Page last updated: 2024-10-20

uric acid and Hypokalemia

uric acid has been researched along with Hypokalemia in 90 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12."9.06Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986)
" On arrival, laboratory test results were significant for hypokalemia, hyperchloremic metabolic acidosis, low uric acid concentration, positive urine anion gap, and proteinuria, which resolved on discontinuation of the drug."7.85Proximal Renal Tubular Acidosis (Fanconi Syndrome) Induced by Apremilast: A Case Report. ( Afridi, F; Kar, P; King-Morris, K; Komarla, A; Perrone, D, 2017)
"A Thai female patient developed muscular weakness, hypouricemia, hypokalemia and hyperchloremic metabolic acidosis after taking outdated tetracycline."7.69Hypouricemia, hypokalemia, proximal and distal tubular acidification defect following administration of outdated tetracycline: a case report. ( Chusil, S; Pansin, P; Tungsanga, K; Wathanavaha, A, 1994)
"Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage."6.65Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983)
"One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12."5.06Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986)
"Men and women with isolated systolic hypertension who were at least 60 years of age were treated for 1 year with chlorthalidone (25-50 mg daily) or matching placebo as the step I drug."5.06Use of diuretics in treatment of hypertension in the elderly. ( Feigal, DW; Furberg, CD; Greenlick, M; Kuller, L; Perry, HM; Schnaper, HW; Schoenberger, JA; Smith, WM, 1986)
" On arrival, laboratory test results were significant for hypokalemia, hyperchloremic metabolic acidosis, low uric acid concentration, positive urine anion gap, and proteinuria, which resolved on discontinuation of the drug."3.85Proximal Renal Tubular Acidosis (Fanconi Syndrome) Induced by Apremilast: A Case Report. ( Afridi, F; Kar, P; King-Morris, K; Komarla, A; Perrone, D, 2017)
"Trichlormethiazide, a thiazide diuretic, was introduced in 1960 and remains one of the most frequently used diuretics for treating hypertension in Japan."3.77Adverse effect profile of trichlormethiazide: a retrospective observational study. ( Asai, S; Nakayama, T; Nishida, Y; Takahashi, Y, 2011)
" Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance."3.74Thiazide diuretics exacerbate fructose-induced metabolic syndrome. ( Johnson, RJ; Mu, W; Nakagawa, T; Reungjui, S; Roncal, CA; Sirivongs, D; Srinivas, TR, 2007)
"A Thai female patient developed muscular weakness, hypouricemia, hypokalemia and hyperchloremic metabolic acidosis after taking outdated tetracycline."3.69Hypouricemia, hypokalemia, proximal and distal tubular acidification defect following administration of outdated tetracycline: a case report. ( Chusil, S; Pansin, P; Tungsanga, K; Wathanavaha, A, 1994)
"Interstitial nephritis consequent to rifampin was associated with potassium wasting, an acidifying defect, high fractional uric acid excretion, and glucosuria, indicating a multiplicity of renal tubular transport abnormalities."3.67Potassium wasting and other renal tubular defects with rifampin nephrotoxicity. ( Cheng, JT; Kahn, T, 1984)
"Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage."2.65Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983)
"Diuretics have long been used in the treatment of hypertension and are outstandingly efficacious when used either alone or in combination with other antihypertensive compounds."2.38Diuretics in hypertension: clinical experiences. ( Papademetriou, V, 1992)
" This increased potency and the consequent decreased dose requirement give bumetanide the potential for increased effectiveness and decreased incidence of adverse effects."2.37Cellular mechanism of action of loop diuretics: implications for drug effectiveness and adverse effects. ( Feig, PU, 1986)
"In patients with cancer, tumor bulk and invasion of vital organs do not always explain the clinical deterioration and cause of death."2.36Renal manifestations of extrarenal neoplasms. ( Pascal, RR, 1980)
"Individuals with cancer are subject to fluid and electrolyte imbalances because of the original disease process, therapy, and complications resulting from both the disease process and from therapy."2.36Fluid and electrolyte disturbances associated with cancer and its treatment. ( Cunningham, SG, 1982)
"Hyperkalemia is produced by redistribution of cellular and extracellular potassium or by increased body potassium."2.36Diagnostic strategies in disorders of fluid, electrolyte and acid-base homeostasis. ( Bastl, CP; Jones, ER; Narins, RG; Rudnick, MR; Stom, MC, 1982)
"Primary distal renal tubular acidosis (dRTA) is an inherited disease characterized by the inability of the distal tubule to lower urine pH <5."1.35Atypical presentation of distal renal tubular acidosis in two siblings. ( Blau, N; Cheong, HI; Gucev, Z; Hoppe, B; Korneti, P; Tasic, V, 2008)
"In two patients with Bartter's syndrome proximal tubular function and distal chloride reabsorption were intact on admission; however, chloride reabsorption and distal tubular acidifying capacity decreased in one patient over a period of 10 years."1.29Ammonium urate nephrolithiasis in a variant of Bartter's syndrome with intact renal tubular function. ( Ishii, M; Maio, A; Shioniri, H; Umemura, S; Yasuda, G; Zierer, R, 1994)
" Nevertheless, in view of the potential seriousness of volume depletion, dosage should probably begin at 20 rather than 40 mg daily."1.26Adverse reactions to frusemide in hospital inpatients. ( Gray, J; Henry, DA; Lawson, DH; Lowe, J, 1979)
" Their long term use alone provides smooth control of blood pressure in mild to moderate hypertensives (Beevers, Hamilton and Harpur, 1971), and they are also valuable as adjuvant therapy with other antihypertensive drugs."1.26The effect of thiazide diuretics on coronary risk factors. ( Beevers, DG; Bloxham, CA, 1979)
"Uric acid was increased 38 and 48% over the control values by doses of 4."1.25Nephrotoxicity of dietary ochratoxin A in broiler chickens. ( Hamilton, PB; Huff, WE; Wyatt, RD, 1975)

