Disease; Diabetes Complications; Dyslipidemias; Gastrointestinal Micr | 2020 |
The roles of NLRP3 inflammasome-mediated signaling pathways in hyperuricemic nephropathy.
Topics: Acute Kidney Injury; Animals; Cytokines; Diabetic Nephropathies; Humans; Hyperuricemia; Inflammasome | 2021 |
Uric acid participating in female reproductive disorders: a review.
Topics: Amniotic Fluid; Endometriosis; Female; Fetal Growth Retardation; Gonadal Steroid Hormones; Humans; I | 2021 |
Regulation of crystal induced inflammation: current understandings and clinical implications.
Topics: Gout; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Macrophages; Uric Acid | 2021 |
Fructose and the Liver.
Topics: Animals; Fructose; Humans; Inflammation; Liver; NLR Family, Pyrin Domain-Containing 3 Protein; Non-a | 2021 |
Could Sodium/Glucose Co-Transporter-2 Inhibitors Have Antiarrhythmic Potential in Atrial Fibrillation? Literature Review and Future Considerations.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Remodeling; Diabetes Mellitus, Type 2; Energy Me | 2021 |
Molecular Pathophysiology of Gout.
Topics: Animals; Arthritis, Gouty; Extracellular Traps; Granuloma; Humans; Inflammation; Uric Acid | 2017 |
What makes gouty inflammation so variable?
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Comorbidity; Forecasting; Humans; Inflammation; | 2017 |
Gout and Metabolic Syndrome: a Tangled Web.
Topics: Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Gout; Humans; Hyperlipide | 2017 |
Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis.
Topics: Animals; Atherosclerosis; Biomarkers; Cell Proliferation; Endoplasmic Reticulum Stress; Endothelium, | 2017 |
The Anticipated Renoprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors.
Topics: Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Fibrosis; Glucose; Humans; Hypoglycemic Agen | 2018 |
Sodium-glucose cotransporter 2 inhibitors and inflammation in chronic kidney disease: Possible molecular pathways.
Topics: Benzhydryl Compounds; Blood Pressure; Canagliflozin; Disease Progression; Glomerular Filtration Rate | 2018 |
The Role of Inhibitory Receptors in Monosodium Urate Crystal-Induced Inflammation.
Topics: Animals; Costimulatory and Inhibitory T-Cell Receptors; Disease Susceptibility; Gout; Humans; Immuno | 2018 |
Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes.
Topics: Alarmins; Animals; Calcium Phosphates; Cholesterol; Crystallization; Fatty Acids; Humans; Inflammaso | 2019 |
Can hyperuricemia predict glycogen storage disease (McArdle's disease) in rheumatology practice? (Myogenic hyperuricemia).
Topics: Adult; Antirheumatic Agents; Arthritis; Arthritis, Gouty; Diagnosis, Differential; Diagnostic Errors | 2019 |
Natural products for the management of hyperuricaemia and gout: a review.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Asteraceae; Biological Products; Double-Blind M | 2021 |
Chinese herbal medicine for gout: a systematic review of randomized clinical trials.
Topics: Drugs, Chinese Herbal; Gout; Humans; Inflammation; Medicine, Chinese Traditional; Pain Management; P | 2013 |
Mechanisms of spontaneous resolution of acute gouty inflammation.
Topics: Arthritis, Gouty; Cytokines; Gout; Humans; Inflammation; Joints; Macrophages; Neutrophils; Remission | 2014 |
Uric acid and xanthine oxidoreductase in wound healing.
Topics: Allopurinol; Chronic Disease; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Humans; Inf | 2014 |
A surprising role for uric acid: the inflammatory malaria response.
Topics: Animals; Erythrocytes; Host-Parasite Interactions; Humans; Inflammation; Inflammation Mediators; Mal | 2014 |
The role of uric acid in kidney fibrosis: experimental evidences for the causal relationship.
Topics: Animals; Disease Models, Animal; Fibrosis; Humans; Inflammation; Renal Insufficiency, Chronic; Uric | 2014 |
Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Colchicine; Gout; Gout Suppressants; Humans; Hype | 2014 |
Early diabetic nephropathy in type 1 diabetes: new insights.
Topics: Angiotensin II Type 2 Receptor Blockers; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease | 2014 |
[Pleiotropic effects of sevelamer: a model of intestinal tract chelating agent].
Topics: Animals; Bone Remodeling; Cardiovascular Diseases; Chelating Agents; Chelation Therapy; Disease Mode | 2014 |
Xanthine oxidoreductase in atherosclerosis pathogenesis: not only oxidative stress.
Topics: Adipocytes; Animals; Atherosclerosis; Cardiovascular Diseases; Cell Differentiation; Cell Movement; | 2014 |
Molecular basis of oxidative stress in gouty arthropathy.
Topics: Animals; Antioxidants; Arthritis, Gouty; Crystallization; Cytokines; Humans; Hyperuricemia; Immunity | 2015 |
The sterile inflammation in the exacerbation of HBV-associated liver injury.
Topics: Animals; Cytoplasm; Dendritic Cells; Heat-Shock Proteins; Hepatitis B virus; Hepatitis B, Chronic; H | 2015 |
Dispelling dogma and misconceptions regarding the most pharmacologically targetable source of reactive species in inflammatory disease, xanthine oxidoreductase.
Topics: Allopurinol; Animals; Humans; Inflammation; Nitric Oxide; Reactive Oxygen Species; Uric Acid; Xanthi | 2015 |
How neutrophil extracellular traps orchestrate the local immune response in gout.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Extracellular Traps; Gout; Humans; Inflam | 2015 |
Molecular mechanisms of pain in crystal-induced arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Calcium Pyrophosphate; Chondrocalc | 2015 |
Emerging Vascular Risk Factors in Women: Any Differences from Men?
Topics: Adult; Biomarkers; Female; Humans; Inflammation; Male; Periodontitis; Risk Factors; Sex Factors; Uri | 2015 |
Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: a multifactorial entity.
Topics: Acute Kidney Injury; Anemia; Biomarkers; Blood Glucose; Contrast Media; Hemodynamics; Hemoglobins; H | 2016 |
At the interface of antioxidant signalling and cellular function: Key polyphenol effects.
Topics: Animals; Antioxidants; Diet; Endothelial Cells; Endothelium, Vascular; Flavonoids; Humans; Inflammat | 2016 |
Hyperuricemia and Atrial Fibrillation.
Topics: Antioxidants; Atrial Fibrillation; Atrial Remodeling; Evidence-Based Medicine; Humans; Hyperuricemia | 2016 |
Pathogenesis and Clinical Management of Gouty Arthritis.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Gouty; Colchi | 2015 |
Factors modulating the inflammatory response in acute gouty arthritis.
Topics: Arthritis, Gouty; Autophagy; Gastrointestinal Microbiome; Gout; Humans; Hyperuricemia; Inflammasomes | 2017 |
Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.
Topics: Animals; Atherosclerosis; Disease Progression; Free Radicals; Heart Failure; Humans; Inflammasomes; | 2016 |
Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation.
Topics: Animals; Blood Pressure; Dietary Sugars; Fructose; Healthy Lifestyle; Humans; Hypertension; Hyperuri | 2017 |
Uric acid: A marker of increased cardiovascular risk.
Topics: Biomarkers; Cardiovascular Diseases; Carotid Artery Diseases; Coronary Artery Disease; Female; Heart | 2009 |
Systemic inflammation, metabolic syndrome and progressive renal disease.
Topics: C-Reactive Protein; Chemokine CCL2; Disease Progression; Fructose; Humans; Inflammation; Kidney Dise | 2009 |
The inflammasomes: guardians of the body.
Topics: Animals; Autoimmune Diseases; Carrier Proteins; Humans; Immunity, Innate; Inflammation; Interleukin- | 2009 |
[The relationship between damage associated molecular patterns, pathogen associated molecular patterns, alarmins and inflammatory response].
Topics: Heat-Shock Proteins; Hepatocyte Growth Factor; HMGB1 Protein; Humans; Inflammation; Interleukin-1alp | 2009 |
A clear and present danger: endogenous ligands of Toll-like receptors.
Topics: Apoptosis; Central Nervous System; Central Nervous System Diseases; Extracellular Matrix; Heat-Shock | 2010 |
Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome.
Topics: Animals; Arthritis, Gouty; Carrier Proteins; Humans; Immunity, Innate; Inflammation; Intracellular S | 2010 |
Update on biology: uric acid and the activation of immune and inflammatory cells.
Topics: Acute Disease; Crystallization; Gout; Humans; Immune System; Immunity, Innate; Inflammation; Inflamm | 2010 |
Mechanisms of inflammation in gout.
Topics: Acute Disease; Animals; Carrier Proteins; Chemotaxis, Leukocyte; Crystallization; Disease Models, An | 2010 |
The role of uric acid as an endogenous danger signal in immunity and inflammation.
Topics: Adjuvants, Immunologic; Animals; Autoimmunity; Carrier Proteins; Crystallization; Disease Models, An | 2011 |
[Role of uric acid in preeclampsia-eclampsia].
Topics: Animals; Causality; Cesarean Section; Eclampsia; Endothelium, Vascular; Female; Humans; Hypertension | 2011 |
Uric acid, hyperuricemia and vascular diseases.
Topics: Coronary Disease; Gout; Humans; Hypertension; Hyperuricemia; Inflammasomes; Inflammation; Metabolic | 2012 |
The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis).
Topics: Apoptosis; Arthritis, Gouty; Biomarkers; Calcium Phosphates; Carrier Proteins; Chondrocalcinosis; En | 2012 |
[The hyperiricosuria as an indicator of derangement of biologic functions of endoecology and adaptation, biologic reactions of excretion, inflammation and arterial tension].
Topics: Animals; Arterial Pressure; Glomerular Filtration Rate; Humans; Hyperuricemia; Inflammation; Kidney | 2012 |
Uric acid as a danger signal in gout and its comorbidities.
Topics: Biomarkers; Cardiovascular Diseases; Comorbidity; Crystallization; Diabetes Mellitus; Gout; Humans; | 2013 |
The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome.
Topics: Animals; Endothelium, Vascular; Humans; Hypertension; Hyperuricemia; Inflammation; Metabolic Syndrom | 2012 |
Hyperuricaemia: more than just a cause of gout?
Topics: Animals; Biomarkers; Cardiovascular Diseases; Female; Gout; Humans; Hyperuricemia; Inflammation; Kid | 2013 |
[Crystal-induced joint inflammation].
Topics: Acute Disease; Arthritis; Calcium; Calcium Pyrophosphate; Crystallization; Cytokines; Humans; Inflam | 2003 |
Pleural models of inflammation: immune and nonimmune.
Topics: Animals; Arthritis; Arthus Reaction; Calcium Pyrophosphate; Carrageenan; Cattle; Crystallization; Di | 2003 |
Pathogenesis of gout.
Topics: Cardiovascular Diseases; Crystallization; Diet; Gout; Humans; Hyperuricemia; Inflammation; Insulin R | 2005 |
Gout: update on some pathogenic and clinical aspects.
Topics: Crystallization; Gout; Humans; Inflammation; Joints; Magnetic Resonance Imaging; Uric Acid | 2006 |
The inflammatory process of gout and its treatment.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Clinical Trials | 2006 |
The inflammasome: first line of the immune response to cell stress.
Topics: Adenosine Triphosphate; Animals; Apoptosis Regulatory Proteins; Calcium Pyrophosphate; Calcium-Bindi | 2006 |
Recent advances in crystal-induced acute inflammation.
Topics: Acute Disease; Carrier Proteins; Gout; Humans; Immunity, Innate; Inflammation; Interleukin-1beta; Me | 2007 |
[The current opinion on inflammatory, biochemistry and hemostatic markers and factors in atherosclerosis. Part II].
Topics: Animals; Atherosclerosis; Biomarkers; Causality; Clinical Trials as Topic; Comorbidity; Fibrin Fibri | 2006 |
Recent developments in crystal-induced inflammation pathogenesis and management.
Topics: Chondrocalcinosis; Evidence-Based Medicine; Gout; Humans; Inflammation; Uric Acid | 2007 |
Altered uric acid levels and disease states.
Topics: Animals; Cardiovascular Diseases; Gout; Humans; Hypertension; Hyperuricemia; Inflammation; Kidney Di | 2008 |
The role of interleukin-1 and the inflammasome in gout: implications for therapy.
Topics: Animals; Arthritis, Gouty; Carrier Proteins; Colchicine; Gout; Gout Suppressants; Humans; Hyperurice | 2007 |
Update on gout: pathophysiology and potential treatments.
Topics: Animals; Cardiovascular Diseases; Gout; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Immu | 2007 |
Ischemic-reperfusion syndromes: biochemical and immunologic rationale for IL-1 targeted therapy.
Topics: Animals; Calcium Pyrophosphate; Carrier Proteins; Cytoskeletal Proteins; Humans; Inflammation; Inter | 2008 |
The biochemistry and pathophysiology of the contact system of plasma.
Topics: alpha 1-Antitrypsin; alpha-Macroglobulins; Animals; Antigen-Antibody Complex; Antithrombin III; Base | 1982 |
Molecular mechanisms of gouty arthritis: new insights into an old disease.
Topics: Arthritis; Blood Proteins; Gout; Humans; Inflammation; Neutrophils; Phagocytosis; Protein Binding; U | 1984 |
Gout, uric acid metabolism, and crystal-induced inflammation.
Topics: Aged; Child; Female; Gout; Humans; Infant; Inflammation; Male; Uric Acid | 1995 |
Hyperuricemia and gout.
Topics: Arthritis, Gouty; Child; Child, Preschool; Crystallization; Gout; Humans; Inflammation; Kidney Trans | 1994 |
Gout and other crystal arthropathies.
Topics: Aged; Arthritis, Gouty; Calcium Pyrophosphate; Chronic Disease; Crystallization; Female; Gout; Human | 1997 |
Gout and hyperuricemia.
Topics: Crystallization; Epidemiologic Methods; Forecasting; Gout; Humans; Inflammation; Kidney; Kidney Calc | 1997 |
New knowledge of the pathogenesis of gout.
Topics: Aging; Complement System Proteins; Crystallization; Endotoxins; Factor XII; Gout; Humans; Hydrogen-I | 1978 |
Crystal-induced inflammation of the joints.
Topics: Animals; Arthritis; Colchicine; Dogs; Gout; Humans; Inflammation; Leukocytes; Phagocytosis; Uric Aci | 1970 |
28 trials available for uric acid and Inflammation
| Article | Year |
|---|---|
C-reactive Protein Levels and Cardiovascular Outcomes After Febuxostat Treatment in Patients with Asymptomatic Hyperuricemia: Post-hoc Analysis of a Randomized Controlled Study.
Topics: Atherosclerosis; C-Reactive Protein; Febuxostat; Female; Humans; Hyperuricemia; Inflammation; Male; | 2023 |
Immersion in Water Between 20-30
Topics: Biomarkers; Gout; Humans; Immersion; Indonesia; Inflammasomes; Inflammation; Pain; Pain Management; | 2023 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults.
Topics: Adult; Aged; Anthocyanins; Anti-Inflammatory Agents; Biomarkers; Blood Glucose; Cholesterol, LDL; Cy | 2021 |
A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study.
