Page last updated: 2024-10-20

uric acid and Hypothyroidism

uric acid has been researched along with Hypothyroidism in 40 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effect of levothyroxine (LT4) therapy on urinary albumin excretion rate (UAER) in early type 2 diabetic nephropathy (DN) and subclinical hypothyroidism (SCH) patients with mildly increased thyroid stimulating hormone (TSH) levels and serum thyroid peroxidase antibody (TPO-Ab) positivity."9.20Can levothyroxine treatment reduce urinary albumin excretion rate in patients with early type 2 diabetic nephropathy and subclinical hypothyroidism? A randomized double-blind and placebo-controlled study. ( Chen, X; Chen, Y; Liu, P; Liu, R; Wang, D; Wang, Y; Zhang, F, 2015)
"To determine the relationship between serum uric acid (SUA) and creatinine (SCr) in patients with hypothyroidism."7.81[The Association Between Serum Uric Acid and Creatinine in Patients with Hypothyroidism]. ( He, H; Jia, D; Li, SQ; Li, ZP; Liang, LB; Tang, GH; Zhang, M, 2015)
"To investigate the changes of blood lipid, fasting blood glucose and blood uric acid and its clinical significance in people with subclinical hypothyroidism."7.79[Blood lipid, glucose and uric acid in people with subclinical hypothyroidism]. ( Huang, HJ; Li, SQ; Liang, LB; Wang, YJ; Zhang, M, 2013)
"To investigate the effect of levothyroxine (LT4) therapy on urinary albumin excretion rate (UAER) in early type 2 diabetic nephropathy (DN) and subclinical hypothyroidism (SCH) patients with mildly increased thyroid stimulating hormone (TSH) levels and serum thyroid peroxidase antibody (TPO-Ab) positivity."5.20Can levothyroxine treatment reduce urinary albumin excretion rate in patients with early type 2 diabetic nephropathy and subclinical hypothyroidism? A randomized double-blind and placebo-controlled study. ( Chen, X; Chen, Y; Liu, P; Liu, R; Wang, D; Wang, Y; Zhang, F, 2015)
" Correlations between SA and atherosclerosis indicators, such as CIMT, LDL, hs-CRP, and uric acid, in hypothyroid individuals suggest that SA may be an indicator of atherogenesis in these patients."3.85Serum Total Sialic Acid Level is Elevated in Hypothyroid Patients as an Atherosclerotic Risk Factor. ( Aktürk, M; Altay, M; Arslan, M; Ateş, İ; Bukan, N; Çakır, N; Cerit, ET; Karakoç, MA; Yılmaz Demirtaş, C, 2017)
"To determine the relationship between serum uric acid (SUA) and creatinine (SCr) in patients with hypothyroidism."3.81[The Association Between Serum Uric Acid and Creatinine in Patients with Hypothyroidism]. ( He, H; Jia, D; Li, SQ; Li, ZP; Liang, LB; Tang, GH; Zhang, M, 2015)
"To investigate the changes of blood lipid, fasting blood glucose and blood uric acid and its clinical significance in people with subclinical hypothyroidism."3.79[Blood lipid, glucose and uric acid in people with subclinical hypothyroidism]. ( Huang, HJ; Li, SQ; Liang, LB; Wang, YJ; Zhang, M, 2013)
"The non-traditional risk factors for atherosclerotic lesions of the cardiovascular system (C-reactive protein, uric acid, fibrinogen, homocysteine) in blood plasma of patients with manifestative hypothyroidism at the age of 23 to 73 years were assessed in the study."3.79[Atypical risk factors of atherosclerosis in patients with hypothyroidism]. ( Mykhaĭlenko, OIu, 2013)
" Conditions known to increase uric acid production (psoriasis, chronic bronchitis) and to decrease uric acid excretion (hypothyroidism, metabolic syndrome, and nephroangiosclerosis) may operate in a single patient, illustrating the dramatic clinical course of untreated gout."3.74An unusual patient with hypothyroidism, tophaceous gout, and marked joint destruction. ( Fraile, JM; Montoya, F; Puig, JG; Torres, RJ, 2008)
" With the impression of primary hypothyroidism, the patient was started on levothyroxine supplementation at which point he developed a classic gouty arthritis of right first metatarsophalangial joint."3.70Reversible renal insufficiency, hyperuricemia and gouty arthritis in a case of hypothyroidism. ( Bastani, B; Mooraki, A, 1998)
"The effects of hyperthyroidism on uric acid metabolism were investigated."3.69Hyperuricemia in patients with hyperthyroidism due to Graves' disease. ( Aizawa, T; Komiya, I; Sato, A; Shinoda, T; Shirota, T; Takemura, Y; Yamada, T, 1995)
"Hypothyroidism is a frequently diagnosed endocrine disorder that has characteristic clinical signs and symptoms."2.37Unusual manifestations of hypothyroidism. ( Klein, I; Levey, GS, 1984)
" In contrast, supplemental T(3) decreased IVL in euthyroid birds, regardless of the dosing interval, but had no effect on ME activity."1.32Methimazole and thyroid hormone replacement in broilers. ( McMurtry, JP; Rosebrough, RW, 2003)
"A 20-day-old male infant presented with acute renal failure."1.29Lesch-Nyhan syndrome presenting with renal insufficiency in infancy and transient neonatal hypothyroidism. ( Hallett, RJ; Hull, RG; Jenkins, EA, 1994)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199020 (50.00)18.7374
1990's3 (7.50)18.2507
2000's7 (17.50)29.6817
2010's7 (17.50)24.3611
2020's3 (7.50)2.80

