uric acid has been researched along with Hypertension in 1913 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gender-based evidence on the association between serum uric acid (SUA) and left ventricular hypertrophy (LVH), as assessed by echocardiography, is still based on single studies." | 9.94 | Uric acid and left ventricular hypertrophy: a gender-based meta-analysis of echocardiographic studies. ( Carugo, S; Cuspidi, C; Faggiano, A; Gherbesi, E; Grassi, G; Sala, C; Tadic, M, 2024) |
| " Obesity, lipids, glucose tolerance and insulin resistance are risk factors for numerous cardiovascular diseases and are often accompanied by a considerable increase in serum uric acid (SUA) concentrations." | 9.94 | Insights into the relationship between serum uric acid and pulmonary hypertension (Review). ( Chen, M; He, Y; Lei, W; Luo, H; Shui, X; Zheng, J; Zhou, Y, 2024) |
| "Our study demonstrated the efficiency of benzbromarone in hypertensive patients with concomitant asymptomatic hyperuricemia, including the benefits on ameliorating LV diastolic dysfunction as well as improving composite endpoints." | 9.69 | Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function. ( Gu, J; Han, Z; Ke, J; Lin, H; Pan, J, 2023) |
| "The study showed that in patients with hypertension and metabolic syndrome, both losartan and eprosartan have a neutral effect on fasting and postfructose load serum uric acid concentration and its urinary excretion." | 9.41 | Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome. ( Majer, J; Masajtis-Zagajewska, A; Nowicki, M, 2021) |
| "A direct relationship between serum uric acid levels and hypertension, cardiovascular, renal and metabolic diseases has been reported in many basic and epidemiological studies." | 9.41 | Update in uric acid, hypertension, and cardiovascular diseases. ( Ae, R; Andres-Hernando, A; Borghi, C; Hisatome, I; Kanbay, M; Kodama, T; Kuwabara, M; Lanaspa, MA, 2023) |
| "Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) is well controlled." | 9.41 | Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia. ( Abe, Y; Fukumoto, Y; Hisatome, I; Hongou, M; Hoshide, S; Kario, K; Kasai, T; Kiuchi, M; Kiyosue, A; Kuga, H; Kuramochi, J; Miyazaki, S; Nishizawa, M; Ohtani, H; Tomita, F; Yasu, T, 2021) |
| "We conducted a post hoc analysis of results from a prospective trial in which the proteinuria-reducing effects of losartan and enalapril were compared." | 9.41 | Effects of losartan and enalapril on serum uric acid and GFR in children with proteinuria. ( Bryant, CE; Hogg, RJ; Rajai, A; Webb, NJA, 2021) |
| "To investigate the association of baseline serum uric acid (UA) with new-onset diabetes, and to explore the possible effect modifiers in Chinese adults with hypertension." | 9.34 | Positive association of serum uric acid with new-onset diabetes in Chinese women with hypertension in a retrospective analysis of the China Stroke Primary Prevention Trial. ( Hu, W; Liang, M; Liu, C; Liu, L; Liu, M; Nie, J; Qin, X; Song, Y; Wang, B; Wang, X; Xu, X; Zhang, Y; Zhang, Z; Zhou, C, 2020) |
| "To assess the efficacy and safety of febuxostat extended release (XR) and immediate release (IR) in patients with gout and normal or impaired renal function." | 9.30 | Efficacy and Safety of Febuxostat Extended and Immediate Release in Patients With Gout and Renal Impairment: A Phase III Placebo-Controlled Study. ( Becker, MA; Castillo, M; Gunawardhana, L; Hunt, B; Kisfalvi, K; Saag, KG; Whelton, A, 2019) |
| "The European Lacidipine Study on Atherosclerosis (ELSA) was a randomized, double-blind, multicenter trial comparing the effects of a 4-year treatment with either lacidipine or atenolol on progression of carotid atherosclerosis in patients with moderate hypertension." | 9.30 | Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis. ( Bombelli, M; Cuspidi, C; Facchetti, R; Grassi, G; Macchiarulo, M; Maggiolini, D; Mancia, G; Parati, G, 2019) |
| "Uric acid (UA) is a promising protective treatment in ischaemic stroke, but the precise molecular targets underlying its in vivo beneficial actions remain unclear." | 9.30 | Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension. ( Amaro, S; Chamorro, Á; D'Ocon, P; Dantas, AP; Jiménez-Altayó, F; Masip, N; Planas, AM; Puertas-Umbert, L; Solé, M; Unzeta, M; Vila, E, 2019) |
| "To examine whether partial replacement of a diet typical of the average American diet with Dietary Approaches to Stop Hypertension (DASH)-related foods in the home environment lowers the serum uric acid (UA) level in individuals with hypertension." | 9.27 | Effects of a Dietary Approach to Stop Hypertension (DASH) Diet Intervention on Serum Uric Acid in African Americans With Hypertension. ( Cooper, LA; Juraschek, SP; Miller, ER; Tang, O; White, K; Yeh, HC, 2018) |
| " This study aimed to explore the correlation between serum uric acid (SUA) concentration and hypertensive retinopathy in hypertensive adults." | 9.24 | Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults. ( Chen, X; Gu, X; Hou, F; Huo, Y; Li, J; Liao, R; Meng, Y; Peng, Y; Qin, X; Shang, K; She, H; Tang, G; Wang, B; Xu, X; Yang, L; Yang, W; Zhang, J; Zhang, Y; Zhao, L, 2017) |
| "There is little evidence guiding selection of nondiuretic, antihypertensive agents with a goal of lowering uric acid (SUA) and minimizing gout risk." | 9.24 | Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension. ( Appel, LJ; Juraschek, SP; Miller, ER, 2017) |
| "Hyperuricemia is associated with hypertension, with elevated serum uric acid levels postulated to have a causal role in the development of hypertension." | 9.24 | Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study. ( Feig, DI; Gunawardhana, L; Hunt, B; McLean, L; Palmer, RN; Punzi, HA; Whelton, A, 2017) |
| "Uric acid (UA) has been associated with hypertension, renal disease and cardiovascular disease." | 9.24 | Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia. ( Arima, H; Hayashi, S; Ishizuka, A; Iwashima, Y; Kawano, Y; Kishida, M; Nakamura, S; Ohta, Y; Yoshihara, F, 2017) |
| "Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension." | 9.22 | Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk. ( Agnoletti, D; Borghi, C; Cicero, AFG; Lurbe, E; Virdis, A, 2022) |
| "Studies examining the association between levels of serum uric acid (SUA) and risk of prehypertension still remained controversial conclusions." | 9.22 | Serum uric acid and risk of prehypertension: a dose-response meta-analysis of 17 observational studies of approximately 79 thousand participants. ( Han, M; Hong, F; Li, Q; Liu, L; Qie, R; Zhan, S; Zhang, C; Zhang, J; Zhang, L; Zhang, X, 2022) |
| "A relationship of blood uric acid (UA) with hypertension and cardiovascular risk is under debate thus salt intake is hypothesized to contribute to such associations." | 9.22 | Influence of Salt Intake on Association of Blood Uric Acid with Hypertension and Related Cardiovascular Risk. ( Asaiti, K; Han, W; Hou, L; Jiang, J; Liang, S; Pang, H; Qiu, C; Tang, Y; Wang, W; Wang, Y; Wang, Z; Xue, F; Zhang, B; Zhang, M, 2016) |
| "Forty-four adolescents, aged 12-19 years, newly diagnosed as essential hypertension (secondary hypertension was excluded) and previously untreated were randomized (open label trial) to receive either enalapril or enalapril plus allopurinol in combination." | 9.19 | Allopurinol enhances the blood pressure lowering effect of enalapril in children with hyperuricemic essential hypertension. ( Assadi, F, 2014) |
| " In this study, we assessed the additive effects of hydrochlorothiazide (HCTZ) on reducing proteinuria in CKD patients under treatment with losartan (LS)." | 9.19 | Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension. ( Fujisaki, K; Higashi, H; Hirakata, H; Kanai, H; Katafuchi, R; Kitazono, T; Nakano, T; Nakayama, M; Taniguchi, M; Tsuruya, K, 2014) |
| "Previous epidemiologic studies have demonstrated an association between uric acid and hypertension." | 9.17 | Does decreasing serum uric acid level prevent hypertension? - a nested RCT in cohort study: rationale, methods, and baseline characteristics of study cohort. ( Huang, G; Jiao, H; Lu, W; Song, K; Wang, G; Wang, Y; Zhang, Q, 2013) |
| "We examined blood pressure reduction and metabolic alterations after amlodipine/benazepril and valsartan/hydrochlorothiazide treatment in patients with type 2 diabetes mellitus and hypertension and microalbuminuria." | 9.16 | Comparison of the efficacy and safety profiles of two fixed-dose combinations of antihypertensive agents, amlodipine/benazepril versus valsartan/hydrochlorothiazide, in patients with type 2 diabetes mellitus and hypertension: a 16-week, multicenter, rando ( Chen, JF; Hung, YJ; Lee, IT; Lee, WJ; Sheu, WH; Wang, CY, 2012) |
| "The purpose of the study was to investigate the effect of interval and continuous training program on blood pressure and serum uric acid (SUA) levels in subjects with hypertension." | 9.15 | Comparative effect of interval and continuous training programs on serum uric acid in management of hypertension: a randomized controlled trial. ( Lamina, S, 2011) |
| "Excessive fructose intake causes metabolic syndrome in animals and can be partially prevented by lowering the uric acid level." | 9.14 | Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. ( Johnson, RJ; Lillo, JL; Nakagawa, T; Perez-Pozo, SE; Sánchez-Lozada, LG; Schold, J, 2010) |
| " Serum insulin, glucose, C-reactive protein (CRP), lipids, uric acid, YKL-40 and blood pressure were measured and insulin sensitivity was calculated (HOMA) at the beginning and end of each study phase." | 9.14 | Effect of moxonidine and amlodipine on serum YKL-40, plasma lipids and insulin sensitivity in insulin-resistant hypertensive patients-a randomized, crossover trial. ( Majer, J; Masajtis-Zagajewska, A; Nowicki, M, 2010) |
| "The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) > or = 8." | 9.14 | The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. ( Becker, MA; Espinoza, LR; Lademacher, C; Lloyd, E; MacDonald, P; Schumacher, HR; Wells, AF, 2010) |
| "It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH)." | 9.14 | Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study. ( Dahlöf, B; Devereux, RB; Høieggen, A; Ibsen, H; Kjeldsen, SE; Larstorp, AC; Lindholm, L; Okin, PM; Olsen, MH; Wachtell, K; Wiik, BP, 2010) |
| "To determine whether lowering uric acid lowers blood pressure (BP) in hyperuricemic adolescents with newly diagnosed hypertension." | 9.13 | Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. ( Feig, DI; Johnson, RJ; Soletsky, B, 2008) |
| "To survey the prevalence of hyperuricacidemia and serum uric acid (SUA) changes and electrolyte changes after 6 weeks antihypertensive treatment with thiazide diuretics, losartan or losartan+hydrochlorothiazide (Hyzaar) in patients with essential hypertension (EH)." | 9.13 | [Serum uric acid prevalence and changes post various antihypertensive agents in patients with essential hypertension]. ( Chen, H; Gui, W; Lu, LH; Wu, XY; Yang, LQ; Yu, L, 2008) |
| "This study used ambulatory blood pressure monitoring (ABPM) to compare the blood pressure (BP)-lowering effects of valsartan and enalapril over the 24 hours after missing 1 dose in previously untreated patients with mild to moderate essential hypertension." | 9.13 | Ambulatory blood pressure-lowering effects of valsartan and enalapril after a missed dose in previously untreated patients with hypertension: a prospective, randomized, open-label, blinded end-point trial. ( Ayala, DE; Calvo, C; Hermida, RC; Khder, Y, 2008) |
| "Our aim in this study was to investigate the changes of serum high-sensitive C-reactive protein (hs-CRP) and uric acid (UA), and evaluate the synergistic effect of amlodipine and atorvastatin on blood pressure and left ventricular remodeling in hypertensive patients with primary hypercholesterolemia." | 9.13 | Synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling, and C-reactive protein in hypertensive patients with primary hypercholesterolemia. ( Chen, YD; Ge, CJ; Hu, SJ; Ji, Y; Lu, SZ; Wu, XF, 2008) |
| " Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases." | 9.12 | Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis. ( Kimura, Y; Kono, H; Tsukui, D, 2021) |
| "Studies on the association of uric acid with mortality and cardiovascular outcomes in patients with hypertension have produced contradictory results." | 9.12 | Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis. ( Jin, Z; Yang, Y; Zhang, X; Zhao, Q, 2021) |
| "It is still undefined whether serum uric acid (SUA) is an independent risk factor for target organ damage (TOD) and cardiovascular events in human hypertension." | 9.12 | Lack of association between serum uric acid and organ damage in a never-treated essential hypertensive population at low prevalence of hyperuricemia. ( Cuspidi, C; Esposito, A; Mancia, G; Meani, S; Sala, C; Valerio, C; Zanchetti, A, 2007) |
| " This study was designed to compare the effects of losartan and eprosartan on uric acid metabolism in patients with mild to moderate essential hypertension." | 9.09 | Effect of eprosartan and losartan on uric acid metabolism in patients with essential hypertension. ( Buño, A; Dal-Ré, R; Mateos, F; Ortega, R; Puig, JG; Rodriguez, F, 1999) |
| "The purpose of this study was to assess the safety and antihypertensive dose-response effects of irbesartan and hydrochlorothiazide (HCTZ) in patients with mild-to-moderate hypertension." | 9.09 | Matrix study of irbesartan with hydrochlorothiazide in mild-to-moderate hypertension. ( Guthrie, R; Kassler-Taub, K; Kochar, M; Reeves, RA; Triscari, J, 1999) |
| "In this case-control study in uncomplicated subjects with essential hypertension, losartan and enalapril, alone or combined with a diuretic, effectively and equally lowered office and ambulatory blood pressure and induced a significant reduction in left ventricular mass during long-term treatment." | 9.09 | Long-term effects of losartan and enalapril, alone or with a diuretic, on ambulatory blood pressure and cardiac performance in hypertension: a case-control study. ( Benemio, G; Bruni, B; Porcellati, C; Reboldi, GP; Sacchi, N; Schillaci, G; Verdecchia, P, 2000) |
| "Serum uric acid independently predicts cardiovascular events in older persons with isolated systolic hypertension." | 9.09 | Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). ( Applegate, WB; Di Bari, M; Franse, LV; Pahor, M; Shorr, RI; Somes, GW; Wan, JY, 2000) |
| "These favourable effects of comicronised fenofibrate both on lipid and non lipid parameters, including insulin sensitivity, may confer to this product a particular interest in the treatment of patients with polymetabolic syndrome X." | 9.09 | Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X. ( Blane, G; Idzior-Walus, B; Kawalec, E; Rostworowski, W; Sieradzki, J; Wójcik, J; Zarnecki, A; Zdzienicka, A, 2000) |
| "We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged >/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure >/=160/<95 mm Hg)." | 9.09 | Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension. ( Birkenhäger, WH; Fagard, RH; Gong, L; Liu, L; Staessen, JA; Wang, JG, 2001) |
| "Patients > or = 21 years of age with mild to moderate hypertension, defined as a trough sitting diastolic blood pressure (SiDBP) between 95 and 115 mm Hg, were randomized to receive once-daily losartan (50 mg) or valsartan (80 mg) for 12 weeks." | 9.09 | Losartan versus valsartan in the treatment of patients with mild to moderate essential hypertension: data from a multicenter, randomized, double-blind, 12-week trial. ( Calhoun, DA; DeLucca, PT; Elliott, WJ; Gazdick, LP; Kerns, DE; Zeldin, RK, 2001) |
| "This study was conducted in 19 patients with mild or moderate essential hypertension randomised open trial to evaluate the influence of potassium losartan dosed 50 mg per day on blood pressure, metabolic processes and left ventricular heart function." | 9.09 | [Estimation of blood pressure, selected biochemical parameters and indices of left ventricular heart function in patients with mild or moderate essential hypertension treated with potassium losartan]. ( Badowski, R; Cieślik, P; Haczkiewicz, P; Hefczyc, J; Hrycek, A; Scieszka, J, 2001) |
| "The pharmacokinetic and pharmacodynamic alterations of multiple doses of losartan, an angiotensin II receptor antagonist, were examined in nine patients with essential hypertension." | 9.08 | Clinical pharmacology of multiple-dose losartan, an angiotensin II receptor antagonist, in patients with essential hypertension. ( Ebihara, A; Fujimura, A; Harada, K; Sasaki, M; Sunaga, K, 1996) |
| "We examined the renal hemodynamic modifications induced by a selective angiotensin II (AII) AT1 receptor antagonist, losartan, in 10 patients with essential hypertension." | 9.08 | Effects of losartan on renal function in patients with essential hypertension. ( Berra, N; Fauvel, JP; Laville, M; Madonna, O; Pozet, N; Velon, S; Zech, P, 1996) |
| "Antihypertensive therapy with low-dose chlorthalidone (supplemented if necessary) for isolated systolic hypertension lowers blood pressure and its cardiovascular disease complications and has relatively mild effects on other cardiovascular disease risk factor levels." | 9.08 | Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: The Systolic Hypertension in the Elderly Program. SHEP Cooperative Re ( Applegate, WB; Black, HR; Cohen, J; Curb, JD; Davis, BR; Frost, P; Gonzalez, N; Guthrie, GP; Oberman, A; Pressel, SL; Probstfield, JL; Rutan, G; Savage, PJ; Schron, EB; Smith, W; Stamler, J, 1998) |
| " Therefore, the effects of single and repeated doses of eprosartan on uric acid excretion were evaluated in 57 male patients with mild-to-moderate essential hypertension in a double-blind, randomized, placebo-controlled, repeated dose, dose-rising, two-period, period-balanced, crossover study conducted in two parts." | 9.08 | The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension. ( Boike, SC; Ilson, BE; Jorkasky, DK; Martin, DE, 1998) |
| "The antihypertensive efficacy of single-drug therapy with nifedipine (N), prazosin (P), or acebutolol (A) and the influence of these agents on coronary risk factors including hypoglycemia, hyperuricemia, and hyperlipidemia, were studied in adolescents with hypertension." | 9.07 | [Evaluation of the efficacy and tolerance of three antihypertensive agents used as single-drug therapy, nifedipine, prazosin and acebutolol in severe, idiopathic hypertension in adolescents]. ( Cichocka, E; Januszewicz, P; Wyszynska, T, 1993) |
| "Twenty-three patients with essential hypertension were treated consecutively with prazosin or dihydrochlorothiazide or the combination of the two, each treatment period lasting for three months." | 9.06 | Prazosin improves atherogenic index and inhibits the deleterious effect of dihydrochlorothiazide in patients with essential hypertension. ( Balás-Eltes, A; Farsang, C; Fehér, J; Péter, M, 1987) |
| "The blood pressure of patients with hypertension who were aged between 60 and 75 years responded equally well to treatment with metoprolol (100 mg a day) or hydrochlorothiazide (25 mg a day) in a double-blind study which employed random allocation to two parallel groups." | 9.06 | Metoprolol or hydrochlorothiazide in patients with hypertension aged 60-75 years. With special reference to assessment of compliance. Hunter Hypertension Research Group. ( , 1986) |
| "The short-term effects of manipulating dietary salt intake on plasma levels of cholesterol, lipoproteins and uric acid were studied in two groups of patient with essential hypertension." | 9.06 | Changes in plasma lipids and uric acid with sodium loading and sodium depletion in patients with essential hypertension. ( Hasegawa, T; Hashizume, K; Kumahara, Y; Masugi, F; Ogihara, T; Sakaguchi, K, 1988) |
| "5 mg indapamide was compared in patients with essential hypertension, known as responders to diuretic therapy." | 9.06 | Comparative study on the antihypertensive efficacy of torasemide and indapamide in patients with essential hypertension. ( Achhammer, I; Glocke, M; Metz, P; Spannbrucker, N, 1988) |
| "This randomised, double-blind, crossover study investigated the haemodynamic effects of a beta-blocker (atenolol 50mg) and a calcium antagonist (sustained release nifedipine 20mg) given either separately or in combination in 3 groups of patients with mild to moderate essential hypertension." | 9.06 | Efficacy and tolerability of atenolol, nifedipine and their combination in the management of hypertension. ( Heath, ID; Larkin, H; Stanley, NN; Thirkettle, JL; Varma, MP, 1988) |
| "Nifedipine has been used in hypertension, mainly as a third-line drug for rapid blood pressure reduction, for over 10 years." | 9.06 | Is nifedipine a suitable first-line treatment for essential hypertension in general practice? ( Adams-Strump, BJ; Gaw, N; Langan, JJ; Murray, TS; Sullivan, FM, 1987) |
| "One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12." | 9.06 | Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986) |
| "41 patients (35 males and 6 females) with moderate hypertension were treated with a combination of methyldopa/hydrochlorothiazide/amiloride (M/HCT/A)." | 9.05 | [A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension]. ( Bolzano, K; Krempler, F; Sandhofer, F, 1984) |
| "The results of an investigation to assess the clinical responses of patients with mild to moderate hypertension to a new combination formulation containing 75 mg triamterene and 50 mg hydrochlorothiazide are reported." | 9.05 | Clinical experience with a new combination formulation of triamterene and hydrochlorothiazide (Maxzide) in patients with mild to moderate hypertension. ( Blume, CD; Clark, T; Williams, RL, 1984) |
| "The efficacy and acceptability of a single half-tablet daily of a fixed combination of 400 mg acebutolol and 25 mg hydrochlorothiazide was assessed in a study of 35 patients suffering from mild to moderate essential hypertension." | 9.05 | The efficacy and acceptability of the combination of acebutolol and hydrochlorothiazide in the treatment of essential hypertension. ( Sugeng, I; Suryaatmaja, M; Sutandar, H; Utama, H, 1984) |
| "The effect of a single daily dose of timolol, hydrochlorothiazide and amiloride hydrochloride in fixed combination (Moducren; MDS) in patients with mild to moderate essential hypertension was tested during 1978 in an open study covering 10 weeks per patient." | 9.05 | Evaluation of a fixed combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A long-term multicentre trial. ( Pittaway, D, 1980) |
| "The antihypertensive effect of propranolol, in fixed combinations with two dosages of triamteren and hydrochlorothiazide (Dociteren), was evaluated in a double-blind test on 19 patients with uncomplicated essential hypertension." | 9.05 | [Propranolol, triamteren and hydrochlorothiazide in fixed combinations in the treatment of hypertension (author's transl)]. ( Herrmann, JM; Hiemstra, S; Hoenig, B, 1981) |
| "The dose response curve for 25, 50, 75 and 100 mg doses of chlorthalidone was studied in double blind fashion over an 8 week period in patients who presented with untreated mild hypertension." | 9.05 | Chlorthalidone in mild hypertension - dose response relationship. ( Humphries, IS; Mayhew, SR; Russell, JG, 1981) |
| "Twentysix women with pregnancy-induced hypertension have been randomly treated with either labetalol or Aldomet." | 9.05 | Comparison of the alpha and beta blocking drug, labetalol, and methyl dopa in the treatment of moderate and severe pregnancy-induced hypertension. ( Broughton Pipkin, F; Lamming, GD; Symonds, EM, 1980) |
| "Plasma urea and urate concentrations were determined daily for up to seven days in 40 pregnant women who had been admitted to hospital because of proteinuric hypertension and who were then allocated at random to either complete rest in bed or to being allowed to move freely in the ward." | 9.05 | The effect of rest and ambulation on plasma urea and urate levels in pregnant women with proteinuric hypertension. ( Agarwal, V; Mathews, DD; Shuttleworth, TP, 1980) |
| "Captopril (Capoten; Squibb) 100 mg was given as once-daily monotherapy in 20 patients with hypertension and hyperuricaemia." | 9.05 | Captopril once daily in patients with essential hypertension and hyperuricaemia. ( Acosta-Barrios, T; Leary, WP; Maharaj, B; Reyes, AJ, 1985) |
| "In a double-blind study, 28 patients having mild to moderate essential hypertension were randomly assigned to a 6-week regimen of ticrynafen, hydrochlorothiazide, or placebo." | 9.04 | Ticrynafen and hydrochlorothiazide in hypertension. ( Beg, M; Okun, R, 1978) |
| " A double-blind comparison of the effect of tienylic acid and hydrochlorothiazide on blood pressure was made in patients with moderate hypertension." | 9.04 | A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension. ( Gillies, AH; Morgan, TO, 1978) |
| "A double-blind study of hydrochlorothiazide and spironolactone, alone and in combination, was conducted in 49 patients with mild-to-moderate essential hypertension after a 4-wk placebo washout period." | 9.04 | Hydrochlorothiazide and spironolactone in hypertension. ( Schrijver, G; Weinberger, MH, 1979) |
| "Fifty-three pregnant women with moderately severe hypertension were randomly allocated to treatment with methyldopa or oxprenolol." | 9.04 | Randomised comparison of methyldopa and oxprenolol for treatment of hypertension in pregnancy. ( Gallery, ED; Györy, AZ; Hunyor, SN; Saunders, DM, 1979) |
| "The effect on BP of 100 and 200 mg spironolactone/day has been compared with that of methyl-dopa, 750 mg/day, and with combined treatment with both drugs in 32 patients with essential hypertension." | 9.04 | The effect of spironolactone (Aldactone) and methyldopa in low and normal renin hypertension. ( Giezendanner, L; Solheim, SB; Sundsfjord, JA, 1975) |
| " For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome." | 8.98 | Uric Acid as a Cause of the Metabolic Syndrome. ( Jensen, T; Johnson, RJ; King, C; Lanaspa, MA; Sánchez-Lozada, LG; Tolan, DR, 2018) |
| "Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome through the oxidative stress and the inflammatory response induced by XOR-derived reactive oxygen species and uric acid." | 8.98 | The role of xanthine oxidoreductase and uric acid in metabolic syndrome. ( Battelli, MG; Bolognesi, A; Bortolotti, M; Polito, L, 2018) |
| "Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases." | 8.95 | Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review. ( Astell-Burt, T; Chen, S; Duan, D; Duan, S; Feng, X; Gu, K; Han, L; Liu, Y; Lu, N; Ma, J; Tang, L; Wang, C; Wang, K; Wen, Q; Xu, G; You, D; Zhang, L; Zhang, T, 2017) |
| "Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease." | 8.93 | Uric acid in metabolic syndrome: From an innocent bystander to a central player. ( Jensen, T; Johnson, RJ; Kanbay, M; Lanaspa, MA; Le, M; Nakagawa, T; Rivard, C; Roncal-Jimenez, C; Solak, Y, 2016) |
| "To discuss the evolving data regarding uric acid as a potential cause of hypertension and progressive renal dysfunction and its clinical and research implications." | 8.90 | Serum uric acid and the risk of hypertension and chronic kidney disease. ( Feig, DI, 2014) |
| "Elevated serum uric acid concentration is a common laboratory finding in subjects with metabolic syndrome/obesity, hypertension, kidney disease and cardiovascular events." | 8.89 | Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? ( Kapusta, DR; Rasheed, K; Reisin, E; Soltani, Z, 2013) |
| "Over the last decade, the biologic interference of uric acid with the cardiovascular (CV) system and the kidney has been intensively investigated, and several experimental studies in animal models and in vitro documented that hyperuricemia may trigger hypertension and incite endothelial dysfunction, vascular damage and renal disease." | 8.89 | Uric acid, hypertension, and cardiovascular and renal complications. ( Mallamaci, F; Zoccali, C, 2013) |
| " Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD." | 8.89 | Serum uric acid and chronic kidney disease: the role of hypertension. ( Dehghan, A; Franco, OH; Hofman, A; Hoorn, EJ; Sedaghat, S; van Rooij, FJ; Witteman, JC, 2013) |
| "Uric acid has been suspected to be a risk factor for hypertension since the 1870s." | 8.88 | The role of uric acid in the pathogenesis of hypertension in the young. ( Feig, DI, 2012) |
| "Uric acid (UA) increase is considered an important risk factor for the development of cardiovascular disease (CVD) favoring oxidative stress and endothelial dysfunction and is also involved in metabolic syndrome (MS) pathophysiology." | 8.88 | The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome. ( Dichi, I; Lozovoy, MA; Simão, AN, 2012) |
| "Uric acid is a terminal metabolite of the degradation of nucleotides, which increases their blood levels in patients with preeclampsia-eclampsia, increasing its synthesis by damage and death of trophoblastic cells in proliferation and decreased urinary excretion due a lower glomerular filtration rate and increased absorption in the proximal tubule." | 8.87 | [Role of uric acid in preeclampsia-eclampsia]. ( Rico-Trejo, EI; Vázquez-Rodríguez, JG, 2011) |
| "A link between serum uric acid and the development of hypertension was first hypothesized in the 1870s." | 8.87 | Uric acid and hypertension. ( Feig, DI, 2011) |
| "Uric acid was first associated with primary hypertension in 1874, yet its role in this condition remains unclear." | 8.86 | Uric acid and hypertension: cause or effect? ( Feig, DI; Jalal, D; Johnson, RJ; Kanbay, M; Mazzali, M; Segal, MS; Shafiu, M, 2010) |
| "After uric acid was recognized as the causative factor in gout, increased prevalence of renal disease and hypertension in this patient population caught the attention of the medical community." | 8.86 | Uric acid in hypertension and renal disease: the chicken or the egg? ( Covic, A; Dogan, E; Kanbay, M; Lanaspa, MA; Solak, Y, 2010) |
| "After adjustment for age, body mass index, and other covariates, the relative risks (RRs) of developing hypertension comparing the highest and lowest uric acid quartiles were 1." | 8.85 | Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis. ( Hu, FB; Hui, R; Sun, K; Yang, Y; Zhang, H; Zhang, W, 2009) |
| " Recently it has been identified that hypertension are frequently associated with myogenic hyperuricemia converted from overproduced hypoxanthine in the skeletal muscles." | 8.84 | [Idiopathic hyperuricemia with overproduction of uric acid]. ( Hisatome, I; Igawa, O; Mizuta, E, 2008) |
| "Epidemiologic studies published during the past 3 years support the possible role of uric acid in the onset of essential hypertension." | 8.83 | Uric acid and hypertension. ( Feig, DI; Johnson, RJ; Kang, DH; Mazzali, M; Nakagawa, T, 2006) |
| "In a retrospective chart review, we identified 95 children with confirmed, new onset hypertension, and evaluated the cause of hypertension and parental history of hypertension, birth weight, and serum uric acid." | 8.82 | Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. ( Feig, DI; Finch, J; Johnson, RJ; Kang, DH; Karumanchi, SA; Nakagawa, T; Oliver, WJ, 2004) |
| "This article critically evaluates the clinical evidence regarding the influence of uric acid on hypertension, cardiovascular disease, and kidney disease." | 8.82 | Clinical evidence for the influence of uric acid on hypertension, cardiovascular disease, and kidney disease: a statistical modeling perspective. ( Short, RA; Tuttle, KR, 2005) |
| "Many large epidemiological studies confirmed a positive association between raised serum uric acid (SUA) levels and risk of coronary heart disease (CHD) or cardiovascular disease (CVD) in the general population, among hypertensive patients and those with established CHD, stroke, diabetes and heart failure." | 8.82 | Serum uric acid and risk of coronary heart disease. ( Wannamethee, SG, 2005) |
| "Many large epidemiologic studies have confirmed a positive association between raised serum uric acid and risk of coronary heart disease or cardiovascular disease, both in the general population and among hypertensive patients." | 8.81 | Serum uric acid is not an independent risk factor for coronary heart disease. ( Wannamethee, SG, 2001) |
| "The role of uric acid as an independent risk factor in the development of coronary heart disease (CHD) has been questioned as serum urate is related to many of the established etiological risk factors for cardiovascular disease which could confound the observed association." | 8.80 | Is serum uric acid a risk factor for coronary heart disease? ( Wannamethee, SG, 1999) |
| "Elevated serum uric acid (SUA) is associated with the incidence of hypertension, but whether relevant metabolic factors have mediating effects is not certain." | 8.31 | Association of serum uric acid with the risk of developing hypertension: A prospective cohort study with mediation analysis. ( Chu, X; Dong, J; Hu, LK; Liu, YH; Lu, YK; Yan, YX, 2023) |
| "The authors examined the sex-specific association between serum uric acid (SUA) levels and achievement of target blood pressure among Japanese patients with hypertension." | 8.31 | Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension. ( Aoki, N; Fukuda, H; Hisaoka, T; Naito, T; Sato, Y; Suzuki, M; Yokokawa, H, 2023) |
| "Since both serum uric acid (SUA) and renal artery stenosis (RAS) are associated with atherosclerotic events and renal events, it is interesting to investigate whether SUA could predict long-term outcome in patients with RAS." | 8.31 | Concentration of serum uric acid in patients with Renal Artery Stenosis and Hypertension prEdict Future nephropathy and death: C-RASHEF study. ( Zheng, B, 2023) |
| "To explore the relationship between Dietary Approaches to Stop Hypertension (DASH) diet and serum uric acid (SUA) levels among the Chinese adult population, and verify the mediating effect of BMI between DASH diet and SUA levels." | 8.31 | Association between adherence to the Dietary Approaches to Stop Hypertension diet and serum uric acid. ( Cao, S; Feng, J; He, Y; Huang, Y; Ke, P; Lu, Z; Tian, Q; Wang, C; Wang, H; Xu, H, 2023) |
| "Higher serum uric acid (SUA) can cause gout, which is principally characterized by arthritis due to monosodium urate crystal deposition in the lower extremities." | 8.31 | Association between serum uric acid levels and peripheral artery disease in Chinese adults with hypertension. ( Bao, H; Cheng, X; Han, F; Hu, F; Huang, X; Wang, T; Yu, C; Zhou, W; Zhu, L, 2023) |
| "The aim of this study was to investigate the association between serum uric acid (UA) levels and hypertension in American individuals 20 years of age and older." | 8.31 | Relationship between serum uric acid and hypertension in the general US population aged 20 years and older: A cross-sectional study based on NHANES 2007 to 2016. ( Ouyang, Y; Wang, Y; Zhang, Y, 2023) |
| "Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population." | 8.31 | Serum uric acid is independently associated with hypertension in patients with polymyositis and dermatomyositis. ( Liu, M; Lu, K; Luo, Q; Wang, H; Zhao, T; Zhao, Z, 2023) |
| "To study the development of microalbuminuria (MAU) in essential hypertension (EHT), we investigated the association of MAU with central blood pressure (CBP), direct renin concentration (DRC), plasma aldosterone (PA), and uric acid (UA)." | 8.31 | Central diastolic blood pressure, plasma aldosterone and uric acid are associated with microalbuminuria in essential hypertension: a case-control study. ( Chou, H; Li, J; Li, Y; Shi, L; Wei, M; Yang, N, 2023) |
| "The relationship between uric acid (UA) and benign prostatic hyperplasia (BPH) is controversial and has rarely been studied in American populations." | 8.31 | Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008. ( Hao, X; Liu, X; Pan, Y; Xu, M; Xu, Z; Zhou, H, 2023) |
| "The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting combined (fatal and non-fatal) cerebrovascular (CBV) events in the whole database." | 8.12 | Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'elia, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Salvetti, M; Spinella, P; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2022) |
| "The impact of serum uric acid (sUA) levels on the clinical prognosis and severity of coronary artery disease in patients with acute coronary syndrome (ACS) and hypertension after percutaneous coronary intervention (PCI) is not fully clear." | 8.12 | Impact of serum uric acid levels on the clinical prognosis and severity of coronary artery disease in patients with acute coronary syndrome and hypertension after percutaneous coronary intervention: a prospective cohort study. ( Liu, X; Shao, Y; Song, B; Yu, H; Zhang, S; Zhang, X, 2022) |
| "This study is to investigate the correlation between serum uric acid levels and hyperhomocysteinemia Chinese adult patients with hypertension." | 8.12 | Serum uric acid concentration is associated with hyperhomocysteinemia in hypertensive Chinese adults. ( Wang, Q; Wang, W; Yang, N, 2022) |
| "Asymptomatic hyperuricemia (AHU) is elevated serum uric acid (UA) without symptoms." | 8.12 | Effects of uric acid-lowering therapy in patients with essential arterial hypertension. ( Bijak, M; Bilo, G; Drożdż, D; Drożdż, T; Gruszka, K; Hering, D; Jankowski, P; Rajzer, M; Terlecki, M; Wojciechowska, W, 2022) |
| " Whereas Serum Uric acid acts as a marker of tissue infarction; indicating poor prognosis of ischemic stroke." | 8.12 | A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke. ( Bc, PK; Somannavar, VG, 2022) |
| "The association of the metabolic syndrome with lithogenesis has been described, especially in uric acid stones." | 8.12 | Metabolic syndrome in calcium oxalate stones: Is it so important in this type of lithiasis? ( Arias Fúnez, F; Burgos Revilla, FJ; Duque Ruiz, G; Gomez Dos Santos, V; Hevia Palacios, M; Laso García, I; Sánchez Herranz, A, 2022) |
| "The role of uric acid as a risk factor for cerebrovascular disease, particularly acute ischemic stroke, is controversial and there is little information about this in our setting." | 8.12 | Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh. ( Hossain, MS; Jasmine, T; Kamrul-Hasan, AB; Rahman, MM; Saha, PK; Sarker, MA, 2022) |
| "This study aimed to investigate the adverse effects of serum uric acid concentration on the severity of chronic congestive heart failure." | 8.12 | The effect of serum uric acid concentration on the severity of chronic congestive heart failure. ( Al-Mohana, SJA; Alshamari, AHI; Kadhim, RK, 2022) |
| "Evidence is lacking about the role of serum uric acid (SUA) in the progression from prehypertension to hypertension." | 8.12 | Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study. ( Chen, S; Luo, Y; Mo, D; Tian, X; Wang, A; Wu, S; Zhang, L; Zuo, Y, 2022) |
| "Many studies have demonstrated that elevated serum uric acid independently increases the risk of developing hypertension." | 8.12 | Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study. ( Bai, Y; Bai, Z; Cheng, Z; Ding, J; Huang, P; Huang, W; Li, N; Liu, N; Wang, M; Wang, R; Wang, Y; Yang, J; Yin, C; Zhang, D; Zhang, R; Zheng, S, 2022) |
| "In the context of an aging population, this study aims to evaluate serum uric acid levels and arterial hypertension prevalence and control in a subgroup of Romanian adults (>65 years), concerning the influence of age on these parameters." | 8.02 | Arterial Hypertension and Serum Uric Acid in Elderly- SEPHAR III Study. ( Albulescu, N; Ardelean, M; Buzas, R; Dorobantu, M; Gheorghe-Fronea, OF; Ivan, VS; Lighezan, DF; Morgovan, AF, 2021) |
| "Serum uric acid (SUA) has been found correlated with an increased risk of hypertension, but evidence is sparse regarding the association in Gansu Province, especially in Yugur people." | 8.02 | Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey. ( Chang, L; He, H; Pan, L; Ren, X; Shan, G; Wang, Y; Xi, J; Yu, C; Zhao, H, 2021) |
| "The elevated serum uric acid (SUA) is associated with an increased risk of hypertension and nutritional status." | 8.02 | The geriatric nutritional risk index mediated the relationship between serum uric acid and hypertension: a mediation analysis. ( Cao, Z; Dai, S; Liu, X, 2021) |
| " Nevertheless, the association between uric acid levels and the development of albuminuria has been under-investigated in patients with type 2 diabetes mellitus." | 8.02 | Association between uric acid level and incidence of albuminuria in patients with type 2 diabetes mellitus: A 4.5-year cohort study. ( Chen, LJ; Chen, YY; Ku, PW; Lai, YJ; Yen, YF, 2021) |
| "Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial." | 8.02 | The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults. ( Guo, X; Huang, J; Huang, Y; Ji, Q; Wu, S; Xu, X, 2021) |
| "To assess the prognostic cut-off values of serum uric acid (SUA) in predicting fatal and morbid heart failure in a large Italian cohort in the frame of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension." | 8.02 | Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'Eliak, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Rattazzi, M; Rivasi, G; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2021) |
| "The URic acid Right for heArt Health (URRAH) study is a nationwide, multicentre, observational cohort study involving data on individuals recruited from all the Italy territory under the patronage of the Italian Society of Hypertension with an average follow-up period of 122." | 8.02 | Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study. ( Barbagallo, CM; Bernardino, B; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'elia, L; Dell'Oro, R; Desideri, G; Facchetti, R; Ferri, C; Galletti, F; Giannattasio, C; Grassi, G; Iaccarino, G; Lippa, L; Loreto, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pauletto, P; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Rosei, EA; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2021) |
| "BACKGROUND Serum uric acid (UA) is involved in the development of hypertension." | 8.02 | U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study. ( Chen, K; Han, P; You, H; Yue, C; Zhao, X, 2021) |
| "Elevated serum uric acid (SUA) is associated with hypertension according to its traditional definition." | 8.02 | Elevated serum uric acid is associated with incident hypertension in the health according to various contemporary blood pressure guidelines. ( Hwang, JJ; Ke, SR; Liu, CW; Tseng, GS; Wu, YW, 2021) |
| "The relationship between uric acid and incident hypertension tended to be dependent on age and sex." | 8.02 | Age and sex dependent association of uric acid and incident hypertension. ( Choi, CU; Choi, JY; Go, TH; Kang, DO; Kang, DR; Kim, EJ; Kim, JY; Kim, W; Lee, J; Na, JO; Park, CG; Rha, SW; Roh, SY; Seo, HS, 2021) |
| "To evaluate the condition of subclinical cardiac damage in children with primary hypertension and the association between serum uric acid and subclinical cardiac damage." | 8.02 | [Association between serum uric acid and subclinical cardiac damage in children with primary hypertension]. ( Cao, L; Ding, YY; Hou, M; Lyu, HT; Shen, J; Sun, L; Xu, QQ; Yang, DP; Zhou, WP, 2021) |
| "Patients with primary hypertension and without any uric acid (UA)-lowering treatment were enrolled." | 8.02 | Association of hyperuricemia and hypertension phenotypes in hypertensive patients without uric acid lowering treatment. ( Hou, J; Liao, H; Lin, J; Liu, C; Qiu, D; Zhang, M, 2021) |
| "Increased concentration of uric acid may play a role in the pathogenesis of primary hypertension (PH)." | 8.02 | [Uric acid in children and adolescents with primary hypertension]. ( Pańczyk-Tomaszewska, M; Skrzypczyk, P; Szyszka, M, 2021) |
| "We investigated serum uric acid changes and incident hyperuricemia in relation to the achieved blood pressure (BP) after 12 weeks of antihypertensive therapy with the irbesartan/hydrochlorothiazide combination." | 8.02 | Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination. ( Huang, QF; Li, Y; Wang, JG; Zhang, D, 2021) |
| " In this study, the differences between gout with cerebral infarction (gout+CI) and gout with coronary heart disease (gout+CHD) and related factors that affect serum uric acid (sUA) levels in gout+CI were investigated by a cross-sectional study." | 8.02 | Factors Influencing the Serum Uric Acid in Gout with Cerebral Infarction. ( Duan, L; Li, Y; Tian, Y; Yang, H, 2021) |
| "The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men." | 7.96 | Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Bruno, B; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'Elia, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Lippa, L; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2020) |
| "d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver." | 7.96 | The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. ( Amézqueta, S; Atienza, L; Casas, J; Hereu, M; Medina, I; Miralles-Pérez, B; Muñoz, S; Ramos-Romero, S; Romeu, M; Torres, JL, 2020) |
| "Leveraging a longitudinal cohort including 1981 Chinese adults who had blood pressures, urinary albumin to creatinine ratio (UACR), and uric acid measured twice 4 years apart, we examined the temporal relationships among hyperuricemia, microalbuminuria, and hypertension by cross-lagged panel analysis followed by a causal mediation analysis to confirm the temporal consequence." | 7.96 | Microalbuminuria mediates the association between serum uric acid and elevation of blood pressure: a longitudinal analysis in the Gusu cohort. ( He, Y; Jiang, Y; Li, J; Ma, S; Peng, H; Ren, L; Yu, J; Zhang, M; Zhang, Q, 2020) |
| " Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia and the predictors of sUA (serum uric acid) levels." | 7.96 | The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study. ( Gu, J; Huang, Y; Jiang, Y; Li, X; Liang, J; Ou, J; Song, W; Wei, Q, 2020) |
| "We investigate the association of uric acid with hypertension among Han, Uygur, and Kazakh populations in the Xinjiang Province of Western China." | 7.96 | Uric acid and its correlation with hypertension in postmenopausal women: A multi-ethnic study (Observational study). ( Chen, BD; Karmacharya, U; Liu, F; Ma, X; Ma, YT; Yuan, Q, 2020) |
| " Previous studies have shown that high serum uric acid (SUA) levels are an independent risk factor for hypertension, cardiovascular disease (CVD), and ischemic stroke." | 7.96 | Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis. ( Bai, CX; Chen, JZ; Ge, J; Hui, RT; Li, H; Liu, TL; Song, L; Song, WH; Sun, YY; Wen, HY; Xiao, N; Xu, HC; Zhang, YH, 2020) |
| "The role of serum uric acid (SUA) in development of myocardial infarction (MI) is controversial." | 7.96 | Associations between changes in serum uric acid and the risk of myocardial infarction. ( An, J; Chen, S; He, Y; Li, H; Luo, Y; Tian, X; Wang, A; Wu, S; Zhang, L; Zuo, Y, 2020) |
| "Elevated serum uric acid increases the risk of hypertension, and individuals born preterm have higher blood pressure (BP) and uric acid, but the mechanisms remain unclear." | 7.96 | Association of circulating uric acid and angiotensin-(1-7) in relation to higher blood pressure in adolescents and the influence of preterm birth. ( Chappell, MC; Diz, DI; Jensen, ET; Nixon, PA; O'Shea, TM; Shaltout, HA; South, AM; Washburn, LK, 2020) |
| " This study was designed to evaluate the influences of long-term xanthine oxidase inhibitor (febuxostat) prescription on left ventricular hypertrophy (LVH), left ventricular (LV) diastolic function, and new-onset heart failure with preserved ejection fraction (HFpEF) in these patients." | 7.96 | Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia. ( Gu, J; Lin, H; Pan, JA; Wang, CQ; Zhang, JF, 2020) |
| "For 40 years many studies have been conducted to verify the connection between serum uric acid concentration and cardiovascular diseases, such as myocardial infarction." | 7.96 | The differential role of uric acid - The purpose or cause of cardiovascular diseases? ( Siemińska, E; Sikora, J; Skibińska, N; Sobczak, P, 2020) |
| "To observe the changes in blood pressure (BP) over 10 years and to investigate current BP association to serum uric acid (SUA) levels and cardiovascular risk factors in the epidemiological data of a target group of patients with prehypertension in 2007." | 7.96 | Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study. ( Bawazier, LA; Irijanto, F; Kholiq, A; Sja'bani, M; Tomino, Y; Widiatmoko, A; Zulaela, Z, 2020) |
| "results indicate serum uric acid is positively correlated with hypertension and a reliable indicator of LVH in study population." | 7.96 | Serum uric acid and left ventricular hypertrophy in hypertensive patients in Ado-Ekiti. ( Adebayo, RA; Adewuya, OA; Ajayi, EA; Ojo, OE; Olaoye, OB, 2020) |
| "To analyze the efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia." | 7.91 | Clinical efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia. ( Gao, H, 2019) |
| "This study shows, for the first time, that 1) an unexpectedly high percentage (69%) of overweight/obese subjects is affected by hypertension; 2) early hypertensive subjects have an increased eGFR and higher FT4 serum levels; 3) lower potassium and uric acid levels are independent predictors of pathological nocturnal non-dipping." | 7.91 | Uric Acid and Potassium Serum Levels Are Independent Predictors of Blood Pressure Non-Dipping in Overweight or Obese Subjects. ( Boninfante, B; Castellana, F; De Pergola, G; Giannelli, G; Lampignano, L; Lattanzio, A; Sardone, R; Zupo, R, 2019) |
| "Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension." | 7.91 | Age-differential association between serum uric acid and incident hypertension. ( Ahn, SV; Kim, HC; Lee, HY; Lee, SW; Nam, C; Oh, YA; Suh, I, 2019) |
| "To identify common uric acid (UA) trajectories in middle-aged adults and to examine their association with the risk of hypertension." | 7.91 | Distinct Uric Acid Trajectories Are Associated With Different Risks of Incident Hypertension in Middle-Aged Adults. ( Guo, X; Li, X; Li, Y; Ma, H; Qi, L; Wang, X, 2019) |
| "Serum uric acid (SUA) had been associated with incident hypertension, but it is uncertain whether and to what extent the effect of SUA is mediated by other metabolic factors." | 7.91 | Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study. ( Cao, Z; Cheng, Y; Gao, Y; Li, S; Li, W; Sun, L; Wang, Y; Yang, H; Yu, P, 2019) |
| "Experimental evidence suggests a causal role of serum uric acid (SUA) in hypertension development." | 7.91 | Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults. ( Ali, N; Haque, N; Haque, T; Islam, F; Islam, S; Khanum, FA; Mahmood, S; Mosaib, G; Perveen, R; Rahman, S, 2019) |
| "Heterogeneous results have been obtained in the relationship between serum uric acid (SUA) and target organ damage (TOD) in patients with hypertension." | 7.88 | Sex-related relationships between uric acid and target organ damage in hypertension. ( Casati, M; Falbo, R; Giannattasio, C; Grassi, G; Maggioni, S; Maloberti, A; Nava, S; Occhi, L; Panzeri, F; Signorini, S; Triglione, N, 2018) |
| "The present study explored the gender interaction on the risk of uric acid in the new development of hypertension." | 7.88 | Gender interaction of uric acid in the development of hypertension. ( Hosoya, T; Kuriyama, S; Maruyama, Y; Nishio, S; Sugano, N; Yokoo, T, 2018) |
| "The role of serum uric acid (SUA) as a prognostic marker for incident heart failure (HF) in hypertensive subjects is uncertain." | 7.88 | Serum uric acid as a potential marker for heart failure risk in men on antihypertensive treatment: The British Regional Heart Study. ( Lennon, L; Papacosta, O; Wannamethee, SG; Whincup, PH, 2018) |
| "The purpose of this study was to examine the association between serum uric acid (sUA) and the incidence of hypertension in nonmetabolic syndrome (non-MetS) subjects." | 7.88 | Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study. ( Chen, Q; Chen, WY; Huang, X; Wu, JN; Yin, YJ, 2018) |
| "The objective of the present study was to evaluate clinical implications of serum uric acid (UA) on the progression of heart failure with preserved ejection fraction (HFpEF) in hypertensive patients." | 7.88 | Serum uric acid is associated with incidence of heart failure with preserved ejection fraction and cardiovascular events in patients with arterial hypertension. ( Fan, YQ; Gu, J; Wang, CQ; Zhang, HL; Zhang, JF, 2018) |
| "Little is known about the relationship between high baseline serum uric acid (SUA) and incident hypertension in patients with type 2 diabetes (T2D)." | 7.88 | Relationship Between Serum Uric Acid and Incident Hypertension in Patients with Type 2 Diabetes. ( Amini, M; Aminorroaya, A; Ghanbari, H; Janghorbani, M, 2018) |
| "Increasing evidence has shown that albuminuria is related to serum uric acid." | 7.88 | Urinary excretion of uric acid is negatively associated with albuminuria in patients with chronic kidney disease: a cross-sectional study. ( Chen, W; Fu, C; Guo, H; Li, F; Lu, Y; Xiao, J; Ye, Z; Zhang, X; Zou, J, 2018) |
| "Serum uric acid levels were associated with the future incidence of hypertension, and the association was observed in the younger individuals, those without diabetes, and those with preserved high-density lipoprotein cholesterol levels in a worksite population of Japanese men." | 7.88 | Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. ( Goto, K; Inoue, M; Kansui, Y; Kitazono, T; Kiyohara, K; Matsumura, K; Morinaga, Y; Ohta, Y; Ohtsubo, T; Ooboshi, H, 2018) |
| "This paper aims to evaluate the association between serum uric acid (SUA) levels, arterial hypertension (HT) prevalence, blood pressure values control, kidney function and intima media thickness (IMT), as a surrogate marker of early atherosclerosis, in a representative group of Romanian adult population." | 7.88 | Serum uric acid and arterial hypertension-Data from Sephar III survey. ( Buzas, R; Dorobantu, M; Ivan, V; Lighezan, D; Tautu, OF, 2018) |
| "This study aimed to examine gender differences in the association between serum uric acid (SUA) and the risk of prediabetes in a longitudinal cohort." | 7.88 | Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study. ( Chen, S; Guo, X; Liu, J; Mu, Y; Tao, L; Zhang, J; Zhao, Z; Zou, D; Zou, X, 2018) |
| "Little is known about the relationship serum uric acid (SUA) and hypertension in Chinese population." | 7.85 | An observational study on the relationship between serum uric acid and hypertension in a Northern Chinese population aged 45 to 59 years. ( Cheng, HY; Huang, XL; Liu, SS; Shi, YX; Yu, FN, 2017) |
| "Our aim was to investigate the association between serum uric acid (SUA) levels and the risk of first stroke in a Chinese population of hypertensive patients." | 7.85 | Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort. ( Cai, Y; Dong, Q; Fu, J; He, M; Huo, Y; Li, J; Qin, X; Shi, X; Tang, G; Wang, B; Wang, K; Wang, L; Xu, X; Yang, J; Zhang, C; Zhang, Y; Zhao, G; Zhao, M, 2017) |
| "Previous studies have examined the association between elevated serum uric acid (SUA) level and hypertension; however, the association in the Chinese elderly is still uncertain." | 7.85 | Association between serum uric acid level and hypertension in a Chinese elderly rural population. ( He, Y; Jiang, B; Liu, M; Wang, J; Wang, Y; Wu, L; Zeng, J; Zhang, D, 2017) |
| "To disclose the link between the composition of urolithiasis, especially that of uric acid calculi, and obesity, prediabetes, type 2 diabetes mellitus, and hypertension." | 7.85 | The Association of Uric Acid Calculi with Obesity, Prediabetes, Type 2 Diabetes Mellitus, and Hypertension. ( Chang, CC; Chu, FY; Ho, JL; Huang, PH; Ku, PW; Lin, YN; Su, MJ; Sun, JT; Yen, TH, 2017) |
| "An elevated serum uric acid concentration may be associated with hypertension, which is the leading cause of death worldwide." | 7.85 | Serum Uric Acid Concentrations Can Predict Hypertension: A Longitudinal Population-Based Epidemiological Study. ( Chen, C; Chen, Q; Mao, Y; Yang, T; Zheng, R, 2017) |
| "Patients with both hypertension and hyperhomocysteinemia, termed H-type hypertension, have a high risk for cardiocerebrovascular diseases." | 7.85 | Prevalence of Homocysteine-Related Hypertension in Patients With Chronic Kidney Disease. ( Li, Y; Lou, T; Ma, X; Peng, H; Wang, C; Ye, Z; Zhang, J; Zhang, Q, 2017) |
| "It is uncertain whether high-baseline uric acid (UA) or change in UA concentration over time is related to development of incident hypertension." | 7.85 | Baseline and Change in Uric Acid Concentration Over Time Are Associated With Incident Hypertension in Large Korean Cohort. ( Byrne, CD; Guallar, E; Kim, JY; Kim, SH; Lee, JY; Lee, SH; Ryu, S; Sung, KC; Wild, SH, 2017) |
| "Objective To explore the possible correlation between uric acid levels and leukoaraiosis (LA)." | 7.85 | The association of uric acid with leukoaraiosis. ( Cai, RW; Chen, YF; Huang, YH; Li, JJ; Li, MM; Lin, YY, 2017) |
| "The association between serum uric acid (SUA) and left ventricular hypertrophy (LVH) is controversial and the ability of SUA in predicting incident LVH remains unsettled." | 7.85 | Uric Acid and New Onset Left Ventricular Hypertrophy: Findings From the PAMELA Population. ( Bombelli, M; Cuspidi, C; Facchetti, R; Grassi, G; Mancia, G; Sala, C; Tadic, M, 2017) |
| "The objective was to determine whether serum uric acid concentrations were associated with metabolic syndrome in a population from Wuhan." | 7.85 | Positive association between metabolic syndrome and serum uric acid in Wuhan. ( Chen, M; Fan, ZF; Fu, YQ; Li, D; Wang, L; Yang, H; Zeng, W; Zeng, XY; Zheng, JS, 2017) |
| "Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already been reported." | 7.83 | Uric acid blood levels and relationship with the components of metabolic syndrome in hypertensive patients. ( Kalogeropoulos, P; Karamanou, AG; Moustakas, G; Papavasileiou, MV; Patsianis, S; Pittaras, A, 2016) |
| "This cross-sectional study from January 2012 to December 2012 aimed to examine the sex-specific association between serum uric acid (SUA) levels/hyperuricemia and hypertension among Japanese patients." | 7.83 | Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286 Japanese Workers. ( Fujibayashi, K; Fukuda, H; Hisaoka, T; Isonuma, H; Jose, PA; Matsuo, H; Miwa, Y; Naito, T; Nakayama, A; Sanada, H; Suzuki, A; Uehara, Y; Yokokawa, H, 2016) |
| "It is controversial that uric acid (UA) levels are related to the severity of hypertension in preeclampsia (PE)." | 7.83 | The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia. ( Aliciguzel, Y; Elmas, O; Simsek, T, 2016) |
| "Longitudinal changes in uric acid levels were independently associated with the renal function decline in elderly patients with hypertension." | 7.83 | Influence of changes in serum uric acid levels on renal function in elderly patients with hypertension: a retrospective cohort study with 3.5-year follow-up. ( Chen, H; Huang, F; Lin, C; Lin, F; Zhang, H; Zhu, P, 2016) |
| "Increased xanthine oxidase (XO) activity and uric acid levels are known to be associated with obesity and hypertension; however, it is not known if obesity is directly responsible for these associations in youth." | 7.83 | Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity. ( Fox, CK; Johnson, LA; Kelly, AS; Nathan, BM; Tam, HK, 2016) |
| "To investigate the related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia." | 7.83 | Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia. ( Lin, L; Wang, B; Zhao, C, 2016) |
| "In matched analysis, risk of ischaemic stroke increased by 15% for each 1 mg/dl increase in plasma uric acid [95% confidence interval (CI) 3%-28%], but was no longer significant after adjustment for cardiovascular risk factors, particularly history of hypertension." | 7.83 | Plasma uric acid concentrations and risk of ischaemic stroke in women. ( Choi, HK; Curhan, GC; Forman, JP; Jiménez, MC; Rexrode, KM, 2016) |
| " Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other known risk factors." | 7.83 | Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study. ( Cai, C; Feng, S; Li, WD; Shi, W; Sun, N; Tian, J; Wang, Y; Wei, F; Xu, W; Yang, X, 2016) |
| "Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS)." | 7.83 | Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study. ( Eriksen, BO; Jenssen, TG; Norvik, JV; Solbu, MD; Storhaug, HM; Ytrehus, K; Zykova, SN, 2016) |
| " To help understand the pathogenesis and early prevention of progressive CKD, this large-scale study is designed to determine the complex association between serum uric acid (SUA), metabolic syndrome and the prevalence of CKD in hypertensive patients." | 7.83 | Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients. ( Chen, R; Chen, Z; Dai, H; Liu, C; Lu, M; Lu, S; Lu, Y; Tang, X; Yang, P; Yuan, H; Zhou, H, 2016) |
| "Serum uric acid level is a predictor of future hypertension." | 7.83 | Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age. ( Kondo, T; Maeda, K; Murohara, T; Okumura, N; Osugi, S; Shimokata, K; Yokoi, Y, 2016) |
| " We evaluated the association between serum uric acid and uACR in persons with 0, and 1-2 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association." | 7.83 | The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome. ( Bruthans, J; Cifkova, R; Hamet, P; Krajcoviechova, A; Tahir, MR; Tremblay, J; Wohlfahrt, P, 2016) |
| "The purpose of this study was to examine the associations between serum uric acid (SUA) levels and the incidences of hypertension and metabolic syndrome (MetS) in a large screened cohort of Japanese men and women." | 7.81 | Associations between serum uric acid levels and the incidence of hypertension and metabolic syndrome: a 4-year follow-up study of a large screened cohort in Okinawa, Japan. ( Inoue, T; Kinjo, K; Kohagura, K; Nagahama, K; Ohya, Y, 2015) |
| "Serum uric acid (SUA) is associated with many cardiovascular risk factors such as hypertension (HTN) and metabolic syndrome (MetS)." | 7.81 | Serum uric acid levels are associated with hypertension and metabolic syndrome but not atherosclerosis in Chinese inpatients with type 2 diabetes. ( Bao, YQ; Dong, XH; Jia, WP; Li, LX; Li, MF; Li, TT; Shen, J; Zhang, R, 2015) |
| "Several studies have demonstrated a relationship between increased serum uric acid (SUA) concentrations and the prevalence of metabolic syndrome (MetS) in the oriental population." | 7.81 | Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study. ( Babio, N; Basora, J; Becerra-Tomás, N; Corella, D; Estruch, R; Fitó, M; Martínez-González, MA; Ortega-Calvo, M; Recondo, J; Ros, E; Salas-Salvadó, J; Serra-Majem, L; Wärnberg, J, 2015) |
| "The causal relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) has not yet been clarified." | 7.81 | Serum uric acid and non-alcoholic fatty liver disease in non-hypertensive Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study. ( Dou, LJ; Gong, Y; Liang, J; Liu, XK; Pei, Y; Qi, L; Qiu, QQ; Yang, MQ; Zou, CY, 2015) |
| "Inefficient renal excretion of uric acid is the main pathophysiological mechanism for hyperuricemia in gout patients." | 7.81 | Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients. ( Aniel-Quiroga, MA; Chinchilla, SP; Erauskin, GG; Herrero-Beites, AM; Merriman, T; Perez-Ruiz, F, 2015) |
| "The purpose of this study was to evaluate associations among hypertension (HTN) and uric acid (UA) with cardiovascular autonomic neuropathy (CAN), and to estimate the extent to which synergistic effects of HTN and UA affect the outcome in a Chinese population." | 7.81 | The association and interaction analysis of hypertension and uric acid on cardiovascular autonomic neuropathy. ( Liao, XP; Tang, ZH; Zeng, F; Zhu, HW, 2015) |
| " Linear regression was used to evaluate associations between uric acid and clinical and laboratory findings associated with metabolic syndrome." | 7.81 | [Metabolic complications of obesity during adolescence, particularly regarding elevated uric acid levels]. ( Almási, A; Barkai, L; Fehér, V; Kiss-Tóth, E; Ságodi, L, 2015) |
| "There are data describing that cardiovascular risks related to serum uric acid (SUA) levels may begin below the current diagnostic level for hyperuricemia." | 7.81 | Uric acid levels within the normal range predict increased risk of hypertension: a cohort study. ( Dinour, D; Holtzman, EJ; Leiba, A; Shani, M; Vinker, S, 2015) |
| "Uric acid (UA) is associated with high blood pressure in adolescents and with left ventricular hypertrophy (LVH) and cardiovascular disease (CVD) in adults." | 7.81 | Elevated uric acid and obesity-related cardiovascular disease risk factors among hypertensive youth. ( Appel, LJ; Brady, TM; Fadrowski, JJ; Holmes, KW; Loeffler, LF; Miller, ER; Reschke, LD, 2015) |
| "To explore the associations between urine uric acid excretion (UUAE) and diabetic retinopathy (DR)/lower limb atherosclerotic lesions in hospitalized Chinese patients with type 2 diabetes." | 7.81 | Decreased urine uric acid excretion is associated with diabetic retinopathy but not with lower limb atherosclerosis in hospitalized patients with type 2 diabetes. ( Bao, YQ; Chen, MY; Jia, WP; Li, LX; Li, TT; Lu, JX; Shuai, HP; Wang, JW; Xia, HF; Zhang, R, 2015) |
| "Serum uric acid (UA) is independently associated with hypertension and blood pressure (BP) variability (BPV) is associated with cardiovascular events and mortality in hypertensive patients." | 7.81 | Association of Serum Uric Acid Level With Blood Pressure Variability in Newly Diagnosed Essential Hypertension. ( Çağlı, K; Canpolat, U; Covic, A; Kanbay, M; Mendi, MA; Öksüz, F; Özcan, F; Siriopol, D; Tok, D; Turak, O; Veisa, G, 2015) |
| "The relationships between uric acid and chronic disease risk factors such as metabolic syndrome, type 2 diabetes mellitus, and hypertension have been studied in adults." | 7.81 | Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study. ( Chen, YL; Lue, KH; Pei, D; Sun, HL, 2015) |
| "Elevated serum uric acid (UA) could be a risk factor for hypertension, type 2 diabetes mellitus and cardiovascular disease." | 7.80 | Serum uric acid level is associated with the development of microalbuminuria in Korean men. ( Oh, CM; Park, SK; Ryoo, JH, 2014) |
| "Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance." | 7.80 | Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study. ( Borghi, C; Cicero, AF; D'Addato, S; Rosticci, M; Salvi, P, 2014) |
| "We assessed the effect of increased serum uric acid (SUA) concentration and hyperuricemia on subclinical organ damage." | 7.80 | Serum uric acid concentration and asymptomatic hyperuricemia with subclinical organ damage in general population. ( Li, Y; Lu, J; Wu, X; Yang, C, 2014) |
| "We tested the hypothesis that uric acid levels predict new-onset hypertension in the Japanese general population." | 7.80 | Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population. ( Dohi, Y; Kimura, G; Takase, H, 2014) |
| " Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD)." | 7.80 | Uric acid level and erectile dysfunction in patients with coronary artery disease. ( Akilli, H; Aribas, A; Covic, A; Gaipov, A; Johnson, RJ; Kanbay, M; Kayrak, M; McFann, K; Perez-Pozo, SE; Solak, Y; Turk, S, 2014) |
| " In the present study, blood triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) breakdown pathway was evaluated in relation to uric acid concentration and xanthine dehydrogenase/xanthine oxidase (XDH/XO) in patients with essential hypertension, patients with chronic renal diseases on dialysis, and control individuals." | 7.80 | Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease. ( Boban, M; Bobana, MD; Cvetkovic, T; Deljanin-Ilic, M; Djindjic, B; Ilic, S; Jevtovic-Stoimenov, T; Kocic, G; Pavlovic, R; Radenkovic, S; Sokolovic, D; Stojanovic, D, 2014) |
| "Serum uric acid (UA) is now beginning to be considered a risk predictor for cardiovascular diseases." | 7.80 | Serum uric acid as a risk predictor for erectile dysfunction. ( Heydari, R; Mehrsai, A; Pourmand, G; Salem, S, 2014) |
| " Despite evidence of uric acid-induced endothelial dysfunction, a relationship with insulin resistance has not been clearly established." | 7.80 | Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. ( Choi, YJ; Hien, TT; Kang, DH; Kang, KW; Kim, KC; Lee, BH; Lee, J; Lee, KY; Lee, MY; Lee, SM; Yoon, Y, 2014) |
| "The cause and effect relationship between serum uric acid levels and hypertension can be difficult to evaluate because antihypertensive drugs sometimes affect uric acid levels." | 7.80 | Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension. ( Asano, T; Hisatome, I; Komatsu, I; Kuwabara, M; Masuda, K; Mizuno, A; Nishi, Y; Niwa, K; Takahashi, O; Yamazoe, M, 2014) |
| "To assess the relationship between serum uric acid and target organ damage (left ventricular hypertrophy and microalbuminuria) in untreated patients with essential hypertension." | 7.80 | Serum uric acid and target organ damage in essential hypertension. ( Odia, OJ; Ofori, SN, 2014) |
| "The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients." | 7.80 | Prevention of comorbidity and acute attack of gout by uric acid lowering therapy. ( Joo, H; Joo, K; Jung, KH; Kwon, SR; Lim, MJ; Park, W, 2014) |
| "This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension." | 7.80 | Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension. ( Chen, B; Deng, W; Zhang, J; Zhang, Y, 2014) |
| "To evaluate whether uric acid (UA) predicts 4-yr incidence of metabolic syndrome (MetS) in non-diabetic participants of the Strong Heart Study (SHS) cohort." | 7.80 | Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity. ( de Simone, G; Devereux, RB; Ferrara, LA; Franceschini, N; Howard, BV; Jolly, S; Lee, ET; Umans, JG; Wang, H; Yeh, J, 2014) |
| "To identify the risk factors of kidney injuries in hypertensive patients with uric acid (UA) metabolic disorders in order to choose the optimal management tactics, by analyzing the changes in markers for endothelial dysfunction (endothelin-1 (ET-1), microalbuminuria (MAU), intima-media thickness (IMT)) and tubulointerstitial tissue lesion (beta2-microglobulin (beta2-MG, monocyte chemotactic protein-1 (MCP-1))." | 7.80 | [Clinical value of the determination of markers for endothelial dysfunction (endothelin-1, microalbuminuria) and tubulointerstitial tissue lesion (β2-microglobulin, monocyte chemotactic protein-1) in hypertensive patients with uric acid metabolic disorder ( Balkarov, IM; Kozlovskaia, LV; Shcherbak, AV; Stakhova, TIu; Taranova, MV, 2014) |
| "To elucidate links of blood serum uric acid level (SUAL) with cardiometabolic risk factors (CMR) in adolescent boys with arterial hypertension (AH)." | 7.80 | [Uric acid and factors of cardiometabolic risk in adolescents with arterial hypertension]. ( Dolgikh, VV; Pogodina, AV; Rychkova, LV, 2014) |
| " Of note, diabetic subjects with glycosuria, who represented 24% of the diabetic participants, had a null prevalence of hyperuricemia, and statistically higher values for fractional excretion of uric acid, Na excretion index, and prevalence of microalbuminuria than those without glycosuria." | 7.80 | Serum uric acid and disorders of glucose metabolism: the role of glycosuria. ( Andrade, JA; Garcia Rosa, ML; Greffin, S; Kang, HC; Lugon, JR, 2014) |
| "To study the correlation between lacunar cerebral infarction and level of serum uric acid in elderly male hypertension patients." | 7.80 | [Correlation between lacunar cerebral infarction and serum uric acid level in elderly male hypertension patients]. ( Cheng, L; Guan, WP; Jiang, L; Ma, Q; Wu, WP, 2014) |
| "We assessed whether red cell distribution width (RDW) is associated with serum uric acid (UA) level in a group of 512 patients with newly diagnosed hypertension, recruited in Beijing." | 7.80 | Relationship between red cell distribution width and serum uric acid in patients with untreated essential hypertension. ( Chen, LZ; Chen, P; Hu, YY; Li, YY; Li, ZZ; Luo, M; Yan, SP, 2014) |
| "Experimental and epidemiological studies have demonstrated that urinary angiotensinogen (AGT) is a novel biomarker for the intrarenal activity of the renin-angiotensin system in hypertension (HT)." | 7.79 | Urinary angiotensinogen as a marker of intrarenal angiotensin II activity in adolescents with primary hypertension. ( Kuroczycka-Saniutycz, E; Milewski, R; Sulik, A; Wasilewska, A, 2013) |
| "There is an ongoing debate on the role of serum uric acid as an independent risk factor for hypertension and renal disease." | 7.79 | Serum uric acid levels among Nigerians with essential hypertension. ( Abdu, A; Emokpae, AM, 2013) |
| "Uric acid (UA) is independently associated with the emergence of hypertension." | 7.79 | Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. ( Aydoğdu, S; Işleyen, A; Johnson, RJ; Kanbay, M; McFann, K; Ozcan, F; Sen, N; Sökmen, E; Taşoğlu, I; Tok, D; Turak, O, 2013) |
| "Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke." | 7.79 | Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke. ( Kim, BJ; Kim, CK; Lee, SH; Ryu, WS, 2013) |
| " Since low urine pH is the main risk factor for uric acid urolithiasis (UAU), UAU may be regarded as a renal manifestation of the MS." | 7.78 | Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. ( Schubert, G; Strohmaier, WL; Wrobel, BM, 2012) |
| " Overall serum uric acid (UA) concentration increased, whereas in patients with hyperuricemia there was a significant reduction in this value." | 7.78 | Antihypertensive effect of a fixed-dose combination of losartan/hydrochlorothiazide in patients with uncontrolled hypertension: a multicenter study. ( Akaba, K; Endo, S; Fukui, A; Gomi, H; Hamaguchi, A; Hanaoka, K; Hara, Y; Hasegawa, T; Hayakawa, H; Hayashi, F; Hikida, M; Hirano, K; Horiguchi, M; Hosoya, M; Hosoya, T; Ichida, K; Ikeda, M; Imai, T; Ishii, T; Ishikawa, H; Ishikawa, M; Kameda, C; Kanai, T; Kasai, T; Kawamura, T; Kobayashi, A; Kobayashi, H; Kurashige, M; Kuriyama, S; Kusama, Y; Maezawa, H; Maezawa, Y; Maruyama, Y; Matsuda, H; Matsuo, N; Matsuo, T; Miura, Y; Miyajima, M; Miyakawa, M; Miyazaki, Y; Mizuguchi, M; Morita, T; Nakao, M; Nokano, H; Ogura, M; Ohkido, I; Ohno, I; Ohtsuka, Y; Okada, K; Okamoto, H; Okonogi, H; Saikawa, H; Saito, H; Sekiguchi, C; Soejima, M; Suetsugu, Y; Sugano, N; Suzuki, T; Takahashi, H; Takahashi, Y; Takamizawa, S; Takane, K; Takazoe, K; Tanaka, H; Tanaka, S; Terawaki, H; Tokudome, G; Tomonari, H; Toyoshima, R; Tsuboi, N; Udagawa, T; Ueda, H; Ueda, Y; Uetake, M; Unemura, S; Utsunomiya, M; Utsunomiya, Y; Yamada, T; Yamada, Y; Yamaguchi, Y; Yamamoto, H; Yokoo, T; Yokoyama, K; Yonezawa, H; Yoshida, H; Yoshida, M; Yoshizawa, T, 2012) |
| "Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events." | 7.78 | Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: a Chinese cohort study. ( Bai, CH; Chien, KL; Chou, YC; Chu, CH; Hwang, LC; Su, TC; Sun, CA; Tseng, CH; Yang, T; You, SL, 2012) |
| "Serum uric acid (UA) plays a key role in the development and progression of hypertension." | 7.77 | Association of serum uric acid level with aortic stiffness and arterial wave reflections in newly diagnosed, never-treated hypertension. ( Aznaouridis, K; Baou, K; Bratsas, A; Dima, I; Lazaros, G; Stefanadis, C; Tzamou, V; Vlachopoulos, C; Vyssoulis, G; Xaplanteris, P, 2011) |
| "Uric acid is an independent predictor of diabetes in primary hypertension." | 7.77 | Serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the MAGIC study. ( Deferrari, G; Leoncini, G; Pontremoli, R; Vercelli, M; Viazzi, F, 2011) |
| "The data regarding the role of serum uric acid (SUA) along with subclinical inflammation in the context of hypertensive vascular damage are rather scarce and controversial." | 7.77 | The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. ( Dimitriadis, K; Katsi, V; Kyvelou, S; Lalos, S; Mihas, C; Poulakis, M; Sideris, S; Skiadas, I; Stefanadi, E; Stefanadis, C; Syrseloudis, D; Tsioufis, C, 2011) |
| "To study the relationship of dyslipidemia and serum uric acid with the risk of myocardial infarction among the hypertensive type 2 diabetic and non-diabetic patients of Trinidad." | 7.77 | Relationship of dyslipidemia and uric acid with the risk of myocardial infarction among hypertensive patients in Trinidad. ( Evernden, K; Fane, U; Fatt, LA; Maharaj, D; Maharaj, N; Maharaj, S; Maharaj, SS; Maharaj, V; Maloney, V; Nayak, BS, 2011) |
| "Indapamide(1 mg) was given daily for 3 months and was then given every other day for 3 months to patients whose hypertension was poorly controlled with angiotensin II receptor blocker (ARB)-based treatment." | 7.76 | Effects of additional administration of low-dose indapamide on patients with hypertension treated with angiotensin II receptor blocker. ( Kusunose, K; Mishiro, Y; Sata, M; Yamada, H, 2010) |
| "We investigated the effects of soluble uric acid (UA) on the development of hypertension in spontaneously hypertensive rats (SHRs), using Wistar-Kyoto rats (WKY) as normotensive controls." | 7.76 | Effect of uric acid on hypertension progression in spontaneously hypertensive rats. ( Chávez, M; Durante, P; Pérez, M; Rivera, F; Romero, F, 2010) |
| " We examined the association between uric acid levels and various clinical parameters, including the components of metabolic syndrome, in essential hypertension." | 7.76 | Association of uric acid with risk factors for chronic kidney disease and metabolic syndrome in patients with essential hypertension. ( Anzawa, R; Fujii, T; Seki, S; Tsutsui, K; Yamazaki, K; Yoshimura, M, 2010) |
| "Uric acid (UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome (MS)." | 7.76 | Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome. ( Chen, XF; Du, YX; Fang, CF; Jiang, JJ; Lin, XF; Pu, ZX; Tang, LJ; Wang, JA, 2010) |
| "The aim of the study was to investigate endothelial function in patients with arterial hypertension and impaired uric acid metabolism in comparison with patients having arterial hypertension and normal uric acid metabolism." | 7.76 | [Endothelial function in patients with arterial hypertension and impaired uric acid metabolism]. ( Lebedeva, MV; Minakova, EG; Pulin, AA; Severova, MM; Stakhova, TIu; Zaĭtseva, LI, 2010) |
| "Epidemiologic studies suggest an independent positive association of elevated serum uric acid with essential hypertension." | 7.75 | Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians. ( Chen, T; Dong, B; Lu, Z; Wu, H; Wu, J; Xiao, H; Zhang, Y, 2009) |
| "Uric acid, insulin sensitivity, and endothelial dysfunction may be important in the development of hypertension." | 7.75 | Uric acid and insulin sensitivity and risk of incident hypertension. ( Choi, H; Curhan, GC; Forman, JP, 2009) |
| "The aim of the study was to assess the association of serum uric acid levels with microalbuminuria -urinary albumin excretion (UAE)> or = 30mg/24h-." | 7.75 | Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients. ( Costa, JA; González, C; Miralles, A; Moral, D; Pascual, JM; Pérez-Lahiguera, F; Rodilla, E, 2009) |
| "Uric acid is heritable and associated with hypertension and insulin resistance." | 7.75 | Genome-wide linkage analysis for uric acid in families enriched for hypertension. ( Asmann, Y; Boerwinkle, E; Fridley, BL; Hunt, SC; Mosley, TH; Pankow, JS; Rule, AD; Turner, ST, 2009) |
| " We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults." | 7.75 | Serum uric acid and prehypertension among Chinese adults. ( Liang, J; Qi, L; Song, H; Xue, Y; Zhang, T; Zou, C, 2009) |
| "Uric acid (UA) is an emerging cardiovascular (CV) risk factor that is associated with hypertension and CV disease (CVD) in the general population, but whose role in renal transplant recipients (RTR) has not been defined." | 7.75 | Role of uric acid in post-renal transplantation hypertension. ( Bandukwala, F; Huang, M; Prasad, GV, 2009) |
| "Several studies have found that uric acid (UA) level is associated with an increased risk for hypertension, but the association could be confounded by metabolic factors that were not included in these previous studies." | 7.74 | Plasma uric acid level and risk for incident hypertension among men. ( Choi, H; Curhan, GC; Forman, JP, 2007) |
| "Experimental evidence supports a causal role of serum uric acid in hypertension development." | 7.74 | Association between serum uric acid and prehypertension among US adults. ( Li, J; Shankar, A; Syamala, S, 2007) |
| "The aim of this study was to examine whether serum uric acid (SUA) concentration was related to the metabolic syndrome (MS)." | 7.74 | Serum uric acid is significantly related to the components of the metabolic syndrome in Japanese workingmen. ( Katsumata, M; Kawada, T; Otsuka, T; Suzuki, H, 2007) |
| "The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation." | 7.74 | Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. ( Baumert, J; Döring, A; Koenig, W; Meisinger, C, 2008) |
| "The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study is a nationwide, prospective, multicentered, observational study that was designed to enroll 30,000 hypertensive Japanese patients from more than 3,000 private practitioners." | 7.74 | Efficacy and safety of long-term losartan therapy demonstrated by a prospective observational study in Japanese patients with hypertension: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study. ( Fujita, T; Ito, S; Naritomi, H; Ogihara, T; Shimada, K; Shimamoto, K; Tanaka, H; Yoshiike, N, 2008) |
| "Serum uric acid (UA) has been implicated in the pathogenesis of hypertension." | 7.73 | Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. ( D'Agostino, RB; Kannel, WB; Levy, D; Sullivan, L; Sundström, J; Vasan, RS, 2005) |
| "The levels of the liporegulatory hormone leptin are increased in obesity, which contributes to the metabolic syndrome; the latter is associated with elevated cardiovascular risk and morbidity." | 7.73 | Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans. ( Chraibi, A; Israili, ZH; Lyoussi, B; Mguil, M; Ragala, MA, 2005) |
| "To investigate if increased lipid peroxidation is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions." | 7.73 | Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats. ( Atarashi, K; Ishiyama, A; Minami, M; Omata, M; Takagi, M, 2005) |
| " The present study examined a Korean adult population with respect to the relationships between serum uric acid concentrations and hypertension, insulin resistance, and the risk factors of metabolic syndrome." | 7.73 | Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. ( Kang, JH; Keum, DG; Kim, BJ; Kim, BS; Kim, H; Kim, SW; Lee, MH; Lee, WY; Park, JR; Rhee, EJ; Ryu, SH; Shin, HS; Sung, KC; Yoo, TW, 2005) |
| "Apocynin but not allopurinol prevented and reversed ACTH-induced hypertension in the rat." | 7.73 | Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat. ( Andrews, MC; Chan, MM; Croft, KD; McKenzie, KU; Mori, TA; Schyvens, CG; Whitworth, JA; Zhang, Y, 2005) |
| "Uric acid (UA) may play a pathogenetic role in hypertension and kidney disease." | 7.73 | Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients? ( Armstrong, KA; Campbell, SB; Hawley, CM; Isbel, NM; Johnson, DW, 2005) |
| "The association between serum uric acid (UA) and the prevalence of hypertension, and the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphism and hypertension remains unclear." | 7.73 | Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men. ( Date, C; Lwin, H; Saito, K; Tanaka, H; Yamamoto, A; Yokoyama, T; Yoshiike, N, 2006) |
| "Elevated serum uric acid (UA) is frequently encountered in individuals with hypertension, but whether the relationship between UA and cardiovascular events is circumstantial or causal remains to be answered." | 7.73 | Uric acid, left ventricular mass index, and risk of cardiovascular disease in essential hypertension. ( Horio, T; Iwashima, Y; Kamide, K; Kawano, Y; Ogihara, T; Rakugi, H, 2006) |