Topics: Biomarkers; Double-Blind Method; Female; Gene Expression; Humans; Inflammation; Interleukin-6; Lipid | 2017 |
Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial.
Topics: Adult; Antioxidants; Athletic Performance; Bicycling; Biomarkers; Cacao; Catechin; Citrulline; Cross | 2017 |
High-Resistant Starch, Low-Protein Flour Intervention on Patients With Early Type 2 Diabetic Nephropathy: A Randomized Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Di | 2019 |
[Effect of Different Walking Number on Inflammation and Nutrition in Patients with Chronic Kidney Disease].
Topics: C-Reactive Protein; Humans; Inflammation; Interleukin-6; Lipids; Nutritional Status; Parathyroid Hor | 2019 |
The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes.
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Blood Glucose; Body Mass | 2014 |
The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy--5-year follow-up.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Atorvastatin; Cardiomyopathy, Dilated; Cytokines; Fem | 2013 |
Dawn of the most influential mechanism from the nightmare of slow coronary flow phenomenon: a randomized controlled study.
Topics: Biomarkers; Coronary Angiography; Endothelium, Vascular; Female; Humans; Inflammation; Male; Middle | 2013 |
Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement.
Topics: Aged; Allantoin; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Res | 2015 |
Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia.
Topics: Adult; Aged; Allopurinol; Asymptomatic Diseases; Biomarkers; Female; Humans; Hyperuricemia; Inflamma | 2015 |
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomark | 2008 |
Influence of aerobic exercise at high and moderate intensities on lipid peroxidation in untrained men.
Topics: Adult; Chromatography, High Pressure Liquid; Creatine Kinase; Exercise; Exercise Tolerance; Follow-U | 2008 |
Influence of tart cherry juice on indices of recovery following marathon running.
Topics: Adaptation, Physiological; Adult; Analysis of Variance; Anti-Inflammatory Agents; Antioxidants; Biom | 2010 |
Time of sampling is crucial for measurement of cell-free plasma DNA following acute aseptic inflammation induced by exercise.
Topics: Acute Disease; Asepsis; C-Reactive Protein; Cell-Free System; Creatine Kinase; DNA; Exercise; Humans | 2010 |
Changes in markers of inflammation, antioxidant capacity and oxidative stress in smokers following consumption of milk, and milk supplemented with fruit and vegetable extracts and vitamin C.
Topics: Adult; Animals; Antioxidants; Ascorbic Acid; Beverages; Biomarkers; Cross-Over Studies; Cytokines; D | 2012 |
Safety of intradermal injection of monosodium urate crystals as a vaccine carrier in volunteers.
Topics: Adjuvants, Immunologic; Adult; Crystallization; Female; Humans; Inflammation; Injections, Intraderma | 2011 |
Nutrition intervention to decrease symptoms in patients with advanced heart failure.
Topics: Biomarkers; Carotenoids; Diet, Sodium-Restricted; Dietary Supplements; Dinoprost; Fatty Acids, Omega | 2013 |
Effect of nutritional antioxidant supplementation on systemic and pulmonary antioxidant status, airway inflammation and lung function in heaves-affected horses.
Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Dietary Supplements; Dinoprost; Exercise Test; | 2002 |
Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners.
Topics: Adolescent; Adult; alpha-Tocopherol; Antioxidants; Ascorbic Acid; C-Reactive Protein; Dietary Supple | 2004 |
Short-term trial of etanercept in Behçet's disease: a double blind, placebo controlled study.
Topics: Adolescent; Adult; Behcet Syndrome; Double-Blind Method; Etanercept; Genital Diseases, Male; Humans; | 2005 |
Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population: the InCHIANTI study.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cross-Sectional Studie | 2005 |
Clinical response to non-steroidal anti-inflammatory drugs in urate-crystal induced inflammation: a simultaneous study of intersubject and intrasubject variability.
Topics: Adult; Aged; Analysis of Variance; Computer Simulation; Cross-Over Studies; Crystallization; Double- | 1994 |
Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses.
Topics: Adult; Antioxidants; Biopsy; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cell Count; Cross- | 1999 |
[Limitations of the isotopic evaluation of the effects of diftalone and indomethacin on inflammation induced with subcutaneous injection of microcrystals of monosodic urate].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Humans; Indomethacin; Inflammation | 1978 |
An experimental model of acute inflammation in man.
Topics: Adult; Aspirin; Clinical Trials as Topic; Colchicine; Humans; Inflammation; Knee Joint; Male; Methyl | 1966 |
549 other studies available for uric acid and Inflammation
| Article | Year |
|---|---|
The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3.
Topics: Animals; Caspase 1; Humans; Immune System Diseases; Inflammasomes; Inflammation; Interleukin-1beta; | 2021 |
Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity.
Topics: Agaricales; Animals; Gout; Hyperuricemia; Inflammation; Inonotus; Mice; Triterpenes; Uric Acid; Xant | 2022 |
Bee Venom Alleviated Edema and Pain in Monosodium Urate Crystals-Induced Gouty Arthritis in Rat by Inhibiting Inflammation.
Topics: Animals; Arthritis, Gouty; Bee Venoms; Disease Models, Animal; Edema; Humans; Inflammation; Male; Pa | 2021 |
CTRP3 protects against uric acid-induced endothelial injury by inhibiting inflammation and oxidase stress in rats.
Topics: Adipokines; Animals; Apoptosis; Endothelium, Vascular; Humans; Inflammation; Male; Oxidative Stress; | 2022 |
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Topics: Animals; Caspase 1; Disease Models, Animal; Drugs, Chinese Herbal; Gout; Inflammasomes; Inflammation | 2022 |
CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages.
Topics: ADP-ribosyl Cyclase 1; Animals; Crystallization; Female; Gene Expression Regulation; Gout; Humans; H | 2021 |
Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status.
Topics: Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Depression; Female; Humans; Inflamma | 2021 |
The study of routine laboratory factors in children with mycoplasma pneumoniae pneumonia: serum uric acid may have anti-inflammatory effect.
Topics: Biomarkers; Child, Preschool; Female; Humans; Inflammation; Male; Mycoplasma pneumoniae; Pneumonia, | 2021 |
Mechanosensitive TRPV4 is required for crystal-induced inflammation.
Topics: Adult; Animals; Arthralgia; Arthritis; Arthritis, Gouty; Crystal Arthropathies; Gout; Humans; Inflam | 2021 |
Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats.
Topics: Animals; Egg Shell; Humans; Hyperuricemia; Inflammation; Injections; Kidney; Kidney Function Tests; | 2021 |
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Topics: Antioxidants; Atherosclerosis; Carboxylic Ester Hydrolases; Cell Adhesion; Cell Line, Tumor; Cells, | 2021 |
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Topics: Animals; Antioxidants; Hyperuricemia; Hypoxanthine; Inflammation; Kidney; Male; Mice; Mice, Inbred I | 2021 |
Paeonol reduces IL-β production by inhibiting the activation of nucleotide oligomerization domain-like receptor protein-3 inflammasome and nuclear factor-κB in macrophages.
Topics: Acetophenones; Animals; Carrier Proteins; Caspase 1; Inflammasomes; Inflammation; Lipopolysaccharide | 2022 |
FGF21 attenuates high uric acid‑induced endoplasmic reticulum stress, inflammation and vascular endothelial cell dysfunction by activating Sirt1.
Topics: Antioxidants; Apoptosis; Endoplasmic Reticulum Stress; Endothelium, Vascular; Fibroblast Growth Fact | 2022 |
Prenatal administration of IL-1Ra attenuate the neurodevelopmental impacts following non-pathogenic inflammation during pregnancy.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; Fetal Development; Fetal Growth Re | 2021 |
Human fetal membrane IL-1β production in response to bacterial components is mediated by uric-acid induced NLRP3 inflammasome activation.
Topics: Caspase 1; Chorioamnionitis; Extraembryonic Membranes; Female; Humans; Inflammasomes; Inflammation; | 2022 |
Dietary Inflammatory Index and the Risk of Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents.
Topics: Adult; China; Cross-Sectional Studies; Diet; Diet, Healthy; Female; Humans; Hyperuricemia; Inflammat | 2021 |
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells.
Topics: Biomarkers; Endoplasmic Reticulum Stress; Humans; Hyperuricemia; Inflammation; Interleukin-6; Leukoc | 2022 |
IL-37 blocks gouty inflammation by shaping macrophages into a non-inflammatory phagocytic phenotype.
Topics: Animals; Arthritis, Gouty; Glycogen Synthase Kinase 3 beta; Gout; Humans; Inflammation; Interleukin- | 2022 |
Prevalence of asymptomatic hyperuricemia and its association with prediabetes, dyslipidemia and subclinical inflammation markers among young healthy adults in Qatar.
Topics: Adolescent; Adult; Biomarkers; Cross-Sectional Studies; Dyslipidemias; Female; Humans; Hyperuricemia | 2022 |
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Gout; Inflammation; Melatonin; Ox | 2022 |
Upregulation of Uric Acid Production and Caspase 3 Signalling Mediates Rohypnol-Induced Cardiorenal Damage.
Topics: Adenosine Triphosphatases; Animals; Caspase 3; Flunitrazepam; Inflammation; Insulin Resistance; Male | 2022 |
Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation.
Topics: Animals; Cell Movement; Disease Models, Animal; Gene Expression Regulation; Glucagon-Like Peptide-1 | 2022 |
Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Hepatocytes; Humans; Inflammation; Interferon-gamma; Ju | 2022 |
Asymptomatic Hyperuricemia Promotes Recovery from Ischemic Organ Injury by Modulating the Phenotype of Macrophages.
Topics: Acute Kidney Injury; Animals; Humans; Hyperuricemia; Inflammation; Ischemia; Macrophages; Mice; Phen | 2022 |
Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response.
Topics: Animals; Arthritis, Gouty; Inflammation; Lipopolysaccharides; Macrophages; Mice; Uric Acid | 2022 |
Soluble uric acid inhibits β2 integrin-mediated neutrophil recruitment in innate immunity.
Topics: Animals; CD18 Antigens; Humans; Immunity, Innate; Inflammation; Mice; Neutrophil Infiltration; Neutr | 2022 |
A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.
Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Genome-Wide Association Study; Gout; Humans; | 2022 |
Dietary patterns and cardiovascular risk factors among Brazilians: A population-based study in Viçosa, Minas Gerais.
Topics: Adult; Body Mass Index; Brazil; Cardiovascular Diseases; Catalase; Cholesterol; Cholesterol, HDL; Cr | 2022 |
A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
Topics: Animals; Catalase; Creatinine; Cytokines; Flavonoids; Hyperuricemia; Inflammation; Kidney; Molecular | 2022 |
Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.
Topics: Animals; Fibrosis; Hyperuricemia; Inflammation; Iridoids; Kidney Diseases; Mice; Molecular Docking S | 2022 |
Association Between Low-Grade Inflammation and Hyperuricemia in Adults With Metabolic Syndrome in Yucatán, México.
Topics: Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; H | 2022 |
Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt.
Topics: Allopurinol; Animals; Arthritis, Gouty; Cymenes; Hyperuricemia; Inflammation; Male; NF-kappa B; NLR | 2022 |
Anti-inflammatory and Antioxidant Effect of Poly-gallic Acid (PGAL) in an In Vitro Model of Synovitis Induced by Monosodium Urate Crystals.
Topics: Anti-Inflammatory Agents; Antioxidants; Gallic Acid; Gout; Humans; Inflammation; Polyglutamic Acid; | 2022 |
Differential gene expression of ABCG2, SLC22A12, IL-1β, and ALPK1 in peripheral blood leukocytes of primary gout patients with hyperuricemia and their comorbidities: a case-control study.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Case-Control Studies; Gene Expression; Gout | 2022 |
Distinct macrophage polarization in acute and chronic gout.
Topics: Animals; Arginase; Gout; Humans; Inflammation; Macrophages; Mice; Nitric Oxide Synthase Type II; RNA | 2022 |
Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity.
Topics: Gastrointestinal Microbiome; Gout; Humans; Hyperuricemia; Inflammation; Lipopolysaccharides; Medicin | 2022 |
Natural Adrenocorticotropic Hormone (ACTH) Relieves Acute Inflammation in Gout Patients by Changing the Function of Macrophages.
Topics: Adrenocorticotropic Hormone; Animals; Arthritis, Gouty; Dexamethasone; Gout; Humans; Hydrocortisone; | 2022 |
Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy.
Topics: Arthritis, Gouty; Autophagy; Gout; Humans; Inflammation; Interleukin-1beta; Phagocytosis; Quercetin; | 2022 |
RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Calcitonin Gene-Related Peptide; Docosahexaenoic Acids; Hyperalgesia; Inf | 2022 |
Inflammation, Oxidative Stress, and Antioxidant Micronutrients as Mediators of the Relationship Between Sleep, Insulin Sensitivity, and Glycosylated Hemoglobin.
Topics: Antioxidants; Bilirubin; C-Reactive Protein; Carotenoids; Diabetes Mellitus; Glycated Hemoglobin; Hu | 2022 |
Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways.
Topics: Animals; Antioxidants; Arthritis, Gouty; Berberine Alkaloids; Cytokines; Inflammation; Interleukin-1 | 2022 |
Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study.
Topics: Adult; Aged; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Cross-Sectional Studies; | 2022 |
A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress.
Topics: Animals; Inflammation; Iridoids; Kelch-Like ECH-Associated Protein 1; Mice; NF-E2-Related Factor 2; | 2022 |
Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes.
Topics: Adipocytes; Allopurinol; Colchicine; Enzyme Inhibitors; Fatty Acids, Nonesterified; Febuxostat; Gout | 2022 |
Protective effects of di-caffeoylquinic acids from Artemisia selengensis Turcz leaves against monosodium urate-induced inflammation via the modulation of NLRP3 inflammasome and Nrf2 signaling pathway in THP-1 macrophages.
Topics: Artemisia; Gout; Inflammasomes; Inflammation; Interleukin-1beta; Macrophages; NF-E2-Related Factor 2 | 2022 |
Ultrasonography in the prediction of gout flares: a 12-month prospective observational study.
Topics: Gout; Humans; Inflammation; Prospective Studies; Symptom Flare Up; Ultrasonography; Uric Acid | 2023 |
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Topics: Allopurinol; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Colchicine; Creatinin | 2022 |
Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway.
Topics: Animals; Fibrosis; Hyperuricemia; Inflammation; Kidney; Mice; NF-kappa B; Phosphatidylinositol 3-Kin | 2022 |
Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF-κB and p62-Keap1 pathways.
Topics: Animals; Arthritis, Gouty; Caspase 1; Disease Models, Animal; DNA-Binding Proteins; Inflammasomes; I | 2022 |
Pueraria montana (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Body Weight; Creatinine; Cyclooxygenase 2; Diethylnitrosam | 2022 |
Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment.
Topics: Arthritis, Gouty; Collagen Type II; Cytokines; Gout; Humans; Inflammation; Matrilin Proteins; Uric A | 2023 |
Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency.
Topics: Animals; Fibrosis; Hyperuricemia; Inflammation; Kidney; Kidney Diseases; Nephrectomy; Oxonic Acid; R | 2023 |
Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation.
Topics: Adenine; Adenosine Triphosphate; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Caspase 1 | 2022 |
Anti-Hyperuricemic, Nephroprotective, and Gut Microbiota Regulative Effects of Separated Hydrolysate of α-Lactalbumin on Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.