Authors

AuthorsStudies
Shabana, HS1
Allam, MA1
Nassar, YA1
Awad, A1
Naguib, MM1
Elgendy, AA1
Elmahdi, E1
Ricchi, P1
Meloni, A1
Pistoia, L1
Spasiano, A1
Rita Gamberini, M1
Maggio, A1
Gerardi, C1
Messina, G1
Campisi, S1
Allò, M1
Renne, S1
Righi, R1
Midiri, M1
Positano, V1
Filosa, A1
Pepe, A1
Desideri, G1
Bocale, R1
D'Amore, AM1
Carnassale, G1
Necozione, S1
Barini, A2
Lombardi, CP1
Liang, LB2
Zhang, M2
Huang, HJ1
Wang, YJ1
Li, SQ2
Mykhaĭlenko, OIu1
Ye, Y1
Gai, X1
Xie, H1
Jiao, L1
Zhang, S1
Zhang, J1
Meng, Z1
Zhang, Q1
Liu, L1
Song, K1
Tan, J1
Li, X1
Jia, Q1
Zhang, G1
He, Y1
Liu, P1
Liu, R1
Chen, X1
Chen, Y1
Wang, D1
Zhang, F1
Wang, Y1
Jia, D1
Tang, GH1
He, H1
Li, ZP1
Altay, M1
Karakoç, MA1
Çakır, N1
Yılmaz Demirtaş, C1
Cerit, ET1
Aktürk, M1
Ateş, İ1
Bukan, N1
Arslan, M1
Montoya, F1
Torres, RJ1
Fraile, JM1
Puig, JG1
Sugiyama, T1
Shichiri, M1
Hirata, Y1
Rosebrough, RW1
McMurtry, JP1
Dariyerli, N1
Andican, G1
Catakoğlu, AB1
Hatemi, H1
Burçak, G1
Tanaci, N1
Ertugrul, DT1
Sahin, M1
Yucel, M1
Olcay, I1
Demirag, NG1
Gursoy, A1
Empson, M1
Flood, V1
Ma, G1
Eastman, CJ1
Mitchell, P1
Klein, I1
Levey, GS1
Mertz, DP1
Keller, U1
Staub, JJ1
Hauenstein, M1
Müller, J1
Neradilová, M1
Zofková, I1
Simecková, A1
Reisenauer, R2
Sato, A1
Shirota, T1
Shinoda, T1
Komiya, I1
Aizawa, T1
Takemura, Y1
Yamada, T1
Jenkins, EA1
Hallett, RJ1
Hull, RG1
Mooraki, A1
Bastani, B1
Gonzalez Ruíz, A1
Bernal Ruíz, AI1
Aragoneses Fraile, H1
Peral Martinez, I1
García Muñoz, M1
Sany, J1
Rosenberg, F1
Bataille, R1
Serre, H1
Gilroy, J1
Davis, PJ1
Davis, FB1
Utiger, RD1
Kulaga, SF1
Segers, AM1
de Forteza, IE1
Conforti, FY1
Abulafia, J1
Wallace, RB1
Pomrehn, P1
Heiss, G1
Chambless, LE1
Johnson, N1
Patten, R1
Lippel, K1
Rifkind, BM1
Boyle, JA1
Greig, WR1
Duncan, AM1
Boyle, IT1
Buchanan, WW1
Blahosová, A1
Blahos, J2
Marsíková, L1
Bortz, WM1
Mincu, I1
Blétry, O1
Cartier, P1
Hamet, M1
Clauvel, JP1
Mosher, LR1
Isomäki, H1
Zucchelli, GP1
Felt, V2
Husek, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00005128]0 participants Observational1972-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for uric acid and Hypothyroidism