| "The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke." | 7.73 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. ( Bos, MJ; Breteler, MM; Hofman, A; Koudstaal, PJ; Witteman, JC, 2006) |
| "The aim of the present study was to determine whether sex differences contribute to the association of serum uric acid and left ventricular hypertrophy in individuals with hypertension." | 7.73 | Gender-related association of serum uric acid and left ventricular hypertrophy in hypertension. ( Fujii, K; Iida, M; Matsumura, K; Ohtsubo, T; Oniki, H, 2006) |
| "To study effects of uric acid disbolism in combination with other metabolic disturbances on prevalence and clinical symptoms of arterial hypertension; contribution of uric acid nephropathy to its development." | 7.73 | [Relationships between arterial hypertension, metabolic disturbances and uric acid nephropathy]. ( Balkarov, IM; Britov, AN; Deev, AD; Eliseeva, NA, 2006) |
| "Increasing experimental evidence, including recently developed animal models support a causal role for uric acid in the development of hypertension." | 7.73 | The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study. ( Klein, BE; Klein, R; Nieto, FJ; Shankar, A, 2006) |
| "Serum uric acid has been positively associated with incident hypertension, but previous studies have had limited ability to explore this relationship across sex and ethnic strata." | 7.73 | Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. ( Bleyer, AJ; Erlinger, TP; Evans, GW; Herrington, DM; Mellen, PB; Nieto, FJ; Wagenknecht, LE; Wofford, MR, 2006) |
| "Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension." | 7.73 | Uric acid and the development of hypertension: the normative aging study. ( Gaziano, M; Gumieniak, O; Litonjua, AA; Perlstein, TS; Sparrow, D; Vokonas, PS; Weiss, ST; Williams, GH, 2006) |
| "Uric acid and oxidative stress promote cardiovascular diseases, including atherosclerosis and hypertension." | 7.73 | Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats. ( Hamada, T; Hisatome, I; Igawa, G; Igawa, O; Kaetsu, Y; Matsubara, K; Matsuura, T; Miake, J; Ogino, K; Shigemasa, C; Sugihara, S; Yamamoto, T; Yamamoto, Y; Yoshida, A, 2006) |
| "We examined the association of serum uric acid (SUA) with development of hypertension (blood pressure > or = 140/90 mmHg and/or medication for hypertension) and impaired fasting glucose (IFG) (a fasting plasma glucose level 6." | 7.72 | Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. ( Matsuo, Y; Nakanishi, N; Okamoto, M; Suzuki, K; Tatara, K; Yoshida, H, 2003) |
| "Body weight and BP decreased significantly in the diet group but not in the troglitazone group at the end of the intervention periods." | 7.71 | Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. ( Kamide, K; Kawano, Y; Minami, J; Tsunoda, S, 2002) |
| "To investigate the association of serum uric acid level with the risk for hypertension and Type 2 diabetes." | 7.71 | Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey. ( Endo, G; Fujii, S; Hayashi, T; Okada, K; Taniguchi, Y; Tsumura, K, 2001) |
| "To analyse relationships between left ventricular myocardium mass (LVMM) and imbalance of uric acid metabolism in patients with arterial hypertension (AH)." | 7.71 | [Relationship between mass of the left ventricular myocardium and uric acid metabolic imbalance in patients with arterial hypertension]. ( Anikina, SA; Balkarov, IM; Donskov, AS; Feofanova, ID; Golub', GV; Prilepo, NA; Saltykova, NG; Sviderskaia, NS, 2001) |
| "Our data suggest that there is a strong, independent association between familial occurrence of hypertension and the phenotype characterized by combined elevation of both urinary uric acid and calcium excretions." | 7.71 | High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension. ( Bull, SB; Honey, JD; Logan, AG; Pierratos, A; Rosivall, L; Tisler, A, 2002) |
| "The aim of our study was to estimate the serum levels of glucose, insulin, C-peptide and uric acid in patients with psoriasis before and after treatment." | 7.71 | [Evaluation of glucose, insulin, C-peptide uric acid serum levels in patients with psoriasis]. ( Fafara, I; Grzybowski, G; Wierusz-Wysocka, B; Zaba, R, 2001) |
| "Our purpose was to evaluate the clinical utility of serum uric acid measurements in the hypertensive diseases of pregnancy." | 7.70 | The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. ( Ecker, JL; Friedman, SA; Kao, L; Kilpatrick, SJ; Lim, KH, 1998) |
| "An elevated red blood cell (RBC) sodium-lithium countertransport (Na-Li CT) is associated with high blood pressure (BP) in cross-sectional investigations; however, its value as a predictor of future hypertension, and thus of cardiovascular risk, has not been defined." | 7.70 | Red blood cell sodium-lithium countertransport and risk of future hypertension: the Olivetti Prospective Heart Study. ( Cappuccio, FP; Farinaro, E; Iacone, R; Ragone, E; Russo, L; Siani, A; Strazzullo, P; Trevisan, M, 1998) |
| "To investigate the incidence of gout and the interaction between uric acid level and other risk factors in the development of gout." | 7.70 | The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. ( Chou, P; Lin, HY; Lin, KC, 2000) |
| "Our purpose was to evaluate the clinical utility of serum uric acid measurements in the hypertension diseases of pregnancy." | 7.70 | The clinical utility of serum uric acid measurements in pre-eclampsia and transient hypertension in pregnancy. ( Baviera, G; D'Anna, R; Leo, R; Leonardi, I; Scilipoti, A, 2000) |
| "The question of serum uric acid as an independent risk factor in subjects with essential hypertension remains controversial." | 7.70 | Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. ( Brunetti, P; Porcellati, C; Reboldi, G; Santeusanio, F; Schillaci, G; Verdecchia, P, 2000) |
| "Cyclosporine for microemulsion has been widely used in the treatment of rheumatoid arthritis (RA) with remarkably good results over progression of joint damage, as reported by the GRISAR Study." | 7.70 | [Efficacy, tolerability and safety of cyclosporine for microemulsion in the treatment of active rheumatoid arthritis. Open study]. ( Battagliotti, C; Díaz, EA; Garsd, A; Grosman, H; Gutfraind, E; Maccagno, A; Maldonado Cocco, J; Marcos, JC; Messina, DO; Onetti, CM; Otero, AB; Tate, G; Venarotti, HO, 2000) |
| "The association between serum uric acid and hypertension was evaluated in a sample of male workers in southern Italy enrolled in the Olivetti Heart Study, an ongoing longitudinal epidemiological investigation on risk factors for coronary heart disease carried out at the Olivetti factory in the suburban area of Naples." | 7.69 | Serum uric acid and hypertension: the Olivetti heart study. ( Celentano, E; Farinaro, E; Galasso, R; Jossa, F; Krogh, V; Mancini, M; Panico, S; Trevisan, M, 1994) |
| "The present study aimed to assess the influence of a highly industrialized environment on the prevalence of arterial hypertension and plasma levels of cholesterol, uric acid, aldosterone and plasma renin activity." | 7.69 | Does industrial environment influence the prevalence of arterial hypertension, plasma cholesterol and uric acid concentration and activity of the renin-aldosterone system? ( Kokot, F; Wiecek, A, 1996) |
| "The objective was to analyse the levels of uric acid in the hypertensive disorders of pregnancy." | 7.69 | [Variations in the uric acid levels in pregnancy hypertension]. ( Rojas-Ruiz, A; San Martín-Herrasti, JM; Vital-Terán, L, 1997) |
| "8 yrs old, with untreated mild essential hypertension, serum uric acid, total cholesterol triglycerides and glucose were examined at 8 a." | 7.69 | [Serum levels of uric acid, lipids and glucose in essential hypertension]. ( Bogdanovska, S; Lozance, Lj; Masin-Paneva, J; Zafirovska, K, 1996) |
| "The aim of the present study was to evaluate the relationship of C-peptide and the C-peptide/bloodsugar ratio with clinical/biochemical variables presenting a well-known association with insulin resistance in NIDDM patients in acceptable control, obtained without the use of exogenous insulin." | 7.69 | Relationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients. ( Acosta, D; Astorga, R; García de Pesquera, F; Losada, F; Morales, F; Pumar, A; Relimpio, F, 1997) |
| "Serum uric acid and oxypurines (hypoxanthine and xanthine) renal excretion of uric acid and oxypurines as well as plasma adenosine deaminase activity and AMP deaminase activity were studied in 18 patients with essential hypertension and in 17 healthy subjects." | 7.68 | [Value of oxypurines and uric acid in plasma, renal excretion of oxypurines and uric acid as well as plasma adenosine deaminase and AMP deaminase activity in patients with essential hypertension]. ( Banaszak, F; Głuszek, J; Tykarski, A, 1993) |
| "In order to know if abnormalities of calcium metabolism may be involved in the pathophysiology of pregnancy-induced hypertension (PIH), as it has been incriminated in essential hypertension, we measured plasma and urinary calcium and phosphate as well as plasma PTH and free calcitriol index (ratio of total calcitriol on the D binding protein) in normotensive pregnant women (n = 25), in women with PIH after the same duration of amenorrhea (> 28 wk, n = 21:preeclampsia and 20 transient hypertensions), and in age-matched nonpregnant women (n = 15)." | 7.68 | Calcium metabolism, plasma parathyroid hormone, and calcitriol in transient hypertension of pregnancy. ( Bouillon, R; el Esper, N; Fournier, A; Jans, I; Lalau, JD, 1993) |
| "Long-term efficacy and safety of the beta1-selective adrenoceptor-blocking agent bisoprolol was investigated in 164 patients with mild to moderate essential hypertension who had already been treated successfully with bisoprolol once daily for 1 year in preceding studies." | 7.68 | Three years of experience with bisoprolol in the treatment of mild to moderate hypertension. ( Buchner-Möll, D; Giesecke, HG, 1990) |
| "Serial estimations of platelet angiotensin II binding were made in two patients with hypertension developing in the third trimester of pregnancy." | 7.68 | Serial measurements of platelet angiotensin II binding in two patients with hypertension in pregnancy: case reports. ( Baker, PN; Broughton Pipkin, F, 1992) |
| "In patients with healthy native kidneys, long-term cyclosporine therapy, even at a low dose (5 mg/kg per day), is nephrotoxic and is associated with a high incidence of hypertension." | 7.68 | Renal function and blood pressure in patients receiving long-term, low-dose cyclosporine therapy for idiopathic autoimmune uveitis. ( Aupetit, B; Baumelou, A; Benhmida, M; Deray, G; Jacobs, C; Le Hoang, P; Maksud, P, 1992) |
| "This study was conducted to elucidate renal uric acid metabolism in patients with primary aldosteronism (PA;16 cases) as compared with normotensive subjects (NT;25 cases) and essential hypertensives (EHT;51 cases)." | 7.68 | [Study on uric acid metabolism in patients with primary aldosteronism]. ( Iimura, O; Kikuchi, K; Komura, H; Marusaki, S; Namba, M; Ohtomo, T; Satoh, N; Suzuki, S; Takada, T, 1992) |
| " To evaluate proximal tubular resorption and its relationship with erythrocyte cation transport systems that are known to be abnormal in essential hypertension, we measured fractional excretion of endogenous uric acid (FE Ur%) and exogenous lithium (FE Li%), erythrocyte sodium concentration, Na-K pump, Na-K cotransport and Li-Na countertransport in two groups of kidney transplant recipients with normal kidney function (creatinine less than 1." | 7.68 | Mechanisms of cyclosporine-induced hypertension. ( Barlassina, C; Bianchi, G; Cusi, D; Elli, A; Niutta, E; Quarto di Palo, F, 1991) |
| "The present study aimed to elucidate the role of renal dopaminergic and prostaglandin (PG) systems in renal uric acid metabolism in essential hypertension." | 7.68 | [The role of the renal dopaminergic and the prostaglandin systems in renal uric acid metabolism in patients with essential hypertension]. ( Hasegawa, T; Iimura, O; Kikuchi, K; Komura, H; Marusaki, S; Nanba, M; Ohtomo, T; Satoh, N; Suzuki, S; Takada, T, 1991) |
| "In forty patients with mild to moderate essential hypertension and in twenty healthy subjects serum uric acid was measured and parameters of renal excretion of urate were evaluated." | 7.68 | [Uric acid and arterial hypertension. I. Relation between serum uric acid level and its renal excretion in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "In forty patients with mild to moderate essential hypertension correlation between serum uric acid as well as renal excretion of urate and the transport of uric acid in nephron was evaluated." | 7.68 | [Uric acid and arterial hypertension. II. Evaluation of uric acid transport in the nephrons in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "In sixteen patients with moderate essential hypertension the effects of 10-day nifedipine treatment on serum uric acid and renal excretion of uric acid were evaluated." | 7.68 | [Uric acid and arterial hypertension. III. Effect of nifedipine on serum uric acid level and its renal excretion in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "Plasma values of atrial natriuretic factor (ANF) were evaluated in 31 women with pregnancy-induced hypertension (PIH) and 31 normal pregnant women at the same age of gestation." | 7.68 | Plasma concentrations of atrial natriuretic factor and hemodynamics in pregnancy-induced hypertension. ( Ambrosioni, E; Borghi, C; Boschi, S; Cassani, A; Contarini, A; Crippa, S; Marlettini, MG; Morselli-Labate, AM; Orlandi, C; Ricci, C, 1991) |
| "In forty patients with essential hypertension correlation between serum uric acid and some clinical features of hypertensive disease i." | 7.68 | [Uric acid and arterial hypertension. IV. Relation between serum uric acid level, the extent of vascular changes and heart enlargement in primary arterial hypertension]. ( Oko-Sarnowska, Z; Skołuda, A; Tykarski, A, 1991) |
| "We reviewed the clinical features and uric acid metabolism in 37 female patients with gout." | 7.68 | Female gout. Clinical spectrum and uric acid metabolism. ( Capitán, CF; de Miguel, E; Gijón, JB; Jiménez, ML; Mateos, FA; Michán, AD; Pérez de Ayala, C; Puig, JG, 1991) |
| "The authors examined the plasma renin activity (PRA), serum uric acid and creatinine in 53 patients with essential hypertension (EH)." | 7.68 | [Plasma renin activity, creatinine and uric acid in the serum of patients with essential hypertension]. ( Mechír, J; Pjescák, M; Rajnová, E; Suchmanová, I; Tkácová, R, 1990) |
| "The effect of verapamil on different metabolic parameters has been studied after changing the treatment of hypertension from hydrochlorothiazide to verapamil monotherapy." | 7.67 | Metabolic parameters after changing from hydrochlorothiazide to verapamil treatment in hypertension. ( Gordin, A; Lehtonen, A, 1984) |
| "Changes in serum lipids, apolipoproteins, and lipoproteins including high-density lipoprotein (HDL) subfractions following administration of captopril in patients with hypertension were studied." | 7.67 | Effect of captopril on high-density lipoprotein subfractions in patients with mild to moderate essential hypertension. ( Arakawa, K; Sasaki, J, 1989) |
| "Maximum serum uric acid (SUA) levels during the third trimester of pregnancy were selected in 215 hypertensive pregnant women: 100 with mild preeclampsia (PE), 25 with severe PE, 70 with essential hypertension (EH) and 20 with EH with superimposed PE (EH + PE)." | 7.67 | Uric acid levels: a useful index of the severity of preeclampsia and perinatal prognosis. ( Darbon-Grosso, HA; Illia, R; Imaz, FU; Margulies, M; Voto, LS, 1988) |
| "The long-term efficacy and tolerance of spironolactone in essential hypertension was evaluated among 20,812 patients referred to the Broussais and St." | 7.67 | Efficacy and tolerance of spironolactone in essential hypertension. ( Charru, A; Chatellier, G; Corvol, P; DeVries, C; Jeunemaitre, X; Kreft-Jais, C; Menard, J; Plouin, PF, 1987) |
| "Interaction of thiazide diuretics and the serum uric acid and creatinine levels was studied in 3693 stepped care participants in the Hypertension Detection and Follow-up Program not receiving treatment at baseline." | 7.67 | Is thiazide-produced uric acid elevation harmful? Analysis of data from the Hypertension Detection and Follow-up Program. ( Blaufox, MD; Borhani, NO; Curb, JD; Langford, HG; Molteni, A; Pressel, S; Schneider, KA, 1987) |
| "Plasma renin activity (PRA), plasma aldosterone (PA), blood uric acid (BUA), plasma concentrations of catecholamines (Pcat) and plasma volume (PV) were measured simultaneously in 24 patients with pregnancy-induced hypertension." | 7.67 | Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension. ( Boulanger, JC; Carayon, A; Coevoet, B; Comoy, E; de Fremont, JF; Demory, JE; Desailly, I; Fievet, P; Pleskov, L; Verhoest, P, 1985) |
| "A single-blind study was carried out in 22 out-patients with mild to moderate hypertension to investigate the effects of piretanide capsules on systolic and diastolic blood pressure during standardized ergometric and isometric exercise." | 7.67 | The effects of piretanide capsules on blood pressure during ergometric and isometric work loads in patients with mild to moderate essential hypertension. ( Maass, L; Meywald, W; Rangoonwala, B; Verho, M, 1985) |
| "The serum uric acid level varies during pregnancy." | 7.67 | [Blood uric acid and arterial hypertension in pregnancy. Interpretation and prognostic value]. ( Bonhomme, J; Dagousset, P, 1985) |
| "Plasma renin activity (PRA), plasma aldosterone (PA), blood uric acid (BUA), plasma concentrations of catecholamines (Pcat) and plasma volume (PV) were measured simultaneously in 24 patients with pregnancy-induced hypertension (PIH)." | 7.66 | Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension. ( Boulanger, JC; Carayon, A; Coevoet, B; Comoy, E; de Fremont, JF; Demory, JE; Desailly, I; Fievet, P; Pleskov, L; Verhoest, P, 1983) |
| "A prospective longitudinal study was conducted, looking at the changes in serum uric acid during pregnancy in women who were normotensive at initial presentation." | 7.66 | Serum uric acid as a marker of pregnancy-induced hypertension. ( Hickman, PE; Michael, CA; Potter, JM, 1982) |
| "The association of serum uric acid (SUA) with hypertension, ischemic ECG change, diabetes mellitus, and drinking and smoking habits was studied by multivariate analysis among 1871 residents aged 40 and over in Hisayama, Japan." | 7.66 | The relationship of serum uric acid to hypertension and ischemic heart disease in Hisayama population, Japan. ( Hirota, Y; Okada, M; Omae, T; Takeshita, M; Ueda, K, 1982) |
| "Intrarenal handling of uric acid was studied in 12 patients with essential hypertension under spironolactone treatment (200 mg/day)." | 7.66 | Changes in intrarenal uric acid handling during chronic spironolactone treatment in patients with essential hypertension. ( Boer, P; Dorhout Mees, EJ; Peuker, KH; Roos, JC, 1982) |
| "Serum uric acid concentrations and the fractional excretion of uric acid were determined in 31 children from 3 1/2 to 18 years of age with essential hypertension." | 7.66 | Uric acid in childhood essential hypertension. ( Baluarte, HJ; Gruskin, AB; Polinsky, MS; Prebis, JW, 1981) |
| "Male and female, Sprague-Dawley rats, with and without arteriosclerosis, were subjected to chronic treatment with furosemide for 4 weeks." | 7.66 | Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats. ( Wexler, BC, 1981) |
| "The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension." | 7.66 | A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980) |
| "Fifty-two middle-aged patients with essential hypertension were treated for five months with 25 mg mefruside as the only antihypertensive drug." | 7.66 | Effects of mefruside treatment in hypertension. ( Bergengren, B; Henningsen, NC; Malmborg, O; Pihl, O; Renmarker, K; Strand, L, 1980) |
| "The authors have carried out research in 58 cases to see whether the findings of high uric acid levels in the blood are of prognostic value in all cases of arterial hypertension in pregnancy whatever the aetiology." | 7.66 | [The prognostic value of raised uric acid in the blood in arterial hypertension in pregnancy. 58 cases (author's transl)]. ( Cotteel, M; Delecour, M; Dequiedt, P; Leroy, JL; Potier, A; Puech, F; Tacquet, A, 1979) |
| "Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension." | 7.66 | Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study. ( Helgeland, A; Hjermann, I; Holme, I; Leren, P, 1978) |
| "To study whether the renin-angiotensin system is related to hyperuricemia in hypertension, the serum concentration of uric acid was determined in 96 patients with various types of hypertension and various degrees of plasma renin activity (PRA)." | 7.66 | Serum uric acid and the renin-angiotensin system in hypertension. ( Kato, E; Kondo, K; Nakamura, R; Oguro, T; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978) |
| "Azelnidipine was administered to 72 patients at a daily dose of 8 mg or 16 mg." | 6.79 | Effects of azelnidipine on uric acid metabolism in patients with essential hypertension. ( Cheng, J; Hamada, T; Hirata, S; Hisatome, I; Igawa, O; Kato, M; Kuwabara, M; Miyazaki, S; Mizuta, E; Moriwaki, Y; Ninomiya, H; Nosaka, Y; Ogino, K; Ohtahara, A; Yamamoto, K; Yamamoto, Y; Yoshida, A, 2014) |
| " Although blood levels of potassium, hemoglobin A1c and uric acid (UA) significantly increased after 3 months for all of the patients, none of the patients showed serious adverse effects." | 6.77 | Efficacy and safety of a single-pill fixed-dose combination of high-dose telmisartan/hydrochlorothiazide in patients with uncontrolled hypertension. ( Arimura, T; Fujisawa, K; Inoue, A; Kuwano, T; Matsunaga, E; Mitsutake, R; Miura, S; Morii, J; Nagata, I; Norimatsu, K; Saku, K; Shiga, Y; Shimizu, T; Shirotani, T; Uehara, Y, 2012) |
| "Many patients with hypertension have difficulty achieving their target blood pressure (BP)." | 6.77 | Efficacy and effect on plasma B-type natriuretic peptide concentration of losartan-hydrochlorothiazide for hypertension uncontrolled by losartan-based therapy: subanalysis of a Multicentre Prospective Observational Study. ( Inou, T; Kobayashi, K; Kubara, I; Meno, H; Nakamura, Y; Ota, T; Shiga, Y; Tanaka, M; Tsuchiya, Y, 2012) |
| " There were no significant differences in the incidences of clinical and laboratory drug-related adverse events between any of the combination groups and the placebo group." | 6.73 | Antihypertensive efficacy and safety of fixed-dose combination therapy with losartan plus hydrochlorothiazide in Japanese patients with essential hypertension. ( Hirayama, Y; Matsuoka, H; Nonaka, K; Ogihara, T; Saruta, T; Suzuki, H; Takahashi, K; Toki, M, 2007) |
| " The most commonly reported adverse events are dizziness, headache, fatigue, upper respiratory tract infection and urinary tract infection." | 6.72 | Evaluating the Safety and Tolerability of Azilsartan Medoxomil Alone or in Combination With Chlorthalidone in the Management of Hypertension: A Systematic Review. ( Antonopoulos, AS; Katsi, V; Michalakeas, C; Soulaidopoulos, S; Tousoulis, D; Tsioufis, K; Vlachopoulos, C, 2021) |
| "A total of 422 patients with type 2 diabetes who were hypertensive [sitting systolic blood pressure (SBP) > or = 140 mmHg and/or diastolic blood pressure (DBP) > or = 90 mmHg] and microalbuminuric [urinary albumin excretion (UAE) 30-300 mg/day] were eligible for the study." | 6.70 | Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics. ( Aznar, J; Llisterri, JL; Lozano, JV; Redon, J, 2001) |
| "Losartan has been shown to increase urinary uric acid excretion and hence to lower serum uric acid levels." | 6.70 | Comparative effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricaemia and gout. ( Brunner, HR; Burnier, M; Chiolero, A; Fallab-Stubi, CL; Gerster, JC; Maillard, M; Würzner, G, 2001) |
| " A dose-response relationship to losartan was observed in this patient population." | 6.68 | Effects of losartan on a background of hydrochlorothiazide in patients with hypertension. ( Goldberg, AI; Pratt, JH; Soffer, BA; Sweet, CS; Wiens, B; Wright, JT, 1995) |
| "In contrast, hyperinsulinemia caused a significant decrease in the urinary excretion of uric acid (2." | 6.68 | Effect of insulin on renal sodium and uric acid handling in essential hypertension. ( Bianchi, S; Bigazzi, R; Ciociaro, D; Ferrannini, E; Frascerra, S; Galvan, AQ; Muscelli, E; Natali, A; Sironi, AM, 1996) |
| " The acute pharmacodynamic actions of intravenous (i." | 6.67 | Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. ( Berman, RS; Bradstreet, DC; Jallard, N; Saenz, A; Sweet, CS; Weidler, DJ, 1994) |
| "Bendroflumethiazide 5 mg was given to 17 patients with essential hypertension who had persistent mild to moderate hypertension despite treatment with nifedipine slow-release tablets 20 mg bid." | 6.66 | The effects of bendroflumethiazide added to nifedipine in patients with hypertension. ( Beevers, DG; Gill, JS; Zezulka, AV, 1987) |
| "Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage." | 6.65 | Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983) |
| " They received in random order: placebo; tienilic acid 250 mg/day; propranolol 80 mg twice daily; and tienilic acid 250 mg/day combined with propranolol 80 mg twice daily." | 6.65 | Biochemical and haematological changes induced by tienilic acid combined with propranolol in essential hypertension. ( Bulpitt, CJ; Havard, CW; Pearson, RM, 1979) |
| "Hyperuricemia affects one out of five adults as a result of the Western diet, insulin resistance, and renal dysfunction." | 6.61 | Uric acid and hypertension: a focused review and practical recommendations. ( Borghi, C; Burnier, M; De Becker, B; van de Borne, P, 2019) |
| "Uric acid is a waste product of purine catabolism." | 6.49 | Uric acid as a danger signal in gout and its comorbidities. ( Kataoka, H; Lai, JJ; Rock, KL, 2013) |
| "Uric acid is a major product of purine metabolism in humans." | 6.46 | Uric acid and the development of hypertension. ( Hwu, CM; Lin, KH, 2010) |
| "Calcium antagonists are used in the treatment of hypertension and angina." | 6.44 | The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension. ( Coca, A; Sierra, C, 2008) |
| "Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system." | 6.44 | Uric acid: bystander or culprit in hypertension and progressive renal disease? ( Menè, P; Punzo, G, 2008) |
| "Hypertension is the most common form of cardiovascular disease." | 6.43 | Uric acid and hypertension in adolescents. ( Feig, DI, 2005) |
| "Uric acid may increase as a result of pathophysiological processes such as impaired renal sodium handling but may also contribute to renal and vascular damage, particularly endothelial dysfunction." | 6.43 | Uric acid and hypertension. ( Schachter, M, 2005) |
| "Hyperuricemia has long been known to be associated with cardiovascular disease, and it is particularly common in people with hypertension, metabolic syndrome, or kidney disease." | 6.43 | Role of uric acid in hypertension, renal disease, and metabolic syndrome. ( Heinig, M; Johnson, RJ, 2006) |
| "Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events." | 6.42 | Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? ( Feig, D; Herrera-Acosta, J; Johnson, RJ; Kanellis, J; Kang, DH; Kivlighn, S; Mazzali, M; Rodriguez-Iturbe, B; Tuttle, KR; Watanabe, S, 2003) |
| "Indapamide SR 1." | 6.41 | Metabolic profile of indapamide sustained-release in patients with hypertension: data from three randomised double-blind studies. ( Weidmann, P, 2001) |
| "Gender-based evidence on the association between serum uric acid (SUA) and left ventricular hypertrophy (LVH), as assessed by echocardiography, is still based on single studies." | 5.94 | Uric acid and left ventricular hypertrophy: a gender-based meta-analysis of echocardiographic studies. ( Carugo, S; Cuspidi, C; Faggiano, A; Gherbesi, E; Grassi, G; Sala, C; Tadic, M, 2024) |
| " Obesity, lipids, glucose tolerance and insulin resistance are risk factors for numerous cardiovascular diseases and are often accompanied by a considerable increase in serum uric acid (SUA) concentrations." | 5.94 | Insights into the relationship between serum uric acid and pulmonary hypertension (Review). ( Chen, M; He, Y; Lei, W; Luo, H; Shui, X; Zheng, J; Zhou, Y, 2024) |
| "Uric acid (UA) is an independent prognostic factor for cardiovascular events, but there are no data demonstrating a different risk profile between women and men." | 5.91 | Sex-related differences for uric acid in the prediction of cardiovascular events in essential hypertension. A population prospective study. ( Andreozzi, F; Caroleo, B; Gigliotti, S; Maio, R; Perticone, F; Perticone, M; Sciacqua, A; Shehaj, E; Suraci, E, 2023) |
| " The potential risk factors for the discontinuation events caused by sac/val-related adverse events (AEs) were explored." | 5.72 | Effectiveness and safety of sacubitril/valsartan for patients with hypertension and heart failure in the real-world setting: A retrospective study in China. ( Chen, C; Fan, L; Li, J; Li, X; Lv, Q; Tian, D; Zuo, C, 2022) |
| " In addition, the dose-response curve was also used to discuss the relationship between SUA and pSS-HT." | 5.72 | Relationship between serum uric acid and hypertension in patients with primary Sjögren's syndrome: A retrospective cohort study. ( Luo, Q; Qin, L; Wang, H; Yang, X; Zhang, Y, 2022) |
| " The dose-response relationship of SUACr and MetS was further assessed by a restricted cubic spline model (RCS)." | 5.72 | Association of the serum uric acid to creatinine ratio with metabolic syndrome in the middle age and older population in China. ( Guo, Y; Huang, H; Huang, S; Li, L; Liu, D; Wu, F; Zhong, D, 2022) |
| "Our study demonstrated the efficiency of benzbromarone in hypertensive patients with concomitant asymptomatic hyperuricemia, including the benefits on ameliorating LV diastolic dysfunction as well as improving composite endpoints." | 5.69 | Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function. ( Gu, J; Han, Z; Ke, J; Lin, H; Pan, J, 2023) |
| " The aim of this study was to determine whether urate-lowering therapy with an XO inhibitor (febuxostat) and that with a uricosuric drug (benzbromarone) are comparable in slowing renal function decline in patients with CKD complicated with hypertension and hyperuricemia." | 5.69 | Urate-lowering drugs for chronic kidney disease with asymptomatic hyperuricemia and hypertension: a randomized trial. ( Arima, H; Funakoshi, R; Iseki, K; Ishida, A; Kinjyo, K; Kochi, M; Kohagura, K; Nakamura, T; Ohya, Y; Sakima, A; Satoh, A; Tana, T; Yamazato, M; Zamami, R, 2023) |
| "Hyperuricemia was common in youth with T2D." | 5.51 | Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu ( Bjornstad, P; El Ghormli, L; Laffel, L; Lynch, J; Nadeau, KJ; Tollefsen, SE; Weinstock, RS, 2019) |
| "Whether hyperuricemia is an independent risk factor for hypertension in adults is still under debate." | 5.46 | Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort. ( Cui, LF; Han, YX; Liu, N; Mu, R; Shi, HJ; Shu, R; Song, HC; Sun, K; Wang, GY; Wang, J; Wang, JR; Wu, SL; Yang, WH; Yu, P; Zhou, B, 2017) |
| "Metabolic syndrome was defined according to the Adult Treatment Panel III criteria modified for children and adolescents." | 5.43 | Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study. ( Asayesh, H; Djalalinia, S; Eslami Shahr Babaki, A; Heshmat, R; Kelishadi, R; Motlagh, ME; Qorbani, M; Safari, O; Safiri, S; Tajadini, MH; Tajbakhsh, R, 2016) |
| "In the present study, 841 NAFLD males (30-75 years) were recruited from a Chinese prospective cohort study (PMMJS) and followed up for five years." | 5.43 | Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males. ( Dong, C; Guo, Z; Liu, C; Qiu, J; Song, K; Wang, Y; Xu, Y; Zhang, B; Zhou, H; Zhou, Z, 2016) |
| "Early detection diabetic nephropathy (DN) is important." | 5.43 | Serum uric acid and its association with hypertension, early nephropathy and chronic kidney disease in type 2 diabetic patients. ( Fathy, H; Fouad, M; Zidan, A, 2016) |
| "Hyperuricemia is an independent risk factor for hypertension." | 5.42 | Does elevated serum uric acid level predict the hypertension incidence? A Chinese prospective cohort study. ( Gao, Y; Huang, J; Li, Y; Niu, K; Sun, Y; Wan, Z; Wu, X; Yao, W; Zhang, W; Zhao, H, 2015) |
| "The study showed that in patients with hypertension and metabolic syndrome, both losartan and eprosartan have a neutral effect on fasting and postfructose load serum uric acid concentration and its urinary excretion." | 5.41 | Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome. ( Majer, J; Masajtis-Zagajewska, A; Nowicki, M, 2021) |
| "The aim of the present study is to present a historical and unified perspective on the association of serum uric acid (SUA) in the cause of cardiovascular diseases (CVDs)." | 5.41 | Association of hyperuricemia with cardiovascular diseases: current evidence. ( Chrysant, SG, 2023) |
| "A direct relationship between serum uric acid levels and hypertension, cardiovascular, renal and metabolic diseases has been reported in many basic and epidemiological studies." | 5.41 | Update in uric acid, hypertension, and cardiovascular diseases. ( Ae, R; Andres-Hernando, A; Borghi, C; Hisatome, I; Kanbay, M; Kodama, T; Kuwabara, M; Lanaspa, MA, 2023) |
| "Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) is well controlled." | 5.41 | Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia. ( Abe, Y; Fukumoto, Y; Hisatome, I; Hongou, M; Hoshide, S; Kario, K; Kasai, T; Kiuchi, M; Kiyosue, A; Kuga, H; Kuramochi, J; Miyazaki, S; Nishizawa, M; Ohtani, H; Tomita, F; Yasu, T, 2021) |
| "We conducted a post hoc analysis of results from a prospective trial in which the proteinuria-reducing effects of losartan and enalapril were compared." | 5.41 | Effects of losartan and enalapril on serum uric acid and GFR in children with proteinuria. ( Bryant, CE; Hogg, RJ; Rajai, A; Webb, NJA, 2021) |
| "Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee." | 5.40 | Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: a hospital based cross sectional study. ( Jha, B; Kumar, A; Poudel, B; Raut, KB; Yadav, BK, 2014) |
| "Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults." | 5.40 | Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. ( Bjornstad, P; Chonchol, MB; Jalal, D; Johnson, RJ; Maahs, DM; McFann, K; Paul Wadwa, R; Rewers, M; Rivard, CJ; Sirota, JC; Snell-Bergeon, JK, 2014) |
| "Mild hyperuricemia is a strong, independent marker of MS and high cardio-renal risk profile in hypertensive patients under specialist care." | 5.40 | Serum uric acid and its relationship with metabolic syndrome and cardiovascular risk profile in patients with hypertension: insights from the I-DEMAND study. ( Agabiti Rosei, E; Ambrosioni, E; Costa, FV; Deferrari, G; Garneri, D; Gonnella, A; Leoncini, G; Leonetti, G; Muiesan, ML; Pessina, AC; Pontremoli, R; Trimarco, B; Viazzi, F; Volpe, M, 2014) |
| "In conclusion, hyperhomocysteinemia is associated with carotid RI, a surrogate marker of cerebral vascular resistance, especially in elderly men." | 5.40 | Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males. ( Enomoto, D; Higaki, J; Irita, J; Kudo, K; Kukida, M; Miyoshi, K; Nagao, T; Okura, T; Pei, Z; Tanino, A, 2014) |
| "Uric acid (UA) is a marker of endothelial dysfunction." | 5.40 | The relationship between uric acid and erectile dysfunction in hypertensive subjects. ( Akilli, H; Alibasic, H; Aribas, A; Avci, A; Demir, K; Kanbay, M; Katlandur, H; Kaya, Z; Kayrak, M; Keser, A; Solak, Y; Turan, Y; Ulucan, S, 2014) |
| "Hypertension is a key risk factor for cardiovascular disease, and new treatments are needed." | 5.40 | Allopurinol initiation and change in blood pressure in older adults with hypertension. ( Beattie, CJ; Dawson, J; Dominiczak, AF; Fulton, RL; Higgins, P; McCallum, L; Padmanabhan, S; Touyz, RM; Walters, MR, 2014) |
| " There were dose-response relationships between arsenic exposure and PUA levels." | 5.40 | Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh. ( Aktar, S; Alam, S; Ali, N; Arefin, A; Aziz, A; Himeno, S; Hossain, K; Hossain, MI; Hossain, S; Huda, N; Islam, K; Karim, MR; Mamun, AA; Miyataka, H; Mohanto, NC; Rahman, M; Salam, KA; Saud, ZA, 2014) |
| "Uric acid levels were similar in both groups during the first half of gestation." | 5.40 | [Serum uric acid levels and risk of developing preeclampsia]. ( Balconi, SM; Corominas, AI; Damiano, AE; Maskin, B; Palermo, M, 2014) |
| "Hyperuricemia was defined as SUA ≥70 mg/L in men and ≥60 mg/L in women." | 5.38 | Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome. ( Gonçalves, JP; Lopes, C; Oliveira, A; Santos, AC; Severo, M, 2012) |
| "Hyperuricemia is an independent predictor for early atherosclerosis in hypertensive subjects with normal renal function." | 5.38 | Uric acid is an important predictor for hypertensive early atherosclerosis. ( Bahadir, E; Citil, R; Deger, SM; Durmaz, AO; Mutluay, R; Sindel, S, 2012) |
| "Uric acid (UA) has been frequently reported to be associated with MetS in the general population." | 5.38 | The relationship between serum uric acid concentration and metabolic syndrome in patients with schizophrenia or schizoaffective disorder. ( Chen, CH; Chen, PY; Chiu, CC; Huang, MC; Lu, ML; Tsai, CJ, 2012) |
| "Uric acid (UA) is a cardiovascular risk marker associated with oxidative stress and inflammation." | 5.37 | Uric acid levels and atrial fibrillation in hypertensive patients. ( Korantzopoulos, P; Li, G; Liu, T; Wang, S; Zhang, X, 2011) |
| "Uric acid was significantly associated with increased likelihood for diastolic HTN (OR = 2." | 5.35 | Serum uric acid and ambulatory blood pressure in children with primary hypertension. ( Alpert, BS; Jones, DP; Li, R; Richey, PA, 2008) |
| "Moreover, hyperuricemia is significantly correlated with hypertriglyceridemia, hypertension, and visceral obesity." | 5.35 | Serum uric acid levels and risk of metabolic syndrome in healthy adults. ( Bandarian, F; Ebrahimpour, P; Fakhrzadeh, H; Heshmat, R; Larijani, B, 2008) |
| "To investigate the association of baseline serum uric acid (UA) with new-onset diabetes, and to explore the possible effect modifiers in Chinese adults with hypertension." | 5.34 | Positive association of serum uric acid with new-onset diabetes in Chinese women with hypertension in a retrospective analysis of the China Stroke Primary Prevention Trial. ( Hu, W; Liang, M; Liu, C; Liu, L; Liu, M; Nie, J; Qin, X; Song, Y; Wang, B; Wang, X; Xu, X; Zhang, Y; Zhang, Z; Zhou, C, 2020) |
| "825), high-dose CCBs combined with ARBs controlled hypertension without elevation of serum uric acid." | 5.34 | Assessment of suitable antihypertensive therapies: Combination with high-dose amlodipine/irbesartan vs triple combination with amlodipine/irbesartan/indapamide (ASAHI-AI study). ( Hasebe, N; Koyama, S; Maruyama, J; Morimoto, H; Nakagawa, N; Nakamura, Y; Ogawa, Y; Ohta, T; Saijo, Y; Sato, N; Takeuchi, T; Uekita, K, 2020) |
| "Moreover, according to the presence of left ventricular hypertrophy (LVH) the participants were subdivided into two additional groups: [LVH (+), n=305 and LVH (-), n=537]." | 5.33 | The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage. ( Antoniadis, D; Chatzis, D; Dimitriadis, K; Kallikazaros, I; Lalos, S; Stefanadis, C; Toutouzas, P; Tsioufis, C; Vezali, E; Zervoudaki, A, 2005) |
| "To assess the efficacy and safety of febuxostat extended release (XR) and immediate release (IR) in patients with gout and normal or impaired renal function." | 5.30 | Efficacy and Safety of Febuxostat Extended and Immediate Release in Patients With Gout and Renal Impairment: A Phase III Placebo-Controlled Study. ( Becker, MA; Castillo, M; Gunawardhana, L; Hunt, B; Kisfalvi, K; Saag, KG; Whelton, A, 2019) |
| "The European Lacidipine Study on Atherosclerosis (ELSA) was a randomized, double-blind, multicenter trial comparing the effects of a 4-year treatment with either lacidipine or atenolol on progression of carotid atherosclerosis in patients with moderate hypertension." | 5.30 | Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis. ( Bombelli, M; Cuspidi, C; Facchetti, R; Grassi, G; Macchiarulo, M; Maggiolini, D; Mancia, G; Parati, G, 2019) |
| "Uric acid (UA) is a promising protective treatment in ischaemic stroke, but the precise molecular targets underlying its in vivo beneficial actions remain unclear." | 5.30 | Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension. ( Amaro, S; Chamorro, Á; D'Ocon, P; Dantas, AP; Jiménez-Altayó, F; Masip, N; Planas, AM; Puertas-Umbert, L; Solé, M; Unzeta, M; Vila, E, 2019) |
| "From these data it emerges that hyperaldosteronism, as observed in these patients with CRI, is a relatively reliable marker of the extent of CRI and may occur independently of the activation of the RAA system, given that other factors, such as orthostatic stimulation, alterations in the acid-base equilibrium, and the degree of aldosterone hepatic and urinary clearance, contribute to its pathogenesis." | 5.29 | [Role of aldosterone in essential arterial hypertension complicated by chronic renal insufficiency]. ( Buracchi, P; Carletti, F; Gennari, C; Lucani, B; Martinelli, M; Nami, R; Panza, F; Pavese, G; Saia, F, 1993) |
| "Hydrochlorothiazide was discontinued if the diastolic blood pressure remained less than or equal to 94 mm Hg after a 6-month period on the lower dose of hydrochlorothiazide." | 5.28 | Effects of reduction in dose and discontinuation of hydrochlorothiazide in patients with controlled essential hypertension. ( Kochar, MS; Landry, KM; Ristow, SM, 1990) |
| "To examine whether partial replacement of a diet typical of the average American diet with Dietary Approaches to Stop Hypertension (DASH)-related foods in the home environment lowers the serum uric acid (UA) level in individuals with hypertension." | 5.27 | Effects of a Dietary Approach to Stop Hypertension (DASH) Diet Intervention on Serum Uric Acid in African Americans With Hypertension. ( Cooper, LA; Juraschek, SP; Miller, ER; Tang, O; White, K; Yeh, HC, 2018) |
| " The mean resting blood pressures were 168/108 mmHg, 151/98 mmHg and 150/96 mmHg at pre-trial, after the twice-daily dosage period and after the once-daily dosage period, respectively." | 5.26 | A fixed combination of metoprolol and hydrochlorothiazide for hypertension: a multi-centre study. ( Goodfellow, RM, 1979) |
| "The Dietary Approaches to Stop Hypertension (DASH) diet lowers serum uric acid (SUA) levels compared to the typical American (control) diet." | 5.24 | DASH diet and change in serum uric acid over time. ( Appel, LJ; Choi, HK; Gelber, AC; Juraschek, SP; Miller, ER; Tang, O, 2017) |
| " This study aimed to explore the correlation between serum uric acid (SUA) concentration and hypertensive retinopathy in hypertensive adults." | 5.24 | Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults. ( Chen, X; Gu, X; Hou, F; Huo, Y; Li, J; Liao, R; Meng, Y; Peng, Y; Qin, X; Shang, K; She, H; Tang, G; Wang, B; Xu, X; Yang, L; Yang, W; Zhang, J; Zhang, Y; Zhao, L, 2017) |
| "There is little evidence guiding selection of nondiuretic, antihypertensive agents with a goal of lowering uric acid (SUA) and minimizing gout risk." | 5.24 | Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension. ( Appel, LJ; Juraschek, SP; Miller, ER, 2017) |
| "Hyperuricemia is associated with hypertension, with elevated serum uric acid levels postulated to have a causal role in the development of hypertension." | 5.24 | Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study. ( Feig, DI; Gunawardhana, L; Hunt, B; McLean, L; Palmer, RN; Punzi, HA; Whelton, A, 2017) |
| "Uric acid (UA) has been associated with hypertension, renal disease and cardiovascular disease." | 5.24 | Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia. ( Arima, H; Hayashi, S; Ishizuka, A; Iwashima, Y; Kawano, Y; Kishida, M; Nakamura, S; Ohta, Y; Yoshihara, F, 2017) |
| " In the setting of hypertensive disorders of pregnancy, oral antihypertensive medications should be initiated when systolic blood pressure is greater than 160 mm Hg or when diastolic blood pressure is greater than 110 mm Hg, with the most ideal agents being labetalol or nifedipine." | 5.22 | Hypertensive Disorders of Pregnancy: Common Clinical Conundrums. ( Dotters-Katz, S; Kuller, JA; Lim, SL; Ohamadike, O; Siegel, A; Zemtsov, G, 2022) |
| "Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension." | 5.22 | Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk. ( Agnoletti, D; Borghi, C; Cicero, AFG; Lurbe, E; Virdis, A, 2022) |
| "Studies examining the association between levels of serum uric acid (SUA) and risk of prehypertension still remained controversial conclusions." | 5.22 | Serum uric acid and risk of prehypertension: a dose-response meta-analysis of 17 observational studies of approximately 79 thousand participants. ( Han, M; Hong, F; Li, Q; Liu, L; Qie, R; Zhan, S; Zhang, C; Zhang, J; Zhang, L; Zhang, X, 2022) |
| "A single-pill fixed-dose combination therapy with irbesartan 100 mg/day and amlodipine 5 mg/day was superior to the combination of valsartan 80 mg/day and amlodipine 5 mg/day with respect to significant decreases in BP, serum UA and TG in patients with hypertension." | 5.22 | Efficacy and safety of two single-pill fixed-dose combinations of angiotensin II receptor blockers/calcium channel blockers in hypertensive patients (EXAMINER study). ( Adachi, S; Fujisawa, K; Inoue, T; Kusumoto, T; Miura, S; Motozato, K; Saku, K; Shiga, Y, 2016) |
| " Additional endpoints included other hemodynamic measures, serum uric acid, fasting plasma glucose, body weight, blood lipids and heart rate." | 5.22 | Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade. ( Alessi, F; Iqbal, N; Mansfield, TA; Parikh, S; Ptaszynska, A; Weber, MA, 2016) |
| "A relationship of blood uric acid (UA) with hypertension and cardiovascular risk is under debate thus salt intake is hypothesized to contribute to such associations." | 5.22 | Influence of Salt Intake on Association of Blood Uric Acid with Hypertension and Related Cardiovascular Risk. ( Asaiti, K; Han, W; Hou, L; Jiang, J; Liang, S; Pang, H; Qiu, C; Tang, Y; Wang, W; Wang, Y; Wang, Z; Xue, F; Zhang, B; Zhang, M, 2016) |
| " This prospective randomized open-label study compared the efficacy and safety of a fixed-dose tablet of losartan (LST)-hydrochlorothiazide (HCTZ) (n = 99) and LST-amlodipine (AML) (n = 77) in Japanese patients whose hypertension was uncontrolled by ARB monotherapy." | 5.19 | Angiotensin receptor blocker (ARB)-diuretic versus ARB-calcium channel blocker combination therapy for hypertension uncontrolled by ARB monotherapy. ( Hanaoka, K; Hasegawa, T; Kaizu, K; Kamata, K; Kimura, K; Kobayashi, S; Morita, S; Ohtake, T; Oshikawa, J; Sato, T; Taguri, M; Toya, Y; Umemura, S; Yasuda, G, 2014) |
| "Forty-four adolescents, aged 12-19 years, newly diagnosed as essential hypertension (secondary hypertension was excluded) and previously untreated were randomized (open label trial) to receive either enalapril or enalapril plus allopurinol in combination." | 5.19 | Allopurinol enhances the blood pressure lowering effect of enalapril in children with hyperuricemic essential hypertension. ( Assadi, F, 2014) |
| " In this study, we assessed the additive effects of hydrochlorothiazide (HCTZ) on reducing proteinuria in CKD patients under treatment with losartan (LS)." | 5.19 | Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension. ( Fujisaki, K; Higashi, H; Hirakata, H; Kanai, H; Katafuchi, R; Kitazono, T; Nakano, T; Nakayama, M; Taniguchi, M; Tsuruya, K, 2014) |
| "Previous epidemiologic studies have demonstrated an association between uric acid and hypertension." | 5.17 | Does decreasing serum uric acid level prevent hypertension? - a nested RCT in cohort study: rationale, methods, and baseline characteristics of study cohort. ( Huang, G; Jiao, H; Lu, W; Song, K; Wang, G; Wang, Y; Zhang, Q, 2013) |
| "We examined blood pressure reduction and metabolic alterations after amlodipine/benazepril and valsartan/hydrochlorothiazide treatment in patients with type 2 diabetes mellitus and hypertension and microalbuminuria." | 5.16 | Comparison of the efficacy and safety profiles of two fixed-dose combinations of antihypertensive agents, amlodipine/benazepril versus valsartan/hydrochlorothiazide, in patients with type 2 diabetes mellitus and hypertension: a 16-week, multicenter, rando ( Chen, JF; Hung, YJ; Lee, IT; Lee, WJ; Sheu, WH; Wang, CY, 2012) |
| "The purpose of the study was to investigate the effect of interval and continuous training program on blood pressure and serum uric acid (SUA) levels in subjects with hypertension." | 5.15 | Comparative effect of interval and continuous training programs on serum uric acid in management of hypertension: a randomized controlled trial. ( Lamina, S, 2011) |
| "The aim of the study was to evaluate the influence of allopurinol on blood pressure and aortic compliance in patients with arterial hypertension depending on hypotensive therapy with angiotensin-converting enzyme inhibitor (ACE-I) or thiazide diuretic, hypotensive drugs with distinct effects on serum uric acid levels and conversely, a positive influence on pulse wave velocity (PWV) in the aorta." | 5.15 | Effect of allopurinol on blood pressure and aortic compliance in hypertensive patients. ( Kostka-Jeziorny, K; Tykarski, A; Uruski, P, 2011) |
| "Elevated serum uric acid is considered to be positively associated with cardiovascular event risk factor in hypertension." | 5.15 | Uricaemia as a cardiovascular events risk factor in hypertension: the role of interval training programme in its downregulation. ( Lamina, S; Okoye, CG, 2011) |
| "The precise relationship of Hyperuricemia found in hypertensive patients is still obscure; this study is a urinary uric acid lowering intervention with Losartan in hypertensive patients induced by Thiazide diuretics." | 5.15 | To study the efficacy of Losartan on urinary uric acid excretion in Thiazide induced hyperuricemic and hypertensive patients. ( Islam, F; Jamali, SN; Khan, M; Khan, RA; Laghari, J, 2011) |
| "It has been reported that elevated levels of serum uric acid are related to hypertension and cardiovascular disease." | 5.15 | Association of serum uric acid with blood pressure in Japanese men. Cross-sectional study in work-site group. ( Fukuhara, M; Goto, K; Ichishima, K; Kansui, Y; Matsumura, K; Ohta, Y; Ohtsubo, T; Sakata, S, 2011) |
| "Patients with arterial hypertension of the first-second degree with persistent elevated levels of uric acid in blood serum had significantly higher levels of ED markers: albuminuria, plasmic endothelin concentration." | 5.15 | [Clinical implication of endothelial dysfunction in patients with essential arterial hypertension and urate dysbolism with renal damage]. ( , 2011) |
| "Excessive fructose intake causes metabolic syndrome in animals and can be partially prevented by lowering the uric acid level." | 5.14 | Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. ( Johnson, RJ; Lillo, JL; Nakagawa, T; Perez-Pozo, SE; Sánchez-Lozada, LG; Schold, J, 2010) |
| " Serum insulin, glucose, C-reactive protein (CRP), lipids, uric acid, YKL-40 and blood pressure were measured and insulin sensitivity was calculated (HOMA) at the beginning and end of each study phase." | 5.14 | Effect of moxonidine and amlodipine on serum YKL-40, plasma lipids and insulin sensitivity in insulin-resistant hypertensive patients-a randomized, crossover trial. ( Majer, J; Masajtis-Zagajewska, A; Nowicki, M, 2010) |
| "The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) > or = 8." | 5.14 | The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. ( Becker, MA; Espinoza, LR; Lademacher, C; Lloyd, E; MacDonald, P; Schumacher, HR; Wells, AF, 2010) |
| "It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH)." | 5.14 | Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study. ( Dahlöf, B; Devereux, RB; Høieggen, A; Ibsen, H; Kjeldsen, SE; Larstorp, AC; Lindholm, L; Okin, PM; Olsen, MH; Wachtell, K; Wiik, BP, 2010) |
| "To determine whether lowering uric acid lowers blood pressure (BP) in hyperuricemic adolescents with newly diagnosed hypertension." | 5.13 | Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. ( Feig, DI; Johnson, RJ; Soletsky, B, 2008) |
| "To survey the prevalence of hyperuricacidemia and serum uric acid (SUA) changes and electrolyte changes after 6 weeks antihypertensive treatment with thiazide diuretics, losartan or losartan+hydrochlorothiazide (Hyzaar) in patients with essential hypertension (EH)." | 5.13 | [Serum uric acid prevalence and changes post various antihypertensive agents in patients with essential hypertension]. ( Chen, H; Gui, W; Lu, LH; Wu, XY; Yang, LQ; Yu, L, 2008) |
| "This study used ambulatory blood pressure monitoring (ABPM) to compare the blood pressure (BP)-lowering effects of valsartan and enalapril over the 24 hours after missing 1 dose in previously untreated patients with mild to moderate essential hypertension." | 5.13 | Ambulatory blood pressure-lowering effects of valsartan and enalapril after a missed dose in previously untreated patients with hypertension: a prospective, randomized, open-label, blinded end-point trial. ( Ayala, DE; Calvo, C; Hermida, RC; Khder, Y, 2008) |
| "To evaluate the clinical efficacy and safety of a new angiotensin II type 1 receptor blocker, pratosartan, in patients with mild-to-moderate essential hypertension, a multicenter, open-label study was conducted." | 5.13 | Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients. ( Matsuoka, H; Ogihara, T; Rakugi, H; Saruta, T; Shimamoto, K, 2008) |
| "Our aim in this study was to investigate the changes of serum high-sensitive C-reactive protein (hs-CRP) and uric acid (UA), and evaluate the synergistic effect of amlodipine and atorvastatin on blood pressure and left ventricular remodeling in hypertensive patients with primary hypercholesterolemia." | 5.13 | Synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling, and C-reactive protein in hypertensive patients with primary hypercholesterolemia. ( Chen, YD; Ge, CJ; Hu, SJ; Ji, Y; Lu, SZ; Wu, XF, 2008) |
| " Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases." | 5.12 | Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis. ( Kimura, Y; Kono, H; Tsukui, D, 2021) |
| "Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but also may play roles in developing cardiovascular diseases such as hypertension, atrial fibrillation, chronic kidney disease, heart failure, coronary artery disease, and cardiovascular death." | 5.12 | Uric acid and cardiovascular disease: A clinical review. ( Kobayashi, Y; Node, K; Saito, Y; Tanaka, A, 2021) |
| "Studies on the association of uric acid with mortality and cardiovascular outcomes in patients with hypertension have produced contradictory results." | 5.12 | Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis. ( Jin, Z; Yang, Y; Zhang, X; Zhao, Q, 2021) |
| "Losartan is an optimum choice of medication for patients with mild-to-moderate hypertension complicating hyperuricemia." | 5.12 | [The effects of angiotensin II receptor blockers in hypertensive patients complicating hyperuricaemia]. ( Chen, GL; Dang, AM; Liu, GZ; Zhang, YH, 2006) |
| "It is still undefined whether serum uric acid (SUA) is an independent risk factor for target organ damage (TOD) and cardiovascular events in human hypertension." | 5.12 | Lack of association between serum uric acid and organ damage in a never-treated essential hypertensive population at low prevalence of hyperuricemia. ( Cuspidi, C; Esposito, A; Mancia, G; Meani, S; Sala, C; Valerio, C; Zanchetti, A, 2007) |
| "In a randomized, prospective (4 weeks), double blind, parallel study we have compared the influence of losartan (50 mg/day) versus eprosartan (600 mg/day) on uric acid metabolism in 58 patients with mild to moderate essential hypertension." | 5.10 | AT1 blockers and uric acid metabolism: are there relevant differences? ( Puig, JG; Ruilope, LM; Torres, R, 2002) |
| "In a Swedish-Finnish long-term multicenter study 256 patients with mild to moderate hypertension were randomized to treatment with diltiazem retard (D) (n = 127) or atenolol (A) (n = 129)." | 5.09 | Long-term effects of diltiazem and atenolol on blood glucose, serum lipids, and serum urate in hypertensive patients. Swedish-Finnish Study Group. ( Berglund, E; Dahlöf, C; Engqvist, L; Lagerstedt, C; Lehtonen, A; Nilsson-Ehle, P; Thulin, T, 1999) |
| " This study was designed to compare the effects of losartan and eprosartan on uric acid metabolism in patients with mild to moderate essential hypertension." | 5.09 | Effect of eprosartan and losartan on uric acid metabolism in patients with essential hypertension. ( Buño, A; Dal-Ré, R; Mateos, F; Ortega, R; Puig, JG; Rodriguez, F, 1999) |
| "The purpose of this study was to assess the safety and antihypertensive dose-response effects of irbesartan and hydrochlorothiazide (HCTZ) in patients with mild-to-moderate hypertension." | 5.09 | Matrix study of irbesartan with hydrochlorothiazide in mild-to-moderate hypertension. ( Guthrie, R; Kassler-Taub, K; Kochar, M; Reeves, RA; Triscari, J, 1999) |
| "To examine the relationship between raised serum uric acid and subsequent cardiovascular events (mortality, myocardial infarction, stroke)." | 5.09 | Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans? ( Longo-Mbenza, B; Luila, EL; Mbete, P; Vita, EK, 1999) |
| "Losartan is an angiotensin II receptor blocker indicated for treatment of hypertension." | 5.09 | Comparison of antihypertensive and metabolic effects of losartan and losartan in combination with hydrochlorothiazide--a randomized controlled trial. ( Fitzgerald, D; Kelly, L; Nallen, R; O'Brien, E; Owens, P; Ryan, D, 2000) |
| " We sought to assess the antihypertensive and metabolic effects of the new dihydropyridine calcium antagonist manidipine (M) in patients with diabetes mellitus and essential hypertension as compared with the ACE inhibitor enalapril (E)." | 5.09 | Antihypertensive efficacy of manidipine and enalapril in hypertensive diabetic patients. ( Agabiti-Rosei, E; Casati, R; Fogari, R; Leonetti, G; Mancia, G; Montemurro, G; Nami, R; Omboni, S; Pessina, AC; Pirrelli, A; Zanchetti, A, 2000) |
| "In this case-control study in uncomplicated subjects with essential hypertension, losartan and enalapril, alone or combined with a diuretic, effectively and equally lowered office and ambulatory blood pressure and induced a significant reduction in left ventricular mass during long-term treatment." | 5.09 | Long-term effects of losartan and enalapril, alone or with a diuretic, on ambulatory blood pressure and cardiac performance in hypertension: a case-control study. ( Benemio, G; Bruni, B; Porcellati, C; Reboldi, GP; Sacchi, N; Schillaci, G; Verdecchia, P, 2000) |
| "Serum uric acid independently predicts cardiovascular events in older persons with isolated systolic hypertension." | 5.09 | Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). ( Applegate, WB; Di Bari, M; Franse, LV; Pahor, M; Shorr, RI; Somes, GW; Wan, JY, 2000) |
| "These favourable effects of comicronised fenofibrate both on lipid and non lipid parameters, including insulin sensitivity, may confer to this product a particular interest in the treatment of patients with polymetabolic syndrome X." | 5.09 | Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X. ( Blane, G; Idzior-Walus, B; Kawalec, E; Rostworowski, W; Sieradzki, J; Wójcik, J; Zarnecki, A; Zdzienicka, A, 2000) |
| "We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged >/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure >/=160/<95 mm Hg)." | 5.09 | Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension. ( Birkenhäger, WH; Fagard, RH; Gong, L; Liu, L; Staessen, JA; Wang, JG, 2001) |
| "Twenty-six patients with stable renal function and hypertension, 16 men and 10 women, median age 47 years (range, 25-63 years), were studied in an open randomized crossover trial, comparing a 2-week control period with a 2-week period of once-daily administration of 50 mg of losartan." | 5.09 | Uricosuric effect of losartan in patients with renal transplants. ( Kamper, AL; Nielsen, AH, 2001) |
| "Patients > or = 21 years of age with mild to moderate hypertension, defined as a trough sitting diastolic blood pressure (SiDBP) between 95 and 115 mm Hg, were randomized to receive once-daily losartan (50 mg) or valsartan (80 mg) for 12 weeks." | 5.09 | Losartan versus valsartan in the treatment of patients with mild to moderate essential hypertension: data from a multicenter, randomized, double-blind, 12-week trial. ( Calhoun, DA; DeLucca, PT; Elliott, WJ; Gazdick, LP; Kerns, DE; Zeldin, RK, 2001) |
| "This study was conducted in 19 patients with mild or moderate essential hypertension randomised open trial to evaluate the influence of potassium losartan dosed 50 mg per day on blood pressure, metabolic processes and left ventricular heart function." | 5.09 | [Estimation of blood pressure, selected biochemical parameters and indices of left ventricular heart function in patients with mild or moderate essential hypertension treated with potassium losartan]. ( Badowski, R; Cieślik, P; Haczkiewicz, P; Hefczyc, J; Hrycek, A; Scieszka, J, 2001) |
| "The pharmacokinetic and pharmacodynamic alterations of multiple doses of losartan, an angiotensin II receptor antagonist, were examined in nine patients with essential hypertension." | 5.08 | Clinical pharmacology of multiple-dose losartan, an angiotensin II receptor antagonist, in patients with essential hypertension. ( Ebihara, A; Fujimura, A; Harada, K; Sasaki, M; Sunaga, K, 1996) |
| "We examined the renal hemodynamic modifications induced by a selective angiotensin II (AII) AT1 receptor antagonist, losartan, in 10 patients with essential hypertension." | 5.08 | Effects of losartan on renal function in patients with essential hypertension. ( Berra, N; Fauvel, JP; Laville, M; Madonna, O; Pozet, N; Velon, S; Zech, P, 1996) |
| "Antihypertensive therapy with low-dose chlorthalidone (supplemented if necessary) for isolated systolic hypertension lowers blood pressure and its cardiovascular disease complications and has relatively mild effects on other cardiovascular disease risk factor levels." | 5.08 | Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: The Systolic Hypertension in the Elderly Program. SHEP Cooperative Re ( Applegate, WB; Black, HR; Cohen, J; Curb, JD; Davis, BR; Frost, P; Gonzalez, N; Guthrie, GP; Oberman, A; Pressel, SL; Probstfield, JL; Rutan, G; Savage, PJ; Schron, EB; Smith, W; Stamler, J, 1998) |
| " Therefore, the effects of single and repeated doses of eprosartan on uric acid excretion were evaluated in 57 male patients with mild-to-moderate essential hypertension in a double-blind, randomized, placebo-controlled, repeated dose, dose-rising, two-period, period-balanced, crossover study conducted in two parts." | 5.08 | The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension. ( Boike, SC; Ilson, BE; Jorkasky, DK; Martin, DE, 1998) |
| "The present study was designed to compare the safety and efficacy of the new angiotensin-converting enzyme inhibitor moexipril with that of hydrochlorothiazide (HCTZ) in postmenopausal women with mild-to-moderate hypertension." | 5.08 | Antihypertensive treatment in postmenopausal women: results from a prospective, randomized, double-blind, controlled study comparing an ACE inhibitor (moexipril) with a diuretic (hydrochlorothiazide). ( Koch, B; Oparil, S; Stimpel, M, 1998) |
| "The antihypertensive efficacy of single-drug therapy with nifedipine (N), prazosin (P), or acebutolol (A) and the influence of these agents on coronary risk factors including hypoglycemia, hyperuricemia, and hyperlipidemia, were studied in adolescents with hypertension." | 5.07 | [Evaluation of the efficacy and tolerance of three antihypertensive agents used as single-drug therapy, nifedipine, prazosin and acebutolol in severe, idiopathic hypertension in adolescents]. ( Cichocka, E; Januszewicz, P; Wyszynska, T, 1993) |
| "Twenty-three patients with essential hypertension were treated consecutively with prazosin or dihydrochlorothiazide or the combination of the two, each treatment period lasting for three months." | 5.06 | Prazosin improves atherogenic index and inhibits the deleterious effect of dihydrochlorothiazide in patients with essential hypertension. ( Balás-Eltes, A; Farsang, C; Fehér, J; Péter, M, 1987) |
| "The effects of chronic administration of traxanox sodium (traxanox) on blood pressure and serum uric acid level were investigated in 15 patients who had mild to moderate hypertension." | 5.06 | Effects of traxanox sodium on blood pressure and serum uric acid in hypertensive patients: a preliminary study. ( Ebihara, A; Fujimura, A; Hino, N; Koike, Y, 1989) |
| "To evaluate the potential therapeutic value of calcium antagonists in hypertension associated with impaired renal function, blood pressure (BP), certain regulatory factors, and metabolic correlates of cardiovascular risk have been assessed in 15 patients with mild to marked chronic renal failure before and after 6 weeks of therapy with nitrendipine." | 5.06 | Antihypertensive and hypouricaemic effects of nitrendipine in chronic renal failure. ( Gnädinger, MP; Jahn, H; Riesen, W; Schohn, D; Weidmann, P, 1989) |
| "The acute and chronic effects of pinacidil on blood pressure (BP) and renal function were investigated in 10 patients with moderate arterial hypertension insufficiently controlled by chronic beta-blockade." | 5.06 | Renal effects of pinacidil in hypertensive patients on chronic beta-blocker therapy. ( Christensen, CK; Krusell, LR; Lederballe Pedersen, O, 1986) |
| "The blood pressure of patients with hypertension who were aged between 60 and 75 years responded equally well to treatment with metoprolol (100 mg a day) or hydrochlorothiazide (25 mg a day) in a double-blind study which employed random allocation to two parallel groups." | 5.06 | Metoprolol or hydrochlorothiazide in patients with hypertension aged 60-75 years. With special reference to assessment of compliance. Hunter Hypertension Research Group. ( , 1986) |
| "Twenty-four black men with mild to moderate essential hypertension were enrolled in an open-label trial comparing the efficacy of two doses of Capozide (captopril and hydrochlorothiazide)." | 5.06 | Treating black hypertensives with capozide. ( Cobbol, C; Katz, LA, 1988) |
| "The short-term effects of manipulating dietary salt intake on plasma levels of cholesterol, lipoproteins and uric acid were studied in two groups of patient with essential hypertension." | 5.06 | Changes in plasma lipids and uric acid with sodium loading and sodium depletion in patients with essential hypertension. ( Hasegawa, T; Hashizume, K; Kumahara, Y; Masugi, F; Ogihara, T; Sakaguchi, K, 1988) |
| "5 mg indapamide was compared in patients with essential hypertension, known as responders to diuretic therapy." | 5.06 | Comparative study on the antihypertensive efficacy of torasemide and indapamide in patients with essential hypertension. ( Achhammer, I; Glocke, M; Metz, P; Spannbrucker, N, 1988) |
| "This randomised, double-blind, crossover study investigated the haemodynamic effects of a beta-blocker (atenolol 50mg) and a calcium antagonist (sustained release nifedipine 20mg) given either separately or in combination in 3 groups of patients with mild to moderate essential hypertension." | 5.06 | Efficacy and tolerability of atenolol, nifedipine and their combination in the management of hypertension. ( Heath, ID; Larkin, H; Stanley, NN; Thirkettle, JL; Varma, MP, 1988) |
| "Nifedipine has been used in hypertension, mainly as a third-line drug for rapid blood pressure reduction, for over 10 years." | 5.06 | Is nifedipine a suitable first-line treatment for essential hypertension in general practice? ( Adams-Strump, BJ; Gaw, N; Langan, JJ; Murray, TS; Sullivan, FM, 1987) |
| "One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12." | 5.06 | Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986) |
| "The pharmacodynamic effects of torasemide, a new potent loop diuretic, were compared with those of furosemide in a double blind controlled study in 18 hypertensive patients with oedema of various origins." | 5.06 | Torasemide, a new potent diuretic. Double-blind comparison with furosemide. ( Broekhuysen, J; Deger, F; Douchamps, J; Ducarne, H; Herchuelz, A, 1986) |
| "The acute effects of buccal nifedipine 20 mg on blood pressure, renal haemodynamics and electrolyte excretion were compared in 16 untreated patients (HT) with uncomplicated arterial hypertension (WHO I-II), 11 normotensives (NT) and 6 normotensives given a placebo." | 5.06 | Acute natriuretic effect of nifedipine in hypertensive patients and normotensive controls--a proximal tubular effect? ( Christensen, CK; Krusell, LR; Lederballe Pedersen, O, 1987) |
| "Men and women with isolated systolic hypertension who were at least 60 years of age were treated for 1 year with chlorthalidone (25-50 mg daily) or matching placebo as the step I drug." | 5.06 | Use of diuretics in treatment of hypertension in the elderly. ( Feigal, DW; Furberg, CD; Greenlick, M; Kuller, L; Perry, HM; Schnaper, HW; Schoenberger, JA; Smith, WM, 1986) |
| " In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age." | 5.05 | Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age. ( Esposito, P; Garibotto, G; Leoncini, G; Pontremoli, R; Russo, E; Viazzi, F, 2020) |
| "High serum uric acid seems to be associated with pre-eclampsia." | 5.05 | Predictive value of serum uric acid levels for adverse maternal and perinatal outcomes in pregnant women with high blood pressure. A systematic review and meta-analysis. ( Pecoraro, V; Trenti, T, 2020) |
| "Fifty-three patients with mild to moderate essential hypertension were treated with enalapril (10-40 mg q." | 5.05 | Long-term antihypertensive, metabolic and cellular effects of enalapril. ( Ambrosioni, E; Magnani, B; Malini, PL; Strocchi, E, 1984) |
| "A beta-blocker (pindolol) and a diuretic (clopamide) were given in different dosages, singly and in two different combinations, to 71 patients with mild to moderate essential hypertension." | 5.05 | New design for clinical trial of antihypertensive drugs applied to pindolol, clopamide, and combinations thereof. ( Anagreus, N; Asplund, J; Aström, B; Bergström, R; Kullman, S; Leppert, J; Lessem, J; Nyberg, G; Overmo, J, 1982) |
| "The effects of propranolol and prazosin on plasma lipoproteins in patients with essential hypertension were evaluated according to a crossover protocol of two 8-week periods with a washout of 4 to 6 weeks." | 5.05 | Plasma lipid and lipoprotein changes in hypertensive patients treated with propranolol and prazosin. ( Franceschini, G; Gemma, G; Mantero, O; Montanari, G; Paralovo, A; Sirtori, CR; Suppa, G, 1982) |
| "41 patients (35 males and 6 females) with moderate hypertension were treated with a combination of methyldopa/hydrochlorothiazide/amiloride (M/HCT/A)." | 5.05 | [A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension]. ( Bolzano, K; Krempler, F; Sandhofer, F, 1984) |
| "The results of an investigation to assess the clinical responses of patients with mild to moderate hypertension to a new combination formulation containing 75 mg triamterene and 50 mg hydrochlorothiazide are reported." | 5.05 | Clinical experience with a new combination formulation of triamterene and hydrochlorothiazide (Maxzide) in patients with mild to moderate hypertension. ( Blume, CD; Clark, T; Williams, RL, 1984) |
| "The efficacy and acceptability of a single half-tablet daily of a fixed combination of 400 mg acebutolol and 25 mg hydrochlorothiazide was assessed in a study of 35 patients suffering from mild to moderate essential hypertension." | 5.05 | The efficacy and acceptability of the combination of acebutolol and hydrochlorothiazide in the treatment of essential hypertension. ( Sugeng, I; Suryaatmaja, M; Sutandar, H; Utama, H, 1984) |
| "Thirty patients with essential hypertension participated in a double blind crossover trial in which they were randomly allocated to treatment with either once daily slow release metoprolol (200 mg) with placebo or once daily slow release metoprolol (200 mg) with chlorthalidone (25 mg)." | 5.05 | Effect on intra-arterial blood pressure of slow release metoprolol combined with placebo or chlorthalidone. ( Altman, DG; Gould, BA; Hornung, RS; Kieso, HA; Mann, S; Raftery, EB, 1983) |
| "The effect of a single daily dose of timolol, hydrochlorothiazide and amiloride hydrochloride in fixed combination (Moducren; MDS) in patients with mild to moderate essential hypertension was tested during 1978 in an open study covering 10 weeks per patient." | 5.05 | Evaluation of a fixed combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A long-term multicentre trial. ( Pittaway, D, 1980) |
| "The antihypertensive effect of propranolol, in fixed combinations with two dosages of triamteren and hydrochlorothiazide (Dociteren), was evaluated in a double-blind test on 19 patients with uncomplicated essential hypertension." | 5.05 | [Propranolol, triamteren and hydrochlorothiazide in fixed combinations in the treatment of hypertension (author's transl)]. ( Herrmann, JM; Hiemstra, S; Hoenig, B, 1981) |
| "The dose response curve for 25, 50, 75 and 100 mg doses of chlorthalidone was studied in double blind fashion over an 8 week period in patients who presented with untreated mild hypertension." | 5.05 | Chlorthalidone in mild hypertension - dose response relationship. ( Humphries, IS; Mayhew, SR; Russell, JG, 1981) |
| "Twentysix women with pregnancy-induced hypertension have been randomly treated with either labetalol or Aldomet." | 5.05 | Comparison of the alpha and beta blocking drug, labetalol, and methyl dopa in the treatment of moderate and severe pregnancy-induced hypertension. ( Broughton Pipkin, F; Lamming, GD; Symonds, EM, 1980) |
| "Plasma urea and urate concentrations were determined daily for up to seven days in 40 pregnant women who had been admitted to hospital because of proteinuric hypertension and who were then allocated at random to either complete rest in bed or to being allowed to move freely in the ward." | 5.05 | The effect of rest and ambulation on plasma urea and urate levels in pregnant women with proteinuric hypertension. ( Agarwal, V; Mathews, DD; Shuttleworth, TP, 1980) |
| "Captopril (Capoten; Squibb) 100 mg was given as once-daily monotherapy in 20 patients with hypertension and hyperuricaemia." | 5.05 | Captopril once daily in patients with essential hypertension and hyperuricaemia. ( Acosta-Barrios, T; Leary, WP; Maharaj, B; Reyes, AJ, 1985) |
| " No significant differences were found for blood pressure, heart rate, body weight or serum uric acid." | 5.04 | Comparison between metoprolol and propranolol as antihypertensive agents. A double-blind cross-over study. ( Bengtsson, C, 1976) |
| " Nineteen patients with moderate arterial hypertension were treated for 5 consecutive weeks in a randomized fashion in a double-blind study with either tienilic acid or hydrochlorothiazide." | 5.04 | Treatment of arterial hypertension with tienilic acid, a new diuretic with uricosuric properties. ( Beauchemin, M; Gougoux, A; Lemieux, G; Vinay, P, 1978) |
| "This study was designed to compare the effectiveness of spironolactone, hydrochlorothiazide, and combined spironolactone-hydrochlorothiazide therapy in patients with low renin and those with normal renin essential hypertension." | 5.04 | Diuretic therapies in low renin and normal renin essential hypertension. ( Brooks, CS; Johnson, CA; Kotchen, JM; Kotchen, TA, 1977) |
| "In a double-blind study, 28 patients having mild to moderate essential hypertension were randomly assigned to a 6-week regimen of ticrynafen, hydrochlorothiazide, or placebo." | 5.04 | Ticrynafen and hydrochlorothiazide in hypertension. ( Beg, M; Okun, R, 1978) |
| " A double-blind comparison of the effect of tienylic acid and hydrochlorothiazide on blood pressure was made in patients with moderate hypertension." | 5.04 | A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension. ( Gillies, AH; Morgan, TO, 1978) |
| "A double-blind study of hydrochlorothiazide and spironolactone, alone and in combination, was conducted in 49 patients with mild-to-moderate essential hypertension after a 4-wk placebo washout period." | 5.04 | Hydrochlorothiazide and spironolactone in hypertension. ( Schrijver, G; Weinberger, MH, 1979) |
| "A new hypouricemic diuretic (tienilic acid) was compared with hydrochlorothiazide in a double-blind study in 8 patients with mild essential hypertension." | 5.04 | [Experiences with a new hypouricemic diuretic (tienilic acid): comparison with hydrochlorothiazide]. ( Furrer, J; Siegenthaler, W; Vetter, W, 1978) |
| "Timolol, 10 to 40 mg daily, given to 103 patients with uncomplicated arterial hypertension induced significant increments of serum potassium at all dose levels (p less than 0." | 5.04 | Serum potassium and uric acid changes during treatment with timolol alone and in combination with a diuretic. ( Mikkelsen, E; Pedersen, OL, 1979) |
| "In a double-blind study, thirty patients having mild to moderate essential hypertension were randomly assigned to a six week regimen of either tienilic acid, hydrochlorothiazide, or placebo." | 5.04 | A double-blind study of tienilic acid with two year follow-up of patients with mild to moderate essential hypertension. ( Beg, MA; Okun, R, 1979) |
| "The purpose of this double-blind study was to compare the effects on blood pressure of tienilic acid and hydrochlorothiazide in patients with essential hypertension." | 5.04 | Long-term usage of tienilic acid in essential hypertension. ( Beg, MA; Noble, RE, 1979) |
| " These initial studies demonstrate that tienilic acid is safe and effective in the treatment of mild to moderate essential hypertension, salt and water retention states, including oedema associated with congestive cardiac failure or mild to moderate renal dysfunction, and in the management of elevated serum uric acid levels associated with gout." | 5.04 | Safety of tienilic acid. ( Beg, MA; Ragland, R, 1979) |
| "Fifty-three pregnant women with moderately severe hypertension were randomly allocated to treatment with methyldopa or oxprenolol." | 5.04 | Randomised comparison of methyldopa and oxprenolol for treatment of hypertension in pregnancy. ( Gallery, ED; Györy, AZ; Hunyor, SN; Saunders, DM, 1979) |
| "A crossover comparison of metoprolol and hydrochlorothiazide has been performed in 20 patients with mild hypertension." | 5.04 | Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents. ( Pedersen, OL, 1976) |
| "The effect on BP of 100 and 200 mg spironolactone/day has been compared with that of methyl-dopa, 750 mg/day, and with combined treatment with both drugs in 32 patients with essential hypertension." | 5.04 | The effect of spironolactone (Aldactone) and methyldopa in low and normal renin hypertension. ( Giezendanner, L; Solheim, SB; Sundsfjord, JA, 1975) |
| " The current obesity epidemic has in fact made it relatively frequent even among children and adolescents to find some cardiovascular risk factors known in adults such as arterial hypertension, dyslipidemia, glucose metabolism disorders and increased of uric acid values." | 5.01 | Prevention of Cardiovascular Diseases in Children and Adolescents. ( Battaglino, MG; Genovesi, S; Giussani, M; Nava, E; Orlando, A; Parati, G, 2019) |
| "This review brings together concepts of uric acid metabolism affecting renal parenchyma and its function and the current therapies to reduce hyperuricemia (HyU) and avoid renal disease progression." | 4.98 | Uric Acid: The Unknown Uremic Toxin. ( Treviño-Becerra, A, 2018) |
| " For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome." | 4.98 | Uric Acid as a Cause of the Metabolic Syndrome. ( Jensen, T; Johnson, RJ; King, C; Lanaspa, MA; Sánchez-Lozada, LG; Tolan, DR, 2018) |
| "Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome through the oxidative stress and the inflammatory response induced by XOR-derived reactive oxygen species and uric acid." | 4.98 | The role of xanthine oxidoreductase and uric acid in metabolic syndrome. ( Battelli, MG; Bolognesi, A; Bortolotti, M; Polito, L, 2018) |
| " When compared with other combinations, the combination of ACEIs/ARBs and CCBs had comparable WMD of systolic as well as diastolic BP (73 study arms) but provided better benefits on metabolic parameters, such as HDL, FBS, HbA1C, and serum uric acid; renal functions, including serum creatinine and estimated glomerular filtration rate; and cardiovascular diseases, including reduction of all cardiovascular events, myocardial infarction, and syncope/hypotension." | 4.98 | The benefits of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers combined with calcium channel blockers on metabolic, renal, and cardiovascular outcomes in hypertensive patients: a meta-analysis. ( Eiam-Ong, S; Pitakpaiboonkul, P; Pongpanich, P; Praditpornsilpa, K; Susantitaphong, P; Takkavatakarn, K, 2018) |
| "Several epidemiological studies have demonstrated the existence of a correlation between high serum uric acid (SUA) levels, hypertension, and chronic kidney disease (CKD)." | 4.95 | The Effect of Xanthine Oxidase Inhibitors on Blood Pressure and Renal Function. ( Borghi, C; Bove, M; Cicero, AFG, 2017) |
| "These results support that allopurinol decreases BP and creatinine levels in patients with hyperuricemia." | 4.95 | Effect of uric acid-lowering therapy on blood pressure: systematic review and meta-analysis. ( Chen, JH; Jiang, H; Qu, LH, 2017) |
| "Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases." | 4.95 | Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review. ( Astell-Burt, T; Chen, S; Duan, D; Duan, S; Feng, X; Gu, K; Han, L; Liu, Y; Lu, N; Ma, J; Tang, L; Wang, C; Wang, K; Wen, Q; Xu, G; You, D; Zhang, L; Zhang, T, 2017) |
| " In addition, various other abnormalities such as inflammation, oxidative stress, and elevated levels of uric acid are also part of this syndrome." | 4.95 | Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation. ( Akolkar, G; Ayyappan, P; Bagchi, A; Belló-Klein, A; Bernardes, N; da Silva Dias, D; De Angelis, K; Singal, PK, 2017) |
| "Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease." | 4.93 | Uric acid in metabolic syndrome: From an innocent bystander to a central player. ( Jensen, T; Johnson, RJ; Kanbay, M; Lanaspa, MA; Le, M; Nakagawa, T; Rivard, C; Roncal-Jimenez, C; Solak, Y, 2016) |
| "In gouty patients, urate lowering therapies (ULTs) are recommended to bring serum uric acid (SUA) levels below 6." | 4.91 | Why focus on uric acid? ( Johnson, RJ, 2015) |
| " The link between increased fructose consumption and increases in uric acid also has been confirmed as a potential risk factor for metabolic syndrome, and insulin resistance/hyperinsulinemia may be causally related to the development of hypertension." | 4.91 | Health implications of high-fructose intake and current research. ( de Lima, WG; Dornas, WC; Pedrosa, ML; Silva, ME, 2015) |
| "To discuss the evolving data regarding uric acid as a potential cause of hypertension and progressive renal dysfunction and its clinical and research implications." | 4.90 | Serum uric acid and the risk of hypertension and chronic kidney disease. ( Feig, DI, 2014) |