Research

Studies (90)

TimeframeStudies, this research(%)All Research%
pre-199076 (84.44)18.7374
1990's6 (6.67)18.2507
2000's6 (6.67)29.6817
2010's2 (2.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Perrone, D1
Afridi, F1
King-Morris, K1
Komarla, A1
Kar, P1
Takahashi, Y1
Nishida, Y1
Nakayama, T1
Asai, S1
WILSON, CP1
DAVISON, KS1
FREI, E1
BENTZEL, CJ1
RIESELBACH, R1
BLOCK, JB1
BODA, D1
LYON, AF1
DEGRAFF, AC2
SPERBER, RJ1
FISCH, S1
FREUDENTHAL, RR1
MAVROMATIS, F1
Reungjui, S1
Roncal, CA1
Mu, W1
Srinivas, TR1
Sirivongs, D1
Johnson, RJ1
Nakagawa, T1
Tasic, V1
Korneti, P1
Gucev, Z1
Hoppe, B1
Blau, N1
Cheong, HI1
Losse, H2
Kayser, D1
Morledge, JH2
Kojima, S1
Ito, K1
Ikeda, M1
Pascal, RR1
Cheng, JT1
Kahn, T1
Ogilvie, RI1
Cunningham, SG1
Smith, WE1
Steele, TH1
Zumkley, H1
Quante, T1
Perry, HM2
Narins, RG1
Jones, ER1
Stom, MC1
Rudnick, MR1
Bastl, CP1
Holzgreve, H1
Morgan, T1
Myers, J1
Dupont, P1
Ducobu, J1
Schreiber, S1
Lombardo, JV1
Terlinsky, A1
Chester, AC1
Preuss, HG1
Shapiro, AP1
Traub, YM1
Chusil, S1
Tungsanga, K1
Wathanavaha, A1
Pansin, P1
Tomino, Y1
Mizoguchi, M1
Yasuda, G1
Zierer, R1
Maio, A1
Shioniri, H1
Ishii, M1
Umemura, S1
Donati-Genet, P1
Donati, R1
Colombo, JP1
Lüthy, CM1
Bianchetti, MG1
Liamis, G2
Elisaf, M2
Palamarchuk, MI1
Kozlovskaia, LV1
Balkarov, IM1
Carducci, MA1
Gilbert, J1
Bowling, MK1
Noe, D1
Eisenberger, MA1
Sinibaldi, V1
Zabelina, Y1
Chen, TL1
Grochow, LB1
Donehower, RC1
Rizos, E1
Finnerty, FA1
Knochel, JP2
Carter, NW1
Lowe, J1
Gray, J1
Henry, DA1
Lawson, DH1
Bloxham, CA1
Beevers, DG2
Carlier, J1
Rorive, G1
Bovy, P1
Cannon, ML1
Tannenbaum, RP1
La Franco, M1
Hollifield, JW1
Bogusky, RT1
Lowenstein, LM1
Lowenstein, JM1
Hirschel, B1
Huff, WE1
Wyatt, RD1
Hamilton, PB1
Mach, RS1
Glezer, GA1
Papademetriou, V1
Moser, M4
Feig, PU1
Ettinger, B1
Aranda, J1
McBarron, F1
Barra, P1
Gorwit, J1
Davidov, M1
Black, H1
Stair, D1
Field, MJ1
Lawrence, JR1
Smith, WM1
Feigal, DW1
Furberg, CD1
Greenlick, M1
Kuller, L1
Schnaper, HW1
Schoenberger, JA1
Pupita, F1
Campolucci, G1
Pulido, M1
Belogi, M1
Rotatori, P1
Ansuini, R1
Frausini, G1
Barone, A1
Gaggi, S1
Puschett, JB1
Chrysant, SG1
Frohlich, ED1
Jelliffe, RW1
Hill, D1
Tatter, D1
Lewis, E1
Förster, H1
Heller, L1
Hellmund, U1
Burmeister, H1
Ohlmeier, H1
Baethke, R1
Pentikäinen, P1
Jahnecke, J1
Furukawa, T1
Kirkendall, WM1
Azer, M1
Munro, JF1
Duncan, LJ1
Kramer, HJ1
Krück, F1
MacFarlane, JP1
Kennedy, RD1
Ben-Ishay, D1
Levy, M1
Birnbaum, D1
Burgess, JL1
Birchall, R2
Martinez-Maldonado, M1
Dustan, HR1
Tarazi, RC1
Bravo, EL1
Freis, ED1
Miyahara, M1
Fujise, Y1
Hoshikawa, K1
Nakagawa, K1
Leiter, L1
Anderton, JL1
Kincaid-Smith, P1
Burges, JL1
Jachuck, SJ1
Antcliff, AC1
Hamilton, M1
Harpur, JE1
Muggia, FM1
Heinemann, HO1
Farhangi, M1
Osserman, EF1
Werning, C1
Siegenthaler, W1
Lant, AF1
Wilson, GM1
Rastogi, SP1
Volans, G1
Elliott, RW1
Eccleston, DW1
Ashcroft, R1
Webster, D1
Kerr, DN1
Berlind, S1
Lundvall, O1
Shear, L1
Bonkowsky, HL1
Gabuzda, GJ1
Lawlor, T1
Wells, DG1
Remenchik, AP1
Johnston, LC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Uric Acid and Hypertension in African Americans[NCT00241839]Phase 3150 participants (Actual)Interventional2005-08-31Completed
Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761]Phase 4471 participants (Actual)Interventional2018-02-13Completed
Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia[NCT04744987]122 participants (Actual)Observational2019-07-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure by Cuff 8-10 Weeks Minus Baseline