ArticleYear
[Hyperuricemia in endocrine disorders].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Bartter Syndrome; Diabetes Insipidus, Nephrogenic; Diabetes Insipidus, Neurogenic; Endocrine System

2003
Unusual manifestations of hypothyroidism.
    Archives of internal medicine, 1984, Volume: 144, Issue:1

    Topics: Adult; Anemia; Arthritis, Rheumatoid; Autoimmune Diseases; Cardiomegaly; Electromyography; Female; H

1984
[Associated and secondary chondrocalcinosis].
    Revue du rhumatisme et des maladies osteo-articulaires, 1977, Volume: 44, Issue:10

    Topics: Arthritis, Rheumatoid; Chondrocalcinosis; Chondroma; Diabetes Complications; Female; Gout; Hemochrom

1977
Early manifestations and investigation of cerebral arteriosclerosis.
    The Practitioner, 1976, Volume: 217, Issue:1297

    Topics: Angiography; Basilar Artery; Blood Glucose; Brain; Carotid Artery Diseases; Cerebrovascular Disorder

1976
The pathogenesis of hypercholesterolemia.
    Annals of internal medicine, 1974, Volume: 80, Issue:6

    Topics: Age Factors; Animals; Anxiety; Body Weight; Cholesterol; Diabetes Complications; Diet; Dietary Fats;

1974
Nicotinic acid side effects and toxicity: a review.
    The American journal of psychiatry, 1970, Volume: 126, Issue:9

    Topics: Adult; Age Factors; Animals; Anxiety; Arteriosclerosis; Carbohydrate Metabolism; Digestive System; D

1970

Trials

3 trials available for uric acid and Hypothyroidism

ArticleYear
Can levothyroxine treatment reduce urinary albumin excretion rate in patients with early type 2 diabetic nephropathy and subclinical hypothyroidism? A randomized double-blind and placebo-controlled study.
    Current medical research and opinion, 2015, Volume: 31, Issue:12

    Topics: Adult; Albumins; Autoantibodies; Cholesterol; Cholesterol, LDL; Diabetic Nephropathies; Double-Blind

2015
Postprandial lipemia as a risk factor for cardiovascular disease in patients with hypothyroidism.
    Endocrine, 2006, Volume: 29, Issue:3

    Topics: Blood Glucose; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Cholestero

2006
Prevalence of thyroid disease in an older Australian population.
    Internal medicine journal, 2007, Volume: 37, Issue:7

    Topics: Aged; Australia; Blood Glucose; Cross-Sectional Studies; Female; Humans; Hyperthyroidism; Hypothyroi

2007

Other Studies

31 other studies available for uric acid and Hypothyroidism

ArticleYear
Relation Between URIC Acid Levels and Subclinical Hypothyroidism in Diabetic Patients.
    Endocrine, metabolic & immune disorders drug targets, 2022, Volume: 22, Issue:5

    Topics: Cross-Sectional Studies; Diabetes Mellitus; Glycated Hemoglobin; Humans; Hypothyroidism; Uric Acid

2022
Longitudinal follow-up of patients with thalassaemia intermedia who started transfusion therapy in adulthood: a cohort study.
    British journal of haematology, 2020, Volume: 191, Issue:1

    Topics: Adolescent; Adult; Aged; beta-Thalassemia; Bilirubin; Blood Platelets; Blood Transfusion; Bone Disea