| "We searched MEDLINE, EMBASE, CBM (Chinese Biomedicine Database) through September 2013 and reference lists of retrieved studies to identify cohort studies and nested case-control studies with uric acid levels as exposure and incident hypertension as outcome variables." | 4.90 | Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. ( Chen, J; Huang, H; Li, J; Li, Y; Qin, T; Wang, J; Wang, L, 2014) |
| "Elevated serum uric acid concentration is a common laboratory finding in subjects with metabolic syndrome/obesity, hypertension, kidney disease and cardiovascular events." | 4.89 | Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? ( Kapusta, DR; Rasheed, K; Reisin, E; Soltani, Z, 2013) |
| "Studies have shown an association between hyperuricemia and essential hypertension in children, presenting the possibility for serum uric acid level to serve as a biomarker for diagnosis and potential treatment target." | 4.89 | Serum urate: a biomarker or treatment target in pediatric hypertension? ( Feig, DI; Yanik, M, 2013) |
| "Over the last decade, the biologic interference of uric acid with the cardiovascular (CV) system and the kidney has been intensively investigated, and several experimental studies in animal models and in vitro documented that hyperuricemia may trigger hypertension and incite endothelial dysfunction, vascular damage and renal disease." | 4.89 | Uric acid, hypertension, and cardiovascular and renal complications. ( Mallamaci, F; Zoccali, C, 2013) |
| " Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD." | 4.89 | Serum uric acid and chronic kidney disease: the role of hypertension. ( Dehghan, A; Franco, OH; Hofman, A; Hoorn, EJ; Sedaghat, S; van Rooij, FJ; Witteman, JC, 2013) |
| "A number of epidemiological studies have reported an association between serum uric acid levels and a wide variety of high-risk conditions including hypertension, insulin resistance, and kidney and cerebro-cardiovascular disease." | 4.88 | Cardiovascular and renal effects of hyperuricaemia and gout. ( Leoncini, G; Pontremoli, R; Viazzi, F, 2012) |
| "With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development." | 4.88 | Uric acid as one of the important factors in multifactorial disorders--facts and controversies. ( Feher-Turkovic, L; Marinkovic, N; Pasalic, D, 2012) |
| "Thiazide and thiazide-like diuretics are widely used in the management of hypertension, but recently the equivalence of hydrochlorothiazide and chlorthalidone for blood pressure (BP) lowering and prevention of cardiovascular disease has been questioned." | 4.88 | Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate. ( Chaturvedi, N; Hardy, R; Hughes, AD; Peterzan, MA, 2012) |
| "Uric acid has been suspected to be a risk factor for hypertension since the 1870s." | 4.88 | The role of uric acid in the pathogenesis of hypertension in the young. ( Feig, DI, 2012) |
| "Uric acid (UA) increase is considered an important risk factor for the development of cardiovascular disease (CVD) favoring oxidative stress and endothelial dysfunction and is also involved in metabolic syndrome (MS) pathophysiology." | 4.88 | The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome. ( Dichi, I; Lozovoy, MA; Simão, AN, 2012) |
| " Fructose induces systemic hypertension through several mechanisms mainly associated with deleterious effects on target organs (kidney, endothelium, heart) exerted by the byproducts of its metabolism, such as uric acid." | 4.87 | Dietary fructose and hypertension. ( Jalal, D; Johnson, RJ; Madero, M; Perez-Pozo, SE; Sánchez-Lozada, LG, 2011) |
| " However, emerging data suggest that elevated uric acid (UA) is actually one of the most important factors for cardiovascular disease and that it also plays a significant role in the development of renal disease and metabolic syndrome." | 4.87 | Uric acid as a cardiometabolic risk factor: to be or not to be. ( Afsar, B; Covic, A; Kanbay, M, 2011) |
| "High uric acid (UA) levels can cause gout, urolithiasis and acute and chronic nephropathy, all of which are due to the deposit of urate crystals." | 4.87 | Is there anything good in uric acid? ( Alvarez-Lario, B; Macarrón-Vicente, J, 2011) |
| "Uric acid is a terminal metabolite of the degradation of nucleotides, which increases their blood levels in patients with preeclampsia-eclampsia, increasing its synthesis by damage and death of trophoblastic cells in proliferation and decreased urinary excretion due a lower glomerular filtration rate and increased absorption in the proximal tubule." | 4.87 | [Role of uric acid in preeclampsia-eclampsia]. ( Rico-Trejo, EI; Vázquez-Rodríguez, JG, 2011) |
| "A link between serum uric acid and the development of hypertension was first hypothesized in the 1870s." | 4.87 | Uric acid and hypertension. ( Feig, DI, 2011) |
| "Recently, much attention of medical professionals is directed to correlations between hyperuricemia, arterial hypertension, metabolic syndrome and renal affection because of the evidence that elevated blood level of uric acid raises the risk of cardiovascular complications not only in arterial hypertension and metabolic syndrome but also in diabetes mellitus type 2, coronary heart disease, congestive heart failure and renal dysfunction." | 4.87 | [Lozartan potential in hyperuricemia correction]. ( , 2011) |
| "Uric acid was first associated with primary hypertension in 1874, yet its role in this condition remains unclear." | 4.86 | Uric acid and hypertension: cause or effect? ( Feig, DI; Jalal, D; Johnson, RJ; Kanbay, M; Mazzali, M; Segal, MS; Shafiu, M, 2010) |
| "After uric acid was recognized as the causative factor in gout, increased prevalence of renal disease and hypertension in this patient population caught the attention of the medical community." | 4.86 | Uric acid in hypertension and renal disease: the chicken or the egg? ( Covic, A; Dogan, E; Kanbay, M; Lanaspa, MA; Solak, Y, 2010) |
| "Elevated serum uric acid is a marker for decreased renal function, may have a mechanistic role in the incidence and progression of renal functional decline and likely has a causal role in hypertension and vascular disease." | 4.85 | Uric acid: a novel mediator and marker of risk in chronic kidney disease? ( Feig, DI, 2009) |
| "After adjustment for age, body mass index, and other covariates, the relative risks (RRs) of developing hypertension comparing the highest and lowest uric acid quartiles were 1." | 4.85 | Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis. ( Hu, FB; Hui, R; Sun, K; Yang, Y; Zhang, H; Zhang, W, 2009) |
| " Early markers of CVD such as microalbuminuria and uric acid levels need to be added to the routine annual evaluation, particularly among high-risk individuals such as diabetics, hypertensives, smokers, and the elderly." | 4.85 | Chronic kidney disease: a marker of cardiovascular disease. ( Nguyen, PT; Olivero, JJ, 2009) |
| " Specifically, we review newly discovered mechanisms of uric acid-induced inflammation, uric acid's putative role as a "danger signal" in innate immunity, the possible link between hyperuricemia and cardiovascular disease, and evolutionary evidence suggesting that hyperuricemia conferred a survival advantage in primates (when the gene for uricase was lost) several million years ago." | 4.84 | Update on gout: pathophysiology and potential treatments. ( Abeles, AM; Cronstein, BN; Park, JY; Pillinger, MH, 2007) |
| "The level of serum uric acid in human has been increasing over the last decades, and correlates with an increase prevalence of renal disease and metabolic syndrome." | 4.84 | The conundrum of hyperuricemia, metabolic syndrome, and renal disease. ( Cirillo, P; Gersch, M; Johnson, RJ; Mu, W; Nakagawa, T; Roncal, C; Sánchez-Lozada, LG; Sato, W; Sautin, Y, 2008) |
| " Recently it has been identified that hypertension are frequently associated with myogenic hyperuricemia converted from overproduced hypoxanthine in the skeletal muscles." | 4.84 | [Idiopathic hyperuricemia with overproduction of uric acid]. ( Hisatome, I; Igawa, O; Mizuta, E, 2008) |
| "Epidemiologic studies published during the past 3 years support the possible role of uric acid in the onset of essential hypertension." | 4.83 | Uric acid and hypertension. ( Feig, DI; Johnson, RJ; Kang, DH; Mazzali, M; Nakagawa, T, 2006) |
| "In a retrospective chart review, we identified 95 children with confirmed, new onset hypertension, and evaluated the cause of hypertension and parental history of hypertension, birth weight, and serum uric acid." | 4.82 | Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. ( Feig, DI; Finch, J; Johnson, RJ; Kang, DH; Karumanchi, SA; Nakagawa, T; Oliver, WJ, 2004) |
| "This article critically evaluates the clinical evidence regarding the influence of uric acid on hypertension, cardiovascular disease, and kidney disease." | 4.82 | Clinical evidence for the influence of uric acid on hypertension, cardiovascular disease, and kidney disease: a statistical modeling perspective. ( Short, RA; Tuttle, KR, 2005) |
| "Many large epidemiological studies confirmed a positive association between raised serum uric acid (SUA) levels and risk of coronary heart disease (CHD) or cardiovascular disease (CVD) in the general population, among hypertensive patients and those with established CHD, stroke, diabetes and heart failure." | 4.82 | Serum uric acid and risk of coronary heart disease. ( Wannamethee, SG, 2005) |
| "Many large epidemiologic studies have confirmed a positive association between raised serum uric acid and risk of coronary heart disease or cardiovascular disease, both in the general population and among hypertensive patients." | 4.81 | Serum uric acid is not an independent risk factor for coronary heart disease. ( Wannamethee, SG, 2001) |
| "In patients with essential hypertension who have apparently normal renal function it is not unusual for the serum uric acid to be elevated." | 4.80 | Symptomless hyperuricaemia in patients with essential hypertension and normal renal function. ( Bradlow, A, 1998) |
| "The role of uric acid as an independent risk factor in the development of coronary heart disease (CHD) has been questioned as serum urate is related to many of the established etiological risk factors for cardiovascular disease which could confound the observed association." | 4.80 | Is serum uric acid a risk factor for coronary heart disease? ( Wannamethee, SG, 1999) |
| "Epidemiological studies show that serum uric acid is positively associated with blood pressure levels and that serum uric acid is also a predictor of the development of hypertension in normotensive adults." | 4.79 | [Hypertension and hyperuricemia]. ( Hirai, A; Saitoh, Y, 1996) |
| "The aims of this study were to evaluate the association between hypouricemia and cardiometabolic diseases, such as hypertension, dyslipidemia, and reduced kidney function, and to explore the sex-specific optimal range for serum uric acid (sUA) associated with the lowest risk for these diseases." | 4.31 | The Association Between Hypouricemia and Cardiometabolic Diseases: Analyzing Nationwide Data From Medical Checkup and Health Insurance Records. ( Kawakami, K; Koto, R; Kuwabara, M; Sato, I; Seki, T, 2023) |
| "Elevated serum uric acid (SUA) is associated with the incidence of hypertension, but whether relevant metabolic factors have mediating effects is not certain." | 4.31 | Association of serum uric acid with the risk of developing hypertension: A prospective cohort study with mediation analysis. ( Chu, X; Dong, J; Hu, LK; Liu, YH; Lu, YK; Yan, YX, 2023) |
| "In the frame of the Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on a regional community basis from all the territory of Italy under the patronage of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension, we searched for the cut-off values of the ratio between serum uric acid (SUA) and serum creatinine (sCr) able to predict cardiovascular (CV) events." | 4.31 | Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values. ( Angeli, F; Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'elia, L; Dell'Oro, R; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Lippa, L; Mallamaci, F; Maloberti, A; Masi, S; Masulli, M; Mazza, A; Mengozzi, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Reboldi, G; Rivasi, G; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2023) |
| "The authors examined the sex-specific association between serum uric acid (SUA) levels and achievement of target blood pressure among Japanese patients with hypertension." | 4.31 | Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension. ( Aoki, N; Fukuda, H; Hisaoka, T; Naito, T; Sato, Y; Suzuki, M; Yokokawa, H, 2023) |
| "Since both serum uric acid (SUA) and renal artery stenosis (RAS) are associated with atherosclerotic events and renal events, it is interesting to investigate whether SUA could predict long-term outcome in patients with RAS." | 4.31 | Concentration of serum uric acid in patients with Renal Artery Stenosis and Hypertension prEdict Future nephropathy and death: C-RASHEF study. ( Zheng, B, 2023) |
| "To explore the relationship between Dietary Approaches to Stop Hypertension (DASH) diet and serum uric acid (SUA) levels among the Chinese adult population, and verify the mediating effect of BMI between DASH diet and SUA levels." | 4.31 | Association between adherence to the Dietary Approaches to Stop Hypertension diet and serum uric acid. ( Cao, S; Feng, J; He, Y; Huang, Y; Ke, P; Lu, Z; Tian, Q; Wang, C; Wang, H; Xu, H, 2023) |
| "It is unclear whether uric acid (UA) has a negative or positive effect on anemia, and this may vary depending on the presence or absence of chronic disease such as hypertension (HTN)." | 4.31 | The relationship between anemia and hyperuricemia and hypertension in Korean adults: the Korea National Health and Nutrition Examination Survey 2016-2018. ( Cha, JA; Gi, MY; Park, CH; Park, SM; Park, SY; Sung, HH; Yoon, H, 2023) |
| "This study aims to investigate the relationship between serum uric acid levels and endothelial function, oxidative stress, and hemodynamic parameters, and to determine if uric acid levels provide additional insights beyond traditional factors like ageing and hypertension in volunteers with low cardiovascular risk factors." | 4.31 | Serum uric acid: a futile bystander in endothelial function? ( De Becker, B; Van De Borne, P, 2023) |
| "Higher serum uric acid (SUA) can cause gout, which is principally characterized by arthritis due to monosodium urate crystal deposition in the lower extremities." | 4.31 | Association between serum uric acid levels and peripheral artery disease in Chinese adults with hypertension. ( Bao, H; Cheng, X; Han, F; Hu, F; Huang, X; Wang, T; Yu, C; Zhou, W; Zhu, L, 2023) |
| "The aim of this study was to investigate the association between serum uric acid (UA) levels and hypertension in American individuals 20 years of age and older." | 4.31 | Relationship between serum uric acid and hypertension in the general US population aged 20 years and older: A cross-sectional study based on NHANES 2007 to 2016. ( Ouyang, Y; Wang, Y; Zhang, Y, 2023) |
| "Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population." | 4.31 | Serum uric acid is independently associated with hypertension in patients with polymyositis and dermatomyositis. ( Liu, M; Lu, K; Luo, Q; Wang, H; Zhao, T; Zhao, Z, 2023) |
| "To study the development of microalbuminuria (MAU) in essential hypertension (EHT), we investigated the association of MAU with central blood pressure (CBP), direct renin concentration (DRC), plasma aldosterone (PA), and uric acid (UA)." | 4.31 | Central diastolic blood pressure, plasma aldosterone and uric acid are associated with microalbuminuria in essential hypertension: a case-control study. ( Chou, H; Li, J; Li, Y; Shi, L; Wei, M; Yang, N, 2023) |
| "The relationship between uric acid (UA) and benign prostatic hyperplasia (BPH) is controversial and has rarely been studied in American populations." | 4.31 | Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008. ( Hao, X; Liu, X; Pan, Y; Xu, M; Xu, Z; Zhou, H, 2023) |
| "Serum uric acid is positively correlated with Gensini score in patients with coronary heart disease, which is an independent factor for evaluating the degree of coronary artery stenosis and has a predictive effect." | 4.31 | Uric acid and evaluate the coronary vascular stenosis gensini score correlation research and in gender differences. ( Luo, Y; Ma, K; Mao, M; Wu, F; Xiang, R; Yang, B; Yang, G, 2023) |
| "The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting combined (fatal and non-fatal) cerebrovascular (CBV) events in the whole database." | 4.12 | Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'elia, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Salvetti, M; Spinella, P; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2022) |
| "Whether hyperuricemia is a true risk factor for elevated blood pressure (BP) is controversial, and the sex-specific effects of serum uric acid (SUA) on BP during a follow-up period remain unclear." | 4.12 | Serum uric acid level is associated with an increase in systolic blood pressure over time in female subjects: Linear mixed-effects model analyses. ( Furuhashi, M; Hanawa, N; Higashiura, Y; Koyama, M; Mori, K; Ohnishi, H; Tanaka, M, 2022) |
| " It is may necessary to encourage people to check blood uric acid levels when they first time to be diagnosed with hypertension, especially in the elderly." | 4.12 | High prevalence and low awareness of hyperuricemia in hypertensive patients among adults aged 50-79 years in Southwest China. ( Fan, X; Hu, R; Huang, XB; Liu, JX; Liu, Y; Nie, FQ; Tang, W; Wang, TD; Wei, D; Xu, RH; Zhang, WQ; Zhang, Y, 2022) |
| " We aim to investigate the effect of overweight and/or obesity on high blood pressure (HBP), dyslipidemia, elevated serum uric acid (SUA) and their clustering among children and adolescents in an island in South China." | 4.12 | Body mass index was linked with multi-cardiometabolic abnormalities in Chinese children and adolescents: a community-based survey. ( Du, J; He, H; Jia, P; Jin, Y; Pan, L; Shan, G, 2022) |
| "The impact of serum uric acid (sUA) levels on the clinical prognosis and severity of coronary artery disease in patients with acute coronary syndrome (ACS) and hypertension after percutaneous coronary intervention (PCI) is not fully clear." | 4.12 | Impact of serum uric acid levels on the clinical prognosis and severity of coronary artery disease in patients with acute coronary syndrome and hypertension after percutaneous coronary intervention: a prospective cohort study. ( Liu, X; Shao, Y; Song, B; Yu, H; Zhang, S; Zhang, X, 2022) |
| "Elevated serum uric acid (UA) level has been shown to be influenced by multiple genetic variants, but it remains uncertain how UA-associated variants differ in their influence on hyperuricemia risk in people taking antihypertensive drugs." | 4.12 | Genetic risk of hyperuricemia in hypertensive patients associated with antihypertensive drug therapy: A longitudinal study. ( Chen, Y; Cui, B; Fu, L; Hui, R; Kong, T; Li, J; Wu, C; Yang, S; Yang, Y; Zhang, S; Zhang, W; Zhong, Y, 2022) |
| "This study is to investigate the correlation between serum uric acid levels and hyperhomocysteinemia Chinese adult patients with hypertension." | 4.12 | Serum uric acid concentration is associated with hyperhomocysteinemia in hypertensive Chinese adults. ( Wang, Q; Wang, W; Yang, N, 2022) |
| "Asymptomatic hyperuricemia (AHU) is elevated serum uric acid (UA) without symptoms." | 4.12 | Effects of uric acid-lowering therapy in patients with essential arterial hypertension. ( Bijak, M; Bilo, G; Drożdż, D; Drożdż, T; Gruszka, K; Hering, D; Jankowski, P; Rajzer, M; Terlecki, M; Wojciechowska, W, 2022) |
| "Children in the dyslipidemia group had more severe clinical characteristics (higher blood urea nitrogen, serum uric acid, and 24-h proteinuria; higher proportion of hypertension; and lower serum albumin and estimated glomerular filtration rate) and pathological changes (higher proportion of Lee grades IV-V and E1, S1, and C2 in MEST-C)." | 4.12 | Dyslipidemia may be a risk factor for progression in children with IgA nephropathy. ( Chen, L; Jiang, M; Jiang, X; Lin, Z; Xu, Y; Zeng, S; Zhuang, H, 2022) |
| " Potential factors associated with reduced renal function including age, ethnicity, educational level, history of diabetes, hypertension, gout, hydronephrosis, serum uric acid level, and type of renal stone were evaluated using univariable and multivariable analyses." | 4.12 | Cardiovascular risk factors, ethnicity and infection stone are independent factors associated with reduced renal function in renal stone formers. ( Choy, SH; J R, S; Kamaruzaman, S; Lim, J; Malek, R; Md Yusoff, NA; Nagappan, P; Nyanatay, SA; Ong, TA; Sothilingam, S; Sundram, M; Toh, CC; Yeoh, WS, 2022) |
| " Whereas Serum Uric acid acts as a marker of tissue infarction; indicating poor prognosis of ischemic stroke." | 4.12 | A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke. ( Bc, PK; Somannavar, VG, 2022) |
| " Indirect associations were mediated through the triglyceride-glucose (TyG) index (as an indicator of insulin resistance), mean arterial pressure (MAP), uric acid (UA), and total cholesterol (TC)." | 4.12 | The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia. ( Brozek, W; Concin, H; Fritz, J; Kerschbaum, J; Lhotta, K; Nagel, G; Ulmer, H; Zitt, E, 2022) |
| "The association of the metabolic syndrome with lithogenesis has been described, especially in uric acid stones." | 4.12 | Metabolic syndrome in calcium oxalate stones: Is it so important in this type of lithiasis? ( Arias Fúnez, F; Burgos Revilla, FJ; Duque Ruiz, G; Gomez Dos Santos, V; Hevia Palacios, M; Laso García, I; Sánchez Herranz, A, 2022) |
| "The role of uric acid as a risk factor for cerebrovascular disease, particularly acute ischemic stroke, is controversial and there is little information about this in our setting." | 4.12 | Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh. ( Hossain, MS; Jasmine, T; Kamrul-Hasan, AB; Rahman, MM; Saha, PK; Sarker, MA, 2022) |
| "The uric acid serum level is higher in people with hypertension and overweight/obesity." | 4.12 | Hyperuricaemia and its association with other risk factors for cardiovascular diseases: A population-based study. ( Baniasad, A; Najafipour, H; Najafzadeh, MJ; Shakibi, MR; Sistani, S; Yazdi, F, 2022) |
| "Hypertensive children with obesity had higher serum copeptin and uric acid and lower blood potassium levels." | 4.12 | Serum copeptin as a biomarker of hypertension in children with obesity. ( Bezen, D; Dursun, H; Gor, Z; Irdem, A; Turkmenoglu, Y; Vurgun, E, 2022) |
| " Hyperuricemia was defined as serum uric acid ≥ 7 mg/dL in men and ≥ 6 mg/dL in women." | 4.12 | The elevated visceral adiposity index increases the risk of hyperuricemia in Chinese hypertensive patients: A cross-sectional study. ( Bao, H; Cheng, X; Liu, H; Song, X; Wang, T; Yu, C; Zhou, W; Zhu, J; Zhu, L, 2022) |
| " Finally, we used multivariate linear regression to evaluate the relationship between serum leptin and eGFR levels with adjustment for age, sex, smoking status, drinking status, body mass index (BMI), uric acid levels, hypertension (HTN), diabetes mellitus (DM), and dyslipidemia." | 4.12 | Elevated serum leptin levels are associated with lower renal function among middle-aged and elderly adults in Taiwan, a community-based, cross-sectional study. ( Chen, JY; Chen, SY; Shih, CC; Shih, YL, 2022) |
| "This study aimed to investigate the adverse effects of serum uric acid concentration on the severity of chronic congestive heart failure." | 4.12 | The effect of serum uric acid concentration on the severity of chronic congestive heart failure. ( Al-Mohana, SJA; Alshamari, AHI; Kadhim, RK, 2022) |
| "Evidence is lacking about the role of serum uric acid (SUA) in the progression from prehypertension to hypertension." | 4.12 | Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study. ( Chen, S; Luo, Y; Mo, D; Tian, X; Wang, A; Wu, S; Zhang, L; Zuo, Y, 2022) |
| "Many studies have demonstrated that elevated serum uric acid independently increases the risk of developing hypertension." | 4.12 | Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study. ( Bai, Y; Bai, Z; Cheng, Z; Ding, J; Huang, P; Huang, W; Li, N; Liu, N; Wang, M; Wang, R; Wang, Y; Yang, J; Yin, C; Zhang, D; Zhang, R; Zheng, S, 2022) |
| "In the context of an aging population, this study aims to evaluate serum uric acid levels and arterial hypertension prevalence and control in a subgroup of Romanian adults (>65 years), concerning the influence of age on these parameters." | 4.02 | Arterial Hypertension and Serum Uric Acid in Elderly- SEPHAR III Study. ( Albulescu, N; Ardelean, M; Buzas, R; Dorobantu, M; Gheorghe-Fronea, OF; Ivan, VS; Lighezan, DF; Morgovan, AF, 2021) |
| " Hyperuricemia was defined as serum uric acid (SUA) level 420 umol/L in men and 360 umol/L in women." | 4.02 | Positive association between body fat percentage and hyperuricemia in patients with hypertension: The China H-type hypertension registry study. ( Bao, H; Cheng, X; Huang, X; Wang, S; Wangsheng, F; Xiong, Y; Zhou, W, 2021) |
| "Serum uric acid (SUA) has been found correlated with an increased risk of hypertension, but evidence is sparse regarding the association in Gansu Province, especially in Yugur people." | 4.02 | Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey. ( Chang, L; He, H; Pan, L; Ren, X; Shan, G; Wang, Y; Xi, J; Yu, C; Zhao, H, 2021) |
| "The elevated serum uric acid (SUA) is associated with an increased risk of hypertension and nutritional status." | 4.02 | The geriatric nutritional risk index mediated the relationship between serum uric acid and hypertension: a mediation analysis. ( Cao, Z; Dai, S; Liu, X, 2021) |
| " Nevertheless, the association between uric acid levels and the development of albuminuria has been under-investigated in patients with type 2 diabetes mellitus." | 4.02 | Association between uric acid level and incidence of albuminuria in patients with type 2 diabetes mellitus: A 4.5-year cohort study. ( Chen, LJ; Chen, YY; Ku, PW; Lai, YJ; Yen, YF, 2021) |
| "Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial." | 4.02 | The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults. ( Guo, X; Huang, J; Huang, Y; Ji, Q; Wu, S; Xu, X, 2021) |
| "We aimed to investigate the association between serum uric acid (SUA) level and development of hypertension as well as the interaction effect of chronic kidney disease (CKD) on this relationship in the general Japanese population." | 4.02 | Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study. ( Arima, H; Fujii, H; Funakoshi, S; Ishida, S; Ito, K; Kawanami, D; Kawazoe, M; Kondo, S; Maeda, T; Masutani, K; Mukobara, S; Nabeshima, S; Okutsu, S; Satoh, A; Tada, K; Takahashi, K; Tsuji, M; Yasuno, T; Yokota, S; Yoshimura, C, 2021) |
| "To assess the prognostic cut-off values of serum uric acid (SUA) in predicting fatal and morbid heart failure in a large Italian cohort in the frame of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension." | 4.02 | Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'Eliak, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Rattazzi, M; Rivasi, G; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2021) |
| "HHcy: hyperhomocysteinemia; Hcy: homocysteine; VLDL: very low-density lipoprotein; CVD: cardiovascular disease; SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; ALT: alanine aminotransferase; Cr: creatinine; UA: uric acid; TG: triglycerides; TC: total cholesterol; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FBG: fasting blood glucose; CRP: C-reactive protein; MTHFR: methylene tetrahydrofolate reductase; NO: nitric oxide; HDL-C: high-density lipoprotein cholesterol." | 4.02 | Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study. ( Chen, J; Hong, X; Li, J; Wang, J; Wu, M; Zeng, D; Zhang, D; Zhang, Y, 2021) |
| "In conclusion, after 1 year of non-pharmacological treatment, 23% of adolescents with sHT developed sustained hypertension, with the main predictor of cSBP change being the change in serum uric acid." | 4.02 | Evolution of isolated systolic hypertension with normal central blood pressure in adolescents-prospective study. ( Brzezińska, G; Feber, J; Litwin, M; Obrycki, Ł, 2021) |
| "The URic acid Right for heArt Health (URRAH) study is a nationwide, multicentre, observational cohort study involving data on individuals recruited from all the Italy territory under the patronage of the Italian Society of Hypertension with an average follow-up period of 122." | 4.02 | Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study. ( Barbagallo, CM; Bernardino, B; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'elia, L; Dell'Oro, R; Desideri, G; Facchetti, R; Ferri, C; Galletti, F; Giannattasio, C; Grassi, G; Iaccarino, G; Lippa, L; Loreto, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pauletto, P; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Rosei, EA; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2021) |
| "BACKGROUND Serum uric acid (UA) is involved in the development of hypertension." | 4.02 | U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study. ( Chen, K; Han, P; You, H; Yue, C; Zhao, X, 2021) |
| "Elevated serum uric acid (SUA) is associated with hypertension according to its traditional definition." | 4.02 | Elevated serum uric acid is associated with incident hypertension in the health according to various contemporary blood pressure guidelines. ( Hwang, JJ; Ke, SR; Liu, CW; Tseng, GS; Wu, YW, 2021) |
| "The relationship between uric acid and incident hypertension tended to be dependent on age and sex." | 4.02 | Age and sex dependent association of uric acid and incident hypertension. ( Choi, CU; Choi, JY; Go, TH; Kang, DO; Kang, DR; Kim, EJ; Kim, JY; Kim, W; Lee, J; Na, JO; Park, CG; Rha, SW; Roh, SY; Seo, HS, 2021) |
| "To evaluate the condition of subclinical cardiac damage in children with primary hypertension and the association between serum uric acid and subclinical cardiac damage." | 4.02 | [Association between serum uric acid and subclinical cardiac damage in children with primary hypertension]. ( Cao, L; Ding, YY; Hou, M; Lyu, HT; Shen, J; Sun, L; Xu, QQ; Yang, DP; Zhou, WP, 2021) |
| "Uric acid has long been considered responsible for a single specific disease, namely gout." | 4.02 | The URRAH study. ( Carubbi, F; Del Pinto, R; Ferri, C; Pontremoli, R; Russo, E; Viazzi, F, 2021) |
| "Patients with primary hypertension and without any uric acid (UA)-lowering treatment were enrolled." | 4.02 | Association of hyperuricemia and hypertension phenotypes in hypertensive patients without uric acid lowering treatment. ( Hou, J; Liao, H; Lin, J; Liu, C; Qiu, D; Zhang, M, 2021) |
| "Increased concentration of uric acid may play a role in the pathogenesis of primary hypertension (PH)." | 4.02 | [Uric acid in children and adolescents with primary hypertension]. ( Pańczyk-Tomaszewska, M; Skrzypczyk, P; Szyszka, M, 2021) |
| "We investigated serum uric acid changes and incident hyperuricemia in relation to the achieved blood pressure (BP) after 12 weeks of antihypertensive therapy with the irbesartan/hydrochlorothiazide combination." | 4.02 | Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination. ( Huang, QF; Li, Y; Wang, JG; Zhang, D, 2021) |
| "To explore whether dyslipidemia, hyperglycemia or hypertension has mediating effect on the association between serum uric acid (SUA) and the development of chronic kidney disease (CKD)." | 4.02 | The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis. ( Liu, L; Lv, X; Song, Y; Sun, H; Wang, S; Xu, L; Zhan, S, 2021) |
| " In this study, the differences between gout with cerebral infarction (gout+CI) and gout with coronary heart disease (gout+CHD) and related factors that affect serum uric acid (sUA) levels in gout+CI were investigated by a cross-sectional study." | 4.02 | Factors Influencing the Serum Uric Acid in Gout with Cerebral Infarction. ( Duan, L; Li, Y; Tian, Y; Yang, H, 2021) |
| "The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men." | 3.96 | Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Bruno, B; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'Elia, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Lippa, L; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Salvetti, M; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2020) |
| "d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver." | 3.96 | The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. ( Amézqueta, S; Atienza, L; Casas, J; Hereu, M; Medina, I; Miralles-Pérez, B; Muñoz, S; Ramos-Romero, S; Romeu, M; Torres, JL, 2020) |
| "Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0." | 3.96 | Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men. ( Cappuccio, FP; D'Elia, L; Galletti, F; Giaquinto, A; Iacone, R; Russo, O; Strazzullo, P, 2020) |
| "Leveraging a longitudinal cohort including 1981 Chinese adults who had blood pressures, urinary albumin to creatinine ratio (UACR), and uric acid measured twice 4 years apart, we examined the temporal relationships among hyperuricemia, microalbuminuria, and hypertension by cross-lagged panel analysis followed by a causal mediation analysis to confirm the temporal consequence." | 3.96 | Microalbuminuria mediates the association between serum uric acid and elevation of blood pressure: a longitudinal analysis in the Gusu cohort. ( He, Y; Jiang, Y; Li, J; Ma, S; Peng, H; Ren, L; Yu, J; Zhang, M; Zhang, Q, 2020) |
| " Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia and the predictors of sUA (serum uric acid) levels." | 3.96 | The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study. ( Gu, J; Huang, Y; Jiang, Y; Li, X; Liang, J; Ou, J; Song, W; Wei, Q, 2020) |
| "We investigate the association of uric acid with hypertension among Han, Uygur, and Kazakh populations in the Xinjiang Province of Western China." | 3.96 | Uric acid and its correlation with hypertension in postmenopausal women: A multi-ethnic study (Observational study). ( Chen, BD; Karmacharya, U; Liu, F; Ma, X; Ma, YT; Yuan, Q, 2020) |
| "High uric acid (UA) is associated with hypertension and cardiovascular disease (CVD), both of which occur disproportionately among African Americans." | 3.96 | Reactivity of salivary uric acid in response to social evaluative stress in African Americans. ( Buchalski, Z; Dawadi, A; Drolet, CE; Granger, DA; Lucas, T; Riis, JL, 2020) |
| " Previous studies have shown that high serum uric acid (SUA) levels are an independent risk factor for hypertension, cardiovascular disease (CVD), and ischemic stroke." | 3.96 | Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis. ( Bai, CX; Chen, JZ; Ge, J; Hui, RT; Li, H; Liu, TL; Song, L; Song, WH; Sun, YY; Wen, HY; Xiao, N; Xu, HC; Zhang, YH, 2020) |
| "The role of serum uric acid (SUA) in development of myocardial infarction (MI) is controversial." | 3.96 | Associations between changes in serum uric acid and the risk of myocardial infarction. ( An, J; Chen, S; He, Y; Li, H; Luo, Y; Tian, X; Wang, A; Wu, S; Zhang, L; Zuo, Y, 2020) |
| "Elevated serum uric acid increases the risk of hypertension, and individuals born preterm have higher blood pressure (BP) and uric acid, but the mechanisms remain unclear." | 3.96 | Association of circulating uric acid and angiotensin-(1-7) in relation to higher blood pressure in adolescents and the influence of preterm birth. ( Chappell, MC; Diz, DI; Jensen, ET; Nixon, PA; O'Shea, TM; Shaltout, HA; South, AM; Washburn, LK, 2020) |
| "Conclusions: Concentric and excentric left ventricular hypertrophy, increased left ventricular mass index proportionally to uric acid levels (r = 0,31; p = 0,04) is the confirmation of important role of hyperuricemia in the left ventricular hypertrophy development in patients with arterial hypertension." | 3.96 | Arterial hypertension associated with hyperuricemia: features of heart damage. ( Chernatska, OM; Fadieieva, HA; Liashenko, AV; Prystupa, LN; Smiianova, YO, 2020) |
| " This study was designed to evaluate the influences of long-term xanthine oxidase inhibitor (febuxostat) prescription on left ventricular hypertrophy (LVH), left ventricular (LV) diastolic function, and new-onset heart failure with preserved ejection fraction (HFpEF) in these patients." | 3.96 | Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia. ( Gu, J; Lin, H; Pan, JA; Wang, CQ; Zhang, JF, 2020) |
| "For 40 years many studies have been conducted to verify the connection between serum uric acid concentration and cardiovascular diseases, such as myocardial infarction." | 3.96 | The differential role of uric acid - The purpose or cause of cardiovascular diseases? ( Siemińska, E; Sikora, J; Skibińska, N; Sobczak, P, 2020) |
| "A significant relationship exists between elevated uric acid concentration and both prevalent and incident hypertension; however, data regarding the influence of higher uric acid concentration at baseline on blood pressure control by antihypertensive drugs is scarce." | 3.96 | Higher baseline uric acid concentration is associated with non-attainment of optimal blood pressure. ( Asahi, K; Fujimoto, S; Iseki, K; Kasahara, M; Kondo, M; Konta, T; Moriyama, T; Narita, I; Sato, Y; Shibagaki, Y; Tsuruya, K; Watanabe, T; Yamagata, K, 2020) |
| "To observe the changes in blood pressure (BP) over 10 years and to investigate current BP association to serum uric acid (SUA) levels and cardiovascular risk factors in the epidemiological data of a target group of patients with prehypertension in 2007." | 3.96 | Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study. ( Bawazier, LA; Irijanto, F; Kholiq, A; Sja'bani, M; Tomino, Y; Widiatmoko, A; Zulaela, Z, 2020) |
| "results indicate serum uric acid is positively correlated with hypertension and a reliable indicator of LVH in study population." | 3.96 | Serum uric acid and left ventricular hypertrophy in hypertensive patients in Ado-Ekiti. ( Adebayo, RA; Adewuya, OA; Ajayi, EA; Ojo, OE; Olaoye, OB, 2020) |
| " The definition of metabolic obesity phenotype includes elevated blood pressure, glucose, lipid, and uric acid levels and abnormal lipoprotein levels." | 3.91 | Metabolic Features of Individuals with Obesity Referred for Bariatric and Metabolic Surgery: a Cohort Study. ( Jin, L; Li, M; Liu, Y; Lv, H; Wang, L; Xu, W; Zeng, N; Zhang, M; Zhang, P; Zhang, Z; Zhao, K, 2019) |
| "To analyze the efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia." | 3.91 | Clinical efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia. ( Gao, H, 2019) |
| "This study shows, for the first time, that 1) an unexpectedly high percentage (69%) of overweight/obese subjects is affected by hypertension; 2) early hypertensive subjects have an increased eGFR and higher FT4 serum levels; 3) lower potassium and uric acid levels are independent predictors of pathological nocturnal non-dipping." | 3.91 | Uric Acid and Potassium Serum Levels Are Independent Predictors of Blood Pressure Non-Dipping in Overweight or Obese Subjects. ( Boninfante, B; Castellana, F; De Pergola, G; Giannelli, G; Lampignano, L; Lattanzio, A; Sardone, R; Zupo, R, 2019) |
| "Hyperuricemia is associated with cardiovascular disease, but the relationship between uric acid (UA) and pulse pressure (PP) is unclear." | 3.91 | Gender difference in the relationship between uric acid and pulse pressure among Korean adults. ( Jung, EY; Kim, HS; Moon, AE; Park, CE; Sung, HH; Yoon, H, 2019) |
| "Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension." | 3.91 | Age-differential association between serum uric acid and incident hypertension. ( Ahn, SV; Kim, HC; Lee, HY; Lee, SW; Nam, C; Oh, YA; Suh, I, 2019) |
| "In the Natural Medicines database, coenzyme Q10 (CoQ10) is classified as possibly effective for the treatment of hypertension." | 3.91 | Antihypertensive Potential of Coenzyme Q10 via Free Radical Scavenging and Enhanced Akt-nNOS Signaling in the Nucleus Tractus Solitarii in Rats. ( Chen, HH; Cheng, PW; Ho, CY; Ho, WY; Lai, CC; Sun, GC; Tseng, CJ; Yeh, TC, 2019) |
| "023) after adjusting for confounding factors such as gender, body mass index, low-density lipoprotein, triglycerides, estimated glomerular filtration rate, absence or presence of diabetes, absence or presence of hypertension, and uric acid." | 3.91 | Osteoporosis is inversely associated with arterial stiffness in the elderly: An investigation using the Osteoporosis Self-assessment Tool for Asians index in an elderly Chinese cohort. ( Avolio, A; Butlin, M; Tan, I; Wang, W; Xuan, Y; Zhang, H; Zuo, J, 2019) |
| "To identify common uric acid (UA) trajectories in middle-aged adults and to examine their association with the risk of hypertension." | 3.91 | Distinct Uric Acid Trajectories Are Associated With Different Risks of Incident Hypertension in Middle-Aged Adults. ( Guo, X; Li, X; Li, Y; Ma, H; Qi, L; Wang, X, 2019) |
| " Of the 62% of q2w responders exhibiting persistent decreases in MAP, there were no significant differences in baseline age, sex, race, weight, body mass index, history of hypertension, hyperlipidemia, history of coronary artery disease, gout duration, MAP, serum urate, estimated glomerular filtration rate or urinary uric acid/creatinine ratio compared with those who did not lower MAP." | 3.91 | Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout. ( Choi, HK; Johnson, RJ; Lipsky, PE; Yeo, AE, 2019) |
| "Serum uric acid (SUA) had been associated with incident hypertension, but it is uncertain whether and to what extent the effect of SUA is mediated by other metabolic factors." | 3.91 | Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study. ( Cao, Z; Cheng, Y; Gao, Y; Li, S; Li, W; Sun, L; Wang, Y; Yang, H; Yu, P, 2019) |
| "Experimental evidence suggests a causal role of serum uric acid (SUA) in hypertension development." | 3.91 | Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults. ( Ali, N; Haque, N; Haque, T; Islam, F; Islam, S; Khanum, FA; Mahmood, S; Mosaib, G; Perveen, R; Rahman, S, 2019) |
| "The potential association between altered levels of plasma free amino acids (PFAAs) and uric acid (UA) with estimated glomerular filtration rate (eGFR) remains unknown among patients with hypertension." | 3.91 | Relationship of reduced glomerular filtration rate with alterations in plasma free amino acids and uric acid evaluated in healthy control and hypertensive subjects. ( Hase, R; Kikuchi, S; Mahbub, MH; Takahashi, H; Tanabe, T; Yamaguchi, N; Yamamoto, H, 2019) |
| "Although both regimens were effective for reducing BP, increasing amlodipine to 10 mg daily controlled hypertension without elevation of serum uric acid." | 3.88 | Prospective direct comparison of antihypertensive effect and safety between high-dose amlodipine or indapamide in hypertensive patients uncontrolled by standard doses of angiotensin receptor blockers and amlodipine. ( Okamura, K; Okuda, T; Shirai, K; Totake, N; Urata, H, 2018) |
| "The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia." | 3.88 | Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders. ( Cheng, X; Cui, L; Hou, X; Jia, Z; Li, C; Li, X; Liu, Z; Lu, J; Ma, L; Mi, QS; Ren, W; Sun, R; Tian, Z; Wang, C; Wang, X; Xin, Y; Yuan, X; Zhang, K, 2018) |
| " laboratory evidence of kidney function decline (reference indicator), uric acid, and hypertension in different patient groups, separated according to their baseline uProt levels and baseline eGFR." | 3.88 | Effects of topiroxostat in hyperuricemic patients with chronic kidney disease. ( Hatakeyama, Y; Horino, T; Ichii, O; Inoue, K; Matsumoto, T; Okuhara, Y; Shimamura, Y; Terada, Y, 2018) |
| "Heterogeneous results have been obtained in the relationship between serum uric acid (SUA) and target organ damage (TOD) in patients with hypertension." | 3.88 | Sex-related relationships between uric acid and target organ damage in hypertension. ( Casati, M; Falbo, R; Giannattasio, C; Grassi, G; Maggioni, S; Maloberti, A; Nava, S; Occhi, L; Panzeri, F; Signorini, S; Triglione, N, 2018) |
| "The present study explored the gender interaction on the risk of uric acid in the new development of hypertension." | 3.88 | Gender interaction of uric acid in the development of hypertension. ( Hosoya, T; Kuriyama, S; Maruyama, Y; Nishio, S; Sugano, N; Yokoo, T, 2018) |
| "The role of serum uric acid (SUA) as a prognostic marker for incident heart failure (HF) in hypertensive subjects is uncertain." | 3.88 | Serum uric acid as a potential marker for heart failure risk in men on antihypertensive treatment: The British Regional Heart Study. ( Lennon, L; Papacosta, O; Wannamethee, SG; Whincup, PH, 2018) |
| "The purpose of this study was to examine the association between serum uric acid (sUA) and the incidence of hypertension in nonmetabolic syndrome (non-MetS) subjects." | 3.88 | Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study. ( Chen, Q; Chen, WY; Huang, X; Wu, JN; Yin, YJ, 2018) |
| "The objective of the present study was to evaluate clinical implications of serum uric acid (UA) on the progression of heart failure with preserved ejection fraction (HFpEF) in hypertensive patients." | 3.88 | Serum uric acid is associated with incidence of heart failure with preserved ejection fraction and cardiovascular events in patients with arterial hypertension. ( Fan, YQ; Gu, J; Wang, CQ; Zhang, HL; Zhang, JF, 2018) |
| "Little is known about the relationship between high baseline serum uric acid (SUA) and incident hypertension in patients with type 2 diabetes (T2D)." | 3.88 | Relationship Between Serum Uric Acid and Incident Hypertension in Patients with Type 2 Diabetes. ( Amini, M; Aminorroaya, A; Ghanbari, H; Janghorbani, M, 2018) |
| "Increasing evidence has shown that albuminuria is related to serum uric acid." | 3.88 | Urinary excretion of uric acid is negatively associated with albuminuria in patients with chronic kidney disease: a cross-sectional study. ( Chen, W; Fu, C; Guo, H; Li, F; Lu, Y; Xiao, J; Ye, Z; Zhang, X; Zou, J, 2018) |
| "Serum uric acid levels were associated with the future incidence of hypertension, and the association was observed in the younger individuals, those without diabetes, and those with preserved high-density lipoprotein cholesterol levels in a worksite population of Japanese men." | 3.88 | Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. ( Goto, K; Inoue, M; Kansui, Y; Kitazono, T; Kiyohara, K; Matsumura, K; Morinaga, Y; Ohta, Y; Ohtsubo, T; Ooboshi, H, 2018) |
| "This paper aims to evaluate the association between serum uric acid (SUA) levels, arterial hypertension (HT) prevalence, blood pressure values control, kidney function and intima media thickness (IMT), as a surrogate marker of early atherosclerosis, in a representative group of Romanian adult population." | 3.88 | Serum uric acid and arterial hypertension-Data from Sephar III survey. ( Buzas, R; Dorobantu, M; Ivan, V; Lighezan, D; Tautu, OF, 2018) |
| "Elevated circulating uric acid has been postulated to play an important pathophysiological role in estrogen-progestin combined oral contraceptive (COC)-induced hypertension and endothelial dysfunction." | 3.88 | Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin. ( Areola, ED; Badmus, OO; Kim, I; Michael, OS; Olatunji, LA; Omolekulo, TE, 2018) |
| "Our objective was to determine if elevated uric acid (UA) is associated with postpartum hypertension (PP HTN) in women without chronic hypertension." | 3.88 | The association of hyperuricemia and immediate postpartum hypertension in women without a diagnosis of chronic hypertension. ( Dixon, L; Marrs, CC; Olson, G; Rahman, M, 2018) |
| "This study aimed to examine gender differences in the association between serum uric acid (SUA) and the risk of prediabetes in a longitudinal cohort." | 3.88 | Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study. ( Chen, S; Guo, X; Liu, J; Mu, Y; Tao, L; Zhang, J; Zhao, Z; Zou, D; Zou, X, 2018) |
| "According to multiple linear regression analysis, in hypertension group, fractional excretion of sodium (FEna) was negatively correlated with 24 hour urinary uric acid (24-hUur) and uric acid clearance rate (Cur) (beta coefficients [B]=-0." | 3.88 | The Association of Urinary Sodium and Potassium with Renal Uric Acid Excretion in Patients with Chronic Kidney Disease. ( Chen, W; Fu, C; Guo, H; Li, F; Lu, Y; Xiao, J; Ye, Z; Zhang, X; Zou, J, 2018) |
| "Elevated serum uric acid concentration has been associated with high blood pressure (BP) and hypertension." | 3.85 | Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study. ( Arts, IC; Bierau, J; Boonen, A; Pijnenburg, W; Scheepers, LE; Staessen, JA; Stehouwer, CD; Thijs, C, 2017) |
| "The mean eGFR was statistically significantly lower in patients with hyperuricemia than in those with normal uric acid levels (143 vs." | 3.85 | Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemia. ( Cutter, GR; Feig, DI; Howard, TH; Lebensburger, JD; Muntner, P, 2017) |
| "Little is known about the relationship serum uric acid (SUA) and hypertension in Chinese population." | 3.85 | An observational study on the relationship between serum uric acid and hypertension in a Northern Chinese population aged 45 to 59 years. ( Cheng, HY; Huang, XL; Liu, SS; Shi, YX; Yu, FN, 2017) |
| " Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension." | 3.85 | Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study. ( Arts, ICW; Boonen, A; Dagnelie, PC; Henry, RMA; Kroon, AA; Scheepers, LEJM; Schram, MT; Stehouwer, CDA; van der Kallen, CJH, 2017) |
| "Our aim was to investigate the association between serum uric acid (SUA) levels and the risk of first stroke in a Chinese population of hypertensive patients." | 3.85 | Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort. ( Cai, Y; Dong, Q; Fu, J; He, M; Huo, Y; Li, J; Qin, X; Shi, X; Tang, G; Wang, B; Wang, K; Wang, L; Xu, X; Yang, J; Zhang, C; Zhang, Y; Zhao, G; Zhao, M, 2017) |
| "Previous studies have examined the association between elevated serum uric acid (SUA) level and hypertension; however, the association in the Chinese elderly is still uncertain." | 3.85 | Association between serum uric acid level and hypertension in a Chinese elderly rural population. ( He, Y; Jiang, B; Liu, M; Wang, J; Wang, Y; Wu, L; Zeng, J; Zhang, D, 2017) |
| "To disclose the link between the composition of urolithiasis, especially that of uric acid calculi, and obesity, prediabetes, type 2 diabetes mellitus, and hypertension." | 3.85 | The Association of Uric Acid Calculi with Obesity, Prediabetes, Type 2 Diabetes Mellitus, and Hypertension. ( Chang, CC; Chu, FY; Ho, JL; Huang, PH; Ku, PW; Lin, YN; Su, MJ; Sun, JT; Yen, TH, 2017) |
| "An elevated serum uric acid concentration may be associated with hypertension, which is the leading cause of death worldwide." | 3.85 | Serum Uric Acid Concentrations Can Predict Hypertension: A Longitudinal Population-Based Epidemiological Study. ( Chen, C; Chen, Q; Mao, Y; Yang, T; Zheng, R, 2017) |
| "High serum uric acid (sUA) has been reported to be a risk factor for hypertension however, whether this is the case for all age groups is not clear." | 3.85 | The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort. ( Cheng, W; Golledge, J; Hou, Y; Hu, H; Li, H; Qian, Z; Tan, Y; Wang, Y; Wen, S; Yang, G, 2017) |
| "Hyperuricemia and angiotensin II (Ang II) may have a pathogenetic role in the development of hypertension and atherosclerosis as well as cardiovascular disease (CVD) and its prognosis." | 3.85 | Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRβ. ( Çetin, A; Kırça, M; Oğuz, N; Uzuner, F; Yeşilkaya, A, 2017) |
| "Patients with both hypertension and hyperhomocysteinemia, termed H-type hypertension, have a high risk for cardiocerebrovascular diseases." | 3.85 | Prevalence of Homocysteine-Related Hypertension in Patients With Chronic Kidney Disease. ( Li, Y; Lou, T; Ma, X; Peng, H; Wang, C; Ye, Z; Zhang, J; Zhang, Q, 2017) |
| "Serum uric acid (SUA) has been associated to incident hypertension and increased risk of cardiovascular diseases." | 3.85 | High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects. ( Borghi, C; Cicero, AF; D'Addato, S; Fogacci, F; Grandi, E; Rosticci, M, 2017) |
| "Serum uric acid (SUA) is an emerging risk factor for incident hypertension and type 2 diabetes." | 3.85 | Serum uric acid change and modification of blood pressure and fasting plasma glucose in an overall healthy population sample: data from the Brisighella heart study. ( Borghi, C; Bove, M; Cicero, AF; D'Addato, S; Fogacci, F; Giovannini, M; Rosticci, M; Urso, R, 2017) |
| "It is uncertain whether high-baseline uric acid (UA) or change in UA concentration over time is related to development of incident hypertension." | 3.85 | Baseline and Change in Uric Acid Concentration Over Time Are Associated With Incident Hypertension in Large Korean Cohort. ( Byrne, CD; Guallar, E; Kim, JY; Kim, SH; Lee, JY; Lee, SH; Ryu, S; Sung, KC; Wild, SH, 2017) |
| "Objective To explore the possible correlation between uric acid levels and leukoaraiosis (LA)." | 3.85 | The association of uric acid with leukoaraiosis. ( Cai, RW; Chen, YF; Huang, YH; Li, JJ; Li, MM; Lin, YY, 2017) |
| "Hcy, uric acid (UA) and creatinine (Cr) levels in the H-type hypertension group were significantly higher than those of the common hypertension group (t=4." | 3.85 | Analysis of metabolism-related indicators and MTHFR gene polymorphism in patients with H-type hypertension. ( Tang, Z; Wang, JQ; Xiao, L; Zhang, T, 2017) |
| " Cox regression analysis showed that the baseline clinical and biochemical variables which associated with MACE were age, being illiterate, a widow or widower, and/or economically dependent, having triple vessel disease, stent implantation, anemia, and/or diabetes mellitus, waist to hip ratio (WHR), diastolic blood pressure, fasting glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), creatinine, estimated glomerular filtration rate (eGFR), red blood cell count, hemoglobin, hematocrit, and mean corpuscular-hemoglobin concentration (MCHC) in ACS patients, and age, malnourished, and/or economically dependent, taking hypoglycemic medication, having triple vessel disease, stent implantation, anemia, diabetes mellitus, and/or hypertension, WHR, fasting glucose, HDL-C, uric acid, creatinine, eGFR, high-sensitivity C-reactive protein, mean corpuscular volume, and MCHC in elective PCI patients." | 3.85 | The burden of major adverse cardiac events in patients with coronary artery disease. ( Chung, FM; Hsu, CC; Hung, WC; Lee, YJ; Lu, LF; Lu, YC; Tsai, IT; Wang, CP; Wu, CC; Yu, TH, 2017) |
| "Uric acid (UA) may not only prevent development of cognitive dysfunction owing to its antioxidant efficacy, but also may worsen cognitive functions by gaining pro-oxidant character." | 3.85 | Uric acid may be protective against cognitive impairment in older adults, but only in those without cardiovascular risk factors. ( Isik, AT; Kaya, D; Soysal, P; Tuven, B; Unutmaz, G, 2017) |
| "To evaluate the effect of hyperuricemia (HU) on subclinical changes of left ventricle (LV) function and structure in patients with hypertension (HT) using three-dimensional speckle-tracking echocardiography (3DSTE) and to explore the relationships between serum uric acid (SUA) levels and three-dimensional speckle tracking echocardiography (3DSTE) parameters in hypertensive and nonhypertensive patients with HU." | 3.85 | Assessment of subclinical left ventricular changes in essential hypertensive patients with hyperuricemia: A three-dimensional speckle-tracking echocardiography study. ( Chen, Y; Fang, X; Jiang, L; Pan, C; Shu, X; Sun, M; Wang, X; Zhang, Z, 2017) |
| "The association between serum uric acid (SUA) and left ventricular hypertrophy (LVH) is controversial and the ability of SUA in predicting incident LVH remains unsettled." | 3.85 | Uric Acid and New Onset Left Ventricular Hypertrophy: Findings From the PAMELA Population. ( Bombelli, M; Cuspidi, C; Facchetti, R; Grassi, G; Mancia, G; Sala, C; Tadic, M, 2017) |
| "The association of serum uric acid (SUA) with risk of hypertension is controversial and may be modulated by lifestyle factors." | 3.85 | Regular physical activity prevents development of hypertension in young people with hyperuricemia. ( Casiglia, E; Fania, C; Garavelli, G; Mos, L; Palatini, P; Saladini, F, 2017) |
| " The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized." | 3.85 | Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan. ( Komatsu, H; Kuwahara, E; Maejima, F; Murakami, Y; Nakazawa, A; Nishigaki, Y; Nishiwaki, Y; Okamura, T; Ushiku, H, 2017) |
| "The objective was to determine whether serum uric acid concentrations were associated with metabolic syndrome in a population from Wuhan." | 3.85 | Positive association between metabolic syndrome and serum uric acid in Wuhan. ( Chen, M; Fan, ZF; Fu, YQ; Li, D; Wang, L; Yang, H; Zeng, W; Zeng, XY; Zheng, JS, 2017) |
| "The purpose of this study is to investigate the effect of urate-lowering therapies (ULTs) on renal uric acid excretion in gout patients." | 3.83 | Influence of urate-lowering therapies on renal handling of uric acid. ( Chen, H; Ji, Z; Jiang, L; Ma, L; Wei, L; Yu, Q; Zhang, Z, 2016) |
| "Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already been reported." | 3.83 | Uric acid blood levels and relationship with the components of metabolic syndrome in hypertensive patients. ( Kalogeropoulos, P; Karamanou, AG; Moustakas, G; Papavasileiou, MV; Patsianis, S; Pittaras, A, 2016) |
| "This cross-sectional study from January 2012 to December 2012 aimed to examine the sex-specific association between serum uric acid (SUA) levels/hyperuricemia and hypertension among Japanese patients." | 3.83 | Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286 Japanese Workers. ( Fujibayashi, K; Fukuda, H; Hisaoka, T; Isonuma, H; Jose, PA; Matsuo, H; Miwa, Y; Naito, T; Nakayama, A; Sanada, H; Suzuki, A; Uehara, Y; Yokokawa, H, 2016) |
| "It is controversial that uric acid (UA) levels are related to the severity of hypertension in preeclampsia (PE)." | 3.83 | The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia. ( Aliciguzel, Y; Elmas, O; Simsek, T, 2016) |
| "Longitudinal changes in uric acid levels were independently associated with the renal function decline in elderly patients with hypertension." | 3.83 | Influence of changes in serum uric acid levels on renal function in elderly patients with hypertension: a retrospective cohort study with 3.5-year follow-up. ( Chen, H; Huang, F; Lin, C; Lin, F; Zhang, H; Zhu, P, 2016) |
| " Donors with new-onset hypertension showed significantly lower birth weights and higher uric acid levels (P < 0." | 3.83 | Estimated nephron number of the remaining donor kidney: impact on living kidney donor outcomes. ( Reinke, P; Schachtner, T, 2016) |
| "Increased xanthine oxidase (XO) activity and uric acid levels are known to be associated with obesity and hypertension; however, it is not known if obesity is directly responsible for these associations in youth." | 3.83 | Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity. ( Fox, CK; Johnson, LA; Kelly, AS; Nathan, BM; Tam, HK, 2016) |
| "To investigate the related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia." | 3.83 | Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia. ( Lin, L; Wang, B; Zhao, C, 2016) |
| "In matched analysis, risk of ischaemic stroke increased by 15% for each 1 mg/dl increase in plasma uric acid [95% confidence interval (CI) 3%-28%], but was no longer significant after adjustment for cardiovascular risk factors, particularly history of hypertension." | 3.83 | Plasma uric acid concentrations and risk of ischaemic stroke in women. ( Choi, HK; Curhan, GC; Forman, JP; Jiménez, MC; Rexrode, KM, 2016) |
| " Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other known risk factors." | 3.83 | Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study. ( Cai, C; Feng, S; Li, WD; Shi, W; Sun, N; Tian, J; Wang, Y; Wei, F; Xu, W; Yang, X, 2016) |
| "Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS)." | 3.83 | Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study. ( Eriksen, BO; Jenssen, TG; Norvik, JV; Solbu, MD; Storhaug, HM; Ytrehus, K; Zykova, SN, 2016) |
| " Multiple linear regression analysis using eGFR as the dependent variable demonstrated that uric acid (UA), FFA, triglyceride (TG), total cholesterol (TC), albuminuria, hypertension, smoking and duration of diabetes were all independent risk factors for decreased eGFR (all P<0." | 3.83 | [Correlation between serum free fatty acid level and estimated glomerular filtration rate in type 2 diabetic patients]. ( Li, H; Lin, X; Xuan, L; Yin, X; Zheng, F; Zhu, W, 2016) |
| "The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored." | 3.83 | Association between uric acid and renal function in hypertensive patients: which role for systemic vascular involvement? ( Castiglia, A; Cottone, S; Cusumano, C; D'Ignoto, F; Geraci, C; Geraci, G; Gervasi, F; Mogavero, M; Morreale, M; Mulè, G, 2016) |
| " To help understand the pathogenesis and early prevention of progressive CKD, this large-scale study is designed to determine the complex association between serum uric acid (SUA), metabolic syndrome and the prevalence of CKD in hypertensive patients." | 3.83 | Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients. ( Chen, R; Chen, Z; Dai, H; Liu, C; Lu, M; Lu, S; Lu, Y; Tang, X; Yang, P; Yuan, H; Zhou, H, 2016) |
| "Serum uric acid level is a predictor of future hypertension." | 3.83 | Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age. ( Kondo, T; Maeda, K; Murohara, T; Okumura, N; Osugi, S; Shimokata, K; Yokoi, Y, 2016) |
| " We evaluated the association between serum uric acid and uACR in persons with 0, and 1-2 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association." | 3.83 | The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome. ( Bruthans, J; Cifkova, R; Hamet, P; Krajcoviechova, A; Tahir, MR; Tremblay, J; Wohlfahrt, P, 2016) |
| "Pending confirmation, our findings suggest that variation in uric acid production, as captured by genetic variation in XOR, might be a predictor of changes in BP and in the risk of hypertension." | 3.83 | Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study. ( Arts, IC; Barlassina, C; Boonen, A; Casiglia, E; Cusi, D; Filipovský, J; Kawecka-Jaszcz, K; Malyutina, S; Manunta, P; Nikitin, Y; Salvi, E; Scheepers, LE; Staessen, JA; Stolarz-Skrzypek, K; Thijs, L; Tikhonoff, V; Wei, FF, 2016) |
| "At high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease." | 3.81 | Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes. ( Gonzales, GF; Tapia, V, 2015) |
| " The variables of the diagnostic rule (male sex, previous arthritis attack, onset <1 day, joint redness, involvement of the first MTP joint, hypertension or one or more cardiovascular disease, and serum uric acid >5." | 3.81 | The validation of a diagnostic rule for gout without joint fluid analysis: a prospective study. ( Fransen, J; Janssen, M; Janssens, HJ; Kienhorst, LB, 2015) |
| " Hyperuricemia was diagnosed by serum uric acid levels of >420 µmol/L in males or >357 µmol/L in females." | 3.81 | Association between serum uric acid and mortality in a Chinese population of hypertensive patients. ( Guo, X; Wang, J; Wang, Y; Zhao, D; Zhong, JQ, 2015) |
| "The purpose of this study was to examine the associations between serum uric acid (SUA) levels and the incidences of hypertension and metabolic syndrome (MetS) in a large screened cohort of Japanese men and women." | 3.81 | Associations between serum uric acid levels and the incidence of hypertension and metabolic syndrome: a 4-year follow-up study of a large screened cohort in Okinawa, Japan. ( Inoue, T; Kinjo, K; Kohagura, K; Nagahama, K; Ohya, Y, 2015) |
| "Serum uric acid (SUA) is associated with many cardiovascular risk factors such as hypertension (HTN) and metabolic syndrome (MetS)." | 3.81 | Serum uric acid levels are associated with hypertension and metabolic syndrome but not atherosclerosis in Chinese inpatients with type 2 diabetes. ( Bao, YQ; Dong, XH; Jia, WP; Li, LX; Li, MF; Li, TT; Shen, J; Zhang, R, 2015) |
| "Several studies have demonstrated a relationship between increased serum uric acid (SUA) concentrations and the prevalence of metabolic syndrome (MetS) in the oriental population." | 3.81 | Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study. ( Babio, N; Basora, J; Becerra-Tomás, N; Corella, D; Estruch, R; Fitó, M; Martínez-González, MA; Ortega-Calvo, M; Recondo, J; Ros, E; Salas-Salvadó, J; Serra-Majem, L; Wärnberg, J, 2015) |
| " Compared to women with normal fasting glucose (NFG), we found a dose-response relationship of the risk of prediabetes with age and body mass index (BMI) and total cholesterol, triglyceride, glutamic-pyruvic transaminase (GPT), and uric acid in serum." | 3.81 | Clinical risk factors of prediabetes in Taiwanese women without substance uses (tobacco, alcohol, or areca nut). ( Cheng, CM; Chiu, KF; Huang, CT; Hung, CC; Lee, CY; Lin, HH; Lin, PC; Lin, WY; Wu, MT; Wu, WC, 2015) |
| "The causal relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) has not yet been clarified." | 3.81 | Serum uric acid and non-alcoholic fatty liver disease in non-hypertensive Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study. ( Dou, LJ; Gong, Y; Liang, J; Liu, XK; Pei, Y; Qi, L; Qiu, QQ; Yang, MQ; Zou, CY, 2015) |
| "Inefficient renal excretion of uric acid is the main pathophysiological mechanism for hyperuricemia in gout patients." | 3.81 | Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients. ( Aniel-Quiroga, MA; Chinchilla, SP; Erauskin, GG; Herrero-Beites, AM; Merriman, T; Perez-Ruiz, F, 2015) |
| "Obesity and diets rich in uric acid-raising components appear to account for the increased prevalence of hyperuricemia in Westernized populations." | 3.81 | Uric Acid and Cardiovascular Events: A Mendelian Randomization Study. ( Delgado, G; Grammer, TB; Huang, J; Kleber, ME; Krämer, BK; März, W; Ritz, E; Silbernagel, G, 2015) |
| "The purpose of this study was to evaluate associations among hypertension (HTN) and uric acid (UA) with cardiovascular autonomic neuropathy (CAN), and to estimate the extent to which synergistic effects of HTN and UA affect the outcome in a Chinese population." | 3.81 | The association and interaction analysis of hypertension and uric acid on cardiovascular autonomic neuropathy. ( Liao, XP; Tang, ZH; Zeng, F; Zhu, HW, 2015) |
| "We recruited 43 chronic kidney disease (CKD) patients who did not receive RAS blockers and antihyperuricaemic drugs, and investigated the relationship among serum uric acid (sUA) levels, the circadian rhythm of urinary angiotensinogen (U-AGT) excretion levels, and the levels of albuminuria (U-ACR) and proteinuria (U-P/Cr)." | 3.81 | Hyperuricaemia is associated with renal damage independently of hypertension and intrarenal renin-angiotensin system activation, as well as their circadian rhythms. ( Ishigaki, S; Isobe, S; Iwakura, T; Kato, A; Ohashi, N; Ono, M; Sakao, Y; Tsuji, N; Tsuji, T; Yasuda, H, 2015) |
| " The PARTNER (Practical combination therapy of Amlodin and angiotensin II Receptor blocker; Safety and efficacy in paTieNts with hypERtension) study is a prospective specific clinical use survey examining the efficacy and safety of 12-week treatment with amlodipine (AML) and Angiotensin II Receptor Blocker (ARB) in 5900 hypertensive patients." | 3.81 | The therapeutic advantage of combination antihypertensive drug therapy using amlodipine and irbesartan in hypertensive patients: Analysis of the post-marketing survey data from PARTNER (Practical combination therapy of Amlodin and angiotensin II Receptor ( Fukuda, H; Ishibashi, K; Ishimitsu, T; Nagao, M; Nukui, K; Sato, F; Uchida, M, 2015) |
| " Linear regression was used to evaluate associations between uric acid and clinical and laboratory findings associated with metabolic syndrome." | 3.81 | [Metabolic complications of obesity during adolescence, particularly regarding elevated uric acid levels]. ( Almási, A; Barkai, L; Fehér, V; Kiss-Tóth, E; Ságodi, L, 2015) |
| "There are data describing that cardiovascular risks related to serum uric acid (SUA) levels may begin below the current diagnostic level for hyperuricemia." | 3.81 | Uric acid levels within the normal range predict increased risk of hypertension: a cohort study. ( Dinour, D; Holtzman, EJ; Leiba, A; Shani, M; Vinker, S, 2015) |
| "Uric acid (UA) is associated with high blood pressure in adolescents and with left ventricular hypertrophy (LVH) and cardiovascular disease (CVD) in adults." | 3.81 | Elevated uric acid and obesity-related cardiovascular disease risk factors among hypertensive youth. ( Appel, LJ; Brady, TM; Fadrowski, JJ; Holmes, KW; Loeffler, LF; Miller, ER; Reschke, LD, 2015) |
| "To explore the associations between urine uric acid excretion (UUAE) and diabetic retinopathy (DR)/lower limb atherosclerotic lesions in hospitalized Chinese patients with type 2 diabetes." | 3.81 | Decreased urine uric acid excretion is associated with diabetic retinopathy but not with lower limb atherosclerosis in hospitalized patients with type 2 diabetes. ( Bao, YQ; Chen, MY; Jia, WP; Li, LX; Li, TT; Lu, JX; Shuai, HP; Wang, JW; Xia, HF; Zhang, R, 2015) |
| "Serum uric acid (UA) is independently associated with hypertension and blood pressure (BP) variability (BPV) is associated with cardiovascular events and mortality in hypertensive patients." | 3.81 | Association of Serum Uric Acid Level With Blood Pressure Variability in Newly Diagnosed Essential Hypertension. ( Çağlı, K; Canpolat, U; Covic, A; Kanbay, M; Mendi, MA; Öksüz, F; Özcan, F; Siriopol, D; Tok, D; Turak, O; Veisa, G, 2015) |
| "The relationships between uric acid and chronic disease risk factors such as metabolic syndrome, type 2 diabetes mellitus, and hypertension have been studied in adults." | 3.81 | Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study. ( Chen, YL; Lue, KH; Pei, D; Sun, HL, 2015) |
| "Elevated serum uric acid (UA) could be a risk factor for hypertension, type 2 diabetes mellitus and cardiovascular disease." | 3.80 | Serum uric acid level is associated with the development of microalbuminuria in Korean men. ( Oh, CM; Park, SK; Ryoo, JH, 2014) |
| "Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance." | 3.80 | Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study. ( Borghi, C; Cicero, AF; D'Addato, S; Rosticci, M; Salvi, P, 2014) |
| "We assessed the effect of increased serum uric acid (SUA) concentration and hyperuricemia on subclinical organ damage." | 3.80 | Serum uric acid concentration and asymptomatic hyperuricemia with subclinical organ damage in general population. ( Li, Y; Lu, J; Wu, X; Yang, C, 2014) |
| "We tested the hypothesis that uric acid levels predict new-onset hypertension in the Japanese general population." | 3.80 | Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population. ( Dohi, Y; Kimura, G; Takase, H, 2014) |
| " Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD)." | 3.80 | Uric acid level and erectile dysfunction in patients with coronary artery disease. ( Akilli, H; Aribas, A; Covic, A; Gaipov, A; Johnson, RJ; Kanbay, M; Kayrak, M; McFann, K; Perez-Pozo, SE; Solak, Y; Turk, S, 2014) |
| "In the univariate analysis, the major risk factors for kidney dysfunction in the patients with the cardio-cerebrovascular disease were age, gender, hypertension, diabetes mellitus, dyslipidemia and serum uric acid." | 3.80 | High prevalence and risk factors for kidney dysfunction in patients with atherosclerotic cardio-cerebrovascular disease. ( Bao, YS; Ji, Y; Jia, XB; Na, SP; Yang, J; Zhao, SL, 2014) |
| " In the present study, blood triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) breakdown pathway was evaluated in relation to uric acid concentration and xanthine dehydrogenase/xanthine oxidase (XDH/XO) in patients with essential hypertension, patients with chronic renal diseases on dialysis, and control individuals." | 3.80 | Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease. ( Boban, M; Bobana, MD; Cvetkovic, T; Deljanin-Ilic, M; Djindjic, B; Ilic, S; Jevtovic-Stoimenov, T; Kocic, G; Pavlovic, R; Radenkovic, S; Sokolovic, D; Stojanovic, D, 2014) |
| "Serum uric acid (UA) is now beginning to be considered a risk predictor for cardiovascular diseases." | 3.80 | Serum uric acid as a risk predictor for erectile dysfunction. ( Heydari, R; Mehrsai, A; Pourmand, G; Salem, S, 2014) |
| "Among adults free of metabolic syndrome, elevated uric acid, but not elevated CRP, is independently associated with prevalent hypertension." | 3.80 | Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010. ( Krishnan, E, 2014) |
| " Despite evidence of uric acid-induced endothelial dysfunction, a relationship with insulin resistance has not been clearly established." | 3.80 | Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. ( Choi, YJ; Hien, TT; Kang, DH; Kang, KW; Kim, KC; Lee, BH; Lee, J; Lee, KY; Lee, MY; Lee, SM; Yoon, Y, 2014) |
| "The cause and effect relationship between serum uric acid levels and hypertension can be difficult to evaluate because antihypertensive drugs sometimes affect uric acid levels." | 3.80 | Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension. ( Asano, T; Hisatome, I; Komatsu, I; Kuwabara, M; Masuda, K; Mizuno, A; Nishi, Y; Niwa, K; Takahashi, O; Yamazoe, M, 2014) |
| "Uric acid has ever been considered as one of contrast induced acute kidney injury's risk factors." | 3.80 | Atorvastatin combining with probucol: a new way to reduce serum uric acid level during perioperative period of interventional procedure. ( Cong, H; Fu, N; Jin, D; Li, H; Li, X; Ma, H; Wang, Y, 2014) |
| " Systolic blood pressure, fasted plasma parameters, insulin sensitivity, plasma norepinephrine (NE), uric acid, and angiotensin II (Ang II) were determined following 9 weeks of treatment." | 3.80 | Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension. ( MacLeod, KM; McNeill, JH; Tran, LT, 2014) |
| "To assess the relationship between serum uric acid and target organ damage (left ventricular hypertrophy and microalbuminuria) in untreated patients with essential hypertension." | 3.80 | Serum uric acid and target organ damage in essential hypertension. ( Odia, OJ; Ofori, SN, 2014) |
| "The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients." | 3.80 | Prevention of comorbidity and acute attack of gout by uric acid lowering therapy. ( Joo, H; Joo, K; Jung, KH; Kwon, SR; Lim, MJ; Park, W, 2014) |
| "Serum uric acid levels have been reported to be associated with non-alcoholic fatty liver disease (NAFLD)." | 3.80 | Relationship between serum uric acid levels and hepatic steatosis in non-obese postmenopausal women. ( Chen, Y; Liu, PJ; Lou, HP; Ma, F; Zhu, YN, 2014) |
| "This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension." | 3.80 | Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension. ( Chen, B; Deng, W; Zhang, J; Zhang, Y, 2014) |
| " Hyperuricemia was defined as levels of uric acid >7." | 3.80 | Hyperuricemia and incident atrial fibrillation in a normotensive elderly population in Taiwan. ( Chia-Yu Chen, R; Chuang, SY; Hsu, PF; Hsu, YY; Liu, WL; Pan, WH; Wu, CC, 2014) |
| " The relationship between albuminuria and circulating biomarkers for both oxidative damage, that is carbonyl and malondialdehyde, as well as antioxidant defense, that is reduced glutathione, thiol groups, uric acid, bilirubin, or catalase, and superoxide scavenging activity, was assessed." | 3.80 | Development of albuminuria and enhancement of oxidative stress during chronic renin-angiotensin system suppression. ( Aranguez, I; Arribas, S; Cerezo, C; Condezo-Hoyos, L; Del Carmen Gónzalez, M; Fernández-Alfonso, MS; Praga, M; Pulido-Olmo, H; Ruilope, LM; Ruiz-Hurtado, G; Segura, J, 2014) |
| "To evaluate whether uric acid (UA) predicts 4-yr incidence of metabolic syndrome (MetS) in non-diabetic participants of the Strong Heart Study (SHS) cohort." | 3.80 | Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity. ( de Simone, G; Devereux, RB; Ferrara, LA; Franceschini, N; Howard, BV; Jolly, S; Lee, ET; Umans, JG; Wang, H; Yeh, J, 2014) |
| "To identify the risk factors of kidney injuries in hypertensive patients with uric acid (UA) metabolic disorders in order to choose the optimal management tactics, by analyzing the changes in markers for endothelial dysfunction (endothelin-1 (ET-1), microalbuminuria (MAU), intima-media thickness (IMT)) and tubulointerstitial tissue lesion (beta2-microglobulin (beta2-MG, monocyte chemotactic protein-1 (MCP-1))." | 3.80 | [Clinical value of the determination of markers for endothelial dysfunction (endothelin-1, microalbuminuria) and tubulointerstitial tissue lesion (β2-microglobulin, monocyte chemotactic protein-1) in hypertensive patients with uric acid metabolic disorder ( Balkarov, IM; Kozlovskaia, LV; Shcherbak, AV; Stakhova, TIu; Taranova, MV, 2014) |
| "To elucidate links of blood serum uric acid level (SUAL) with cardiometabolic risk factors (CMR) in adolescent boys with arterial hypertension (AH)." | 3.80 | [Uric acid and factors of cardiometabolic risk in adolescents with arterial hypertension]. ( Dolgikh, VV; Pogodina, AV; Rychkova, LV, 2014) |
| "High levels of serum uric acid are associated with hypertension in observational studies." | 3.80 | Association of uric acid genetic risk score with blood pressure: the Rotterdam study. ( Dehghan, A; Franco, OH; Hofman, A; Ikram, MA; Pazoki, R; Sedaghat, S; Stricker, BH; Uitterlinden, AG, 2014) |
| " The relationship between uric acid levels and left ventricular mass in hypertension, however, is unclear." | 3.80 | Uricaemia and left ventricular mass in hypertensive patients. ( Brosolo, G; Capobianco, F; Catena, C; Colussi, G; Sechi, LA, 2014) |
| " Of note, diabetic subjects with glycosuria, who represented 24% of the diabetic participants, had a null prevalence of hyperuricemia, and statistically higher values for fractional excretion of uric acid, Na excretion index, and prevalence of microalbuminuria than those without glycosuria." | 3.80 | Serum uric acid and disorders of glucose metabolism: the role of glycosuria. ( Andrade, JA; Garcia Rosa, ML; Greffin, S; Kang, HC; Lugon, JR, 2014) |
| "To study the correlation between lacunar cerebral infarction and level of serum uric acid in elderly male hypertension patients." | 3.80 | [Correlation between lacunar cerebral infarction and serum uric acid level in elderly male hypertension patients]. ( Cheng, L; Guan, WP; Jiang, L; Ma, Q; Wu, WP, 2014) |
| "We assessed whether red cell distribution width (RDW) is associated with serum uric acid (UA) level in a group of 512 patients with newly diagnosed hypertension, recruited in Beijing." | 3.80 | Relationship between red cell distribution width and serum uric acid in patients with untreated essential hypertension. ( Chen, LZ; Chen, P; Hu, YY; Li, YY; Li, ZZ; Luo, M; Yan, SP, 2014) |
| " Compared to those in normal serum uric acid group, the incidence of hypertension (33%, 16/48), serum triglyceride [2." | 3.80 | [Relationship between hyperuricemia and primary nephrotic syndrome in children]. ( Li, Q; Wang, F; Xiao, H; Yao, Y; Zhong, X, 2014) |
| " Lower measured GFR associated with lower 24-hour urine creatinine, albuminuria, hypertension, diabetes, higher triglycerides, and higher uric acid." | 3.79 | Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease. ( Bailey, KR; Lieske, JC; Peyser, PA; Rule, AD; Turner, ST, 2013) |
| "Uric acid may be involved in the pathogenesis of hypertension." | 3.79 | Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure. ( Chen, CH; Cheng, HM; Chou, P; Chuang, SY; Hsu, PF; Lakatta, EG; Sung, SH; Ting, CT; Yin, FC, 2013) |
| "Experimental and epidemiological studies have demonstrated that urinary angiotensinogen (AGT) is a novel biomarker for the intrarenal activity of the renin-angiotensin system in hypertension (HT)." | 3.79 | Urinary angiotensinogen as a marker of intrarenal angiotensin II activity in adolescents with primary hypertension. ( Kuroczycka-Saniutycz, E; Milewski, R; Sulik, A; Wasilewska, A, 2013) |
| "Uric acid may have a role in the development of hypertension and renal dysfunction." | 3.79 | Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. ( Dawson, J; Dominiczak, AF; Hastie, C; Hetherington, L; Jardine, A; Jeemon, P; Judd, C; McInnes, G; Morrison, D; Muir, S; Padmanabhan, S; Schulz, C; Sloan, W; Walters, M, 2013) |
| "There is an ongoing debate on the role of serum uric acid as an independent risk factor for hypertension and renal disease." | 3.79 | Serum uric acid levels among Nigerians with essential hypertension. ( Abdu, A; Emokpae, AM, 2013) |
| " We calculated the mean values for proteinuria and serum phosphate, calcium, uric acid, and PTH, as well as 24-hour urinary excretion of urea nitrogen over time for each patient." | 3.79 | Factors related with the progression of chronic kidney disease. ( Abad, S; Ampuero, J; Aragoncillo-Sauco, I; Barraca, D; López-Gómez, JM; Ruiz-Caro, C; Vega-Martínez, A; Verdalles-Guzmán, Ú; Yuste, C, 2013) |
| "The non-traditional risk factors for atherosclerotic lesions of the cardiovascular system (C-reactive protein, uric acid, fibrinogen, homocysteine) in blood plasma of patients with manifestative hypothyroidism at the age of 23 to 73 years were assessed in the study." | 3.79 | [Atypical risk factors of atherosclerosis in patients with hypothyroidism]. ( Mykhaĭlenko, OIu, 2013) |
| " Blood pressure, lipids, glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR) and uric acid levels were compared across BMI groups." | 3.79 | Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk. ( Brines, J; de Onis, M; Martínez-Costa, C; Montal, A; Nguefack-Tsague, G; Núñez, F, 2013) |
| " As a potentially modifiable risk factor, we examined whether serum uric acid levels correlate with early hypertension, kidney volume and progression to end-stage renal disease (ESRD) in autosomal-dominant polycystic kidney disease (ADPKD)." | 3.79 | Serum uric acid, kidney volume and progression in autosomal-dominant polycystic kidney disease. ( Fick-Brosnahan, GM; Helal, I; McFann, K; Reed, B; Schrier, RW; Yan, XD, 2013) |
| "Uric acid (UA) is independently associated with the emergence of hypertension." | 3.79 | Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. ( Aydoğdu, S; Işleyen, A; Johnson, RJ; Kanbay, M; McFann, K; Ozcan, F; Sen, N; Sökmen, E; Taşoğlu, I; Tok, D; Turak, O, 2013) |
| "Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke." | 3.79 | Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke. ( Kim, BJ; Kim, CK; Lee, SH; Ryu, WS, 2013) |
| " We assessed the prevalence of hyperuricemia and determined the independent risk factors for raised serum uric acid level by multiple logistic regression analyses." | 3.78 | Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan. ( Chang, SC; Chen, KF; Chi, WC; Hung, YJ; Lee, DY; Lee, WL; Lin, CS, 2012) |
| "Previous reports suggested that gout incidence increased with serum uric acid (sUA) level." | 3.78 | Gender-specific risk factors for incident gout: a prospective cohort study. ( Chen, JH; Chuang, SY; Pan, WH; Wu, YY; Yeh, WT, 2012) |
| ") isolated from Hibiscus rosa sinensis (Malvaceae) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, uric acid and insulin in fructose-induced hypertension model." | 3.78 | Effect of A-HRS on blood pressure and metabolic alterations in fructose-induced hypertensive rats. ( Khade, B; Mohan, M; Shinde, A, 2012) |
| " Since low urine pH is the main risk factor for uric acid urolithiasis (UAU), UAU may be regarded as a renal manifestation of the MS." | 3.78 | Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. ( Schubert, G; Strohmaier, WL; Wrobel, BM, 2012) |