Topics: Animals; Gastrointestinal Microbiome; Hyperuricemia; Hypoxanthines; Inflammation; Kidney; Lactalbumi | 2023 |
Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway.
Topics: Animals; Arthritis, Gouty; Inflammasomes; Inflammation; Interleukin-1beta; Mice; Myeloid Differentia | 2022 |
Live and pasteurized
Topics: Animals; Gastrointestinal Microbiome; Hyperuricemia; Inflammation; Mice; RNA, Messenger; Uric Acid; | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway.
Topics: Acute Kidney Injury; Animals; Hyperuricemia; Inflammation; Mice; Oxidative Stress; Phosphatidylinosi | 2022 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Topics: alpha-Tocopherol; Animals; Histone Deacetylase 6; Humans; Inflammasomes; Inflammation; Lysosomes; Mi | 2023 |
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Topics: Animals; Arthritis, Gouty; Cathepsin G; Female; Gout; Humans; Hyperuricemia; Inflammation; Interleuk | 2023 |
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Topics: Animals; Arthritis, Gouty; Cathepsin G; Female; Gout; Humans; Hyperuricemia; Inflammation; Interleuk | 2023 |
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Topics: Animals; Arthritis, Gouty; Cathepsin G; Female; Gout; Humans; Hyperuricemia; Inflammation; Interleuk | 2023 |
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Topics: Animals; Arthritis, Gouty; Cathepsin G; Female; Gout; Humans; Hyperuricemia; Inflammation; Interleuk | 2023 |
LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
Topics: Arthritis, Gouty; Cell Cycle Proteins; Humans; Inflammation; MicroRNAs; Nuclear Proteins; RNA, Long | 2023 |
LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
Topics: Arthritis, Gouty; Cell Cycle Proteins; Humans; Inflammation; MicroRNAs; Nuclear Proteins; RNA, Long | 2023 |
LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
Topics: Arthritis, Gouty; Cell Cycle Proteins; Humans; Inflammation; MicroRNAs; Nuclear Proteins; RNA, Long | 2023 |
LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
Topics: Arthritis, Gouty; Cell Cycle Proteins; Humans; Inflammation; MicroRNAs; Nuclear Proteins; RNA, Long | 2023 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation.
Topics: Animals; Carrier Proteins; Fish Proteins; Hyperuricemia; Inflammation; Intestinal Diseases; Kidney; | 2023 |
Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence.
Topics: Animals; Gout; Humans; Inflammation; Urate Oxidase; Uric Acid; Zebrafish | 2022 |
Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.
Topics: Animals; Gout; Inflammasomes; Inflammation; Macrophages; NF-E2-Related Factor 2; NLR Family, Pyrin D | 2022 |
Neutrophil Extracellular Trap-Borne Elastase Prevents Inflammatory Relapse in Intercritical Gout.
Topics: Animals; Chronic Disease; Extracellular Traps; Gout; Inflammation; Leukocyte Elastase; Mice; Uric Ac | 2023 |
Rutin ameliorates gout via reducing XOD activity, inhibiting ROS production and NLRP3 inflammasome activation in quail.
Topics: Animals; Gout; Inflammasomes; Inflammation; NLR Family, Pyrin Domain-Containing 3 Protein; Quail; Re | 2023 |
Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort.
Topics: Biological Specimen Banks; Biomarkers; Genome-Wide Association Study; Gout; Humans; Hyperuricemia; I | 2022 |
HDAC Inhibitors Alleviate Uric Acid-Induced Vascular Endothelial Cell Injury by Way of the HDAC6/FGF21/PI3K/AKT Pathway.
Topics: Animals; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Human Umbilical Vein Endothelial Cel | 2023 |
Biomineralized Nanoscavenger Abrogates Proinflammatory Macrophage Polarization and Induces Neutrophil Clearance through Reverse Migration during Gouty Arthritis.
Topics: Animals; Arthritis, Gouty; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Inflammation; Macrop | 2023 |
Relief effects of Laoshan cherry extracts as a dietary supplement against the symptoms of acute gouty arthritis in rats induced by urate crystals.
Topics: Animals; Antioxidants; Arthritis, Gouty; Dietary Supplements; Inflammation; Rats; Uric Acid | 2023 |
Topics: Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione; Inflammation; Mice; Mi | 2023 |
Serum uric acid variation and the risk of cardiovascular disease: A prospective cohort study.
Topics: Aged; Bayes Theorem; Biomarkers; Cardiovascular Diseases; Humans; Inflammation; Prospective Studies; | 2023 |
Urinary levels of kidney injury molecule-1 (KIM-1) and interleukin-18 (IL-18) in children and adolescents with hyperuricemia.
Topics: Adolescent; Adult; Biomarkers; Child; Female; Hepatitis A Virus Cellular Receptor 1; Humans; Hyperur | 2023 |
Scleroderma-like Disease Due to Diffuse Monosodium Urate Crystal Deposition.
Topics: Gout; Humans; Inflammation; Uric Acid | 2023 |
Diallyl trisulfide inhibits monosodium urate-induced NLRP3 inflammasome activation via NOX3/4-dependent mitochondrial oxidative stress in RAW 264.7 and bone marrow-derived macrophages.
Topics: Gout; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Macrophages; NLR Family, Pyrin Domain- | 2023 |
Correlation of serum omentin-1 level with clinical features and major adverse cardiac and cerebral events in patients undergoing continuous ambulatory peritoneal dialysis.
Topics: C-Reactive Protein; Cholesterol; Humans; Inflammation; Kidney Failure, Chronic; Peritoneal Dialysis, | 2023 |
Nickel exposure induces gut microbiome disorder and serum uric acid elevation.
Topics: Animals; Chromatography, Liquid; Gastrointestinal Microbiome; Humans; Inflammation; Mice; Nickel; Ta | 2023 |
Lead exposure induced developmental nephrotoxicity in Japanese quail (Coturnix japonica) via oxidative stress-based PI3K/AKT pathway inhibition and NF-κB pathway activation.
Topics: Animals; Coturnix; Inflammation; Lead; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinase; | 2023 |
Wuling San Based on Network Pharmacology and in vivo Evidence Against Hyperuricemia via Improving Oxidative Stress and Inhibiting Inflammation.
Topics: Animals; Drugs, Chinese Herbal; Hyperuricemia; Inflammation; Molecular Docking Simulation; Network P | 2023 |
Systemic immune-inflammation index may predict the acute kidney injury and prognosis in patients with spontaneous cerebral hemorrhage undergoing craniotomy: a single-center retrospective study.
Topics: Acute Kidney Injury; Cerebral Hemorrhage; Humans; Inflammation; Prognosis; Retrospective Studies; Ur | 2023 |
Glycine protects against doxorubicin-induced heart toxicity in mice.
Topics: Animals; Antioxidants; Cardiomyopathies; Cardiotoxicity; Catalase; Doxorubicin; Glutathione; Inflamm | 2023 |
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Topics: Animals; Hyperuricemia; Inflammation; Mice; Molecular Docking Simulation; NF-kappa B; Phosphatidylin | 2023 |
The predictive value of temporal muscle thickness measured by ultrasonography for detecting moderate to severe malnutrition in chronic hemodialysis patients.
Topics: Adult; Aged; Body Weight; Cross-Sectional Studies; Female; Humans; Inflammation; Male; Malnutrition; | 2023 |
Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies.
Topics: Arthritis, Gouty; Humans; Inflammation; Lipids; Metabolomics; Phospholipases A2; Proteomics; Uric Ac | 2023 |
Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.
Topics: Animals; Creatinine; Hyperuricemia; Inflammasomes; Inflammation; Interleukin-10; Interleukin-6; Janu | 2023 |
The Relationship between Uric Acid/Albumin Ratio and Carotid Intima-Media Thickness in Patients with Hypertension.
Topics: Atherosclerosis; C-Reactive Protein; Carotid Intima-Media Thickness; Humans; Hypertension; Inflammat | 2023 |
Predictive Ability of Serum Uric Acid Levels in Assessing the Severity of Chronic Liver Disease.
Topics: Adolescent; Adult; Child; Cross-Sectional Studies; Female; Humans; Inflammation; Liver Diseases; Mal | 2023 |
Renal herb formula protects against hyperuricemic nephropathy by inhibiting apoptosis and inflammation.
Topics: Animals; Apoptosis; Chlorogenic Acid; Creatinine; Hyperuricemia; Inflammation; Kidney; Kidney Diseas | 2023 |
A wild rice-derived peptide R14 ameliorates monosodium urate crystals-induced IL-1β secretion through inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Topics: Gout; Humans; Inflammasomes; Inflammation; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein | 2023 |
Polydatin ameliorates inflammation and oxidative stress associated with MSU-induced gouty arthritis in mice by regulating PPAR-γ and ferritin activation.
Topics: Animals; Arthritis, Gouty; Cytokines; Gout; Humans; Inflammasomes; Inflammation; Mice; Mice, Inbred | 2023 |
Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway.
Topics: Flavonoids; Humans; Hyperuricemia; Inflammation; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-O | 2023 |
Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome.
Topics: Allopurinol; Animals; Caspases; China; Epithelial Cells; Humans; Hyperuricemia; Inflammasomes; Infla | 2023 |
The correlation between dietary inflammatory index and risk of hyperuricemia in the U.S. population.
Topics: Adult; Diet; Female; Humans; Hyperuricemia; Inflammation; Logistic Models; Male; Nutrition Surveys; | 2023 |
M2 Macrophage Hybrid Membrane-Camouflaged Targeted Biomimetic Nanosomes to Reprogram Inflammatory Microenvironment for Enhanced Enzyme-Thermo-Immunotherapy.
Topics: Animals; Anti-Inflammatory Agents; Biomimetics; Cytokines; Erythrocyte Membrane; Immunotherapy; Infl | 2023 |
Clec12a inhibits MSU-induced immune activation through lipid raft expulsion.
Topics: Gout; Humans; Immunity, Innate; Inflammation; Lipids; Uric Acid | 2023 |
Gut microbiota mediated the therapeutic efficiency of Simiao decoction in the treatment of gout arthritis mice.
Topics: Allopurinol; Animals; Arthritis, Gouty; Gastrointestinal Microbiome; Inflammation; Mice; Uric Acid | 2023 |
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction.
Topics: Animals; Eurycoma; Hyperuricemia; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Uric Acid | 2023 |
Targeted treatment of gouty arthritis by biomineralized metallic nanozyme-mediated oxidative stress-mitigating nanotherapy.
Topics: Arthritis, Gouty; Humans; Inflammation; Oxidative Stress; Reactive Oxygen Species; Uric Acid | 2023 |
Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression.
Topics: Animals; Gout; Inflammation; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Sirtuin 3; Uric Acid | 2023 |
Identification of tophi in ultrasound imaging based on transfer learning and clinical practice.
Topics: Arthritis, Gouty; Gout; Humans; Inflammation; Machine Learning; Reproducibility of Results; Tomograp | 2023 |
MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Cyclooxygenase 2; Humans; Inflammasomes; Inflam | 2023 |
Comparison of the different monosodium urate crystals in the preparation process and pro-inflammation.
Topics: Animals; Gout; Humans; Inflammation; Interleukin-18; Tumor Necrosis Factor-alpha; Uric Acid | 2023 |
Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance.
Topics: Case-Control Studies; Child; Diabetes Mellitus, Type 2; Humans; Inflammasomes; Inflammation; Insulin | 2023 |
Serum uric acid to high-density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large-scale study.
Topics: Cohort Studies; Cross-Sectional Studies; Humans; Inflammation; Lipoproteins, HDL; Metabolic Syndrome | 2023 |
MSU crystal deposition contributes to inflammation and immune responses in gout remission.
Topics: Chronic Disease; Gout; Humans; Inflammation; Leukocytes, Mononuclear; Monocytes; Uric Acid | 2023 |
Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice.
Topics: Albumins; Animals; Chromatography, Liquid; Fibrosis; Hyperuricemia; Inflammasomes; Inflammation; Int | 2024 |
Neutrophil autophagy induced by monosodium urate crystals facilitates neutrophil extracellular traps formation and inflammation remission in gouty arthritis.
Topics: Animals; Arthritis, Gouty; Extracellular Traps; Inflammation; Mice; Neutrophils; Uric Acid | 2023 |
Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio.
Topics: Calcium; Humans; Inflammation; Kidney Calculi; Lymphocytes; Neutrophils; Renal Insufficiency, Chroni | 2023 |
Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model.
Topics: Animals; Arthritis, Gouty; Edema; Humans; Inflammation; Male; Pain; Rats; Rats, Wistar; Uric Acid | 2023 |
Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression.
Topics: Animals; Inflammation; Kelch-Like ECH-Associated Protein 1; Mice; NF-E2-Related Factor 2; Peritoniti | 2023 |
Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout.
Topics: Acute Disease; Animals; Arthritis, Gouty; Caspase 1; Cell Adhesion; Cell Movement; Class Ib Phosphat | 2019 |
Antihyperuricemic and anti-gouty arthritis activities of
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Carbon; Drugs, Chinese Herbal; Hyperuricemia; I | 2019 |
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
Topics: A549 Cells; Animals; Antibodies, Blocking; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, | 2019 |
Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system.
Topics: Animals; Antioxidants; Fibroblasts; Gout; Humans; Inflammation; Lactones; Male; MAP Kinase Kinase Ki | 2021 |
MSU crystals at-TAK!
Topics: Gout; Humans; Inflammation; MAP Kinase Kinase Kinases; Proteasome Endopeptidase Complex; Ubiquitin; | 2019 |
Inflammatory markers of contrast-induced nephropathy in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Acute Kidney Injury; Aged; C-Reactive Protein; Contrast Media; Coronary Ang | 2020 |
MSU Crystals induce sterile IL-1β secretion via P2X7 receptor activation and HMGB1 release.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Edema; HMGB1 Protein; Humans; Inflammation; | 2020 |
Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism.
Topics: Actins; Animals; Cardiovascular Diseases; Carrier Proteins; Cell Line; Cell Proliferation; China; Hu | 2019 |
MiR-146a alleviates inflammation of acute gouty arthritis rats through TLR4/MyD88 signal transduction pathway.
Topics: Animals; Ankle Joint; Arthritis, Gouty; Inflammation; Inflammation Mediators; Male; MicroRNAs; Myelo | 2019 |
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
Topics: Animals; Cell Line; Cytokines; Fibrosis; Humans; Hyperuricemia; Inflammasomes; Inflammation; Kidney | 2020 |
Theacrine alleviates chronic inflammation by enhancing TGF-β-mediated shifts via TGF-β/SMAD pathway in Freund's incomplete adjuvant-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chronic Disease; | 2020 |
PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis.
Topics: Animals; Biomarkers; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; | 2020 |
Comparisons of protective effects between two sea cucumber hydrolysates against diet induced hyperuricemia and renal inflammation in mice.
Topics: Animals; Cytokines; Hyperuricemia; Inflammation; Kidney; Male; Mice; Mice, Inbred ICR; Myeloid Diffe | 2020 |
Serum Uric Acid Shows Inverted "U" Type Correlation with Osteoporosis in Chinese Ankylosing Spondylitis Patients: A Retrospective Study.
Topics: Adolescent; Adult; Antirheumatic Agents; Asian People; Blood Platelets; Blood Sedimentation; Bone De | 2019 |
Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis.