"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo

Interventionmm Hg (Mean)
A (Allopurinol)3.44
B (Placebo)-0.83

Change in Overall Mean BP From Those Obtained by 24 Hour Ambulatory Blood Pressure Measurements (ABPM) 8-10 Weeks Minus Baseline.

Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)

Interventionmm Hg (Mean)
A (Allopurinol)-5.9
B (Placebo)0.90

Change in Systolic Blood Pressure by Cuff After 8-10 Weeks Minus Baseline

"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo

Interventionmm Hg (Mean)
A (Allopurinol)0.21
B (Placebo)-0.95

Change in Uric Acid (UA) Levels: Baseline Less End of Treatment

Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)

Interventionmg/dl (Mean)
A (Allopurinol)2.29
B (Placebo)0.14

Reviews

21 reviews available for uric acid and Hypokalemia

ArticleYear
RENAL COMPLICATIONS OF NEOPLASTIC DISEASE.
    Journal of chronic diseases, 1963, Volume: 16

    Topics: Antineoplastic Agents; Bence Jones Protein; Hemorrhage; Humans; Hypercalcemia; Hypokalemia; Hyponatr

1963
[Mild hypertension and the role of diuretics].
    Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:9

    Topics: Diuretics; Drug Evaluation; Humans; Hypertension; Hypokalemia; Uric Acid

1984
Renal manifestations of extrarenal neoplasms.
    Human pathology, 1980, Volume: 11, Issue:1

    Topics: Amyloidosis; Antineoplastic Agents; Disseminated Intravascular Coagulation; Humans; Hypokalemia; Imm

1980
Fluid and electrolyte disturbances associated with cancer and its treatment.
    The Nursing clinics of North America, 1982, Volume: 17, Issue:4

    Topics: Blood Volume; Body Water; Calcium; Humans; Hypercalcemia; Hyperkalemia; Hypocalcemia; Hypokalemia; I

1982
Diagnostic strategies in disorders of fluid, electrolyte and acid-base homeostasis.
    The American journal of medicine, 1982, Volume: 72, Issue:3

    Topics: Acid-Base Imbalance; Acidosis; Alkalosis; Bicarbonates; Calcium Metabolism Disorders; Humans; Hyperk