| " Overall serum uric acid (UA) concentration increased, whereas in patients with hyperuricemia there was a significant reduction in this value." | 3.78 | Antihypertensive effect of a fixed-dose combination of losartan/hydrochlorothiazide in patients with uncontrolled hypertension: a multicenter study. ( Akaba, K; Endo, S; Fukui, A; Gomi, H; Hamaguchi, A; Hanaoka, K; Hara, Y; Hasegawa, T; Hayakawa, H; Hayashi, F; Hikida, M; Hirano, K; Horiguchi, M; Hosoya, M; Hosoya, T; Ichida, K; Ikeda, M; Imai, T; Ishii, T; Ishikawa, H; Ishikawa, M; Kameda, C; Kanai, T; Kasai, T; Kawamura, T; Kobayashi, A; Kobayashi, H; Kurashige, M; Kuriyama, S; Kusama, Y; Maezawa, H; Maezawa, Y; Maruyama, Y; Matsuda, H; Matsuo, N; Matsuo, T; Miura, Y; Miyajima, M; Miyakawa, M; Miyazaki, Y; Mizuguchi, M; Morita, T; Nakao, M; Nokano, H; Ogura, M; Ohkido, I; Ohno, I; Ohtsuka, Y; Okada, K; Okamoto, H; Okonogi, H; Saikawa, H; Saito, H; Sekiguchi, C; Soejima, M; Suetsugu, Y; Sugano, N; Suzuki, T; Takahashi, H; Takahashi, Y; Takamizawa, S; Takane, K; Takazoe, K; Tanaka, H; Tanaka, S; Terawaki, H; Tokudome, G; Tomonari, H; Toyoshima, R; Tsuboi, N; Udagawa, T; Ueda, H; Ueda, Y; Uetake, M; Unemura, S; Utsunomiya, M; Utsunomiya, Y; Yamada, T; Yamada, Y; Yamaguchi, Y; Yamamoto, H; Yokoo, T; Yokoyama, K; Yonezawa, H; Yoshida, H; Yoshida, M; Yoshizawa, T, 2012) |
| "Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated." | 3.78 | Genotype-based changes in serum uric acid affect blood pressure. ( Brown, E; Fink, JC; McArdle, PF; Mitchell, BD; Parsa, A; Shuldiner, AR; Weir, MR, 2012) |
| " We assessed performance of base model (model 1: age, sex, BMI, smoking, parental diabetes and hypertension) and two clinical models: model 1 plus fasting glucose (model 2); and model 2 plus uric acid (model 3)." | 3.78 | External validation of the KORA S4/F4 prediction models for the risk of developing type 2 diabetes in older adults: the PREVEND study. ( Abbasi, A; Bakker, SJ; Beulens, JW; Corpeleijn, E; de Jong, PE; Gans, RO; Gansevoort, RT; Hillege, HL; Kowall, B; Meisinger, C; Navis, G; Peelen, LM; Rathmann, W; Stolk, RP, 2012) |
| "Uric acid is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension." | 3.78 | Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999-2006. ( Brady, TM; Fadrowski, JJ; Loeffler, LF; Miller, ER; Navas-Acien, A, 2012) |
| "Several genome-wide association studies (GWASs) have reported associations between single nucleotide polymorphisms (SNPs) and uric acid concentrations or gout in a number of different ethnic populations." | 3.78 | Association between gout and polymorphisms in GCKR in male Han Chinese. ( Chu, N; Han, L; Li, C; Liu, S; Ma, X; Meng, D; Miao, Z; Wang, B; Wang, J; Zhang, K, 2012) |
| " This subanalysis of the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study included 7629 patients, in whom the serum creatinine level was measured at least twice." | 3.78 | Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan. ( Ito, S; Naritomi, H; Ogihara, T; Shimada, K; Shimamoto, K; Tanaka, H; Yoshiike, N, 2012) |
| "Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events." | 3.78 | Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: a Chinese cohort study. ( Bai, CH; Chien, KL; Chou, YC; Chu, CH; Hwang, LC; Su, TC; Sun, CA; Tseng, CH; Yang, T; You, SL, 2012) |
| " Obesity was not associated with differences in composition, although a secondary analysis of morbidly obese patients showed a higher proportion of uric acid stones and a lower proportion of calcium oxalate stones." | 3.78 | Metabolic syndrome and urinary stone composition: what factors matter most? ( Fridirici, ZC; Greco, K; Hart, ST; Kadlec, AO; Turk, TM; Vellos, T, 2012) |
| "The increasing of uric acid level (hyperuricosuria) is regularly detected in blood during the examination of patient with such cardiovascular diseases as arterial hypertension, atherosclerosis, diabetes mellitus, metabolic syndrome and obesity." | 3.78 | [The hyperuricosuria in patients with high content of triglycerides: the combination of genetic and environmental factors and tactics of treatment]. ( Ameliushkina, VA; Iarovaia, EB; Kotkina, TI; Malusheva, PP; Rozhkova, TA; Titov, VN, 2012) |
| "As elevated serum uric acid (SUA) is an independent risk factor for hypertension, we examined whether baseline SUA may influence the blood pressure (BP) response to antihypertensive medications." | 3.78 | Effect of hyperuricemia on the blood pressure response to antihypertensive agents in hospitalized elderly patients. ( Chen, H; Hong, D; Lin, C; Lin, F; Lin, K; Zhu, P, 2012) |
| "Over the past century, uric acid has been considered a possible risk factor for hypertension and cardiovascular disease." | 3.78 | Hyperuricemia and hypertension. ( Feig, DI, 2012) |
| "Individuals with hypertension and hyperuricemia have an increased risk of coronary artery disease and cerebral vascular disease as compared to patients with normal uric acid levels." | 3.77 | A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients. ( Chen, CY; Chen, GY; Huang, CH; Huang, WP; Hung, YJ; Lee, DY; Lin, CS; Tzeng, TF, 2011) |
| "Serum uric acid (UA) plays a key role in the development and progression of hypertension." | 3.77 | Association of serum uric acid level with aortic stiffness and arterial wave reflections in newly diagnosed, never-treated hypertension. ( Aznaouridis, K; Baou, K; Bratsas, A; Dima, I; Lazaros, G; Stefanadis, C; Tzamou, V; Vlachopoulos, C; Vyssoulis, G; Xaplanteris, P, 2011) |
| "Uric acid is an independent predictor of diabetes in primary hypertension." | 3.77 | Serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the MAGIC study. ( Deferrari, G; Leoncini, G; Pontremoli, R; Vercelli, M; Viazzi, F, 2011) |
| "The data regarding the role of serum uric acid (SUA) along with subclinical inflammation in the context of hypertensive vascular damage are rather scarce and controversial." | 3.77 | The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. ( Dimitriadis, K; Katsi, V; Kyvelou, S; Lalos, S; Mihas, C; Poulakis, M; Sideris, S; Skiadas, I; Stefanadi, E; Stefanadis, C; Syrseloudis, D; Tsioufis, C, 2011) |
| "The aim of this study was to examine the independent relationship between serum uric acid (SUA) and blood pressure, and to assess their joint effects on obesity, fasting glucose and lipids." | 3.77 | Interaction between serum uric acid and triglycerides in relation to blood pressure. ( Liang, J; Song, H; Teng, F; Xue, Y; Yang, M; Zhu, R; Zou, C, 2011) |
| "There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management." | 3.77 | Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. ( Bleske, BE; Dorsch, MP; Erickson, SR; Gillespie, BW; Weder, AB, 2011) |
| "Serum uric acid (UA) is positively associated with hypertension (HTN)." | 3.77 | Serum uric acid is associated with high blood pressure in pediatric hemodialysis patients. ( Feig, DI; Goldstein, SL; Mattison, P; Midgley, L; Moudgil, A; Silverstein, DM; Srivaths, PR; Upadhyay, K, 2011) |
| "Trichlormethiazide, a thiazide diuretic, was introduced in 1960 and remains one of the most frequently used diuretics for treating hypertension in Japan." | 3.77 | Adverse effect profile of trichlormethiazide: a retrospective observational study. ( Asai, S; Nakayama, T; Nishida, Y; Takahashi, Y, 2011) |
| "To study the relationship of dyslipidemia and serum uric acid with the risk of myocardial infarction among the hypertensive type 2 diabetic and non-diabetic patients of Trinidad." | 3.77 | Relationship of dyslipidemia and uric acid with the risk of myocardial infarction among hypertensive patients in Trinidad. ( Evernden, K; Fane, U; Fatt, LA; Maharaj, D; Maharaj, N; Maharaj, S; Maharaj, SS; Maharaj, V; Maloney, V; Nayak, BS, 2011) |
| "Our findings suggest the role of low-grade inflammation, uric acid levels, and autonomic dysfunction even in the early stages of hypertension." | 3.77 | Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals. ( Boyacı, B; Cengel, A; Erden, M; Kocaman, SA; Poyraz, F; Sahinarslan, A; Topal, S; Yalçın, MR, 2011) |
| "Because approximately 70% of uric acid is excreted from the kidney, hyperuricemia occurs when renal function deteriorates." | 3.77 | Relationship between hyperuricemia and chronic kidney disease. ( Ohno, I, 2011) |
| " Hyperuricemia was defined as a serum uric acid concentration of at least 420 micromol/l in men and 360 micromol/l in women." | 3.76 | Association of serum uric acid with aortic stiffness and pressure in a Chinese workplace setting. ( Chen, X; Huang, QF; Li, Y; Sheng, CS; Wang, JG; Zheng, Y, 2010) |
| "The results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population." | 3.76 | [Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population]. ( Chang, J; Guo, Y; Li, N; Luo, W; Wang, H; Yan, Z; Yang, J; Zhang, J; Zhou, L, 2010) |
| "Indapamide(1 mg) was given daily for 3 months and was then given every other day for 3 months to patients whose hypertension was poorly controlled with angiotensin II receptor blocker (ARB)-based treatment." | 3.76 | Effects of additional administration of low-dose indapamide on patients with hypertension treated with angiotensin II receptor blocker. ( Kusunose, K; Mishiro, Y; Sata, M; Yamada, H, 2010) |
| "We studied 40 patients with World Health Organization stage I-II essential hypertension, 9 with high serum UA levels (hyperuricemic group) and 31 with normal serum UA levels (normouricemic group, either normouricemics, n = 15, or formerly hyperuricemics in chronic allopurinol treatment, n = 16)." | 3.76 | Serum uric acid levels and renal damage in hyperuricemic hypertensive patients treated with renin-angiotensin system blockers. ( Berardino, S; Berni, A; Boddi, M; Cecioni, I; Chiostri, M; Fattori, EB; Montuschi, F; Poggesi, L, 2010) |
| " The cut-off point varied in subjects with various cardiovascular risk profiles such as serum uric acid level, gender or hypertension." | 3.76 | Very low-grade albuminuria reflects susceptibility to chronic kidney disease in combination with cardiovascular risk factors. ( Ahn, JM; Chae, DW; Chin, HJ; Heo, NJ; Kim, S; Lee, TW; Na, KY, 2010) |
| "We investigated the effects of soluble uric acid (UA) on the development of hypertension in spontaneously hypertensive rats (SHRs), using Wistar-Kyoto rats (WKY) as normotensive controls." | 3.76 | Effect of uric acid on hypertension progression in spontaneously hypertensive rats. ( Chávez, M; Durante, P; Pérez, M; Rivera, F; Romero, F, 2010) |
| " We examined the association between uric acid levels and various clinical parameters, including the components of metabolic syndrome, in essential hypertension." | 3.76 | Association of uric acid with risk factors for chronic kidney disease and metabolic syndrome in patients with essential hypertension. ( Anzawa, R; Fujii, T; Seki, S; Tsutsui, K; Yamazaki, K; Yoshimura, M, 2010) |
| "Uric acid (UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome (MS)." | 3.76 | Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome. ( Chen, XF; Du, YX; Fang, CF; Jiang, JJ; Lin, XF; Pu, ZX; Tang, LJ; Wang, JA, 2010) |
| "Clinical studies have suggested that high levels of uric acid may contribute to the development of hypertension and kidney disease." | 3.76 | High levels of uric acid correlate with decline of glomerular filtration rate in chronic kidney disease. ( Choovichian, P; Duangurai, K; Kanjanakul, I; Nata, N; Phulsuksombuti, D; Satirapoj, B; Supasyndh, O; Utennam, D, 2010) |
| "The aim of the study was to investigate endothelial function in patients with arterial hypertension and impaired uric acid metabolism in comparison with patients having arterial hypertension and normal uric acid metabolism." | 3.76 | [Endothelial function in patients with arterial hypertension and impaired uric acid metabolism]. ( Lebedeva, MV; Minakova, EG; Pulin, AA; Severova, MM; Stakhova, TIu; Zaĭtseva, LI, 2010) |
| "Epidemiologic studies suggest an independent positive association of elevated serum uric acid with essential hypertension." | 3.75 | Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians. ( Chen, T; Dong, B; Lu, Z; Wu, H; Wu, J; Xiao, H; Zhang, Y, 2009) |
| "Higher uric acid levels are associated with an increased risk for developing hypertension." | 3.75 | Fructose and vitamin C intake do not influence risk for developing hypertension. ( Choi, H; Curhan, GC; Forman, JP, 2009) |
| "Uric acid, insulin sensitivity, and endothelial dysfunction may be important in the development of hypertension." | 3.75 | Uric acid and insulin sensitivity and risk of incident hypertension. ( Choi, H; Curhan, GC; Forman, JP, 2009) |
| "The aim of the study was to assess the association of serum uric acid levels with microalbuminuria -urinary albumin excretion (UAE)> or = 30mg/24h-." | 3.75 | Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients. ( Costa, JA; González, C; Miralles, A; Moral, D; Pascual, JM; Pérez-Lahiguera, F; Rodilla, E, 2009) |
| " Each measurement was used as a main predictor in the logistic model where the presence of a metabolic risk factor (high blood pressure, high triglyceride, low high-density lipoprotein cholesterol, high glucose, and high uric acid) was predicted." | 3.75 | Use of waist circumference and ultrasonographic assessment of abdominal fat distribution in predicting metabolic risk factors in healthy Japanese adults. ( Abe, M; Hori, Y; Kimata, A; Kondo, T; Ueyama, J; Yamamoto, K, 2009) |
| "Recent studies suggest that uric acid plays a causal role in the development of hypertension in relation to birth weight." | 3.75 | The association between fetal and postnatal growth status and serum levels of uric acid in children at 3 years of age. ( Cho, S; Cho, SJ; Ha, E; Kang, D; Kim, Y; Lee, H; Min, J; Park, B; Park, E; Park, H, 2009) |
| "Uric acid is heritable and associated with hypertension and insulin resistance." | 3.75 | Genome-wide linkage analysis for uric acid in families enriched for hypertension. ( Asmann, Y; Boerwinkle, E; Fridley, BL; Hunt, SC; Mosley, TH; Pankow, JS; Rule, AD; Turner, ST, 2009) |
| "The Hypertension in the Very Elderly Trial (HYVET) is a randomized double-blind trial of active antihypertensive treatment (indapamide 1." | 3.75 | Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET). ( Banya, W; Beckett, NS; Bulpitt, CJ; Burch, L; Dumitrascu, D; Fletcher, AE; Liu, L; Nikitin, Y; Peters, R; Staessen, JA; Stoyanovsky, V; Wang, JG, 2009) |
| "The aim of this study was to determine urinary excretion of calcium, uric acid and sodium and to evaluate insulin resistance in patients with nephrolithiasis and blood hypertension, isolated and in association, and in healthy controls, in absence of obesity and diabetes." | 3.75 | Patients with nephrolithiasis and blood hypertension have higher calciuria than those with isolated nephrolithiasis or hypertension? ( Casulari, LA; Costa, SS; Reis, MC; Rodrigues, MP; Schleicher, MM, 2009) |
| " We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults." | 3.75 | Serum uric acid and prehypertension among Chinese adults. ( Liang, J; Qi, L; Song, H; Xue, Y; Zhang, T; Zou, C, 2009) |
| "Uric acid (UA) is an emerging cardiovascular (CV) risk factor that is associated with hypertension and CV disease (CVD) in the general population, but whose role in renal transplant recipients (RTR) has not been defined." | 3.75 | Role of uric acid in post-renal transplantation hypertension. ( Bandukwala, F; Huang, M; Prasad, GV, 2009) |
| " Thus, we characterized the antihypertensive effect of the combination of telmisartan and low-dose hydrochlorothiazide in patients with hypertension that was not controlled by amlodipine, which is the most common CCB." | 3.75 | Effect of switching from amlodipine to combination therapy with telmisartan and low-dose hydrochlorothiazide. ( Ando, K; Isshiki, M; Takahashi, K, 2009) |
| " In both sexes, those who developed diabetes were slightly older, were more obese, had a more adverse metabolic profile (higher glucose values, HbA(1c), fasting insulin, uric acid, and triglycerides) and were more likely to have hypertension at baseline than were participants remaining free of diabetes (P < 0." | 3.75 | Incidence of Type 2 diabetes in the elderly German population and the effect of clinical and lifestyle risk factors: KORA S4/F4 cohort study. ( Giani, G; Heier, M; Holle, R; Meisinger, C; Rathmann, W; Strassburger, K; Thorand, B, 2009) |
| " Fructose induced an increase in serum uric acid after 8-10 weeks of increased fructose exposure, but no correlation was found between hyperuricemia and hypertension." | 3.74 | Does an apple a day put hypertension in play? ( Günthner, T; Jankowski, J, 2008) |
| "In rats with hyperuricemia induced by 2% oxonic acid and 0." | 3.74 | Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia. ( Chen, K; Cui, WY; Liu, GS; Long, CL; Pan, ZY; Qin, XC; Wang, H; Zhang, YF, 2008) |
| "Several studies have found that uric acid (UA) level is associated with an increased risk for hypertension, but the association could be confounded by metabolic factors that were not included in these previous studies." | 3.74 | Plasma uric acid level and risk for incident hypertension among men. ( Choi, H; Curhan, GC; Forman, JP, 2007) |
| "The aim of this project was to study the risk of developing hypertension over a 6-year follow-up in normotensive men with baseline hyperuricemia (serum uric acid >7." | 3.74 | Hyperuricemia and incidence of hypertension among men without metabolic syndrome. ( Krishnan, E; Kuller, L; Kwoh, CK; Schumacher, HR, 2007) |
| "Experimental evidence supports a causal role of serum uric acid in hypertension development." | 3.74 | Association between serum uric acid and prehypertension among US adults. ( Li, J; Shankar, A; Syamala, S, 2007) |
| "The aim of this study was to examine whether serum uric acid (SUA) concentration was related to the metabolic syndrome (MS)." | 3.74 | Serum uric acid is significantly related to the components of the metabolic syndrome in Japanese workingmen. ( Katsumata, M; Kawada, T; Otsuka, T; Suzuki, H, 2007) |
| " Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance." | 3.74 | Thiazide diuretics exacerbate fructose-induced metabolic syndrome. ( Johnson, RJ; Mu, W; Nakagawa, T; Reungjui, S; Roncal, CA; Sirivongs, D; Srinivas, TR, 2007) |
| "The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation." | 3.74 | Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. ( Baumert, J; Döring, A; Koenig, W; Meisinger, C, 2008) |
| "The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study is a nationwide, prospective, multicentered, observational study that was designed to enroll 30,000 hypertensive Japanese patients from more than 3,000 private practitioners." | 3.74 | Efficacy and safety of long-term losartan therapy demonstrated by a prospective observational study in Japanese patients with hypertension: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study. ( Fujita, T; Ito, S; Naritomi, H; Ogihara, T; Shimada, K; Shimamoto, K; Tanaka, H; Yoshiike, N, 2008) |
| "Serum uric acid (UA) has been implicated in the pathogenesis of hypertension." | 3.73 | Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. ( D'Agostino, RB; Kannel, WB; Levy, D; Sullivan, L; Sundström, J; Vasan, RS, 2005) |
| "Uric acid has been proposed as an important risk factor in the development of primary hypertension in humans." | 3.73 | Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. ( Alper, AB; Berenson, GS; Chen, W; Hamm, LL; Srinivasan, SR; Yau, L, 2005) |
| "Serum uric acid levels, plasma protein C (PC), protein S (PS), antithrombin III (AT III) activities and activated protein C resistance (APCR) were measured in 80 pregnant women with hypertension (preeclampsia, n = 32; severe preeclampsia, n = 25; eclampsia, n = 14; chronic hypertension, n = 9) and 58 healthy pregnant women." | 3.73 | Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy. ( Sayin, M; Sayin, NC; Varol, FG, 2005) |
| "The levels of the liporegulatory hormone leptin are increased in obesity, which contributes to the metabolic syndrome; the latter is associated with elevated cardiovascular risk and morbidity." | 3.73 | Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans. ( Chraibi, A; Israili, ZH; Lyoussi, B; Mguil, M; Ragala, MA, 2005) |
| "To investigate if increased lipid peroxidation is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions." | 3.73 | Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats. ( Atarashi, K; Ishiyama, A; Minami, M; Omata, M; Takagi, M, 2005) |
| " The present study examined a Korean adult population with respect to the relationships between serum uric acid concentrations and hypertension, insulin resistance, and the risk factors of metabolic syndrome." | 3.73 | Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. ( Kang, JH; Keum, DG; Kim, BJ; Kim, BS; Kim, H; Kim, SW; Lee, MH; Lee, WY; Park, JR; Rhee, EJ; Ryu, SH; Shin, HS; Sung, KC; Yoo, TW, 2005) |
| "Apocynin but not allopurinol prevented and reversed ACTH-induced hypertension in the rat." | 3.73 | Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat. ( Andrews, MC; Chan, MM; Croft, KD; McKenzie, KU; Mori, TA; Schyvens, CG; Whitworth, JA; Zhang, Y, 2005) |
| "Uric acid (UA) may play a pathogenetic role in hypertension and kidney disease." | 3.73 | Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients? ( Armstrong, KA; Campbell, SB; Hawley, CM; Isbel, NM; Johnson, DW, 2005) |
| "The association between serum uric acid (UA) and the prevalence of hypertension, and the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphism and hypertension remains unclear." | 3.73 | Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men. ( Date, C; Lwin, H; Saito, K; Tanaka, H; Yamamoto, A; Yokoyama, T; Yoshiike, N, 2006) |
| "Elevated serum uric acid (UA) is frequently encountered in individuals with hypertension, but whether the relationship between UA and cardiovascular events is circumstantial or causal remains to be answered." | 3.73 | Uric acid, left ventricular mass index, and risk of cardiovascular disease in essential hypertension. ( Horio, T; Iwashima, Y; Kamide, K; Kawano, Y; Ogihara, T; Rakugi, H, 2006) |
| " Serum uric acid and higher birth weight are predictors of LVM." | 3.73 | Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension. ( Antoniewicz, J; Daszkowska, J; Grenda, R; Litwin, M; Niemirska, A; Sladowska, J; Wawer, ZT; Wierzbicka, A, 2006) |
| "The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke." | 3.73 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. ( Bos, MJ; Breteler, MM; Hofman, A; Koudstaal, PJ; Witteman, JC, 2006) |
| " Endothelial dysfunction and high levels of serum uric acid are associated with hypertension." | 3.73 | Effects of low birth weight in 8- to 13-year-old children: implications in endothelial function and uric acid levels. ( Ajzen, SA; Christofalo, DM; Franco, MC; Sawaya, AL; Sesso, R, 2006) |
| "The aim of the present study was to determine whether sex differences contribute to the association of serum uric acid and left ventricular hypertrophy in individuals with hypertension." | 3.73 | Gender-related association of serum uric acid and left ventricular hypertrophy in hypertension. ( Fujii, K; Iida, M; Matsumura, K; Ohtsubo, T; Oniki, H, 2006) |
| "To study effects of uric acid disbolism in combination with other metabolic disturbances on prevalence and clinical symptoms of arterial hypertension; contribution of uric acid nephropathy to its development." | 3.73 | [Relationships between arterial hypertension, metabolic disturbances and uric acid nephropathy]. ( Balkarov, IM; Britov, AN; Deev, AD; Eliseeva, NA, 2006) |
| "Increasing experimental evidence, including recently developed animal models support a causal role for uric acid in the development of hypertension." | 3.73 | The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study. ( Klein, BE; Klein, R; Nieto, FJ; Shankar, A, 2006) |
| "Serum uric acid has been positively associated with incident hypertension, but previous studies have had limited ability to explore this relationship across sex and ethnic strata." | 3.73 | Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. ( Bleyer, AJ; Erlinger, TP; Evans, GW; Herrington, DM; Mellen, PB; Nieto, FJ; Wagenknecht, LE; Wofford, MR, 2006) |
| "Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension." | 3.73 | Uric acid and the development of hypertension: the normative aging study. ( Gaziano, M; Gumieniak, O; Litonjua, AA; Perlstein, TS; Sparrow, D; Vokonas, PS; Weiss, ST; Williams, GH, 2006) |
| "Uric acid and oxidative stress promote cardiovascular diseases, including atherosclerosis and hypertension." | 3.73 | Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats. ( Hamada, T; Hisatome, I; Igawa, G; Igawa, O; Kaetsu, Y; Matsubara, K; Matsuura, T; Miake, J; Ogino, K; Shigemasa, C; Sugihara, S; Yamamoto, T; Yamamoto, Y; Yoshida, A, 2006) |
| "Uric acid is frequently elevated in hypertension." | 3.72 | Serum uric acid in hypertensive patients with and without peripheral arterial disease. ( Blaton, V; De Bacquer, D; De Buyzere, M; Delanghe, J; Duprez, D; Langlois, M, 2003) |
| "Experimental animal models suggest that uric acid might have a pathogenic role in the early development of primary hypertension." | 3.72 | Hyperuricemia in childhood primary hypertension. ( Feig, DI; Johnson, RJ, 2003) |
| "We examined the association of serum uric acid (SUA) with development of hypertension (blood pressure > or = 140/90 mmHg and/or medication for hypertension) and impaired fasting glucose (IFG) (a fasting plasma glucose level 6." | 3.72 | Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. ( Matsuo, Y; Nakanishi, N; Okamoto, M; Suzuki, K; Tatara, K; Yoshida, H, 2003) |
| " Univariate analysis revealed statistical significance for the following variables associated with eclampsia: systolic hypertension > or =160 mmHg and diastolic > or =110 mmHg, headache, visual symptoms, vivid deep tendon reflexes, proteinuria >3+ or >3 g d(-1), uric acid concentration > or =350 micromol l(-1), serum creatinine concentration >100 micromol l(-1) and aminotransferase aspartate >30 IU l(-1)." | 3.72 | [Risk factors for eclampsia: a case-control study]. ( Arfaoui, C; Ben Salem, F; Ben Salem, K; Faleh, R; Gahbiche, M; Grati, L; Guerdelly, I; Jmel, A, 2003) |
| " The objective of the present study was determination of incidence of selected risk factors of IHD, such as overweight and obesity, tobacco smoking, arterial hypertension, type 2 diabetes mellitus, dyslipidaemia, and elevated serum concentration of uric acid." | 3.72 | Selected risk factors of ischemic heart disease in Polish seafarers. Preliminary report. ( Filikowski, J; Renke, W; Rzepiak, M; Smolińska, D; Winnicka, A, 2003) |
| "The aim of the present study was to determine the change of serum uric acid (UA) levels in male adolescents and to characterize the relationship between UA levels and obesity or its related factors." | 3.72 | Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002. ( Kishida, M; Matsumoto, Y; Matsuura, K; Mimura, Y; Ogura, T; Otsuka, F; Tobe, K, 2004) |
| "A 7-year followup study among men with hyperuricemia was conducted to study the longterm relationships between serum uric acid concentrations and cardiovascular diseases." | 3.72 | Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia. ( Chen, CH; Chou, P; Lin, KC; Tsao, HM, 2004) |
| "We have examined whether hyperuricemia in essential hypertension may be related to an increased insulin secretion thereby enhancing the tubular reabsorption of sodium and thus uric acid." | 3.72 | The pathophysiology of hyperuricemia in essential hypertension: a pilot study. ( Bernardino, JI; Campo, C; Grande, C; Puig, JG; Ruilope, LM; Sancho, T; Torres, RJ, 2004) |
| "Blood levels of uric acid, cholesterol, triglycerides (TG), high and low density lipoproteins were examined and glucose tolerance test was made in 108 adolescents with arterial hypertension (AH) and different physical constitution (normal, with overweight and obese)." | 3.72 | [Arterial hypertension in adolescents with different physical constitution including those with signs of metabolic syndrome]. ( Kazakova, LM; Rovda, EIu; Rovda, IuI; Rovda, TS, 2004) |
| "Body weight and BP decreased significantly in the diet group but not in the troglitazone group at the end of the intervention periods." | 3.71 | Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. ( Kamide, K; Kawano, Y; Minami, J; Tsunoda, S, 2002) |
| " When the cluster of metabolic syndrome was analyzed, SG was inversely related to uric acid levels and to the waist-hip index." | 3.71 | [Glucose effectiveness and components of the metabolic syndrome in recently diagnosed hypertensive patients]. ( Carneado de la Fuente, J; García Morillo, JS; García-Junco, PS; Miranda Guisado, ML; Muñiz Grigalvo, O; Pamies Andreu, E; Vallejo Maroto, I; Villar Ortiz, J, 2002) |
| " The modification of deltaHX by angiotensin-converting enzyme inhibitors and alpha1-blockers influenced the level of serum uric acid, suggesting that the skeletal muscles may be an important source of uric acid as well as of the substrate of xanthine oxidase in hypertension." | 3.71 | The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers. ( Furuse, M; Furuse, Y; Hamada, T; Hisatome, I; Igawa, O; Katoh, M; Kinugawa, T; Murakami, F; Ogino, K; Ohtahara, A; Shigemasa, C; Shimomura, T; Sonoyama, K; Watanabe, M; Yamamoto, T; Yamamoto, Y, 2001) |
| "To investigate the association of serum uric acid level with the risk for hypertension and Type 2 diabetes." | 3.71 | Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey. ( Endo, G; Fujii, S; Hayashi, T; Okada, K; Taniguchi, Y; Tsumura, K, 2001) |
| "To analyse relationships between left ventricular myocardium mass (LVMM) and imbalance of uric acid metabolism in patients with arterial hypertension (AH)." | 3.71 | [Relationship between mass of the left ventricular myocardium and uric acid metabolic imbalance in patients with arterial hypertension]. ( Anikina, SA; Balkarov, IM; Donskov, AS; Feofanova, ID; Golub', GV; Prilepo, NA; Saltykova, NG; Sviderskaia, NS, 2001) |
| "Our objective was to determine whether two methylxanthines, pentoxifylline (PTX) and allopurinol, would have beneficial effects on experimental pregnancy-induced pre-eclampsia- like disease in ewes." | 3.71 | Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes. ( Németh, I; Pintér, S; Tálosi, G, 2001) |
| "Our data suggest that there is a strong, independent association between familial occurrence of hypertension and the phenotype characterized by combined elevation of both urinary uric acid and calcium excretions." | 3.71 | High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension. ( Bull, SB; Honey, JD; Logan, AG; Pierratos, A; Rosivall, L; Tisler, A, 2002) |
| "The aim of our study was to estimate the serum levels of glucose, insulin, C-peptide and uric acid in patients with psoriasis before and after treatment." | 3.71 | [Evaluation of glucose, insulin, C-peptide uric acid serum levels in patients with psoriasis]. ( Fafara, I; Grzybowski, G; Wierusz-Wysocka, B; Zaba, R, 2001) |
| "Our purpose was to evaluate the clinical utility of serum uric acid measurements in the hypertensive diseases of pregnancy." | 3.70 | The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. ( Ecker, JL; Friedman, SA; Kao, L; Kilpatrick, SJ; Lim, KH, 1998) |
| "An elevated red blood cell (RBC) sodium-lithium countertransport (Na-Li CT) is associated with high blood pressure (BP) in cross-sectional investigations; however, its value as a predictor of future hypertension, and thus of cardiovascular risk, has not been defined." | 3.70 | Red blood cell sodium-lithium countertransport and risk of future hypertension: the Olivetti Prospective Heart Study. ( Cappuccio, FP; Farinaro, E; Iacone, R; Ragone, E; Russo, L; Siani, A; Strazzullo, P; Trevisan, M, 1998) |
| " The serum leptin concentration, body mass index (BMI), percent body fat, total fat mass (FM), waist and hip circumference, waist to hip ratio (WHR), prevalence of hypertension, and triglyceride (TG), lipoprotein, and uric acid concentration were determined in 86 type 2 diabetic (n = 59) and healthy (n = 27) subjects." | 3.70 | Serum leptin is associated with serum uric acid concentrations in humans. ( Beyer, J; Fruehwald-Schultes, B; Kern, W; Peters, A; Pfützner, A, 1999) |
| " Some studies have reported substantial weight loss, signs of dehydration, raised serum concentrations of uric acid and cholesterol, etc." | 3.70 | [Effects of Ramadan fasting on the health of Muslims]. ( Morimoto, K; Toda, M, 2000) |
| " In 273 Type 2 diabetics, serum uric acid was analysed against basic demographic data (age, sex, smoking and alcohol habits, body mass index, number of years since the diagnosis of diabetes), present medications, control of diabetic state (attending physician's estimation of the patient's diet compliance, fasting serum sugar, HbA1c), and complications (serum creatinine, total cholesterol, triglyceride, urine proteinuria, retinopathy, last blood pressure readings, history of hypertension, coronary heart disease, stroke)." | 3.70 | Hyperuricaemia in Type 2 diabetes mellitus. ( Chan, CS; Lui, CS; Wun, YT, 1999) |
| "To investigate the incidence of gout and the interaction between uric acid level and other risk factors in the development of gout." | 3.70 | The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. ( Chou, P; Lin, HY; Lin, KC, 2000) |
| "Our purpose was to evaluate the clinical utility of serum uric acid measurements in the hypertension diseases of pregnancy." | 3.70 | The clinical utility of serum uric acid measurements in pre-eclampsia and transient hypertension in pregnancy. ( Baviera, G; D'Anna, R; Leo, R; Leonardi, I; Scilipoti, A, 2000) |
| "The question of serum uric acid as an independent risk factor in subjects with essential hypertension remains controversial." | 3.70 | Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. ( Brunetti, P; Porcellati, C; Reboldi, G; Santeusanio, F; Schillaci, G; Verdecchia, P, 2000) |
| "Cyclosporine for microemulsion has been widely used in the treatment of rheumatoid arthritis (RA) with remarkably good results over progression of joint damage, as reported by the GRISAR Study." | 3.70 | [Efficacy, tolerability and safety of cyclosporine for microemulsion in the treatment of active rheumatoid arthritis. Open study]. ( Battagliotti, C; Díaz, EA; Garsd, A; Grosman, H; Gutfraind, E; Maccagno, A; Maldonado Cocco, J; Marcos, JC; Messina, DO; Onetti, CM; Otero, AB; Tate, G; Venarotti, HO, 2000) |
| " It has been proposed that the elevated serum uric acid levels are linked to other risk factors, such as hypertension, dyslipidaemia and diabetes." | 3.70 | Management of hypertension and dyslipidaemia in patients presenting with hyperuricaemia: case histories. ( Elisaf, MS; Milionis, HJ, 2000) |
| " Patients within the lowest C-peptide quartile showed significantly higher duration of diabetes, prevalence of retinopathy and values of HDL-cholesterol, albumin excretion rate and HbA1c, while BMI, diastolic blood pressure, percentages of hypertension and metabolic syndrome, and values of triglycerides and uric acid were significantly higher in the highest C-peptide quartile." | 3.70 | Relationship of residual beta-cell function, metabolic control and chronic complications in type 2 diabetes mellitus. ( Bo, S; Cavallo-Perin, P; Gentile, L; Pagano, G; Repetti, E, 2000) |
| "The association between serum uric acid and hypertension was evaluated in a sample of male workers in southern Italy enrolled in the Olivetti Heart Study, an ongoing longitudinal epidemiological investigation on risk factors for coronary heart disease carried out at the Olivetti factory in the suburban area of Naples." | 3.69 | Serum uric acid and hypertension: the Olivetti heart study. ( Celentano, E; Farinaro, E; Galasso, R; Jossa, F; Krogh, V; Mancini, M; Panico, S; Trevisan, M, 1994) |
| "Serum concentrations of insulin, uric acid, total and lipoprotein cholesterol, triglyceride, and apolipoproteins A-I and B were measured in 31 women with pregnancy-induced hypertension (eight with proteinuria) and in 21 healthy, pregnant, weight-matched controls at 30-39 weeks' gestation." | 3.69 | Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women. ( Kaaja, R; Tikkanen, MJ; Viinikka, L; Ylikorkala, O, 1995) |
| "Behavioural and biological correlates of serum uric acid were investigated in 2487 men who received a retirement health examination at the Self-Defence Forces Fukuoka Hospital from October 1986 through 1990, excluding those under medication for hyperuricaemia, hypertension or hyperlipidaemia." | 3.69 | Behavioural and biological correlates of serum uric acid: a study of self-defence officials in Japan. ( Honjo, S; Imanishi, K; Kono, S; Shinchi, K; Todoroki, I, 1994) |
| " The biopsy findings of the placental bed were compared with adequate weight at birth related to gestational age, and to the following clinical parameters of the mother: arterial blood pressure, serum creatinine, serum uric acid and proteinuria." | 3.69 | Placental bed lesions and infant birth weight in hypertensive pregnant women. ( Costa, CA; Edelweiss, MI; Martins-Costa, S; Ramos, JG, 1995) |
| "In a group of 80 women in their 3rd trimester of pregnancy (29-36 weeks) 50 of whom were with hypertension and 30 healthy, the blood serum was studied for concentrations of urea, uric acid, creatinine, total proteins and electrolytes: sodium and potassium." | 3.69 | [Kidney function in pregnant women with arterial hypertension]. ( Banaczek, Z, 1995) |
| "The present study aimed to assess the influence of a highly industrialized environment on the prevalence of arterial hypertension and plasma levels of cholesterol, uric acid, aldosterone and plasma renin activity." | 3.69 | Does industrial environment influence the prevalence of arterial hypertension, plasma cholesterol and uric acid concentration and activity of the renin-aldosterone system? ( Kokot, F; Wiecek, A, 1996) |
| "To determine the usefulness of platelet count, mean platelet volume and serum uric acid levels in the prediction of pre-eclampsia in women with mild hypertension in pregnancy, and to see if it is appropriate to base the management of such patients on these tests." | 3.69 | Poor predictive value of platelet count, mean platelet volume and serum urate in hypertension in pregnancy. ( Calvert, SM; Haley, J; Tuffnell, DJ, 1996) |
| " Urinary excretion rates of calcium, sodium, chloride, potassium, urinary calcium/creatinine index, the fractional excretion of sodium, potassium and uric acid, the creatinine clearance and serum values of creatinine, urea, uric acid, electrolytes, total proteins, parathormone (intact molecule), plasma renin activity, aldosterone, glucose, and insulin (fasting and after an oral glucose load) were performed in every patient and control subject." | 3.69 | Urinary calcium excretion in treated and untreated essential hypertension. ( Navarro-Antolin, J; Orte, L; Ortuño, J; Quereda, C; Sabater, J; Villafruela, JJ, 1996) |
| "Systolic blood pressure, diastolic blood pressure, serum cholesterol, serum uric acid, past history of illness, present illness, body mass index (BMI: weight/height2 (kg/m2)), indices of weight change (the intrapersonal standard deviation of BMI (ISD), the coefficient of variation of BMI (CV), the root mean square error of variation (RMSE) around the slope of BMI vs age, weight change categories (cycler, weight gainer, no changer, etc." | 3.69 | An evaluation of various indices of body weight change and their relationship with coronary risk factors. ( Horie, S; Itoh, T; Okubo, T; Takahashi, K, 1996) |
| "Serum uric acid estimation was done in forty primigravidae with pregnancy induced hypertension and twenty normotensive primigravida in the third trimester of pregnancy, at delivery and six weeks postpartum." | 3.69 | Hyperuricemia and pregnancy induced hypertension--reappraisal. ( Dhaliwal, L; Gopalan, S; Mustaphi, R; Sarkar, AK, 1996) |
| "To evaluate the variations and potential clinical use of serial maternal alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) in pregnancies at risk of pregnancy-induced hypertension (PIH) and/or intrauterine growth retardation (IUGR), we investigated the relationship between placental sonographic findings, uterine artery Doppler measurements, and maternal serum AFP, hCG, and uric acid levels between 20 and 34 weeks of pregnancy." | 3.69 | Maternal serum testing for alpha-fetoprotein and human chorionic gonadotropin in high-risk pregnancies. ( Campbell, S; Gulbis, B; Jauniaux, E; Meuris, S; Ramsay, B; Tunkel, S, 1996) |
| "Stroke was significantly associated with hypertension and high values of plasma glucose but not with fibrinogen, factor VIIc, or factor VIIIc." | 3.69 | Associations between carotid atherosclerosis and high factor VIII activity, dyslipidemia, and hypertension. ( Bai, CH; Chen, JR; Chiu, HC; Pan, WH, 1997) |
| "The objective was to analyse the levels of uric acid in the hypertensive disorders of pregnancy." | 3.69 | [Variations in the uric acid levels in pregnancy hypertension]. ( Rojas-Ruiz, A; San Martín-Herrasti, JM; Vital-Terán, L, 1997) |
| "8 yrs old, with untreated mild essential hypertension, serum uric acid, total cholesterol triglycerides and glucose were examined at 8 a." | 3.69 | [Serum levels of uric acid, lipids and glucose in essential hypertension]. ( Bogdanovska, S; Lozance, Lj; Masin-Paneva, J; Zafirovska, K, 1996) |
| "The aim of the present study was to evaluate the relationship of C-peptide and the C-peptide/bloodsugar ratio with clinical/biochemical variables presenting a well-known association with insulin resistance in NIDDM patients in acceptable control, obtained without the use of exogenous insulin." | 3.69 | Relationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients. ( Acosta, D; Astorga, R; García de Pesquera, F; Losada, F; Morales, F; Pumar, A; Relimpio, F, 1997) |
| " 51Chromium-ethylenediamine tetraacetic acid, para-amino hippuric acid, lithium, and sodium clearances, measurements of serum and urinary electrolytes, and urinary concentration tests were performed." | 3.69 | Kidney function in cyclosporine-treated pediatric heart transplant recipients. ( Holmberg, C; Jalanko, H; Laine, J; Leijala, M; Sairanen, H, 1997) |
| "Blood pressures of 122 patients, undergoing alcohol withdrawal treatment in hospital, were taken at admission and one and two weeks after admission, and various laboratory tests that are thought to be the markers of alcoholism (gamma glutamyltransferase--GGT, mean corpuscular volume--MCV, serum uric acid) were performed (by the authors)." | 3.68 | Hypertension and alcoholism. ( Kondorosi, G; Morvai, V; Szépvölgyi, E; Ungváry, G, 1993) |
| "Serum uric acid and oxypurines (hypoxanthine and xanthine) renal excretion of uric acid and oxypurines as well as plasma adenosine deaminase activity and AMP deaminase activity were studied in 18 patients with essential hypertension and in 17 healthy subjects." | 3.68 | [Value of oxypurines and uric acid in plasma, renal excretion of oxypurines and uric acid as well as plasma adenosine deaminase and AMP deaminase activity in patients with essential hypertension]. ( Banaszak, F; Głuszek, J; Tykarski, A, 1993) |
| "In order to know if abnormalities of calcium metabolism may be involved in the pathophysiology of pregnancy-induced hypertension (PIH), as it has been incriminated in essential hypertension, we measured plasma and urinary calcium and phosphate as well as plasma PTH and free calcitriol index (ratio of total calcitriol on the D binding protein) in normotensive pregnant women (n = 25), in women with PIH after the same duration of amenorrhea (> 28 wk, n = 21:preeclampsia and 20 transient hypertensions), and in age-matched nonpregnant women (n = 15)." | 3.68 | Calcium metabolism, plasma parathyroid hormone, and calcitriol in transient hypertension of pregnancy. ( Bouillon, R; el Esper, N; Fournier, A; Jans, I; Lalau, JD, 1993) |
| "Long-term efficacy and safety of the beta1-selective adrenoceptor-blocking agent bisoprolol was investigated in 164 patients with mild to moderate essential hypertension who had already been treated successfully with bisoprolol once daily for 1 year in preceding studies." | 3.68 | Three years of experience with bisoprolol in the treatment of mild to moderate hypertension. ( Buchner-Möll, D; Giesecke, HG, 1990) |
| "Serial estimations of platelet angiotensin II binding were made in two patients with hypertension developing in the third trimester of pregnancy." | 3.68 | Serial measurements of platelet angiotensin II binding in two patients with hypertension in pregnancy: case reports. ( Baker, PN; Broughton Pipkin, F, 1992) |
| "In patients with healthy native kidneys, long-term cyclosporine therapy, even at a low dose (5 mg/kg per day), is nephrotoxic and is associated with a high incidence of hypertension." | 3.68 | Renal function and blood pressure in patients receiving long-term, low-dose cyclosporine therapy for idiopathic autoimmune uveitis. ( Aupetit, B; Baumelou, A; Benhmida, M; Deray, G; Jacobs, C; Le Hoang, P; Maksud, P, 1992) |
| "This study was conducted to elucidate renal uric acid metabolism in patients with primary aldosteronism (PA;16 cases) as compared with normotensive subjects (NT;25 cases) and essential hypertensives (EHT;51 cases)." | 3.68 | [Study on uric acid metabolism in patients with primary aldosteronism]. ( Iimura, O; Kikuchi, K; Komura, H; Marusaki, S; Namba, M; Ohtomo, T; Satoh, N; Suzuki, S; Takada, T, 1992) |
| " To evaluate proximal tubular resorption and its relationship with erythrocyte cation transport systems that are known to be abnormal in essential hypertension, we measured fractional excretion of endogenous uric acid (FE Ur%) and exogenous lithium (FE Li%), erythrocyte sodium concentration, Na-K pump, Na-K cotransport and Li-Na countertransport in two groups of kidney transplant recipients with normal kidney function (creatinine less than 1." | 3.68 | Mechanisms of cyclosporine-induced hypertension. ( Barlassina, C; Bianchi, G; Cusi, D; Elli, A; Niutta, E; Quarto di Palo, F, 1991) |
| "The present study aimed to elucidate the role of renal dopaminergic and prostaglandin (PG) systems in renal uric acid metabolism in essential hypertension." | 3.68 | [The role of the renal dopaminergic and the prostaglandin systems in renal uric acid metabolism in patients with essential hypertension]. ( Hasegawa, T; Iimura, O; Kikuchi, K; Komura, H; Marusaki, S; Nanba, M; Ohtomo, T; Satoh, N; Suzuki, S; Takada, T, 1991) |
| "In forty patients with mild to moderate essential hypertension and in twenty healthy subjects serum uric acid was measured and parameters of renal excretion of urate were evaluated." | 3.68 | [Uric acid and arterial hypertension. I. Relation between serum uric acid level and its renal excretion in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "In forty patients with mild to moderate essential hypertension correlation between serum uric acid as well as renal excretion of urate and the transport of uric acid in nephron was evaluated." | 3.68 | [Uric acid and arterial hypertension. II. Evaluation of uric acid transport in the nephrons in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "In sixteen patients with moderate essential hypertension the effects of 10-day nifedipine treatment on serum uric acid and renal excretion of uric acid were evaluated." | 3.68 | [Uric acid and arterial hypertension. III. Effect of nifedipine on serum uric acid level and its renal excretion in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "Plasma values of atrial natriuretic factor (ANF) were evaluated in 31 women with pregnancy-induced hypertension (PIH) and 31 normal pregnant women at the same age of gestation." | 3.68 | Plasma concentrations of atrial natriuretic factor and hemodynamics in pregnancy-induced hypertension. ( Ambrosioni, E; Borghi, C; Boschi, S; Cassani, A; Contarini, A; Crippa, S; Marlettini, MG; Morselli-Labate, AM; Orlandi, C; Ricci, C, 1991) |
| "In forty patients with essential hypertension correlation between serum uric acid and some clinical features of hypertensive disease i." | 3.68 | [Uric acid and arterial hypertension. IV. Relation between serum uric acid level, the extent of vascular changes and heart enlargement in primary arterial hypertension]. ( Oko-Sarnowska, Z; Skołuda, A; Tykarski, A, 1991) |
| "We reviewed the clinical features and uric acid metabolism in 37 female patients with gout." | 3.68 | Female gout. Clinical spectrum and uric acid metabolism. ( Capitán, CF; de Miguel, E; Gijón, JB; Jiménez, ML; Mateos, FA; Michán, AD; Pérez de Ayala, C; Puig, JG, 1991) |
| "The authors examined the plasma renin activity (PRA), serum uric acid and creatinine in 53 patients with essential hypertension (EH)." | 3.68 | [Plasma renin activity, creatinine and uric acid in the serum of patients with essential hypertension]. ( Mechír, J; Pjescák, M; Rajnová, E; Suchmanová, I; Tkácová, R, 1990) |
| "We carried out a study of 43 male asymptomatic subjects with high levels of uric acid but showing no signs of arterial hypertension, obesity or alcohol abuse." | 3.68 | Hyperuricemia-hyperlipemia association in the absence of obesity and alcohol abuse. ( Añon Barbudo, J; Collantes Estevez, E; Pineda Priego, M; Sanchez Guijo, P, 1990) |
| "Treatment of hypertension with diuretics and beta-blockers is often associated with changes in lipids and uric acid levels." | 3.67 | The impact on serum lipids of combinations of diuretics and beta-blockers and of beta-blockers alone. ( Helgeland, A, 1984) |
| "The effect of verapamil on different metabolic parameters has been studied after changing the treatment of hypertension from hydrochlorothiazide to verapamil monotherapy." | 3.67 | Metabolic parameters after changing from hydrochlorothiazide to verapamil treatment in hypertension. ( Gordin, A; Lehtonen, A, 1984) |
| "In order to evaluate both the hypotensive and uric acid-retaining effects of thiazide diuretics in an animal model with hypertension, the effects of trichlormethiazide were studied using spontaneously hypertensive rats (SHR) under dietary sodium restriction." | 3.67 | Hypotensive and uric acid-retaining effects of trichlormethiazide under dietary sodium restriction in spontaneously hypertensive rats. ( Ishii, M; Iwaki, K; Yonetani, Y, 1984) |
| " Abnormal angiograms were associated with greater age, treated hypertension, current smoking, and lower hemoglobin levels but with higher uric acid, factor VIII, and fibrinogen concentrations." | 3.67 | Arterial disease risk factors and angiographic evidence of atheroma of the carotid artery. ( Harrison, MJ; Hurst, C; Meade, TW; Schneidau, A; Wilkes, HC, 1989) |
| " Parameters measured included blood pressure, blood chemistry (serum creatinine, uric acid, blood urea nitrogen, blood glucose total cholesterol, and electrolytes), plasma renin activity, and plasma aldosterone concentration." | 3.67 | Effects of nicardipine on blood pressure and renal function in elderly hypertensive patients with renal dysfunction. ( Saruta, T, 1989) |
| "Changes in serum lipids, apolipoproteins, and lipoproteins including high-density lipoprotein (HDL) subfractions following administration of captopril in patients with hypertension were studied." | 3.67 | Effect of captopril on high-density lipoprotein subfractions in patients with mild to moderate essential hypertension. ( Arakawa, K; Sasaki, J, 1989) |
| "Maximum serum uric acid (SUA) levels during the third trimester of pregnancy were selected in 215 hypertensive pregnant women: 100 with mild preeclampsia (PE), 25 with severe PE, 70 with essential hypertension (EH) and 20 with EH with superimposed PE (EH + PE)." | 3.67 | Uric acid levels: a useful index of the severity of preeclampsia and perinatal prognosis. ( Darbon-Grosso, HA; Illia, R; Imaz, FU; Margulies, M; Voto, LS, 1988) |
| "The influence of a family history of hypertension on body mass index, serum lipids, uric acid, blood sugar and haematocrit was investigated in 579 young normotensives aged 19-35 years with or without a parental history of hypertension." | 3.67 | Clinical alterations in normotensive offspring with parental hypertension. ( Fujishima, M; Takishita, S; Tomita, Y; Tsuchihashi, T; Ueno, M, 1988) |
| "The long-term efficacy and tolerance of spironolactone in essential hypertension was evaluated among 20,812 patients referred to the Broussais and St." | 3.67 | Efficacy and tolerance of spironolactone in essential hypertension. ( Charru, A; Chatellier, G; Corvol, P; DeVries, C; Jeunemaitre, X; Kreft-Jais, C; Menard, J; Plouin, PF, 1987) |
| "Interaction of thiazide diuretics and the serum uric acid and creatinine levels was studied in 3693 stepped care participants in the Hypertension Detection and Follow-up Program not receiving treatment at baseline." | 3.67 | Is thiazide-produced uric acid elevation harmful? Analysis of data from the Hypertension Detection and Follow-up Program. ( Blaufox, MD; Borhani, NO; Curb, JD; Langford, HG; Molteni, A; Pressel, S; Schneider, KA, 1987) |
| "Plasma renin activity (PRA), plasma aldosterone (PA), blood uric acid (BUA), plasma concentrations of catecholamines (Pcat) and plasma volume (PV) were measured simultaneously in 24 patients with pregnancy-induced hypertension." | 3.67 | Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension. ( Boulanger, JC; Carayon, A; Coevoet, B; Comoy, E; de Fremont, JF; Demory, JE; Desailly, I; Fievet, P; Pleskov, L; Verhoest, P, 1985) |
| "A single-blind study was carried out in 22 out-patients with mild to moderate hypertension to investigate the effects of piretanide capsules on systolic and diastolic blood pressure during standardized ergometric and isometric exercise." | 3.67 | The effects of piretanide capsules on blood pressure during ergometric and isometric work loads in patients with mild to moderate essential hypertension. ( Maass, L; Meywald, W; Rangoonwala, B; Verho, M, 1985) |
| "The serum uric acid level varies during pregnancy." | 3.67 | [Blood uric acid and arterial hypertension in pregnancy. Interpretation and prognostic value]. ( Bonhomme, J; Dagousset, P, 1985) |
| "Spironolactone, an aldosterone antagonist, was given in a daily dose of 100 mg to 15 patients with primary hypertension for one year." | 3.66 | The effect of spironolactone on lipid, glucose and uric acid levels in blood during long-term administration to hypertensives. ( Falch, DK; Schreiner, A, 1983) |
| "Plasma renin activity (PRA), plasma aldosterone (PA), blood uric acid (BUA), plasma concentrations of catecholamines (Pcat) and plasma volume (PV) were measured simultaneously in 24 patients with pregnancy-induced hypertension (PIH)." | 3.66 | Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension. ( Boulanger, JC; Carayon, A; Coevoet, B; Comoy, E; de Fremont, JF; Demory, JE; Desailly, I; Fievet, P; Pleskov, L; Verhoest, P, 1983) |
| " The following significant differences were observed in the study group versus the controls: high systolic and diastolic blood pressure, longer duration of hypertension before renal allografting, higher serum concentrations of cholesterol, triglycerides and uric acid, and an increased incidence of left ventricular hypertrophy and preexisting cardiovascular disease." | 3.66 | [Cardiovascular diseases after kidney transplantation: an analysis of predisposing factors]. ( Binswanger, U; Heule, H; Keusch, G; Largiadèr, F; Uhlschmid, G, 1981) |
| "The effects on blood pressure and renal function of a single 20-mg sublingual dose of nifedipine were investigated in 10 patients with mild to moderate arterial hypertension insufficiently treated on beta-blocker monotherapy." | 3.66 | Renal effects of acute calcium blockade with nifedipine in hypertensive patients receiving beta-adrenoceptor-blocking drugs. ( Christensen, CK; Lederballe Pedersen, O; Mikkelsen, E, 1982) |
| "Thiazide diuretics and loop-diuretics, often used for treatment of hypertension, interfere with various metabolic reactions: An increase of uric acid in plasma is a regular finding, but gout will not be caused, an elevation of plasma lipoproteins has been observed but did not proceed to pathological values, in a number of patients blood glucose has been raised but without producing diabetes mellitus." | 3.66 | [Metabolic effects of diuretics (author's transl)]. ( Kewitz, H; Weber, W, 1981) |
| "A prospective longitudinal study was conducted, looking at the changes in serum uric acid during pregnancy in women who were normotensive at initial presentation." | 3.66 | Serum uric acid as a marker of pregnancy-induced hypertension. ( Hickman, PE; Michael, CA; Potter, JM, 1982) |
| "The association of serum uric acid (SUA) with hypertension, ischemic ECG change, diabetes mellitus, and drinking and smoking habits was studied by multivariate analysis among 1871 residents aged 40 and over in Hisayama, Japan." | 3.66 | The relationship of serum uric acid to hypertension and ischemic heart disease in Hisayama population, Japan. ( Hirota, Y; Okada, M; Omae, T; Takeshita, M; Ueda, K, 1982) |
| "Intrarenal handling of uric acid was studied in 12 patients with essential hypertension under spironolactone treatment (200 mg/day)." | 3.66 | Changes in intrarenal uric acid handling during chronic spironolactone treatment in patients with essential hypertension. ( Boer, P; Dorhout Mees, EJ; Peuker, KH; Roos, JC, 1982) |
| "Serum uric acid concentrations and the fractional excretion of uric acid were determined in 31 children from 3 1/2 to 18 years of age with essential hypertension." | 3.66 | Uric acid in childhood essential hypertension. ( Baluarte, HJ; Gruskin, AB; Polinsky, MS; Prebis, JW, 1981) |
| "A total of 2,923 elderly subjects were studied to determine the relationship between obesity, hypertension, thyroid disease, renal function, alcohol consumption, selected drugs, and the serum uric acid level." | 3.66 | Selected physiologic and drug effects on serum uric acid levels in an elderly population. ( Hale, WE; Marks, RG; Stewart, RB; Yost, RL, 1981) |
| "Male and female, Sprague-Dawley rats, with and without arteriosclerosis, were subjected to chronic treatment with furosemide for 4 weeks." | 3.66 | Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats. ( Wexler, BC, 1981) |
| " Regression analysis revealed statistically significant changes of systolic and diastolic blood pressures, fasting blood glucose, serum cholesterol, serum triglycerides and serum uric acid with changes in body weight." | 3.66 | Body weight change in relation to incidence of ischemic heart disease and change in risk factors for ischemic heart disease. ( Noppa, H, 1980) |
| "The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension." | 3.66 | A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980) |
| " In 17 subjects with gout, blood uric acid levels were reduced by approximately 50%." | 3.66 | Tienilic acid: a single treatment for hyperuricaemia and hypertension? ( Gibson, T; Potter, CF; Rodgers, VA; Simmonds, HA, 1980) |
| "Fifty-two middle-aged patients with essential hypertension were treated for five months with 25 mg mefruside as the only antihypertensive drug." | 3.66 | Effects of mefruside treatment in hypertension. ( Bergengren, B; Henningsen, NC; Malmborg, O; Pihl, O; Renmarker, K; Strand, L, 1980) |
| "In 23 patients with essential hypertension of stage I and II according to the WHO, the effects of a fixed combination of a beta-receptor-blocker plus saluretic composed of 20 mg of metipranolol (Disorat 20) and 2." | 3.66 | [Metabolic effects of a fixed combination (betablocker plus saluretic) in long-term treatment of arterial hypertension (author's transl)]. ( Faupel, RP; Gotzen, R, 1979) |
| " The routine determination of uric acid concentration in serum seems to be of no great value for predicting pregnancy-induced hypertension, compared with the roll-over test or with the angiotensin sensitivity test; however, it gives an additional information (a) in pregnancy women with questionable gestosis, and (b) in the differential diagnosis of pregnancy-induced versus pre-existing essential hypertension." | 3.66 | [Methods for the early recognition of gestosis]. ( Kaulhausen, H; Oney, T, 1979) |
| "A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease." | 3.66 | Elevated serum uric acid. A cardiovascular risk factor? ( Fodor, JG; Tweeddale, MG, 1979) |
| "The authors have carried out research in 58 cases to see whether the findings of high uric acid levels in the blood are of prognostic value in all cases of arterial hypertension in pregnancy whatever the aetiology." | 3.66 | [The prognostic value of raised uric acid in the blood in arterial hypertension in pregnancy. 58 cases (author's transl)]. ( Cotteel, M; Delecour, M; Dequiedt, P; Leroy, JL; Potier, A; Puech, F; Tacquet, A, 1979) |
| "Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension." | 3.66 | Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study. ( Helgeland, A; Hjermann, I; Holme, I; Leren, P, 1978) |
| "To study whether the renin-angiotensin system is related to hyperuricemia in hypertension, the serum concentration of uric acid was determined in 96 patients with various types of hypertension and various degrees of plasma renin activity (PRA)." | 3.66 | Serum uric acid and the renin-angiotensin system in hypertension. ( Kato, E; Kondo, K; Nakamura, R; Oguro, T; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978) |
| "Eleven patients with hypertension secondary to renal disease were treated with hydrochlorothiazide or furosemide plus other drugs to normalize blood pressure." | 3.66 | Use of diuretics in treatment of hypertension secondary to renal disease. ( Bank, N; Lief, PD; Piczon, O, 1978) |
| " 91% have serum uric acid levels above the normal range and 61% present "hyperuricemia," according to "gouty risk" criteria." | 3.65 | [Occurrence of hyperuricemia in atrioventricular block. (Results of a study of 158 patients with isotopic pacemaker implantations)]. ( Gavelle, P; Laurens, P; Maurice, P, 1976) |
| "Healthy virgin and breeder rats (Sprague-Dawley) with naturally occurring hypertension and arteriosclerosis were fed 5% oxonic acid and 1% uric acid added to their regular diet for 30 days." | 3.65 | Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis. ( Greenberg, BP; Wexler, BC, 1977) |
| " Data on blood pressure, obesity and serum lipids are presented here, and are discussed together with smoking and serum uric acid." | 3.65 | Coronary risk factors in New Zealand Maori and European adolescents: The Rotoua Lakes Study 2. ( Malcolm, JB; Stanhope, JM, 1975) |
| "Both the average serum uric acid and annual increment were determined in 250 treated patients attending a hypertension clinic." | 3.65 | Serum uric acid in hypertensive patients. ( Bulpitt, CJ, 1975) |
| " In this review, we discuss recent advances and novel insights into the effects exerted by HUA conditions in ED and related underlying mechanisms focusing on impaired UA metabolism, reduction in the synthesis and bioavailability of nitric oxide, endothelial cell injury, the endothelial-to-mesenchymal transition, insulin resistance, procoagulant activity, and acquisition of an inflammatory phenotype." | 3.01 | Hyperuricemia: A key contributor to endothelial dysfunction in cardiovascular diseases. ( He, Y; Huang, S; Lan, X; Lei, W; Luo, H; Wei, X; Zhang, M; Zheng, J, 2023) |
| "Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common." | 2.84 | Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans. ( Johnson, RJ; Kelly, J; MacGinley, RJ; Major, TJ; Merriman, TR; Todd, AS; Walker, RJ, 2017) |
| "Superimposed preeclampsia complicates about 20% of pregnancies in women with chronic hypertension and is associated with increased maternal and perinatal morbidity compared with preeclampsia alone." | 2.82 | Chronic hypertension and superimposed preeclampsia: screening and diagnosis. ( Kametas, NA; Nicolaides, KH; Nzelu, D, 2022) |
| "Hypertension is common in CKD patients and many mechanisms inducing it (upregulation of renin-angiotensin-aldosterone system, endothelial dysfunction and atherosclerosis) may be influenced by XOR products." | 2.82 | Chronic kidney disease: Which role for xanthine oxidoreductase activity and products? ( Battelli, MG; Bolognesi, A; Bortolotti, M; Polito, L, 2022) |
| "We studied 62 patients with untreated hypertension, randomly assigned to cilnidipine or amlodipine for 48 weeks." | 2.82 | Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients. ( Eguchi, A; Fujiwara, S; Hirotani, S; Komamura, K; Koshiba, M; Mano, T; Masaki, M; Masuyama, T; Sugahara, M; Tsujino, T, 2016) |
| "The treatment with eplerenone significantly increased serum potassium levels, whereas the treatment with indapamide significantly decreased them." | 2.80 | Effects of a selective aldosterone blocker and thiazide-type diuretic on blood pressure and organ damage in hypertensive patients. ( Hayashi, S; Ishizuka, A; Iwashima, Y; Kawano, Y; Kishida, M; Nakamura, S; Ohta, Y; Yoshihara, F, 2015) |
| "Azelnidipine was administered to 72 patients at a daily dose of 8 mg or 16 mg." | 2.79 | Effects of azelnidipine on uric acid metabolism in patients with essential hypertension. ( Cheng, J; Hamada, T; Hirata, S; Hisatome, I; Igawa, O; Kato, M; Kuwabara, M; Miyazaki, S; Mizuta, E; Moriwaki, Y; Ninomiya, H; Nosaka, Y; Ogino, K; Ohtahara, A; Yamamoto, K; Yamamoto, Y; Yoshida, A, 2014) |
| "Perindopril/indapamide is an effective and safe antihypertensive treatment in everyday medical practice." | 2.78 | Blood pressure and metabolic efficacy of fixed-dose combination of perindopril and indapamide in everyday practice. ( Farsang, C, 2013) |
| " Although blood levels of potassium, hemoglobin A1c and uric acid (UA) significantly increased after 3 months for all of the patients, none of the patients showed serious adverse effects." | 2.77 | Efficacy and safety of a single-pill fixed-dose combination of high-dose telmisartan/hydrochlorothiazide in patients with uncontrolled hypertension. ( Arimura, T; Fujisawa, K; Inoue, A; Kuwano, T; Matsunaga, E; Mitsutake, R; Miura, S; Morii, J; Nagata, I; Norimatsu, K; Saku, K; Shiga, Y; Shimizu, T; Shirotani, T; Uehara, Y, 2012) |
| "Many patients with hypertension have difficulty achieving their target blood pressure (BP)." | 2.77 | Efficacy and effect on plasma B-type natriuretic peptide concentration of losartan-hydrochlorothiazide for hypertension uncontrolled by losartan-based therapy: subanalysis of a Multicentre Prospective Observational Study. ( Inou, T; Kobayashi, K; Kubara, I; Meno, H; Nakamura, Y; Ota, T; Shiga, Y; Tanaka, M; Tsuchiya, Y, 2012) |
| " There were no significant differences in the incidences of clinical and laboratory drug-related adverse events between any of the combination groups and the placebo group." | 2.73 | Antihypertensive efficacy and safety of fixed-dose combination therapy with losartan plus hydrochlorothiazide in Japanese patients with essential hypertension. ( Hirayama, Y; Matsuoka, H; Nonaka, K; Ogihara, T; Saruta, T; Suzuki, H; Takahashi, K; Toki, M, 2007) |
| " The most commonly reported adverse events are dizziness, headache, fatigue, upper respiratory tract infection and urinary tract infection." | 2.72 | Evaluating the Safety and Tolerability of Azilsartan Medoxomil Alone or in Combination With Chlorthalidone in the Management of Hypertension: A Systematic Review. ( Antonopoulos, AS; Katsi, V; Michalakeas, C; Soulaidopoulos, S; Tousoulis, D; Tsioufis, K; Vlachopoulos, C, 2021) |
| "Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression." | 2.72 | Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. ( Kwan, TH; Leung, KT; Siu, YP; Tong, MK, 2006) |
| "Lercanidipine is a calcium channel blockers of high efficacy and low incidence of adverse effects in the clinical settings of general practice." | 2.71 | [Evaluation of lercanidipine in the general practice setting]. ( Aguilar, A; Angulo, E; Canelada, JA; Cidoncha, F; Díaz Olea, E; Fuentes, J; Garrido, J; Guerras, M; Hidalgo, P; Iglesias, M; Lapie, J; López Acedo, A; Peña, J; Robles, NR, 2003) |
| "Indapamide is an antihypertensive agent similar to thiazides, but with some different effects." | 2.71 | Effect of indapamide on urinary calcium excretion in patients with and without urinary stone disease. ( Algun, E; Can, S; Ceylan, K; Dogan, E; Erkoc, R; Gonulalan, H; Sayarlioglu, H; Topal, C; Yilmaz, Y, 2005) |
| "A total of 422 patients with type 2 diabetes who were hypertensive [sitting systolic blood pressure (SBP) > or = 140 mmHg and/or diastolic blood pressure (DBP) > or = 90 mmHg] and microalbuminuric [urinary albumin excretion (UAE) 30-300 mg/day] were eligible for the study." | 2.70 | Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics. ( Aznar, J; Llisterri, JL; Lozano, JV; Redon, J, 2001) |
| "Losartan has been shown to increase urinary uric acid excretion and hence to lower serum uric acid levels." | 2.70 | Comparative effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricaemia and gout. ( Brunner, HR; Burnier, M; Chiolero, A; Fallab-Stubi, CL; Gerster, JC; Maillard, M; Würzner, G, 2001) |
| "Losartan decreased serum uric acid and increased uric acid excretion without increasing urinary dihydrogen urate, the primary risk factor for acute urate nephropathy, during 21 days of dosing in hypertensive patients with thiazide-induced hyperuricemia." | 2.69 | Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia. ( Carides, AD; Coe, FL; Nakagawa, Y; Parks, JH; Shahinfar, S; Simpson, RL; Thiyagarajan, B; Umans, JG, 1999) |
| " A dose-response relationship to losartan was observed in this patient population." | 2.68 | Effects of losartan on a background of hydrochlorothiazide in patients with hypertension. ( Goldberg, AI; Pratt, JH; Soffer, BA; Sweet, CS; Wiens, B; Wright, JT, 1995) |
| "In contrast, hyperinsulinemia caused a significant decrease in the urinary excretion of uric acid (2." | 2.68 | Effect of insulin on renal sodium and uric acid handling in essential hypertension. ( Bianchi, S; Bigazzi, R; Ciociaro, D; Ferrannini, E; Frascerra, S; Galvan, AQ; Muscelli, E; Natali, A; Sironi, AM, 1996) |
| " The acute pharmacodynamic actions of intravenous (i." | 2.67 | Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. ( Berman, RS; Bradstreet, DC; Jallard, N; Saenz, A; Sweet, CS; Weidler, DJ, 1994) |
| " Adverse events were reported in 11 of the 38 patients in the ramipril group, in 22 of 83 patients treated with the combination for more than 50 weeks, and in 9 of 38 patients treated with the combination for 50 weeks or less." | 2.67 | Efficacy and safety of ramipril in combination with hydrochlorothiazide: results of a long-term study. ( Bauer, B; Breitstadt, A; Cairns, V; Froer, KL; Heidbreder, D, 1991) |
| " We conclude that the cyclosporine blood level was a better discriminant than cyclosporine dosage in the analysis of renal dysfunction and hypertension in these patients." | 2.67 | Short-term changes in renal function, blood pressure, and electrolyte levels in patients receiving cyclosporine for dermatologic disorders. ( Brown, MD; Ellis, CN; Goldfarb, MT; Gupta, AK; Rocher, LL; Schmaltz, SP; Voorhees, JJ, 1991) |
| "When captopril was added to hydrochlorothiazide, a significant attenuation of the diuretic effect on potassium and uric acid was observed, and the significant change in blood sugar and cholesterol seen with the diuretic alone was prevented." | 2.66 | Blood pressure and metabolic responses to hydrochlorothiazide, captopril, and the combination in black and white mild-to-moderate hypertensive patients. ( Weinberger, MH, 1985) |
| "Bendroflumethiazide 5 mg was given to 17 patients with essential hypertension who had persistent mild to moderate hypertension despite treatment with nifedipine slow-release tablets 20 mg bid." | 2.66 | The effects of bendroflumethiazide added to nifedipine in patients with hypertension. ( Beevers, DG; Gill, JS; Zezulka, AV, 1987) |
| "The antihypertensive and biochemical effects of 25 mg hydrochlorothiazide alone or 50 mg hydrochlorothiazide alone or in combination with triamterene (either 37." | 2.66 | Antihypertensive and biochemical effects of different doses of hydrochlorothiazide alone or in combination with triamterene. ( Eisalo, A; Gordin, A; Kohvakka, A; Salo, H, 1986) |
| "The purpose of this study was to determine the effects on blood pressure and selected biochemical measures of reducing the dosage of chlorthalidone from 100 mg to 50 mg." | 2.66 | Beneficial effects from systematic dosage reduction of the diuretic, chlorthalidone: a randomized study within a clinical trial. ( Allen, R; Bailey-Hoffman, G; Case, J; Childs, J; Grimm, RH; Hulley, SB; Kousch, D; McDonald, M; McGill, E; Neaton, JD, 1985) |
| "Counts of ventricular extrasystoles were significantly higher (p = 0." | 2.65 | Ventricular extrasystoles during thiazide treatment: substudy of MRC mild hypertension trial. ( , 1983) |
| "Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage." | 2.65 | Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983) |
| " They received in random order: placebo; tienilic acid 250 mg/day; propranolol 80 mg twice daily; and tienilic acid 250 mg/day combined with propranolol 80 mg twice daily." | 2.65 | Biochemical and haematological changes induced by tienilic acid combined with propranolol in essential hypertension. ( Bulpitt, CJ; Havard, CW; Pearson, RM, 1979) |
| "Ten patients with congestive heart failure, on full digitalis treatment, were given TA (dose range 250-1000 mg/die): in each patient a prompt diuretic effect was observed, associated to a significant reduction of body weight and to a marked improvement of the clinical signs of heart failure." | 2.65 | [Tienilic acid in the treatment of arterial hypertension and congestive cardiac insufficiency]. ( Agabiti-Rosei, E; Alicandri, C; Corea, L; Fariello, R; Muiesan, G; Oldoni, T, 1979) |
| " Blood pressure was significantly reduced with both medications, although most patients required an increase in dosage from 250 to 500 mg ticrynafen daily." | 2.64 | Clinical study of ticrynafen. A new diuretic, antihypertensive, and uricosuric agent. ( Freis, ED; Kyle, MC; Nemati, M, 1977) |
| " A reduction in dosage from 50 mg daily to 50 mg three times a week produced no significant changes in the diastolic or mean blood pressures though the systolic blood pressure was moderately increased." | 2.64 | Effect of different doses of chlorthalidone on blood pressure, serum potassium, and serum urate. ( Bengtsson, C; Johnsson, G; Sannerstedt, R; Werkö, L, 1975) |
| "Hyperuricemia affects one out of five adults as a result of the Western diet, insulin resistance, and renal dysfunction." | 2.61 | Uric acid and hypertension: a focused review and practical recommendations. ( Borghi, C; Burnier, M; De Becker, B; van de Borne, P, 2019) |
| "Hyperuricemia has recently emerged as an independent risk factor in the development of type 2 diabetes mellitus and hypertension through several proposed mechanisms." | 2.55 | Hyperuricemia, Type 2 Diabetes Mellitus, and Hypertension: an Emerging Association. ( Mortada, I, 2017) |
| "Hyperuricemia has long been known to cause gout, and has recently been correlated with cardiovascular disease, hypertension, and renal disease." | 2.55 | The role of urate-lowering treatment on cardiovascular and renal disease: evidence from CARES, FAST, ALL-HEART, and FEATHER studies. ( Pontremoli, R, 2017) |
| "If hyperuricemia is an independent risk factor in blood-pressure control, urate-lowering therapy should be used to reduce cardiovascular risk." | 2.55 | Effects of serum uric acid on blood-pressure lowering treatment. ( Grassi, G, 2017) |
| "Uric acid is a product of purine metabolism and has been linked to gout and kidney calculi." | 2.53 | Hyperuricemia, Hypertension, and Chronic Kidney Disease: an Emerging Association. ( Al Kattar, S; Jurjus, A; Mallat, SG; Tanios, BY, 2016) |
| "Hyperuricemia is associated with hypertension, kidney disease, vascular and cardiovascular (CV) events." | 2.52 | Hyperuricemia, urate deposition and the association with hypertension. ( Borghi, C; Grassi, G; Mancia, G, 2015) |
| "Hypertension is an established risk factor of cardiovascular morbidity and mortality." | 2.52 | [The First Step Aiming at the Prevention of Hypertension and Atherosclerosis. Identification of Individuals at High Risk of Hypertension]. ( Dohi, Y, 2015) |
| "Uric acid is a waste product of purine catabolism." | 2.49 | Uric acid as a danger signal in gout and its comorbidities. ( Kataoka, H; Lai, JJ; Rock, KL, 2013) |
| "Hypocitraturia and hypercalciuria are risk factors for calcium stone disease." | 2.47 | Diet-induced metabolic acidosis. ( Adeva, MM; Souto, G, 2011) |
| "Hyperuricemia is a specific risk factor for cardiovascular morbidity and mortality." | 2.47 | [Hyperuricemia and uro-nephrological disorders]. ( Hurtes, X; Meria, P, 2011) |
| "Hyperuricemia is considered to be a risk factor of not only gout but also renal and cardiovascular diseases, thus, it is important to use CCBs without adverse effect on uric acid metabolisms." | 2.46 | [Calcium antagonists: current and future applications based on new evidence. The mechanisms on lowering serum uric acid level by calcium channel blockers]. ( Hamada, T; Hisatome, I; Igawa, O; Mizuta, E; Shigemasa, C, 2010) |
| "Uric acid is a major product of purine metabolism in humans." | 2.46 | Uric acid and the development of hypertension. ( Hwu, CM; Lin, KH, 2010) |
| "Uric acid has previously been viewed as a benign solute in serum until it exceeds its saturation level." | 2.45 | The role of hyperuricemia in vascular disorders. ( Edwards, NL, 2009) |
| "Calcium antagonists are used in the treatment of hypertension and angina." | 2.44 | The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension. ( Coca, A; Sierra, C, 2008) |
| "Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system." | 2.44 | Uric acid: bystander or culprit in hypertension and progressive renal disease? ( Menè, P; Punzo, G, 2008) |
| "Thus, the treatment of hypertension and hyperlipidemia associated with hyperuricemia is also important." | 2.44 | [Other antihyperuricemic agents]. ( Hisatome, I; Igawa, O; Ogino, K, 2008) |
| "Hypertension is epidemic and currently affects 25% of the world's population and is a major cause of stroke, congestive heart failure, and end-stage renal disease." | 2.43 | Uric acid, evolution and primitive cultures. ( Cade, JR; Johnson, RJ; Oliver, WJ; Rideout, BA; Titte, S, 2005) |
| "Hypertension is the most common form of cardiovascular disease." | 2.43 | Uric acid and hypertension in adolescents. ( Feig, DI, 2005) |
| "Uric acid may increase as a result of pathophysiological processes such as impaired renal sodium handling but may also contribute to renal and vascular damage, particularly endothelial dysfunction." | 2.43 | Uric acid and hypertension. ( Schachter, M, 2005) |
| "Low birth weight due to intrauterine growth restriction is associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance and end-stage renal disease." | 2.43 | Consequences of intrauterine growth restriction for the kidney. ( Delemarre-van de Waal, H; Schreuder, M; van Wijk, A, 2006) |
| "Hyperuricemia has long been known to be associated with cardiovascular disease, and it is particularly common in people with hypertension, metabolic syndrome, or kidney disease." | 2.43 | Role of uric acid in hypertension, renal disease, and metabolic syndrome. ( Heinig, M; Johnson, RJ, 2006) |
| "Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events." | 2.42 | Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? ( Feig, D; Herrera-Acosta, J; Johnson, RJ; Kanellis, J; Kang, DH; Kivlighn, S; Mazzali, M; Rodriguez-Iturbe, B; Tuttle, KR; Watanabe, S, 2003) |
| "In the treatment of hypertension, especially with hyperuricemia, it might be important to select the drug, which does not influence or reduce the concentration of uric acid." | 2.41 | [Hyperuricemia in hypertension]. ( Saito, Y; Tatsuno, I, 2001) |
| "Indapamide SR 1." | 2.41 | Metabolic profile of indapamide sustained-release in patients with hypertension: data from three randomised double-blind studies. ( Weidmann, P, 2001) |
| "The defect observed in preeclampsia is the lack of invasion of the trophoblast to the maternal arteries." | 2.40 | [Observations on pe-eclampsia-eclampsia and the advances in the evolution of some laboratory tests]. ( Arredondo Soberón, F; Ayala Barahona, T; Morgan, MA; Noguera Sánchez, MF, 1997) |
| "One hundred sixty NIDDM patients who had undergone the clamp study were stratified into 5 groups according to the serum uric acid level." | 2.39 | [Hyperuricemia and insulin resistance]. ( Iwatani, M; Katsumori, K; Saeki, A; Wasada, T, 1996) |
| "Diuretics have long been used in the treatment of hypertension and are outstandingly efficacious when used either alone or in combination with other antihypertensive compounds." | 2.38 | Diuretics in hypertension: clinical experiences. ( Papademetriou, V, 1992) |
| " Some of these disorders may be worsened by the chronic administration of antihypertensive drugs like diuretics, beta-adrenoceptor antagonists, and the angiotensin converting enzyme inhibitors." | 2.38 | Metabolic effects of antihypertensive drugs. ( Oh, VM, 1989) |
| "Xipamide is a diuretic derived from salicylic acid and has a structural resemblance to chlorthalidone." | 2.37 | Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. ( Brogden, RN; Prichard, BN, 1985) |
| "Depression is a common psychiatric health issue affecting an estimated 5% of adults worldwide, and it can lead to disability and increased economic burden." | 1.91 | Sex difference in the associations among risk factors with depression in a large Taiwanese population study. ( Chen, SC; Geng, JH; Lee, JI; Tseng, H, 2023) |
| "Apparent treatment-resistant hypertension (aTRH) was defined as a SBP ≥ 140 mmHg or DBP ≥ 90 mmHg with concurrent use of three classes of antihypertensive medications, or taking four or more classes of antihypertensive medication regardless of BP level." | 1.91 | Hypertension severity, apparent treatment resistant hypertension and hyperuricemia in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. ( Bridges, SL; Chaudary, N; Colantonio, LD; Cushman, M; Howard, G; Irvin, MR; Limdi, N; Merriman, TR; Muntner, P; Reynolds, RJ; Saag, K; Tanner, RM, 2023) |
| " The association between low SUA and mortality and the dose-response analysis on the non-linearity of SUA-mortality relationship were not statistically significant." | 1.91 | Association of serum uric acid levels with cardiovascular and all-cause mortality in hypertensive patients in China: a cohort study. ( Chen, JY; Feng, YQ; Lo, K; Tang, ST; Yu, YL; Zhang, SX, 2023) |
| "Uric acid stones were associated with medical conditions such as diabetes, hypertension, ischemic heart disease, and obesity (28." | 1.91 | The relationship between patients' kidney stone type and demographics in Israel: analysis of 10 K patients. ( Cohen, S; Dekel, Y; Friefeld, Y; Klein, I; Pilosov Solomon, I; Saliba, W; Tor, R; Zreik, R, 2023) |
| "Uric acid (UA) is an independent prognostic factor for cardiovascular events, but there are no data demonstrating a different risk profile between women and men." | 1.91 | Sex-related differences for uric acid in the prediction of cardiovascular events in essential hypertension. A population prospective study. ( Andreozzi, F; Caroleo, B; Gigliotti, S; Maio, R; Perticone, F; Perticone, M; Sciacqua, A; Shehaj, E; Suraci, E, 2023) |