Topics: Animals; Eucalyptol; Gout; Humans; Inflammation; Macrophages; Mice; Pain; Quality of Life; Uric Acid | 2020 |
Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation.
Topics: Adult; Arthritis, Gouty; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infla | 2019 |
Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Contusions; Creatine Kinase; Creatin | 2020 |
Association Between Electronic Cigarette Use and Levels of High-Sensitivity C-Reactive Protein and Uric Acid.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Humans; Inflammation; Male; Middle Aged; Nutrition Surv | 2020 |
Serum uric acid may modulate the inflammatory response after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction.
Topics: Aged; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Inflammation Mediators; Interleu | 2020 |
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.
Topics: Adult; AMP-Activated Protein Kinases; Animals; Atherosclerosis; Benzbromarone; Biomarkers; Disease M | 2020 |
Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo.
Topics: Adult; Animals; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; CARD Signaling Adaptor Prot | 2020 |
The protective effect of uric acid in reducing TLR4/NF-κB activation through the inhibition of HMGB1 acetylation in a model of ischemia-reperfusion injury in vitro.
Topics: Acetylation; Animals; Apoptosis; Cell Line; Gene Expression Regulation; HMGB1 Protein; Inflammation; | 2020 |
The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles.
Topics: Animals; Biomarkers; Creatinine; Glutathione; Gold; Inflammation; Kidney; Lipid Peroxidation; Male; | 2020 |
A mouse model of MSU-induced acute inflammation
Topics: Acute Disease; Adjuvants, Immunologic; Administration, Topical; Animals; Antioxidants; Cytokines; Di | 2020 |
The effect of reducing systemic inflammation on serum urate.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Sedimentation; C-Rea | 2020 |
Total saponin of Dioscorea collettii attenuates MSU crystal‑induced inflammation via inhibiting the activation of the NALP3 inflammasome and caspase‑1 in THP‑1 macrophages.
Topics: Arthritis, Gouty; Caspase 1; Cytokines; Dioscorea; Drugs, Chinese Herbal; Gene Expression Regulation | 2020 |
CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout.
Topics: Animals; Arthritis, Gouty; Cell Line; Cells, Cultured; Crystallization; Disease Models, Animal; Huma | 2020 |
Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1.
Topics: Adolescent; Adult; Cells, Cultured; CX3C Chemokine Receptor 1; Escherichia coli; Humans; Inflammatio | 2020 |
Arabinogalactan and hyaluronic acid in ophthalmic solution: Experimental effect on xanthine oxidoreductase complex as key player in ocular inflammation (in vitro study).
Topics: Drug Synergism; Galactans; Hyaluronic Acid; Inflammation; Ophthalmic Solutions; Reactive Oxygen Spec | 2020 |
1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol (PLAG) Mitigates Monosodium Urate (MSU)-Induced Acute Gouty Inflammation in BALB/c Mice.
Topics: Acute Disease; Animals; Arthritis, Gouty; Cell Movement; Diglycerides; Disease Models, Animal; Human | 2020 |
A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents.
Topics: Adolescent; Biomarkers; Blood Pressure; Cytokines; Diabetes Mellitus, Type 1; Female; Genotype; Gluc | 2020 |
Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: Potential biomarkers in multicomponent models comprising IL-1beta.
Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Creatinine; Cytokines; Female; Fibrinogen; | 2020 |
Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Proliferation; Cycloox | 2020 |
EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages.
Topics: Adaptor Proteins, Signal Transducing; Animals; Caspase 1; Enzyme Activation; Gout; Inflammasomes; In | 2020 |
Markers involved in proinflammatory effects by environmental toxicants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers; Blood Glucose; Environmental Pollutants; Fema | 2020 |
Systemic Investigation of Promoter-wide Methylome and Genome Variations in Gout.
Topics: Adult; Aged; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Gout; Humans; Hyp | 2020 |
Astaxanthin attenuates joint inflammation induced by monosodium urate crystals.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Cells, Cultured; Chondrocytes; Cyclooxygenase 2 | 2020 |
Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1β Production Through Monosodium Urate-Induced Mitochondrial DNA.
Topics: Animals; DNA Fragmentation; DNA, Mitochondrial; Inflammasomes; Inflammation; Interleukin-1beta; Macr | 2020 |
Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study.
Topics: Animals; Arthritis, Gouty; Diosgenin; Humans; Inflammasomes; Inflammation; Male; Mice; NLR Family, P | 2021 |
Cyr61 Promotes Inflammation of a Gouty Arthritis Model in Rats.
Topics: Animals; Arthritis, Gouty; Blotting, Western; Cysteine-Rich Protein 61; Cytokines; Fluorescent Antib | 2020 |
Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains.
Topics: Cell Line; Cytokines; Gingipain Cysteine Endopeptidases; Humans; Inflammation; Keratinocytes; Porphy | 2020 |
IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis.
Topics: Animals; Arthritis, Gouty; Female; Humans; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Inte | 2020 |
Serum urate is related to subclinical inflammation in asymptomatic hyperuricaemia.
Topics: C-Reactive Protein; Female; Humans; Hyperuricemia; Inflammation; Interleukin-6; Leukocytes, Mononucl | 2021 |
Estimate of prevalent hyperuricemia by systemic inflammation response index: results from a rural Chinese population.
Topics: Biomarkers; Cardiometabolic Risk Factors; China; Cross-Sectional Studies; Female; Humans; Hyperurice | 2021 |
Biliverdin and bilirubin sulfonate inhibit monosodium urate induced sterile inflammation in the rat.
Topics: Animals; Bilirubin; Biliverdine; Inflammation; Rats; Rats, Wistar; Uric Acid | 2020 |
Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Inflammasomes; Inflammation; Lipopolysaccharides | 2021 |
Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Catechin; Cathepsin B; Cytokines; Dinoprostone; Gou | 2020 |
Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice.
Topics: Animals; Cytokines; Diet, High-Fat; Disease Models, Animal; Edema; Gout; Inflammation; Mice; Mice, I | 2020 |
Discovery of a novel rice-derived peptide with significant anti-gout potency.
Topics: Animals; Edema; Female; Gout; Hyperuricemia; Inflammasomes; Inflammation; Interleukin-1beta; Kidney; | 2020 |
Ecce urate.
Topics: Humans; Hyperuricemia; Inflammation; Postoperative Complications; Uric Acid | 2021 |
Elevated serum uric acid is associated with a greater inflammatory response and with short- and long-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Topics: Aged; Biomarkers; C-Reactive Protein; Female; Humans; Hyperuricemia; Inflammation; Inflammation Medi | 2021 |
Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Asteraceae; Bridged-R | 2021 |
Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Survival; Disease Models, Animal; Glucose; HMGB1 Protein; Inf | 2021 |
HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-
Topics: Adult; Animals; Antioxidants; Arthritis, Experimental; Case-Control Studies; Chaperonin 60; Gout; Hu | 2020 |
Predictive Value of Thyroid Hormones for Incident Hyperuricemia in Euthyroid Subjects: The Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study.
Topics: Adult; Cohort Studies; Female; Humans; Hyperuricemia; Inflammation; Male; Risk Factors; Thyroid Horm | 2021 |
Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome.
Topics: Animals; Cytoprotection; Fibrosis; Inflammation; Kidney; Male; Metabolic Syndrome; Morpholines; Pyra | 2021 |
Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients.
Topics: Aged; Aged, 80 and over; Albuminuria; Aldehydes; Antioxidants; Azotemia; Biomarkers; Body Compositio | 2021 |
Nifuroxazide suppresses UUO-induced renal fibrosis in rats via inhibiting STAT-3/NF-κB signaling, oxidative stress and inflammation.
Topics: Animals; Fibrosis; Hydroxybenzoates; Inflammation; Kidney; Kidney Diseases; Male; NF-kappa B; Nitrof | 2021 |
MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3.
Topics: Animals; Arthritis, Rheumatoid; Caspase 1; Down-Regulation; Fibroblasts; Inflammation; Interleukin-1 | 2021 |
MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3.
Topics: 3' Untranslated Regions; Animals; Arthritis, Gouty; Binding Sites; Disease Models, Animal; Down-Regu | 2021 |
Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage.
Topics: Administration, Oral; Animals; Cells, Cultured; Disease Models, Animal; DNA, Mitochondrial; Gout; In | 2021 |
Relationship between seaweeds consumption and hyperuricaemia in general adults: a Population-based study from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) cohort study.
Topics: Adult; China; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Inflammation; | 2022 |
Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota.
Topics: Animals; Diet, High-Fat; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Inflammation; Insulin; | 2021 |
Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro.
Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbr | 2021 |
Simiao Wan attenuates monosodium urate crystal-induced arthritis in rats through contributing to macrophage M2 polarization.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arginase; Arthritis, Experimental; Drugs, C | 2021 |
Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway.
Topics: Allopurinol; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoplasmic | 2021 |
CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis.
Topics: Animals; Antigens, CD; Apoptosis; Cells, Cultured; Gout; Humans; Inflammation; Interleukin-1beta; Jo | 2021 |
Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.
Topics: Animals; Blood Urea Nitrogen; Chlorogenic Acid; Creatinine; Dietary Supplements; Gastrointestinal Mi | 2021 |
Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro.
Topics: Acute Disease; Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Interl | 2021 |
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
Topics: Abietanes; AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Female; Furans | 2021 |
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Topics: Animals; Blood Glucose; Body Weight; CARD Signaling Adaptor Proteins; Caspase 1; Chemokine CCL2; Cyt | 2021 |
Hashimoto's thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio.
Topics: Adult; Autoantibodies; Cholesterol, HDL; Female; Hashimoto Disease; Humans; Inflammation; Male; Midd | 2021 |
Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Intra-Art | 2021 |
The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Apoptosis; Blood Urea Nitrogen; Creatinine; Dose-Response | 2021 |
Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Caspase 1; Cell Culture Techniques; Cytokines; Furans; | 2021 |
Mesenchymal stem cells transplantation attenuates hyperuricemic nephropathy in rats.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Culture Techniques; Cell Survival; Fibrosis; Hyperurice | 2021 |
Metagenomic analysis revealed the potential role of gut microbiome in gout.
Topics: Adolescent; Adult; Aged; Arthritis; Bacteria; Butyrates; Diabetes Mellitus, Type 2; Dysbiosis; Fatty | 2021 |
Uric acid activates NRLP3 inflammasome in an in-vivo model of epithelial to mesenchymal transition in the kidney.
Topics: Animals; Caspase 1; Epithelial-Mesenchymal Transition; Fibrosis; Inflammasomes; Inflammation; Kidney | 2017 |
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.
Topics: Animals; Ankle; Anti-Inflammatory Agents; Antioxidants; Colchicine; Cytokines; Gout; Grape Seed Extr | 2017 |
Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake.
Topics: Cell Adhesion; Cell Line, Tumor; Cells, Cultured; Endothelium, Vascular; Glucose Transport Proteins, | 2017 |
Xanthine oxidoreductase activity is correlated with insulin resistance and subclinical inflammation in young humans.
Topics: Adiponectin; Adult; Body Mass Index; C-Reactive Protein; Chromatography, Liquid; Female; Humans; Inf | 2017 |
Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells.
Topics: Adult; Biomarkers; C-Reactive Protein; Complement C3; Cross-Sectional Studies; Dose-Response Relatio | 2017 |
The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes.
Topics: Cell Line; Cytokines; Gene Expression Regulation; Humans; Inflammasomes; Inflammation; Interleukin-8 | 2017 |
Neutrophil Extracellular Traps Stimulate Proinflammatory Responses in Human Airway Epithelial Cells.
Topics: Antibodies, Blocking; Bronchi; Cells, Cultured; Cigarette Smoking; Extracellular Traps; HMGB1 Protei | 2017 |
Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study.
Topics: Adipokines; Aged; Antioxidants; C-Reactive Protein; Diet; Diet Surveys; Female; gamma-Glutamyltransf | 2017 |
Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice.
Topics: Allopurinol; Animals; Diet, Western; Inflammation; Male; Mice; Mice, Inbred C57BL; Proteinuria; Uric | 2017 |
Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cyclooxygenase 2; Disease Models, Animal; Humans; Hypertension; Inflammatio | 2017 |
Uric acid demonstrates neuroprotective effect on Parkinson's disease mice through Nrf2-ARE signaling pathway.
Topics: Animals; Antioxidant Response Elements; Behavior, Animal; Cognition; Cytokines; Hippocampus; Inflamm | 2017 |
Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae.
Topics: Aeromonas caviae; Animals; Catfishes; Fish Diseases; Gram-Negative Bacterial Infections; Inflammatio | 2017 |
Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats.
Topics: Animals; Blood Urea Nitrogen; Hyperuricemia; Inflammasomes; Inflammation; Interleukin-1beta; Kidney; | 2017 |
Erding Formula in hyperuricaemia treatment: unfolding traditional Chinese herbal compatibility using modern pharmaceutical approaches.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drugs, Chinese Herbal; Gene E | 2018 |
Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation.
Topics: Acute Kidney Injury; Animals; Cell Proliferation; Endothelin-1; Fibroblasts; Gene Expression; Hyperu | 2017 |
Inflammatory biomarkers and radiologic measurements in never-smokers with COPD: A cross-sectional study from the CODA cohort.
Topics: Aged; Bilirubin; C-Reactive Protein; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; | 2018 |
Time Course of Oxidative Stress, Inflammation, and Muscle Damage Markers for 5 Days After a Soccer Match: Effects of Sex and Playing Position.
Topics: Adult; Athletes; Biomarkers; C-Reactive Protein; Catalase; Creatine Kinase; Exercise Test; Female; F | 2018 |
Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan.
Topics: Acute Pain; Adjuvants, Immunologic; Animals; Antioxidants; Disease Models, Animal; Flow Cytometry; G | 2018 |
A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice.
Topics: Allopurinol; Animals; Antibodies, Monoclonal; Antibody Affinity; Antioxidants; Creatinine; Cross Rea | 2018 |
Eucalyptus globulus Inhibits Inflammasome-Activated Pro-Inflammatory Responses and Ameliorate Monosodium Urate-Induced Peritonitis in Murine Experimental Model.
Topics: Animals; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cultured; Disease Models, Animal; Eucaly | 2018 |
The link between insulin resistance parameters and serum uric acid is mediated by adiposity.
Topics: Adiposity; Biomarkers; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Female; Glycated Hem | 2018 |
Body mass index is independently associated with xanthine oxidase activity in overweight/obese population.
Topics: Adult; Aged; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Inflammat | 2020 |
Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Fatty Acids; Gout; Humans; Inflammat | 2018 |
Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts.
Topics: Alarmins; C-Reactive Protein; Caspase 1; Cholesterol; Complement C5a; Complement Membrane Attack Com | 2018 |
Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation.
Topics: Animals; Blood Glucose; Blood Pressure; Carotenoids; Diosmin; Drug Therapy, Combination; Glycation E | 2018 |
Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arthritis, Gouty; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2018 |
Monosodium Urate Crystals Activate the Inflammasome in Primary Progressive Multiple Sclerosis.
Topics: Adult; Aged; Apoptosis; Caspase 1; Caspase 8; Female; Humans; Inflammasomes; Inflammation; Interleuk | 2018 |
Greater Dietary Inflammatory Index score is associated with higher likelihood of chronic kidney disease.