1982
[Kidney diseases caused by hypercalcemia, hyperuricemia, hyperoxaluria and hypokalemia].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1994, Oct-10, Volume: 83, Issue:10

    Topics: Humans; Hypercalcemia; Hyperoxaluria; Hypokalemia; Kidney; Kidney Diseases; Uric Acid

1994
Renal injury in mu.
    Perspectives in nephrology and hypertension, 1976, Volume: 3

    Topics: Acute Kidney Injury; Adult; Animals; Glomerular Filtration Rate; Hemodynamics; Humans; Hypokalemia;

1976
Diuretics in hypertension: clinical experiences.
    European heart journal, 1992, Volume: 13 Suppl G

    Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Diuretics; Humans; Hypertension; Hypokalemia; Risk F

1992
Cellular mechanism of action of loop diuretics: implications for drug effectiveness and adverse effects.
    The American journal of cardiology, 1986, Jan-24, Volume: 57, Issue:2

    Topics: Animals; Chlorides; Diuretics; Dose-Response Relationship, Drug; Drug Resistance; Erythrocyte Membra

1986
The dilemma of mild hypertension.
    Drugs, 1986, Volume: 31, Issue:4

    Topics: Arrhythmias, Cardiac; Blood Glucose; Clinical Trials as Topic; Diuretics; Humans; Hypertension; Hypo

1986
Complications of thiazide diuretic therapy: an update.
    The Medical journal of Australia, 1986, Jun-09, Volume: 144, Issue:12

    Topics: Alkalosis; Benzothiadiazines; Blood Volume; Coronary Disease; Death, Sudden; Diuretics; Drug Hyperse

1986
The diuretic dilemma and the management of mild hypertension.
    Drugs, 1986, Volume: 31 Suppl 4

    Topics: Arrhythmias, Cardiac; Blood Glucose; Cholesterol; Diuretics; Humans; Hypertension; Hypokalemia; Uric

1986
The diuretic dilemma and the management of mild hypertension.
    Journal of clinical hypertension, 1986, Volume: 2, Issue:2

    Topics: Arrhythmias, Cardiac; Decision Making; Diuretics; Drug Therapy, Combination; Glucose; Humans; Hypert

1986
[Metabolic effects of diuretics].
    Duodecim; laaketieteellinen aikakauskirja, 1974, Volume: 90, Issue:14

    Topics: Angiotensin II; Depression, Chemical; Diuretics; Glucose; Gout; Humans; Hypokalemia; Magnesium; Pota

1974
Diuretics and hypertension.
    Journal of the Iowa Medical Society, 1972, Volume: 62, Issue:1

    Topics: Azides; Benzothiadiazines; Blood Vessels; Diuretics; Extracellular Space; Humans; Hyperglycemia; Hyp

1972
Fasting in the treatment of obesity.
    The Practitioner, 1972, Volume: 208, Issue:246

    Topics: Adolescent; Body Weight; Diet, Reducing; Fasting; Hospitalization; Humans; Hypokalemia; Middle Aged;

1972
[Pharmacological bases of diuretic therapy. 2].
    Medizinische Klinik, 1974, Jan-18, Volume: 69, Issue:3

    Topics: Acidosis; Alkalosis; Digitalis Glycosides; Diuretics; Drug Synergism; Edema; Gastrointestinal Hemorr

1974
Antihypertensive action of benzothiadiazines.
    New York state journal of medicine, 1968, Jan-15, Volume: 68, Issue:2

    Topics: Benzothiadiazines; Chlorothiazide; Guanethidine; Humans; Hyperglycemia; Hypertension; Hypokalemia; M

1968
[Effects and side-effects of hypotensive diuretics].
    Nihon rinsho. Japanese journal of clinical medicine, 1968, Volume: 26, Issue:7

    Topics: Antihypertensive Agents; Benzothiadiazines; Chlorothiazide; Diabetes Mellitus; Diuretics; Gout; Huma

1968
Combinations of diuretics in the treatment of edema.
    American heart journal, 1970, Volume: 80, Issue:3

    Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu

1970
Diuretics. II. Clinical considerations.
    Drugs, 1971, Volume: 1, Issue:2

    Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I

1971

Trials

12 trials available for uric acid and Hypokalemia

ArticleYear
[Short and long term treatment of cardiac edemas with ethacrynic acid].
    Deutsche medizinische Wochenschrift (1946), 1967, May-05, Volume: 92, Issue:18

    Topics: Adult; Aged; Blood Pressure; Diuresis; Ethacrynic Acid; Female; Heart Failure; Humans; Hypokalemia;