| "Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males." | 1.72 | Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults. ( Bao, Q; Cai, S; Cheng, B; Li, M; Ma, S; Su, Y; Sun, J; Sun, M; Wang, S; Zhang, A; Zhang, Y; Zhu, P, 2022) |
| "Cardio-metabolic diseases and Parkinson's disease were more frequent in men with hypouricaemia than those without hypouricaemia." | 1.72 | Temporal trends in the prevalence and characteristics of hypouricaemia: a descriptive study of medical check-up and administrative claims data. ( Kawakami, K; Koto, R; Kuwabara, M; Sato, I; Seki, T, 2022) |
| "Chronic kidney disease and left ventricular hypertrophy are potent modifiers of the prognostic value of the circadian BP changes." | 1.72 | Chronic Kidney Disease and Left Ventricular Hypertrophy. Potent Modifiers of the Prognostic Impact of Circadian Blood Pressure Changes. ( Angeli, F; Reboldi, G; Verdecchia, P, 2022) |
| "Uric acid (UA) is a risk factor associated with cardiometabolic diseases." | 1.72 | Serum Uric Acid Levels and Cardiometabolic Profile in Middle-Aged, Treatment-Naïve Hypertensive Patients. ( Kalaitzidis, RG; Theofilis, P; Tsimihodimos, V; Vordoni, A, 2022) |
| " The potential risk factors for the discontinuation events caused by sac/val-related adverse events (AEs) were explored." | 1.72 | Effectiveness and safety of sacubitril/valsartan for patients with hypertension and heart failure in the real-world setting: A retrospective study in China. ( Chen, C; Fan, L; Li, J; Li, X; Lv, Q; Tian, D; Zuo, C, 2022) |
| " In addition, the dose-response curve was also used to discuss the relationship between SUA and pSS-HT." | 1.72 | Relationship between serum uric acid and hypertension in patients with primary Sjögren's syndrome: A retrospective cohort study. ( Luo, Q; Qin, L; Wang, H; Yang, X; Zhang, Y, 2022) |
| "Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria." | 1.72 | Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice. ( Baumann, MU; Lüscher, BP; Schoeberlein, A; Surbek, DV, 2022) |
| "Hypertension was defined as SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg or self-reported recent use of anti-hypertensive medications." | 1.72 | Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults. ( Ahmed, S; Ali, N; Barman, Z; Fariha, KA; Hasan, A; Hasan, M; Miah, R; Mohanto, NC; Mou, AD; Sony, SA, 2022) |
| " Logistic regression models were used to estimate the association between LAP and HWH risk, restricted cubic splines (RCS) were used to analyze the dose-response relationship between them." | 1.72 | The lipid accumulation product (LAP) association with hyperuricemic hypertension in the China Health and Nutrition Survey: A cross-sectional study. ( Geng, Y; Ping, Z; Shang, Y; Wang, H; Wang, J; Yin, X; Zhou, M, 2022) |
| "Hyperuricemia was an independent risk factor of leukocyte in Tertile 3 (odds ratio [OR] = 1." | 1.72 | The relationship between leukocyte level and hypertension in elderly patients with hyperuricemia. ( Dong, Y; Li, M; Liu, Y; Shen, L; Zhang, J; Zhao, W; Zhou, Z, 2022) |
| " The dose-response relationship of SUACr and MetS was further assessed by a restricted cubic spline model (RCS)." | 1.72 | Association of the serum uric acid to creatinine ratio with metabolic syndrome in the middle age and older population in China. ( Guo, Y; Huang, H; Huang, S; Li, L; Liu, D; Wu, F; Zhong, D, 2022) |
| "The data regarding preeclampsia and its associated risk factors are scarce or limited in pregnant women in Bangladesh." | 1.62 | Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. ( Ali, N; Barman, Z; Das Trisha, A; Hafsa, JM; Hasan, M; Miah, R; Mou, AD, 2021) |
| " The lower risk of incident HTN after xanthine oxidase inhibitors exhibited a significant dose-response trend." | 1.62 | Urate-lowering therapy exerts protective effects against hypertension development in patients with gout. ( Hsu, CC; Hwu, CM; Li, HL; Lin, KH; Wei, JC; Yang, CC; Yen, FS, 2021) |
| "Hypertension is a growing clinical problem in pediatric population." | 1.62 | Dental caries-related primary hypertension in children and adolescents: Cross-sectional study. ( Dmitrzak-Węglarz, M; Neyman-Bartkowiak, A; Nowicki, M; Ostalska-Nowicka, D; Paszyńska, E; Rabiega, A; Zachwieja, J, 2021) |
| "Hyperuricemia has been associated with hypertension, however, whether this association exists across all decades of adult life is unknown." | 1.62 | Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population. ( Charchar, FJ; Drummond, GR; Golledge, J; Hou, X; Hu, W; Qian, T; Sobey, CG; Sun, H; Wang, Y; Xu, Q; Yang, G; Zhang, G, 2021) |
| "Urolithiasis is considered a vital public health issue with a substantial burden on kidney function." | 1.62 | A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease? ( Chang, HW; Chien, TM; Chou, YH; Li, CC; Lu, YM; Wu, WJ, 2021) |
| "Gout has significant impact on the quality of life with over-utilisation of health resources." | 1.56 | Burden and management of gout in a multi-ethnic Asian cohort. ( Cheung, PP; Chua, CKT; Lim, AYN; Santosa, A; Teng, GG, 2020) |
| "Hyperuricemia has been reported to be a risk factor for hypertension, but this association may be affected by alcohol consumption." | 1.56 | Hyperuricemia predicts the risk for developing hypertension independent of alcohol drinking status in men and women: the Saku study. ( Asayama, K; Izawa, S; Miyamatsu, N; Miyamoto, Y; Morimoto, A; Ohkubo, T; Ohno, Y; Satoh, M; Sonoda, N; Tatsumi, Y, 2020) |
| "In particular, apparent treatment-resistant hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg on 3 antihypertensive medications or use of ≥4 antihypertensive medications) and the count of antihypertensive medication classes significantly reduced the effect of hyperuricemia on ischemic stroke." | 1.56 | Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study. ( Bridges, SL; Chaudhary, NS; Colantonio, LD; Curtis, JR; Cushman, M; Flaherty, ML; Gaffo, A; Howard, G; Irvin, MR; Judd, S; Levitan, EB; Limdi, NA; Rahn, EJ; Reynolds, RJ; Saag, KG; Singh, JA, 2020) |
| "Hyperuricemia has been associated with metabolic syndrome, and the association with various cardiometabolic risk factors may be affected by sex." | 1.56 | Sex-specific association of hyperuricemia with cardiometabolic abnormalities in a military cohort: The CHIEF study. ( Hoshide, S; Kwon, Y; Lee, JT; Lin, CS; Lin, GM; Lin, YK; Lin, YP; Su, FY; Tsai, KZ; Wu, TJ, 2020) |
| "Hypertension is a major public health problem of adult population across the globe that significantly increases the risk of heart attack, stroke, kidney failure and blindness." | 1.56 | Evaluation of Serum Uric Acid and Serum Creatinine in Male Hypertensive Patients. ( Akter, N; Dipa, MI; Firoz, S; Islam, MF; Israt, S; Nessa, A; Rahman, HH; Sharmin, A, 2020) |
| "Hypertension is the most important modifiable risk factor for stroke and is associated with poorer post-stroke outcomes." | 1.56 | Uric Acid Treatment After Stroke Prevents Long-Term Middle Cerebral Artery Remodelling and Attenuates Brain Damage in Spontaneously Hypertensive Rats. ( Chamorro, Á; Dantas, AP; Jiménez-Altayó, F; Jiménez-Xarrié, E; Martí-Fabregas, J; Pérez, B; Planas, AM; Puertas-Umbert, L; Vila, E, 2020) |
| "For instance, hypertension is found in 36-41% gout patients, and combined with metabolic syndrome it may reach 80%." | 1.51 | Role of immune system in development and progress of combined arterial hypertension and gout. ( Bychkov, ОА; Bychkova, NG; Bychkova, SA; Kondratiuk, VE; Morozova, ZV; Tarasiuk, AP, 2019) |
| "Uric acid has been reported to activate Nod-like receptor protein 3 (NLRP3)-inflammasome and alter vascular smooth muscle cells (VSMC)." | 1.51 | Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. ( Li, H; Liu, H; Qian, F; Zhang, Z, 2019) |
| "Introduction: Hyperuricemia is an independent risk factor for high-normal blood pressure (BP) both in men and women." | 1.51 | The influence of uric acid level on erythrocyte morphology in normotensive patients. ( Kovalenko, YL; Melekhovets, OK; Melekhovets, YV; Orlovskiy, VF, 2019) |
| "Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD)." | 1.51 | Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the Blood Pressure control rate and CArdiovascular Risk profilE study. ( Bombelli, M; Facchetti, R; Grassi, G; Lurbe, E; Maloberti, A; Mancia, G; Redon, J; Redon, P, 2019) |
| "Whether hyperuricemia affects biological response to acute stress remains largely unknown, suggesting a need to clarify this potential connection." | 1.51 | Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans. ( Granger, DA; Lucas, T; Pierce, J; Riis, JL; Woerner, J, 2019) |
| "Incident hypertension has been defined as the increase of SBP values over 140 mmHg and/or of DBP over 90 mmHg and or the beginning of an antihypertensive treatment." | 1.51 | Interaction between low-density lipoprotein-cholesterolaemia, serum uric level and incident hypertension: data from the Brisighella Heart Study. ( Borghi, C; Cicero, AFG; D'Addato, S; Fogacci, F; Giovannini, M; Grandi, E, 2019) |
| "Hyperuricemia was common in youth with T2D." | 1.51 | Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu ( Bjornstad, P; El Ghormli, L; Laffel, L; Lynch, J; Nadeau, KJ; Tollefsen, SE; Weinstock, RS, 2019) |
| "Uric acid content was associated directly with age and inversely with eGFR, was higher among males, patients with diabetes and high blood pressure." | 1.51 | Stone composition and vascular calcifications in patients with nephrolithiasis. ( Bargagli, M; Bassi, PF; Ferraro, PM; Gambaro, G; Gervasoni, J; Marano, R; Primiano, A; Rovere, G, 2019) |
| "Hypertension is one of the major causes of chronic diseases." | 1.51 | Effects of Prenatal Growth Status on Subsequent Childhood Renal Function Related to High Blood Pressure. ( Cho, SJ; Kim, HS; Lee, JW; Park, B; Park, EA; Park, H, 2019) |
| " The cellular mechanisms that lead to those outcomes require an increase in intracellular concentrations of uric acid inducing oxidative stress that then activates the synthesis and secretion of proinflammatory factors and vasoconstrictive substances, and diminishes the bioavailability of nitric oxide produced by eNOS." | 1.48 | The Pathophysiology of Uric Acid on Renal Diseases. ( Sánchez-Lozada, LG, 2018) |
| "Hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and kidney and cardiovascular diseases." | 1.48 | Renal Effects of Hyperuricemia. ( Méndez Landa, CE, 2018) |
| "Ethnicity and hypertension are predictive of gout risk, and the associations cannot be fully explained by serum urate." | 1.48 | Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities. ( Gaffo, AL; Los Campos, G; Merriman, TR; Reeves, M; Reynolds, RJ; Singh, JA; Sun, M; Vazquez, AI, 2018) |
| "Obesity is a risk factor for hypertension, diabetes mellitus (DM), dyslipidemia, and hyperuricemia." | 1.48 | Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. ( Hisatome, I; Jalal, DI; Johnson, RJ; Kuwabara, M; Kuwabara, R; Lanaspa, MA; MacLean, PS; Niwa, K; Ohno, M; Roncal-Jimenez, CA; Smits, G; Yracheta, JM, 2018) |
| "Treatment with uric acid caused a further reduction in cell viability, while ascorbic acid improved viability." | 1.48 | Effects of uric acid on vascular endothelial function from bedside to bench. ( Anzai, N; Fujita, T; Hayashi, K; Inoue, T; Node, K; Otani, N; Ouchi, M; Sakuma, M; Tanaka, A; Toyoda, S; Uemura, N, 2018) |
| "A total of 232 participants developed cancer." | 1.46 | Association of serum uric acid with increased risk of cancer among hypertensive Chinese. ( Gao, W; Gu, J; Hou, FF; Huo, Y; Jiang, H; Jiang, X; Lei, Y; Qin, X; Shen, L; Wang, B; Wang, X; Wang, Y; Xu, X; Yang, J; Zhang, R; Zhang, X; Zhao, Q, 2017) |
| "Uric acid is a significant predictor of systolic BP and hypertension prevalence in the general adult population in Germany independently of several known dietary BP influences." | 1.46 | Diet-independent relevance of serum uric acid for blood pressure in a representative population sample. ( Esche, J; Krupp, D; Mensink, GB; Neuhauser, HK; Remer, T, 2017) |
| "Uric acid plays an important role in CVD pathogenesis by inducing inflammatory COX-2 and ROS pathways." | 1.46 | Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells. ( Çetin, A; Kırça, M; Oğuz, N; Yeşilkaya, A, 2017) |
| "Urolithiasis is common and is becoming more prevalent worldwide." | 1.46 | Chronological Trends in Clinical and Urinary Metabolic Features over 20 Years in Korean Urolithiasis Patients. ( Ha, YS; Kang, HW; Kim, WJ; Kim, WT; Kim, YJ; Lee, SC; Seo, SP; Yun, SJ, 2017) |
| "Hyperuricemia is associated with cardiovascular disease and its prevalence is unknown in black Africans." | 1.46 | Distribution of Serum Uric Acid in Black Africans and Its Association With Cardiovascular Risk Factors. ( Baldo, MP; Capingana, DP; Luchi, WM; Magalhães, P; Mill, JG; Moulin, SR; Souza, JB, 2017) |
| "Hyperuricemia is significantly associated with hypertension, renal dysfunction, MACE, and independently confers a higher risk of mortality in patients with AMI." | 1.46 | Association Between Hyperuricemia and Major Adverse Cardiac Events in Patients with Acute Myocardial Infarction. ( Mayise, C; Myeni, NN; Ranjith, N; Sartorius, B, 2017) |
| "Whether hyperuricemia is an independent risk factor for hypertension in adults is still under debate." | 1.46 | Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort. ( Cui, LF; Han, YX; Liu, N; Mu, R; Shi, HJ; Shu, R; Song, HC; Sun, K; Wang, GY; Wang, J; Wang, JR; Wu, SL; Yang, WH; Yu, P; Zhou, B, 2017) |
| "Hyperuricemia was defined as serum uric acid ≥416 μmol/l in men and ≥357 μmol/l in women." | 1.43 | Prevalence of hyperuricemia and its correlates in rural Northeast Chinese population: from lifestyle risk factors to metabolic comorbidities. ( Guo, X; Ou, Q; Sun, Y; Yang, H; Yu, S; Zhang, X; Zheng, L; Zhou, Y, 2016) |
| "Uric acid is a powerful determinant of blood pressure over time, independent of lifestyle modifications." | 1.43 | Increased Serum Uric Acid Levels Blunt the Antihypertensive Efficacy of Lifestyle Modifications in Children at Cardiovascular Risk. ( Antolini, L; Genovesi, S; Giussani, M; Orlando, A; Pontremoli, R; Rebora, P; Stella, A; Valsecchi, MG; Viazzi, F, 2016) |
| "Prevalence of hyperuricemia is high in patients with hypertension." | 1.43 | Hyperuricemia and Cardiovascular Disease in Patients with Hypertension. ( Acevedo, A; Benavides, J; Chowdhury, M; Lievano, M; Lombo, B; Lopez, M; Montenegro, A; Pena, L, 2016) |
| "Metabolic syndrome was defined according to the Adult Treatment Panel III criteria modified for children and adolescents." | 1.43 | Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study. ( Asayesh, H; Djalalinia, S; Eslami Shahr Babaki, A; Heshmat, R; Kelishadi, R; Motlagh, ME; Qorbani, M; Safari, O; Safiri, S; Tajadini, MH; Tajbakhsh, R, 2016) |
| "Metabolic syndrome was found in 2502 of 18,222 healthy Chinese people (16." | 1.43 | Correlation of the leucocyte count with traditional and non-traditional components of metabolic syndrome. ( Gao, BL; Su, BY; Tian, CF; Tong, YH; Zhao, XH; Zheng, Y, 2016) |
| "Hyperuricemia is an important predictor for poor prognosis in patients with LN." | 1.43 | Hyperuricemia is an independent risk factor for renal pathological damage and poor prognosis in lupus nephritis patients. ( Chen, M; Li, G; Li, J; Tang, X; Wang, X; Xie, T; Yin, H; Zhang, W; Zuo, X, 2016) |
| "In the present study, 841 NAFLD males (30-75 years) were recruited from a Chinese prospective cohort study (PMMJS) and followed up for five years." | 1.43 | Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males. ( Dong, C; Guo, Z; Liu, C; Qiu, J; Song, K; Wang, Y; Xu, Y; Zhang, B; Zhou, H; Zhou, Z, 2016) |
| "Early detection diabetic nephropathy (DN) is important." | 1.43 | Serum uric acid and its association with hypertension, early nephropathy and chronic kidney disease in type 2 diabetic patients. ( Fathy, H; Fouad, M; Zidan, A, 2016) |
| "Hyperuricemia is characterized by inhibited nitric oxide system and enhanced synthesis of reactive oxygen species." | 1.42 | Uric acid levels and the risk of Contrast Induced Nephropathy in patients undergoing coronary angiography or PCI. ( Barbieri, L; Cassetti, E; De Luca, G; Marino, P; Schaffer, A; Suryapranata, H; Verdoia, M, 2015) |
| "Hyperuricemia is an independent risk factor for hypertension." | 1.42 | Does elevated serum uric acid level predict the hypertension incidence? A Chinese prospective cohort study. ( Gao, Y; Huang, J; Li, Y; Niu, K; Sun, Y; Wan, Z; Wu, X; Yao, W; Zhang, W; Zhao, H, 2015) |
| "Systolic hypertension was detected in 0." | 1.42 | A 4-year follow-up of living unrelated donors of kidney allograft in Iran. ( Abdi, E; Broumand, B; Fazel, I; Kamgar, M; Malakoutian, T; Nobakht Haghighi, A; Radfar, M, 2015) |
| "Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee." | 1.40 | Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: a hospital based cross sectional study. ( Jha, B; Kumar, A; Poudel, B; Raut, KB; Yadav, BK, 2014) |
| "Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults." | 1.40 | Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. ( Bjornstad, P; Chonchol, MB; Jalal, D; Johnson, RJ; Maahs, DM; McFann, K; Paul Wadwa, R; Rewers, M; Rivard, CJ; Sirota, JC; Snell-Bergeon, JK, 2014) |
| "Mild hyperuricemia is a strong, independent marker of MS and high cardio-renal risk profile in hypertensive patients under specialist care." | 1.40 | Serum uric acid and its relationship with metabolic syndrome and cardiovascular risk profile in patients with hypertension: insights from the I-DEMAND study. ( Agabiti Rosei, E; Ambrosioni, E; Costa, FV; Deferrari, G; Garneri, D; Gonnella, A; Leoncini, G; Leonetti, G; Muiesan, ML; Pessina, AC; Pontremoli, R; Trimarco, B; Viazzi, F; Volpe, M, 2014) |
| "Sixty patients with type 2 diabetes mellitus were enrolled to the study." | 1.40 | Association of serum uric acid with level of blood pressure in type 2 diabetic patients. ( Behradmanesh, S; Kheiri, S; Nasri, H; Rafieian-Kopaei, M, 2014) |
| "Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg." | 1.40 | Gender difference in the association of hyperuricemia with hypertension in a middle-aged Chinese population. ( Bo, QL; Hu, AL; Hu, CQ; Liu, KY; Mu, M; Sheng, J; Shu, L; Tao, FB; Wang, S; Wang, SF; Wang, XQ; Zhao, QH, 2014) |
| "In conclusion, hyperhomocysteinemia is associated with carotid RI, a surrogate marker of cerebral vascular resistance, especially in elderly men." | 1.40 | Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males. ( Enomoto, D; Higaki, J; Irita, J; Kudo, K; Kukida, M; Miyoshi, K; Nagao, T; Okura, T; Pei, Z; Tanino, A, 2014) |
| "Uric acid (UA) is a marker of endothelial dysfunction." | 1.40 | The relationship between uric acid and erectile dysfunction in hypertensive subjects. ( Akilli, H; Alibasic, H; Aribas, A; Avci, A; Demir, K; Kanbay, M; Katlandur, H; Kaya, Z; Kayrak, M; Keser, A; Solak, Y; Turan, Y; Ulucan, S, 2014) |
| "Hypertension is a key risk factor for cardiovascular disease, and new treatments are needed." | 1.40 | Allopurinol initiation and change in blood pressure in older adults with hypertension. ( Beattie, CJ; Dawson, J; Dominiczak, AF; Fulton, RL; Higgins, P; McCallum, L; Padmanabhan, S; Touyz, RM; Walters, MR, 2014) |
| "Cardiovascular diseases are the leading cause of death for both women and men." | 1.40 | [Gender and subclinical vascular organ damage in patients with coronary artery disease and/or hypertension]. ( Lucyna, WL; Posadzy-Małaczyńska, A, 2014) |
| " There were dose-response relationships between arsenic exposure and PUA levels." | 1.40 | Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh. ( Aktar, S; Alam, S; Ali, N; Arefin, A; Aziz, A; Himeno, S; Hossain, K; Hossain, MI; Hossain, S; Huda, N; Islam, K; Karim, MR; Mamun, AA; Miyataka, H; Mohanto, NC; Rahman, M; Salam, KA; Saud, ZA, 2014) |
| "Hypertension was not independently associated with measures of nephron hypertrophy." | 1.40 | Nephron hypertrophy and glomerulosclerosis and their association with kidney function and risk factors among living kidney donors. ( Alexander, MP; Elsherbiny, HE; Kremers, WK; Lieske, JC; Park, WD; Poggio, ED; Prieto, M; Rule, AD, 2014) |
| " Dosing levels of SUA could be appropriate in the global management of patients with psoriasis, particularly in those who are obese and with serum triglycerides upper the normal range." | 1.40 | Hyperuricemia in patients with chronic plaque psoriasis. ( Gisondi, P, 2014) |
| "Nonalcoholic fatty liver disease (NAFLD) affects 9." | 1.40 | Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. ( Behling, C; Donithan, M; Hallinan, EK; Newton, KP; Schwimmer, JB; Tonascia, J; Xanthakos, SA; Zepeda, A, 2014) |
| "Uric acid levels were similar in both groups during the first half of gestation." | 1.40 | [Serum uric acid levels and risk of developing preeclampsia]. ( Balconi, SM; Corominas, AI; Damiano, AE; Maskin, B; Palermo, M, 2014) |
| "Hyperuricemia has been shown to be a strong correlate of hypertension in children." | 1.39 | Serum uric acid and blood pressure in children at cardiovascular risk. ( Antolini, L; Brambilla, P; Galbiati, S; Genovesi, S; Giussani, M; Mastriani, S; Pontremoli, R; Stella, A; Valsecchi, MG; Viazzi, F, 2013) |
| "Uric acid (UA) has shown to be a causal risk factor for the development and progression of renal disease." | 1.39 | Increased uric acid promotes decline of the renal function in hypertensive patients: a 10-year observational study. ( Kiyohara, K; Ohta, Y; Oniki, H; Tsuchihashi, T, 2013) |
| "Incident gout was defined as self-reported onset of gout after baseline." | 1.38 | Diuretic use, increased serum urate levels, and risk of incident gout in a population-based study of adults with hypertension: the Atherosclerosis Risk in Communities cohort study. ( Alonso, A; Baer, AN; Coresh, J; Gelber, AC; Maynard, JW; McAdams DeMarco, MA; Young, JH, 2012) |
| "Hyperuricemia was defined as ≥ 6." | 1.38 | Gender distribution of serum uric acid and cardiovascular risk factors: population based study. ( Baldo, MP; Capingana, P; Dantas, EM; Magalhães, P; Mill, JG; Molina, Mdel C; Morelato, RL; Rodrigues, SL; Salaroli, LB, 2012) |
| "Polytherapy was the norm for treating hypertension." | 1.38 | Plasma renin activity (PRA) levels and antihypertensive drug use in a large healthcare system. ( Bhandari, SK; Kalantar-Zadeh, K; Laragh, JH; Rasgon, SA; Sealey, JE; Shi, J; Sim, JJ, 2012) |
| "Hyperuricemia was defined as SUA ≥70 mg/L in men and ≥60 mg/L in women." | 1.38 | Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome. ( Gonçalves, JP; Lopes, C; Oliveira, A; Santos, AC; Severo, M, 2012) |
| "Hyperuricemia is an independent predictor for early atherosclerosis in hypertensive subjects with normal renal function." | 1.38 | Uric acid is an important predictor for hypertensive early atherosclerosis. ( Bahadir, E; Citil, R; Deger, SM; Durmaz, AO; Mutluay, R; Sindel, S, 2012) |
| "Uric acid (UA) has been frequently reported to be associated with MetS in the general population." | 1.38 | The relationship between serum uric acid concentration and metabolic syndrome in patients with schizophrenia or schizoaffective disorder. ( Chen, CH; Chen, PY; Chiu, CC; Huang, MC; Lu, ML; Tsai, CJ, 2012) |
| "Uric acid (UA) is a cardiovascular risk marker associated with oxidative stress and inflammation." | 1.37 | Uric acid levels and atrial fibrillation in hypertensive patients. ( Korantzopoulos, P; Li, G; Liu, T; Wang, S; Zhang, X, 2011) |
| "Gout is a common rheumatologic condition of recurrent polyarticular involvement." | 1.37 | Unknown: Multiple painful nodules - what is the diagnosis? Chronic tophaceous gout. ( Avhad, G; Dandale, A; Dhurat, R; Ghate, S, 2011) |
| "A total of 102 type 2 diabetes mellitus patients were divided into 2 groups: DR group (age, 60 +/- 6 years [mean +/- SD]; n = 31) and no diabetic retinopathy (NDR) group (59 +/- 5 years, n = 71)." | 1.36 | Diabetic retinopathy is associated with visceral fat accumulation in Japanese type 2 diabetes mellitus patients. ( Anan, F; Eshima, N; Eto, T; Ito, Y; Masaki, T; Saikawa, T; Umeno, Y; Yoshimatsu, H, 2010) |
| "The metabolic syndrome was defined based on the criteria of the Chinese Diabetes Society (CDS)." | 1.36 | The prevalence of microalbuminuria and its relationships with the components of metabolic syndrome in the general population of China. ( Chen, B; Chen, Y; Ni, Z; Xu, W; Yang, D; Ye, B, 2010) |
| "Hypertension is associated with endothelial dysfunction." | 1.36 | Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats. ( Szasz, T; Watts, SW, 2010) |
| "Although increased susceptibility to infection has been observed in subjects with diabetes or obesity, little is known about the relationship between metabolic disorders and increased susceptibility to infection." | 1.36 | Association between capacity of interferon-alpha production and metabolic parameters. ( Fukui, M; Hasegawa, G; Nakamura, N; Nakumura, N; Tominaga, M; Uno, K; Yagi, K; Yoshikawa, T, 2010) |
| "Uric acid was significantly associated with increased likelihood for diastolic HTN (OR = 2." | 1.35 | Serum uric acid and ambulatory blood pressure in children with primary hypertension. ( Alpert, BS; Jones, DP; Li, R; Richey, PA, 2008) |
| "Hypertension was prevented by olmesartan, but not by allopurinol." | 1.35 | Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor. ( Kasal, DA; Mandarim-de-Lacerda, CA; Neves, MF; Oigman, W, 2008) |
| "Hyperuricemia is significantly predicted by anthropometric measure of SFT which is a simple clinical screening method along with creatinine levels." | 1.35 | Hyperuricemia and its related factors in an urban population, Izmir, Turkey. ( Akar, S; Akkoc, N; Birlik, M; Gurler, O; Onen, F; Pakoz, B; Sari, I; Sisman, AR, 2009) |
| "Losartan is an antihypertensive drug with all these capabilities and placebo-like side-effect profile." | 1.35 | [The pleiotropic effects of losartan--the importance of decreasing uric acid level]. ( Cseh, J; Csiky, B; Markó, L; Mikolás, E; Mohás, M; Szíjártó, I; Wittmann, I, 2008) |
| "Hyperuricemia is a common finding in hypertensive patients, especially among those who are on diuretic therapy." | 1.35 | Uric acid as a marker for renal dysfunction in hypertensive women on diuretic and nondiuretic therapy. ( Batista, MC; Borges, RL; Hirota, AH; Quinto, BM; Ribeiro, AB; Zanella, MT, 2009) |
| "Uric acid was significantly correlated with hsCRP (r = 0." | 1.35 | Uric acid is an independent predictor of arterial stiffness in hypertensive patients. ( Chen, JH; Chen, JY; Huang, YY; Lee, CH; Li, WT; Lin, CC; Tsai, WC, 2009) |
| "In conclusion, hyperuricemia is associated with hypertension in a Chinese population at a high risk of hypertension." | 1.35 | Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension. ( Li, L; Lu, H; Lu, ZH; Lu, ZS; Wang, JA; Yan, SG; You, W, 2009) |
| "The prevalence of hyperuricemia is low in Uygurs, who have a high prevalence of cardiovascular risk factors such as hypertension, overweight-obesity, dyslipidemia, hyperglycemia, and insulin resistance (IR)." | 1.35 | Serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population. ( Hong, J; Li, NF; Wang, HM; Yang, J; Yao, XG; Zhou, L, 2009) |
| "Moreover, hyperuricemia is significantly correlated with hypertriglyceridemia, hypertension, and visceral obesity." | 1.35 | Serum uric acid levels and risk of metabolic syndrome in healthy adults. ( Bandarian, F; Ebrahimpour, P; Fakhrzadeh, H; Heshmat, R; Larijani, B, 2008) |
| "Hypertension is an independent risk factor for peripheral arterial disease." | 1.34 | Prevalence of and risk factors for peripheral arterial disease in the patients with hypertension among Han Chinese. ( Hui, R; Sun, K; Wu, H; Yang, X; Zhang, H; Zhang, W, 2007) |
| "Hyperuricemia is associated with hypertension, vascular disease and cardiovascular (CV) disease." | 1.34 | Association between serum uric acid levels and coronary flow reserve in hypertensive patients without concomitant risk factors. ( Caliskan, M; Erdogan, D; Gullu, H; Muderrisoglu, H; Ozer, I; Yildirim, I; Yildirir, A, 2007) |
| "Moreover, according to the presence of left ventricular hypertrophy (LVH) the participants were subdivided into two additional groups: [LVH (+), n=305 and LVH (-), n=537]." | 1.33 | The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage. ( Antoniadis, D; Chatzis, D; Dimitriadis, K; Kallikazaros, I; Lalos, S; Stefanadis, C; Toutouzas, P; Tsioufis, C; Vezali, E; Zervoudaki, A, 2005) |
| "Metabolic syndrome is associated with subclinical organ damage in nondiabetic, essential hypertensive patients." | 1.33 | Metabolic syndrome is associated with early signs of organ damage in nondiabetic, hypertensive patients. ( Deferrari, G; Falqui, V; Leoncini, G; Parodi, A; Parodi, D; Pontremoli, R; Ratto, E; Tomolillo, C; Vaccaro, V; Viazzi, F, 2005) |
| "Hypertension is a multi-factorial process, prevalent in developed as well as in developing countries." | 1.33 | Different antioxidants status, total antioxidant power and free radicals in essential hypertension. ( Jain, S; Kashyap, MK; Khullar, M; Kumari, S; Nath, R; Sharma, PC; Sherawat, BS; Yadav, V, 2005) |
| "Hyperuricemia and gout have shown an increase worldwide." | 1.33 | The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China. ( Dong, Y; Gao, W; Nan, H; Qian, R; Qiao, Q; Tang, B; Tuomilehto, J, 2006) |
| "The pathogenesis of nephrolithiasis in Cushing's syndrome is still not completely clarified." | 1.32 | Nephrolithiasis in Cushing's disease: prevalence, etiopathogenesis, and modification after disease cure. ( Colao, A; Di Somma, C; Faggiano, A; Filippella, M; Lombardi, G; Melis, D; Petretta, M; Pivonello, R, 2003) |
| "Exercise-induced acute renal failure (ARF) developed in a 45-year-old man during antihypertensive therapy with losartan and trichlormethiazide." | 1.32 | A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide. ( Hasegawa, Y; Ito, O; Ito, S; Kudo, K; Mitsui, H; Sato, H; Sato, K; Yuda, F, 2003) |
| "Since hyperuricemia is associated with obesity, renal disease, hyperlipidemia, and atherosclerosis, whether or not serum urate is a cardiovascular risk factor per se has remained elusive." | 1.32 | Leptin might be a regulator of serum uric acid concentrations in humans. ( Alvur, M; Arik, N; Bedir, A; Tanyeri, F; Topbas, M, 2003) |
| "Fifteen patients with untreated arterial hypertension were enrolled." | 1.32 | Effect of cilazapril with or without low dose thiazide on LDL peroxidation in [correction of peroxidationin] hypertensive patients. ( Hussein, O; Radan, A; Reuven, V, 2003) |
| "Obesity was significantly associated with a history of diabetes mellitus (18 vs." | 1.32 | Prevalence of obesity in an elderly Hungarian population. ( Antal, M; Donáth, J; Gergely, P; Kiss, C; Paksy, A; Poór, G; Zajkás, G, 2003) |
| "Underexcretory hyperuricemia is strongly related to hypertensive organ damage and this relationship does not seem to be mediated by a decreased renal function." | 1.32 | Hyperuricemia, low urine urate excretion and target organ damage in arterial hypertension. ( Campo, C; Garcia-Puig, J; García-Robles, R; Rodicio, JL; Ruilope, LM; Segura, J, 2003) |
| "Women with chronic hypertension are at increased risk for superimposed preeclampsia." | 1.32 | A prediction model for superimposed preeclampsia in women with chronic hypertension during pregnancy. ( August, P; Cook, EF; Helseth, G; Sison, C, 2004) |
| "Hypertension was the most common followed infrequency by dyslipidemia, diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease consecutively." | 1.32 | Clinical manifestations of patients with hyperuricemia. ( Akkasilpa, S; Avihingsanon, Y; Hanvivadhanakul, P; Wonchinsri, J, 2004) |
| "Hyperuricemia is associated with renal disease, but it is usually considered a marker of renal dysfunction rather than a risk factor for progression." | 1.31 | A role for uric acid in the progression of renal disease. ( Feng, L; Han, L; Harris, R; Johnson, RJ; Kang, DH; Mazzali, M; Nakagawa, T; Truong, L; Watanabe, S, 2002) |
| "To know the prevalence of phenotypic dyslipidemias and their clinical and metabolic characteristics in recently diagnosed hypertensive patients." | 1.31 | [Prevalence of dyslipidemia and its phenotypes in recently diagnosed essential arterial hypertension]. ( García-Morillo, S; Miranda, ML; Montilla, C; Pamies, E; Stiefel, P; Villar, J, 2000) |
| "Etiology of preeclampsia is still largely unraveled and treatment is syndrome specific." | 1.31 | [Twin pregnancy and preeclampsia]. ( Leszczyńska-Gorzelak, B; Oleszczuk, JJ; Szymczyk, G, 2000) |
| "Malignant hypertension is a serious form of arterial hypertension in which the physiopathological mechanisms include increased activity of the sympathetic nervous system, renin angiotensin system, and endothelium dysfunction." | 1.31 | Hemodynamic and metabolic profile in offspring of malignant hypertensive parents. ( Bortolotto, LA; Kamitsuji, CS; Krieger, EM; Lopes, HF; Szlejf, C, 2001) |
| "In conclusion, hyperinsulinemia, as well as obesity, hyperuricemia, and hypertriglyceridemia were associated with hypertension in Japanese-Americans." | 1.31 | Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study. ( Egusa, G; Imazu, M; Kohno, N; Okubo, M; Sumii, K; Toyofuku, M; Yamakido, M; Yamamoto, H, 2001) |
| "While obesity was not associated with microalbuminuria once central adiposity was taken into account, elevated percent body fat remained associated with microalbuminuria." | 1.31 | Microalbuminuria, central adiposity and hypertension in the non-diabetic urban population of the MONICA Augsburg survey 1994/95. ( Döring, A; Hense, HW; Keil, U; Liese, AD; Stieber, J, 2001) |
| "Hydrochlorothiazide treatment did not prevent the hyperuricemia or arteriolopathy despite controlling blood pressure." | 1.31 | Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. ( Chen, Q; Feng, L; Gordon, KL; Han, L; Johnson, RJ; Kanellis, J; Kang, DH; Lan, HY; Mazzali, M; Nakagawa, T; Watanabe, S; Xia, YY, 2002) |
| "L-Carnitine treatment for 6 weeks lowered significantly both the systolic and mean arterial pressure of SHR but its influence on diastolic and pulse pressure was only modest." | 1.30 | The effect of chronic L-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats. ( Dobesová, Z; Drahota, Z; Kunes, J; Rauchová, H; Zicha, J, 1998) |
| "Diabetes Mellitus was defined as fasting blood glucose over 110 mg/dl, or the initiation of diabetic therapy." | 1.30 | Health risk assessment for diabetes mellitus based on longitudinal analysis of MHTS database. ( Hinohara, S; Izuno, T; Miyakawa, M; Nakamura, K; Sugimori, H; Takahashi, E; Tanaka, C; Yoshida, K, 1998) |
| "Insulin resistance was estimated by homeostasis model assessment (HOMA(IR)), preliminarily validated against a euglycemic-hyperinsulinemic clamp in 85 subjects." | 1.30 | Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. ( Alberiche, M; Bonadonna, RC; Bonora, E; Egger, G; Kiechl, S; Muggeo, M; Oberhollenzer, F; Targher, G; Willeit, J, 1998) |
| "Class 3 HELLP syndrome is considered a clinically significant transitional group." | 1.30 | The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification. ( Blake, PG; Magann, EF; Martin, JN; May, WL; Rinehart, BK; Terrone, DA, 1999) |
| "The insulin resistance is associated with a clustering of risk factors of cardiovascular disease, more cluste-ring, more resistant." | 1.30 | [The role of insulin resistance in the clustering of cardiovascular risk factors]. ( Guo, D; Xu, C, 1997) |
| "In conclusion, the data suggest that NIDDM, hypertension, tallness, obesity, high insulin and low HDL cholesterol levels constitute risk factors for the development of BPH." | 1.30 | Clinical, anthropometric, metabolic and insulin profile of men with fast annual growth rates of benign prostatic hyperplasia. ( Hammarsten, J; Högstedt, B, 1999) |
| "13 patients had combination of hyperinsulinemia with obesity, dyslipidemia, arterial hypertension." | 1.30 | [Urate affection of kidneys and metabolic disturbances in hypertensive patients]. ( Anikina, SA; Balkarov, IM; Donskov, AS; Fadina, ZM; Feofanova, ID; Golub', GV; Goncharov, VS; Saltykova, NG, 1999) |
| "Hypertension is associated with an increased risk of atherosclerosis." | 1.29 | Antioxidant status in controlled and uncontrolled hypertension and its relationship to endothelial damage. ( Blann, A; Holder, R; Maxwell, SR; Thomason, H; Thorpe, GH; Tse, WY; Waite, M, 1994) |
| "From these data it emerges that hyperaldosteronism, as observed in these patients with CRI, is a relatively reliable marker of the extent of CRI and may occur independently of the activation of the RAA system, given that other factors, such as orthostatic stimulation, alterations in the acid-base equilibrium, and the degree of aldosterone hepatic and urinary clearance, contribute to its pathogenesis." | 1.29 | [Role of aldosterone in essential arterial hypertension complicated by chronic renal insufficiency]. ( Buracchi, P; Carletti, F; Gennari, C; Lucani, B; Martinelli, M; Nami, R; Panza, F; Pavese, G; Saia, F, 1993) |
| "In all cases the diagnosis of aortic dissection was confirmed by at least two different imaging methods (ultrasonography, digital subtractional angiography, computer tomography or nuclear magnetic resonance)." | 1.29 | Results of long-term medical treatment of patients with arterial hypertension complicated by aortic dissection. ( Brocki, Z; Cieśliński, A; Grajek, S; Lehman, Z; Mitkowski, P; Ochotny, R; Paradowski, S; Pawlak, B; Ponizyński, A, 1995) |
| "Epidemiologically, diabetes mellitus affects men by 64% and women by 36%." | 1.29 | [Diabetes mellitus at the National Hospital Center of Ouagadougou (Burkina Faso)]. ( Drabo, PY; Ilboudo, PD; Kabore, J; Lengani, A, 1996) |
| "Hydrochlorothiazide was discontinued if the diastolic blood pressure remained less than or equal to 94 mm Hg after a 6-month period on the lower dose of hydrochlorothiazide." | 1.28 | Effects of reduction in dose and discontinuation of hydrochlorothiazide in patients with controlled essential hypertension. ( Kochar, MS; Landry, KM; Ristow, SM, 1990) |
| " This study describes the observed adverse reactions in this group of patients not undergoing transplantation." | 1.27 | Side effects of systemic cyclosporine in patients not undergoing transplantation. ( Chan, CC; Nussenblatt, RB; Palestine, AG, 1984) |
| "Chlorthalidone therapy was discontinued in 36 of the 67 patients." | 1.27 | Step-down treatment of mild systemic hypertension. ( Finnerty, FA, 1984) |
| " Results suggest that very-low-calorie diets can be an effective and safe means of substantial weight reduction." | 1.27 | Safety and effectiveness of weight reduction using a very-low-calorie formulated food. ( Budell, W; Clements, M; Kreitzman, SN; Krissman, P; Nichols, D; Pedersen, M, 1984) |
| "The diagnosis coronary heart disease is based on the ECG at rest (Minnesota-code), in 796 test persons an exercise electrocardiogram was made." | 1.27 | [The value of hypertension and metabolic factors on the development of coronary heart disease in type II diabetic patients]. ( Hanefeld, M; Julius, U; Lippold, C; Schmechel, H; Schulze, J; Schwanebeck, U, 1988) |
| "Cigarette smoking, hypertension, dyslipidemia, heredity, diabetes mellitus, obesity, beta blockades, and coronary artery bypass surgery are some of the topics discussed." | 1.27 | Preventive cardiology for coronary artery disease. ( Miller, WW, 1985) |
| "163 patients suffering from sudden hearing loss were examined with regard to their cardiovascular risk factors (hypertension, hyperlipaemia, cigarette smoking, hyperglycaemia, hyperuricaemia and obesity)." | 1.27 | [Etiology and pathogenesis of sudden deafness]. ( Friedrich, G, 1985) |
| "The birth weight was superior to 2500 g in 51 children, including 37 who weighed more than 3000 g." | 1.26 | [Treatment of hypertension in pregnant women with beta-blockers. 60 cases (author's transl)]. ( Dubois, D; Klepper, A; Petitcolas, J; Temperville, B, 1980) |
| "This is a report of 3 patients with cerebral infarct in whom a silent recent myocardial infarction was found." | 1.26 | Coincidence of cerebrovascular accident and silent myocardial infarction. ( Badui, E; Estañol, B; Garcia-Rubi, D, 1982) |
| " A twice-daily regimen was considerably more effective than a single morning dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency." | 1.26 | Controlled inpatient study of tienilic acid in treatment of gout and hypertension. ( Reardon, JA; Scott, JT, 1980) |
| "10 patients with severe preeclampsia showed changes in both coagulation and renal function when compared with 13 normotensive controls." | 1.26 | Clinical relevance of coagulation and renal changes in pre-eclampsia. ( Dunlop, W; Hill, LM; Jones, P; Landon, MJ; Oxley, A, 1978) |
| "Type V hyperlipemia is not very common." | 1.26 | [Type V hyperlipemia. 54 cases (author's transl)]. ( Beaumont, V; Buxtorf, JC; Jacotot, B; Schlesinger, M, 1979) |
| "Hypertension was found in 18% of 65 patients with untreated gout, a lower prevalence than that previously reported." | 1.26 | Hypertension, renal function and gout. ( Gibson, T; Highton, J; Potter, CF; Simmonds, HA, 1979) |
| " Their long term use alone provides smooth control of blood pressure in mild to moderate hypertensives (Beevers, Hamilton and Harpur, 1971), and they are also valuable as adjuvant therapy with other antihypertensive drugs." | 1.26 | The effect of thiazide diuretics on coronary risk factors. ( Beevers, DG; Bloxham, CA, 1979) |
| "Ticrynafen is an orally administered diuretic that is similar to the thiazides in its therapeutic actions, but unlike the thiazides, it increases urate excretion and lowers serum uric acid levels." | 1.26 | Evaluation of a new uricosuric diuretic--ticrynafen. ( Kosman, ME, 1979) |
| " The mean resting blood pressures were 168/108 mmHg, 151/98 mmHg and 150/96 mmHg at pre-trial, after the twice-daily dosage period and after the once-daily dosage period, respectively." | 1.26 | A fixed combination of metoprolol and hydrochlorothiazide for hypertension: a multi-centre study. ( Goodfellow, RM, 1979) |
| " -- The potassium loss is variable according to dosage (maximum at 500 mg), renal function (low when reduced)." | 1.26 | [Thienylic acid, a new drug with saluretic and uricosuric activity. Preliminary data]. ( Borghetti, A; Borghi, L; Guariglia, A; Minari, M; Novarini, A; Peracchi, R, 1978) |
| "Both renal calculi and tophi are frequent in female gout associated with blood dyscrasias." | 1.26 | Some unusual features of gouty arthritis in females. ( Yü, TF, 1977) |
| "Xipamide was given in combination with clonidine hydrochloride." | 1.26 | Studies covering combined treatments with xipamide. Results of a long-term antihypertensive treatment. ( Heimsoth, VH, 1977) |
| "Obesity was found in 19 per cent of all patients and serum uric acid levels over 0." | 1.25 | Myocardial infarction in young men. Study of risk factors in nine countries. ( Dolder, MA; Oliver, MF, 1975) |
| "A nearly 72-old black male with sickle cell anemia suffered from heart failure, hypertension, chronic impaired kidney function with hyperuricemia and gout." | 1.25 | Long survival in sickle cell anemia. ( Huisman, TH; Sar, AV, 1975) |
| "Generalized osteoarthrosis was found to be significantly more common in older males with high than with low diastolic blood pressure." | 1.25 | Hypertension in relation to musculoskeletal disorders. ( Lawrence, JS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 711 (37.17) | 18.7374 |
| 1990's | 191 (9.98) | 18.2507 |
| 2000's | 270 (14.11) | 29.6817 |
| 2010's | 524 (27.39) | 24.3611 |
| 2020's | 217 (11.34) | 2.80 |
| Authors | Studies |
|---|---|
| Buzas, R | 2 |
| Ivan, VS | 1 |
| Gheorghe-Fronea, OF | 1 |
| Morgovan, AF | 1 |
| Ardelean, M | 1 |
| Albulescu, N | 1 |
| Dorobantu, M | 2 |
| Lighezan, DF | 1 |
| Xiong, Y | 1 |
| Wangsheng, F | 1 |
| Wang, S | 6 |
| Zhou, W | 4 |
| Huang, X | 3 |
| Bao, H | 4 |
| Cheng, X | 5 |
| Yu, C | 4 |
| Ren, X | 1 |
| Pan, L | 2 |
| Zhao, H | 4 |
| Wang, Y | 24 |
| Chang, L | 2 |
| He, H | 2 |
| Xi, J | 1 |
| Shan, G | 2 |
| Masajtis-Zagajewska, A | 2 |
| Majer, J | 2 |
| Nowicki, M | 4 |
| Silva, NR | 1 |
| Gonçalves, CET | 1 |
| Gonçalves, DLN | 1 |
| Cotta, RMM | 1 |
| da Silva, LS | 1 |
| Carvalho, JF | 1 |
| Shoenfeld, Y | 2 |
| Tikhonoff, V | 9 |
| Casiglia, E | 11 |
| Spinella, P | 1 |
| Barbagallo, CM | 7 |
| Bombelli, M | 13 |
| Cicero, AFG | 11 |
| Cirillo, M | 8 |
| Cirillo, P | 8 |
| Desideri, G | 7 |
| D'elia, L | 8 |
| Ferri, C | 8 |
| Galletti, F | 9 |
| Gesualdo, L | 6 |
| Giannattasio, C | 10 |
| Iaccarino, G | 7 |
| Mallamaci, F | 9 |
| Maloberti, A | 12 |
| Masi, S | 7 |
| Mazza, A | 9 |
| Muiesan, ML | 8 |
| Nazzaro, P | 7 |
| Palatini, P | 9 |
| Parati, G | 11 |
| Pontremoli, R | 19 |
| Quarti-Trevano, F | 6 |
| Rattazzi, M | 7 |
| Rivasi, G | 7 |
| Salvetti, M | 7 |
| Tocci, G | 7 |
| Ungar, A | 7 |
| Verdecchia, P | 11 |
| Viazzi, F | 19 |
| Virdis, A | 8 |
| Volpe, M | 9 |
| Grassi, G | 19 |
| Borghi, C | 21 |
| Cao, Z | 2 |
| Dai, S | 1 |
| Liu, X | 4 |
| Dong, J | 5 |
| Yang, H | 8 |
| Zhang, Y | 20 |
| Hu, Q | 1 |
| Bezerra, TTD | 1 |
| Bezerra, LS | 1 |
| Santos-Veloso, MAO | 1 |
| Lordsleem, ABMDS | 1 |
| Lima, SG | 1 |
| Zhang, D | 6 |
| Huang, QF | 3 |
| Sheng, CS | 2 |
| Li, Y | 17 |
| Wang, JG | 6 |
| Lee, J | 3 |
| Choi, J | 1 |
| Yum, Y | 1 |
| Joo, HJ | 1 |
| Kim, YH | 2 |
| An, H | 1 |
| Kim, EJ | 2 |
| Mou, AD | 3 |
| Barman, Z | 3 |
| Hasan, M | 3 |
| Miah, R | 3 |
| Hafsa, JM | 1 |
| Das Trisha, A | 1 |
| Ali, N | 5 |
| Lai, YJ | 1 |
| Chen, YY | 2 |
| Ku, PW | 2 |
| Chen, LJ | 1 |
| Yen, YF | 1 |
| Xu, X | 8 |
| Huang, J | 3 |
| Wu, S | 4 |
| Ji, Q | 1 |
| Guo, X | 8 |
| Huang, Y | 4 |
| Kawazoe, M | 1 |
| Funakoshi, S | 1 |
| Ishida, S | 1 |
| Yoshimura, C | 1 |
| Satoh, A | 2 |
| Maeda, T | 1 |
| Tsuji, M | 1 |
| Yokota, S | 1 |
| Tada, K | 1 |
| Takahashi, K | 4 |
| Ito, K | 2 |
| Yasuno, T | 1 |
| Fujii, H | 1 |
| Okutsu, S | 1 |
| Mukobara, S | 1 |
| Kawanami, D | 1 |
| Nabeshima, S | 1 |
| Kondo, S | 1 |
| Masutani, K | 1 |
| Arima, H | 4 |
| Kimura, Y | 1 |
| Tsukui, D | 1 |
| Kono, H | 2 |
| Mori, K | 2 |
| Furuhashi, M | 2 |
| Tanaka, M | 4 |
| Higashiura, Y | 2 |
| Koyama, M | 2 |
| Hanawa, N | 1 |
| Ohnishi, H | 2 |
| Sun, J | 1 |
| Sun, M | 3 |
| Su, Y | 2 |
| Li, M | 4 |
| Ma, S | 2 |
| Zhang, A | 1 |
| Cai, S | 1 |
| Cheng, B | 1 |
| Bao, Q | 1 |
| Zhu, P | 3 |
| Feitosa, RS | 1 |
| Martins, BP | 1 |
| Almeida, LM | 1 |
| de Oliveira, MB | 1 |
| de Araújo, RMS | 1 |
| de Oliveira, KA | 1 |
| Nie, FQ | 1 |
| Huang, XB | 1 |
| Tang, W | 1 |
| Hu, R | 1 |
| Zhang, WQ | 1 |
| Liu, JX | 1 |
| Xu, RH | 1 |
| Liu, Y | 5 |
| Wei, D | 1 |
| Wang, TD | 1 |
| Fan, X | 1 |
| Du, J | 1 |
| Jin, Y | 2 |
| Jia, P | 1 |
| Zhang, S | 3 |
| Song, B | 1 |
| Yu, H | 1 |
| Zhang, X | 11 |
| Shao, Y | 1 |
| Chen, Y | 8 |
| Yang, Y | 6 |
| Zhong, Y | 2 |
| Li, J | 16 |
| Kong, T | 1 |
| Yang, S | 1 |
| Wu, C | 1 |
| Cui, B | 1 |
| Fu, L | 1 |
| Hui, R | 4 |
| Zhang, W | 7 |
| Koto, R | 2 |
| Sato, I | 2 |
| Kuwabara, M | 12 |
| Seki, T | 2 |
| Kawakami, K | 2 |
| Vanoli, J | 2 |
| Facchetti, R | 7 |
| Mancia, G | 11 |
| Wang, W | 3 |
| Wang, Q | 1 |
| Yang, N | 3 |
| Gruszka, K | 2 |
| Drożdż, T | 2 |
| Wojciechowska, W | 2 |
| Jankowski, P | 1 |
| Terlecki, M | 1 |
| Bijak, M | 1 |
| Hering, D | 1 |
| Bilo, G | 1 |
| Drożdż, D | 1 |
| Rajzer, M | 2 |
| Aktas, G | 1 |
| Khalid, A | 1 |
| Kurtkulagi, O | 1 |
| Duman, TT | 1 |
| Bilgin, S | 1 |
| Kahveci, G | 1 |
| Atak Tel, BM | 1 |
| Sincer, I | 1 |
| Gunes, Y | 1 |
| Angeli, F | 4 |
| Reboldi, G | 6 |
| Kametas, NA | 1 |
| Nzelu, D | 1 |
| Nicolaides, KH | 1 |
| Hong, X | 2 |
| Xie, M | 1 |
| Dong, Y | 3 |
| Zou, Z | 1 |
| Zheng, C | 1 |
| Reichetzeder, C | 1 |
| Krämer, BK | 2 |
| Lv, Y | 1 |
| Hocher, B | 1 |
| Zhuang, H | 1 |
| Lin, Z | 1 |
| Zeng, S | 1 |
| Jiang, M | 2 |
| Chen, L | 3 |
| Jiang, X | 2 |
| Xu, Y | 3 |
| Ohamadike, O | 1 |
| Lim, SL | 1 |
| Siegel, A | 1 |
| Zemtsov, G | 1 |
| Kuller, JA | 1 |
| Dotters-Katz, S | 1 |
| Choy, SH | 1 |
| Nyanatay, SA | 1 |
| Sothilingam, S | 1 |
| Malek, R | 1 |
| J R, S | 1 |
| Toh, CC | 1 |
| Sundram, M | 1 |
| Md Yusoff, NA | 1 |
| Nagappan, P | 1 |
| Kamaruzaman, S | 1 |
| Yeoh, WS | 1 |
| Ong, TA | 1 |
| Lim, J | 1 |
| Bc, PK | 1 |
| Somannavar, VG | 1 |
| Fritz, J | 1 |
| Brozek, W | 1 |
| Concin, H | 1 |
| Nagel, G | 1 |
| Kerschbaum, J | 1 |
| Lhotta, K | 1 |
| Ulmer, H | 1 |
| Zitt, E | 1 |
| Theofilis, P | 2 |
| Tsimihodimos, V | 3 |
| Vordoni, A | 2 |
| Kalaitzidis, RG | 2 |
| Laso García, I | 1 |
| Gomez Dos Santos, V | 1 |
| Sánchez Herranz, A | 1 |
| Duque Ruiz, G | 1 |
| Arias Fúnez, F | 1 |
| Hevia Palacios, M | 1 |
| Burgos Revilla, FJ | 1 |
| Sandoval-Plata, G | 2 |
| Morgan, K | 2 |
| Abhishek, A | 2 |
| Zuo, C | 1 |
| Li, X | 11 |
| Fan, L | 2 |
| Tian, D | 1 |
| Chen, C | 5 |
| Lv, Q | 1 |
| Agnoletti, D | 1 |
| Lurbe, E | 2 |
| Humbert, X | 1 |
| Licaj, I | 1 |
| Fedrizzi, S | 1 |
| Alexandre, J | 1 |
| Menotti, A | 2 |
| Manrique, A | 1 |
| Allouche, S | 1 |
| Touzé, E | 1 |
| Terradura-Vagnarelli, O | 1 |
| Puddu, PE | 1 |
| Vallée, A | 1 |
| Rahman, MM | 2 |
| Kamrul-Hasan, AB | 1 |
| Jasmine, T | 1 |
| Hossain, MS | 1 |
| Saha, PK | 1 |
| Sarker, MA | 1 |
| Luo, Q | 3 |
| Qin, L | 1 |
| Yang, X | 5 |
| Wang, H | 11 |
| Akari, S | 2 |
| Nakamura, T | 3 |
| Furusawa, K | 1 |
| Miyazaki, Y | 2 |
| Kario, K | 6 |
| Liu, P | 1 |
| Yin, C | 2 |
| Liu, M | 7 |
| Wu, T | 1 |
| Li, Z | 2 |
| Luo, R | 1 |
| Du, X | 1 |
| Zhao, W | 2 |
| Xian, W | 1 |
| Wu, D | 1 |
| Huo, Z | 1 |
| Hong, S | 1 |
| Xiao, H | 3 |
| Polito, L | 3 |
| Bortolotti, M | 2 |
| Battelli, MG | 3 |
| Bolognesi, A | 3 |
| Louca, P | 1 |
| Tran, TQB | 1 |
| Toit, CD | 1 |
| Christofidou, P | 1 |
| Spector, TD | 1 |
| Mangino, M | 1 |
| Suhre, K | 1 |
| Padmanabhan, S | 3 |
| Menni, C | 1 |
| Meremo, A | 1 |
| Paget, G | 1 |
| Duarte, R | 1 |
| Dickens, C | 1 |
| Dix-Peek, T | 1 |
| Bintabara, D | 1 |
| Naicker, S | 1 |
| Ding, N | 1 |
| He, L | 1 |
| Li, C | 4 |
| Yazdi, F | 2 |
| Shakibi, MR | 1 |
| Baniasad, A | 1 |
| Najafzadeh, MJ | 1 |
| Najafipour, H | 1 |
| Sistani, S | 1 |
| Wei, R | 1 |
| Xie, J | 1 |
| Meng, F | 1 |
| He, F | 1 |
| Liu, J | 4 |
| Zhao, Y | 1 |
| Liang, H | 1 |
| Hu, LK | 1 |
| Lu, YK | 1 |
| Liu, YH | 1 |
| Chu, X | 1 |
| Yan, YX | 1 |
| Lüscher, BP | 3 |
| Schoeberlein, A | 3 |
| Surbek, DV | 3 |
| Baumann, MU | 3 |
| Zhao, G | 4 |
| Guo, D | 4 |
| Li, L | 10 |
| Yang, C | 4 |
| Dell'Oro, R | 5 |
| Lippa, L | 5 |
| Masulli, M | 3 |
| Mengozzi, A | 3 |
| An, Y | 2 |
| Ouyang, F | 2 |
| Xiao, S | 2 |
| Fariha, KA | 2 |
| Sony, SA | 2 |
| Ahmed, S | 2 |
| Hasan, A | 2 |
| Mohanto, NC | 3 |
| Gor, Z | 1 |
| Bezen, D | 1 |
| Turkmenoglu, Y | 1 |
| Vurgun, E | 1 |
| Irdem, A | 1 |
| Dursun, H | 1 |
| Finotto, A | 1 |
| Redon, P | 2 |
| Wang, J | 7 |
| Geng, Y | 1 |
| Zhou, M | 1 |
| Yin, X | 2 |
| Ping, Z | 1 |
| Shang, Y | 1 |
| Sinitsina, II | 1 |
| Boyarko, AV | 1 |
| Temirbulatov, II | 1 |
| Sychev, DA | 1 |
| Akmalova, KA | 1 |
| Sozaeva, ZA | 1 |
| Grishina, EA | 1 |
| Mirzaev, KB | 1 |
| Asoskova, AV | 1 |
| Fisenko, VP | 1 |
| Liu, H | 4 |
| Song, X | 3 |
| Zhu, J | 3 |
| Wang, T | 3 |
| Zhu, L | 4 |
| Shen, L | 3 |
| Zhou, Z | 2 |
| Zhang, J | 12 |
| Shih, YL | 1 |
| Shih, CC | 1 |
| Chen, SY | 2 |
| Chen, JY | 3 |
| Zhong, D | 1 |
| Liu, D | 1 |
| Guo, Y | 3 |
| Huang, H | 3 |
| Wu, F | 2 |
| Huang, S | 2 |
| Wang, XQ | 2 |
| Tan, JS | 1 |
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| Chrysant, SG | 5 |
| Chou, H | 2 |
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| Chen, H | 5 |
| Shi, L | 2 |
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| Fukuda, H | 3 |
| Sato, Y | 4 |
| Hisaoka, T | 2 |
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| Zhang, M | 6 |
| Lekpa, FK | 1 |
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| Reubi, F | 1 |
| Jouve, A | 1 |
| Sommer, A | 1 |
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| Fondarai, J | 1 |
| Carmena, R | 1 |
| Doran, TA | 1 |
| Benzie, RJ | 1 |
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| Porter, CJ | 1 |
| Thompson, DW | 1 |
| Liedgren, SI | 1 |
| Perez-Stable, EC | 1 |
| Ryckewaert, A | 6 |
| Kuntz, D | 1 |
| Macrez, C | 1 |
| Lescure, J | 1 |
| Cottier, P | 1 |
| Lindheimer, MD | 3 |
| Katz, AI | 2 |
| Holmes, EW | 1 |
| Wessels, F | 2 |
| Heinze, A | 1 |
| Oberwittler, W | 1 |
| Duriez, R | 1 |
| Halpert, J | 1 |
| Bressac, F | 1 |
| Laurens, A | 1 |
| Casanova, B | 1 |
| Ribot, C | 1 |
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| Bertrand, E | 1 |
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| Hvidt, R | 1 |
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| Lund-Sorensen, J | 1 |
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| Tibblin, G | 1 |
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| Lindeman, RD | 2 |
| Spiekerman, RE | 1 |
| Berge, KG | 1 |
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| Knapp, E | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Losartan and Eprosartan Induce a Similar Effect on Oral Fructose-induced Rise in Serum Uric Acid Concentration in Patients With Metabolic Syndrome[NCT04954560] | 16 participants (Actual) | Interventional | 2008-01-01 | Completed | |||
| Losartan and Uric Acid Metabolism in Children With Proteinuric Nephropathies: a Cross-over Randomized Clinical Trail[NCT05402397] | Phase 4 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Effect of the Interaction Between Environmental Factors and Genetic Predisposition on Long-term Blood Pressure in Chinese Population[NCT02734472] | 5,298 participants (Anticipated) | Observational | 2016-07-31 | Recruiting | |||
| A Multi-center, Double-blind, Double-dummy, Randomized, Placebo- and Active-reference, Parallel Group, Phase 2, Dose-finding Study With ACT-132577 in Subjects With Essential Hypertension (Grade 1 and 2).[NCT02603809] | Phase 2 | 1,659 participants (Actual) | Interventional | 2015-12-14 | Completed | ||
| Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage[NCT04752293] | 125 participants (Anticipated) | Observational | 2021-05-19 | Recruiting | |||
| [NCT00000544] | Phase 3 | 0 participants | Interventional | 1993-08-31 | Completed | ||
| The Dose-response Effect of Serum Uric Acid on the Prevalence and Electrocardiographic Left Ventricular Hypertrophy in the Apparently Healthy Individuals[NCT03473951] | 18,000 participants (Anticipated) | Observational | 2018-03-26 | Recruiting | |||
| University of Alabama at Birmingham CORT Project 2: The Effects of Urate Lowing Therapy (ULT) in Inflammation, Endothelial Function, and Blood Pressure[NCT02038179] | Phase 2/Phase 3 | 99 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Non-Invasive HaemoDYNAMICs in Primary and Secondary Hypertension: the DYNAMIC-study[NCT01742702] | 2,000 participants (Anticipated) | Observational | 2006-05-25 | Recruiting | |||
| Chronobiology and Chronopharmacology to Prevent Sickle Cell Kidney Disease[NCT02373241] | Phase 2 | 1 participants (Actual) | Interventional | 2015-04-30 | Terminated (stopped due to Estimated GFR was determined not to be a reliable endpoint for this study. We identified significant variabilty in annual eGFR that it became inappropriate to randomize to a medication but use EGFR as the primary endpoint.) | ||
| African American Study of Kidney Disease and Hypertension ABPM Pilot Study[NCT00582777] | Phase 2/Phase 3 | 180 participants (Anticipated) | Interventional | 2007-11-30 | Completed | ||
| A Phase 2, Double-Blind, Placebo-Controlled Study to Assess the Effect of Febuxostat 80 mg Once Daily Compared to Placebo on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension[NCT01496469] | Phase 2 | 121 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Five Plus Nuts and Beans Trial[NCT01689844] | 123 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| A Randomised Double-blind Cross-over Single-centre Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension[NCT03276598] | Phase 4 | 233 participants (Actual) | Interventional | 1999-11-25 | Completed | ||
| A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients With Left Ventricular Hypertrophy[NCT00338260] | Phase 3 | 496 participants (Actual) | Interventional | 1995-06-30 | Completed | ||
| Registro Campania Salute Network for the Treatment of Hypertension and Correlated Diseases[NCT02211365] | 10,000 participants (Anticipated) | Observational [Patient Registry] | 2014-02-28 | Recruiting | |||
| A Phase 3, Randomized, Double Blind, Multicenter, Placebo Controlled Study to Evaluate the Efficacy and Safety of Febuxostat 40 mg XR, 80 mg XR, 40 mg IR and 80 mg IR in Subjects With Gout[NCT02139046] | Phase 3 | 1,790 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial[NCT00081328] | Phase 3 | 699 participants (Actual) | Interventional | 2004-05-31 | Completed | ||
| Randomized, Multicenter, Double-blind, Placebo-controlled Efficacy and Safety Study of 8 mg PEG-uricase in Two Dose Regimens in Hyperuricemic Subjects With Symptomatic Gout[NCT00325195] | Phase 3 | 225 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| Central and Peripheral Blood Pressure and Its Relation With Vascular Target Organ Damage in Carotid, Retinal and Arterial Stiffness. Developed and Validation of a Tool[NCT01325064] | 500 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Paediatric Obesity and Cardiovascular Dysfunction: Searching for Early Markers of Damage[NCT03169257] | 100 participants (Actual) | Interventional | 2015-01-15 | Completed | |||
| The Effect of Acute Fructose Load in Patients With Chronic Kidney Disease and Patients With Type 2 Diabetes Compared to Healthy Subjects[NCT03157960] | 20 participants (Actual) | Interventional | 2012-02-01 | Completed | |||
| Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933] | Phase 2 | 34 participants (Actual) | Interventional | 2019-06-18 | Completed | ||
| Effect of Dapagliflozin on Nighttime Blood Pressure in Type 2 Diabetes[NCT03887416] | Phase 4 | 225 participants (Anticipated) | Interventional | 2019-04-12 | Recruiting | ||
| A Comparison of the Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels on Liver and Muscle Fatty Infiltration, Insulin Resistance, Glucose, Insulin, Leptin, Ghrelin, Postprandial Triglycerides[NCT01797042] | 366 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Value of Uric Acid as Early Predictor of Lupus Nephritis in Assiut University Hospital[NCT05402735] | 100 participants (Anticipated) | Observational | 2022-06-15 | Recruiting | |||
| Genetic, Environment and Its Interaction Analysis for Cardiovascular Autonomic Neuropathy in Chinese Population[NCT02461342] | 2,100 participants (Actual) | Observational | 2011-01-31 | Completed | |||
| The Risk Analysis for Cardiovascular Autonomic Neuropathy in General Chinese Population[NCT02462616] | 2,100 participants (Actual) | Observational | 2011-01-31 | Completed | |||
| Study on the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention[NCT03425708] | Phase 4 | 400 participants (Anticipated) | Interventional | 2017-01-01 | Recruiting | ||
| A Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes[NCT02887677] | Phase 4 | 85 participants (Actual) | Interventional | 2016-10-31 | Terminated (stopped due to On February 2019 Astra-Zeneca Greece decided to stop the financial support of the study.) | ||
| [NCT00000608] | Phase 2 | 0 participants | Interventional | 1997-02-28 | Completed | ||
| Comparison of Serum Concentrations, Physical and Psychological Well-being in Patients Having Chronic Musculoskeletal Pain With and Without Metabolic Syndrome[NCT03338868] | 100 participants (Anticipated) | Observational [Patient Registry] | 2015-08-01 | Recruiting | |||
| Randomized Double-blinded, Placebo-controlled, Cross-over Trial of Allopurinol for the Treatment of Newly Diagnosed Essential Hypertension in Adolescents[NCT00288184] | Phase 2 | 30 participants (Actual) | Interventional | 2004-09-30 | Completed | ||
| Pediatric Hypertension Registry (PHREG)[NCT03305562] | 179 participants (Actual) | Observational [Patient Registry] | 2017-09-20 | Terminated (stopped due to Study was a pilot study and the investigators received funding to initiate the main study) | |||
| The Role of the Renin-Angiotensin System in Pediatric Primary Hypertension (PHRAS)[NCT03310684] | 160 participants (Anticipated) | Observational | 2018-12-03 | Active, not recruiting | |||
| [NCT02797028] | Phase 4 | 320 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | ||
| Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept[NCT04012294] | Phase 3 | 200 participants (Anticipated) | Interventional | 2019-08-30 | Recruiting | ||
| Phase 2 Study to Determine if Allopurinol Blocks Features of Metabolic Syndrome Induced by Fructose Ingestion[NCT00639756] | Phase 2 | 60 participants (Anticipated) | Interventional | 2008-06-30 | Completed | ||
| Novel Methods for Ascertainment of Gout Flares -A Pilot Study[NCT02855437] | 44 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| A Phase 3, Randomized, Multicenter, Double-Blind, Allopurinol-Controlled Study Assessing the Efficacy and Safety of Oral Febuxostat in Subjects With Gout.[NCT00430248] | Phase 3 | 2,269 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Alkaline Diet for Insulin Sensitivity[NCT02501343] | 32 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Renal Protective Effects of Losartan in Patients With Non-insulin Dependent Diabetes Mellitus and Nephropathy[NCT00308347] | Phase 3 | 1,513 participants (Actual) | Interventional | 1996-05-31 | Completed | ||
| Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)[NCT00246519] | Phase 4 | 1,701 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| Efficacy and Safety of Two Fixed-combination Antihypertensive Regimens, Amtrel® and Co-Diovan® in Type 2 Diabetes Hypertension Patients With Microalbuminuria[NCT01375322] | Phase 4 | 226 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial[NCT04587544] | 76 participants (Actual) | Interventional | 2019-07-01 | Completed | |||
| Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)[NCT03317925] | 29 participants (Actual) | Observational | 2014-07-16 | Completed | |||
| Study Protocol for a Prospective Observational Study Investigating the Role of Luminal Pressure on Arteriovenous Fistula Maturation[NCT04017806] | 60 participants (Anticipated) | Observational | 2018-09-19 | Recruiting | |||
| The Relationship Between Uric Acid and Inflammatory Markers[NCT01323335] | Phase 1 | 97 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| The Bogalusa Heart Study[NCT00005129] | 11,737 participants (Actual) | Observational | 1972-06-30 | Active, not recruiting | |||
| The Clinical Utility of the Congo-Red Dot Test for Diagnosis and Early Prediction of Preeclampsia During Pregnancy[NCT02455544] | 346 participants (Actual) | Observational [Patient Registry] | 2014-08-31 | Completed | |||
| Glucose Optimisation With Angiotensin II Antagonist Losartan in Patients With Hypertension and Other Risk Factors for Metabolic Syndrome (GOAAL)[NCT00237588] | Phase 4 | 25 participants | Interventional | 2004-12-31 | Completed | ||
| Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive Patients[NCT04554069] | 280 participants (Anticipated) | Observational | 2021-06-01 | Not yet recruiting | |||
| Uric Acid and Hypertension in African Americans[NCT00241839] | Phase 3 | 150 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| A Randomized, Placebo-Controlled, Double-Blind, Parallel Study of the Anti-Hypertensive Efficacy and Safety of Losartan Monotherapy as Compared to HCTZ Monotherapy and to the Combination of Losartan and HCTZ in Japanese Patients With Essential Hypertensio[NCT00092209] | Phase 3 | 840 participants | Interventional | 2002-04-30 | Completed | ||
| Influence of Food Liking of Adding Spices to Replace Dietary Sugar Using Sequential Monadic CLT Methodology[NCT03139552] | 150 participants (Actual) | Interventional | 2016-10-17 | Completed | |||
| Influence on Food Liking of Adding Spices to Replace Dietary Sugar[NCT03134079] | 160 participants (Actual) | Interventional | 2015-09-10 | Completed | |||
| Prospective, Randomized, Open-Label Study in Patients With Mild-to-Moderate Essential Hypertension to Compare the Antihypertensive Efficacy Determined by Ambulatory Blood Pressure Monitoring of Valsartan and Enalapril After Missing One Dose[NCT00302705] | Phase 4 | 150 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761] | Phase 4 | 471 participants (Actual) | Interventional | 2018-02-13 | Completed | ||
| [NCT00000482] | Phase 3 | 0 participants | Interventional | 1965-04-30 | Completed | ||
| [NCT00005140] | 0 participants | Observational | 1977-09-30 | Completed | |||
| Randomized Controlled Trial for Postpartum Antihypertensive Treatment of Women With Preeclampsia[NCT04298034] | Phase 3 | 300 participants (Anticipated) | Interventional | 2020-07-17 | Recruiting | ||
| [NCT00000514] | Phase 3 | 0 participants | Interventional | 1984-06-30 | Completed | ||
| Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504] | Phase 4 | 25 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Omentectomy for Treatment of Diabetes Mellitus Type 2[NCT00270439] | Phase 1 | 10 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Phase 4 Study of the Effects of Pravastatin on Cholesterol Levels, Inflammation and Cognition in Schizophrenia[NCT01082588] | Phase 4 | 60 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Effects of Fenofibrate on Metabolic and Reproductive Parameters in Polycystic Ovary Syndrome. A Randomized, Double-Blind, Placebo-Controlled Trial[NCT00884819] | 4 participants (Actual) | Interventional | 2008-12-31 | Terminated (stopped due to Poor recruitment) | |||
| Randomized Controlled Trial of N-acetylcysteine and Acetazolamide in Treatment of Chronic Mountain Sickness[NCT01187108] | Phase 1/Phase 2 | 85 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Addressing HyperteNsion and Diabetes Through Community-Engaged Systems in Puno, Peru (ANDES Study)[NCT05524987] | 1,068 participants (Anticipated) | Interventional | 2022-11-30 | Not yet recruiting | |||
| [NCT00005123] | 0 participants | Observational | 1965-07-31 | Completed | |||
| [NCT00000522] | Phase 2 | 0 participants | Interventional | 1985-08-31 | Completed | ||
| [NCT00005232] | 0 participants | Observational | 1988-08-31 | Completed | |||
| [NCT00005186] | 0 participants | Observational | 1986-04-30 | Completed | |||
| [NCT00000485] | Phase 3 | 0 participants | Interventional | 1971-05-31 | Completed | ||
| Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care[NCT05698680] | Phase 4 | 314 participants (Anticipated) | Interventional | 2023-01-18 | Recruiting | ||
| [NCT00000487] | Phase 3 | 0 participants | Interventional | 1972-06-30 | Completed | ||
| [NCT00005122] | 0 participants | Observational | 1958-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Ratio of group mean at trough to group mean at peak was calculated from the diastolic ambulatory blood pressure monitoring performed over a 24-hour period with the ABPM device. The trough (the smallest blood pressure reduction) and the peak (the highest blood pressure reduction) ratio show the extent of blood pressure lowering throughout the 24-hour dosing interval in the group.~The group mean trough (at 20-24 hours) to group mean (at 2-6 hours) peak of diastolic blood pressure were examined to evaluate the extent to which once-daily dosing criteria were met (trough-to-peak values greater than 0.5).~The ratio is positive if there was a decrease in diastolic blood pressure at both the trough and peak times at the end of treatment (Day 55 to Day 56) when compared to baseline (Day -1 to Day 1).~For ambulatory blood pressure monitoring the baseline was the period from the time of last run-in placebo intake up to the time of the first double-blind treatment intake." (NCT02603809)
Timeframe: Baseline (Day -1 to Day 1) and end of double-blind treatment (Day 55 and Day 56)
| Intervention | Ratio of mean at trough to mean at peak (Number) |
|---|---|
| Placebo | -48.03 |
| Aprocitentan 5 mg | 2.59 |
| Aprocitentan 10 mg | 0.90 |
| Aprocitentan 25 mg | 1.49 |
| Aprocitentan 50 mg | 1.25 |
| Lisinopril 20 mg | 0.65 |
"Participants had their blood pressure measured at the study site using the BpTRU® device. The BpTRU® is an automatic unattended office blood pressure measurement device. Six measurements, at rest, per participant per visit were performed. The mean of the last 5 measurements was used for the analysis.~A participant was a responder if the reduction from baseline in mean trough sitting diastolic blood pressure (SiDBP) was 10 mmHg or greater-than 10 mmHg." (NCT02603809)
Timeframe: Baseline (Day 1) and end of double-blind treatment (Day 56)
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 21 |
| Aprocitentan 5 mg | 21 |
| Aprocitentan 10 mg | 34 |
| Aprocitentan 25 mg | 40 |
| Aprocitentan 50 mg | 38 |
| Lisinopril 20 mg | 31 |
"Participants had their blood pressure measured at the study site using the BpTRU® device. The BpTRU® is an automatic unattended office blood pressure measurement device. Six measurements, at rest, per participant per visit were performed. The mean of the last 5 measurements was used for the analysis.~A participant was a responder if the reduction from baseline in mean trough sitting systolic blood pressure (SiSBP) was 20 mmHg or greater-than 20 mmHg." (NCT02603809)
Timeframe: Baseline (Day 1) and end of double-blind treatment (Day 56)
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 16 |
| Aprocitentan 5 mg | 16 |
| Aprocitentan 10 mg | 22 |
| Aprocitentan 25 mg | 28 |
| Aprocitentan 50 mg | 22 |
| Lisinopril 20 mg | 20 |
"Diastolic and systolic ambulatory blood pressure monitoring was performed over a 24-hour period with the ABPM device (Mobil-o-Graph) set to record diastolic and systolic blood pressure at a pre-defined time. Over a 24-hour period 3 measurements per hour during the day and 2 per hour during the night were made. The blood pressure measurements were derived from the area under the diastolic and systolic blood pressure curves and divided by the time span and averaged.~For ambulatory blood pressure monitoring the baseline was the period from the time of last run-in placebo intake up to the time of the first double-blind treatment intake." (NCT02603809)
Timeframe: Baseline (Day -1 to Day 1) and end of double-blind treatment (Day 55 and Day 56)
| Intervention | mmHg (Mean) | |||
|---|---|---|---|---|
| Baseline 24-hour mean DBP | Absolute change in 24-hour mean DBP at Week 8 | Baseline 24-hour mean SBP | Absolute change in 24-hour mean SBP at Week 8 | |
| Aprocitentan 10 mg | 92.60 | -6.55 | 144.30 | -7.72 |
| Aprocitentan 25 mg | 89.28 | -8.86 | 140.83 | -9.23 |
| Aprocitentan 5 mg | 90.60 | -3.76 | 139.90 | -3.16 |
| Aprocitentan 50 mg | 91.53 | -5.98 | 141.28 | -6.07 |
| Lisinopril 20 mg | 91.18 | -5.72 | 143.35 | -7.23 |
| Placebo | 90.46 | -2.49 | 140.28 | -3.54 |
"Participants had their blood pressure measured at the study site using the BpTRU® device. The BpTRU® is an automatic unattended office blood pressure measurement device. Six measurements, at rest, per participant per visit were performed. The mean of the last 5 measurements was used for the analysis.~The absolute change in mean trough sitting diastolic blood pressure (SiDBP) measured by from baseline (i.e., at randomization) to week 8 (Day 56). A negative change indicates a decrease in the diastolic blood pressure from the start of treatment." (NCT02603809)
Timeframe: Baseline (Day 1) and end of double-blind treatment (Day 56)
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline | Absolute Change from Baseline to Week 8 | |
| Aprocitentan 10 mg | 97.7 | -9.9 |
| Aprocitentan 25 mg | 97.8 | -12.0 |
| Aprocitentan 5 mg | 97.8 | -6.3 |
| Aprocitentan 50 mg | 98.2 | -10.0 |
| Lisinopril 20 mg | 96.8 | -8.4 |
| Placebo | 97.5 | -4.9 |
"Participants had their blood pressure measured at the study site using the BpTRU® device. The BpTRU® is an automatic unattended office blood pressure measurement device. Six measurements, at rest, per participant per visit were performed. The mean of the last 5 measurements was used for the analysis.~The absolute change in mean trough sitting systolic blood pressure (SiSBP) measured by from baseline (i.e., at randomization) to week 8 (Day 56). A negative change indicates a decrease in the systolic blood pressure from the start of treatment." (NCT02603809)
Timeframe: Baseline (Day 1) and end of double-blind treatment (Day 56)
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline | Absolute Change from Baseline to Week 8 | |
| Aprocitentan 10 mg | 149.8 | -15.0 |
| Aprocitentan 25 mg | 151.2 | -18.5 |
| Aprocitentan 5 mg | 149.4 | -10.3 |
| Aprocitentan 50 mg | 148.6 | -15.1 |
| Lisinopril 20 mg | 149.8 | -12.8 |
| Placebo | 149.2 | -7.7 |
"Participants had their blood pressure measured at the study site using the BpTRU® device. The BpTRU® is an automatic unattended office blood pressure measurement device. Six measurements, at rest, per participant per visit were performed. The mean of the last 5 measurements was used for the analysis. The Canadian Hypertension Education Program (CHEP) issued guidelines proposing cut-offs of 85 mmHg for diastolic blood pressure and 135 mmHg for systolic blood pressure specifically focusing on measurement by automated office blood pressure measurement. The number of participants at the end of the 8-week treatment period that had values below the protocol and CHEP cut-off values are reported.~The initial protocol control rates at Week 8 (Day 56) on trough SiDBP are also reported and were defined as a SiDBP of less than 90 mmHg and a SiSBP of less than 140 mmHg." (NCT02603809)
Timeframe: End of double-blind treatment (Day 56)
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| SiDBP less than 90 mmHg | SiDBP less than 85 mmHg (CHEP) | SiSBP less than 140 mmHg | SiSBP less than 135 mmHg (CHEP) | |
| Aprocitentan 10 mg | 37 | 29 | 43 | 32 |
| Aprocitentan 25 mg | 43 | 29 | 44 | 38 |
| Aprocitentan 5 mg | 30 | 15 | 37 | 27 |
| Aprocitentan 50 mg | 39 | 21 | 47 | 36 |
| Lisinopril 20 mg | 38 | 23 | 39 | 31 |
| Placebo | 22 | 17 | 34 | 24 |
"Participants had their blood pressure measured at the study site using the BpTRU® device. The BpTRU® is an automatic unattended office blood pressure measurement device. Six measurements, at rest, per participant per visit were performed. The mean of the last 5 measurements was used for the analysis.~The absolute change in mean trough sitting diastolic blood pressure (SiDBP) measured by from baseline (i.e., at randomization) to week 8 (Day 56). A negative change indicates a decrease in the diastolic blood pressure from the start of treatment." (NCT02603809)
Timeframe: Baseline (Day -1 to Day 1) and end of double-blind treatment (Day 55 and Day 56)
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline | Absolute Change from Baseline to Week 8 | |
| Aprocitentan 10 mg | 97.7 | -9.9 |
| Aprocitentan 25 mg | 98.2 | -11.7 |
| Aprocitentan 5 mg | 97.5 | -5.8 |
| Aprocitentan 50 mg | 98.4 | -9.9 |
| Lisinopril 20 mg | 96.9 | -8.2 |
| Placebo | 98.0 | -4.2 |
Compare endothelial function as indexed by flow-mediated arterial vasodilation (FMD) within each phase of treatment (allopurinol 300 mg/day PO or placebo). Percent (%) change in FMD is calculated by comparing FMD (%) at the end of each treatment phase to pre-treatment values. (NCT02038179)
Timeframe: 4 weeks (pre-treatment vs. post-treatment FMD Values (%))
| Intervention | percent change (Mean) |
|---|---|
| Allopurinol Phase | 2.5 |
| Placebo Phase | -0.1 |
Serum level of high sensitivity C-reactive protein will be reported as a change during treatment phase (allopurinol 300 mg/day PO or placebo). Change in serum level of C-reactive protein is calculated by comparing serum values at the end of each treatment phase to pre-treatment levels. (NCT02038179)
Timeframe: 4 weeks (pre-treatment vs. post-treatment serum levels)
| Intervention | mg/L (Mean) |
|---|---|
| Allopurinol Phase | 0.6 |
| Placebo Phase | 0.8 |
Compare systolic blood pressure (SBP) captured by wearing a 24 hour ambulatory blood pressure monitor during each phase of treatment (allopurinol 300 mg/day PO or placebo). Change in systolic blood pressure is calculated by comparing SBP at the end of each treatment phase to pre-treatment values. (NCT02038179)
Timeframe: 4 weeks (pre-treatment vs. post-treatment SBP)
| Intervention | mm Hg (Mean) |
|---|---|
| Allopurinol Phase | -1.39 |
| Placebo Phase | -1.06 |
"Outcome 1a. Document the rate of acceptance (quantitative) and reasons for acceptance/rejection (qualitative) in a randomized trial of trial of losartan for SCD patients with abnormal nocturnal blood pressures.~Outcome 1b. Identify the adherence rate to losartan during a randomized three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure.~Outcome 1c. Determine the adherence rate to study procedures among participants enrolled in a three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure." (NCT02373241)
Timeframe: 5 yrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard Blood Pressure Management | 0 |
| Experimental Blood Pressure Management | 1 |
As a feasibility trial, the effect of losartan on lowering nocturnal hypertension will be monitored to identify the difference in nocturnal BP improvement between the two treatment arms, and within group standard deviation of BP (NCT02373241)
Timeframe: 5 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental Blood Pressure Management | 1 |
We will prospectively evaluate the incidence of hypertension (Clinic BP in pts >5yrs and ABPM in pts >10 yrs) and role of blood and urine biomarkers (pts >5ys) among participants with HbSS or SB0 thalassemia (expected cohort n=200) over 5 yrs. We identified 20 participants (34%) with incident hypertension but randomized one to the study. The study was terminated as the eGFR was determined not to be a reliable endpoint in pediatric sickle cell. (NCT02373241)
Timeframe: 5 yrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard Blood Pressure Management | 0 |
| Experimental Blood Pressure Management | 1 |
The change in 24-hour mean DBP measured at final visit or Week 6 relative to baseline. Ambulatory blood pressure monitoring measures blood pressure at regular intervals throughout the day and night. The 24-hour mean is the average of all measurements recorded for 24 hours after dosing. (NCT01496469)
Timeframe: Baseline and Week 6
| Intervention | mmHg (Least Squares Mean) | |
|---|---|---|
| Baseline | Change at Week 6 | |
| Febuxostat 80 mg | 83.0 | -2.0 |
| Placebo | 85.9 | -2.7 |
The change in 24-hour mean SBP measured at final visit or Week 6 relative to baseline. Ambulatory blood pressure monitoring measures blood pressure at regular intervals throughout the day and night. The 24-hour mean is the average of all measurements recorded for 24 hours after dosing. (NCT01496469)
Timeframe: Baseline and Week 6
| Intervention | millimeters of mercury (mmHg) (Least Squares Mean) | |
|---|---|---|
| Baseline | Change at Week 6 | |
| Febuxostat 80 mg | 139.5 | -3.7 |
| Placebo | 142.3 | -3.4 |
(NCT01496469)
Timeframe: Baseline and Week 6
| Intervention | mg/dL (Least Squares Mean) | |
|---|---|---|
| Baseline | Change at Week 6 | |
| Febuxostat 80 mg | 7.6 | -3.3 |
| Placebo | 7.7 | 0.1 |
"A participant was considered to have a gout flare if the following criteria were met:~Participant-reported acute particular pain typical of a gout attack that was deemed by participant and/or investigator to require treatment and was treated with colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids, Participant experienced at least 3 or more of: 1) Joint swelling, 2) Redness, 3) Tenderness, 4) Pain, Participant experienced at least one or more of: 1) Rapid onset of pain, 2) Decreased range of motion, 3) Joint warmth, 4) Other symptoms similar to a prior gout flare." (NCT02139046)
Timeframe: Baseline to Month 3
| Intervention | percentage of participants (Number) |
|---|---|
| Placebo | 20.7 |
| Febuxostat IR 40 mg | 21.0 |
| Febuxostat XR 40 mg | 22.8 |
| Febuxostat IR 80 mg | 27.2 |
| Febuxostat XR 80 mg | 26.6 |
(NCT02139046)
Timeframe: Month 3
| Intervention | percentage of participants (Number) |
|---|---|
| Placebo | 0.3 |
| Febuxostat IR 40 mg | 15.7 |
| Febuxostat XR 40 mg | 25.9 |
| Febuxostat IR 80 mg | 42.6 |
| Febuxostat XR 80 mg | 50.1 |
(NCT02139046)
Timeframe: Month 3
| Intervention | percentage of participants (Number) |
|---|---|
| Placebo | 0.6 |
| Febuxostat IR 40 mg | 40.3 |
| Febuxostat XR 40 mg | 48.2 |
| Febuxostat IR 80 mg | 57.7 |
| Febuxostat XR 80 mg | 61.1 |
Body mass index (BMI) measured in kg per meters squared. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | kg per meters squared (Mean) |
|---|---|
| 1 Metformin Alone | 36.7 |
| 2 Metformin + Rosliglitazone | 38.2 |
| 3 Metformin + Lifestyle Program | 35.3 |
Measured by DXA, both whole body scan and AP-spine scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months
| Intervention | g/cm squared (Mean) |
|---|---|
| 1 Metformin Alone | 1.15 |
| 2 Metformin + Rosliglitazone | 1.15 |
| 3 Metformin + Lifestyle Program | 1.15 |
Determined by DXA whole body scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months
| Intervention | kg (Mean) |
|---|---|
| 1 Metformin Alone | 36.1 |
| 2 Metformin + Rosliglitazone | 39.7 |
| 3 Metformin + Lifestyle Program | 32.2 |
Waist circumference (cm) measured at the iliac crest at its outermost point with the measuring tape placed around the participant in a horizontal plane parallel to the floor at the mark and the measurement teken at the end of normal expiration without the tape compressing the skin. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | cm (Mean) |
|---|---|
| 1 Metformin Alone | 110.8 |
| 2 Metformin + Rosliglitazone | 114.0 |
| 3 Metformin + Lifestyle Program | 108.6 |
A diagnosis was made by an out-of-range value >=95th percentile or systolic >=130 or diastolic >=80 sustained over 6 months or on an anti-hypertensive medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 57 |
| 2 Metformin + Rosliglitazone | 53 |
| 3 Metformin + Lifestyle Program | 45 |
A diagnosis was made from out-of-range value >= 130 mg/dL sustained over 6 months or put on lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 18 |
| 2 Metformin + Rosliglitazone | 16 |
| 3 Metformin + Lifestyle Program | 15 |
A diagnosis was made by an out-of-range value >=150 mg/dL sustained over 6 months or on appropriate lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 20 |
| 2 Metformin + Rosliglitazone | 28 |
| 3 Metformin + Lifestyle Program | 22 |
Insulinogenic index determined from OGTT as difference in insulin at 30 minutes minus 0 minutes divided by difference in glucose at 30 minutes minus 0 minutes. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | uU/mL divided by mg/dL (Median) |
|---|---|
| 1 Metformin Alone | .75 |
| 2 Metformin + Rosliglitazone | .83 |
| 3 Metformin + Lifestyle Program | .71 |
All participants were followed to 24 months. Insulin sensitivity is measured from OGTT as inverse of fasting insulin (mL/uU). The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | mL/uU (Median) |
|---|---|
| 1 Metformin Alone | 0.037 |
| 2 Metformin + Rosiglitazone | 0.049 |
| 3 Metformin + Lifestyle Program | 0.039 |
Number of serious adverse events reported during the trial. Participant could have multiple episodes reported. (NCT00081328)
Timeframe: Reported as occurred during study follow-up - 2 years to 6.5 years from randomization.