Topics: Adolescent; Adult; Albumins; Body Mass Index; Creatinine; Cross-Sectional Studies; Diet; Female; Geo | 2018 |
Flavonoids interfere with NLRP3 inflammasome activation.
Topics: Animals; Caspase 1; Cell Line; Flavonoids; Focal Adhesion Kinase 2; Humans; Inflammasomes; Inflammat | 2018 |
Involvement of Arterial Stiffness and Inflammation in Hyperuricemia-Related Development of Hypertension.
Topics: Adult; Ankle Brachial Index; Blood Pressure; C-Reactive Protein; Glomerular Filtration Rate; Humans; | 2018 |
Uric Acid and Hypertension Because of Arterial Stiffness.
Topics: Humans; Hypertension; Hyperuricemia; Inflammation; Uric Acid; Vascular Stiffness | 2018 |
Changes of Treg/Th17 Ratio in Spleen of Acute Gouty Arthritis Rat Induced by MSU Crystals.
Topics: Animals; Arthritis, Gouty; Cytokines; Inflammation; Lymphocyte Count; Rats; Spleen; T-Lymphocytes, R | 2018 |
A model of chronic enthesitis and new bone formation characterized by multimodal imaging.
Topics: Animals; Chronic Disease; Crystallization; Disease Models, Animal; Inflammation; Mice, Inbred BALB C | 2018 |
The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Flow Cytometry; Humans; Inflammation; Male; Middle Aged; | 2018 |
A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction.
Topics: Aged; Atherosclerosis; Biomarkers; C-Reactive Protein; Female; Homocysteine; Humans; Hyperhomocystei | 2018 |
Identification of urate hydroperoxide in neutrophils: A novel pro-oxidant generated in inflammatory conditions.
Topics: Catalysis; Cell Line, Tumor; Free Radicals; Humans; Inflammation; Mass Spectrometry; Neutrophils; Ox | 2018 |
High-mobility group box 1 is responsible for monosodium urate crystal-induced inflammation in human U937 macrophages.
Topics: Caspase 1; HMGB1 Protein; Humans; Inflammation; Inflammation Mediators; Interleukin-18; Interleukin- | 2018 |
Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling.
Topics: Acetamides; AMP-Activated Protein Kinases; Animals; Bone Marrow Cells; Cells, Cultured; Inflammation | 2018 |
Renoprotective effect of Spirulina platensis extract against nicotine-induced oxidative stress-mediated inflammation in rats.
Topics: Animals; Antioxidants; Caspase 3; Creatinine; Glutathione; Glutathione Transferase; Inflammation; In | 2018 |
Urate crystals and inflammation. Cardiovascular impact of gout.
Topics: Gout; Humans; Hyperuricemia; Inflammation; Uric Acid | 2018 |
15d-PGJ
Topics: Animals; Antioxidants; Arthritis, Experimental; Arthritis, Gouty; Inflammation; Male; Mice; Mice, In | 2018 |
Serum Uric Acid Levels are Associated with Cardiometabolic Risk Factors in Healthy Young and Middle-Aged Adults.
Topics: Adiposity; Adult; Blood Pressure; C-Reactive Protein; Cholesterol; Cross-Sectional Studies; Diet Sur | 2018 |
Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation.
Topics: Amines; Amino Acid Sequence; Enzyme Activation; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphoryl | 2018 |
Caspase-(8/3) activation and organ inflammation in a rat model of resuscitated hemorrhagic shock: A role for uric acid.
Topics: Animals; Apoptosis; Biomarkers; Caspases; Disease Models, Animal; Inflammation; Male; Rats; Rats, Wi | 2019 |
Uric acid induced inflammatory responses in endothelial cells via up-regulating(pro)renin receptor.
Topics: Cell Adhesion; Cells, Cultured; Cytokines; Endothelium, Vascular; Human Umbilical Vein Endothelial C | 2019 |
The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.
Topics: Animals; Flavonoids; Inflammation; Inflammation Mediators; Kidney Diseases; Male; Oxidative Stress; | 2019 |
Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Gouty; Cell Proliferation | 2019 |
Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model.
Topics: Allopurinol; Animals; Creatinine; Gout Suppressants; Hyperuricemia; Inflammation; Kidney; Macrophage | 2018 |
Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis.
Topics: Allopurinol; Animals; Antimetabolites; Carotid Artery Diseases; Human Umbilical Vein Endothelial Cel | 2019 |
Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy.
Topics: Allopurinol; Animals; Benzbromarone; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; | 2019 |
Phagocytosis of monosodium urate crystals by human synoviocytes induces inflammation.
Topics: Arthritis, Gouty; Cells, Cultured; Humans; Inflammation; Phagocytosis; Synoviocytes; Uric Acid | 2019 |
mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?
Topics: Cell Death; Cytokines; Gout; Humans; Inflammation; Metformin; Monocytes; Signal Transduction; TOR Se | 2019 |
TXNIP-mediated nuclear factor-κB signaling pathway and intracellular shifting of TXNIP in uric acid-induced NLRP3 inflammasome.
Topics: Carrier Proteins; Humans; Inflammasomes; Inflammation; Macrophages; NF-kappa B; NLR Family, Pyrin Do | 2019 |
Association of ideal cardiovascular health metrics with serum uric acid, inflammation and atherogenic index of plasma: A population-based survey.
Topics: Adult; Atherosclerosis; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studies; Female | 2019 |
Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Female; HL-60 Cells; Humans; Inflammation; Leptin | 2019 |
The Validity of Gout Diagnosis in Primary Care: Results from a Patient Survey.
Topics: Aged; Aged, 80 and over; Female; Gout; Humans; Inflammation; Male; Middle Aged; Primary Health Care; | 2019 |
Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation.
Topics: Animals; Disease Models, Animal; Gout; Inflammation; Interleukin-1beta; Macrophages; Male; Mice; Mic | 2019 |
A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS).
Topics: Adult; Female; Glutathione Peroxidase; Glycemic Index; Humans; Inflammation; Polycystic Ovary Syndro | 2019 |
Inhibition of Hyperuricemia and Gouty Arthritis in BALB/c Mice Using Copper Oxide Nanoparticles.
Topics: Administration, Oral; Animals; Arthritis, Gouty; Copper; Disease Models, Animal; Humans; Hyperuricem | 2020 |
Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis.
Topics: Animals; Caspase 1; Catechin; Disease Models, Animal; DNA, Mitochondrial; Gout; Humans; Inflammasome | 2019 |
Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.
Topics: Anacardiaceae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chalcone; Dose-Re | 2019 |
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Topics: Animals; Antioxidants; Catalase; Cell Survival; Cytokines; Docosahexaenoic Acids; Gout; Heme Oxygena | 2019 |
Human Cartilage Homogenates Influence the Crystallization of Monosodium Urate and Inflammatory Response to Monosodium Urate Crystals: A Potential Link Between Osteoarthritis and Gout.
Topics: Cartilage; Crystallization; Cytokines; Gout; Humans; Inflammation; Knee Joint; Osteoarthritis; Uric | 2019 |
Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures.
Topics: Adult; Age Factors; Biomarkers; Body Mass Index; Cholesterol, HDL; Disability Evaluation; Female; Ho | 2019 |
Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men.
Topics: Blood Cells; Blood Culture; Chemokine CCL2; Crystallization; Female; Humans; Inflammation; Interleuk | 2019 |
Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7.
Topics: Animals; Anti-Inflammatory Agents; Artemisinins; Arthritis; Cell Line; Cell Line, Tumor; Humans; Inf | 2019 |
MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Topics: Animals; Base Sequence; Case-Control Studies; Chemokine CCL2; Disease Models, Animal; Gene Expressio | 2019 |
Higher Pro-Inflammatory Dietary Score is Associated with Higher Hyperuricemia Risk: Results from the Case-Controlled Korean Genome and Epidemiology Study_Cardiovascular Disease Association Study.
Topics: Aged; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Diet; Feeding Behavior; Female; Hum | 2019 |
Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells.
Topics: Cell Communication; Dendritic Cells; Erythrocytes; Fluorescent Antibody Technique; Humans; Inflammat | 2013 |
Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats.
Topics: Acetic Acid; Acid Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; beta-Glu | 2013 |
Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Female; Glucuronidase; Hydrolases | 2012 |
Association of serum bilirubin and uric acid levels changes during neuroinflammation in patients with initial and relapsed demyelination attacks.
Topics: Adolescent; Adult; Bilirubin; Brain; Demyelinating Diseases; Disability Evaluation; Disease Progress | 2013 |
The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.
Topics: Animals; Antioxidants; Apoptosis; Carrier Proteins; Caspase 1; Cell Survival; Cells, Cultured; Dendr | 2013 |
Effect of bariatric surgery on the inflammatory response to monosodium urate crystals: a prospective study.
Topics: Adult; Bariatric Surgery; Body Weight; Cells, Cultured; Cytokines; Female; Gout; Humans; Inflammatio | 2013 |
Trikatu, a herbal compound that suppresses monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis.
Topics: Acute Disease; Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Female; | 2014 |
Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice.
Topics: Acute Kidney Injury; Animals; Crystallization; Diet, High-Fat; Glucose Transport Proteins, Facilitat | 2013 |
An association between body mass index and high-sensitivity C-reactive protein concentrations is influenced by age in community-dwelling persons.
Topics: Adiposity; Age Factors; Aged; Biomarkers; Blood Glucose; Body Mass Index; C-Reactive Protein; Choles | 2013 |
Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents.
Topics: Acetanilides; Acute Pain; Animals; Arthritis, Gouty; Disease Models, Animal; Hydrogen Peroxide; Infl | 2013 |
Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease.
Topics: Apolipoproteins B; Biomarkers; Cholesterol, HDL; Cohort Studies; Coronary Disease; Diabetes Mellitus | 2013 |
Transient receptor potential melastatin 2: a novel target for treatment of gout.
Topics: Gout; Humans; Inflammation; TRPM Cation Channels; Uric Acid | 2013 |
Participation of the TRPV1 receptor in the development of acute gout attacks.
Topics: Acute Disease; Anilides; Animals; Arthralgia; Cinnamates; Disease Models, Animal; Gout; Inflammation | 2014 |
Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.
Topics: Adult; Antioxidants; Aspartate Aminotransferases; Blood Glucose; C-Reactive Protein; Cholesterol; Cr | 2013 |
Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.
Topics: Adiponectin; Adult; Aged; Aryldialkylphosphatase; Biomarkers; Blood Glucose; Blood Pressure; Body Ma | 2013 |
High-density lipoproteins inhibit urate crystal-induced inflammation in mice.
Topics: Animals; Back; Chemokine CCL2; Chemokine CXCL1; Disease Models, Animal; Gout; Inflammation; Interleu | 2015 |
A microcycle of inflammation following a team handball game.
Topics: Ammonia; Athletic Performance; Blood Glucose; C-Reactive Protein; Creatine Kinase; Cytokines; Exerci | 2014 |
Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout.
Topics: Adult; Aged; Aged, 80 and over; Animals; Calgranulin A; Calgranulin B; Cells, Cultured; Crystallizat | 2014 |
Pentraxin 3 as a novel bio-marker of inflammation and endothelial dysfunction in autosomal dominant polycystic kidney disease.
Topics: Adult; Biomarkers; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Endothelium, V | 2014 |
Immunomodulatory activities of Yoyo bitters: recommended dose precipitated inflammatory responses in male Wistar rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Eating; Immunologic Factors; Inflammation; Inflamma | 2013 |
Influence of protein intake from haem and non-haem animals and plant origin on inflammatory biomarkers among apparently-healthy adults in Greece.
Topics: Adult; Animals; Biomarkers; C-Reactive Protein; Creatinine; Cystatin C; Diet; Diet Records; Dietary | 2013 |
Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010.
Topics: Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperu | 2014 |
Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
Topics: Animals; Cell Death; Cell Line; Inflammation; Lectins, C-Type; Mice; Mice, Knockout; Models, Biologi | 2014 |
Clec12a: quieting the dead.
Topics: Animals; Cell Death; Inflammation; Lectins, C-Type; Receptors, Mitogen; Uric Acid | 2014 |
Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines.
Topics: Animals; Cell Aggregation; Chemokines; Cytokines; Gout; Humans; Inflammation; Mice; Neutrophils; Res | 2014 |
An MRI assessment of chronic synovial-based inflammation in gout and its correlation with serum urate levels.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Gout; Humans; Inflammation; Knee Joint; Magnetic Reson | 2015 |
Increased circulating inflammatory markers may indicate that formula-fed children are at risk of atherosclerosis.
Topics: Atherosclerosis; Biomarkers; Breast Feeding; Chemokine CCL2; Child, Preschool; Female; Humans; Infan | 2014 |
The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study.
Topics: Adult; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cross-S | 2014 |
The anti-inflammatory and antioxidant effects of pravastatin and nebivolol in rat aorta.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Aorta; Ceruloplasmin; Cholesterol; Coronary Artery | 2014 |
Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.
Topics: Animals; Arthritis, Experimental; Arthritis, Gouty; Humans; Immunity, Innate; Inflammation; Interleu | 2014 |
Association between serum uric acid and inflammation in rheumatoid arthritis: perspective on lowering serum uric acid of leflunomide.
Topics: Aged; Arthritis, Rheumatoid; Female; Glomerular Filtration Rate; Humans; Inflammation; Isoxazoles; L | 2015 |
Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells.
Topics: Carrier Proteins; Cell Line, Tumor; Gout; Heme Oxygenase-1; Humans; Inflammation; Interleukin-1beta; | 2015 |
Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function.
Topics: Allopurinol; Animals; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Humans; Hypoxia-Inducibl | 2014 |
Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?
Topics: Cell Line; Chondroitin Sulfates; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gou | 2014 |
Hyperuricemic PRP in tendon cells.
Topics: Adult; Cell Proliferation; Extracellular Matrix; Extracellular Matrix Proteins; Gene Expression Regu | 2014 |
Renal "hyperfiltrators" are at elevated risk of death and chronic diseases.
Topics: Adult; Aged; Autoimmunity; Blood Pressure; Body Mass Index; Cause of Death; Cholesterol, LDL; Chroni | 2014 |
Fermented soy permeate reduces cytokine level and oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Diabet | 2015 |
Serum uric acid as a clinically useful nutritional marker and predictor of outcome in maintenance hemodialysis patients.
Topics: Aged; Aged, 80 and over; Biomarkers; Body Composition; Body Mass Index; Creatinine; Energy Intake; F | 2015 |
Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
Topics: Animals; Aporphines; Carrier Proteins; Cell Line; Humans; Hyperuricemia; Inflammasomes; Inflammation | 2015 |
Gout, tophi and the wonders of NETs.
Topics: Animals; Arthritis, Gouty; Extracellular Traps; Gout; Humans; Inflammation; Uric Acid | 2014 |
Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Cysteine; Cystine; Disulfides; Glutathione; Inflam | 2015 |
Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Case-Control Studies; Cytokines; Enzyme-Linked Immunos | 2016 |
Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy.
Topics: Animals; Carrier Proteins; Cell Line; Chemokine CXCL12; Coculture Techniques; Diabetes Mellitus, Typ | 2015 |
Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in gout.