2020
Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity.
    Internal and emergency medicine, 2020, Volume: 15, Issue:1

    Topics: Adult; Aged; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Male; Middle Aged; Thyroid

2020
[Blood lipid, glucose and uric acid in people with subclinical hypothyroidism].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2013, Volume: 44, Issue:6

    Topics: Adult; Blood Glucose; Case-Control Studies; Female; Humans; Hypothyroidism; Lipids; Male; Mass Scree

2013
[Atypical risk factors of atherosclerosis in patients with hypothyroidism].
    Likars'ka sprava, 2013, Issue:6

    Topics: Adult; Aged; Atherosclerosis; Biomarkers; Body Mass Index; C-Reactive Protein; Carotid Arteries; Fem

2013
Association between serum free thyroxine (FT4) and uric acid levels in populations without overt thyroid dysfunction.
    Annals of clinical and laboratory science, 2015,Winter, Volume: 45, Issue:1

    Topics: Female; Humans; Hyperthyroidism; Hypothyroidism; Linear Models; Male; Middle Aged; Thyroid Gland; Th

2015
Gender impact on the correlations between subclinical thyroid dysfunction and hyperuricemia in Chinese.
    Clinical rheumatology, 2016, Volume: 35, Issue:1

    Topics: Adult; Aged; Asian People; China; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration

2016
[The Association Between Serum Uric Acid and Creatinine in Patients with Hypothyroidism].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2015, Volume: 46, Issue:5

    Topics: China; Creatinine; Female; Humans; Hypothyroidism; Male; Thyroid Function Tests; Thyrotropin; Thyrox

2015
Serum Total Sialic Acid Level is Elevated in Hypothyroid Patients as an Atherosclerotic Risk Factor.
    Journal of clinical laboratory analysis, 2017, Volume: 31, Issue:2

    Topics: Adolescent; Adult; Atherosclerosis; Autoantibodies; Biomarkers; C-Reactive Protein; Cardiovascular D

2017
An unusual patient with hypothyroidism, tophaceous gout, and marked joint destruction.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:6

    Topics: Aged; Gout; Humans; Hypothyroidism; Joints; Male; Uric Acid

2008
Methimazole and thyroid hormone replacement in broilers.
    Domestic animal endocrinology, 2003, Volume: 24, Issue:3

    Topics: Animals; Aspartate Aminotransferases; Chickens; Dietary Proteins; Hypothyroidism; Insulin-Like Growt

2003
Hyperuricemia in hypothyroidism: is it associated with post-insulin infusion glycemic response?
    The Tohoku journal of experimental medicine, 2003, Volume: 199, Issue:2

    Topics: Animals; Antithyroid Agents; Creatinine; Erythrocytes; Humans; Hyperuricemia; Hypothyroidism; Insuli

2003
[The hypothyroid rheumatic syndrome in the strict sense (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1980, Aug-01, Volume: 122, Issue:31

    Topics: Adult; Aged; Diabetes Complications; Female; Humans; Hypertension; Hypothyroidism; Male; Middle Aged

1980
[Thyroid and adrenal diagnosis in obesity are not worth while].
    Schweizerische medizinische Wochenschrift, 1983, Jan-08, Volume: 113, Issue:1

    Topics: Adult; Aged; Body Weight; Cushing Syndrome; Diabetes Complications; Female; Humans; Hyperlipidemias;

1983
[Excretion of phosphates and other substances in relation to changes in thyroid function].
    Vnitrni lekarstvi, 1982, Volume: 28, Issue:12

    Topics: Adult; Female; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged; Phosphates; Potassium; Sodium;

1982
Hyperuricemia in patients with hyperthyroidism due to Graves' disease.
    Metabolism: clinical and experimental, 1995, Volume: 44, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Female; Graves Disease; Humans; Hyperthyroidism; Hypothyroidism; Kid

1995
Lesch-Nyhan syndrome presenting with renal insufficiency in infancy and transient neonatal hypothyroidism.
    British journal of rheumatology, 1994, Volume: 33, Issue:4

    Topics: Acute Kidney Injury; Erythrocytes; Gout; Humans; Hypothyroidism; Hypoxanthine Phosphoribosyltransfer