| Intervention | episodes of serious adverse event (Number) |
|---|---|
| 1 Metformin Alone | 42 |
| 2 Metformin + Rosiglitazone | 34 |
| 3 Metformin + Lifestyle Program | 58 |
Defined as A1c persistently >=8% over a 6-month period or persistent metabolic decompensation (inability to wean insulin within 3 months of initiation or the occurrence of a second episode within three months of discontinuing insulin) (NCT00081328)
Timeframe: Study duration - 2 years to 6.5 years of follow up from randomization
| Intervention | participants (Number) | |
|---|---|---|
| Treatment failure | Did not fail treatment during trial | |
| 1 Metformin Alone | 120 | 112 |
| 2 Metformin + Rosliglitazone | 90 | 143 |
| 3 Metformin + Lifestyle Program | 109 | 125 |
Change from Baseline to Month 6 (or last observation carried forward)in number of swollen joints per subject. Values were inputed using last observation carried forward analysis for subjects who did not complete the studies. (NCT00325195)
Timeframe: Baseline and Final Visit (Month 6 or LOCF)
| Intervention | Swollen joints (Mean) |
|---|---|
| q2 Wks | -5.5 |
| q4 Wks | -5.1 |
| Placebo | -2.6 |
Change from Baseline to Month 6 (or last observation carried forward) in number of tender joints per participant (NCT00325195)
Timeframe: Baseline and Final Visit (Month 6 or LOCF)
| Intervention | Tender joints (Mean) |
|---|---|
| q2 Wks | -7.4 |
| q4 Wks | -6.1 |
| Placebo | -1.2 |
PUA Responder was defined as a participant who achieved and maintained plasma uric acid concentrations < 6 mg/dL for at least 80% of the time during months 3 and 6 combined. Participants who withdrew from the study before month 6 were considered non-responders. (NCT00325195)
Timeframe: Months 3 and 6
| Intervention | Participants (Number) |
|---|---|
| q2 Wks | 36 |
| q4 Wks | 29 |
| Placebo | 0 |
percentage of tophaceous subjects who demonstrated a complete resolution (100 % decrease in measured area or complete disappearance)of at least one tophus in the absence of other tophus progression or new tophi, as assessed by a blinded Central Reader using standardized digital photographs and image analysis software. (NCT00325195)
Timeframe: Baseline and Final Visit (6 months or LOCF)
| Intervention | Percent subjects with resolved tophus (Number) |
|---|---|
| q2 Wks | 40 |
| q4 Wks | 21 |
| Placebo | 7 |
Health Assessment Questionnaire(HAQ: VAS pain scale where 0 (no pain)-100 (severe pain); HAQ disability index (HAQ-DI) on a scale from 0(no disability) to 3 (completely disabled), and a unit change of > or =0.22 is considerd a mimimal clinically important difference(MCID). SF-36 Physical Component Summary Score (SF36-PCS), a composite score where 0 is the worst score and 100 the best possible, and where a change of > or =2.5 units in the PCS is considered a MCID. (NCT00325195)
Timeframe: Baseline to Final Visit (Month 6 or LOCF)
| Intervention | Units on a scale (Mean) | ||
|---|---|---|---|
| HAQ-VAS Pain | HAQ-DI | SF-36 PCS | |
| Placebo | 1.4 | 0.0 | -0.3 |
| q2 Wks | -11.4 | -0.22 | 4.4 |
| q4 Wks | -6.9 | -0.20 | 4.9 |
Percent of participants reporting a gout flare during Months 1-3 and Months 4-6. Denominator during the respective period was based upon number of participants during that period. (NCT00325195)
Timeframe: Months 1-3 and Months 4-6
| Intervention | Percent subjects reporting flares (Number) | |
|---|---|---|
| Months 1-3 | Months 4-6 | |
| Placebo | 54 | 67 |
| q2 Wks | 75 | 41 |
| q4 Wks | 81 | 56 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -3.4 |
| Treatment Grup | -13.5 |
Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.15 |
| Treatment Grup | 2.55 |
Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of ECW/TBW (Mean) |
|---|---|
| Placebo | -0.24 |
| Treatment Grup | -2.92 |
decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -5.4 |
| Treatment Grup | -18.1 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -10 |
| Treatment Grup | -26.1 |
Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of sodium excreted (Mean) |
|---|---|
| Placebo | -0.348 |
| Treatment Grup | 0.598 |
Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.075 |
| Treatment Grup | -4.36 |
Feasibility ----Assessed by the percentage of participants completing answer IRV/RheumPRO queries. (NCT02855437)
Timeframe: 6 months
| Intervention | percentage of weekly response (Mean) |
|---|---|
| Interactive Voice Response | 81 |
| RheumPro Smartphone Application | 80 |
Percentage of total study population preferring IVR vs. RheumPRO (NCT02855437)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Interactive Voice Response | 3 |
| RheumPro Smartphone Application | 28 |
The percent change in serum urate from baseline to the Final visit was summarized. The final visit was the last visit at which a serum urate value was collected. (NCT00430248)
Timeframe: Baseline and Last Visit on treatment (up to 6 months)
| Intervention | percent change from baseline (Mean) |
|---|---|
| Febuxostat 40 mg QD | -33.1 |
| Febuxostat 80 mg QD | -40.6 |
| Allopurinol 200 mg or 300 mg QD | -31.3 |
Serum urate values were obtained at the Month 2 visit. The percent change in serum urate from baseline to the Month 2 visit was summarized. (NCT00430248)
Timeframe: Baseline and Month 2
| Intervention | percent change from baseline (Mean) |
|---|---|
| Febuxostat 40 mg QD | -35.1 |
| Febuxostat 80 mg QD | -44.5 |
| Allopurinol 200 mg or 300 mg QD | -33.8 |
Serum urate values were obtained at the Month 4 visit. The percent change in serum urate from baseline to the Month 4 visit was summarized. (NCT00430248)
Timeframe: Baseline and Month 4
| Intervention | percent change from baseline (Mean) |
|---|---|
| Febuxostat 40 mg QD | -34.9 |
| Febuxostat 80 mg QD | -45.5 |
| Allopurinol 200 mg or 300 mg QD | -34.5 |
Serum urate values were obtained at the Month 6 visit. The percent change in serum urate from baseline to the Month 6 visit was summarized. (NCT00430248)
Timeframe: Baseline and Month 6
| Intervention | percent change from baseline (Mean) |
|---|---|
| Febuxostat 40 mg QD | -35.6 |
| Febuxostat 80 mg QD | -45.1 |
| Allopurinol 200 mg or 300 mg QD | -34.4 |
The percentage of subjects with mild-to-moderate renal impairment whose serum urate was <6.0 mg/dL at the final visit was summarized. The final visit was the last visit at which a serum urate value was collected. (NCT00430248)
Timeframe: Last Visit on treatment (up to 6 months)
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 49.7 |
| Febuxostat 80 mg QD | 71.6 |
| Allopurinol 200 mg or 300 mg QD | 42.3 |
The percentage of subjects whose serum urate level was <6.0 mg/dL at the Final Visit was summarized. The Final Visit was the last visit at which a serum urate value was collected. (NCT00430248)
Timeframe: Last Visit on treatment (up to 6 months)
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 45.2 |
| Febuxostat 80 mg QD | 67.1 |
| Allopurinol 200 mg or 300 mg QD | 42.1 |
The percentage of subjects whose serum urate level was <4.0 mg/dL at the Final Visit was summarized. The Final Visit was the last visit at which a serum urate values was collected. (NCT00430248)
Timeframe: Last Visit on treatment (up to 6 months)
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 2.5 |
| Febuxostat 80 mg QD | 17.5 |
| Allopurinol 200 mg or 300 mg QD | 1.5 |
Serum urate values were obtained at the Month 2 visit. The percentage of subjects whose serum urate was <4.0 mg/dL at the Month 2 visit was summarized. (NCT00430248)
Timeframe: Month 2
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 2.1 |
| Febuxostat 80 mg QD | 17.5 |
| Allopurinol 200 mg or 300 mg QD | 1.5 |
Serum urate values were obtained at the Month 4 visit. The percentage of subjects whose serum urate was <4.0 mg/dL at the Month 4 visit was summarized. (NCT00430248)
Timeframe: Month 4
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 2.0 |
| Febuxostat 80 mg QD | 18.6 |
| Allopurinol 200 mg or 300 mg QD | 1.4 |
Serum urate values were obtained at the Month 6 visit. The percentage of subjects whose serum urate was <4.0 mg/dL at the Month 6 visit was summarized. (NCT00430248)
Timeframe: Month 6
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 3.1 |
| Febuxostat 80 mg QD | 20.3 |
| Allopurinol 200 mg or 300 mg QD | 1.8 |
The percentage of subjects whose serum urate level was <5.0 mg/dL at the Final Visit was summarized. The Final Visit was the last visit at which a serum urate values was collected. (NCT00430248)
Timeframe: Last Visit on treatment (up to 6 months)
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 16.5 |
| Febuxostat 80 mg QD | 44.0 |
| Allopurinol 200 mg or 300 mg QD | 13.2 |
Serum urate values were obtained at the Month 2 visit. The percentage of subjects whose serum urate was <5.0 mg/dL at the Month 2 visit was summarized. (NCT00430248)
Timeframe: Month 2
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 15.4 |
| Febuxostat 80 mg QD | 45.9 |
| Allopurinol 200 mg or 300 mg QD | 11.7 |
Serum urate values were obtained at the Month 4 visit. The percentage of subjects whose serum urate was <5.0 mg/dL at the Month 4 visit was summarized. (NCT00430248)
Timeframe: Month 4
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 15.0 |
| Febuxostat 80 mg QD | 51.6 |
| Allopurinol 200 mg or 300 mg QD | 13.5 |
Serum urate values were obtained at the Month 6 visit. The percentage of subjects whose serum urate was <5.0 mg/dL at the Month 6 visit was summarized. (NCT00430248)
Timeframe: Month 6
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 19.3 |
| Febuxostat 80 mg QD | 49.7 |
| Allopurinol 200 mg or 300 mg QD | 14.8 |
Serum urate values were obtained at the Month 2 visit. The percentage of subjects whose serum urate was <6.0 mg/dL at the Month 2 visit was summarized. (NCT00430248)
Timeframe: Month 2
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 49.1 |
| Febuxostat 80 mg QD | 74.1 |
| Allopurinol 200 mg or 300 mg QD | 43.2 |
Serum urate values were obtained at the Month 4 visit. The percentage of subjects whose serum urate was <6.0 mg/dL at the Month 4 visit was summarized. (NCT00430248)
Timeframe: Month 4
| Intervention | percentage of subjects (Number) |
|---|---|
| Febuxostat 40 mg QD | 47.1 |
| Febuxostat 80 mg QD | 75.2 |
| Allopurinol 200 mg or 300 mg QD | 45.5 |
Serum urate values were obtained at the Month 6 visit. The percentage of subjects whose serum urate was <6.0 mg/dL at the Month 6 visit was summarized. (NCT00430248)
Timeframe: Month 6
| Intervention | percentage of participants (Number) |
|---|---|
| Febuxostat 40 mg QD | 48.9 |
| Febuxostat 80 mg QD | 75.3 |
| Allopurinol 200 mg or 300 mg QD | 46.6 |
(NCT00246519)
Timeframe: baseline to 18 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| Atenolol +HCTZ Arm | -12.06 |
| HCTZ + Atenolol | -13.33 |
"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 3.44 |
| B (Placebo) | -0.83 |
Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | -5.9 |
| B (Placebo) | 0.90 |
"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 0.21 |
| B (Placebo) | -0.95 |
Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)
| Intervention | mg/dl (Mean) |
|---|---|
| A (Allopurinol) | 2.29 |
| B (Placebo) | 0.14 |
Overall liking of apple crisp with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: Day of taste testing
| Intervention | score on likert rating scale (Mean) |
|---|---|
| Full Sugar Recipe | 7.31 |
| Reduced Sugar Recipe | 6.83 |
| Reduced Sugar Plus Spice Recipe | 7.22 |
Overall liking of oatmeal with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing
| Intervention | score on a likert rating scale (Mean) |
|---|---|
| Full Sugar Recipe | 6.84 |
| Reduced Sugar Recipe | 5.70 |
| Reduced Sugar Plus Spice Recipe | 6.15 |
Overall liking of tea with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing
| Intervention | score on a likert rating scale (Mean) |
|---|---|
| Full Sugar Recipe | 6.00 |
| Reduced Sugar Recipe | 5.62 |
| Reduced Sugar Plus Spice Recipe | 5.85 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 54 |
| Second Place Ranking | 63 |
| Third Place Ranking | 33 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 88 |
| Second Place Ranking | 39 |
| Third Place Ranking | 21 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 66 |
| Second Place Ranking | 41 |
| Third Place Ranking | 42 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 48 |
| Second Place Ranking | 60 |
| Third Place Ranking | 40 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 63 |
| Second Place Ranking | 44 |
| Third Place Ranking | 43 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 49 |
| Second Place Ranking | 50 |
| Third Place Ranking | 50 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 33 |
| Second Place Ranking | 43 |
| Third Place Ranking | 74 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 12 |
| Second Place Ranking | 49 |
| Third Place Ranking | 87 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: Day of taste testings
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 34 |
| Second Place Ranking | 58 |
| Third Place Ranking | 57 |
A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | g (Mean) |
|---|---|
| Ramelteon | 3934.86 |
| Placebo (Sugar Pill) | 5120.92 |
A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | HOMA score (Mean) |
|---|---|
| Ramelteon | 2.4 |
| Placebo (Sugar Pill) | 2.36 |
A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8
| Intervention | cm (Mean) |
|---|---|
| Ramelteon | 106.09 |
| Placebo (Sugar Pill) | 108.37 |
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/L (Mean) |
|---|---|
| Pravastatin | 0.8063 |
| Placebo | -0.5136 |
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/dl (Mean) |
|---|---|
| Pravastatin | -25.565 |
| Placebo | -2.913 |
"The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery measures cognitive functioning within 7 domains: speed of processing, attention/vigilance, working memory (non verbal and verbal), verbal learning, visual learning, reasoning and problem solving and social cognition.~The composite score is calculated by the MATRICS computer program, which equally weights each of the 7 domain scores. The range of composite scores is 20-80. Higher scores indicate higher levels or cognitive functioning, while lower scores indicate lower levels of cognitive functioning." (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | 4.0417 |
| Placebo | 4.125 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 15-105. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -5.625 |
| Placebo | -3.76 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -0.83 |
| Placebo | -0.28 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -2.9583 |
| Placebo | -2.44 |
The Positive and Negative Syndrome Scale (PANSS) is a scale used to rate severity of schizophrenia. All items are summed to calculate the total score. The scale range is 30-210. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -9.416 |
| Placebo | -6.48 |
198 reviews available for uric acid and Hypertension
| Article | Year |
|---|---|
Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis.
Topics: Animals; Atherosclerosis; Comorbidity; Diabetes Mellitus, Type 2; Gout; Humans; Hypertension; Hyperu | 2021 |
Uric Acid, Hypertensive Phenotypes, and Organ Damage: Data from the Pamela Study.
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Humans; Hypertension; Phenotype; Uric Acid | 2022 |
Chronic hypertension and superimposed preeclampsia: screening and diagnosis.
Topics: Aldosterone; Angiogenic Proteins; Biomarkers; Chronic Disease; Cytokines; Female; Humans; Hypertensi | 2022 |
Early life exposure to the Chinese Famine of 1959 - 1961 is an independent risk factor of adulthood elevated homocysteine, hyperuricemia, high LDL, and hypertension.
Topics: Adult; Cardiovascular Diseases; Child; Child, Preschool; China; Cross-Sectional Studies; Famine; Fem | 2022 |
Hypertensive Disorders of Pregnancy: Common Clinical Conundrums.
Topics: Antihypertensive Agents; Female; Humans; Hypertension; Hypertension, Pregnancy-Induced; Labetalol; P | 2022 |
Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk.
Topics: Adolescent; Animals; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Hypertension; Hype | 2022 |
Chronic kidney disease: Which role for xanthine oxidoreductase activity and products?
Topics: Atherosclerosis; Diabetes Mellitus, Type 2; Humans; Hypertension; Hyperuricemia; Purines; Reactive O | 2022 |
Association of hyperuricemia with cardiovascular diseases: current evidence.
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Hyperuricemia; Mal | 2023 |
Does This Child With High Blood Pressure Have Secondary Hypertension?: The Rational Clinical Examination Systematic Review.
Topics: Adolescent; Blood Pressure Monitoring, Ambulatory; Child; Essential Hypertension; Humans; Hypertensi | 2023 |
Update in uric acid, hypertension, and cardiovascular diseases.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Prospective Studies; | 2023 |
Hyperuricemia: A key contributor to endothelial dysfunction in cardiovascular diseases.
Topics: Antioxidants; Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Uric Acid | 2023 |
Uric acid and left ventricular hypertrophy: a gender-based meta-analysis of echocardiographic studies.
Topics: Echocardiography; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Hyperuricemia; Male; | 2024 |
Insights into the relationship between serum uric acid and pulmonary hypertension (Review).
Topics: Cardiovascular Diseases; Humans; Hypertension; Hypertension, Pulmonary; Hyperuricemia; Risk Factors; | 2024 |
Angiotensin Receptor Blockers Effect on Serum Uric Acid-A Class Effect?
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2020 |
Association between uric acid and pulse wave velocity in hypertensive patients and in the general population: a systematic review and meta-analysis.
Topics: Adult; Aged; Aged, 80 and over; Ankle Brachial Index; Arterial Pressure; Biomarkers; Carotid-Femoral | 2020 |
Uric Acid and Hypertension: An Update With Recommendations.
Topics: Animals; Clinical Trials as Topic; Humans; Hypertension; Mendelian Randomization Analysis; Uric Acid | 2020 |
Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age.
Topics: Cardiovascular Diseases; Child; Diabetes Mellitus; Fructose; Humans; Hypertension; Insulin Resistanc | 2020 |
Hyperuricemia as a trigger of immune response in hypertension and chronic kidney disease.
Topics: Humans; Hypertension; Hyperuricemia; Immunity; Renal Insufficiency, Chronic; Uric Acid | 2020 |
The Association of Febuxostat Compared With Allopurinol on Blood Pressure and Major Adverse Cardiac Events Among Adult Patients With Hyperuricemia: A Meta-analysis.
Topics: Aged; Allopurinol; Biomarkers; Blood Pressure; Febuxostat; Female; Gout Suppressants; Humans; Hypert | 2020 |
Predictive value of serum uric acid levels for adverse maternal and perinatal outcomes in pregnant women with high blood pressure. A systematic review and meta-analysis.
Topics: Female; Humans; Hypertension; Infant, Newborn; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnant | 2020 |
The Role of the Gut Microbiota in Coronary Heart Disease.
Topics: Animals; Cholesterol; Coronary Disease; Diabetes Complications; Dyslipidemias; Gastrointestinal Micr | 2020 |
Uric acid and cardiovascular disease: A clinical review.
Topics: Cardiovascular Diseases; Gout; Humans; Hypertension; Hyperuricemia; Risk Factors; Uric Acid | 2021 |
Evaluating the Safety and Tolerability of Azilsartan Medoxomil Alone or in Combination With Chlorthalidone in the Management of Hypertension: A Systematic Review.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Ch | 2021 |
Serum uric acid and risk of prehypertension: a dose-response meta-analysis of 17 observational studies of approximately 79 thousand participants.
Topics: Humans; Hypertension; Medical History Taking; Observational Studies as Topic; Prehypertension; Risk | 2022 |
Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis.
Topics: Cardiovascular Diseases; Coronary Artery Disease; Humans; Hypertension; Prognosis; Risk Factors; Str | 2021 |
Hyperuricemia, Type 2 Diabetes Mellitus, and Hypertension: an Emerging Association.
Topics: Diabetes Mellitus, Type 2; Humans; Hypertension; Hyperuricemia; Risk Factors; Uric Acid | 2017 |
The role of urate-lowering treatment on cardiovascular and renal disease: evidence from CARES, FAST, ALL-HEART, and FEATHER studies.
Topics: Cardiovascular Diseases; Gout; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Kidney Diseas | 2017 |
Effects of serum uric acid on blood-pressure lowering treatment.
Topics: Blood Pressure; Cardiovascular Diseases; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Ris | 2017 |
The Effect of Xanthine Oxidase Inhibitors on Blood Pressure and Renal Function.
Topics: Allopurinol; Blood Pressure; Enzyme Inhibitors; Febuxostat; Glomerular Filtration Rate; Gout Suppres | 2017 |
[URATE AS A POTENTIAL RISK FACTOR OF CARDIOVASCULAR AND RENAL DISEASES].
Topics: Biomarkers; Cardiovascular Diseases; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Renal I | 2016 |
Uric Acid: The Unknown Uremic Toxin.
Topics: Allopurinol; Febuxostat; Glomerular Filtration Rate; Gout Suppressants; Humans; Hypertension; Hyperu | 2018 |
Uric Acid as a Cause of the Metabolic Syndrome.
Topics: AMP Deaminase; Animals; Diabetes Mellitus; Dietary Sugars; Fatty Liver; Fructose; Humans; Hypertensi | 2018 |
Topics: Cohort Studies; Humans; Hypertension; Hyperuricemia; Japan; Prehypertension; Uric Acid | 2018 |
The role of xanthine oxidoreductase and uric acid in metabolic syndrome.
Topics: Adipocytes; Adipogenesis; Animals; Cell Differentiation; Endothelium, Vascular; Humans; Hypertension | 2018 |
Arterial Stiffness in Hypertension: an Update.
Topics: Antihypertensive Agents; Humans; Hypertension; Pulse Wave Analysis; Therapies, Investigational; Uric | 2018 |
The benefits of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers combined with calcium channel blockers on metabolic, renal, and cardiovascular outcomes in hypertensive patients: a meta-analysis.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2018 |
Natural history and risk factors for diabetic kidney disease in patients with T2D: lessons from the AMD-annals.
Topics: Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dyslipidemias; Humans; Hypertension; | 2019 |
New advances in renal mechanisms of high fructose-induced salt-sensitive hypertension.
Topics: Blood Pressure; Fructose; Humans; Hypertension; Kidney; Nitric Oxide; Reactive Oxygen Species; Renin | 2018 |
Uric acid and hypertension: a focused review and practical recommendations.
Topics: Animals; Antioxidants; Blood Pressure; Enzyme Inhibitors; Humans; Hypertension; Hyperuricemia; Kidne | 2019 |
Prevention of Cardiovascular Diseases in Children and Adolescents.
Topics: Adolescent; Age of Onset; Arterial Pressure; Biomarkers; Blood Glucose; Cardiovascular Diseases; Chi | 2019 |
Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia-associated hypertension.
Topics: Angiotensin Receptor Antagonists; Creatinine; Folic Acid; Humans; Hyperhomocysteinemia; Hypertension | 2019 |
Uric acid and the origins of hypertension.
Topics: Humans; Hypertension; Hyperuricemia; Risk Factors; Uric Acid | 2013 |
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?
Topics: Animals; Cardiovascular Diseases; Humans; Hypertension; Kidney; Kidney Diseases; Metabolic Syndrome; | 2013 |
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?
Topics: Animals; Cardiovascular Diseases; Humans; Hypertension; Kidney; Kidney Diseases; Metabolic Syndrome; | 2013 |
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?
Topics: Animals; Cardiovascular Diseases; Humans; Hypertension; Kidney; Kidney Diseases; Metabolic Syndrome; | 2013 |
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?
Topics: Animals; Cardiovascular Diseases; Humans; Hypertension; Kidney; Kidney Diseases; Metabolic Syndrome; | 2013 |
Serum urate: a biomarker or treatment target in pediatric hypertension?
Topics: Animals; Biomarkers; Child; Fructose; Humans; Hypertension; Uric Acid; Uricosuric Agents | 2013 |
Uric acid, hypertension, and cardiovascular and renal complications.
Topics: Animals; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Uric Acid; Va | 2013 |
Serum uric acid and chronic kidney disease: the role of hypertension.
Topics: Aged; Aged, 80 and over; Cohort Studies; Female; Glomerular Filtration Rate; Humans; Hypertension; I | 2013 |
Serum uric acid and the risk of hypertension and chronic kidney disease.
Topics: Animals; Biomarkers; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hypertension; Hyperuricemi | 2014 |
Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies.
Topics: Humans; Hypertension; Hyperuricemia; Incidence; Risk; Uric Acid | 2014 |
Xanthine oxidoreductase in atherosclerosis pathogenesis: not only oxidative stress.
Topics: Adipocytes; Animals; Atherosclerosis; Cardiovascular Diseases; Cell Differentiation; Cell Movement; | 2014 |
Serum uric acid and the risk of cardiovascular and renal disease.
Topics: Cardiovascular Diseases; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Metabolic Syndrome; | 2015 |
Uric acid and coronary artery disease: An elusive link deserving further attention.
Topics: Coronary Artery Disease; Humans; Hypertension; Hyperuricemia; Risk Factors; Uric Acid | 2016 |
Why focus on uric acid?
Topics: Animals; Gout; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Metabolic Syndrome; Risk Fact | 2015 |
Hyperuricemia, urate deposition and the association with hypertension.
Topics: Humans; Hypertension; Hyperuricemia; Kidney; Kidney Diseases; Uric Acid | 2015 |
Health implications of high-fructose intake and current research.
Topics: Animals; Diet; Dietary Sucrose; Fructose; Humans; Hypertension; Hypertriglyceridemia; Insulin; Insul | 2015 |
Uric acid in metabolic syndrome: From an innocent bystander to a central player.
Topics: Diabetes Mellitus; Humans; Hypertension; Hyperuricemia; Metabolic Syndrome; Non-alcoholic Fatty Live | 2016 |
[The First Step Aiming at the Prevention of Hypertension and Atherosclerosis. Identification of Individuals at High Risk of Hypertension].
Topics: Albuminuria; Ankle Brachial Index; Atherosclerosis; Biomarkers; Blood Pressure; Cardiovascular Disea | 2015 |
Novelty in hypertension in children and adolescents: focus on hypertension during the first year of life, use and interpretation of ambulatory blood pressure monitoring, role of physical activity in prevention and treatment, simple carbohydrates and uric
Topics: Adolescent; Age Factors; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory; Child; | 2016 |
Effect of uric acid-lowering therapy on blood pressure: systematic review and meta-analysis.
Topics: Adolescent; Aged; Allopurinol; Antihypertensive Agents; Blood Pressure; Creatinine; Enzyme Inhibitor | 2017 |
Hyperuricemia, Hypertension, and Chronic Kidney Disease: an Emerging Association.
Topics: Disease Progression; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Renal Insufficiency, Ch | 2016 |
Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review.
Topics: Blood Pressure; Body Mass Index; China; Creatinine; Diet, Healthy; Dietary Supplements; Exercise; Fe | 2017 |
Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation.
Topics: Animals; Blood Pressure; Dietary Sugars; Fructose; Healthy Lifestyle; Humans; Hypertension; Hyperuri | 2017 |
The Role of Uric Acid in Hypertension of Adolescents, Prehypertension and Salt Sensitivity of Blood Pressure.
Topics: Adolescent; Age Factors; Blood Pressure; Essential Hypertension; Humans; Hypertension; Hyperuricemia | 2017 |
The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension.
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Comorbidity; Cor | 2008 |
Uric acid: bystander or culprit in hypertension and progressive renal disease?
Topics: Animals; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Rats; Uric Ac | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
Uric acid and cardiovascular risk.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2008 |
The role of hyperuricemia in vascular disorders.
Topics: Animals; Biological Evolution; Cardiovascular Diseases; Disease Models, Animal; Humans; Hypertension | 2009 |
Uric acid: a novel mediator and marker of risk in chronic kidney disease?
Topics: Animals; Biomarkers; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Disease Prog | 2009 |
Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis.
Topics: Adult; Blood Pressure; China; Female; Humans; Hypertension; Male; Middle Aged; Obesity; Prospective | 2009 |
Medical implications of hyperuricemia.
Topics: Animals; Cardiovascular Diseases; Gout; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabo | 2009 |
[Calcium antagonists: current and future applications based on new evidence. The mechanisms on lowering serum uric acid level by calcium channel blockers].
Topics: Anaerobiosis; Calcium Channel Blockers; Cardiovascular Diseases; Depression, Chemical; Gout; Humans; | 2010 |
Chronic kidney disease: a marker of cardiovascular disease.
Topics: Albuminuria; Anemia; Biomarkers; Blood Urea Nitrogen; Cardiovascular Diseases; Creatinine; Glomerula | 2009 |
Uric acid and hypertension: cause or effect?
Topics: Allopurinol; Blood Pressure; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Uric Acid | 2010 |
Uric acid transport and disease.
Topics: Animals; Biological Transport; Glucose Transport Proteins, Facilitative; Gout; Humans; Hypertension; | 2010 |
Uric acid and the development of hypertension.
Topics: Animals; Cross-Sectional Studies; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Kidney; R | 2010 |
Dietary fructose and hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Fructose; Humans; Hypertensi | 2011 |
Uric acid in hypertension and renal disease: the chicken or the egg?
Topics: Allopurinol; Animals; Blood Pressure; Clinical Trials as Topic; Diet; Disease Progression; Fructose; | 2010 |
The effect of fructose on renal biology and disease.
Topics: Diabetes Mellitus; Diet; Dietary Carbohydrates; Fatty Liver; Female; Fructose; Humans; Hypertension; | 2010 |
Diet-induced metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Biomarkers; Cardiovascular Diseases; Citric Acid; Die | 2011 |
Uric acid as a cardiometabolic risk factor: to be or not to be.
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; R | 2011 |
[Hyperuricemia and uro-nephrological disorders].
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diagnosis, Differential; Humans; Hypertension; H | 2011 |
Is there anything good in uric acid?
Topics: Age Factors; Brain Diseases; Cardiovascular Diseases; Female; Gout; Humans; Hypertension; Hyperurice | 2011 |
[Role of uric acid in development of essential hypertension: modern conceptions].
Topics: Animals; Endothelium, Vascular; Humans; Hypertension; Oxidative Stress; Uric Acid | 2011 |
[Role of uric acid in preeclampsia-eclampsia].
Topics: Animals; Causality; Cesarean Section; Eclampsia; Endothelium, Vascular; Female; Humans; Hypertension | 2011 |
Uric acid and hypertension.
Topics: Animals; Humans; Hypertension; Hyperuricemia; Uric Acid | 2011 |
[Lozartan potential in hyperuricemia correction].
Topics: Antihypertensive Agents; Humans; Hypertension; Hyperuricemia; Losartan; Metabolic Syndrome; Uric Aci | 2011 |
Uric acid, hyperuricemia and vascular diseases.
Topics: Coronary Disease; Gout; Humans; Hypertension; Hyperuricemia; Inflammasomes; Inflammation; Metabolic | 2012 |
Cardiovascular and renal effects of hyperuricaemia and gout.
Topics: Biomarkers; Cardiovascular Diseases; Diabetes Complications; Disease Progression; Evidence-Based Med | 2012 |
The role of serum uric acid in cardiovascular disease in type 2 diabetic and non-diabetic subjects: a narrative review.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Hypertension; Risk | 2011 |
Uric acid as one of the important factors in multifactorial disorders--facts and controversies.
Topics: Biomarkers; Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Metabolic Syndrome; Uric A | 2012 |
Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate.
Topics: Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Chlorthalidone; Dose-Response Relation | 2012 |
The role of uric acid in the pathogenesis of hypertension in the young.
Topics: Age Factors; Animals; Child; Child Welfare; Disease Models, Animal; Humans; Hypertension; Hyperurice | 2012 |
Uric acid as a danger signal in gout and its comorbidities.
Topics: Biomarkers; Cardiovascular Diseases; Comorbidity; Crystallization; Diabetes Mellitus; Gout; Humans; | 2013 |
The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome.
Topics: Animals; Endothelium, Vascular; Humans; Hypertension; Hyperuricemia; Inflammation; Metabolic Syndrom | 2012 |
Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
Topics: Animals; Antioxidants; Cardiotonic Agents; Cardiovascular Diseases; Female; Humans; Hypertension; Hy | 2003 |
[HYPERURICEMIA AND ITS CLINICAL SIGNIFICANCE].
Topics: Blood Chemical Analysis; Carbon Isotopes; Coronary Disease; Humans; Hypertension; Hyperuricemia; Kid | 1963 |
Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension.
Topics: Animals; Humans; Hypertension; Models, Biological; Nephrons; Uric Acid | 2004 |
Gout: on the brink of novel therapeutic options for an ancient disease.
Topics: Acute Disease; Benzothiadiazines; Diuretics; Female; Gout; Humans; Hypertension; Hyperuricemia; Kidn | 2004 |
Uric acid, evolution and primitive cultures.
Topics: Animals; Blood Pressure; Global Health; Humans; Hypertension; Hyperuricemia; Morbidity; Mutation; Ur | 2005 |
Clinical evidence for the influence of uric acid on hypertension, cardiovascular disease, and kidney disease: a statistical modeling perspective.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Humans; Hypertension; Kidney Diseases; Models, St | 2005 |
Uric acid and hypertension in adolescents.
Topics: Adolescent; Age of Onset; Blood Pressure; Humans; Hypertension; Prevalence; United States; Uric Acid | 2005 |
Molecular physiology of urate transport.
Topics: Humans; Hypertension; Intestinal Mucosa; Kidney Calculi; Kidney Tubules, Proximal; Muscle, Smooth, V | 2005 |
Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
Topics: Disease Progression; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Kidney Failure, Chronic; | 2005 |
Molecular-specific effects of angiotensin II antagonists: clinical relevance to treating hypertension?
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Humans; Hypertension; Platelet Aggregation Inhibit | 2005 |
Hypertension during pregnancy: a disorder begging for pathophysiological support.
Topics: Eclampsia; Female; Humans; Hypertension; Hypertension, Pregnancy-Induced; Pre-Eclampsia; Pregnancy; | 2005 |
Uric acid--a uremic toxin?
Topics: Animals; Arteriosclerosis; Biomarkers; Enzyme Inhibitors; Humans; Hypertension; Hypertrophy; Hyperur | 2006 |
Serum uric acid and risk of coronary heart disease.
Topics: Coronary Disease; Female; Humans; Hypertension; Male; Risk Factors; Uric Acid | 2005 |
Uric acid and hypertension.
Topics: Humans; Hypertension; Hyperuricemia; Insulin Resistance; Uric Acid | 2005 |
Serum uric acid: a risk factor and a target for treatment?
Topics: Adolescent; Adult; Animals; Blood Pressure; Cardiovascular Diseases; Child; Clinical Trials as Topic | 2006 |
Uric acid and hypertension.
Topics: Animals; Child; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Rats; Uric Acid | 2006 |
Hypertensive renal vascular disease and cardiovascular endpoints.
Topics: Albuminuria; Biomarkers; C-Reactive Protein; Disease Progression; Erythropoietin; Glomerular Filtrat | 2006 |
Consequences of intrauterine growth restriction for the kidney.
Topics: Animals; Apoptosis; Female; Fetal Growth Retardation; Humans; Hypertension; Infant, Newborn; Insulin | 2006 |
[Lifestyle modification for patients with hypertension: alcohol restriction].
Topics: Alcohol Drinking; Animals; Blood Pressure; Cardiovascular Diseases; Glucose; Humans; Hypertension; L | 2006 |
Role of uric acid in hypertension, renal disease, and metabolic syndrome.
Topics: Biomarkers; Blood Pressure; Fructose; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metaboli | 2006 |
Salt-sensitive hypertension--update on novel findings.
Topics: Humans; Hypertension; Insulin; Nephritis; Nephrons; Oxidative Stress; Sodium Channels; Sodium, Dieta | 2007 |
Altered uric acid levels and disease states.
Topics: Animals; Cardiovascular Diseases; Gout; Humans; Hypertension; Hyperuricemia; Inflammation; Kidney Di | 2008 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo | 2007 |
Update on gout: pathophysiology and potential treatments.
Topics: Animals; Cardiovascular Diseases; Gout; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Immu | 2007 |
The conundrum of hyperuricemia, metabolic syndrome, and renal disease.
Topics: Animals; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Kidney; Metabolic Syndrome; Renal | 2008 |
The paradoxical relationship between serum uric acid and cardiovascular disease.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Heart Failure; Humans; Hypertension; Hyperuricemia; | 2008 |
[Idiopathic hyperuricemia with overproduction of uric acid].
Topics: Antihypertensive Agents; Gout; Humans; Hypertension; Hyperuricemia; Hypoxanthine; Muscle, Skeletal; | 2008 |
[Other antihyperuricemic agents].
Topics: Antihypertensive Agents; Cardiovascular Diseases; Drug Therapy, Combination; Fenofibrate; Gout; Gout | 2008 |
Pathogenesis and pathophysiology of essential hypertension.
Topics: Blood Volume; Cardiac Output; Cardiomegaly; Humans; Hypertension; Hypertension, Renovascular; Myocar | 1982 |
[Mild hypertension and the role of diuretics].
Topics: Diuretics; Drug Evaluation; Humans; Hypertension; Hypokalemia; Uric Acid | 1984 |
[Platelet function, serum lipoproteins and clinical aspects in peripheral arterial occlusive disease].
Topics: Adult; Aged; Arterial Occlusive Diseases; Carotid Arteries; Coronary Disease; Epoprostenol; Humans; | 1982 |
[Current theories on the role of hyperuricemia as one of the risk factors in ischemic heart disease].
Topics: Carbohydrate Metabolism; Coronary Disease; Female; Gout; Humans; Hypercholesterolemia; Hypertension; | 1980 |
[Uric acid and arterial hypertension].
Topics: Carbohydrate Metabolism; Cardiovascular Diseases; Endocrine System Diseases; Female; Gout; Humans; H | 1981 |
Renal damage in hypertension.
Topics: Enzymes; Glomerular Filtration Rate; Humans; Hypertension; Kidney Diseases; Kidney Glomerulus; Nephr | 1995 |
[Hypertension, Type II diabetes mellitus and macroangiopathy: risk factors and their association].
Topics: Albuminuria; Alcohol Drinking; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Exercise; Female; H | 1994 |
Evaluation of methods used in the prediction of hypertensive disorders of pregnancy.
Topics: Adult; Angiotensin II; Blood Pressure; Calcium; Cohort Studies; Exercise Test; Female; Fibronectins; | 1994 |
[Polymetabolic syndrome].
Topics: Albuminuria; Cholesterol; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypertension; Insulin; | 1995 |
[Hypertension and hyperuricemia].
Topics: Adolescent; Adult; Animals; Benzothiadiazines; Biological Transport; Calcium Channel Blockers; Cell | 1996 |
[Hyperuricemia and insulin resistance].
Topics: Cardiovascular Diseases; Cholesterol, HDL; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans | 1996 |
[Gout and atherosclerosis].
Topics: Alcohol Drinking; Coronary Artery Disease; Gout; Humans; Hyperlipidemias; Hypertension; Obesity; Pla | 1996 |
[Hyperuricemia].
Topics: Female; Humans; Hyperlipidemias; Hypertension; Male; Uric Acid | 1996 |
[Observations on pe-eclampsia-eclampsia and the advances in the evolution of some laboratory tests].
Topics: Adult; Calcium; Capillary Permeability; Chorionic Gonadotropin; Eclampsia; Female; Humans; Hypertens | 1997 |
The kidney: an unwilling accomplice in syndrome X.
Topics: Diabetes Mellitus, Type 2; Glucose; Homeostasis; Humans; Hyperinsulinism; Hypertension; Insulin; Ins | 1997 |
Symptomless hyperuricaemia in patients with essential hypertension and normal renal function.
Topics: Humans; Hypertension; Kidney; Reference Values; Uric Acid | 1998 |
[Familial juvenile gouty nephropathy].
Topics: Adult; Diagnosis, Differential; Family Health; Female; Gout; Humans; Hypertension; Kidney Diseases; | 1998 |
Reappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease.
Topics: Cardiovascular Diseases; Gout; Humans; Hypertension; Kidney Diseases; Risk Factors; Uric Acid | 1999 |
Is serum uric acid a risk factor for coronary heart disease?
Topics: Biomarkers; Coronary Disease; Female; Humans; Hyperlipidemias; Hypertension; Male; Risk Factors; Uri | 1999 |
[The effects of angiotensin II receptor antagonists on glucose, lipid, and uric acid metabolism in essential hypertensives].
Topics: Angiotensin Receptor Antagonists; Blood Glucose; Humans; Hypertension; Lipid Metabolism; Uric Acid | 1999 |
[Pharmacological characteristics and clinical application of losartan, an orally active AT1 angiotensin II receptor antagonist].
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Chronic Disease; Clinical Trials | 1999 |
Uric acid in hypertension and cardiovascular disease.
Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Biomarkers; Blood Pressure; Coronary Dise | 1999 |
[Insulin sensitizer and urate metabolism].
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Glucose; Gout; Humans; Hyperlipidemias; Hypertension; H | 2000 |
[Uric acid and arterial hypertension].
Topics: Humans; Hypertension; Randomized Controlled Trials as Topic; Uremia; Uric Acid | 2000 |
Insulin resistance: a chicken that has come to roost.
Topics: Coronary Disease; Diabetes Mellitus, Type 2; Fibrinolysis; Genotype; Humans; Hyperinsulinism; Hyperl | 1999 |
[Hyperuricaemia].
Topics: Antihypertensive Agents; Humans; Hypertension; Uric Acid | 2000 |
[Hyperuricemia in hypertension].
Topics: Adolescent; Child; Female; Gout; Humans; Hypertension; Male; Uric Acid | 2000 |
Biochemical and metabolic effects of very-low-salt diets.
Topics: Cholesterol; Cholesterol, LDL; Clinical Trials as Topic; Diet, Sodium-Restricted; Dietary Carbohydra | 2000 |
Serum uric acid as a cardiovascular risk factor for heart disease.
Topics: Female; Heart Diseases; Humans; Hypertension; Male; Predictive Value of Tests; Risk Factors; Uric Ac | 2001 |
Serum uric acid is not an independent risk factor for coronary heart disease.
Topics: Coronary Disease; Female; Humans; Hyperlipidemias; Hypertension; Male; Risk Factors; Uric Acid | 2001 |
[Hyperuricemia in hypertension].
Topics: Antihypertensive Agents; Cardiovascular Diseases; Diuretics; Drug Therapy, Combination; Humans; Hype | 2001 |
[Multiple risk factor syndrome and hyperuricemia].
Topics: Female; Humans; Hyperlipidemias; Hypertension; Male; Myocardial Ischemia; Obesity; Risk Factors; Uri | 2001 |
Metabolic profile of indapamide sustained-release in patients with hypertension: data from three randomised double-blind studies.
Topics: Adolescent; Adult; Aged; Blood Glucose; Creatinine; Delayed-Action Preparations; Diuretics; Double-B | 2001 |
Hypertensive disease in twin pregnancies: a review.
Topics: Eclampsia; Female; Humans; Hypertension; Incidence; Pregnancy; Pregnancy Complications, Cardiovascul | 2002 |
[Renal markers and predictors, and renal and cardiovascular risk factors].
Topics: Age Factors; Alcohol Drinking; Biomarkers; Blood Pressure; Cardiovascular Diseases; Fatty Acids; Hum | 2002 |
[Drug therapy in hypertension 1977. Empirical and rational viewpoints].
Topics: Adrenergic Agents; Adrenergic beta-Antagonists; Age Factors; Aged; Blood Volume; Diuretics; Drug The | 1978 |
[Hyperuricemia and arteriosclerosis].
Topics: Adult; Arteriosclerosis; Coronary Disease; Dehydroepiandrosterone; Female; Gout; Humans; Hyperlipide | 1978 |
Risk factors for coronary heart disease.
Topics: Animals; Beverages; Blood Vessels; Cholesterol; Contraceptives, Oral; Coronary Disease; Diabetes Com | 1978 |
[Primary hyperparathyroidism. Clinical aspects, diagnosis and surgical treatment].
Topics: Adenoma; Aged; Bone Cysts; Female; Gout; Humans; Hypercalcemia; Hyperparathyroidism; Hypertension; K | 1977 |
Assessment of renal functions in hypertensive pregnancies.
Topics: Acute Kidney Injury; Female; Fetal Death; Humans; Hypertension; Kidney; Kidney Glomerulus; Kidney Tu | 1977 |
[Etiology of arteriosclerosis].
Topics: Arteriosclerosis; Diabetes Complications; Gout; Humans; Hyperlipidemias; Hypertension; Risk; Smoking | 1978 |
[Role of life style and nutrition in the etiology, prevention and therapy of coronary disease with special reference to lipid metabolism].
Topics: Cholesterol, Dietary; Coronary Disease; Diet, Sodium-Restricted; Dietary Fats; Female; Humans; Hyper | 1979 |
Atherosclerosis and urate metabolism.
Topics: Arteriosclerosis; Coronary Disease; Gout; Humans; Hyperlipidemias; Hyperlipoproteinemia Type IV; Hyp | 1979 |
[Significance of physical activity in the prevention of degenerative heart and vascular diseases?].
Topics: Adult; Age Factors; Arteriosclerosis; Body Weight; Cerebral Hemorrhage; Cerebrovascular Disorders; C | 1976 |
[The kidney and uric acid].
Topics: Acute Kidney Injury; Female; Gout; Humans; Hypertension; Kidney; Kidney Calculi; Kidney Diseases; Ki | 1975 |
Diazoxide.
Topics: Blood Pressure; Cardiac Output; Diazoxide; Diuretics; Drug Synergism; Emergencies; Female; Half-Life | 1976 |
Early manifestations and investigation of cerebral arteriosclerosis.
Topics: Angiography; Basilar Artery; Blood Glucose; Brain; Carotid Artery Diseases; Cerebrovascular Disorder | 1976 |
[Arterial hypertension and hyperuricemia].
Topics: Female; Gout; Humans; Hypertension; Kidney; Male; Uric Acid | 1976 |
[Uric acid and arterial hypertension].
Topics: Adolescent; Child; Humans; Hypertension; Purines; Uric Acid | 1992 |
Diuretics in hypertension: clinical experiences.
Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Diuretics; Humans; Hypertension; Hypokalemia; Risk F | 1992 |
[Physiopathological aspects of secondary hyperuricemia].
Topics: Acute Disease; Coronary Disease; Drug-Related Side Effects and Adverse Reactions; Fructose; Glycogen | 1991 |
The metabolic effects of diuretics and other antihypertensive drugs: a perspective as of 1989.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Carbohydrate Metabolism; Diuretics; Humans; Hy | 1990 |
[The management of hyperuricemic patients associated with hypertension].
Topics: Gout; Humans; Hypertension; Uric Acid | 1991 |
[Effect of angiotensin converting enzyme inhibitors on lipid, purine and glucose metabolism].
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Cholesterol; Diabetes Mellitus; Enalapril; | 1989 |
Metabolic effects of antihypertensive drugs.
Topics: Antihypertensive Agents; Arteriosclerosis; Blood Glucose; Cations; Creatinine; Humans; Hypertension; | 1989 |
[Therapeutic schedules in essential arterial hypertension].
Topics: Blood Glucose; Diuretics; Drug Administration Schedule; Humans; Hypertension; Lipids; Potassium; Sym | 1987 |
The dilemma of mild hypertension.
Topics: Arrhythmias, Cardiac; Blood Glucose; Clinical Trials as Topic; Diuretics; Humans; Hypertension; Hypo | 1986 |
Complications of thiazide diuretic therapy: an update.
Topics: Alkalosis; Benzothiadiazines; Blood Volume; Coronary Disease; Death, Sudden; Diuretics; Drug Hyperse | 1986 |
The elderly patient. A special case for diuretic therapy.
Topics: Aged; Aging; Cerebrovascular Disorders; Diuretics; Heart Failure; Humans; Hyperglycemia; Hyperlipide | 1986 |
The diuretic dilemma and the management of mild hypertension.
Topics: Arrhythmias, Cardiac; Blood Glucose; Cholesterol; Diuretics; Humans; Hypertension; Hypokalemia; Uric | 1986 |
The diuretic dilemma and the management of mild hypertension.
Topics: Arrhythmias, Cardiac; Decision Making; Diuretics; Drug Therapy, Combination; Glucose; Humans; Hypert | 1986 |
[Hyperuricemia and essential arterial hypertension].
Topics: Gout; Humans; Hypertension; Kidney; Renal Circulation; Uric Acid | 1985 |
Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy.
Topics: Animals; Body Weight; Diuretics; Edema; Electrolytes; Half-Life; Humans; Hypertension; Intestinal Ab | 1985 |
Does lithium depletion cause atherosclerotic heart-disease?
Topics: Aggression; Animals; Arteriosclerosis; Coronary Disease; Deficiency Diseases; Diabetes Mellitus; Hum | 1969 |
[Conservative therapy of chronic renal failure].
Topics: Allopurinol; Aluminum; Anemia; Antihypertensive Agents; Blood Transfusion; Bone Diseases; Diet Thera | 1969 |
[Lipids and arteriosclerosis].
Topics: Adult; Age Factors; Aged; Animals; Arteriosclerosis; Cats; Cholesterol; Coronary Disease; Dogs; Gout | 1973 |
Editorial: The kidney and uric acid excretion in man.
Topics: Angiotensin II; Animals; Biological Transport, Active; Blood Proteins; Diabetes Insipidus; Diet, Sod | 1972 |
Diuretics and hypertension.
Topics: Azides; Benzothiadiazines; Blood Vessels; Diuretics; Extracellular Space; Humans; Hyperglycemia; Hyp | 1972 |
Precursors and prevention of coronary artery disease. An overview.
Topics: Aging; Coronary Disease; Diabetes Complications; Diet; Female; Humans; Hypercholesterolemia; Hyperli | 1972 |
Epidemiology of coronary heart disease.
Topics: Adult; Aged; Arteriosclerosis; Cholesterol, Dietary; Coronary Disease; Diabetes Complications; Dieta | 1973 |
[Coffee-drinking from the medical point of view].
Topics: Adult; Blood Pressure; Caffeine; Coffee; Diabetes Mellitus; Feeding Behavior; Female; Gout; Health S | 1973 |
Influence of the kidney upon urate homeostasis in health and disease.
Topics: Acute Kidney Injury; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Hypertension; Hy | 1974 |
Mefruside: a preliminary report of its pharmacological properties and therapeutic efficacy in oedema and hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Diuresis; Diuretics; Dose-Response Relationship, Drug; Drug Ev | 1974 |
Antihypertensive action of benzothiadiazines.
Topics: Benzothiadiazines; Chlorothiazide; Guanethidine; Humans; Hyperglycemia; Hypertension; Hypokalemia; M | 1968 |
[The kidney in gout and gout of the kidney].
Topics: Arteriosclerosis Obliterans; Carbohydrate Metabolism; Cerebrovascular Disorders; Diabetes Complicati | 1968 |
Hypertension and renal disease in pregnancy.
Topics: Adrenal Cortex Hormones; Animals; Biopsy; Body Weight; Diet, Sodium-Restricted; Eclampsia; Edema; Fe | 1971 |
Diuretics. II. Clinical considerations.
Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I | 1971 |
306 trials available for uric acid and Hypertension
| Article | Year |
|---|---|
Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome.
Topics: Acrylates; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihyp | 2021 |
Serum uric acid change in relation to antihypertensive therapy with the dihydropyridine calcium channel blockers.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium | 2021 |
Association of serum uric acid with benefits of intensive blood pressure control.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Humans; Hypertension; R | 2023 |
Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function.
Topics: Benzbromarone; Heart Failure; Humans; Hypertension; Hyperuricemia; Stroke Volume; Uric Acid | 2023 |
Urate-lowering drugs for chronic kidney disease with asymptomatic hyperuricemia and hypertension: a randomized trial.
Topics: Benzbromarone; Febuxostat; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Renal Insufficien | 2023 |
Effects of the DASH diet and losartan on serum urate among adults with hypertension: Results of a randomized trial.
Topics: Adult; Dietary Approaches To Stop Hypertension; Female; Gout; Humans; Hypertension; Hyperuricemia; L | 2023 |
The effects of soursop supplementation on blood pressure, serum uric acid, and kidney function in a prehypertensive population in accordance with the 2017 ACC/AHA guideline.
Topics: Annona; Blood Pressure; Dietary Supplements; Humans; Hypertension; Kidney; Prehypertension; Risk Fac | 2020 |
Randomized Dose-Response Study of the New Dual Endothelin Receptor Antagonist Aprocitentan in Hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind | 2020 |
Positive association of serum uric acid with new-onset diabetes in Chinese women with hypertension in a retrospective analysis of the China Stroke Primary Prevention Trial.
Topics: Adult; China; Diabetes Mellitus; Female; Humans; Hypertension; Male; Primary Prevention; Prospective | 2020 |
Assessment of suitable antihypertensive therapies: Combination with high-dose amlodipine/irbesartan vs triple combination with amlodipine/irbesartan/indapamide (ASAHI-AI study).
Topics: Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihyperten | 2020 |
Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia.
Topics: Febuxostat; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Nitriles; Pyridines; Treatment O | 2021 |
Effect of spironolactone on cardiovascular morbidity and mortality in patients with hypertension and glucose metabolism disorders (ESCAM): a study protocol for a pragmatic randomised controlled trial.
Topics: Aged; Female; Glucose Metabolism Disorders; Humans; Hypertension; Male; Middle Aged; Mineralocortico | 2020 |
A Randomized Pilot Study of DASH Patterned Groceries on Serum Urate in Individuals with Gout.
Topics: Cross-Over Studies; Dietary Approaches To Stop Hypertension; Eating; Female; Follow-Up Studies; Frui | 2021 |
Effects of Dietary Patterns on Serum Urate: Results From a Randomized Trial of the Effects of Diet on Hypertension.
Topics: Adult; Dietary Approaches To Stop Hypertension; Dietary Fiber; Female; Fruit; Humans; Hypertension; | 2021 |
Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial.
Topics: Adolescent; Adult; Allopurinol; Blood Pressure; C-Reactive Protein; Cross-Over Studies; Dilatation, | 2021 |
Effects of losartan and enalapril on serum uric acid and GFR in children with proteinuria.
Topics: Adult; Antihypertensive Agents; Child; Enalapril; Glomerular Filtration Rate; Humans; Hypertension; | 2021 |
DASH diet and change in serum uric acid over time.
Topics: Adult; Dietary Approaches To Stop Hypertension; Female; Humans; Hypertension; Male; Middle Aged; Uri | 2017 |
Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; China; Cross-Sectional Studies; Double-Blind Method; Fem | 2017 |
Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Antihypertensive Agents; Biomarkers; Black or African | 2017 |
Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Diet; Diet, Sodium-Restricted; Female; Humans; Hypertensio | 2017 |
Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study.
Topics: Adult; Aged; Antihypertensive Agents; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulat | 2017 |
Effects of a Dietary Approach to Stop Hypertension (DASH) Diet Intervention on Serum Uric Acid in African Americans With Hypertension.
Topics: Aged; Black or African American; Blood Pressure; Dietary Approaches To Stop Hypertension; Female; Hu | 2018 |
Efficacy and Safety of Febuxostat Extended and Immediate Release in Patients With Gout and Renal Impairment: A Phase III Placebo-Controlled Study.
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Colchicine; Cough; Creatinine; Delay | 2019 |
Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis.
Topics: Antihypertensive Agents; Atenolol; Atherosclerosis; Blood Pressure; Carotid Artery Diseases; Dihydro | 2019 |
Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension.
Topics: Animals; Antioxidants; Biomarkers; Blood-Brain Barrier; Brain; Cell Line; Double-Blind Method; Endot | 2019 |
Which is a better treatment for hypertensive patients with diabetes: a combination of losartan and hydrochlorothiazide or a maximum dose of losartan?
Topics: Aged; Albuminuria; Antihypertensive Agents; Diabetes Mellitus, Type 2; Dose-Response Relationship, D | 2013 |
Angiotensin receptor blocker (ARB)-diuretic versus ARB-calcium channel blocker combination therapy for hypertension uncontrolled by ARB monotherapy.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Diur | 2014 |
A comparative study on the effectiveness of losartan/hydrochlorothiazide and telmisartan/hydrochlorothiazide in patients with hypertension.
Topics: Adult; Aged; Benzimidazoles; Benzoates; Blood Pressure; Dose-Response Relationship, Drug; Drug Combi | 2014 |
Does decreasing serum uric acid level prevent hypertension? - a nested RCT in cohort study: rationale, methods, and baseline characteristics of study cohort.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; China; Diet; Female; Human | 2013 |
[Is there an association of uric acid level with preclinical target organ damage in moderate- and high-risk hypertensive patients?].
Topics: Adult; C-Reactive Protein; Female; Humans; Hypertension; Kidney; Kidney Diseases; Male; Middle Aged; | 2013 |
Parallel-group 8-week study on chlorthalidone effects in hypertensives with low kidney function.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Dose-Response Relationship, Dr | 2014 |
Effects of azelnidipine on uric acid metabolism in patients with essential hypertension.
Topics: Aged; Aged, 80 and over; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Creatin | 2014 |
Allopurinol enhances the blood pressure lowering effect of enalapril in children with hyperuricemic essential hypertension.
Topics: Adolescent; Allopurinol; Antihypertensive Agents; Antimetabolites; Blood Pressure; Child; Drug Syner | 2014 |
Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension.
Topics: Adult; Aged; Creatinine; Diuretics; Drug Combinations; Drug Therapy, Combination; Female; Glomerular | 2014 |
Effect of losartan on serum uric acid in hypertension treated with a diuretic: the COMFORT study.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Diuretics; Drug Combinations; Drug Mo | 2015 |
Efficacy and safety of combination therapy of high-dose losartan and hydrochlorothiazide in patients with hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Creatinine; | 2015 |
Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption.
Topics: Adult; Blood Pressure; Body Weight; Dietary Carbohydrates; Energy Intake; Female; Fructose; Humans; | 2015 |
Effects of combined enalapril and folic acid therapy on the serum uric acid levels in hypertensive patients: a multicenter, randomized, double-blind, parallel-controlled clinical trial.
Topics: Adult; Aged; Antihypertensive Agents; China; Double-Blind Method; Drug Therapy, Combination; Enalapr | 2015 |
Effects of a selective aldosterone blocker and thiazide-type diuretic on blood pressure and organ damage in hypertensive patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Blood Pressure; Blood Pressure Determination; Calcium Channel Blo | 2015 |
Impact of irbesartan, an angiotensin receptor blocker, on uric acid level and oxidative stress in high-risk hypertension patients.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Biphenyl Compounds; Female; Humans; Hypertension; | 2015 |
Efficacy and safety of two single-pill fixed-dose combinations of angiotensin II receptor blockers/calcium channel blockers in hypertensive patients (EXAMINER study).
Topics: Aged; Amlodipine; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relatio | 2016 |
Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzhydryl Compounds; Blood | 2016 |
Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middle Aged; Oxidative S | 2016 |
Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients.
Topics: Amlodipine; Atrial Function, Left; Atrial Remodeling; Biomarkers; Blood Pressure; Calcium Channel Bl | 2016 |
Influence of Salt Intake on Association of Blood Uric Acid with Hypertension and Related Cardiovascular Risk.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; | 2016 |
Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid.
Topics: Adult; Black or African American; Cross-Over Studies; Female; Humans; Hypertension; Hyperuricemia; M | 2016 |
Therapeutic strategy for efficient reduction of serum uric acid levels with allopurinol versus benzbromarone in hyperuricemic patients with essential hypertension - A randomized crossover study (terao study).
Topics: Aged; Aged, 80 and over; Allopurinol; Benzbromarone; Drug Administration Schedule; Drug Monitoring; | 2016 |
Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Age Factors; Aged; Amiloride; Antihypertensive Agents; Ateno | 2016 |
Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia.
Topics: Aged; Benzbromarone; Cross-Over Studies; Drug Therapy, Combination; Febuxostat; Female; Gout Suppres | 2017 |
Effect of losartan combined with amlodipine or with a thiazide on uric acid levels in hypertensive patients.
Topics: Amlodipine; Antihypertensive Agents; Biomarkers; Blood Pressure; Dose-Response Relationship, Drug; D | 2017 |
Opposing effects of sodium intake on uric acid and blood pressure and their causal implication.
Topics: Adult; Blood Pressure; Blood Pressure Determination; Diet, Sodium-Restricted; Female; Humans; Hypert | 2016 |
Effect of Uric Acid-Lowering Agents on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Allopurinol; Brachial Artery; Dose-Response Relationship, Drug; Double-Blind Method; Endothel | 2017 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; | 2008 |
[Serum uric acid prevalence and changes post various antihypertensive agents in patients with essential hypertension].
Topics: Aged; Antihypertensive Agents; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertensi | 2008 |
Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response.
Topics: Adult; Aged; Allopurinol; Antimetabolites; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, | 2010 |
Effect of moxonidine and amlodipine on serum YKL-40, plasma lipids and insulin sensitivity in insulin-resistant hypertensive patients-a randomized, crossover trial.
Topics: Adipokines; Adult; Amlodipine; Antihypertensive Agents; Biomarkers; Blood Pressure; Body Size; Chiti | 2010 |
Effects of a low-dose antihypertensive diuretic in combination with losartan, telmisartan, or candesartan on serum urate levels in hypertensive patients.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; B | 2010 |
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Dose-Response Relationship, Dr | 2010 |
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Dose-Response Relationship, Dr | 2010 |
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Dose-Response Relationship, Dr | 2010 |
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Dose-Response Relationship, Dr | 2010 |
Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study.
Topics: Aged; Antihypertensive Agents; Atenolol; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Hy | 2010 |
Comparative effect of interval and continuous training programs on serum uric acid in management of hypertension: a randomized controlled trial.
Topics: Aged; Antihypertensive Agents; Exercise; Exercise Test; Heart Rate; Humans; Hypertension; Male; Meth | 2011 |
[Antihypertensive therapy optimization and endothelial function in patients with gout and chronic urate tubulointerstitial nephritis].
Topics: Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2010 |
Effect of allopurinol on blood pressure and aortic compliance in hypertensive patients.
Topics: Adult; Aged; Allopurinol; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aorta; | 2011 |
Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial.
Topics: Angiotensin II Type 1 Receptor Blockers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 2011 |
Chronic selective endothelin A receptor antagonism reduces serum uric acid in hypertensive chronic kidney disease.
Topics: Cross-Over Studies; Double-Blind Method; Endothelin A Receptor Antagonists; Hypertension; Hyperurice | 2011 |
Uricaemia as a cardiovascular events risk factor in hypertension: the role of interval training programme in its downregulation.
Topics: Aged; Blood Pressure; Double-Blind Method; Down-Regulation; Exercise Therapy; Female; Hospitals, Tea | 2011 |
To study the efficacy of Losartan on urinary uric acid excretion in Thiazide induced hyperuricemic and hypertensive patients.
Topics: Aged; Humans; Hydrochlorothiazide; Hypertension; Hyperuricemia; Kidney; Losartan; Middle Aged; Sodiu | 2011 |
Association of serum uric acid with blood pressure in Japanese men. Cross-sectional study in work-site group.
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Cross-Sectional Studies; Humans; Hyperte | 2011 |
Blood pressure responses and metabolic effects of hydrochlorothiazide and atenolol.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Blood Pressure; Drug Ther | 2012 |
Effects of losartan/hydrochlorothiazide on serum uric acid levels and blood pressure in hypertensive patients.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Hydrochlo | 2011 |
[Clinical implication of endothelial dysfunction in patients with essential arterial hypertension and urate dysbolism with renal damage].
Topics: Adult; Albuminuria; Carotid Intima-Media Thickness; Endothelin-1; Endothelium, Vascular; Female; Hum | 2011 |
Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension--a prospective, randomized, open-labeled, parallel-group, multicenter trial.
Topics: Aged; Aged, 80 and over; Albuminuria; Antihypertensive Agents; Drug Therapy, Combination; Female; Hu | 2012 |
Efficacy and safety of a single-pill fixed-dose combination of high-dose telmisartan/hydrochlorothiazide in patients with uncontrolled hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; B | 2012 |
Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension.
Topics: Adolescent; Adult; Aged; Female; Humans; Hypertension; Male; Metabolic Syndrome; Middle Aged; Obesit | 2012 |
Efficacy and effect on plasma B-type natriuretic peptide concentration of losartan-hydrochlorothiazide for hypertension uncontrolled by losartan-based therapy: subanalysis of a Multicentre Prospective Observational Study.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Diure | 2012 |
Comparison of the efficacy and safety profiles of two fixed-dose combinations of antihypertensive agents, amlodipine/benazepril versus valsartan/hydrochlorothiazide, in patients with type 2 diabetes mellitus and hypertension: a 16-week, multicenter, rando
Topics: Aged; Albuminuria; Amlodipine; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Angiot | 2012 |
A vasodilating β1 blocker celiprolol inhibits muscular release of uric acid precursor in patients with essential hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Blood Pressure; Celiprolol; Exercise Test; Female; For | 2013 |
Effects of combined antihypertensive therapy with losartan/hydrochlorothiazide on uric acid metabolism.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Dose-Response Relationship, Drug; Drug Th | 2012 |
Blood pressure and metabolic efficacy of fixed-dose combination of perindopril and indapamide in everyday practice.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Indapamide; | 2013 |
AT1 blockers and uric acid metabolism: are there relevant differences?