Topics: Acetanilides; Animals; Cytokines; Disease Models, Animal; Gout; Inflammation; Mice; Mice, Knockout; | 2015 |
Geraniol, alone and in combination with pioglitazone, ameliorates fructose-induced metabolic syndrome in rats via the modulation of both inflammatory and oxidative stress status.
Topics: Acyclic Monoterpenes; Adiponectin; Adipose Tissue; Adiposity; Animals; Blood Pressure; Body Weight; | 2015 |
Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation.
Topics: Administration, Intranasal; Animals; Antigens, Dermatophagoides; Apoptosis Regulatory Proteins; Calc | 2015 |
Activation of peripheral KCNQ channels relieves gout pain.
Topics: Action Potentials; Animals; Animals, Newborn; Arthritis; Benzbromarone; Cells, Cultured; CHO Cells; | 2015 |
The relationship between vascular inflammation and target organ damage in hypertensive crises.
Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chemokine CCL2; Emergency Service, Ho | 2015 |
NLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation.
Topics: Carrier Proteins; Caspase 1; Cells, Cultured; Cytokines; HEK293 Cells; Humans; Immunity, Innate; Inf | 2015 |
EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy.
Topics: Animals; Chemokines; Cytokines; Disease Progression; ErbB Receptors; Fibroblasts; Fibrosis; Gefitini | 2015 |
Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Animals; Diet, High-Fat; Electrocardiography; Enz | 2015 |
The metastatic tumor antigen 1-transglutaminase-2 pathway is involved in self-limitation of monosodium urate crystal-induced inflammation by upregulating TGF-β1.
Topics: Animals; Arthritis, Gouty; Cell Line; GTP-Binding Proteins; Histone Deacetylases; Humans; Inflammati | 2015 |
Hepatic, renal and inflammatory biomarkers are positively associated with blood pressure changes in healthy pregnant women: a prospective cohort.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Biomarkers; Blood Pr | 2015 |
Gout: cartoonized and bagatellized and still left untreated. Time to change.
Topics: Allopurinol; Arthritis; Cartoons as Topic; Gout; History, 19th Century; History, 20th Century; Histo | 2015 |
Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging.
Topics: Aged, 80 and over; Biomarkers; Brazil; C-Reactive Protein; Coronary Artery Disease; Coronary Vessels | 2016 |
Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders.
Topics: Animals; Biomarkers; Blood-Brain Barrier; Dyslipidemias; Gliosis; Glucose Tolerance Test; Humans; Hy | 2015 |
Differential proteomics of monosodium urate crystals-induced inflammatory response in dissected murine air pouch membranes by iTRAQ technology.
Topics: Air Sacs; Animals; Chromatography, Liquid; Gene Expression Regulation; Inflammation; Male; Mice; Pro | 2015 |
Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation.
Topics: Animals; Calcium; Carrier Proteins; Catechin; Disease Models, Animal; Free Radical Scavengers; Galli | 2015 |
Contribution of Inflammation, Oxidative Stress, and Antioxidants to the Relationship between Sleep Duration and Cardiometabolic Health.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Blood Pressure; C-Reactive Protein; Cardiovascular Physiol | 2015 |
Positive correlation between uric acid and C-reactive protein serum level in healthy individuals and patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cross-Secti | 2015 |
Uric acid correlates to oxidation and inflammation in opposite directions in women.
Topics: Aged; Biomarkers; C-Reactive Protein; Case-Control Studies; Chromatography, Liquid; F2-Isoprostanes; | 2015 |
Oral treatment with Bifidobacterium longum 51A reduced inflammation in a murine experimental model of gout.
Topics: Administration, Oral; Animals; Bifidobacterium; Cytokines; Disease Models, Animal; Gout; Gout Suppre | 2015 |
Metabolic syndrome is associated with decreased circulating endothelial progenitor cells and increased arterial stiffness in systemic lupus erythematosus.
Topics: Adult; Aged; Arteries; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies | 2016 |
Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout.
Topics: Animals; Disease Models, Animal; Gout; Hyperalgesia; Inflammation; Interleukin-1beta; Knee Joint; Ma | 2016 |
Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1β Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells.
Topics: Alanine; Ascorbic Acid; Caspase 1; Cell Line; Colchicine; Dexamethasone; Enzyme Activation; Gout; Hu | 2016 |
Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation.
Topics: Adenosine Triphosphate; Animals; Caspase 1; Cells, Cultured; Deoxyglucose; Humans; Inflammasomes; In | 2015 |
Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003-2008.
Topics: Adolescent; Biomarkers; C-Reactive Protein; Child; Environmental Pollutants; Female; gamma-Glutamylt | 2016 |
Serum uric acid and inflammation in patients with immune thrombocytopenic purpura: preliminary results.
Topics: Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Cytokines; Female; Humans; Inflammat | 2015 |
Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Cell Line; Chemokine CCL2; Colchicine; Cyclooxy | 2015 |
Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents.
Topics: Adolescent; Female; Humans; Inflammation; Male; Metabolic Syndrome; Parathyroid Hormone; Pediatric O | 2016 |
Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Coumaric Acids; Drug Delivery Systems; Edema; F | 2016 |
Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout.
Topics: Acute Disease; Animals; Disease Models, Animal; Female; Gout; Humans; Inflammation; Injections; Inte | 2016 |
Obesity and Age-Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations.
Topics: Adult; Aged; Aging; Biomarkers; Blood Pressure; Body Mass Index; C-Reactive Protein; Cholesterol, HD | 2016 |
Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Apoptosis Regulatory Prote | 2016 |
Enhanced p62 Is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1β Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage.
Topics: Animals; Apoptosis; Gout; Inflammation; Interleukin-1beta; Macrophages; Metabolic Networks and Pathw | 2016 |
Impact of Elevated Serum Uric Acid Levels on Systemic Inflammation in Patients With Psoriasis.
Topics: Adult; Biomarkers; Case-Control Studies; Female; Humans; Inflammation; Inflammation Mediators; Lymph | 2017 |
Serum Procalcitonin as a Useful Serologic Marker for Differential Diagnosis between Acute Gouty Attack and Bacterial Infection.
Topics: Area Under Curve; Arthritis, Gouty; Bacterial Infections; Biomarkers; Blood Sedimentation; C-Reactiv | 2016 |
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease.
Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Fema | 2016 |
Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice.
Topics: Acetates; Animals; Apoptosis; Caspases; Crystallization; Diet, High-Fat; Dietary Fiber; Disease Mode | 2017 |
Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice.
Topics: Animals; Carrier Proteins; Flavonols; Hyperuricemia; Inflammasomes; Inflammation; Janus Kinase 2; Ki | 2016 |
Poorly controlled gout: who is doing poorly?
Topics: Allopurinol; Arthritis; Comorbidity; Gout; Humans; Hyperuricemia; Inflammation; Medication Adherence | 2016 |
Disease Duration and Inflammation in Psoriasis.
Topics: Humans; Inflammation; Psoriasis; Uric Acid | 2017 |
Efficacy of CoenzymeQ10 in inhibiting monosodium urate crystal-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Edema; Female; Inflammation; Lipid Peroxidation | 2016 |
Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Topics: Animals; CARD Signaling Adaptor Proteins; Focal Adhesion Kinase 2; Inflammasomes; Inflammation; Mice | 2016 |
Gout: will the "King of Diseases" be the first rheumatic disease to be cured?
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Gout; Gout Suppressants; Humans; Inflammation; Pain; | 2016 |
Associations of VCAM-1 gene polymorphisms with obesity and inflammation markers.
Topics: Adult; Asian People; C-Reactive Protein; Female; Gene Frequency; Genetic Predisposition to Disease; | 2017 |
Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease.
Topics: Biomarkers; Bronchoalveolar Lavage Fluid; Child, Preschool; Cystic Fibrosis; Early Diagnosis; Female | 2017 |
Uric Acid Is Associated With Inflammation, Coronary Microvascular Dysfunction, and Adverse Outcomes in Postmenopausal Women.
Topics: Aged; Biomarkers; Coronary Artery Disease; Coronary Circulation; Coronary Vessels; Endothelium, Vasc | 2017 |
Annexin A1 promotes timely resolution of inflammation in murine gout.
Topics: Animals; Annexin A1; Anti-Inflammatory Agents; Antibodies, Blocking; Apoptosis; Cell Movement; Disea | 2017 |
Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats.
Topics: Alkaloids; Animals; Arthritis, Gouty; Berberine; Carrier Proteins; Female; Inflammation; Isoquinolin | 2017 |
Correlation between Inflammatory Biomarkers and Red Blood Cell Life Span in Chronic Hemodialysis Patients.
Topics: Adult; Aged; Anemia; Biomarkers; Blood Urea Nitrogen; Erythrocyte Aging; Female; Humans; Inflammatio | 2017 |
Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway.
Topics: Cell Adhesion; Cytokines; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Gene Expression | 2017 |
Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: Associations with inflammatory and oxidative stress biomarkers and uric acid.
Topics: Adult; Atherosclerosis; Biomarkers; C-Reactive Protein; Case-Control Studies; Depressive Disorder; F | 2017 |
Cockroach protease allergen induces allergic airway inflammation via epithelial cell activation.
Topics: Administration, Intranasal; Allergens; Animals; Antigens, CD; Cell Membrane Permeability; Cell Movem | 2017 |
β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Animals; Diet, Ketogenic; Female; Gout; Humans; Infl | 2017 |
Inflammatory status and uricaemia determine HDL-cholesterol levels in hypertensive adults over 65: an analysis of the FAPRES register.
Topics: Aged; Biomarkers; Chi-Square Distribution; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studi | 2017 |
Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes.
Topics: Animals; Bursa, Synovial; Crystallization; Female; Gene Expression Profiling; Inflammation; Mice; Mi | 2008 |
Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction.
Topics: Adipokines; Biomarkers; Cross-Sectional Studies; Endothelium, Vascular; Humans; Inflammation; Inflam | 2008 |
Uric acid: the oxidant-antioxidant paradox.
Topics: Animals; Antioxidants; Humans; Inflammation; Oxidants; Uric Acid | 2008 |
High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles.
Topics: Adult; Atherosclerosis; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Female; Fibrinogen; | 2009 |
Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells.
Topics: Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Gene Expression Regulation, Enzymologic; Glut | 2008 |
The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dipyrone; Dose-Respon | 2008 |
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Benzofurans; Depsid | 2008 |
Co-associations between insulin sensitivity and measures of liver function, subclinical inflammation, and hematology.
Topics: Blood; Cluster Analysis; Cohort Studies; Coronary Disease; Cross-Sectional Studies; Diabetes Mellitu | 2008 |
Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Bronchoalveolar Lavage Fl | 2009 |
Discontinuous drug combination therapy in autoimmune ocular disorders.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Blood Pressure; Drug Resistance; Dr | 2009 |
A pilot study: sodium urate synovitis as an acute model of inflammatory response using objective and subjective criteria to evaluate arthritic pain in cats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Area Under Curve; Cats; Female; Infl | 2008 |
"Dangerous crystals".
Topics: Animals; Cell Membrane; Cholesterol; Dendritic Cells; Fibroblasts; Inflammation; Intracellular Signa | 2008 |
NALP3 inflammasome functional polymorphisms and gout susceptibility.
Topics: Carrier Proteins; Genetic Predisposition to Disease; Gout; Humans; Inflammation; Interleukin-1beta; | 2009 |
Synergy between adiposity, insulin resistance, metabolic risk factors, and inflammation in adolescents.
Topics: Adolescent; Alanine Transaminase; Australia; C-Reactive Protein; Cardiovascular Diseases; Cholestero | 2009 |
Inhibition of monosodium urate crystal-induced inflammation by withaferin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ergosterol; | 2008 |
A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; B-Lymphocytes; Chromatography, High Pressur | 2009 |
Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Female; Health Status; Health Survey | 2009 |
Association of uric acid with inflammation, progressive renal allograft dysfunction and post-transplant cardiovascular risk.
Topics: Adult; C-Reactive Protein; Cardiovascular Diseases; Female; Glomerular Filtration Rate; Humans; Hype | 2009 |
Inflammasome-mediated regulation of hepatic stellate cells.
Topics: Actins; Animals; Apoptosis Regulatory Proteins; Calcium Signaling; Carbon Tetrachloride; CARD Signal | 2009 |
Malnutrition-inflammation complex syndrome and hepatitis C in maintenance hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; Creatinine; Femal | 2009 |
Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response.
Topics: Allopurinol; Animals; Erythrocytes; Humans; Inflammation; Inflammation Mediators; Plasmodium falcipa | 2009 |
Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Cells, Cultured; Crystallization; Do | 2009 |
Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C.
Topics: Cells, Cultured; Enzyme Activation; Humans; Inflammation; Intracellular Signaling Peptides and Prote | 2009 |
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.
Topics: Allopurinol; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Protei | 2009 |
Sodium and potassium urate crystals differ in their inflammatory potential.
Topics: Flow Cytometry; Humans; Inflammation; Microscopy, Electron, Scanning; Reactive Oxygen Species; Uric | 2009 |
6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Catechols; Crystallization; Dose-Res | 2010 |
Out with gout: opening the door on acute inflammation.
Topics: Acute Disease; Adaptive Immunity; Gout; Humans; Inflammation; Uric Acid | 2010 |
Insulin resistance-related biomarker clustering and subclinical inflammation as predictors of cancer mortality during 21.5 years of follow-up.
Topics: Biomarkers; Blood Glucose; Cholesterol, HDL; England; Follow-Up Studies; Glucose Intolerance; Humans | 2010 |
High inflammatory activity related to the number of metabolic syndrome components.
Topics: Blood Cell Count; Body Mass Index; C-Reactive Protein; Case-Control Studies; Female; Fibrinogen; Hum | 2010 |
Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Camellia; Drug Evaluation, Preclinical; Female; Infla | 2010 |
Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung.
Topics: Adenosine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Disease Mod | 2010 |
Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome.
Topics: Acute Disease; Adult; Aged; Biomarkers; Blood Transfusion; Blood Urea Nitrogen; C-Reactive Protein; | 2010 |
Uric acid promotes an acute inflammatory response to sterile cell death in mice.
Topics: Animals; Cell Death; Cells; Immune System; Inflammation; Mice; Mice, Inbred C57BL; Mice, Inbred Stra | 2010 |
Caught red-handed: uric acid is an agent of inflammation.
Topics: Animals; Antineoplastic Agents; Cell Death; Inflammation; Liver; Mice; Signal Transduction; Uric Aci | 2010 |
The association of serum uric acid levels with outcomes following percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Cohort Studies; Confidence Intervals; Coronary Artery Disease; | 2010 |
Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis.
Topics: Animals; Apoptosis Regulatory Proteins; Arthritis, Gouty; CARD Signaling Adaptor Proteins; Caspase 1 | 2010 |
[Plasma antioxidant activity--a test for impaired biological functions of endoecology, exotrophy, and inflammation reactions].
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Electrochemical Techniques; Humans; Inf | 2010 |
The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives.
Topics: Adiponectin; Adult; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Hypertension; Infla | 2011 |
Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Antioxidants; Carrier Proteins; Caspase 1; H | 2010 |
Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure.
Topics: Adipokines; Aged; Biomarkers; Case-Control Studies; Chitinase-3-Like Protein 1; Creatinine; Enzyme-L | 2010 |
Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients.
Topics: Adult; Age Factors; Aged; Brain Ischemia; Female; Humans; Inflammation; Kidney Failure, Chronic; Mal | 2011 |
Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation.