1994
Reversible renal insufficiency, hyperuricemia and gouty arthritis in a case of hypothyroidism.
    Clinical nephrology, 1998, Volume: 49, Issue:1

    Topics: Adult; Arthritis, Gouty; Creatinine; Humans; Hypercholesterolemia; Hypothyroidism; Male; Renal Insuf

1998
Progressive nodular histiocytosis accompanied by systemic disorders.
    The British journal of dermatology, 2000, Volume: 143, Issue:3

    Topics: Cholesterol; Hepatomegaly; Histiocytosis, Non-Langerhans-Cell; Humans; Hypothyroidism; Leukemia, Mye

2000
Changes in serum thyrotropin (TSH) in man during halofenate administration.
    The Journal of clinical endocrinology and metabolism, 1976, Volume: 43, Issue:4

    Topics: Adult; Aged; Female; Glycolates; Halofenate; Humans; Hypothyroidism; Middle Aged; Serum Globulins; T

1976
[Cellulite].
    Medicina cutanea ibero-latino-americana, 1985, Volume: 13, Issue:6

    Topics: Adipose Tissue; Carbohydrate Metabolism; Cellulitis; Cholesterol; Female; Galactorrhea; Humans; Hype

1985
Alterations in clinical chemistry levels associated with the dyslipoproteinemias. The Lipid Research Clinics Program Prevalence Study.
    Circulation, 1986, Volume: 73, Issue:1 Pt 2

    Topics: Adult; Blood Glucose; Creatinine; Diabetes Mellitus; Dysgammaglobulinemia; Female; Humans; Hyperlipo

1986
Serum uric acid values in various states of thyroid function.
    Acta rheumatologica Scandinavica, 1966, Volume: 12, Issue:3

    Topics: Adult; Aged; Female; Goiter; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Thyroid Fun

1966
Effect of thyroid hormones on the end products of purine metabolism in the rat.
    Physiologia Bohemoslovaca, 1968, Volume: 17, Issue:1

    Topics: Allantoin; Animals; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Purines; Rats; Thyroid Hormon

1968
Some contributions to metabolic relationships of uric acid.
    Beitrage zur Rheumatologie, 1972, Volume: 18

    Topics: Cholesterol; Female; Gout; Humans; Hypothyroidism; Lactates; Male; Menopause; Sex Factors; Thyroid H

1972
[Hyperuricemia. (Etiopathogenic and therapeutic concepts)].
    Medicina interna, 1973, Volume: 25, Issue:2

    Topics: Diuretics; Gout; Humans; Hypertension; Hypothyroidism; Kidney Diseases; Nicotinic Acids; Nucleoprote

1973
[Hyperuricemia due to hypoxanthine-guanine-phosphoribosyltransferase deficiency].
    La Nouvelle presse medicale, 1974, Apr-20, Volume: 3, Issue:16

    Topics: Adult; Allopurinol; Anemia; Arthritis; Benzofurans; Gout; Humans; Hyperlipidemias; Hypothyroidism; H

1974
Hyperuricaemia in northern Finland. An epidemiological study of serum uric acid in rural, urban and hospital populations.
    Annals of clinical research, 1969, Volume: 1

    Topics: Adolescent; Adult; Age Factors; Aged; Anemia; Body Weight; Cerebrovascular Disorders; Cholesterol; C

1969
[Study on uric acid metabolism in hypothyroidism in old age].
    Giornale di gerontologia, 1967, Volume: 15, Issue:3

    Topics: Aged; Blood Urea Nitrogen; Female; Glomerular Filtration Rate; Humans; Hypothyroidism; Male; Myxedem

1967
[Nonesterified fatty acids after administration of human growth hormone in hyper-and hypothyroidism].
    Casopis lekaru ceskych, 1968, Volume: 107, Issue:38

    Topics: Blood Glucose; Fatty Acids, Nonesterified; Growth Hormone; Humans; Hyperthyroidism; Hypothyroidism;

1968
[Changes in the fatty acid composition in serum lipid fractions in patients with decreased, elevated and normal thyroid gland activity].
    Casopis lekaru ceskych, 1969, Volume: 108, Issue:29

    Topics: Blood Glucose; Carbon Isotopes; Cholesterol; Chromatography, Gas; Chromatography, Thin Layer; Fatty

1969