1967
Clinical efficacy and safety of indapamide in essential hypertension.
    American heart journal, 1983, Volume: 106, Issue:1 Pt 2

    Topics: Adult; Aged; Animals; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electrolytes; Humans

1983
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Disorders of Excessive Somnolenc

2001
In defense of traditional antihypertensive therapy.
    Hypertension (Dallas, Tex. : 1979), 1988, Volume: 12, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors;

1988
Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone.
    Journal of the American Geriatrics Society, 1986, Volume: 34, Issue:3

    Topics: Age Factors; Aged; Blood Glucose; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic

1986
The dilemma of mild hypertension.
    Drugs, 1986, Volume: 31, Issue:4

    Topics: Arrhythmias, Cardiac; Blood Glucose; Clinical Trials as Topic; Diuretics; Humans; Hypertension; Hypo

1986
Use of diuretics in treatment of hypertension in the elderly.
    Drugs, 1986, Volume: 31 Suppl 4

    Topics: Aged; Chlorthalidone; Creatinine; Double-Blind Method; Female; Humans; Hypertension; Hypokalemia; Ma

1986
[Metabolic investigations during continuous infusion of glucose, fructose, and xylitol over 48 hours (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Aug-30, Volume: 99, Issue:35

    Topics: Adult; Aspartate Aminotransferases; Clinical Enzyme Tests; Fatty Acids; Fructose; Glucose; Humans; H

1974
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.
    Circulation, 1972, Volume: 45, Issue:5

    Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu

1972
The effects of amiloride during diuretic therapy in elderly subjects.
    Age and ageing, 1972, Volume: 1, Issue:2

    Topics: Administration, Oral; Aged; Amiloride; Calcium; Clinical Trials as Topic; Diuretics; Drug Combinatio

1972
Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels.
    The British journal of clinical practice, 1972, Volume: 26, Issue:9

    Topics: Alanine Transaminase; Amiloride; Aspartate Aminotransferases; Diuretics; Drug Combinations; Humans;

1972
Long-term therapy of diabetes insipidus with oral benzothiadiazine and phthalimidine diuretics.
    Clinical science, 1971, Volume: 40, Issue:6

    Topics: Administration, Oral; Adult; Antihypertensive Agents; Benzothiadiazines; Blood Glucose; Child; Diabe

1971

Other Studies

58 other studies available for uric acid and Hypokalemia

ArticleYear
Proximal Renal Tubular Acidosis (Fanconi Syndrome) Induced by Apremilast: A Case Report.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017, Volume: 70, Issue:5

    Topics: Acidosis; Acidosis, Renal Tubular; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriat

2017
Adverse effect profile of trichlormethiazide: a retrospective observational study.
    Cardiovascular diabetology, 2011, May-23, Volume: 10

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Biomarkers; Blood Urea Nitrogen; Chi-Square Distri

2011
Thiazide hypopotassemia and hyperuricemia.
    Northwest medicine, 1961, Volume: 60

    Topics: Chlorothiazide; Humans; Hyperuricemia; Hypokalemia; Potassium; Thiazides; Uric Acid

1961
[DISEASES OF THE INTRACELLULAR SYSTEM IN THE COURSE OF ACUTE METABOLIC DISTURBANCES].
    Orvosi hetilap, 1964, Feb-23, Volume: 105

    Topics: Blood Chemical Analysis; Cell Biology; Hypernatremia; Hypokalemia; Metabolic Diseases; Nitrogen; Sep

1964
DIURETIC THERAPY. VI. METABOLIC COMPLICATIONS OF THIAZIDE THERAPY AND THEIR CORRECTION.
    American heart journal, 1964, Volume: 68

    Topics: Bendroflumethiazide; Blood; Blood Urea Nitrogen; Diuretics; Humans; Hydrochlorothiazide; Hyperglycem

1964
CORRECTION OF DIURETIC-INDUCED HYPOKALEMIA AND HYPERURICEMIA.
    The American journal of the medical sciences, 1965, Volume: 249

    Topics: Bicarbonates; Blood Chemical Analysis; Chlorthalidone; Diuretics; Drug Therapy; Geriatrics; Hydrochl

1965
TETRACYCLINE NEPHROPATHY; CASE REPORT WITH RENAL BIOPSY.
    JAMA, 1965, Jul-19, Volume: 193

    Topics: Acidosis; Acidosis, Renal Tubular; Ataxia; Biopsy; Blood; Chemistry, Pharmaceutical; Glycosuria; Gly

1965
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:10

    Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Diuretics; Fructose; Gout Suppressants; Hydrochlo