Topics: Allantoin; Cardiovascular Diseases; Humans; Hydrogen Peroxide; Hyperuricemia; Inflammation; NADPH Ox | 2011 |
Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation.
Topics: Adolescent; Biomarkers; Child; Female; Humans; Inflammation; Insulin Resistance; Male; Nitrates; Nit | 2011 |
Uric acid and pentraxin-3 levels are independently associated with coronary artery disease risk in patients with stage 2 and 3 kidney disease.
Topics: Aged; C-Reactive Protein; Coronary Angiography; Coronary Artery Disease; Disease Progression; Female | 2011 |
Effect of acupuncture on rats with acute gouty arthritis inflammation: a metabonomic method for profiling of both urine and plasma metabolic perturbation.
Topics: Acupuncture Therapy; Animals; Arthritis, Gouty; Chromatography, High Pressure Liquid; Disease Models | 2011 |
Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease.
Topics: Aged; Biomarkers; Coronary Artery Disease; Diabetes Mellitus; Female; Humans; Hyperuricemia; Inflamm | 2011 |
Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout.
Topics: Animals; Blotting, Western; Cell Differentiation; Disease Models, Animal; Flow Cytometry; Gout; Infl | 2011 |
The effect of montelukast in a model of gouty arthritis induced by sodium monourate crystals.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Cell Migration Assays, | 2011 |
Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease.
Topics: Aged; Analysis of Variance; Blood Pressure Determination; Cohort Studies; Diet, Carbohydrate-Restric | 2012 |
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study.
Topics: Adult; Aged; C-Reactive Protein; Cross-Sectional Studies; Cytokines; Female; Flow Cytometry; Humans; | 2011 |
Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress.
Topics: Adiponectin; Adult; Antioxidants; Biomarkers; Body Mass Index; C-Reactive Protein; Case-Control Stud | 2011 |
The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes.
Topics: Biomarkers; Body Mass Index; C-Reactive Protein; China; Cross-Sectional Studies; Diabetes Mellitus; | 2011 |
Lymphocyte α-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses.
Topics: Cell Line, Tumor; Enzyme Induction; Gene Expression Profiling; Genetic Predisposition to Disease; Go | 2011 |
Inflammatory biomarkers and oxidative stress measurements in patients with systemic lupus erythematosus with or without metabolic syndrome.
Topics: Acute-Phase Proteins; Adult; Biomarkers; C-Reactive Protein; Comorbidity; Female; Humans; Inflammati | 2011 |
The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels.
Topics: Biomarkers; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Coronary Circulatio | 2011 |
Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid.
Topics: Adenoidectomy; Adolescent; Belgium; Biomarkers; Child; Female; Follow-Up Studies; Humans; Inflammati | 2012 |
Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme-Linked Immunosorbe | 2011 |
Hyperuricaemia and gout.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diet; Gout; Gout Suppressants; Hum | 2011 |
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
Topics: Animals; Carrier Proteins; Caspase 1; Cytokines; Gout; Hyperalgesia; Inflammasomes; Inflammation; In | 2012 |
Dynamic pulmonary hyperinflation and low grade systemic inflammation in stable COPD patients.
Topics: Aged; Alpha-Globulins; Biomarkers; C-Reactive Protein; Chi-Square Distribution; Female; Forced Expir | 2011 |
P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals.
Topics: Animals; Antioxidants; Cell Line; Cytokines; Disease Models, Animal; Gout; Humans; Hyperuricemia; In | 2012 |
Elevated resting heart rate is associated with white blood cell count in middle-aged and elderly individuals without apparent cardiovascular disease.
Topics: Age Factors; Aged; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Choleste | 2012 |
Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Exercise; Humans; Inflammation; Lipids; | 2011 |
Markers of systemic inflammation in children with hyperuricemia.
Topics: Adolescent; Biomarkers; C-Reactive Protein; Chemokine CCL2; Child; Cross-Sectional Studies; Female; | 2012 |
Vascular endothelial function is not related to serum uric acid in healthy adults.
Topics: Adult; Aged; Biomarkers; Brachial Artery; C-Reactive Protein; Endothelium, Vascular; Female; Humans; | 2012 |
An improved acute gouty arthritis rat model and therapeutic effect of rhizoma Dioscoreae nipponicae on acute gouty arthritis based on the protein-chip methods.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Dioscorea; Disease Models, Anima | 2012 |
Metabolic syndrome: new targets for an old problem.
Topics: Animals; Endothelial Cells; Humans; Inflammation; Metabolic Syndrome; Oxidative Stress; Uric Acid | 2012 |
Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Asteraceae; Ethanol; Flavonoids; Hype | 2012 |
Correlations between serum uric acid level and disease activity, intrathecal inflammation reactivity in patients with multiple sclerosis.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Disease Progression; Female; Humans; Inflammation; In | 2012 |
Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat.
Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Chemokines; Disease | 2012 |
Effect of resistance training during Ramadan on body composition and markers of renal function, metabolism, inflammation, and immunity in recreational bodybuilders.
Topics: Adult; Biomarkers; Body Composition; Body Mass Index; Carbon Dioxide; Cholesterol, LDL; Creatinine; | 2012 |
Pathological and behavioral risk factors for higher serum C-reactive protein concentrations in free-living adults--a Brazilian community-based study.
Topics: Abdominal Fat; Adult; Aged; Aged, 80 and over; Anthropometry; Blood Glucose; Body Mass Index; Brazil | 2013 |
Inhibition of monosodium urate crystal-induced inflammation by scopoletin and underlying mechanisms.
Topics: Animals; Cell Line; Cell Survival; Cytokines; Gene Expression Regulation; Humidity; Inflammation; Le | 2012 |
Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria.
Topics: Adolescent; Child; Child, Preschool; Creatinine; Cytokines; Humans; Inflammation; Inflammation Media | 2012 |
Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice.
Topics: Animals; Blood Chemical Analysis; Body Weight; Cyclooxygenase 2; Dinoprostone; Disease Models, Anima | 2013 |
The effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on serum uric acid in patients without gout: a prospective study.
Topics: Aged; Albuminuria; C-Reactive Protein; Creatinine; Elective Surgical Procedures; Female; Gout; Human | 2013 |
Neutrophil cannibalism triggers transforming growth factor β1 production and self regulation of neutrophil inflammatory function in monosodium urate monohydrate crystal-induced inflammation in mice.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Crystallization; Cytophagocytosis; Disease Models | 2013 |
Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension.
Topics: Analysis of Variance; Biomarkers; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein; Case-Co | 2013 |
Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression.
Topics: Animals; Anthozoa; Anti-Inflammatory Agents; Arthritis, Gouty; Colchicine; Cyclooxygenase 2; Edema; | 2013 |
CD16(+) monocyte subsets are increased in large abdominal aortic aneurysms and are differentially related with circulating and cell-associated biochemical and inflammatory biomarkers.
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Biomarkers; Case-Control Studies; Fibrin Fibrin | 2013 |
A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria.
Topics: E-Selectin; Endothelium; Erythrocytes; Fibrin; Humans; Inflammation; Intercellular Adhesion Molecule | 2013 |
Is there association between uric acid and inflammation in hemodialysis patients?
Topics: Adult; Aged; Cross-Sectional Studies; Female; Humans; Inflammation; Kidney Failure, Chronic; Male; M | 2013 |
Monosodium urate monohydrate crystal-induced inflammation in vivo: quantitative histomorphometric analysis of cellular events.
Topics: Animals; Cell Count; Crystallization; Disease Models, Animal; Exudates and Transudates; Fibroblasts; | 2002 |
Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chronic Disease; Dinoprost; F2-Isoprostanes; Glutathione; Glu | 2002 |
Crystal-induced inflammation; syndromes of gout and pseudogout.
Topics: Chondrocalcinosis; Gout; Humans; Inflammation; Syndrome; Synovitis; Uric Acid | 1963 |
[THE ACUTE INFLAMMATION OF GOUT].
Topics: Colchicine; Gout; Humans; Inflammation; Pathology; Uric Acid; Uricosuric Agents | 1963 |
THE INFLAMMATORY PROCESS IN ACUTE GOUTY ARTHRITIS. I. ACTIVATION OF HAGEMAN FACTOR BY SODIUM URATE CRYSTALS.
Topics: Arthritis; Arthritis, Gouty; Blood Coagulation Factors; Factor XII; Gout; Humans; Inflammation; Phar | 1965 |
THE EFFECT OF PRETREATMENT WITH COLCHICINE ON THE INFLAMMATORY RESPONSE TO MICROCRYSTALLINE URATE: A MODEL FOR GOUTY INFLAMMATION.
Topics: Biomedical Research; Blood Chemical Analysis; Colchicine; Dosage Forms; Drug Therapy; Gout; Humans; | 1965 |
EXPERIMENTAL INVESTIGATIONS INTO THE ORIGIN OF GOUTY TOPHI.
Topics: Animals; Gout; History; Humans; Inflammation; Necrosis; Pathology; Poultry; Rabbits; Research; Uric | 1965 |
THE INFLAMMATORY RESPONSE TO INJECTED MICROCRYSTALLINE MONOSODIUM URATE IN NORMAL, HYPERURICEMIC, GOUTY, AND UREMIC SUBJECTS.
Topics: Blood Chemical Analysis; Blood Urea Nitrogen; Erythema; Geriatrics; Gout; Humans; Hyperuricemia; Inf | 1965 |
Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation.
Topics: Anti-Inflammatory Agents; Blister; Cantharidin; Cells, Cultured; Crystallization; E-Selectin; Endoth | 2004 |
Consumption of high-pressurized vegetable soup increases plasma vitamin C and decreases oxidative stress and inflammatory biomarkers in healthy humans.
Topics: Adult; Ascorbic Acid; Biomarkers; Chemokine CCL2; Diet; Diet, Mediterranean; Dinoprost; Dinoprostone | 2004 |
Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.
Topics: Animals; Blood Urea Nitrogen; Cyclooxygenase 2; Disease Progression; Enzyme Induction; Female; Genes | 2004 |
Is there any link between insulin resistance and inflammation in established preeclampsia?
Topics: Biomarkers; Case-Control Studies; Female; Humans; Inflammation; Inflammation Mediators; Insulin Resi | 2004 |
Urate oxidation in CSF and blood of patients with inflammatory disorders of the nervous system.
Topics: Allantoin; Blood-Brain Barrier; Brain; Central Nervous System Diseases; Guillain-Barre Syndrome; Hum | 2004 |
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D | 2005 |
Inflammation and tissue damage in crystal deposition diseases.
Topics: Calcium Phosphates; Calcium Pyrophosphate; Chondrocalcinosis; Disease Progression; Gout; Humans; Inf | 2005 |
Formation of 8-nitroguanine in blood of patients with inflammatory gouty arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Gouty; C-Reactive Protein; Chromatography, Hi | 2005 |
Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch.
Topics: Animals; Arthritis, Gouty; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Inflammation; | 2005 |
Gout-associated uric acid crystals activate the NALP3 inflammasome.
Topics: Animals; Calcium Pyrophosphate; Carrier Proteins; Caspase 1; Cell Line; Cells, Cultured; Chondrocalc | 2006 |
The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage.
Topics: Acute Disease; alpha-MSH; Animals; Anti-Inflammatory Agents; Blood Pressure; Carrageenan; Chemokine | 2006 |
Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals.
Topics: Acute Disease; Animals; Antibodies, Blocking; Crystallization; Cytokines; Disease Models, Animal; Do | 2006 |
Airway inflammation in cadmium-exposed rats is associated with pulmonary oxidative stress and emphysema.
Topics: Animals; Antioxidants; Ascorbic Acid; Bronchoalveolar Lavage Fluid; Cadmium; Dinoprost; Glutathione; | 2006 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In | 2006 |
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
Topics: Adaptor Proteins, Signal Transducing; Animals; Gout; Inflammation; Mice; Mice, Inbred C57BL; Mice, K | 2006 |
Serum uric acid is a determinant of metabolic syndrome in a population-based study.
Topics: Abdominal Fat; Adult; Aged; Biomarkers; Coronary Disease; Cross-Sectional Studies; Disease Susceptib | 2006 |
Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals.
Topics: Animals; Caspase 1; Chemokines, CXC; CHO Cells; Cricetinae; Crystallization; Enzyme Activation; Gout | 2006 |
Melanocortin 3 receptors control crystal-induced inflammation.
Topics: Animals; Arthritis, Experimental; Arthritis, Gouty; Disease Models, Animal; Gene Expression Regulati | 2006 |
Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Arthritis, Gouty; Cell Line; Humans; Indomethacin; In | 2006 |
Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis.
Topics: Aged; Biomarkers; C-Reactive Protein; Calcinosis; Coronary Artery Disease; Coronary Disease; Coronar | 2007 |
Cosmetic liposuction causes only transient elevation of acute inflammatory response and does not advance to oxidative and nitrosative stress.
Topics: Adipokines; Adult; C-Reactive Protein; Cell Adhesion Molecules; Female; Homocysteine; Humans; Inflam | 2007 |
Elevated uric acid and cardiovascular disease. How strong is the evidence of a pathogenetic link?
Topics: C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperuricemia; Inflammation; Risk Factors; Uric | 2007 |
RETRACTED: Effects of ethanol on monosodium urate crystal-induced inflammation.
Topics: Animals; Cell Line, Tumor; Crystallization; Ethanol; Female; Humans; Inflammation; Inflammation Medi | 2008 |
Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study.
Topics: Aged; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Dyslipidemias; Follow-Up Studies; | 2008 |
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells.
Topics: Adjuvants, Immunologic; Alum Compounds; Animals; Antibody Formation; Antigen Presentation; Antigens; | 2008 |
Plasmodium-induced inflammation by uric acid.
Topics: Animals; Culture Media, Conditioned; Dendritic Cells; Disease Models, Animal; Erythrocytes; Hypoxant | 2008 |
Inflammation in chronic heart failure.
Topics: Anti-Inflammatory Agents; Antihypertensive Agents; C-Reactive Protein; Chronic Disease; Heart Failur | 2008 |
Suppressive effects of indomethacin on crystal-induced inflammation in canine joints and on neutrophilic motility in vitro.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis; Blood Flow Velocity; Blood Pressure; Do | 1967 |
Superoxide anion generation by human neutrophils exposed to monosodium urate.
Topics: Adsorption; Complement Activation; Complement C5; Crystallization; Humans; Immunoglobulin G; In Vitr | 1982 |
Changes in plasma, tissue, and urinary nitrogen metabolites due to an inflammatory challenge.
Topics: Amino Acids; Ammonia; Animals; Chickens; Erythrocytes; Escherichia coli; Hemocyanins; Inflammation; | 1984 |
Activation of the alternative pathway of complement by monosodium urate monohydrate crystals and other inflammatory particles.
Topics: Agammaglobulinemia; Calcium Phosphates; Complement Activation; Complement C3; Complement Pathway, Al | 1983 |
Anti-inflammatory action of alpha-1-acid-glycoprotein in urate crystal inflammation.
Topics: Animals; Anti-Inflammatory Agents; Crystallization; Inflammation; Orosomucoid; Rats; Uric Acid | 1984 |
Inflammation in the rat paw due to urate crystals. Involvement of the kinin system.