Topics: Acrylates; Angiotensin Receptor Antagonists; Antihypertensive Agents; Double-Blind Method; Humans; H | 2002 |
Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist therapy in hypertensive renal transplant recipients.
Topics: Adult; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2002 |
Serum uric acid and hemorheology in borderline hypertensives and in subjects with established hypertension and left ventricular hypertrophy.
Topics: Adolescent; Adult; Aged; Blood Glucose; Blood Viscosity; Body Mass Index; Glucose Clamp Technique; H | 2003 |
[Evaluation of lercanidipine in the general practice setting].
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Cholesterol; Diab | 2003 |
Doxazosin GITS versus hydrochlorothiazide as add-on therapy in patients with uncontrolled hypertension.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cholesterol; Do | 2003 |
Effects of a low dose of indapamide, a diuretic, given daily or every-other-day on blood pressure and metabolic parameters.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Diuretics; Dos | 2004 |
Associations between plasma antioxidants and hypertension in a community-based sample of 415 Australians aged 60-64.
Topics: Age Factors; Antioxidants; beta Carotene; Biomarkers; Blood Pressure; Chromatography, High Pressure | 2005 |
Effect of indapamide on urinary calcium excretion in patients with and without urinary stone disease.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium; Calcium Metabolism Disorders; Creatinine; D | 2005 |
Effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricaemia in Chinese population.
Topics: Angiotensin II Type 1 Receptor Blockers; Asian People; Biphenyl Compounds; Blood Pressure; China; Do | 2006 |
Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level.
Topics: Adult; Aged; Allopurinol; Creatinine; Disease Progression; Enzyme Inhibitors; Female; Follow-Up Stud | 2006 |
Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics.
Topics: Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diuretics; Female; Fibr | 2006 |
Improved insulin sensitivity with the angiotensin II-receptor blocker losartan in patients with hypertension and other cardiovascular risk factors.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Bloo | 2006 |
[The effects of angiotensin II receptor blockers in hypertensive patients complicating hyperuricaemia].
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Double-Blind Method; Female; Fol | 2006 |
Lack of association between serum uric acid and organ damage in a never-treated essential hypertensive population at low prevalence of hyperuricemia.
Topics: Adult; Albuminuria; Carotid Artery Diseases; Female; Humans; Hypertension; Hypertrophy, Left Ventric | 2007 |
Antihypertensive efficacy and safety of fixed-dose combination therapy with losartan plus hydrochlorothiazide in Japanese patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Drug Therapy, Combination; Fema | 2007 |
Ambulatory blood pressure-lowering effects of valsartan and enalapril after a missed dose in previously untreated patients with hypertension: a prospective, randomized, open-label, blinded end-point trial.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Chole | 2008 |
Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Glucose; Cholesterol; Drug Therapy, Comb | 2008 |
Synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling, and C-reactive protein in hypertensive patients with primary hypercholesterolemia.
Topics: Aged; Amlodipine; Antihypertensive Agents; Atorvastatin; Blood Pressure; C-Reactive Protein; Drug Sy | 2008 |
Long-term antihypertensive, metabolic and cellular effects of enalapril.
Topics: Adult; Blood Pressure; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Enalapril; E | 1984 |
Labetalol and lipids.
Topics: Cholesterol; Clinical Trials as Topic; Ethanolamines; Humans; Hypertension; Labetalol; Random Alloca | 1981 |
A comparative trial of fixed ratio beta-adrenoceptor blocker and diuretic combination products in moderate hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topi | 1980 |
Low sodium/high potassium diet for prevention of hypertension: probable mechanisms of action.
Topics: Adult; Blood Pressure; Body Weight; Creatine; Diet, Sodium-Restricted; Humans; Hypertension; Male; P | 1981 |
New design for clinical trial of antihypertensive drugs applied to pindolol, clopamide, and combinations thereof.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Clopamide; Drug Therapy, Combination; Female; | 1982 |
Incidence and importance of metabolic side-effects during antihypertensive therapy.
Topics: Adrenergic beta-Antagonists; Bendroflumethiazide; Blood Glucose; Cholesterol; Clinical Trials as Top | 1983 |
Assessment of the antihypertensive effect of a retard preparation of furosemide (Lasix retard) in monotherapy of mild hypertension.
Topics: Aged; Blood Glucose; Blood Pressure; Delayed-Action Preparations; Female; Furosemide; Humans; Hypert | 1981 |
Plasma lipid and lipoprotein changes in hypertensive patients treated with propranolol and prazosin.
Topics: Apoproteins; Blood Glucose; Blood Pressure; Cholesterol; Humans; Hypertension; Lipoproteins; Prazosi | 1982 |
Ventricular extrasystoles during thiazide treatment: substudy of MRC mild hypertension trial.
Topics: Adult; Bendroflumethiazide; Cardiac Complexes, Premature; Female; Humans; Hypertension; Male; Middle | 1983 |
Safety and effects of potassium- and magnesium-containing low sodium salt mixtures.
Topics: Aged; Blood Glucose; Carbon Dioxide; Cholesterol; Creatinine; Diet, Sodium-Restricted; Female; Human | 1984 |
[Treatment of hypertensive hyperuricemic patients with a new beta blocker-diuretic combination].
Topics: Adult; Aged; Atenolol; Celiprolol; Chlorthalidone; Drug Combinations; Drug Tolerance; Female; Humans | 1984 |
Placebo-controlled trial of a combination of bemetizide and triamterene ('Hypertane') in mild or moderate hypertension.
Topics: Adult; Aged; Benzothiadiazines; Clinical Trials as Topic; Creatinine; Double-Blind Method; Drug Comb | 1983 |
Multicentre controlled trial of tienilic acid in hyperuricaemic, hypertensive subjects, with intensive monitoring of liver function.
Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Creatinine; Electrolytes; Female; Glycolates; Hu | 1983 |
Clinical efficacy and safety of indapamide in essential hypertension.
Topics: Adult; Aged; Animals; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electrolytes; Humans | 1983 |
Double-blind comparison between propranolol and bendroflumethiazide in captopril-treated resistant hypertensive patients.
Topics: Bendroflumethiazide; Body Weight; Captopril; Clinical Trials as Topic; Double-Blind Method; Drug Res | 1983 |
Indapamide in hypertension: results of a French multi-centre study in ambulant subjects.
Topics: Aged; Ambulatory Care; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diuretics; Heart Rat | 1983 |
[Evaluation of the antihypertensive efficacy of acebutolol, chlorthalidone and the combination of acebutolol and chlorthalidone in the treatment of mild and moderate primary arterial hypertension].
Topics: Acebutolol; Adult; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; Fema | 1983 |
Increased plasma vasopressin and serum uric acid in the low renin type of essential hypertension.
Topics: Atenolol; Blood Pressure; Body Weight; Catecholamines; Heart Rate; Humans; Hypertension; Male; Middl | 1984 |
Hydrochlorothiazide and bendroflumethiazide in low doses--a comparative trial.
Topics: Adult; Aged; Bendroflumethiazide; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Double-Bl | 1984 |
A double-blind multicentre study of piretanide and hydrochlorothiazide in patients with essential hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Human | 1984 |
Patients compliance in hypertension--the importance of number of tablets.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clopamide; Drug Combinations; Drug Therapy, Combina | 1984 |
Antihypertensive therapy in elderly patients. Ninth interim report. The European Working Party on High Blood Pressure in the Elderly (EWPHE).
Topics: Aged; Antihypertensive Agents; Clinical Trials as Topic; Creatinine; Double-Blind Method; Female; Hu | 1984 |
[A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension].
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Creatinine; Drug Combinations; Fem | 1984 |
Clinical experience with a new combination formulation of triamterene and hydrochlorothiazide (Maxzide) in patients with mild to moderate hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; | 1984 |
[Xipamide in the treatment of mild to moderate systemic arterial hypertension].
Topics: Adult; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diuretics; Female; Humans; Hypertens | 1984 |
The efficacy and acceptability of the combination of acebutolol and hydrochlorothiazide in the treatment of essential hypertension.
Topics: Acebutolol; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Combinations; Female; Humans | 1984 |
Effect on intra-arterial blood pressure of slow release metoprolol combined with placebo or chlorthalidone.
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Delayed-Action Preparations; | 1983 |
Blood pressure in survivors of myocardial infarction. The Coronary Drug Project Research Group.
Topics: Adult; Age Factors; Blood Glucose; Blood Pressure; Body Weight; Electrocardiography; Heart Rate; Hum | 1984 |
[Does short-term fasting lower the cardiovascular risk in obesity? Effects of the composition of the reducing diet].
Topics: Adult; Blood Glucose; Body Weight; Diet, Reducing; Dietary Fats; Female; Humans; Hypertension; Male; | 1983 |
Long term treatment with tienilic acid or thiazides: comparison of antihypertensive and metabolic effects.
Topics: Adult; Amiloride; Blood Pressure; Female; Glycolates; Humans; Hydrochlorothiazide; Hypertension; Liv | 1983 |
Tienilic acid in patients with impaired renal function.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Follow-Up Studies; Glycolates; Humans; Hypertension; | 1982 |
Effect of low dose diuretics on plasma and blood cell electrolytes, plasma uric acid and blood glucose.
Topics: Adult; Amiloride; Blood Glucose; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electroly | 1982 |
[Ambulant treatment of hypertension with cardiotensin (author's transl)].
Topics: Adult; Aged; Benzothiadiazines; Bupranolol; Clinical Trials as Topic; Drug Combinations; Female; Hum | 1981 |
The treatment of mild to moderate essential hypertension with tienilic acid (ticrynafen).
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Glycolates; Heart Rate; Humans; Hydrochloroth | 1980 |
Evaluation of a fixed combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A long-term multicentre trial.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Diastole; Drug Combinations; Femal | 1980 |
Serum lipoprotein levels during chlorthalidone therapy. A Veterans Administration-National Heart, Lung, and Blood Institute cooperative study on antihypertensive therapy: mild hypertension.
Topics: Adult; Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as T | 1980 |
Effect of tienilic acid and amiloride in healthy volunteers and in hypertensives with normal renal function.
Topics: Adolescent; Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Therap | 1980 |
Echocardiographic evaluation of left ventricular function in patients showing an antihypertensive and biochemical response to indapamide.
Topics: Adult; Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Echocardiography; Female; Heart | 1981 |
Antihypertensive therapy in patients above age 60 with systolic hypertension. A progress report of the European Working Party on High Blood Pressure in the Elderly (EWPHE).
Topics: Aged; Blood Glucose; Blood Pressure; Creatinine; Drug Therapy, Combination; Electrolytes; Female; Hu | 1982 |
[Propranolol, triamteren and hydrochlorothiazide in fixed combinations in the treatment of hypertension (author's transl)].
Topics: Adolescent; Adult; Blood Pressure; Double-Blind Method; Drug Combinations; Female; Heart Rate; Human | 1981 |
Chlorthalidone in mild hypertension - dose response relationship.
Topics: Adult; Blood Pressure; Chlorthalidone; Dose-Response Relationship, Drug; Female; Humans; Hypertensio | 1981 |
[Diuretics and vascular risk factors. Comparison between tienilic acid and chlorothiazide (author's transl)].
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Chlorothiazide; Female; Glycolates; Humans; Hypertension | 1981 |
Comparison of the alpha and beta blocking drug, labetalol, and methyl dopa in the treatment of moderate and severe pregnancy-induced hypertension.
Topics: Adult; Blood Pressure; Creatinine; Ethanolamines; Female; Fetus; Humans; Hydralazine; Hypertension; | 1980 |
The effect of rest and ambulation on plasma urea and urate levels in pregnant women with proteinuric hypertension.
Topics: Bed Rest; Female; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Proteinu | 1980 |
A comparison of the effects of low- and conventional-dose thiazide diuretic on insulin action in hypertensive patients with NIDDM.
Topics: Adult; Antihypertensive Agents; Bendroflumethiazide; Blood Glucose; Cross-Over Studies; Diabetes Mel | 1995 |
Effects of losartan on a background of hydrochlorothiazide in patients with hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diast | 1995 |
The influence of allopurinol on renal deterioration in familial nepropathy associated with hyperuricemia (FNAH). The Spanish Group for the Study of FNAH.
Topics: Adolescent; Adult; Aged; Allopurinol; Creatinine; Female; Follow-Up Studies; Humans; Hypertension; K | 1994 |
Effects of different antihypertensive drugs on plasma fibrinogen in hypertensive patients.
Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Atenolol; Blood Glucose; Blood Pressur | 1995 |
Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; H | 1994 |
Cilazapril plus hydrochlorothiazide: improved efficacy without reduced safety in mild to moderate hypertension. A double-blind placebo-controlled multicenter study of factorial design.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Cilazapril; Dose-Response Relationship, Drug; Dou | 1994 |
The measurement of diastolic blood pressure during pregnancy: which Korotkoff phase should be used?
Topics: Blood Pressure; Blood Pressure Determination; Female; Fetal Growth Retardation; Humans; Hypertension | 1994 |
[Evaluation of the efficacy and tolerance of three antihypertensive agents used as single-drug therapy, nifedipine, prazosin and acebutolol in severe, idiopathic hypertension in adolescents].
Topics: Acebutolol; Adolescent; Blood Glucose; Blood Pressure; Cholesterol, LDL; Clinical Protocols; Female; | 1993 |
Metabolic effects of strict salt restriction in essential hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Body Weight; Creatinine; Diet, Sodium-Restricted; Double-Blind Method; | 1993 |
Clinical pharmacology of multiple-dose losartan, an angiotensin II receptor antagonist, in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pr | 1996 |
Effects of losartan on renal function in patients with essential hypertension.
Topics: Albuminuria; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Com | 1996 |
Effect of insulin on renal sodium and uric acid handling in essential hypertension.
Topics: Adult; Blood Pressure; Female; Humans; Hyperinsulinism; Hypertension; Insulin Resistance; Kidney; Ma | 1996 |
A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects.
Topics: Adult; Aged; Aged, 80 and over; Animals; Blood Pressure; Blood Urea Nitrogen; Body Weight; Chlorides | 1996 |
The effects of angiotensin II receptor blockade with losartan on systemic blood pressure and renal and extrarenal prostaglandin synthesis in women with essential hypertension.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphen | 1995 |
[Evaluation of fetal condition in pregnancy complicated by hypertension--biochemical assessment of amniotic fluid. I. Protein and lipid components and kidney maturation].
Topics: Adult; Albumins; Amniotic Fluid; Cholesterol; Creatinine; Female; Humans; Hypertension; Hypertension | 1996 |
Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: The Systolic Hypertension in the Elderly Program. SHEP Cooperative Re
Topics: Aged; Antihypertensive Agents; Blood Glucose; Chlorthalidone; Diuretics; Double-Blind Method; Female | 1998 |
The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension.
Topics: Acrylates; Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Creatinine; Cross-Over | 1998 |
Antihypertensive treatment in postmenopausal women: results from a prospective, randomized, double-blind, controlled study comparing an ACE inhibitor (moexipril) with a diuretic (hydrochlorothiazide).
Topics: Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Choleste | 1998 |
Long-term therapy with an ACE inhibitor, temocapril, reduces microalbuminuria in essential hypertension.
Topics: Albuminuria; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cough; | 1998 |
Long-term effects of diltiazem and atenolol on blood glucose, serum lipids, and serum urate in hypertensive patients. Swedish-Finnish Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Captopril; Diltiazem; Humans; Hyperte | 1999 |
Frequency and determinants of white coat hypertension in mild to moderate hypertension: a primary care-based study. Monitorización Ambulatoria de la Presión Arterial (MAPA)-Area 5 Working Group.
Topics: Adult; Aged; Albuminuria; Blood Glucose; Blood Pressure Determination; Blood Pressure Monitoring, Am | 1999 |
Effect of eprosartan and losartan on uric acid metabolism in patients with essential hypertension.
Topics: Acrylates; Administration, Oral; Aged; Antihypertensive Agents; Double-Blind Method; Female; Humans; | 1999 |
Matrix study of irbesartan with hydrochlorothiazide in mild-to-moderate hypertension.
Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diuretics; Double-Blind Method; Drug Co | 1999 |
Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans?
Topics: Black People; Coronary Disease; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middl | 1999 |
Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia.
Topics: Adult; Aged; Antihypertensive Agents; Benzothiadiazines; Diuretics; Double-Blind Method; Female; Hum | 1999 |
Comparison of antihypertensive and metabolic effects of losartan and losartan in combination with hydrochlorothiazide--a randomized controlled trial.
Topics: Antihypertensive Agents; Blood Platelets; Blood Pressure; Diuretics; Double-Blind Method; Drug Thera | 2000 |
Antihypertensive efficacy of manidipine and enalapril in hypertensive diabetic patients.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood | 2000 |
Long-term effects of losartan and enalapril, alone or with a diuretic, on ambulatory blood pressure and cardiac performance in hypertension: a case-control study.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Blood Pres | 2000 |
Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP).
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Biomarkers; Cardiovascular Dis | 2000 |
Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Glucose; Blood | 2000 |
Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension.
Topics: Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channe | 2001 |
The effect of ACE inhibitor and angiotensin II receptor antagonist therapy on serum uric acid levels and potassium homeostasis in hypertensive renal transplant recipients treated with CsA.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive A | 2001 |
Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics.
Topics: Albuminuria; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, | 2001 |
Diet and medication in the treatment of hyperuricemia in hypertensive patients.
Topics: Allopurinol; Benzothiadiazines; Cardiovascular Diseases; Diet; Diuretics; Energy Intake; Ethanol; Ex | 2001 |
Bisoprolol vs. chlorthalidone: a randomized, double-blind, comparative study in arterial hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Bisoprolol; Blood Pressure; Chi-Square | 1990 |
Uricosuric effect of losartan in patients with renal transplants.
Topics: Adult; Angiotensin Receptor Antagonists; Cross-Over Studies; Cyclosporine; Drug Administration Sched | 2001 |
Losartan versus valsartan in the treatment of patients with mild to moderate essential hypertension: data from a multicenter, randomized, double-blind, 12-week trial.
Topics: Adult; Antihypertensive Agents; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; M | 2001 |
Comparative effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricaemia and gout.
Topics: Aged; Antihypertensive Agents; Biphenyl Compounds; Chronic Disease; Cross-Over Studies; Double-Blind | 2001 |
The effects of the addition of losartan on uric acid metabolism in patients receiving indapamide.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hyp | 2000 |
Double-blind, crossover, comparative study of doxazosin and enalapril in the treatment of hypertension in renal transplant patients under cyclosporine immunosuppression.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood Press | 2002 |
[Estimation of blood pressure, selected biochemical parameters and indices of left ventricular heart function in patients with mild or moderate essential hypertension treated with potassium losartan].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Bilirubin; Blood Glucose; Blood Pressu | 2001 |
The effect of metoprolol --a new selective adrenergic beta1-receptor blocking agent-- in mild hypertension.
Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Pressure; Body Weight; Clinical Trials as Topic; Depr | 1976 |
Comparison between metoprolol and propranolol as antihypertensive agents. A double-blind cross-over study.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Body Weight; Clinical Trials as Topic; Depression, Chem | 1976 |
Treatment of arterial hypertension with tienilic acid, a new diuretic with uricosuric properties.
Topics: Adult; Blood Pressure; Blood Urea Nitrogen; Calcium; Clinical Trials as Topic; Diuretics; Double-Bli | 1978 |
Combination therapy with saluretics and atenolol in essential hypertension. Effects on blood pressure, electrolytes and uric acid.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Bendroflumethiazide; Chlorthalidone; Diuretics; | 1979 |
Tienilic acid in mild to moderate hypertension.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combinatio | 1979 |
Plasma-urate measurements in predicting fetal death in hypertensive pregnancy.
Topics: Blood Pressure; Chronic Disease; Female; Fetal Death; Gestational Age; Glomerular Filtration Rate; H | 1976 |
Comparison of tienilic acid with cyclopenthiazide in hyperuricaemic hypertensive patients.
Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Cyclopenthiazide; Diuretics; Drug Evaluation; | 1978 |
Beta-blockers and uric-acid excretion.
Topics: Amiloride; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyr | 1978 |
Biochemical and haematological changes induced by tienilic acid combined with propranolol in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Blood Sedimentation; Clinical Trials as Topic; Creatinine; Diuretics; D | 1979 |
Clinical study of ticrynafen. A new diuretic, antihypertensive, and uricosuric agent.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Diureti | 1977 |
Diuretic therapies in low renin and normal renin essential hypertension.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Combinations | 1977 |
Antihypertensive therapy in elderly patients. Pilot trial of the European Working Party on High Blood Pressure in the Elderly.
Topics: Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Female; Humans; Hydrochloro | 1977 |
Ticrynafen: a novel uricosuric antihypertensive natriuretic agent.
Topics: Blood Pressure; Blood Urea Nitrogen; Blood Volume; Body Weight; Clinical Trials as Topic; Creatinine | 1978 |
Ticrynafen and hydrochlorothiazide in hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Ethacrynic Acid; Humans; Hydro | 1978 |
Dose response to chlorthalidone in patients with mild hypertension. Efficacy of a lower dose.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Dose-Response | 1978 |
Antihypertensive therapy in patients above age 60. Third interim report of the European Working Party on High blood pressure in Elderly (EWPHE).
Topics: Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Double-Blind Method; Europe | 1978 |
A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension.
Topics: Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Chlorides; Clinical T | 1978 |
Hydrochlorothiazide and spironolactone in hypertension.
Topics: Adult; Aldosterone; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; Cr | 1979 |
Antihypertensive therapy in patients above age 60 years (Fourth Interim report of the European Working Party on High Blood pressure in Elderly: EWPHE).
Topics: Aged; Aging; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Doubl | 1978 |
Comparison of natriuretic, uricosuric, and antihypertensive properties of tienilic acid, bendrofluazide, and spironolactone.
Topics: Bendroflumethiazide; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Glyco | 1979 |
Ticrynafen and hydrochlorothiazide. A double-blind study of antihypertensive properties with an open crossover.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Glyco | 1979 |
[Experiences with a new hypouricemic diuretic (tienilic acid): comparison with hydrochlorothiazide].
Topics: Adult; Clinical Trials as Topic; Diuretics; Female; Glycolates; Heart Arrest; Humans; Hydrochlorothi | 1978 |
Comparative effects of ticrynafen and hydrochlorothiazide in the treatment of hypertension.
Topics: Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Glycolates; Humans; Hydroc | 1979 |
Ticrynafen and probenecid in hyperuricemic, hypertensive men.
Topics: Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; Creatinine; Diuresis; Double-Blind Me | 1979 |
Serum potassium and uric acid changes during treatment with timolol alone and in combination with a diuretic.
Topics: Amiloride; Clinical Trials as Topic; Creatinine; Diuretics; Drug Combinations; Drug Therapy, Combina | 1979 |
A double-blind study of tienilic acid with two year follow-up of patients with mild to moderate essential hypertension.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Follow-Up Studies; Glycolates; Humans; Hydroch | 1979 |
Propranolol and tienilic acid in essential hypertension.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Glyco | 1979 |
Long-term usage of tienilic acid in essential hypertension.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Glycolates; Humans; Hydrochlorothiazide; Hyper | 1979 |
Safety of tienilic acid.
Topics: Clinical Trials as Topic; Glycolates; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Kidn | 1979 |
Studies on tienilic acid in hypertensive hyperuricaemic patients in Dunedin, New Zealand.
Topics: Aged; Allopurinol; Clinical Trials as Topic; Cyclopenthiazide; Diuretics; Drug Therapy, Combination; | 1979 |
Double-blind assessment of tienilic acid in essential hypertension.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Glycolates | 1979 |
The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Double-Blind Method; Drug A | 1979 |
Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients.
Topics: Adolescent; Adult; Aged; Blood Cell Count; Blood Glucose; Clinical Trials as Topic; Electrolytes; Fe | 1979 |
An evaluation of tienilic acid, a new diuretic uricosuric agent, in the therapy of arterial hypertension.
Topics: Adolescent; Adult; Aged; Blood Glucose; Blood Pressure; Cholesterol; Clinical Trials as Topic; Creat | 1979 |
One year follow-up of hyperuricaemic hypertensive patients treated with tienilic acid or a diuretic with or without uric acid-lowering drugs.
Topics: Alkaline Phosphatase; Amiloride; Aspartate Aminotransferases; Bilirubin; Blood Pressure; Clinical Tr | 1979 |
Randomised comparison of methyldopa and oxprenolol for treatment of hypertension in pregnancy.
Topics: Adult; Birth Weight; Blood Glucose; Creatinine; Female; Humans; Hypertension; Methyldopa; Oxprenolol | 1979 |
Uricosuric effect of tienilic acid in normo- and hyperuricaemic hypertensive patients.
Topics: Adult; Aged; Creatinine; Glycolates; Humans; Hypertension; Male; Middle Aged; Sodium; Ticrynafen; Ur | 1979 |
[Tienilic acid in the treatment of arterial hypertension and congestive cardiac insufficiency].
Topics: Adult; Aged; Diuresis; Drug Evaluation; Female; Glycolates; Heart Failure; Humans; Hydrochlorothiazi | 1979 |
Antihypertensive effect of various doses of hydrochlorothiazide and its relation to the plasma level of the drug.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Female; Glucose Tolerance Test; Humans; H | 1978 |
Treatment of benign essential hypertension: comparison of furosemide and hydrochlorothiazide.
Topics: Adult; Bicarbonates; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuresis; Dose-Response | 1975 |
Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart | 1976 |
Dietary sodium chloride in pregnant hypertensive patients: a preliminary report.
Topics: Clinical Trials as Topic; Diet; Female; Humans; Hypertension; Placebos; Pre-Eclampsia; Pregnancy; Pr | 1976 |
A double-blind study of chlorthalidone and hydrochlorothiazide in an outpatient population of moderate hypertensives.
Topics: Adult; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Female; Humans | 1976 |
Antihypertensive effect and side-effects of bendroflumethiazide and propranolol.
Topics: Bendroflumethiazide; Blood Glucose; Blood Pressure; Heart Rate; Humans; Hypertension; Insulin; Male; | 1976 |
Effect of different doses of chlorthalidone on blood pressure, serum potassium, and serum urate.
Topics: Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Depression, Chemical; Female; Humans; Hype | 1975 |
A double-blind study in hypertensive patients of an original new compound, indapamide.
Topics: Adult; Antihypertensive Agents; Benzamides; Blood Pressure Determination; Blood Proteins; Blood Urea | 1975 |
Return of elevated blood pressure after withdrawal of antihypertensive drugs.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Creatine; Glucose To | 1975 |
The effect of spironolactone (Aldactone) and methyldopa in low and normal renin hypertension.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Depression, Chemical; Drug Thera | 1975 |
Effectiveness of advice to reduce alcohol consumption in hypertensive patients.
Topics: Adult; Alcohol Drinking; Analysis of Variance; Aspartate Aminotransferases; Blood Pressure; Counseli | 1992 |
[Beta-thromboglobulin levels and atherosclerosis. Its relationship with the presence of risk factors].
Topics: Aged; Alcoholism; Apolipoproteins B; Arteriosclerosis; beta-Thromboglobulin; Diabetes Complications; | 1992 |
Neurohumoral and metabolic effects of short-term dietary NaCl restriction in men. Relationship to salt-sensitivity status.
Topics: Adult; Blood Glucose; Cholesterol, LDL; Creatinine; Diet, Sodium-Restricted; Hormones; Humans; Hyper | 1991 |
Efficacy and safety of ramipril in combination with hydrochlorothiazide: results of a long-term study.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; B | 1991 |
No major metabolic alterations accompany the hypotensive effect of active vitamin D.
Topics: Aged; Antihypertensive Agents; Double-Blind Method; Female; Glucose; Humans; Hydroxycholecalciferols | 1991 |
[Mononuclear magnesium in elderly hypertensive patients treated with thiazide].
Topics: Aged; Blood Pressure; Female; Humans; Hydrochlorothiazide; Hypertension; Leukocytes, Mononuclear; Ma | 1991 |
A double-blind, randomized, placebo-controlled comparison of the metabolic effects of low-dose hydrochlorothiazide and indapamide.
Topics: Blood Pressure; Body Weight; Double-Blind Method; Female; Heart Rate; Humans; Hydrochlorothiazide; H | 1991 |
Short-term changes in renal function, blood pressure, and electrolyte levels in patients receiving cyclosporine for dermatologic disorders.
Topics: Adult; Aged; Creatinine; Cyclosporins; Double-Blind Method; Drug Administration Schedule; Electrolyt | 1991 |
Systolic Hypertension in the Elderly Program (SHEP). Part 7: Baseline laboratory characteristics.
Topics: Aged; Aged, 80 and over; Black People; Blood Chemical Analysis; Blood Glucose; Enzymes; Female; Huma | 1991 |
The determinants and prognostic significance of serum uric acid in elderly patients of the European Working Party on High Blood Pressure in the Elderly trial.
Topics: Aged; Arthritis, Gouty; Blood Glucose; Cardiovascular Diseases; Cholesterol; Creatinine; Drug Therap | 1991 |
Low-dose cyclopenthiazide in the treatment of hypertension: a one-year community-based study.
Topics: Adult; Aged; Apolipoproteins; Blood Glucose; Cholesterol; Cyclopenthiazide; Drug Administration Sche | 1991 |
Hydrochlorothiazide versus spironolactone: long-term metabolic modifications in patients with essential hypertension.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Diuretics; Double-Blind Method; Female; Humans; Hydrochlor | 1991 |
The treatment of mild hypertension study. A randomized, placebo-controlled trial of a nutritional-hygienic regimen along with various drug monotherapies. The Treatment of Mild Hypertension Research Group.
Topics: Aged; Alcohol Drinking; Antihypertensive Agents; Cholesterol, HDL; Cholesterol, LDL; Diet, Reducing; | 1991 |
Prazosin improves atherogenic index and inhibits the deleterious effect of dihydrochlorothiazide in patients with essential hypertension.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertens | 1987 |
Blood pressure and metabolic responses to hydrochlorothiazide, captopril, and the combination in black and white mild-to-moderate hypertensive patients.
Topics: Black People; Blood Glucose; Blood Pressure; Captopril; Cholesterol; Drug Therapy, Combination; Fema | 1985 |
Comparison of two combined diuretics in the treatment of essential hypertension.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Diuretics; Double-Blind Method; | 1989 |
Effects of traxanox sodium on blood pressure and serum uric acid in hypertensive patients: a preliminary study.
Topics: Adult; Blood Pressure; Chromones; Diuretics; Electrolytes; Female; Humans; Hypertension; Male; Middl | 1989 |
Antihypertensive and hypouricaemic effects of nitrendipine in chronic renal failure.
Topics: Adult; Aged; Angiotensin II; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Age | 1989 |
[Treatment of hypertension with a new beta blocker-diuretic combination under long-term control].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Celiprolol; Chlorthalidone; Clinical Trial | 1985 |
Captopril once daily as monotherapy in patients with hyperuricaemia and essential hypertension.
Topics: Captopril; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertension; Proline; Uric Acid | 1985 |
Mortality findings for stepped-care and referred-care participants in the hypertension detection and follow-up program, stratified by other risk factors. The Hypertension Detection and Follow-up Program Cooperative Research Group.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Body Composition; Cholesterol; Clinical Trials | 1985 |
Enalapril, atenolol, and hydrochlorothiazide in mild to moderate hypertension. A comparative multicentre study in general practice in Norway.
Topics: Adult; Aged; Atenolol; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1986 |
Renal effects of pinacidil in hypertensive patients on chronic beta-blocker therapy.
Topics: Adrenergic beta-Antagonists; Adult; Albuminuria; beta 2-Microglobulin; Blood Pressure; Clinical Tria | 1986 |
Metoprolol or hydrochlorothiazide in patients with hypertension aged 60-75 years. With special reference to assessment of compliance. Hunter Hypertension Research Group.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hydrochlorothia | 1986 |
[Influence of acute administration of ramipril on the excretion of uric acid].
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Bridged Bicyclo Compounds; Bridged-Ring Co | 1987 |
Treating black hypertensives with capozide.
Topics: Black People; Blood Pressure; Blood Urea Nitrogen; Captopril; Clinical Trials as Topic; Creatinine; | 1988 |
Comparison of the metabolic effects of long-term treatment with pindolol or atenolol by hypertensive patients.
Topics: Adult; Atenolol; Blood Glucose; Body Weight; Cholesterol, LDL; Cholesterol, VLDL; Drug Administratio | 1988 |
Dose response to hydrochlorothiazide in hypertensives receiving a calcium channel blocker.
Topics: Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; | 1988 |
Changes in plasma lipids and uric acid with sodium loading and sodium depletion in patients with essential hypertension.
Topics: Blood Pressure; Blood Proteins; Cholesterol; Creatinine; Diet, Sodium-Restricted; Female; Humans; Hy | 1988 |
Comparative study on the antihypertensive efficacy of torasemide and indapamide in patients with essential hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Creatinine; Diuretics; Double- | 1988 |
Efficacy and tolerability of atenolol, nifedipine and their combination in the management of hypertension.
Topics: Adult; Aged; Atenolol; Blood Pressure; Clinical Trials as Topic; Creatinine; Double-Blind Method; Dr | 1988 |
The effects of bendroflumethiazide added to nifedipine in patients with hypertension.
Topics: Adult; Bendroflumethiazide; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; De | 1987 |
Is nifedipine a suitable first-line treatment for essential hypertension in general practice?
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; | 1987 |
Hypertension in elderly patients. A comparative study between indapamide and hydrochlorothiazide.
Topics: Aged; Blood Pressure; Diuretics; Drug Evaluation; Drug Tolerance; Humans; Hydrochlorothiazide; Hyper | 1988 |
Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fema | 1986 |
Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone.
Topics: Age Factors; Aged; Blood Glucose; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic | 1986 |
Clinical features of patients with solitary kidneys.
Topics: Adult; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Hypertension; Kidney; Kidney Fai | 1986 |
The dilemma of mild hypertension.
Topics: Arrhythmias, Cardiac; Blood Glucose; Clinical Trials as Topic; Diuretics; Humans; Hypertension; Hypo | 1986 |
Antihypertensive and biochemical effects of different doses of hydrochlorothiazide alone or in combination with triamterene.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy | 1986 |
Torasemide, a new potent diuretic. Double-blind comparison with furosemide.
Topics: Aged; Aged, 80 and over; Body Weight; Clinical Trials as Topic; Creatinine; Diuretics; Double-Blind | 1986 |
Acute natriuretic effect of nifedipine in hypertensive patients and normotensive controls--a proximal tubular effect?
Topics: Adult; Albuminuria; beta 2-Microglobulin; Blood Pressure; Body Water; Humans; Hypertension; Kidney T | 1987 |
Hydrochlorothiazide and triamterene with sustained-release oxprenolol in the treatment of hypertension.
Topics: Aged; Creatinine; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Kidn | 1986 |
Use of diuretics in treatment of hypertension in the elderly.
Topics: Aged; Chlorthalidone; Creatinine; Double-Blind Method; Female; Humans; Hypertension; Hypokalemia; Ma | 1986 |
A single institution, randomized, prospective trial of cyclosporin versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients.
Topics: Adolescent; Adult; Antilymphocyte Serum; Aspartate Aminotransferases; Azathioprine; Clinical Trials | 1985 |
Beneficial effects from systematic dosage reduction of the diuretic, chlorthalidone: a randomized study within a clinical trial.
Topics: Blood Glucose; Blood Pressure; Chlorthalidone; Cholesterol; Clinical Trials as Topic; Humans; Hypert | 1985 |
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension.
Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D | 1985 |
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension.
Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D | 1985 |
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension.
Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D | 1985 |
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension.
Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D | 1985 |
Hypertension management in the Multiple Risk Factor Intervention Trial (MRFIT). Six-year intervention results for men in special intervention and usual care groups.
Topics: Adult; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clinical Tr | 1985 |
Captopril once daily in patients with essential hypertension and hyperuricaemia.
Topics: Adult; Aged; Blood Pressure; Captopril; Clinical Trials as Topic; Diet, Sodium-Restricted; Female; H | 1985 |
Comparison of cyclothiazide and hydrochlorthiazide in hypertension. Effects of different doses of diuretics.
Topics: Adult; Antihypertensive Agents; Benzothiadiazines; Blood Glucose; Blood Pressure; Clinical Trials as | 1985 |
[Treatment of arterial hypertension with a combination metoprolol-hydrochlorothiazide].
Topics: Blood Pressure; Clinical Trials as Topic; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hy | 1985 |
[Esmaloride--a new potassium neutral diuretic combination. Clinical pharmacologic properties].
Topics: Aldosterone; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Drug Combinations; F | 1985 |
Antihypertensive effects of metolazone (zaroxolyn).
Topics: Adult; Aged; Antihypertensive Agents; Bicarbonates; Blood Glucose; Blood Pressure; Blood Urea Nitrog | 1974 |
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.
Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu | 1972 |
One-tablet combination drug therapy in the treatment of hypertension.
Topics: Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; Dosage Forms; Drug Com | 1972 |
Comparison between alprenolol and chlorthalidone as antihypertensive agents.
Topics: Adult; Alprenolol; Amino Alcohols; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as T | 1972 |
Comparison between alprenolol and propranolol as antihypertensive agents. A double-blind cross-over study.
Topics: Adult; Alprenolol; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart Rate; Humans | 1972 |
Moderate sodium restriction and diuretics in the treatment of hypertension.
Topics: Adult; Body Weight; Clinical Trials as Topic; Diet, Sodium-Restricted; Female; Humans; Hydrochloroth | 1973 |
Effect of alprenolol and alprenolol in combination with saluretics in hypertension.
Topics: Adult; Aged; Alprenolol; Benzothiadiazines; Blood Pressure; Body Weight; Clinical Trials as Topic; D | 1974 |
Long-term effect of alprenolol as antihypertensive agent.
Topics: Adult; Airway Obstruction; Alprenolol; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials | 1974 |
A within-patient comparison of alprenolol and propranolol in hypertension.
Topics: Adult; Alprenolol; Blood Pressure; Depression, Chemical; Female; Heart Rate; Humans; Hypertension; M | 1973 |
Effect of long-term allopurinol administration on serial GFR in normotensive and hypertensive hyperuricemic subjects.
Topics: Adult; Allopurinol; Blood Pressure; Creatinine; Female; Follow-Up Studies; Glomerular Filtration Rat | 1974 |
The combination of guanethidine and hydrochlorothiazide in the treatment of arterial hypertension with and without renal failure.
Topics: Adult; Analysis of Variance; Blood Pressure; Clinical Trials as Topic; Creatine; Drug Synergism; Fem | 1968 |
Treatment of hypertension with quinethazone alone or in combination with reserpine.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Po | 1969 |
Prevention of hyperuricemia by allopurinol in hypertensive patients treated with chlorothiazide.
Topics: Allopurinol; Blood Pressure; Blood Urea Nitrogen; Chlorothiazide; Clinical Trials as Topic; Creatini | 1970 |
[Saluretic treatment of hypertension and uric acid level in serum. Clinical test of a combination of hydrochlorothiazide and probenecid].
Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Blood Protein Electrophoresis; Bod | 1969 |
Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg.
Topics: Adult; Age Factors; Antihypertensive Agents; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Bod | 1970 |
Ethacrynic acid alone and in combination with methyldopa in the management of mild hypertension. A report of 23 patients.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diarrhea; Drug Synergism; Ethacrynic Acid; Fe | 1970 |
Furosemide in essential hypertension. A statistical analysis of three double-blind studies.
Topics: Adult; Aged; Aspartate Aminotransferases; Blood Cell Count; Blood Glucose; Blood Pressure; Blood Ure | 1971 |
A comparison of the effects of hydrochlorothiazide and of frusemide in the treatment of hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Blood Proteins; Carbon Dioxide; Clinical Trials as Topic; Female; Furos | 1971 |
Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels.
Topics: Alanine Transaminase; Amiloride; Aspartate Aminotransferases; Diuretics; Drug Combinations; Humans; | 1972 |
Effect of triamterene on elevated arterial pressure.
Topics: Adult; Blood Chemical Analysis; Chlorthalidone; Clinical Trials as Topic; Creatine; Female; Humans; | 1965 |
Effects of treatment in hypertension. Results of a controlled study.
Topics: Adult; Aged; Black or African American; Blood; Carbohydrate Metabolism; Clinical Trials as Topic; Fe | 1966 |
Potassium-sparing effects of triamterene in the treatment of hypertension.
Topics: Adult; Aged; Blood Gas Analysis; Blood Glucose; Chlorides; Chlorothiazide; Clinical Trials as Topic; | 1966 |
Amiloride hydrochloride in hypertensive patients.
Topics: Bicarbonates; Blood Pressure; Chlorides; Depression, Chemical; Diuretics; Drug Synergism; Guanidines | 1968 |
Metabolic and hypotensive effects of ethacrynic acid. Comparative study with hydrochlorothiazide.
Topics: Analysis of Variance; Aspartate Aminotransferases; Blood Glucose; Blood Pressure; Blood Urea Nitroge | 1968 |
Metabolic and hypotensive effects of a new rauwolfia-thiazide combination.
Topics: Adult; Aged; Bendroflumethiazide; Benzothiadiazines; Blood Glucose; Blood Pressure; Blood Urea Nitro | 1969 |
Long-term effect of probenecid on diuretic-induced hyperuricemia.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure Determination; Body Weight; Chlorthalidone; Hum | 1966 |
1410 other studies available for uric acid and Hypertension
| Article | Year |
|---|---|
Arterial Hypertension and Serum Uric Acid in Elderly- SEPHAR III Study.
Topics: Adult; Aged; Blood Pressure; Carotid Intima-Media Thickness; Humans; Hypertension; Hyperuricemia; Ri | 2021 |
Positive association between body fat percentage and hyperuricemia in patients with hypertension: The China H-type hypertension registry study.
Topics: Adiposity; Biomarkers; Blood Pressure; China; Cross-Sectional Studies; Female; Humans; Hypertension; | 2021 |
Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey.
Topics: Adult; China; Cross-Sectional Studies; Female; Health Surveys; Humans; Hypertension; Hyperuricemia; | 2021 |
Association of uric acid and uric acid to creatinine ratio with chronic kidney disease in hypertensive patients.
Topics: Aged; Biomarkers; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; H | 2021 |
Uric acid levels in primary antiphospholipid syndrome.
Topics: Adult; Age Factors; Antibodies, Anticardiolipin; Antibodies, Antiphospholipid; Antiphospholipid Synd | 2021 |
Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study.
Topics: Humans; Hypertension; Prognosis; Risk Factors; Stroke; Uric Acid | 2022 |
The geriatric nutritional risk index mediated the relationship between serum uric acid and hypertension: a mediation analysis.
Topics: Aged; Blood Pressure; Female; Humans; Hypertension; Male; Mediation Analysis; Nutritional Status; Ri | 2021 |
Triglyceride-glucose index is a predictive index of hyperuricemia events in elderly patients with hypertension: a cross-sectional study.
Topics: Aged; Blood Glucose; Cross-Sectional Studies; Female; Glucose; Humans; Hypertension; Hyperuricemia; | 2022 |
Association between hyperuricemia and hypertension: a case-control study.
Topics: Case-Control Studies; Diabetes Mellitus; Humans; Hypertension; Hyperuricemia; Risk Factors; Uric Aci | 2021 |
Clinical effectiveness and safety of amlodipine/losartan-based single-pill combination therapy in patients with hypertension: Findings from real-world, multicenter observational databases.
Topics: Amlodipine; Antihypertensive Agents; Humans; Hypertension; Losartan; Treatment Outcome; Uric Acid | 2021 |
Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh.
Topics: Adolescent; Adult; Alanine Transaminase; Antihypertensive Agents; Bangladesh; Cholesterol; Cohort St | 2021 |
Association between uric acid level and incidence of albuminuria in patients with type 2 diabetes mellitus: A 4.5-year cohort study.
Topics: Aged; Albuminuria; Animals; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Femal | 2021 |
The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults.
Topics: Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Nutrition Surveys; Risk Factors; Uric | 2021 |
Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study.
Topics: Glomerular Filtration Rate; Humans; Hypertension; Hyperuricemia; Japan; Renal Insufficiency, Chronic | 2021 |
Serum uric acid level is associated with an increase in systolic blood pressure over time in female subjects: Linear mixed-effects model analyses.
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Risk Factors; | 2022 |
Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.
Topics: Adult; Aged; Biomarkers; Blood Glucose; China; Cross-Sectional Studies; Female; Glucose; Humans; Hyp | 2022 |
Serum uric acid is independently associated with metabolic syndrome and systemic hypertension in women from northeast Brazil.
Topics: Brazil; Cross-Sectional Studies; Female; Humans; Hypertension; Metabolic Syndrome; Risk Factors; Uri | 2022 |
High prevalence and low awareness of hyperuricemia in hypertensive patients among adults aged 50-79 years in Southwest China.
Topics: Aged; China; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Prevalence; Risk Factor | 2022 |
Body mass index was linked with multi-cardiometabolic abnormalities in Chinese children and adolescents: a community-based survey.
Topics: Adolescent; Adult; Body Mass Index; Cardiovascular Diseases; Child; Child, Preschool; Humans; Hypert | 2022 |
Impact of serum uric acid levels on the clinical prognosis and severity of coronary artery disease in patients with acute coronary syndrome and hypertension after percutaneous coronary intervention: a prospective cohort study.
Topics: Acute Coronary Syndrome; Coronary Artery Disease; Humans; Hypertension; Percutaneous Coronary Interv | 2022 |
Genetic risk of hyperuricemia in hypertensive patients associated with antihypertensive drug therapy: A longitudinal study.
Topics: Antihypertensive Agents; Diuretics; Glucose Transport Proteins, Facilitative; Humans; Hypertension; | 2022 |
Temporal trends in the prevalence and characteristics of hypouricaemia: a descriptive study of medical check-up and administrative claims data.
Topics: Child; Female; Humans; Hypertension; Male; Parkinson Disease; Prevalence; Purine-Pyrimidine Metaboli | 2022 |
Serum uric acid concentration is associated with hyperhomocysteinemia in hypertensive Chinese adults.
Topics: Adult; Blood Pressure; China; Cholesterol; Creatinine; Humans; Hyperhomocysteinemia; Hypertension; R | 2022 |
Effects of uric acid-lowering therapy in patients with essential arterial hypertension.
Topics: Adult; Aged; Allopurinol; Blood Pressure; C-Reactive Protein; Carotid Intima-Media Thickness; Essent | 2022 |
Poorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio: a cross-sectional cohort study.
Topics: Blood Pressure; Cholesterol; Cross-Sectional Studies; Humans; Hypertension; Retrospective Studies; U | 2022 |
Chronic Kidney Disease and Left Ventricular Hypertrophy. Potent Modifiers of the Prognostic Impact of Circadian Blood Pressure Changes.
Topics: Bayes Theorem; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Huma | 2022 |
Dyslipidemia may be a risk factor for progression in children with IgA nephropathy.
Topics: Child; Disease Progression; Dyslipidemias; Glomerular Filtration Rate; Glomerulonephritis, IGA; Huma | 2022 |
Cardiovascular risk factors, ethnicity and infection stone are independent factors associated with reduced renal function in renal stone formers.
Topics: Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus; Ethnicity; Female; Gout; Heart | 2022 |
A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Calcium; Child, Preschool; Cross-Sectional Studies; Female; Humans | 2022 |
The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia.
Topics: Adult; Biomarkers; Blood Glucose; Body Mass Index; Glucose; Humans; Hypertension; Hyperuricemia; Ins | 2022 |
Serum Uric Acid Levels and Cardiometabolic Profile in Middle-Aged, Treatment-Naïve Hypertensive Patients.
Topics: Adult; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Meta | 2022 |
Metabolic syndrome in calcium oxalate stones: Is it so important in this type of lithiasis?
Topics: Calcium Oxalate; Estradiol; Female; Glucose; Humans; Hypertension; Lithiasis; Male; Metabolic Syndro | 2022 |
Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case-control study using data from the UK Biobank.
Topics: Alcohol Drinking; Biological Specimen Banks; Case-Control Studies; Genetic Predisposition to Disease | 2022 |
Effectiveness and safety of sacubitril/valsartan for patients with hypertension and heart failure in the real-world setting: A retrospective study in China.
Topics: Adult; Aminobutyrates; Angiotensin Receptor Antagonists; Biphenyl Compounds; Creatinine; Drug Combin | 2022 |
Relationship between lifestyle factors and hypertension: a cross-sectional analysis from the Gubbio study.
Topics: Adult; Blood Glucose; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Life St | 2023 |
Association between serum uric acid and arterial stiffness in a large-aged 40-70 years old population.
Topics: Adult; Aged; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; Hypertension; Male; M | 2022 |
Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh.
Topics: Bangladesh; Brain Ischemia; Cholesterol; Cross-Sectional Studies; Hospitals; Humans; Hypertension; H | 2022 |
Relationship between serum uric acid and hypertension in patients with primary Sjögren's syndrome: A retrospective cohort study.
Topics: Humans; Hypertension; Hyperuricemia; Retrospective Studies; Risk Factors; Sjogren's Syndrome; Uric A | 2022 |
The reality of treatment for hyperuricemia and gout in Japan: A historical cohort study using health insurance claims data.
Topics: Cohort Studies; Gout; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Insurance, Health; Jap | 2022 |
Hyperuricemia and risk of hypertension resistant to therapy: a systematic review and meta-analysis: Erratum.
Topics: Humans; Hypertension; Hyperuricemia; Medical History Taking; Risk Factors; Uric Acid | 2022 |
Correlation between 24-Hour Ambulatory Blood Pressure Variability and White Matter Lesions in Patients with Cerebral Small Vascular Disease: A Cross-Sectional Study.
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cerebrovascular Disorders; Cross-Sectional St | 2022 |
The role of obesity, type 2 diabetes, and metabolic factors in gout: A Mendelian randomization study.
Topics: Diabetes Mellitus, Type 2; Genome-Wide Association Study; Gout; Humans; Hypertension; Mendelian Rand | 2022 |
Machine learning integration of multimodal data identifies key features of blood pressure regulation.
Topics: alpha-Linolenic Acid; Biomarkers; Blood Pressure; Carnitine; Chlorides; Creatinine; Humans; Hyperten | 2022 |
Demographic and clinical profile of black patients with chronic kidney disease attending a tertiary hospital in Johannesburg, South Africa.
Topics: Acidosis; Aged; Allopurinol; Anemia; Bicarbonates; Cross-Sectional Studies; Diabetes Mellitus; Doxaz | 2022 |
The Association Between Hypouricemia and Cardiometabolic Diseases: Analyzing Nationwide Data From Medical Checkup and Health Insurance Records.
Topics: Cross-Sectional Studies; Dyslipidemias; Female; Humans; Hypertension; Insurance, Health; Male; Purin | 2023 |
Uric acid and blood pressure in NHANES dated from 2009 to 2018: A cross-sectional research.
Topics: Blood Pressure; Blood Pressure Determination; Cross-Sectional Studies; Female; Humans; Hypertension; | 2022 |
Hyperuricaemia and its association with other risk factors for cardiovascular diseases: A population-based study.
Topics: Adolescent; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperuri | 2022 |
Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients.
Topics: Aged; Case-Control Studies; Fractals; Humans; Hypertension; Macula Lutea; Microvessels; Middle Aged; | 2023 |
Association of serum uric acid with the risk of developing hypertension: A prospective cohort study with mediation analysis.
Topics: China; Female; Humans; Hypertension; Male; Mediation Analysis; Prospective Studies; Risk Factors; Ur | 2023 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.
Topics: Animals; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Mice; Phenotype; Pre-Eclampsia | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension.
Topics: Female; Humans; Hypertension; Magnesium; Male; Nutrition Surveys; Telomere; Uric Acid | 2022 |
Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values.
Topics: Adult; Cardiovascular System; Creatinine; Female; Humans; Hypertension; Male; Prognosis; Uric Acid | 2023 |
Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values.
Topics: Adult; Cardiovascular System; Creatinine; Female; Humans; Hypertension; Male; Prognosis; Uric Acid | 2023 |
Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values.
Topics: Adult; Cardiovascular System; Creatinine; Female; Humans; Hypertension; Male; Prognosis; Uric Acid | 2023 |
Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values.
Topics: Adult; Cardiovascular System; Creatinine; Female; Humans; Hypertension; Male; Prognosis; Uric Acid | 2023 |
Association between nocturnal sleep duration and the risk of hyperuricemia among Chinese government employees: A cross-sectional study.
Topics: Cohort Studies; Cross-Sectional Studies; East Asian People; Female; Humans; Hypertension; Male; Obes | 2022 |
Association between nocturnal sleep duration and the risk of hyperuricemia among Chinese government employees: A cross-sectional study.
Topics: Cohort Studies; Cross-Sectional Studies; East Asian People; Female; Humans; Hypertension; Male; Obes | 2022 |
Association between nocturnal sleep duration and the risk of hyperuricemia among Chinese government employees: A cross-sectional study.
Topics: Cohort Studies; Cross-Sectional Studies; East Asian People; Female; Humans; Hypertension; Male; Obes | 2022 |
Association between nocturnal sleep duration and the risk of hyperuricemia among Chinese government employees: A cross-sectional study.
Topics: Cohort Studies; Cross-Sectional Studies; East Asian People; Female; Humans; Hypertension; Male; Obes | 2022 |
Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Uric Acid; Xanth | 2022 |
Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Uric Acid; Xanth | 2022 |
Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Uric Acid; Xanth | 2022 |
Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Uric Acid; Xanth | 2022 |
Serum copeptin as a biomarker of hypertension in children with obesity.
Topics: Biomarkers; Child; Humans; Hypertension; Obesity; Potassium; Sodium; Uric Acid | 2022 |
Uric acid relationships with lipid profile and adiposity indices: Impact of different hyperuricemic thresholds.
Topics: Adiposity; Body Mass Index; Humans; Hypertension; Hyperuricemia; Obesity; Obesity, Abdominal; Trigly | 2023 |
The lipid accumulation product (LAP) association with hyperuricemic hypertension in the China Health and Nutrition Survey: A cross-sectional study.
Topics: Adult; Body Mass Index; China; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperuricemia; | 2022 |
Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Humans; Hypertensio | 2023 |
The elevated visceral adiposity index increases the risk of hyperuricemia in Chinese hypertensive patients: A cross-sectional study.
Topics: Adiposity; Cross-Sectional Studies; East Asian People; Female; Humans; Hypertension; Hyperuricemia; | 2022 |
The relationship between leukocyte level and hypertension in elderly patients with hyperuricemia.
Topics: Aged; Cross-Sectional Studies; Endothelial Cells; Humans; Hypertension; Hyperuricemia; Interleukin-1 | 2022 |
Elevated serum leptin levels are associated with lower renal function among middle-aged and elderly adults in Taiwan, a community-based, cross-sectional study.
Topics: Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Kidney; Lepti | 2022 |
Association of the serum uric acid to creatinine ratio with metabolic syndrome in the middle age and older population in China.
Topics: Aged; Creatinine; Cross-Sectional Studies; Female; Humans; Hypertension; Metabolic Syndrome; Middle | 2022 |
Metabolic Dysfunction-Associated Fatty Liver Disease in Newly Diagnosed, Treatment-Naive Hypertensive Patients and Its Association with Cardiorenal Risk Markers.
Topics: Blood Pressure; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypertension; Kidney Diseases; Ma | 2023 |
The association among uric acid, microalbumin and estimated glomerular filtration rate in hypertensive patients: a case control study.
Topics: Adult; Case-Control Studies; Glomerular Filtration Rate; Humans; Hypertension; Hyperuricemia; Risk F | 2023 |
The effect of serum uric acid concentration on the severity of chronic congestive heart failure.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Heart Failure; Humans; Hypertension; Male; Middl | 2022 |
Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension.
Topics: Blood Pressure; Cross-Sectional Studies; East Asian People; Female; Humans; Hypertension; Male; Risk | 2023 |
Association of MPPED2 gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients with hypertension.
Topics: Antihypertensive Agents; Cardiovascular Diseases; Glomerular Filtration Rate; Humans; Hypertension; | 2023 |
Gender difference in the association between gout at diagnosis and metabolic syndrome in African population: a retrospective cohort study.
Topics: Aged; Cameroon; Female; Gout; Humans; Hypertension; Male; Metabolic Syndrome; Middle Aged; Obesity; | 2022 |
Risk Factors for Hyperuricemia or Gout in Men and Women: The Circulatory Risk in Communities Study (CIRCS).
Topics: Diabetes Mellitus; Female; Gout; Humans; Hypercholesterolemia; Hypertension; Hypertriglyceridemia; H | 2023 |
Concentration of serum uric acid in patients with Renal Artery Stenosis and Hypertension prEdict Future nephropathy and death: C-RASHEF study.
Topics: Adult; Humans; Hypertension; Kidney; Renal Artery Obstruction; Risk Factors; Uric Acid | 2023 |
Temporal relationship between hyperuricemia and hypertension and its impact on future risk of cardiovascular disease.
Topics: Blood Pressure; Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Risk Factors; Uric Aci | 2023 |
Distinct hyperuricemia trajectories are associated with different risks of incident diabetes: A prospective cohort study.
Topics: Adult; Diabetes Mellitus; Dyslipidemias; Humans; Hypertension; Hyperuricemia; Middle Aged; Obesity; | 2023 |
Association between dietary approaches to stop hypertension (DASH) diet and hyperuricemia among Chinese adults: findings from a nationwide representative study.
Topics: Adult; Diet; Dietary Approaches To Stop Hypertension; East Asian People; Humans; Hypertension; Hyper | 2023 |
Sex difference in the associations among risk factors with depression in a large Taiwanese population study.
Topics: Adult; Blood Pressure; Depression; Diabetes Mellitus; Female; Glycated Hemoglobin; Humans; Hypertens | 2023 |
Hypertension severity, apparent treatment resistant hypertension and hyperuricemia in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Male; R | 2023 |
Association between adherence to the Dietary Approaches to Stop Hypertension diet and serum uric acid.
Topics: Adult; Data Collection; Diet; Dietary Approaches To Stop Hypertension; Humans; Hypertension; Uric Ac | 2023 |
The Relationship between Uric Acid/Albumin Ratio and Carotid Intima-Media Thickness in Patients with Hypertension.
Topics: Atherosclerosis; C-Reactive Protein; Carotid Intima-Media Thickness; Humans; Hypertension; Inflammat | 2023 |
Association of serum uric acid levels with cardiovascular and all-cause mortality in hypertensive patients in China: a cohort study.
Topics: Cardiovascular Diseases; China; Cohort Studies; Female; Humans; Hypertension; Male; Prospective Stud | 2023 |
The effects of cardiometabolic factors on the association between serum uric acid and risk of all-cause mortality in adults with congestive heart failure.
Topics: Adult; Cardiovascular Diseases; Heart Failure; Humans; Hyperglycemia; Hypertension; Nutrition Survey | 2023 |
The relationship between anemia and hyperuricemia and hypertension in Korean adults: the Korea National Health and Nutrition Examination Survey 2016-2018.
Topics: Adult; Anemia; Female; Humans; Hypertension; Hyperuricemia; Male; Nutrition Surveys; Republic of Kor | 2023 |
Uric acid and left ventricular mass in prediction of cardiovascular risk-New insight from the URRAH study.
Topics: Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Hypertension; Hypertrophy, Left Ventric | 2023 |
The relationship between patients' kidney stone type and demographics in Israel: analysis of 10 K patients.
Topics: Calcium Oxalate; Calcium Phosphates; Cystine; Diabetes Mellitus; Female; Humans; Hypertension; Israe | 2023 |
Positive correlation between fatty liver index and hyperuricemia in hypertensive Chinese adults: a H-type hypertension registry study.
Topics: Adult; East Asian People; Female; gamma-Glutamyltransferase; Humans; Hypertension; Hyperuricemia; Ma | 2023 |
Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA).
Topics: Aged; Aged, 80 and over; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Prospective | 2023 |
Serum uric acid: a futile bystander in endothelial function?
Topics: Adult; Allantoin; Angiotensin II; Blood Pressure; Humans; Hypertension; Lysine; Male; Microcirculati | 2023 |
[Association between metabolism-related chronic disease combination and prevalence of non-alcoholic fatty liver disease in community residents in Shanghai].
Topics: Adult; Body Mass Index; China; Chronic Disease; Diabetes Mellitus; Female; Gout; Humans; Hyperlipide | 2023 |
An analysis of the associations of high-sensitivity C-reactive protein and uric acid with metabolic syndrome components in Korean adults by sex: a cross-sectional study using the Korea national health and nutrition examination survey 2016-2018.
Topics: Adult; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Hypertension; Hypertriglyceridem | 2023 |
Association between serum uric acid levels and peripheral artery disease in Chinese adults with hypertension.
Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; East Asian People; Female; Gout; Humans; Hy | 2023 |
Relationship between serum uric acid and hypertension in the general US population aged 20 years and older: A cross-sectional study based on NHANES 2007 to 2016.
Topics: Adult; Alcohol Drinking; Cross-Sectional Studies; Humans; Hypertension; Nutrition Surveys; Uric Acid | 2023 |
Associations of serum uric acid with cardiovascular disease risk factors: a retrospective cohort study in southeastern China.
Topics: Cardiovascular Diseases; China; Female; Humans; Hyperglycemia; Hypertension; Hyperuricemia; Male; Re | 2023 |
Prediction of renal and cardiometabolic outcomes in gout during urate-lowering therapy by sonography.
Topics: Gout; Gout Suppressants; Humans; Hypertension; Kidney; Prospective Studies; Uric Acid | 2023 |
Serum uric acid is independently associated with hypertension in patients with polymyositis and dermatomyositis.
Topics: Cross-Sectional Studies; Dermatomyositis; Humans; Hypertension; Polymyositis; Uric Acid | 2023 |
Central diastolic blood pressure, plasma aldosterone and uric acid are associated with microalbuminuria in essential hypertension: a case-control study.
Topics: Albuminuria; Aldosterone; Blood Pressure; Case-Control Studies; Essential Hypertension; Humans; Hype | 2023 |
Association of serum uric acid levels with benign prostatic hyperplasia in US men: results from NHANES 2005-2008.
Topics: Humans; Hypertension; Male; Nutrition Surveys; Prostatic Hyperplasia; Risk Factors; United States; U | 2023 |
Sex-related differences for uric acid in the prediction of cardiovascular events in essential hypertension. A population prospective study.
Topics: Essential Hypertension; Female; Humans; Hypertension; Male; Prospective Studies; Risk Factors; Sex C | 2023 |
Uric acid and evaluate the coronary vascular stenosis gensini score correlation research and in gender differences.
Topics: Aged; C-Reactive Protein; Constriction, Pathologic; Coronary Angiography; Coronary Artery Disease; C | 2023 |
Association between serum uric acid/high-density lipoprotein cholesterol ratio and hypertension among reproductive-aged women.
Topics: Adult; Cholesterol, HDL; Cross-Sectional Studies; Female; Humans; Hypertension; Nutrition Surveys; U | 2023 |
Factors Affecting Mortality in Elderly Hypertensive Hospitalized Patients with COVID-19: A Retrospective Study.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; COVID-19; Frailty; Hospital Mortality; Humans; Hyperte | 2023 |
Gender differences in the association of serum uric acid with left ventricular hypertrophy should be focused.
Topics: Humans; Hypertension; Hypertrophy, Left Ventricular; Risk Factors; Sex Factors; Uric Acid | 2024 |
Role of immune system in development and progress of combined arterial hypertension and gout.
Topics: Arthritis, Gouty; Gout; Humans; Hypertension; Immune System; Male; Middle Aged; Uric Acid | 2019 |
Serum Creatinine and Occurrence and Severity of Coronary Artery Disease.
Topics: Adult; Aged; Apolipoprotein A-I; Biomarkers; Case-Control Studies; Cholesterol, HDL; Coronary Diseas | 2019 |
Metabolic Features of Individuals with Obesity Referred for Bariatric and Metabolic Surgery: a Cohort Study.
Topics: Adolescent; Adult; Aged; Bariatric Surgery; Biomarkers; C-Peptide; Cohort Studies; Cross-Sectional S | 2019 |
The challenges of managing gout in primary care: Results of a best-practice audit.
Topics: Aged; Allopurinol; Clinical Audit; Clinical Chemistry Tests; Clinical Protocols; Colchicine; Comorbi | 2019 |
Association between serum uric acid and chronic kidney disease in patients with hypertension: A multicenter nationwide cross-sectional study.
Topics: Aged; Arthritis, Gouty; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Pr | 2019 |
Could uric acid reduction by specific xanthine oxidase inhibition improve vascular function and reduce cardiovascular risk?
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Nitriles; Pyridines; Risk Factors; Uri | 2019 |
Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Hypertension; Italy; Male; Middle Aged; | 2020 |
The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats.
Topics: Adipose Tissue; Animals; Diglycerides; Energy Intake; Fagopyrum; Gastrointestinal Microbiome; Hypert | 2020 |
Clinical efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia.
Topics: Aged; Benzbromarone; Blood Pressure; Drug-Related Side Effects and Adverse Reactions; Female; Humans | 2019 |
Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men.
Topics: Adult; Blood Pressure; Body Mass Index; C-Reactive Protein; Humans; Hypertension; Insulin Resistance | 2020 |
Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism.
Topics: Actins; Animals; Cardiovascular Diseases; Carrier Proteins; Cell Line; Cell Proliferation; China; Hu | 2019 |
Association between atherogenic index of plasma and subclinical renal damage over a 12-year follow-up: Hanzhong adolescent hypertension study.
Topics: Adolescent; Atherosclerosis; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Hypertensio | 2020 |
Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study.
Topics: Adolescent; Adult; Biomarkers; Child; China; Cohort Studies; Creatinine; Cross-Sectional Studies; Di | 2019 |
Burden and management of gout in a multi-ethnic Asian cohort.
Topics: Adult; Aged; Allopurinol; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Dyslipidemias; Em | 2020 |
Hyperuricemia predicts the risk for developing hypertension independent of alcohol drinking status in men and women: the Saku study.
Topics: Adult; Aged; Alcohol Drinking; Female; Humans; Hypertension; Hyperuricemia; Incidence; Japan; Male; | 2020 |
Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study.
Topics: Aged; Blood Pressure; Cohort Studies; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged | 2020 |
Uric Acid and Potassium Serum Levels Are Independent Predictors of Blood Pressure Non-Dipping in Overweight or Obese Subjects.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carotid Intima-Media Thickness; | 2019 |
Microalbuminuria mediates the association between serum uric acid and elevation of blood pressure: a longitudinal analysis in the Gusu cohort.
Topics: Adult; Albuminuria; Asian People; Blood Glucose; Blood Pressure; Cohort Studies; Female; Humans; Hyp | 2020 |
The influence of uric acid level on erythrocyte morphology in normotensive patients.
Topics: Blood Pressure; Erythrocytes; Female; Humans; Hypertension; Hyperuricemia; Male; Uric Acid | 2019 |
Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; China; Diabetes | 2019 |
A Study of Serum Uric Acid Level in Essential Hypertension.
Topics: Essential Hypertension; Humans; Hypertension; Uric Acid | 2020 |
The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study.
Topics: Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studies; Dyslipidemias; Female; Gout; Humans; Hy | 2020 |
Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Creatinine; Disease Models, Animal; Diuresis; Hype | 2020 |
Uric acid and its correlation with hypertension in postmenopausal women: A multi-ethnic study (Observational study).
Topics: Body Mass Index; China; Cross-Sectional Studies; Ethnicity; Female; Glomerular Filtration Rate; Huma | 2020 |
Sex-specific association of hyperuricemia with cardiometabolic abnormalities in a military cohort: The CHIEF study.
Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Humans; Hypertension; Hypertriglyceridemia; Hype | 2020 |
Reactivity of salivary uric acid in response to social evaluative stress in African Americans.
Topics: Adolescent; Adult; Black or African American; Blood Pressure; Female; Humans; Hypertension; Male; Mi | 2020 |
Impact of Uric Acid on Hypertension Occurrence and Target Organ Damage: Insights From the STANISLAS Cohort With a 20-Year Follow-up.
Topics: Adult; Aged; Albuminuria; Blood Pressure; Cohort Studies; Creatinine; Female; France; Glomerular Fil | 2020 |
Understanding the Complex Interaction Between Uric Acid and Hypertension.
Topics: Blood Pressure; Cohort Studies; Follow-Up Studies; Humans; Hypertension; Uric Acid | 2020 |
The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study.
Topics: Age Factors; Aged; Biomarkers; Blood Pressure; China; Cross-Sectional Studies; Female; Humans; Hyper | 2020 |
Association of Impaired Renal Function With Changes in Urinary Mineral Excretion and Stone Composition.
Topics: Adult; Calcium; Calcium Oxalate; Calcium Phosphates; Citric Acid; Creatinine; Diabetes Mellitus; Dis | 2020 |
Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis.
Topics: Animals; Cerebral Hemorrhage; Humans; Hypertension; Intracranial Hemorrhage, Hypertensive; MAP Kinas | 2020 |
Associations between changes in serum uric acid and the risk of myocardial infarction.
Topics: Humans; Hypertension; Hyperuricemia; Middle Aged; Myocardial Infarction; Risk Factors; Uric Acid | 2020 |
Association of circulating uric acid and angiotensin-(1-7) in relation to higher blood pressure in adolescents and the influence of preterm birth.
Topics: Adolescent; Angiotensin I; Angiotensin II; Blood Pressure; Cross-Sectional Studies; Female; Humans; | 2020 |
Urate-lowering therapy exerts protective effects against hypertension development in patients with gout.
Topics: Aged, 80 and over; Gout; Gout Suppressants; Humans; Hypertension; Retrospective Studies; Uric Acid | 2021 |
Arterial hypertension associated with hyperuricemia: features of heart damage.
Topics: Heart Injuries; Humans; Hypertension; Hypertrophy, Left Ventricular; Hyperuricemia; Uric Acid | 2020 |
Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia.
Topics: Aged; Asymptomatic Diseases; Biomarkers; Blood Pressure; Databases, Factual; Diastole; Disease Progr | 2020 |
The differential role of uric acid - The purpose or cause of cardiovascular diseases?
Topics: Antioxidants; Biomarkers; Cardiovascular Diseases; Female; Humans; Hypertension; Oxidative Stress; R | 2020 |
Evaluation of Serum Uric Acid and Serum Creatinine in Male Hypertensive Patients.
Topics: Adult; Aged; Bangladesh; Creatinine; Cross-Sectional Studies; Humans; Hypertension; Male; Middle Age | 2020 |
Uric acid and hypertension.
Topics: Humans; Hypertension; Hyperuricemia; Uric Acid | 2020 |
Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study.
Topics: Cohort Studies; Heart Failure; Humans; Hypertension; Italy; Risk Factors; Uric Acid | 2021 |
High serum uric acid is associated with increased arterial stiffness in hypertension.
Topics: Adult; Aged; Ankle Brachial Index; Asian People; Cross-Sectional Studies; Female; Humans; Hypertensi | 2020 |
Higher baseline uric acid concentration is associated with non-attainment of optimal blood pressure.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus; Female; Humans; Hypertension; Logi | 2020 |
Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study.
Topics: Aged; Alanine Transaminase; Anthropometry; Blood Pressure; Blood Pressure Determination; Body Mass I | 2021 |
A pilot study to identify the longitudinal serum metabolite profiles to predict the development of hyperuricemia in essential hypertension.
Topics: Essential Hypertension; Humans; Hypertension; Hyperuricemia; Longitudinal Studies; Pilot Projects; U | 2020 |
Effects of luseogliflozin on arterial properties in patients with type 2 diabetes mellitus: The multicenter, exploratory LUSCAR study.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Diabetes Mellitus, | 2020 |
Uric Acid Is Not Associated With Blood Pressure Phenotypes and Target Organ Damage According to Blood Pressure Phenotypes.
Topics: Albuminuria; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Correla | 2021 |
Potential curing and beneficial effects of Ooitabi (Ficus pumila L.) on hypertension and dyslipidaemia in Okinawa.
Topics: Blood Pressure; Dyslipidemias; Ficus; Humans; Hypertension; Uric Acid | 2021 |
Evolution of isolated systolic hypertension with normal central blood pressure in adolescents-prospective study.
Topics: Adolescent; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Child; Female; Humans; Hypertensi | 2021 |
Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study.
Topics: Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; Female; Heart Disease Risk Factors | 2020 |
Subclinical Heart Dysfunction in Relation to Metabolic and Inflammatory Markers: A Community-Based Study.
Topics: Asymptomatic Diseases; Atrial Function, Left; Belgium; Biomarkers; Blood Glucose; Echocardiography, | 2021 |
Serum uric acid and left ventricular hypertrophy in hypertensive patients in Ado-Ekiti.
Topics: Aged; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Echocardiography; Female; Huma | 2020 |
Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study.
Topics: Adolescent; China; Cross-Sectional Studies; Disease Progression; Glomerular Filtration Rate; Humans; | 2021 |
Dental caries-related primary hypertension in children and adolescents: Cross-sectional study.
Topics: Adolescent; Blood Pressure; Child; Cross-Sectional Studies; Dental Caries; Humans; Hypertension; Uri | 2021 |
Association of Oral Status and Early Primary Hypertension Biomarkers among Children and Adolescents.
Topics: Adolescent; Biomarkers; Case-Control Studies; Child; Creatinine; Cystatin C; Dental Caries; DMF Inde | 2020 |
Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study.
Topics: Diuretics; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Risk Factors; Uric Acid | 2021 |
Risk Factors for Chronic Kidney Disease in Newly Diagnosed Hypertensive Subjects in Southeast Nigeria.
Topics: Cross-Sectional Studies; Humans; Hypertension; Nigeria; Prevalence; Renal Insufficiency, Chronic; Ri | 2020 |
Association between serum urate, gout and comorbidities: a case-control study using data from the UK Biobank.
Topics: Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Comorbidity; Diabetes Mellitus; Female; | 2021 |
Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; China; Cross-Sectional Studies; Female; Humans; Hyperten | 2021 |
Inter-relationship of risk factors and pathways associated with chronic kidney disease in patients with type 2 diabetes mellitus: a structural equation modelling analysis.
Topics: Adult; Aged; Biomarkers; Blood Pressure; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Ra | 2021 |
Relation of BMI and waist circumference with the risk of new-onset hyperuricemia in hypertensive patients.
Topics: Body Mass Index; China; Female; Humans; Hypertension; Hyperuricemia; Male; Risk Factors; Uric Acid; | 2022 |
The effect of baseline serum uric acid on chronic kidney disease in normotensive, normoglycemic, and non-obese individuals: A health checkup cohort study.
Topics: Adult; Aged; Blood Pressure; Body Mass Index; Cohort Studies; Diabetes Mellitus; Female; Glomerular | 2021 |
How do dietary interventions affect serum urate and gout?
Topics: Diet; Gout; Gout Suppressants; Humans; Hypertension; Uric Acid | 2021 |
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study.
Topics: Cardiovascular Diseases; Cardiovascular System; Cause of Death; Cohort Studies; Female; Follow-Up St | 2021 |
Elevated serum uric acid is associated with incident hypertension in the health according to various contemporary blood pressure guidelines.
Topics: Adult; Biomarkers; Blood Pressure; Blood Pressure Determination; Female; Humans; Hypertension; Hyper | 2021 |
Age and sex dependent association of uric acid and incident hypertension.
Topics: Adult; Age Factors; Aged; Biomarkers; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; I | 2021 |
[Association between serum uric acid and subclinical cardiac damage in children with primary hypertension].
Topics: Blood Pressure; Child; Humans; Hypertension; Hypertrophy, Left Ventricular; Retrospective Studies; U | 2021 |
Uric Acid Associates With Executive Function in Children and Adolescents With Hypertension.
Topics: Adolescent; Age Factors; Blood Pressure; Child; Executive Function; Female; Heart Disease Risk Facto | 2021 |
Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study.
Topics: Humans; Hypertension; Prehypertension; Prospective Studies; Risk Factors; Uric Acid | 2022 |
The URRAH study.
Topics: Diabetes Mellitus, Type 2; Gout; Heart Failure; Humans; Hypertension; Retrospective Studies; Stroke; | 2021 |
Association of hyperuricemia and hypertension phenotypes in hypertensive patients without uric acid lowering treatment.
Topics: Blood Pressure Monitoring, Ambulatory; Female; Humans; Hypertension; Hyperuricemia; Male; Phenotype; | 2021 |
Temporal relationship between body mass index and uric acid and their joint impact on blood pressure in children and adults: the Bogalusa Heart Study.
Topics: Adolescent; Adult; Blood Pressure; Body Mass Index; Child; Child, Preschool; Female; Humans; Hyperte | 2021 |
Tea consumption and serum uric acid levels among older adults in three large-scale population-based studies in China.
Topics: Aged; China; Cross-Sectional Studies; Humans; Hypertension; Tea; Uric Acid | 2021 |
[Uric acid in children and adolescents with primary hypertension].
Topics: Adolescent; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Child; Female; Humans; Hypertensi | 2021 |
Plasma uric acid is related to large arterial stiffness but not to other hemodynamic variables: a study in 606 normotensive and never-medicated hypertensive subjects.
Topics: Adult; Aged; Biomarkers; Blood Pressure; Cardiography, Impedance; Case-Control Studies; Cross-Sectio | 2021 |
Serum Urate Trajectory in Young Adulthood and Incident Cardiovascular Disease Events by Middle Age: CARDIA Study.
Topics: Adolescent; Adult; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hypertension; Inciden | 2021 |
A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease?
Topics: Female; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies | 2021 |
Association between elevated carotid intima-media thickness and serum uric acid levels among patients with essential hypertension in primary care setting in Sungai Buloh, Malaysia.
Topics: Carotid Arteries; Carotid Intima-Media Thickness; Cross-Sectional Studies; Essential Hypertension; H | 2021 |
Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication.
Topics: Female; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Male; Uric Acid; Xanthine Dehydroge | 2021 |
Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination.
Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Humans; Hydrochlorothiazide; Hypertensi | 2021 |
Association between Serum Uric Acid and Pre-hypertension and Hypertension among Chinese Adults.
Topics: Adult; China; Cross-Sectional Studies; Female; Humans; Hypertension; Prehypertension; Risk Factors; | 2021 |
Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study.
Topics: Adult; Cohort Studies; Female; Humans; Hypertension; Insulin Resistance; Male; Middle Aged; Prospect | 2022 |
J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities.
Topics: Adult; Aged; Blood Pressure; Cross-Sectional Studies; Humans; Hypertension; Male; Middle Aged; Preva | 2021 |
The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis.
Topics: Biomarkers; Blood Glucose; Body Mass Index; Dyslipidemias; Female; Follow-Up Studies; Glomerular Fil | 2021 |
Factors Influencing the Serum Uric Acid in Gout with Cerebral Infarction.
Topics: Cerebral Infarction; Cross-Sectional Studies; Gout; Humans; Hypertension; Uric Acid | 2021 |
Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
Topics: Adolescent; Blood Pressure; Cardiovascular Diseases; Child; Cholesterol; Cholesterol, HDL; Female; G | 2021 |
Association Between Serum Levels of Uric Acid and Blood Pressure Tracking in Childhood.
Topics: Age Factors; Biomarkers; Blood Pressure; Child; Child Development; Child, Preschool; Female; Humans; | 2017 |
Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study.
Topics: Blood Pressure; Child; Cohort Studies; Cross-Sectional Studies; Diastole; Female; Humans; Hypertensi | 2017 |
Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemia.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Child | 2017 |
Association of serum uric acid with increased risk of cancer among hypertensive Chinese.
Topics: Adult; Aged; Asian People; China; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Ag | 2017 |
An observational study on the relationship between serum uric acid and hypertension in a Northern Chinese population aged 45 to 59 years.
Topics: Anthropometry; Biomarkers; Blood Chemical Analysis; Blood Pressure Determination; China; Cross-Secti | 2017 |
Serum Uric Acid and Childhood Hypertension: Association to Causation to Prevention.
Topics: Blood Pressure; Blood Pressure Determination; Child; Humans; Hypertension; Uric Acid | 2017 |
Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study.
Topics: Aged; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Risk | 2017 |
Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort.
Topics: Aged; Blood Pressure; Brain Ischemia; China; Diastole; Female; Follow-Up Studies; Humans; Hypertensi | 2017 |
Interactive association of serum uric acid and total bilirubin with renal dysfunction among community-dwelling subjects.
Topics: Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Antihypertensive Agents; Bilirubin; Body Mas | 2017 |
Diet-independent relevance of serum uric acid for blood pressure in a representative population sample.
Topics: Adolescent; Adult; Aged; Blood Pressure; Cross-Sectional Studies; Diet; Dose-Response Relationship, | 2017 |
The ongoing role of serum uric acid in blood pressure.
Topics: Blood Glucose; Blood Pressure; Blood Pressure Determination; Body Mass Index; Cholesterol; Cluster A | 2017 |
Prospective direct comparison of antihypertensive effect and safety between high-dose amlodipine or indapamide in hypertensive patients uncontrolled by standard doses of angiotensin receptor blockers and amlodipine.
Topics: Aged; Aged, 80 and over; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biph | 2018 |
Association between serum uric acid level and hypertension in a Chinese elderly rural population.
Topics: Aged; Aged, 80 and over; Beijing; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertens | 2017 |
Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.
Topics: Animals; Biomarkers; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Creatinine; Diabetes Mellit | 2018 |
Effects of topiroxostat in hyperuricemic patients with chronic kidney disease.
Topics: Aged; Biomarkers; Blood Pressure; Enzyme Inhibitors; Female; Humans; Hypertension; Hyperuricemia; In | 2018 |
Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cyclooxygenase 2; Disease Models, Animal; Humans; Hypertension; Inflammatio | 2017 |
Chronological Trends in Clinical and Urinary Metabolic Features over 20 Years in Korean Urolithiasis Patients.
Topics: Age Factors; Body Mass Index; Calcium; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Inci | 2017 |
Chicken or the Egg? Hyperuricemia, Insulin Resistance, and Hypertension.