2007
Atypical presentation of distal renal tubular acidosis in two siblings.
    Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:7

    Topics: Acidosis, Renal Tubular; Child, Preschool; Chlorides; Growth Disorders; Hearing Loss, Sensorineural;

2008
[Saluresis in the treatment of hypertension].
    Munchener medizinische Wochenschrift (1950), 1966, Dec-23, Volume: 108, Issue:51

    Topics: Carbohydrate Metabolism; Diet, Sodium-Restricted; Diuretics; Humans; Hypertension; Hypokalemia; Pota

1966
Potassium wasting and other renal tubular defects with rifampin nephrotoxicity.
    American journal of nephrology, 1984, Volume: 4, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Humans; Hypokalemia; Kidney Tubules; Male; Nephritis, Interstitial; Po

1984
Diuretic treatment in essential hypertension.
    Current medical research and opinion, 1983, Volume: 8 Suppl 3

    Topics: Aged; Arrhythmias, Cardiac; Blood Glucose; Diuretics; Dose-Response Relationship, Drug; Hemodynamics

1983
Avoiding diuretic-related complications in older patients.
    Geriatrics, 1983, Volume: 38, Issue:2

    Topics: Aged; Blood Volume; Diuretics; Glucose; Humans; Hypokalemia; Hyponatremia; Uric Acid

1983
Side effects of diuretics.
    Clinical and experimental hypertension. Part A, Theory and practice, 1983, Volume: 5, Issue:2

    Topics: Calcium; Carbohydrate Metabolism; Diuretics; Drug Interactions; Humans; Hypokalemia; Lipid Metabolis

1983
Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents.
    American heart journal, 1983, Volume: 106, Issue:1 Pt 2

    Topics: Adult; Antihypertensive Agents; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Humans; Hy

1983
[Therapy of cardiac insufficiency with diuretics].
    Fortschritte der Medizin, 1982, Aug-26, Volume: 100, Issue:31-32

    Topics: Amiloride; Benzothiadiazines; Blood Glucose; Diuretics; Drug Administration Schedule; Female; Furose

1982
The use of diuretics in hypertension.
    Australian family physician, 1982, Volume: 11, Issue:8

    Topics: Benzothiadiazines; Carbohydrate Metabolism; Diuretics; Dose-Response Relationship, Drug; Humans; Hyp

1982
[Long-term side-effects of diuretics in the treatment of hypertension (author's transl)].
    La Nouvelle presse medicale, 1981, Mar-28, Volume: 10, Issue:14

    Topics: Blood Glucose; Diuretics; Humans; Hypertension; Hypokalemia; Potassium; Retrospective Studies; Trigl

1981
Tubulointerstitial diseases.
    American family physician, 1980, Volume: 21, Issue:1

    Topics: Analgesics; Drug Hypersensitivity; Glomerular Filtration Rate; Humans; Hypercalcemia; Hypokalemia; I

1980
Complications of antihypertensive therapy.
    American family physician, 1981, Volume: 23, Issue:3

    Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydr

1981
Hypouricemia, hypokalemia, proximal and distal tubular acidification defect following administration of outdated tetracycline: a case report.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1994, Volume: 77, Issue:2

    Topics: Acidosis, Renal Tubular; Adult; Female; Humans; Hypokalemia; Tetracycline; Uric Acid

1994
Ammonium urate nephrolithiasis in a variant of Bartter's syndrome with intact renal tubular function.
    The Clinical investigator, 1994, Volume: 72, Issue:5

    Topics: Adult; Bartter Syndrome; Chlorides; Female; Humans; Hypokalemia; Kidney Calculi; Kidney Function Tes

1994
Urinary sodium, potassium, chloride, calcium, magnesium, phosphate, urate and urea in healthy subjects aged 5-18 years.
    Nephron, 1998, Volume: 78, Issue:2

    Topics: Acidosis, Renal Tubular; Adolescent; Calcium; Child; Child, Preschool; Chlorides; Electrolytes; Fema

1998
Hypokalemia, hypophosphatemia and hypouricemia due to proximal renal tubular dysfunction in acute myeloid leukemia.
    European journal of haematology, 2000, Volume: 64, Issue:4

    Topics: Acute Disease; Aged; Female; Humans; Hypokalemia; Hypophosphatemia; Kidney Tubules, Proximal; Leukem

2000
[Bartter's syndrome with hyperuricemia].
    Terapevticheskii arkhiv, 2001, Volume: 73, Issue:2

    Topics: Adult; Aldosterone; Bartter Syndrome; Child; Female; Humans; Hypokalemia; Kidney Failure, Chronic; P