Topics: Animals; Edema; Inflammation; Kinins; Leukocytes; Male; Rats; Rats, Inbred Strains; Time Factors; Ur | 1984 |
Does hyperuricemia protect from rheumatoid inflammation? A clinical study.
Topics: Arthritis, Rheumatoid; Gout; Humans; Inflammation; Uric Acid | 1984 |
Lipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystals.
Topics: Antibodies, Monoclonal; Antigen-Antibody Complex; Apolipoproteins; Apolipoproteins B; Electrophoresi | 1984 |
The effect of X-ray irradiation on the adjuvant syndrome and the inflammatory response to urate crystals.
Topics: Adjuvants, Immunologic; Animals; Blood Cell Count; Immunity; Inflammation; Leukocyte Count; Male; Or | 1983 |
Increase in microvascular permeability induced by enzymatically generated free radicals. I. In vivo study.
Topics: Animals; Capillary Permeability; Cheek; Cricetinae; Inflammation; Male; Mesocricetus; Oxygen; Uric A | 1981 |
The effects of NSAID on monosodium-urate (MSU) skin test and on other in vivo skin tests (SK/SD; PHA).
Topics: Anti-Inflammatory Agents; Female; Humans; Indomethacin; Indoprofen; Inflammation; Male; Phytohemaggl | 1980 |
Adjuvant polyarthritis. VI. Effect of oxonate-induced hyperuricemia on the development of acute inflammation, immune response and adjuvant arthritis.
Topics: Animals; Antibody Formation; Arthritis; Arthritis, Experimental; Cell Line; Diet; Edema; Immunity, C | 1981 |
Rheumatoid factor and monosodium urate crystal-neutrophil interactions in gouty inflammation.
Topics: Adult; Cell Adhesion; Crystallization; Gout; Humans; Hydrolases; Inflammation; Kinetics; Lysosomes; | 1981 |
Modification of cholesterol crystal-induced inflammation.
Topics: Animals; Arthritis; Cholesterol; Colchicine; Crystallization; Dose-Response Relationship, Drug; Fatt | 1980 |
Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats.
Topics: Administration, Oral; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis.
Topics: Calcium Pyrophosphate; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL1; Chemokines, | 1995 |
Suppression of monosodium urate crystal-induced inflammation by black currant seed oil.
Topics: Administration, Oral; Animals; Body Weight; Diet; Female; gamma-Linolenic Acid; Inflammation; Leukoc | 1994 |
Xanthine dehydrogenase and purine metabolism in man. With special reference to exercise.
Topics: Adolescent; Adult; Animals; Dogs; Exercise; Free Radicals; Humans; Hypoxanthine; Hypoxanthines; Infl | 1994 |
Complexation of iron cation by sodium urate crystals and gouty inflammation.
Topics: Chemotaxis, Leukocyte; Chlorides; Complement Activation; Crystallization; Deferoxamine; Ferric Compo | 1994 |
Changes in the proteins coating monosodium urate crystals during active and subsiding inflammation. Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model.
Topics: Aged; Animals; Apolipoproteins B; Crystallization; Gout; Humans; Immunoglobulin G; Immunohistochemis | 1993 |
Altered arachidonic acid metabolism in urate crystal induced inflammation.
Topics: Animals; Arachidonic Acid; Arthritis, Gouty; Crystallization; Disease Models, Animal; Eicosanoids; F | 1997 |
Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Experimental; Chemotaxis, Leukocyte; Female; Inflammatio | 1997 |
Tophaceous gout of the navicular bone as a cause of medial inflammatory tumor of the foot.
Topics: Adult; Alcoholism; Anorexia Nervosa; Crystallization; Female; Foot Diseases; Gout; Granuloma, Foreig | 1998 |
Crystal-induced neutrophil activation VI. Involvment of FcgammaRIIIB (CD16) and CD11b in response to inflammatory microcrystals.
Topics: Adult; Antibodies; Antigens, CD; Calcium; Crystallization; Granulocyte-Macrophage Colony-Stimulating | 1998 |
Longitudinal changes in inflammatory markers in nasal lavage of cotton workers. Relation to endotoxin exposure and lung function changes.
Topics: Adult; Albumins; Dose-Response Relationship, Drug; Dust; Endotoxins; Gossypium; Humans; Inflammation | 1998 |
Reduction in peripheral inflammation by changes in attention.
Topics: Adaptation, Psychological; Animals; Attention; Behavior, Animal; Chickens; Inflammation; Joints; Ski | 1999 |
Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis.
Topics: Animals; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Free Radical Scavengers; Inflammation; Int | 1999 |
The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent.
Topics: Acute Disease; Animals; Antigens, Viral; Blood-Brain Barrier; Borna Disease; Borna disease virus; Br | 2001 |
Involvement of peripheral cyclooxygenase-1 and cyclooxygenase-2 in inflammatory pain.
Topics: Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Inflammation; Lactones | 2002 |
Inflammatory microcrystals alter the functional phenotype of human osteoblast-like cells in vitro: synergism with IL-1 to overexpress cyclooxygenase-2.
Topics: Adjuvants, Immunologic; Alkaline Phosphatase; Calcium Pyrophosphate; Cells, Cultured; Crystallizatio | 2002 |
Observations on phagocytosis of urate crystals by polymorphonuclear leucocytes.
Topics: Animals; Cell Nucleus; Cells, Cultured; Glycogen; Humans; Inflammation; Leukocytes; Microscopy, Elec | 1975 |
Anti-inflammatory activity of thiabendazole and its relation to parasitic disease.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carrageenan; Dogs; Dracunculiasis; Female; Fe | 1975 |
Anti-prostaglandin action of colchicine.
Topics: Animals; Anti-Inflammatory Agents; Colchicine; Diphosphates; Inflammation; Male; Prostaglandin Antag | 1975 |
Arthritis: a clinical model of inflammation.
Topics: Antigen-Antibody Complex; Arthritis; Arthritis, Rheumatoid; Cartilage, Articular; Humans; Inflammati | 1977 |
[Inflammatory activity and uric acid values].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Female; Humans; Inflammation; L | 1979 |
Protective role of ceruloplasmin in inflammation.
Topics: Adult; Albumins; Animals; Arthritis, Rheumatoid; Ceruloplasmin; Copper; Female; Humans; Inflammation | 1979 |
Induction of arthritis by purified cell-derived chemotactic factor: role of chemotaxis and vascular permeability.
Topics: Animals; Arthritis; Capillary Permeability; Chemotaxis, Leukocyte; Histamine; Inflammation; Joints; | 1977 |
Scleritis associated with hyperuricaemia.
Topics: Humans; Inflammation; Male; Middle Aged; Sclera; Uric Acid | 1975 |
Experimental inflammation induced by naturally occurring microcrystalline calcium salts.
Topics: Animals; Anti-Inflammatory Agents; Calcium; Calcium Phosphates; Carrageenan; Colchicine; Copper; Dis | 1976 |
A comparison of five preparations of synthetic monosodium urate monohydrate crystals.
Topics: Crystallization; Inflammation; Leukocytes; Microscopy, Electron; Microscopy, Electron, Scanning; Pha | 1992 |
[Change in nucleic acid metabolism in patients with acute purulent processes].
Topics: DNA; Humans; Inflammation; Phosphorus; RNA; Suppuration; Uric Acid | 1991 |
Neurogenic component of different models of acute inflammation in the rat knee joint.
Topics: Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hindlimb; Inflammation; Joint | 1991 |
Comparative study of C reactive protein and serum amyloid A protein in experimental inflammation.
Topics: C-Reactive Protein; Humans; Immunodiffusion; Inflammation; Radioimmunoassay; Serum Amyloid A Protein | 1991 |
Persistence of monosodium urate crystals and low-grade inflammation in the synovial fluid of patients with untreated gout.
Topics: Adult; Aged; Aged, 80 and over; Gout; Humans; Inflammation; Leukocyte Count; Middle Aged; Neutrophil | 1991 |
Tophus-derived monosodium urate monohydrate crystals are biologically much more active than synthetic counterpart.
Topics: Blood Proteins; Crystallization; Gout; Hemolysis; Humans; Inflammation; Knee Joint; Luminescent Meas | 1991 |
Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation.
Topics: Arthritis, Gouty; Crystallization; Humans; Inflammation; Interleukin-8; Monocytes; Synovial Fluid; U | 1991 |
Effects of peptide hormones in urate crystal inflammation.
Topics: Animals; beta-Endorphin; Calcitonin; Dinoprostone; Endorphins; Fatty Acids, Essential; Inflammation; | 1985 |
Suppression of acute and chronic inflammation by dietary gamma linolenic acid.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chr | 1989 |
The gut in the acute phase response: changes in colonic and hepatic enzyme activity in response to dermal inflammation in the rat.
Topics: Acute-Phase Reaction; Animals; Carbohydrate Epimerases; Carrageenan; Carrier Proteins; Colon; Comple | 1987 |
The "switch-off" mechanism of spontaneous resolution of acute gout attack.
Topics: Acute-Phase Reaction; Calorimetry; Crystallization; Gout; Humans; Inflammation; Lymphocytes; Microsc | 1988 |
Inhibition of leucotriene B4 synthesis by BW 755c does not reduce polymorphonuclear leucocyte (PMNL) accumulation induced by monosodium urate crystals.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1988 |
Suppression of acute inflammation by 15 methyl prostaglandin E1.
Topics: Acute Disease; Alprostadil; Animals; Inflammation; Leukotriene B4; Male; N-Formylmethionine Leucyl-P | 1988 |
Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid.
Topics: Animals; Dietary Fats, Unsaturated; Dinoprostone; Eicosapentaenoic Acid; Fatty Acids; Fatty Acids, E | 1988 |
Membranolytic effects of monosodium urate monohydrate: influence of grinding.
Topics: Crystallization; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Hemolysis; Humans; In V | 1986 |
Crystal-induced inflammation in the rat subcutaneous air-pouch.
Topics: Animals; Anti-Inflammatory Agents; Calcium Pyrophosphate; Colchicine; Diphosphates; Disease Models, | 1987 |
Lack of correlation between in vitro and in vivo effects of low density lipoprotein on the inflammatory activity of monosodium urate crystals.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Humans; In Vitro Techniques; Inflammation; Lipoproteins, LDL; | 1986 |
Systemic response to local urate crystal induced inflammation in man: a possible model to study the acute phase response.
Topics: Acute Disease; Adult; Crystallization; Female; Humans; Inflammation; Leukocyte Count; Male; Models, | 1985 |
Laboratory investigations in connective tissue disease.
Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Biopsy; Connective Tissue; Dermatomyositis; Diphosph | 1972 |
Dehydroepiandrosterone (3 -hydroxy-5-androsten-17-one) metabolism in gout.
Topics: 17-Ketosteroids; Administration, Oral; Androstanes; Androsterone; Carbon Isotopes; Chromatography, G | 1972 |
Proceedings: Stabilization of lysosomes: a mechanism of action of nonsteroid anti-inflammatory drugs?
Topics: Animals; Anti-Inflammatory Agents; Body Temperature; Chickens; Inflammation; Joints; Lysosomes; Uric | 1974 |
Nephrolithiasis in inflammatory bowel disease.
Topics: Adrenocorticotropic Hormone; Adult; Calcium; Colitis, Ulcerative; Crohn Disease; Female; Humans; Ile | 1968 |
Polymorphonuclear leukocyte motility in vitro. V. Release of chemotactic activity following phagocytosis of calcium pyrophosphate crystals, diamond dust, and urate crystals.
Topics: Animals; Calcium Phosphates; Carbon; Chemotaxis; Colchicine; Crystallography; Diphosphates; Dogs; Hu | 1970 |
Intravascular degranulation of neutrophils: an important factor in inflammation?
Topics: Animals; Arthritis; Cytoplasmic Granules; Dogs; Humans; Inclusion Bodies; Inflammation; Microscopy, | 1972 |
Mechanisms of the crystal deposition diseases--gout and pseudogout.
Topics: Acid Phosphatase; Chondrocalcinosis; Diphosphates; Female; Gout; Hemolysis; Humans; Inflammation; Le | 1973 |
Ultrastructural evidence for leakage of lysosomal contents after phagocytosis of monosodium urate crystals. A mechanism of gouty inflammation.
Topics: Acid Phosphatase; Animals; Carbon; Cell Membrane; Cell Separation; Colloids; Cytoplasm; Ferritins; G | 1974 |
Leukocytes and prostaglandins in acute inflammation.
Topics: Acute Disease; Animals; Arthritis; Blood Platelets; Capillary Permeability; Cell Movement; Cell-Free | 1974 |
Effect of prostaglandins in urate crystal inflammation.
Topics: Animals; Fatty Acids, Essential; Foot; Inflammation; Prostaglandins; Rats; Temperature; Time Factors | 1974 |
A phlogistic function of prostaglandin E1 in urate crystal inflammation.
Topics: Animals; Crystallization; Edema; Fatty Acids, Essential; Hindlimb; Hot Temperature; Inflammation; Ma | 1974 |
Studies on phagocytosis. II. The effect of nonsteroidal anti-inflammatory drugs on phagocytosis and on urate crystal-induced canine joint inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Carbon Isotopes; Dogs; Dose-Respon | 1972 |
Cytotoxic drugs in an avian urate microcrystal arthritis.
Topics: Animals; Antineoplastic Agents; Arthritis; Chickens; Columbidae; Cyclophosphamide; Cytarabine; Dacti | 1973 |
Editorial: Mechanism of gouty inflammation.
Topics: Gout; Humans; Inflammation; Leukocytes; Phagocytosis; Uric Acid | 1973 |
The chronicity of inflammation and its significance in rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Animals; Antibodies; Antigens; Arthritis, Rheumatoid; Autoimmune Diseases; C | 1968 |
[Comparative studies on serum uric acid and fatty acid ester levels in ankylosing spondylitis with and without inflammatory reaction].
Topics: Blood Sedimentation; Esters; Fatty Acids; Female; Humans; Inflammation; Male; Spondylitis, Ankylosin | 1971 |
[Coagulation factors in inflammation].
Topics: Blood Coagulation; Blood Coagulation Factors; Factor XII; Fibrin; Gout; Humans; Inflammation; Phagoc | 1971 |
The inflammatory reaction to microcrystalline sodium urate.
Topics: Animals; Calcinosis; Crystallization; Dogs; Gout; History of Medicine; Humans; Inflammation; Leukocy | 1965 |
Pathogenesis and treatment of the acute attack of gout.
Topics: Acute Disease; Animals; Calculi; Colchicine; Crystallization; Dogs; Gout; Humans; Inflammation; Leuk | 1970 |
Effects of colchicine in rats with urate crystal-induced inflammation.
Topics: Adrenal Glands; Animals; Body Weight; Colchicine; Crystallization; Edema; Gout; Inflammation; Male; | 1970 |
Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Benzopyrans; Carrageenan; Cellulose; Dogs; Indomethacin; | 1970 |
[Synovial fluid in arthritis urica. Sodium urate crystals as a key to the diagnosis and pathogenesis].
Topics: Diagnosis, Differential; Female; Gout; Humans; Inflammation; Male; Synovial Fluid; Synovitis; Uric A | 1971 |
Activation of Hageman factor by sodium urate crystals.
Topics: Factor XII; Gout; In Vitro Techniques; Inflammation; Kinins; Leukocytes; Uric Acid | 1965 |