2001
Multiple metabolic abnormalities in a patient with the syndrome of inappropriate antidiuresis.
    Nephron, 2002, Volume: 91, Issue:2

    Topics: Blood Volume; Female; Humans; Hypokalemia; Hyponatremia; Inappropriate ADH Syndrome; Magnesium; Midd

2002
Diuretics as initial treatment for essential hypertension.
    British journal of clinical pharmacology, 1979, Volume: 7 Suppl 2

    Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Humans; Hyperg

1979
The role of muscle cell injury in the pathogenesis of acute renal failure after exercise.
    Kidney international. Supplement, 1976, Volume: 6

    Topics: Acute Kidney Injury; Adenosine Triphosphatases; Aldosterone; Animals; Creatine Kinase; Dogs; Hot Tem

1976
Adverse reactions to frusemide in hospital inpatients.
    British medical journal, 1979, Aug-11, Volume: 2, Issue:6186

    Topics: Aged; Drug Administration Schedule; Female; Furosemide; Hospitalization; Humans; Hypokalemia; Male;

1979
The effect of thiazide diuretics on coronary risk factors.
    Postgraduate medical journal, 1979, Volume: 55 Suppl 3

    Topics: Aged; Benzothiadiazines; Blood Glucose; Coronary Disease; Diuretics; Female; Hematocrit; Humans; Hyp

1979
[Diuretics in cardiac insufficiency].
    Acta clinica Belgica, 1977, Volume: 32, Issue:3

    Topics: Alkalosis; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Diuretics; Diuretics, Osmotic; Heart Fa

1977
Diuretics in the treatment of hypertension.
    American pharmacy, 1978, Volume: 18, Issue:5

    Topics: Benzothiadiazines; Diuretics; Humans; Hyperglycemia; Hypertension; Hypokalemia; Sodium Chloride Symp

1978
Biochemical consequences of diuretic therapy in hypertension.
    Journal of the Tennessee Medical Association, 1978, Volume: 71, Issue:10

    Topics: Benzothiadiazines; Diuretics; Humans; Hypercalcemia; Hyperglycemia; Hypertension; Hypokalemia; Sodiu

1978
The purine nucleotide cycle. A pathway for ammonia production in the rat kidney.
    The Journal of clinical investigation, 1976, Volume: 58, Issue:2

    Topics: Adenine Nucleotides; Allopurinol; Ammonia; Ammonium Chloride; AMP Deaminase; Animals; Aspartic Acid;

1976
[Dr. Atkins' dietetic revolution: a critique].
    Schweizerische medizinische Wochenschrift, 1977, Jul-23, Volume: 107, Issue:29

    Topics: Acidosis; Adult; Cholesterol; Diet, Reducing; Dietary Carbohydrates; Dietary Fats; Energy Intake; Hu

1977
Nephrotoxicity of dietary ochratoxin A in broiler chickens.
    Applied microbiology, 1975, Volume: 30, Issue:1

    Topics: Animal Feed; Animals; Chickens; Hypokalemia; Kidney Diseases; Kidney Function Tests; Male; Ochratoxi

1975
[Editorial: Edema from diuretics abuse].
    Schweizerische medizinische Wochenschrift, 1976, Feb-07, Volume: 106, Issue:6

    Topics: Adult; Diuretics; Edema; Female; Humans; Hyperaldosteronism; Hyperglycemia; Hypokalemia; Hyponatremi

1976
[The side effects and complications in treatment with diuretic preparations. 2].
    Terapevticheskii arkhiv, 1992, Volume: 64, Issue:11

    Topics: Diuretics; Drug Hypersensitivity; Humans; Hypercalcemia; Hyperkalemia; Hypocalcemia; Hypokalemia; Ma

1992
[Negative effects of diuretics].
    La Clinica terapeutica, 1985, Oct-15, Volume: 115, Issue:1

    Topics: Alkalosis; Diuretics; Heart Diseases; Humans; Hyperglycemia; Hypokalemia; Hyponatremia; Insulin; Liv

1985
Diuretic therapy update.
    Comprehensive therapy, 1985, Volume: 11, Issue:10

    Topics: Acid-Base Imbalance; Acute Kidney Injury; Diet, Sodium-Restricted; Diuretics; Ear Diseases; Heart Fa

1985
Side effects of antihypertensive drugs.
    American family physician, 1974, Volume: 9, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazine

1974
Death from weight-control pills. A case report with objective postmortem confirmation.
    JAMA, 1969, Jun-09, Volume: 208, Issue:10

    Topics: Adult; Amphetamine; Appetite Depressants; Arrhythmias, Cardiac; Death, Sudden; Digitalis Glycosides;

1969
[Side effects and complication possibilities following high-dosage furosemide treatment].
    Medizinische Klinik, 1972, Oct-27, Volume: 67, Issue:43

    Topics: Adult; Aged; Alkalosis; Blood Coagulation Disorders; Blood Glucose; Dehydration; Drug Eruptions; Ear

1972
[Side effects of antihypertensive agents].
    Medizinische Klinik, 1970, Dec-11, Volume: 65, Issue:50

    Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Diarrhea; Diuretics; Fatigue; Ganglionic Blockers; Ga

1970
[Side effects of diuretics].
    Nihon Jinzo Gakkai shi, 1974, Volume: 16, Issue:5

    Topics: Adolescent; Adult; Aged; Benzothiadiazines; Child; Diuretics; Female; Furosemide; Humans; Hypokalemi

1974
Self-induced secondary hyperaldosteronism simulating Bartter's syndrome.
    Israel journal of medical sciences, 1972, Volume: 8, Issue:11

    Topics: Adult; Alkalosis; Diagnosis, Differential; Female; Furosemide; Humans; Hyperaldosteronism; Hypertrop

1972
Nephrotoxicity of amphotericin B, with emphasis on changes in tubular function.
    The American journal of medicine, 1972, Volume: 53, Issue:1

    Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Amphotericin B; Blastomycosis; Carbon Dioxide; Glome

1972
Electrolyte disturbances resulting from diuretic therapy.
    Texas medicine, 1973, Volume: 69, Issue:7

    Topics: Acetazolamide; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypercalcemia; Hypokalemia; Hyponatre

1973
Diuretic and diet treatment of hypertension.
    Archives of internal medicine, 1974, Volume: 133, Issue:6

    Topics: Benzothiadiazines; Blood Volume; Chlorthalidone; Creatinine; Diet, Sodium-Restricted; Diuretics; Eth

1974
Nephrotoxicity of amphotericin B, with emphasis on changes in tubular function.
    The American journal of medicine, 1972, Volume: 53, Issue:1

    Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Amphotericin B; Blastomycosis; Carbon Dioxide; Glome

1972
Trial of mefruside.
    British medical journal, 1972, Sep-02, Volume: 3, Issue:5826

    Topics: Diuretics; Humans; Hypertension; Hypokalemia; Sulfonic Acids; Uric Acid

1972
Lysozymuria and renal tubular dysfunction in monocytic and myelomonocytic leukemia.
    The American journal of medicine, 1969, Volume: 47, Issue:3

    Topics: Acidosis, Renal Tubular; Adult; Aged; Ammonia; Calcium; Chlorides; Creatinine; Female; Humans; Hydro

1969
[Guidelines for therapy with diuretics].
    Deutsche medizinische Wochenschrift (1946), 1970, Mar-06, Volume: 95, Issue:10

    Topics: Alkalosis; Carbohydrate Metabolism; Diuretics; Drug Synergism; Glaucoma; Humans; Hypertension; Hypok

1970
High dose frusemide in the treatment of hypertension in chronic renal insufficiency and of terminal renal failure.
    Postgraduate medical journal, 1971, Volume: 47

    Topics: Adolescent; Adult; Creatine; Creatinine; Diuresis; Female; Furosemide; Gout; Humans; Hypertension, R

1971
Serum electrolyte changes during ling-term treatment with amiloride hydrochloride (MK-870).
    Acta medica Scandinavica, 1968, Volume: 183, Issue:4

    Topics: Adult; Aged; Blood Gas Analysis; Body Weight; Carbon Dioxide; Chlorides; Creatinine; Digitalis Glyco

1968
Renal tubular acidosis in cirrhosis. A determinant of susceptibility to recurrent hepatic precoma.
    The New England journal of medicine, 1969, Jan-02, Volume: 280, Issue:1

    Topics: Acidosis, Renal Tubular; Ammonia; Ammonium Chloride; Blood Urea Nitrogen; Calcium; Calcium Chloride;

1969
Metabolic hazards of fasting.
    The American journal of clinical nutrition, 1969, Volume: 22, Issue:8

    Topics: Adult; Anemia; Autoanalysis; Blood Cell Count; Blood Proteins; Blood Urea Nitrogen; Body Weight; Chl

1969
Potassium depletion produced by administration of chlorthalidone to nonedematous patients with arterial hypertensin.
    The American journal of the medical sciences, 1966, Volume: 252, Issue:2

    Topics: Adult; Alkalosis; Blood Urea Nitrogen; Carbon Dioxide; Chlorine; Chlorthalidone; Creatine; Female; H

1966