Topics: Humans; Hypertension; Hyperuricemia; Insulin Resistance; Uric Acid | 2017 |
Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure Determination; China; Cohort Studies; Female; Humans; Hyp | 2017 |
Cerebrovascular recovery after stroke with individual and combined losartan and captopril treatment of SHRsp.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anim | 2017 |
The Association of Uric Acid Calculi with Obesity, Prediabetes, Type 2 Diabetes Mellitus, and Hypertension.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middle Aged; Obesity; Prediabetic Sta | 2017 |
Serum Uric Acid Concentrations Can Predict Hypertension: A Longitudinal Population-Based Epidemiological Study.
Topics: Adult; Female; Follow-Up Studies; Humans; Hypertension; Incidence; Longitudinal Studies; Male; Middl | 2017 |
Augmented Association Between Blood Pressure and Proteinuria in Hyperuricemic Patients With Nonnephrotic Chronic Kidney Disease.
Topics: Adult; Antihypertensive Agents; Biomarkers; Blood Pressure; Cross-Sectional Studies; Female; Glomeru | 2018 |
Uric acid association with pulsatile and steady components of central and peripheral blood pressures.
Topics: Antihypertensive Agents; Arterial Pressure; Blood Pressure Determination; Central Venous Pressure; C | 2018 |
A comparative research on obesity hypertension by the comparisons and associations between waist circumference, body mass index with systolic and diastolic blood pressure, and the clinical laboratory data between four special Chinese adult groups.
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Bilirubin; Blood Glucose; Blood Pressure; B | 2018 |
Age, Body Mass Index, and Gender Predict 24-Hour Urine Parameters in Recurrent Idiopathic Calcium Oxalate Stone Formers.
Topics: Adolescent; Adult; Age Factors; Aged; Body Mass Index; Calcium; Calcium Oxalate; Calcium Phosphates; | 2017 |
Salivary uric acid and C-reactive protein associations with hypertension in Midwestern Latino preadolescents and their parents.
Topics: Adolescent; Adult; Biomarkers; C-Reactive Protein; Child; Female; Hispanic or Latino; Humans; Hypert | 2018 |
Sex-related relationships between uric acid and target organ damage in hypertension.
Topics: Adult; Aged; Carotid Artery Diseases; Carotid Intima-Media Thickness; Correlation of Data; Cross-Sec | 2018 |
Gender interaction of uric acid in the development of hypertension.
Topics: Adult; Aged; Blood Pressure; Female; Humans; Hypertension; Incidence; Japan; Longitudinal Studies; M | 2018 |
Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.
Topics: Adult; Age Factors; Aged; Blood Pressure; Body Mass Index; Cohort Studies; Disease Progression; Fema | 2018 |
Serum uric acid as a potential marker for heart failure risk in men on antihypertensive treatment: The British Regional Heart Study.
Topics: Aged; Antihypertensive Agents; Biomarkers; Cohort Studies; England; Follow-Up Studies; Heart Failure | 2018 |
Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome.
Topics: Adult; Aged; Amino Acids; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Mellitus; Dyslipidemi | 2017 |
The association of uric acid with the risk of metabolic syndrome, arterial hypertension or diabetes in young subjects- An observational study.
Topics: Adult; Age Factors; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Longit | 2018 |
Relationship between serum uric acid and blood pressure by adjusting dietary factors.
Topics: Blood Pressure; Blood Pressure Determination; Diet; Humans; Hypertension; Hyperuricemia; Uric Acid | 2018 |
Response to: Relationship between serum uric acid and blood pressure by adjusting dietary factors.
Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypertension; Hyperuricemia; Uric Acid | 2018 |
The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort.
Topics: Adult; Age Factors; Aged; China; Female; Healthy Volunteers; Humans; Hypertension; Male; Middle Aged | 2017 |
The Pathophysiology of Uric Acid on Renal Diseases.
Topics: Animals; Disease Models, Animal; Hemodynamics; Humans; Hypertension; Hyperuricemia; Kidney Diseases; | 2018 |
Renal Effects of Hyperuricemia.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Glomerular Filtration Rate; Humans; Hypertensi | 2018 |
Clinical Significance of Serum Uric Acid Levels in Mexican Young Adults.
Topics: Adolescent; Adult; Cholesterol, LDL; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Hu | 2018 |
Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study.
Topics: Adult; China; Female; Humans; Hypertension; Hyperuricemia; Incidence; Male; Middle Aged; Prospective | 2018 |
MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.
Topics: Adult; Arthritis; Autoimmune Diseases; Biological Specimen Banks; Celiac Disease; Female; Genetic Pr | 2018 |
Serum uric acid is associated with incidence of heart failure with preserved ejection fraction and cardiovascular events in patients with arterial hypertension.
Topics: Aged; Echocardiography, Doppler; Female; Heart Failure; Humans; Hypertension; Hyperuricemia; Inciden | 2018 |
Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out.
Topics: Blood Pressure; Guilt; Humans; Hypertension; Hyperuricemia; Male; Uric Acid | 2018 |
Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.
Topics: Aged; Antihypertensive Agents; DNA-Binding Proteins; Female; Finland; Genome-Wide Association Study; | 2018 |
Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.
Topics: Aged; Antihypertensive Agents; DNA-Binding Proteins; Female; Finland; Genome-Wide Association Study; | 2018 |
Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.
Topics: Aged; Antihypertensive Agents; DNA-Binding Proteins; Female; Finland; Genome-Wide Association Study; | 2018 |
Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.
Topics: Aged; Antihypertensive Agents; DNA-Binding Proteins; Female; Finland; Genome-Wide Association Study; | 2018 |
Relationship Between Serum Uric Acid and Incident Hypertension in Patients with Type 2 Diabetes.
Topics: Blood Pressure; Comorbidity; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Incidence; Ira | 2018 |
Developing and validating a new precise risk-prediction model for new-onset hypertension: The Jichi Genki hypertension prediction model (JG model).
Topics: Adult; Aged; Alcohol Drinking; Antihypertensive Agents; Blood Pressure; Body Mass Index; Cholesterol | 2018 |
Analysis on influencing factors of abnormal renal function in elderly patients with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Albuminuria; Blood Glucose; Cholesterol; Creatinine; Diabetes Mellitus, Typ | 2020 |
Single-marker and multi-marker approaches to appraise the relationships between biomarkers and microalbuminuria in Chinese middle-aged and elderly from communities: a cross-sectional analysis.
Topics: Aged; Aged, 80 and over; Albuminuria; Biomarkers; C-Reactive Protein; China; Cross-Sectional Studies | 2018 |
Urinary excretion of uric acid is negatively associated with albuminuria in patients with chronic kidney disease: a cross-sectional study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albuminuria; China; Cross-Sectional Studies; Female; Hum | 2018 |
Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities.
Topics: Adult; Aged; Black or African American; Comorbidity; Female; Gout; Humans; Hypertension; Incidence; | 2018 |
Impact of serum uric acid on incident hypertension in a worksite population of Japanese men.
Topics: Adolescent; Adult; Follow-Up Studies; Humans; Hypertension; Incidence; Japan; Male; Middle Aged; Ris | 2018 |
24-h urine metabolic profile: is it necessary in all kidney stone formers?
Topics: Adult; Aged; Body Mass Index; Calcium; Citric Acid; Comorbidity; Diabetes Mellitus; Female; Humans; | 2018 |
Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension.
Topics: Aged; Biomarkers; Carotid Intima-Media Thickness; Cross-Sectional Studies; Endothelium, Vascular; Fe | 2018 |
Is increased uric acid a risk factor or a defensive response? The Campania Salute Network.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Arterial Pressure; Biomarkers; | 2018 |
Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
Topics: Administration, Oral; Animals; Aorta; C-Reactive Protein; Human Umbilical Vein Endothelial Cells; Hu | 2018 |
Serum uric acid and arterial hypertension-Data from Sephar III survey.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickn | 2018 |
Involvement of Arterial Stiffness and Inflammation in Hyperuricemia-Related Development of Hypertension.
Topics: Adult; Ankle Brachial Index; Blood Pressure; C-Reactive Protein; Glomerular Filtration Rate; Humans; | 2018 |
Uric Acid and Hypertension Because of Arterial Stiffness.
Topics: Humans; Hypertension; Hyperuricemia; Inflammation; Uric Acid; Vascular Stiffness | 2018 |
Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aldosterone; Animals; Contraceptives, Oral, Com | 2018 |
The association of hyperuricemia and immediate postpartum hypertension in women without a diagnosis of chronic hypertension.
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Postpartum Period; Pregnancy; Ur | 2018 |
Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study.
Topics: Adult; Asian People; Beijing; Female; Humans; Hypertension; Longitudinal Studies; Male; Middle Aged; | 2018 |
Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the Blood Pressure control rate and CArdiovascular Risk profilE study.
Topics: Aged; Blood Pressure; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Europe, Eastern; Fema | 2019 |
Uric acid and early prevention of vascular diseases: Women under the looking glass.
Topics: Cross-Sectional Studies; Female; Humans; Hypertension; Uric Acid | 2018 |
Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Ind | 2018 |
Predictive markers of depression in hypertension.
Topics: Age Factors; Aged; Biomarkers; Blood Glucose; Blood Urea Nitrogen; Body Temperature; Case-Control St | 2018 |
The Association of Urinary Sodium and Potassium with Renal Uric Acid Excretion in Patients with Chronic Kidney Disease.
Topics: Adult; Aged; Cross-Sectional Studies; Epidermal Growth Factor; Female; Humans; Hypertension; Hyperur | 2018 |
Abdominal obesity and reduction of glomerular filtration.
Topics: Adult; Analysis of Variance; Anthropometry; Black People; Brazil; Cholesterol; Creatinine; Cross-Sec | 2018 |
Gender difference in the relationship between uric acid and pulse pressure among Korean adults.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperuricemia; Inciden | 2019 |
Effects of uric acid on vascular endothelial function from bedside to bench.
Topics: Aged; Aged, 80 and over; Blood Pressure; Cell Hypoxia; Cell Survival; Endothelium, Vascular; Female; | 2018 |
Uric Acid Treatment After Stroke Prevents Long-Term Middle Cerebral Artery Remodelling and Attenuates Brain Damage in Spontaneously Hypertensive Rats.
Topics: Animals; Antioxidants; Brain Injuries; Cerebral Revascularization; Hypertension; Infarction, Middle | 2020 |
Gender, subclinical organ damage and cardiovascular risk stratification in hypertensive patients.
Topics: Adult; Ankle Brachial Index; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Carotid In | 2019 |
High urate concentration is associated with elevated blood pressure in schoolchildren.
Topics: Adolescent; Blood Pressure; Brazil; Child; Cross-Sectional Studies; Female; Humans; Hypertension; Hy | 2018 |
Hypertension and Hyperuricemia: A Compelling Correlation.
Topics: Case-Control Studies; Humans; Hypertension; Hyperuricemia; India; Uric Acid | 2018 |
Should our approach to diuretic using in patients with gout change?
Topics: Diuretics; Gout; Humans; Hypertension; Uric Acid | 2018 |
Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans.
Topics: Adult; Black or African American; Blood Pressure; Cardiovascular Diseases; Female; Healthy Volunteer | 2019 |
Age-differential association between serum uric acid and incident hypertension.
Topics: Adult; Age Factors; Aged; Aging; Antihypertensive Agents; Asian People; Blood Pressure; Body Mass In | 2019 |
Antihypertensive Potential of Coenzyme Q10 via Free Radical Scavenging and Enhanced Akt-nNOS Signaling in the Nucleus Tractus Solitarii in Rats.
Topics: Animals; Antihypertensive Agents; Free Radical Scavengers; Fructose; Glucose Transporter Type 1; Hyp | 2019 |
Osteoporosis is inversely associated with arterial stiffness in the elderly: An investigation using the Osteoporosis Self-assessment Tool for Asians index in an elderly Chinese cohort.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Asian People; Body Mass Index; China; Cross-Sectional | 2019 |
Onset of Hypertension in Living Kidney Donors After Donor Nephrectomy: Our 20 Years of Experience.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Blood Pressure; Female; Glomerular Filtration Rate; Health S | 2019 |
Beneficial Effect of Dietary Fiber on Hyperuricemia in Rats and Humans: A Review.
Topics: Animals; Diet; Dietary Fiber; Humans; Hypertension; Hyperuricemia; Rats; Uric Acid | 2019 |
Interaction between low-density lipoprotein-cholesterolaemia, serum uric level and incident hypertension: data from the Brisighella Heart Study.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Determination; Cholesterol, LDL; Cohort Studies; Female; | 2019 |
Leukocyte matrix metalloproteinase and tissue inhibitor gene expression patterns in children with primary hypertension.
Topics: Adolescent; Child; Child, Preschool; Gene Expression; Humans; Hypertension; Leukocytes; Matrix Metal | 2020 |
Distinct Uric Acid Trajectories Are Associated With Different Risks of Incident Hypertension in Middle-Aged Adults.
Topics: Adult; Age Factors; Blood Pressure; Cohort Studies; Female; Humans; Hypertension; Male; Middle Aged; | 2019 |
Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu
Topics: Adolescent; Blood Pressure; Child; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephro | 2019 |
Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level.
Topics: Carotid Intima-Media Thickness; Humans; Hypertension; Lipids; Matrix Metalloproteinase 3; Pulse Wave | 2021 |
Serum Phosphate and the Risk of New-Onset Hyperuricemia in Hypertensive Patients.
Topics: Age Factors; Aged; Biomarkers; China; Comorbidity; Confidence Intervals; Double-Blind Method; Female | 2019 |
Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout.
Topics: Adult; Aged; Blood Pressure Determination; Chronic Disease; Dose-Response Relationship, Drug; Drug A | 2019 |
Relationship between carotid-femoral pulse wave velocity and uric acid in subjects with hypertension and hyperuricemia.
Topics: Aged; Carotid-Femoral Pulse Wave Velocity; Cross-Sectional Studies; Female; Humans; Hypertension; Hy | 2019 |
Stone composition and vascular calcifications in patients with nephrolithiasis.
Topics: Adult; Age Factors; Aged; Aorta, Abdominal; Calcium Phosphates; Cross-Sectional Studies; Diabetes Co | 2019 |
Added predictive value of high uric acid for cardiovascular events in the Ambulatory Blood Pressure International Study.
Topics: Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Cohort Studies; Correlation of Data; | 2019 |
Subclinical atherosclerosis due to increase of plasma aldosterone concentrations in essential hypertensive individuals.
Topics: Adult; Aldosterone; Ankle Brachial Index; Atherosclerosis; Biomarkers; Carotid Intima-Media Thicknes | 2019 |
Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study.
Topics: Adult; Aged; Aged, 80 and over; China; Cohort Studies; Cross-Sectional Studies; Female; Follow-Up St | 2019 |
Pulse wave velocity progression over a medium-term follow-up in hypertensives: Focus on uric acid.
Topics: Blood Pressure Monitoring, Ambulatory; Correlation of Data; Disease Progression; Female; Follow-Up S | 2019 |
Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults.
Topics: Adult; Bangladesh; Blood Pressure Determination; Cross-Sectional Studies; Female; Humans; Hypertensi | 2019 |
Effects of Prenatal Growth Status on Subsequent Childhood Renal Function Related to High Blood Pressure.
Topics: Blood Pressure; Blood Urea Nitrogen; Child; Cohort Studies; Cystatin C; Female; Glomerular Filtratio | 2019 |
Relationship of reduced glomerular filtration rate with alterations in plasma free amino acids and uric acid evaluated in healthy control and hypertensive subjects.
Topics: Adult; Amino Acids; Case-Control Studies; Cross-Sectional Studies; Female; Glomerular Filtration Rat | 2019 |
Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease.
Topics: Aged; Albuminuria; Biomarkers; Creatinine; Cystatin C; Diabetes Mellitus; Female; Glomerular Filtrat | 2013 |
Relationship between uric acid and vascular structure and function in hypertensive patients and sex-related differences.
Topics: Adult; Aged; Blood Pressure; Carotid Arteries; Carotid Intima-Media Thickness; Cross-Sectional Studi | 2013 |
Association of uric acid with obesity and endothelial dysfunction in children and early adolescents.
Topics: Adolescent; Area Under Curve; Asian People; Biomarkers; Blood Pressure; Body Composition; Body Mass | 2013 |
Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure.
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Blood Pressure Determination; Body Mass Index; Car | 2013 |
What are the key arguments against uric acid as a true risk factor for hypertension?
Topics: Animals; Blood Pressure; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Kidney; Risk F | 2013 |
Urinary angiotensinogen as a marker of intrarenal angiotensin II activity in adolescents with primary hypertension.
Topics: Adolescent; Angiotensin II; Angiotensinogen; Biomarkers; Body Mass Index; Chi-Square Distribution; C | 2013 |
Serum uric acid still carries controversies about its role in endothelial dysfunction.
Topics: Circadian Rhythm; Female; Humans; Hypertension; Male; Uric Acid | 2013 |
REPLY TO: Serum uric acid still carries controversies about its role in endothelial dysfunction.
Topics: Circadian Rhythm; Female; Humans; Hypertension; Male; Uric Acid | 2013 |
Serum γ-glutamyltransferase and uric acid levels are associated with impaired fasting glucose in adults from Inner Mongolia, China.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; China; Cohort Studies; Cros | 2013 |
Is there any correlation between serum uric acid levels and right ventricular function parameters in patients with cardiovascular risk factors?
Topics: Blood Pressure; Carotid Arteries; Female; Femoral Artery; Humans; Hypertension; Male; Uric Acid; Vas | 2013 |
Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Disease Progression; Female; Follow-Up Studies; Glom | 2013 |
Serum uric acid and blood pressure in children at cardiovascular risk.
Topics: Adolescent; Age Factors; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Child; Cohort Stu | 2013 |
Increased uric acid promotes decline of the renal function in hypertensive patients: a 10-year observational study.
Topics: Aged; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Middle Aged; Uric Acid | 2013 |
Relationships of different blood pressure categories to indices of inflammation and platelet activity in sustained hypertensive patients with uncontrolled office blood pressure.
Topics: Adult; Aged; Antihypertensive Agents; Biomarkers; Blood Pressure; Blood Pressure Determination; C-Re | 2013 |
Serum uric acid levels among Nigerians with essential hypertension.
Topics: Case-Control Studies; Humans; Hypertension; Nigeria; Retrospective Studies; Uric Acid | 2013 |
Relationship between metabolic syndrome and diagnoses of periodontal diseases among participants in a large Taiwanese cohort.
Topics: Adult; Blood Glucose; Body Mass Index; C-Reactive Protein; Cholesterol, HDL; Cohort Studies; Creatin | 2013 |
Factors related with the progression of chronic kidney disease.
Topics: Aged; Anemia; Calcium; Chronic Disease; Chronic Kidney Disease-Mineral and Bone Disorder; Diabetic N | 2013 |
A gender-specific analysis of association between hyperuricaemia and cardiovascular events in patients with coronary artery disease.
Topics: Aged; Aged, 80 and over; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Dis | 2013 |
Serum uric acid level is associated with the development of microalbuminuria in Korean men.
Topics: Adult; Age Factors; Albuminuria; Asian People; Cohort Studies; Creatinine; Diabetes Complications; D | 2014 |
Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: a hospital based cross sectional study.
Topics: Adult; Aged; Cross-Sectional Studies; Essential Hypertension; Female; Humans; Hypertension; Hyperuri | 2014 |
A new and fast methodology to assess oxidative damage in cardiovascular diseases risk development through eVol-MEPS-UHPLC analysis of four urinary biomarkers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Calibration; Case-Control Studies; Chromatography, H | 2013 |
Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study.
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Diabetes Mel | 2013 |
Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate.
Topics: Animals; Base Sequence; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; DNA Primers; Hypert | 2014 |
Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study.
Topics: Adult; Atherosclerosis; Female; Humans; Hypertension; Italy; Male; Metabolic Syndrome; Middle Aged; | 2014 |
Serum uric acid concentration and asymptomatic hyperuricemia with subclinical organ damage in general population.
Topics: Aged; Aged, 80 and over; Albuminuria; Biomarkers; Cross-Sectional Studies; Humans; Hypertension; Hyp | 2014 |
Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population.
Topics: Adult; Antihypertensive Agents; Asian People; Biomarkers; Blood Pressure; Chi-Square Distribution; F | 2014 |
Serum uric acid and new-onset hypertension: a possible therapeutic avenue?
Topics: Asian People; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Male; Uric Acid | 2014 |
Uric acid level and erectile dysfunction in patients with coronary artery disease.
Topics: Aged; C-Reactive Protein; Coronary Artery Disease; Cross-Sectional Studies; Diabetes Mellitus; Erect | 2014 |
High prevalence and risk factors for kidney dysfunction in patients with atherosclerotic cardio-cerebrovascular disease.
Topics: Age Factors; Aged; Aged, 80 and over; Atherosclerosis; Cerebrovascular Disorders; China; Coronary Di | 2014 |
Serum uric acid concentration and asymptomatic hyperuricemia.
Topics: Albuminuria; Humans; Hypertension; Hyperuricemia; Male; Uric Acid; Vascular Stiffness | 2014 |
Q: should patients with gout avoid thiazides for hypertension?
Topics: Contraindications; Gout; Gout Suppressants; Humans; Hypertension; Thiazides; Uric Acid | 2014 |
Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Blood P | 2014 |
Reply to letter to the editor from Professor Viroj Wiwanitkit, Bankok, Thailand.
Topics: Albuminuria; Humans; Hypertension; Hyperuricemia; Male; Uric Acid; Vascular Stiffness | 2014 |
Serum uric acid levels are associated with high blood pressure in Chinese children and adolescents aged 10-15 years.
Topics: Adolescent; Child; China; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Uric Acid | 2014 |
Serum uric acid as a risk predictor for erectile dysfunction.
Topics: Biomarkers; Cardiovascular Diseases; Case-Control Studies; Confidence Intervals; Erectile Dysfunctio | 2014 |
Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010.
Topics: Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperu | 2014 |
Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis.
Topics: Animals; Arterial Pressure; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Human Umbilical Ve | 2014 |
Blood pressure and uric acid in diabetes mellitus.
Topics: Blood Pressure; Diabetes Mellitus, Type 1; Female; Humans; Hypertension; Male; Uric Acid | 2014 |
Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes.
Topics: Adult; Blood Pressure; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabe | 2014 |
Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension.
Topics: Adult; Asian People; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperuri | 2014 |
Atorvastatin combining with probucol: a new way to reduce serum uric acid level during perioperative period of interventional procedure.
Topics: Acute Kidney Injury; Aged; Antioxidants; Atorvastatin; Biomarkers; Contrast Media; Drug Therapy, Com | 2014 |
Serum uric acid and its relationship with metabolic syndrome and cardiovascular risk profile in patients with hypertension: insights from the I-DEMAND study.
Topics: Aged; Albuminuria; Biomarkers; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Cross-Secti | 2014 |
Relationships between mild hyperuricaemia and aortic stiffness in untreated hypertensive patients.
Topics: Adult; Albuminuria; Aorta; Body Mass Index; Cross-Sectional Studies; Female; Humans; Hypertension; H | 2014 |
Prognostic value of serum uric acid: new-onset in and out-of-office hypertension and long-term mortality.
Topics: Adult; Aged; Anthropometry; Blood Pressure; Blood Pressure Determination; Blood Pressure Monitoring, | 2014 |
Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Fructose; Hypertension; Insul | 2014 |
Association of serum uric acid with level of blood pressure in type 2 diabetic patients.
Topics: Aged; Biomarkers; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; | 2014 |
Serum uric acid and target organ damage in essential hypertension.
Topics: Adult; Aged; Albuminuria; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Female; Humans; | 2014 |
Effects of insulin resistance on left ventricular hypertrophy in patients with CKD stage 1-3.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; C-Re | 2014 |
Prevention of comorbidity and acute attack of gout by uric acid lowering therapy.
Topics: Adult; Allopurinol; Antimetabolites; Benzbromarone; Cardiovascular Diseases; Comorbidity; Diabetes M | 2014 |
Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
Topics: Animals; Creatinine; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; | 2014 |
Blood lipid profile and BMI-Z-score in adolescents with hyperuricemia.
Topics: Adolescent; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypertension; Hyper | 2015 |
Relationship between serum uric acid levels and hepatic steatosis in non-obese postmenopausal women.
Topics: Adult; Aged; Blood Pressure; Body Mass Index; China; Cross-Sectional Studies; Diabetes Mellitus, Typ | 2014 |
Serum uric acid and arterial stiffness in hypertensive chronic kidney disease patients: sex-specific variations.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Comorbidity; C | 2014 |
Gender difference in the association of hyperuricemia with hypertension in a middle-aged Chinese population.
Topics: Asian People; Body Mass Index; China; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperur | 2014 |
Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes.
Topics: Adult; Aged; Altitude; Biomarkers; Dyslipidemias; Female; gamma-Glutamyltransferase; Hemoglobins; Hu | 2015 |
Relationship between elevated morning blood pressure surge, uric acid, and cardiovascular outcomes in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular System; Circadian | 2014 |
Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension.
Topics: Adipose Tissue; Adult; Angiotensinogen; Body Mass Index; Case-Control Studies; China; Homeostasis; H | 2014 |
Hypertension and obesity: correlates with renin-angiotensin-aldosterone system and uric acid.
Topics: Angiotensinogen; Humans; Hypertension; Male; Obesity; Uric Acid | 2014 |
Hyperuricemia and incident atrial fibrillation in a normotensive elderly population in Taiwan.
Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Blood Pressure; Electrocardiography; Female; Follow-Up | 2014 |
Increased risk of acute coronary syndrome among patients with urinary stone disease: a nationwide population-based cohort study.
Topics: Acute Coronary Syndrome; Adult; Age Factors; Aged; Cohort Studies; Diabetes Mellitus; Female; Humans | 2014 |
Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males.
Topics: Aged; Blood Pressure; Brain; C-Reactive Protein; Carotid Intima-Media Thickness; Cerebrovascular Dis | 2014 |
The relationship between uric acid and erectile dysfunction in hypertensive subjects.
Topics: Adult; Aged; Blood Pressure; Cross-Sectional Studies; Erectile Dysfunction; Humans; Hypertension; Ma | 2014 |
Development of albuminuria and enhancement of oxidative stress during chronic renin-angiotensin system suppression.
Topics: Aged; Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bioma | 2014 |
Simultaneous determination of plasma creatinine, uric acid, kynurenine and tryptophan by high-performance liquid chromatography: method validation and in application to the assessment of renal function.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Female; Humans; Hypertension; Kidney | 2015 |
Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Caffeine; Camellia sinensis; Epinephrine; Hypertension; Male; Norepinephrin | 2015 |
Attenuating the mortality risk of high serum uric acid: the role of physical activity underused.
Topics: Adult; Aged; Asymptomatic Diseases; Cause of Death; Cohort Studies; Diabetes Mellitus; Exercise; Fem | 2015 |
Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity.
Topics: Aged; Body Composition; Body Mass Index; Cohort Studies; Female; Humans; Hypertension; Indians, Nort | 2014 |
[Clinical value of the determination of markers for endothelial dysfunction (endothelin-1, microalbuminuria) and tubulointerstitial tissue lesion (β2-microglobulin, monocyte chemotactic protein-1) in hypertensive patients with uric acid metabolic disorder
Topics: Albuminuria; beta 2-Microglobulin; Biomarkers; Chemokine CCL2; Comorbidity; Endothelin-1; Endotheliu | 2014 |
Allopurinol initiation and change in blood pressure in older adults with hypertension.
Topics: Age Factors; Aged; Allopurinol; Blood Pressure; Case-Control Studies; Databases, Factual; Dose-Respo | 2014 |
[Gender and subclinical vascular organ damage in patients with coronary artery disease and/or hypertension].
Topics: Ankle Brachial Index; Carotid Intima-Media Thickness; Comorbidity; Coronary Disease; Female; Hemodyn | 2014 |
[Uric acid and factors of cardiometabolic risk in adolescents with arterial hypertension].
Topics: Adolescent; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Glucose; Heart Diseases; Humans; | 2014 |
Association of uric acid genetic risk score with blood pressure: the Rotterdam study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Cohort Studies; Diuretics; Female; Genetic Variation; | 2014 |
Uricaemia and left ventricular mass in hypertensive patients.
Topics: Blood Glucose; Cross-Sectional Studies; Echocardiography; Female; Humans; Hypertension; Hypertrophy, | 2014 |
The validation of a diagnostic rule for gout without joint fluid analysis: a prospective study.
Topics: Aged; Cardiovascular Diseases; Decision Support Techniques; Erythema; Female; Gout; Humans; Hyperten | 2015 |
Serum uric acid and disorders of glucose metabolism: the role of glycosuria.
Topics: Adult; Age Factors; Blood Glucose; Brazil; Community Health Services; Comorbidity; Cross-Sectional S | 2014 |
Association between serum uric acid and mortality in a Chinese population of hypertensive patients.
Topics: Aged; Cause of Death; China; Female; Humans; Hypertension; Hyperuricemia; Incidence; Male; Middle Ag | 2015 |
Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh.
Topics: Adolescent; Adult; Arsenic; Arsenic Poisoning; Bangladesh; Biomarkers; Cross-Sectional Studies; Drin | 2014 |
Soluble ligand CD40 and uric acid as markers of atheromatosis in patients with obstructive sleep apnea.
Topics: Adult; Atherosclerosis; Biomarkers; Case-Control Studies; CD40 Ligand; Female; Humans; Hypertension; | 2015 |
Uric acid levels and the risk of Contrast Induced Nephropathy in patients undergoing coronary angiography or PCI.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Diseases; Choleste | 2015 |
Nephron hypertrophy and glomerulosclerosis and their association with kidney function and risk factors among living kidney donors.
Topics: Adult; Age Factors; Albuminuria; Body Mass Index; Female; Glomerular Filtration Rate; Glomeruloscler | 2014 |
[Correlation between lacunar cerebral infarction and serum uric acid level in elderly male hypertension patients].
Topics: Aged, 80 and over; Cerebral Infarction; Humans; Hypertension; Male; Regression Analysis; Risk Factor | 2014 |
Influence of urate-lowering therapies on renal handling of uric acid.
Topics: Adult; Antihypertensive Agents; Benzbromarone; Case-Control Studies; Creatinine; Glomerular Filtrati | 2016 |
Associations between serum uric acid levels and the incidence of hypertension and metabolic syndrome: a 4-year follow-up study of a large screened cohort in Okinawa, Japan.
Topics: Adult; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Humans; Hypertension; Incidence; Japan | 2015 |
Hyperuricemia in patients with chronic plaque psoriasis.
Topics: Adult; Body Mass Index; Female; Humans; Hypertension; Hyperuricemia; Italy; Male; Middle Aged; Obesi | 2014 |
Serum uric acid levels are associated with hypertension and metabolic syndrome but not atherosclerosis in Chinese inpatients with type 2 diabetes.
Topics: Aged; Asian People; Atherosclerosis; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cross- | 2015 |
Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease.
Topics: Adolescent; Blood Pressure Determination; Chi-Square Distribution; Child; Child, Preschool; Choleste | 2014 |
Relationship between red cell distribution width and serum uric acid in patients with untreated essential hypertension.
Topics: Cross-Sectional Studies; Erythrocyte Count; Erythrocytes; Essential Hypertension; Female; Humans; Hy | 2014 |
[Atypical risk factors of atherosclerosis in patients with hypothyroidism].
Topics: Adult; Aged; Atherosclerosis; Biomarkers; Body Mass Index; C-Reactive Protein; Carotid Arteries; Fem | 2013 |
Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study.
Topics: Aged; Aged, 80 and over; Asian People; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; C | 2015 |
[Serum uric acid levels and risk of developing preeclampsia].
Topics: Adult; Birth Weight; Creatinine; Early Diagnosis; Female; Humans; Hypertension; Infant, Low Birth We | 2014 |
Plasma aldosterone and its relationship with left ventricular mass in hypertensive patients with early-stage chronic kidney disease.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Creatinine; Female; Humans; Hypertension; Hypertrophy, Lef | 2015 |
[Relationship between hyperuricemia and primary nephrotic syndrome in children].
Topics: Child; Creatinine; Humans; Hypertension; Hyperuricemia; Nephrotic Syndrome; Retrospective Studies; U | 2014 |
Clinical risk factors of prediabetes in Taiwanese women without substance uses (tobacco, alcohol, or areca nut).
Topics: Adult; Age Factors; Alanine Transaminase; Alcohol Drinking; Areca; Body Mass Index; Cholesterol; Fem | 2015 |
Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease.
Topics: Adult; Asian People; China; Coronary Angiography; Coronary Artery Disease; Echocardiography; Female; | 2015 |
Serum uric acid and non-alcoholic fatty liver disease in non-hypertensive Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study.
Topics: Adult; Asian People; Biomarkers; China; Female; Humans; Hypertension; Male; Non-alcoholic Fatty Live | 2015 |
The relationship between vascular inflammation and target organ damage in hypertensive crises.
Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chemokine CCL2; Emergency Service, Ho | 2015 |
Uric acid may cause of erectile dysfunction in hypertensive patients?
Topics: Erectile Dysfunction; Humans; Hypertension; Male; Uric Acid | 2015 |
Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients.
Topics: Adult; Female; Gout; Humans; Hypertension; Hyperuricemia; Insulin Resistance; Kidney; Male; Middle A | 2015 |
[Not Available].
Topics: Erectile Dysfunction; Humans; Hypertension; Male; Uric Acid | 2015 |
Uric Acid and Cardiovascular Events: A Mendelian Randomization Study.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Coronary Disease; Cross-Sectional Studies; Female; Follow | 2015 |
Serum uric acid: an independent predictive marker for coronary artery disease.
Topics: Coronary Artery Disease; Female; Humans; Hyperlipidemias; Hypertension; Male; Uric Acid | 2015 |
The association of metabolic syndrome and its components with brachial-ankle pulse wave velocity in south China.
Topics: Adolescent; Adult; Aged; Ankle Brachial Index; Biomarkers; Blood Glucose; Blood Pressure; Cardiovasc | 2015 |
The association and interaction analysis of hypertension and uric acid on cardiovascular autonomic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Blood Glucose; Blood Pressure; Ca | 2015 |
The association and interaction analysis of hypertension and uric acid on cardiovascular autonomic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Blood Glucose; Blood Pressure; Ca | 2015 |
The association and interaction analysis of hypertension and uric acid on cardiovascular autonomic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Blood Glucose; Blood Pressure; Ca | 2015 |
The association and interaction analysis of hypertension and uric acid on cardiovascular autonomic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Blood Glucose; Blood Pressure; Ca | 2015 |
Does elevated serum uric acid level predict the hypertension incidence? A Chinese prospective cohort study.
Topics: Adult; Aged; Blood Pressure; China; Female; Follow-Up Studies; Humans; Hypertension; Hyperuricemia; | 2015 |
Association of hormone therapy and incident gout: population-based case-control study.
Topics: Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Body Mass Index; Case-Control Studies; Estro | 2015 |
Hyperuricaemia is associated with renal damage independently of hypertension and intrarenal renin-angiotensin system activation, as well as their circadian rhythms.
Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Angiotensinogen; Biomarkers; Blood Pressure; Circadian | 2015 |
The therapeutic advantage of combination antihypertensive drug therapy using amlodipine and irbesartan in hypertensive patients: Analysis of the post-marketing survey data from PARTNER (Practical combination therapy of Amlodin and angiotensin II Receptor
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Blood Pressure | 2015 |
[Metabolic complications of obesity during adolescence, particularly regarding elevated uric acid levels].
Topics: Adolescent; Biomarkers; Blood Pressure; Body Mass Index; Case-Control Studies; Child; Cross-Sectiona | 2015 |
Uric acid levels within the normal range predict increased risk of hypertension: a cohort study.
Topics: Adult; Aged; Biomarkers; Female; Follow-Up Studies; Humans; Hypertension; Hyperuricemia; Incidence; | 2015 |
Associations between blood pressure responses to acute stress and impaired renal function and serum uric acid level.
Topics: Acute Disease; Blood Pressure; Electrocardiography; Female; Glomerular Filtration Rate; Humans; Hype | 2015 |
Uric acid blood levels and relationship with the components of metabolic syndrome in hypertensive patients.
Topics: Adult; Aged; Apolipoprotein A-I; Apolipoprotein B-100; Biomarkers; Blood Glucose; Blood Pressure; Ch | 2016 |
Elevated uric acid and obesity-related cardiovascular disease risk factors among hypertensive youth.
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Cross-Sectional Studies; Echocardiography; Fema | 2015 |
Association between elevated serum alanine aminotransferase and cardiometabolic risk factors in rural Chinese population: a cross-sectional study.
Topics: Adult; Age Factors; Aged; Alanine Transaminase; Blood Pressure; Body Mass Index; Cardiovascular Dise | 2015 |
Decreased urine uric acid excretion is associated with diabetic retinopathy but not with lower limb atherosclerosis in hospitalized patients with type 2 diabetes.
Topics: Aged; Alcohol Drinking; Biomarkers; China; Comorbidity; Constriction, Pathologic; Cross-Sectional St | 2015 |
A 4-year follow-up of living unrelated donors of kidney allograft in Iran.
Topics: Adult; Allografts; Anemia; Creatinine; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans | 2015 |
Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286 Japanese Workers.
Topics: Adult; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Employment; Female; Gout Suppressan | 2016 |
Association of Serum Uric Acid Level With Blood Pressure Variability in Newly Diagnosed Essential Hypertension.
Topics: Aged; Blood Pressure; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory; Circadian | 2015 |
Prevalence of hyperuricemia and its correlates in rural Northeast Chinese population: from lifestyle risk factors to metabolic comorbidities.
Topics: Adult; Aged; Aged, 80 and over; China; Comorbidity; Dyslipidemias; Female; Humans; Hypertension; Hyp | 2016 |
From the editor.
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Incidence; Male; Periodicals as Topic; Societie | 2015 |
The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia.
Topics: Adult; Allantoin; Arterial Pressure; Case-Control Studies; Female; Humans; Hypertension; Nitrites; P | 2016 |
Hyperuricemia is independently associated with left ventricular hypertrophy in post-menopausal women but not in pre-menopausal women in rural Northeast China.
Topics: Adult; Age Factors; Aged; Body Mass Index; China; Diabetes Mellitus; Dyslipidemias; Female; Humans; | 2015 |
Could Uric Acid Be Considered a Cardiovascular Risk Factor?
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Risk Factors; Uric Acid | 2015 |
Factors influencing the relationship between atrial fibrillation and artery stiffness in elderly Chinese patients with hypertension.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Arteries; Asian People; Atrial Fibrillation; Cross-Se | 2016 |
Comparative effect of fixed-dose combination tablets of candesartan cilexetil/amlodipine versus olmesartan medoxomil/azelnidipine on laboratory parameters in patients with hypertension: a retrospective cohort study.
Topics: Aged; Alanine Transaminase; Amlodipine; Antihypertensive Agents; Aspartate Aminotransferases; Azetid | 2016 |
[PHYSICAL EXERCISE TRAINING CAN- CELS CONSTITUTIVE NOS UNCOUPLING AND INDUCED VIOLATIONS OF CARDIAC HEMODYNAMICS IN HYPERTENSION (PART III)].
Topics: Animals; Blood Pressure; Calcium; Disease Progression; Hydroxyl Radical; Hypertension; Leukotriene C | 2015 |
Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study.
Topics: Adolescent; Child; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Longitudinal Studies; Ma | 2015 |
Evolutionary context for the association of γ-globin, serum uric acid, and hypertension in African Americans.
Topics: Adult; Biological Evolution; Black or African American; Black People; Chromosome Mapping; Female; ga | 2015 |
Effect of xanthine oxidase inhibitors on the renal clearance of uric acid and creatinine.
Topics: Creatinine; Gout Suppressants; Humans; Hypertension; Uric Acid; Xanthine Oxidase | 2016 |
Nocturnal and Circadian Rhythm of Blood Pressure Is Associated with Renal Structure Damage and Function in Patients with IgAN.
Topics: Adolescent; Adult; Aorta, Thoracic; Asian People; Blood Pressure; Blood Pressure Monitoring, Ambulat | 2016 |
Effects of Acute Stroke Serum on Non-Ischemic Cerebral and Mesenteric Vascular Function.
Topics: Acetylcholine; Aged; Animals; C-Reactive Protein; Cerebral Arteries; Dinoprost; Disease Models, Anim | 2016 |
Serum uric acid is associated with non-dipping circadian pattern in young patients (30-40 years old) with newly diagnosed essential hypertension.
Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein; Circadian Rhythm; | 2016 |
Influence of changes in serum uric acid levels on renal function in elderly patients with hypertension: a retrospective cohort study with 3.5-year follow-up.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Pressure; Cohort Studies; Female; Follow-Up Studies; Glom | 2016 |
Estimated nephron number of the remaining donor kidney: impact on living kidney donor outcomes.
Topics: Adult; Aged; Female; Glomerular Filtration Rate; Humans; Hypertension; Infant, Low Birth Weight; Kid | 2016 |
[The prevalence of hyperuricemia in Xinjiang Kazaks in Fuhaii].
Topics: Blood Pressure; Body Mass Index; Body Weight; China; Cross-Sectional Studies; Female; Humans; Hypert | 2015 |
Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.
Topics: Adolescent; Blood Pressure; Caloric Restriction; Female; Humans; Hypertension; Male; Minnesota; Obes | 2016 |
Prevalence and associating factors of atrial fibrillation in patients with hypertension: a nation-wide study.
Topics: Age Factors; Aged; Atrial Fibrillation; Biomarkers; Chi-Square Distribution; Cholesterol, LDL; Comor | 2016 |
Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients.
Topics: Adult; Aged; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension; Male; Middle Ag | 2016 |
Uric acid and cardiovascular-renal disease risk. Insights from a human model opposite to hypertension.
Topics: Adolescent; Adult; Aged; Biomarkers; Cardiovascular Diseases; Cohort Studies; Female; Humans; Hypert | 2016 |
Increased Serum Uric Acid Levels Blunt the Antihypertensive Efficacy of Lifestyle Modifications in Children at Cardiovascular Risk.
Topics: Anthropometry; Antihypertensive Agents; Biomarkers; Blood Pressure; Blood Pressure Determination; Bo | 2016 |
Serum Uric Acid in Primary Hypertension: From Innocent Bystander to Primum Movens?
Topics: Humans; Hypertension; Uric Acid | 2016 |
Hyperuricemia and Cardiovascular Disease in Patients with Hypertension.
Topics: Aged; Biomarkers; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Colombia; Cross-Sectio | 2016 |
Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia.
Topics: Adult; Aged; Blood Glucose; China; Cholesterol; Creatinine; Cross-Sectional Studies; Essential Hyper | 2016 |
Plasma uric acid concentrations and risk of ischaemic stroke in women.
Topics: Adult; Aged; Brain Ischemia; Case-Control Studies; Cohort Studies; Female; Humans; Hypertension; Mid | 2016 |
Effects of xanthine oxidase inhibitors on renal function and blood pressure in hypertensive patients with hyperuricemia.
Topics: Aged; Allopurinol; Blood Pressure; Enzyme Inhibitors; Febuxostat; Female; Glomerular Filtration Rate | 2016 |
Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study.
Topics: Asian People; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Hypertension; Incidence; K | 2016 |
Assessment of myocardial performance index in hypertensive patients with or without hyperuricaemia.
Topics: Aged; Echocardiography, Doppler; Female; Heart; Humans; Hypertension; Hyperuricemia; Male; Middle Ag | 2016 |
Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study.
Topics: Aged; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; Chi-Square Distribution; Female; H | 2016 |
[Correlation between serum free fatty acid level and estimated glomerular filtration rate in type 2 diabetic patients].
Topics: Albuminuria; Body Mass Index; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glomerular Filt | 2016 |
Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study.
Topics: Adolescent; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Child; Cross-Sectional S | 2016 |
Association between uric acid and renal function in hypertensive patients: which role for systemic vascular involvement?
Topics: Adult; Aged; Aorta; Body Mass Index; Carotid Intima-Media Thickness; Cross-Sectional Studies; Female | 2016 |
Clinicopathologic features of IgA nephropathy patients with different levels of proteinuria.
Topics: Adult; Atrophy; Biopsy; Female; Fibrosis; Glomerular Filtration Rate; Glomerulonephritis, IGA; Glome | 2016 |
Prevalence and factors associated with hyperuricaemia in newly diagnosed and untreated hypertensives in a sub-Saharan African setting.
Topics: Cameroon; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; P | 2016 |
Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients.
Topics: Cross-Sectional Studies; Female; Humans; Hypertension; Male; Metabolic Syndrome; Middle Aged; Preval | 2016 |
Distribution of Serum Uric Acid in Black Africans and Its Association With Cardiovascular Risk Factors.
Topics: Adult; Aged; Angola; Black People; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; | 2017 |
Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRβ.
Topics: Angiotensin II; Animals; Atherosclerosis; Cardiovascular Diseases; Cell Proliferation; Gene Expressi | 2017 |
Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age.
Topics: Adult; Age Factors; Blood Pressure; Body Mass Index; Humans; Hypertension; Japan; Male; Middle Aged; | 2016 |
Prevalence of Homocysteine-Related Hypertension in Patients With Chronic Kidney Disease.
Topics: Adolescent; Adult; Aged; Female; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteine | 2017 |
Combined oral contraceptive-induced hypertension is accompanied by endothelial dysfunction and upregulated intrarenal angiotensin II type 1 receptor gene expression.
Topics: Animals; Blood Pressure; Contraceptives, Oral, Combined; Disease Models, Animal; Dose-Response Relat | 2016 |
Association of hemoglobin with ankle-brachial index in general population.
Topics: Adult; Ankle Brachial Index; Blood Cell Count; Body Mass Index; Cardiovascular Diseases; Cholesterol | 2016 |
High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Cohort Studies; Female; Humans; Hypertension; | 2017 |
Serum uric acid change and modification of blood pressure and fasting plasma glucose in an overall healthy population sample: data from the Brisighella heart study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Diabetes Mel | 2017 |
Baseline and Change in Uric Acid Concentration Over Time Are Associated With Incident Hypertension in Large Korean Cohort.
Topics: Adult; Cohort Studies; Female; Humans; Hypertension; Male; Middle Aged; Republic of Korea; Uric Acid | 2017 |
The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome.
Topics: Adiposity; Adult; Albuminuria; Biomarkers; Blood Pressure; Chi-Square Distribution; Creatinine; Cros | 2016 |
Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study.
Topics: Adult; Arterial Pressure; Belgium; Blood Pressure; Czech Republic; Diastole; Female; Follow-Up Studi | 2016 |
Uric acid and essential hypertension: the endothelial connection.
Topics: Essential Hypertension; Humans; Hypertension; Hyperuricemia; Uric Acid | 2016 |
Correlation of the leucocyte count with traditional and non-traditional components of metabolic syndrome.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; China; Female; Fibrinogen; Humans; Hy | 2016 |
Pleiotropic protective effects of Vitamin D against high fat diet-induced metabolic syndrome in rats: One for all.
Topics: Animals; Biomarkers; Body Weight; Calcium; Cytoprotection; Diet, High-Fat; Drug Interactions; Hypert | 2016 |
Hyperuricemia is an independent risk factor for
renal pathological damage and poor prognosis in
lupus nephritis patients.
Topics: Blood Urea Nitrogen; Creatinine; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertens | 2016 |
Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males.
Topics: Adult; Aged; Asian People; China; Comorbidity; Diabetes Mellitus; Humans; Hyperlipidemias; Hypertens | 2016 |
The association of uric acid with leukoaraiosis.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Asian People; Cognitive Dysfunction; Cross-Sectional Stud | 2017 |
Association Between Hyperuricemia and Major Adverse Cardiac Events in Patients with Acute Myocardial Infarction.
Topics: Adult; Aged; Cardiovascular Diseases; Diabetes Complications; Female; Heart Failure; Humans; Hyperte | 2017 |
Is it Time to Find a Role for Uric Acid Levels in the Prevention and Management of Hypertension.
Topics: Cohort Studies; Humans; Hypertension; Hyperuricemia; Uric Acid | 2017 |
Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy.
Topics: Aged; Biomarkers; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Neuropa | 2016 |
Analysis of metabolism-related indicators and MTHFR gene polymorphism in patients with H-type hypertension.
Topics: Adult; Aged; Alleles; Blood Glucose; Creatinine; Female; Gene Frequency; Genotype; Homocysteine; Hom | 2017 |
Serum uric acid and its association with hypertension, early nephropathy and chronic kidney disease in type 2 diabetic patients.
Topics: Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Female | 2016 |
Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Sectiona | 2017 |
The burden of major adverse cardiac events in patients with coronary artery disease.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Area Under Curve; Chi-Square Distribution; | 2017 |
Associations of risk factors in childhood with arterial stiffness 26 years later: the Hanzhong adolescent hypertension cohort.
Topics: Adolescent; Adult; Blood Glucose; Blood Pressure; Child; China; Cohort Studies; Fasting; Female; Fol | 2017 |
Uric acid may be protective against cognitive impairment in older adults, but only in those without cardiovascular risk factors.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Female; Heart Failure; Humans; Hypertensio | 2017 |
Assessment of subclinical left ventricular changes in essential hypertensive patients with hyperuricemia: A three-dimensional speckle-tracking echocardiography study.
Topics: Aged; Echocardiography; Echocardiography, Three-Dimensional; Essential Hypertension; Female; Heart V | 2017 |
Uric Acid and New Onset Left Ventricular Hypertrophy: Findings From the PAMELA Population.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Echocardiograph | 2017 |
Uric Acid and Left Ventricular Hypertrophy: A Potentially New Modifiable Target?
Topics: Humans; Hypertension; Hypertrophy, Left Ventricular; Sex Factors; Uric Acid | 2017 |
Association of hematocrit with blood pressure and hypertension.
Topics: Adult; Biomarkers; Blood Pressure; Body Mass Index; Cholesterol; Female; Hematocrit; Humans; Hyperte | 2017 |
Regular physical activity prevents development of hypertension in young people with hyperuricemia.
Topics: Adult; Exercise; Female; Heart Rate; Humans; Hypertension; Hyperuricemia; Male; Proportional Hazards | 2017 |
Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Pressure; China; Female; Follow-Up Stu | 2017 |
Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan.
Topics: Adult; Anthropometry; Body Mass Index; Child; Coronary Disease; Female; Humans; Hypertension; Japan; | 2017 |
Positive association between metabolic syndrome and serum uric acid in Wuhan.
Topics: Adult; Age Factors; Body Mass Index; China; Cholesterol, LDL; Cross-Sectional Studies; Female; Human | 2017 |
Association between blood pressure and magnesium and uric acid levels in indigenous Argentinean children at high altitude.
Topics: Adolescent; Altitude; Argentina; Blood Pressure; Child; Cross-Sectional Studies; Female; Humans; Hyp | 2017 |
Serum uric acid is not independently associated with plasma renin activity and plasma aldosterone in hypertensive adults.
Topics: Adiposity; Adult; Age Factors; Aldosterone; Biomarkers; Blood Pressure; Chi-Square Distribution; Cro | 2017 |
Does the serum uric acid level have any relation to arterial stiffness or blood pressure in adults with congenital renal agenesis and/or hypoplasia?
Topics: Adult; Blood Pressure; Blood Pressure Determination; Cardiovascular Diseases; Congenital Abnormaliti | 2017 |
Inflammatory status and uricaemia determine HDL-cholesterol levels in hypertensive adults over 65: an analysis of the FAPRES register.
Topics: Aged; Biomarkers; Chi-Square Distribution; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studi | 2017 |
Serum uric acid and ambulatory blood pressure in children with primary hypertension.
Topics: Adolescent; Asian; Black or African American; Blood Pressure; Blood Pressure Monitoring, Ambulatory; | 2008 |
Does an apple a day put hypertension in play?
Topics: Amino Acid Transport Systems; Animals; Chlorides; Female; Fructose; Glucose Transport Proteins, Faci | 2008 |
Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients.
Topics: Administration, Oral; Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compou | 2008 |
Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor.
Topics: Allopurinol; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomyopathies; Dis | 2008 |
Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians.
Topics: Age Factors; Aged; Aged, 80 and over; Asian People; China; Cohort Studies; Cross-Sectional Studies; | 2009 |
Uric acid and hypertension: an age-related relationship?
Topics: Age Factors; Humans; Hypertension; Hyperuricemia; Uric Acid | 2009 |
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensins; Animals; Cells, Cultured; Disease Models | 2008 |
Hyperuricemia and its related factors in an urban population, Izmir, Turkey.
Topics: Adult; Blood Glucose; Body Composition; Creatinine; Diabetes Mellitus; Female; Gout; Humans; Hyperte | 2009 |
Association of metabolic syndrome and blood pressure nondipping profile in untreated hypertension.
Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Creatine; Cross-Sect | 2009 |
Fructose and vitamin C intake do not influence risk for developing hypertension.
Topics: Adult; Alcohol Drinking; Ascorbic Acid; Beverages; Body Mass Index; Coffee; Cohort Studies; Energy I | 2009 |
Allopurinol and the role of uric acid in hypertension.
Topics: Adolescent; Allopurinol; Drug Eruptions; Enzyme Inhibitors; Humans; Hypertension; Stevens-Johnson Sy | 2009 |
Uric acid and insulin sensitivity and risk of incident hypertension.
Topics: Adult; Biomarkers; Case-Control Studies; Endothelium, Vascular; Female; Homocysteine; Humans; Hypert | 2009 |
Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients.
Topics: Adult; Aged; Albuminuria; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Metabolic Syn | 2009 |
Use of waist circumference and ultrasonographic assessment of abdominal fat distribution in predicting metabolic risk factors in healthy Japanese adults.
Topics: Abdominal Fat; Adult; Aged; Asian People; Blood Glucose; Female; Humans; Hypertension; Lipids; Male; | 2009 |
The association between fetal and postnatal growth status and serum levels of uric acid in children at 3 years of age.
Topics: Child, Preschool; Cohort Studies; Female; Humans; Hypertension; Infant, Low Birth Weight; Infant, Ne | 2009 |
[The pleiotropic effects of losartan--the importance of decreasing uric acid level].
Topics: Antihypertensive Agents; Humans; Hypertension; Losartan; Uric Acid; Uricosuric Agents | 2008 |
Genome-wide linkage analysis for uric acid in families enriched for hypertension.
Topics: Chromosome Mapping; Chromosomes, Human, Pair 8; Cohort Studies; Creatinine; Female; Genetic Linkage; | 2009 |
Statins and hypertension.
Topics: Cardiovascular Diseases; Cholesterol; Cholesterol, LDL; Creatinine; Female; Glomerular Filtration Ra | 2009 |
Do patients with uric acid stones exhibit abnormal circadian blood pressure--a hypothesis.
Topics: Blood Pressure; Body Mass Index; Circadian Rhythm; Humans; Hypertension; Insulin Resistance; Kidney | 2009 |
Prenatal programming: maybe not so hopeless after all?
Topics: Child, Preschool; Female; Fetal Growth Retardation; Humans; Hypertension; Infant, Low Birth Weight; | 2009 |
Uric acid and the developmental origins of hypertension.
Topics: Child, Preschool; Humans; Hypertension; Infant, Low Birth Weight; Infant, Newborn; Uric Acid | 2009 |
Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET).
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Anthropometry; Blood Glucose; Cholesterol, HDL; Comorbidi | 2009 |
Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents.
Topics: Adolescent; Beverages; Black or African American; Blood Pressure; Body Mass Index; Child; Diet; Ener | 2009 |
Patients with nephrolithiasis and blood hypertension have higher calciuria than those with isolated nephrolithiasis or hypertension?
Topics: Adolescent; Adult; Algorithms; Calcium; Case-Control Studies; Humans; Hypertension; Insulin Resistan | 2009 |
How could sugar-sweetened beverages cause blood pressure elevation?
Topics: Adolescent; Beverages; Blood Pressure; Child; Dietary Sucrose; Humans; Hypertension; Sweetening Agen | 2009 |
Sour notes on sweet drinks.
Topics: Adolescent; Beverages; Blood Pressure; Child; Fructose; Humans; Hypertension; Risk Reduction Behavio | 2009 |
Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients.
Topics: Adult; Aged; Female; Humans; Hypertension; Hyperuricemia; Kidney; Kidney Failure, Chronic; Male; Mid | 2009 |
Serum uric acid and prehypertension among Chinese adults.
Topics: Adiposity; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Asian People; Blood Glucose; China; Fe | 2009 |
Uric acid as a marker for renal dysfunction in hypertensive women on diuretic and nondiuretic therapy.
Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chronic Disease; Creatinine; Cross-Se | 2009 |
Role of uric acid in post-renal transplantation hypertension.
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Kidney Transplantation; Male; Mi | 2009 |
Effect of switching from amlodipine to combination therapy with telmisartan and low-dose hydrochlorothiazide.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; | 2009 |
Optimal dietary strategies for reducing incident hypertension.
Topics: Acidosis; Blood Pressure; Dietary Proteins; Humans; Hypertension; Incidence; Potassium; Sodium; Sodi | 2009 |
Uric acid is an independent predictor of arterial stiffness in hypertensive patients.
Topics: Adult; Biomarkers; Blood Pressure; C-Reactive Protein; Carotid Arteries; Cross-Sectional Studies; El | 2009 |
Relationship between plasma uridine and urinary urea excretion.
Topics: Adult; Creatinine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Gout; Homeostasis; H | 2010 |
Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension.
Topics: Adolescent; Adult; Aged; Asian People; Blood Glucose; Case-Control Studies; China; Cholesterol; Cros | 2009 |
Hyperuricemia, cardiovascular disease, and the metabolic syndrome.
Topics: Angiotensin II; Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Metabolic Syndrome; Ob | 2009 |
Incidence of Type 2 diabetes in the elderly German population and the effect of clinical and lifestyle risk factors: KORA S4/F4 cohort study.
Topics: Aged; Blood Glucose; Blood Pressure; Cohort Studies; Diabetes Mellitus, Type 2; Female; Germany; Glu | 2009 |
Diabetic retinopathy is associated with visceral fat accumulation in Japanese type 2 diabetes mellitus patients.
Topics: Adiposity; Aged; Anthropometry; Blood Glucose; Blood Pressure; Body Composition; Body Mass Index; Di | 2010 |
Serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population.
Topics: Adult; Aged; Cardiovascular Diseases; China; Cross-Sectional Studies; Dyslipidemias; Ethnicity; Fema | 2009 |
A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients.
Topics: Aged; Biomarkers; Creatinine; Diuretics; Female; Follow-Up Studies; Humans; Hypertension; Hyperurice | 2011 |
Association of serum uric acid with aortic stiffness and pressure in a Chinese workplace setting.
Topics: Adolescent; Adult; Aged; Aorta; Blood Pressure; Carotid Arteries; China; Cross-Sectional Studies; Fe | 2010 |
The prevalence of microalbuminuria and its relationships with the components of metabolic syndrome in the general population of China.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Albuminuria; Blood Glucose; Blood Pressure; | 2010 |
[Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population].
Topics: Adult; Aged; Asian People; Blood Pressure; Case-Control Studies; China; Female; Genetic Predispositi | 2010 |
Uric acid and the cardiovascular profile of African and Caucasian men.
Topics: Adult; Biomarkers; Black People; Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; H | 2010 |
High inflammatory activity related to the number of metabolic syndrome components.
Topics: Blood Cell Count; Body Mass Index; C-Reactive Protein; Case-Control Studies; Female; Fibrinogen; Hum | 2010 |
Diabese youngsters have 3.7 more chances in developing metabolic syndrome compared with the obese.
Topics: Adolescent; Child; Child, Preschool; Diabetes Complications; Female; Humans; Hypertension; Male; Met | 2010 |
Effects of additional administration of low-dose indapamide on patients with hypertension treated with angiotensin II receptor blocker.
Topics: Age Factors; Aged; Angiotensin II Type 2 Receptor Blockers; Antihypertensive Agents; Blood Pressure; | 2010 |
Serum uric acid levels and renal damage in hyperuricemic hypertensive patients treated with renin-angiotensin system blockers.
Topics: Adult; Aged; Allopurinol; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inh | 2010 |
Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Blotting, Western; Desoxycorticosterone; Endo | 2010 |
Factors associated with persistent hypertension after puerperium among women with pre-eclampsia/eclampsia in Mulago hospital, Uganda.
Topics: Adolescent; Adult; Case-Control Studies; Chronic Disease; Creatinine; Eclampsia; Female; Humans; Hyp | 2010 |
Association between capacity of interferon-alpha production and metabolic parameters.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Disease Susceptibility; Female; Humans; Hyperglycemia; | 2010 |
The serum uric acid concentration in essential hypertension.
Topics: Essential Hypertension; Humans; Hypertension; Uric Acid | 1947 |
Very low-grade albuminuria reflects susceptibility to chronic kidney disease in combination with cardiovascular risk factors.
Topics: Adult; Albuminuria; Cardiovascular Diseases; Chronic Disease; Cohort Studies; Creatinine; Cross-Sect | 2010 |
High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension.
Topics: Adolescent; Blood Platelets; Blood Pressure; C-Reactive Protein; Child; Erythrocytes; Female; Humans | 2010 |
Effect of uric acid on hypertension progression in spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Blood Pressure; Cell Movement; Cytokines; Disease Progression; Gene Expressio | 2010 |
Association of serum uric acid level with aortic stiffness and arterial wave reflections in newly diagnosed, never-treated hypertension.
Topics: Aorta; Blood Flow Velocity; Carotid Arteries; Elasticity; Female; Humans; Hypertension; Linear Model | 2011 |
Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students.
Topics: Adolescent; Asian People; Dyslipidemias; Female; Heart Diseases; Humans; Hypertension; Male; Metabol | 2010 |
Prevalence and risk factors for renal artery stenosis and chronic kidney disease in Japanese patients with peripheral arterial disease.
Topics: Age Factors; Aged; Aged, 80 and over; Albuminuria; Angiography; Asian People; Cholesterol, LDL; Como | 2010 |
Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins.
Topics: Adult; Biomarkers; Blood Pressure; California; Cross-Sectional Studies; Dyslipidemias; Fatty Liver; | 2010 |
Association of uric acid with risk factors for chronic kidney disease and metabolic syndrome in patients with essential hypertension.
Topics: Adult; Age Factors; Aged; Biomarkers; Blood Glucose; Blood Pressure; Chronic Disease; Creatinine; Fe | 2010 |
Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome.
Topics: Aged; Aortic Diseases; Blood Pressure; Cardiovascular Diseases; Dilatation, Pathologic; Echocardiogr | 2010 |
Uric acid potentially links fatty liver and high blood pressure.
Topics: Fatty Liver; Humans; Hypertension; Hyperuricemia; Logistic Models; Uric Acid | 2010 |
The serum urate-lowering impact of weight loss among men with a high cardiovascular risk profile: the Multiple Risk Factor Intervention Trial.
Topics: Body Weight; Cardiovascular Diseases; Cohort Studies; Follow-Up Studies; Gout; Humans; Hypertension; | 2010 |
Dietary intake and the risk of hyperuricemia, gout and chronic kidney disease in elderly Taiwanese men.
Topics: Aged; Antihypertensive Agents; Chronic Disease; Comorbidity; Diet; Feeding Behavior; Glomerular Filt | 2011 |
Managing hypertensive patients with gout who take thiazide.
Topics: Adult; Aged; Diuretics; Female; Gout; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; | 2010 |
Serum uric acid levels and the risk of type 2 diabetes: a prospective study.
Topics: Adult; Age Factors; Alcohol Drinking; Blood Glucose; Body Mass Index; Cholesterol; Creatinine; Diabe | 2010 |
Serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the MAGIC study.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middle Aged; Prospective Studi | 2011 |
The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives.
Topics: Adiponectin; Adult; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Hypertension; Infla | 2011 |
Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure.
Topics: Adipokines; Aged; Biomarkers; Case-Control Studies; Chitinase-3-Like Protein 1; Creatinine; Enzyme-L | 2010 |
Just a spoonful of sugar helps the blood pressure go up.
Topics: Animals; Blood Glucose; Blood Pressure; Fructose; Humans; Hypertension; Metabolic Syndrome; Risk Fac | 2010 |
Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan.
Topics: Aged; Antihypertensive Agents; Cohort Studies; Female; Glomerular Filtration Rate; Humans; Hypertens | 2012 |
Uric acid and cardiovascular risk in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cardiovascular Diseases; Disease Models, Animal; Humans; Hypertensio | 2011 |
Geographic and demographic variability in 20-year hypertension incidence: the CARDIA study.
Topics: Adolescent; Adult; Age Factors; Alcohol Drinking; Antihypertensive Agents; Black People; Body Mass I | 2011 |
Interaction between serum uric acid and triglycerides in relation to blood pressure.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Blood Glucose; Blood Pressure; Bod | 2011 |
Uric acid levels, left ventricular mass and geometry in newly diagnosed, never treated hypertension.
Topics: Blood Flow Velocity; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; | 2011 |
High levels of uric acid correlate with decline of glomerular filtration rate in chronic kidney disease.
Topics: Adult; Aged; Biomarkers; Blood Pressure; Body Mass Index; Chronic Disease; Cross-Sectional Studies; | 2010 |
A genome-wide association study of serum uric acid in African Americans.
Topics: Black or African American; Black People; Body Mass Index; Diabetes Mellitus, Type 2; Genome-Wide Ass | 2011 |
Metabolic syndrome does not impose greater atrial fibrillation risk in elderly hypertensive patients.
Topics: Age Factors; Aged; Atrial Fibrillation; Creatinine; Diuretics; Female; Humans; Hypertension; Hypertr | 2010 |
Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis.
Topics: Adult; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Cholesterol; Heart | 2011 |
[Endothelial function in patients with arterial hypertension and impaired uric acid metabolism].
Topics: Adult; Albuminuria; Antihypertensive Agents; Endothelin-1; Endothelium, Vascular; Female; Humans; Hy | 2010 |
[Hyperuricemia].
Topics: Biomarkers; Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Uric Acid | 2011 |
Serum uric acid is associated with high blood pressure in pediatric hemodialysis patients.
Topics: Adolescent; Antihypertensive Agents; Biomarkers; Blood Pressure; Body Weight; Child; Female; Humans; | 2011 |
Uric acid levels and atrial fibrillation in hypertensive patients.
Topics: Adult; Aged; Atrial Fibrillation; Biomarkers; Creatinine; Cross-Sectional Studies; Echocardiography; | 2011 |
Gout.
Topics: Allopurinol; Antihypertensive Agents; Gout; Gout Suppressants; Humans; Hydrochlorothiazide; Hyperten | 2011 |
Adverse effect profile of trichlormethiazide: a retrospective observational study.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Biomarkers; Blood Urea Nitrogen; Chi-Square Distri | 2011 |
Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease.
Topics: Aged; Analysis of Variance; Blood Pressure Determination; Cohort Studies; Diet, Carbohydrate-Restric | 2012 |
Effect of vitamin E therapy on serum uric acid in DOCA-salt-treated rats.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Hypertension; Injections, Sub | 2011 |
Oxidative stress and endothelin-1 in atherosclerotic renal artery stenosis and effects of renal angioplasty.
Topics: Aged; Angioplasty; Atherosclerosis; Biomarkers; Endothelin-1; Female; Humans; Hypertension; Male; Mi | 2011 |
Gender-specific risk factors for incident gout: a prospective cohort study.
Topics: Adult; Comorbidity; Female; Follow-Up Studies; Gout; Humans; Hyperlipidemias; Hypertension; Incidenc | 2012 |
Effect of A-HRS on blood pressure and metabolic alterations in fructose-induced hypertensive rats.
Topics: Animals; Blood Glucose; Blood Pressure; Cholesterol; Drug Evaluation, Preclinical; Fructose; Hibiscu | 2012 |
Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis.
Topics: Aged; Blood Pressure; Diabetes Mellitus; Humans; Hydrogen-Ion Concentration; Hypertension; Insulin R | 2012 |
Risk profile in chronic kidney disease stage 3: older versus younger patients.
Topics: Age Factors; Aged; Aged, 80 and over; Albuminuria; Atherosclerosis; Cardiovascular Diseases; Diabeti | 2011 |
Impact of different adiposity measures on the relation between serum uric acid and blood pressure in young adults.
Topics: Adiposity; Blood Pressure; Body Mass Index; Cohort Studies; Electric Impedance; Female; Humans; Hype | 2012 |
Relationship of dyslipidemia and uric acid with the risk of myocardial infarction among hypertensive patients in Trinidad.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Dyslipidemias; Fema | 2011 |
Beneficial effect of switching from a combination of angiotensin II receptor blockers other than losartan and thiazides to a fixed dose of losartan/hydrochlorothiazide on uric acid metabolism in hypertensive patients.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Dose-Respons | 2011 |
Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals.
Topics: Autonomic Nervous System; Blood Pressure; C-Reactive Protein; Circadian Rhythm; Cross-Sectional Stud | 2011 |
Serum uric acid and 1-h postload glucose in essential hypertension.
Topics: Adult; Blood Glucose; Cohort Studies; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glucos | 2012 |
Risk factors for postpartum hypertension in women with twin pregnancies.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Blood Urea Nitrogen; Creatinine; Diastole; | 2011 |
Diuretic use, increased serum urate levels, and risk of incident gout in a population-based study of adults with hypertension: the Atherosclerosis Risk in Communities cohort study.
Topics: Community Medicine; Comorbidity; Diuretics; Female; Gout; Humans; Hypertension; Male; Middle Aged; P | 2012 |
Uric acid and blood pressure.
Topics: Blood Pressure; Humans; Hypertension; Male; Uric Acid | 2011 |
Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the reduction of end points in noninsulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial.
Topics: Angiotensin II Type 1 Receptor Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; | 2012 |
Antihypertensive effect of a fixed-dose combination of losartan/hydrochlorothiazide in patients with uncontrolled hypertension: a multicenter study.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Creatinine; Drug | 2012 |
Relationship between hyperuricemia and chronic kidney disease.
Topics: Glomerulonephritis, IGA; Humans; Hypertension; Hyperuricemia; Kidney; Kidney Failure, Chronic; Kidne | 2011 |
Gender distribution of serum uric acid and cardiovascular risk factors: population based study.
Topics: Adult; Biomarkers; Body Mass Index; Brazil; Epidemiologic Methods; Female; Humans; Hypertension; Hyp | 2012 |
Plasma renin activity (PRA) levels and antihypertensive drug use in a large healthcare system.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin Receptor Antagonists; Angiotensin- | 2012 |
Genotype-based changes in serum uric acid affect blood pressure.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Amish; Blood Pressure; Diet, Sodium-Restricted; Female; Gen | 2012 |
External validation of the KORA S4/F4 prediction models for the risk of developing type 2 diabetes in older adults: the PREVEND study.
Topics: Adult; Age Factors; Aged; Biomarkers; Blood Glucose; Body Mass Index; Decision Support Techniques; D | 2012 |
Unknown: Multiple painful nodules - what is the diagnosis? Chronic tophaceous gout.
Topics: Alcoholics; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Chronic Disease; Colch | 2011 |
Interaction between uric acid and endothelial dysfunction predicts new onset of diabetes in hypertensive patients.
Topics: Adult; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hyperten | 2013 |
Uric acid, hypertension, and chronic kidney disease among Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.
Topics: Adult; Alaska; Coronary Artery Disease; Female; Glomerular Filtration Rate; Humans; Hypertension; In | 2012 |
Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cohort Studies; Confounding Factors, Epidemiologic; Cros | 2012 |
Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999-2006.
Topics: Adolescent; Biomarkers; Blood Pressure; Cardiovascular Diseases; Child; Cohort Studies; Cross-Sectio | 2012 |
Predictors of the development of metabolic syndrome in male workers: a 3-year follow-up study.
Topics: Adult; Age Factors; Alcohol Drinking; Cholesterol, HDL; Confidence Intervals; Exercise; Follow-Up St | 2012 |
Calciuria and preeclampsia: a case-control study.
Topics: Adult; Calcium; Case-Control Studies; Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; ROC Cu | 2012 |
Uric acid is an important predictor for hypertensive early atherosclerosis.
Topics: Adult; Atherosclerosis; Biomarkers; C-Reactive Protein; Carotid Arteries; Carotid Intima-Media Thick | 2012 |
Association between gout and polymorphisms in GCKR in male Han Chinese.
Topics: Adaptor Proteins, Signal Transducing; Asian People; Blood Glucose; Case-Control Studies; China; Chol | 2012 |
Individuals with high-normal blood pressure have different metabolic and haemodynamic characteristics to those with optimal blood pressure.
Topics: Adult; Baroreflex; Blood Glucose; Blood Pressure; Blood Pressure Determination; Carotid Intima-Media | 2012 |
[ High normal blood pressure - a problem of growing clinical importance].
Topics: Baroreflex; Blood Glucose; Blood Pressure; Female; Humans; Hypertension; Male; Uric Acid | 2012 |
Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men.
Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Creatinine; Cross-Sec | 2013 |
[Uric acid, atherosclerosis and vascular calcifications in chronic kidney disease].
Topics: Adolescent; Adult; Aged; Atherosclerosis; Calcinosis; Cardiovascular Diseases; Chronic Disease; Como | 2012 |
Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Cardiovascul | 2012 |
Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: a Chinese cohort study.
Topics: Adult; Asian People; Biomarkers; Blood Pressure; Cohort Studies; Disease Progression; Female; Humans | 2012 |
Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension.
Topics: Aged; Aged, 80 and over; Amlodipine; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hyp | 2012 |
Association between sodium intake and change in uric acid, urine albumin excretion, and the risk of developing hypertension.
Topics: Adult; Albuminuria; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Humans; Hypertension; Lon | 2012 |
Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients.
Topics: Biomarkers; Cardiovascular Diseases; Cohort Studies; Essential Hypertension; Female; Follow-Up Studi | 2012 |
A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study.
Topics: Databases, Factual; Diuretics; Drug Interactions; Female; Genotype; Glucose Transport Proteins, Faci | 2013 |
The effects of phentolamine on fructose-fed rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Glucose; Blood Pressure; Disease Models | 2012 |
Do genotype-based changes in serum uric acid really affect blood pressure?
Topics: Blood Pressure; Female; Genotype; Glucose Transport Proteins, Facilitative; Humans; Hypertension; Ma | 2012 |
Metabolic syndrome and urinary stone composition: what factors matter most?
Topics: Adult; Aged; Calcium Oxalate; Calcium Phosphates; Diabetes Complications; Dyslipidemias; Female; Hum | 2012 |
Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study.
Topics: Biomarkers; Carotid Artery, Internal; Carotid Intima-Media Thickness; Chi-Square Distribution; Compl | 2012 |
Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cause of Death; Female; Heart Failure; Huma | 2013 |
The relationship between serum uric acid concentration and metabolic syndrome in patients with schizophrenia or schizoaffective disorder.
Topics: Adult; Cholesterol, HDL; Cross-Sectional Studies; Female; Humans; Hypertension; Hypertriglyceridemia | 2012 |
[The hyperuricosuria in patients with high content of triglycerides: the combination of genetic and environmental factors and tactics of treatment].
Topics: Adolescent; Adult; Aged; Environment; Fructose; Humans; Hypertension; Hypertriglyceridemia; Lipoprot | 2012 |
Effect of hyperuricemia on the blood pressure response to antihypertensive agents in hospitalized elderly patients.
Topics: Aged; Antihypertensive Agents; Biomarkers; Blood Pressure; Chi-Square Distribution; Diabetes Mellitu | 2012 |
Dietary fructose in relation to blood pressure and serum uric acid in adolescent boys and girls.
Topics: Adolescent; Age Factors; Arterial Pressure; Chi-Square Distribution; Cross-Sectional Studies; Dietar | 2013 |
Serum urate association with hypertension in young adults: analysis from the Coronary Artery Risk Development in Young Adults cohort.
Topics: Cohort Studies; Comorbidity; Female; Humans; Hypertension; Hyperuricemia; Male; Retrospective Studie | 2013 |
High-salt diet may cause hypertension. Study suggests excessive salt use may damage blood vessels.
Topics: Biomarkers; Diet, Sodium-Restricted; Humans; Hypertension; Serum Albumin; Sodium Chloride, Dietary; | 2012 |
Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambuì Cohort Study of Ageing (1997-2008).
Topics: Aged; Aged, 80 and over; Aging; Alleles; Apolipoproteins E; Blood Pressure; Brazil; Cohort Studies; | 2013 |
Hyperuricemia and hypertension.
Topics: Adolescent; Animals; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Rats; Risk Factors | 2012 |
Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk.
Topics: Adolescent; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Child; Choleste | 2013 |
Serum uric acid, kidney volume and progression in autosomal-dominant polycystic kidney disease.
Topics: Adult; Cohort Studies; Disease Progression; Female; Humans; Hypertension; Hyperuricemia; Kidney; Kid | 2013 |
Uric acid: where are we?
Topics: Animals; Biomarkers; Cardiovascular Diseases; Causality; Circadian Rhythm; Humans; Hypertension; Rat | 2013 |
Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension.
Topics: Analysis of Variance; Biomarkers; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein; Case-Co | 2013 |
Comparison of demographic, clinical, and laboratory parameters between patients with sustained normotension, white coat hypertension, masked hypertension, and sustained hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Female; Humans; H | 2013 |
Serum uric acid is associated with dietary and lifestyle factors in elderly women in suburban Guangzhou in Guangdong province of south China.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Animals; Anthropometry; China; Cholesterol, HDL; Choleste | 2013 |
Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals.
Topics: Black or African American; Demography; Female; Fructokinases; Genetic Predisposition to Disease; Glu | 2013 |
Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke.
Topics: Aged; Cerebral Hemorrhage; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; Stroke; Ur | 2013 |
Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Pressure; Body Weight; Caloric Restriction; Chroma | 2002 |
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity.
Topics: Animals; Blood Pressure; Cardiovascular Diseases; Cell Division; Cells, Cultured; Developed Countrie | 2002 |
The metabolic syndrome in black hypertensive women--waist circumference more strongly related than body mass index.
Topics: Black People; Blood Glucose; Body Constitution; Body Mass Index; Cholesterol, HDL; Cross-Sectional S | 2002 |
[Glucose effectiveness and components of the metabolic syndrome in recently diagnosed hypertensive patients].
Topics: Adult; Aged; Cholesterol, VLDL; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glucose; | 2002 |
A role for uric acid in the progression of renal disease.
Topics: Animals; Blood Pressure; Cell Division; Cyclooxygenase 2; Disease Progression; Hypertension; Hypertr | 2002 |
A role for uric acid in the progression of renal disease.
Topics: Animals; Blood Pressure; Cell Division; Cyclooxygenase 2; Disease Progression; Hypertension; Hypertr | 2002 |
A role for uric acid in the progression of renal disease.
Topics: Animals; Blood Pressure; Cell Division; Cyclooxygenase 2; Disease Progression; Hypertension; Hypertr | 2002 |
A role for uric acid in the progression of renal disease.
Topics: Animals; Blood Pressure; Cell Division; Cyclooxygenase 2; Disease Progression; Hypertension; Hypertr | 2002 |
[Drug-induced hypouricemia: pathophysiology and application to the hyperuricemia with life style related disease].
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Infective Agents; Fanconi Syndrome; Humans; Hyperlipi | 2003 |
Tubular injury: the first symptom of hypertensive kidney involvement?
Topics: Acetylglucosaminidase; Adolescent; Adult; Albuminuria; Biomarkers; Female; Fructose; Glucose Toleran | 2003 |
Nephrolithiasis in Cushing's disease: prevalence, etiopathogenesis, and modification after disease cure.
Topics: Adult; Analysis of Variance; Body Mass Index; Calcium; Citric Acid; Cushing Syndrome; Cystine; Cysti | 2003 |
Serum uric acid in hypertensive patients with and without peripheral arterial disease.
Topics: Aged; Belgium; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; C-Reactive Protein; Chole | 2003 |
The ALLHAT and the cardioprotection conferred by diuretics in hypertensive patients: a connection with uric acid?
Topics: Antihypertensive Agents; Cardiotonic Agents; Diuretics; Humans; Hypertension; Hypolipidemic Agents; | 2002 |
Editorial comment--Elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective.
Topics: Animals; Antioxidants; Brain Ischemia; Causality; Humans; Hypertension; Hyperuricemia; Neuroprotecti | 2003 |
A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide.
Topics: Acute Kidney Injury; Antihypertensive Agents; Benzbromarone; Blood Cell Count; Creatinine; Diuretics | 2003 |
Hyperuricemia in childhood primary hypertension.
Topics: Adolescent; Analysis of Variance; Blood Pressure; Body Mass Index; Child; Diastole; Female; Glomerul | 2003 |
Leptin might be a regulator of serum uric acid concentrations in humans.
Topics: Adult; Body Mass Index; Cholesterol; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperuri | 2003 |
Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers.
Topics: Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Fasting; Humans; Hypertension; Inc | 2003 |
Comparison of different risk factors that result in endothelial damage leading to diabetic microangiopathy.
Topics: Adult; Antigens; Diabetes Complications; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyper | 2003 |
[Arterial hypertension, its metabolic aspects and kidney function in patients after hemorrhagic fever with renal syndrome].
Topics: Adolescent; Adult; Blood Pressure; Cholesterol; Female; Hemorrhagic Fever with Renal Syndrome; Human | 2003 |
The increase in serum uric acid induced by diuretics could be beneficial to cardiovascular prognosis in hypertension: a hypothesis.
Topics: Diuretics; Humans; Hypertension; Prognosis; Uric Acid | 2003 |
Effect of cilazapril with or without low dose thiazide on LDL peroxidation in [correction of peroxidationin] hypertensive patients.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area Under Curve; Biomarkers; Blo | 2003 |
Prevalence of obesity in an elderly Hungarian population.
Topics: Age Distribution; Aged; Aged, 80 and over; Blood Glucose; Body Mass Index; Case-Control Studies; Com | 2003 |
Hyperuricaemia related to treatment of hypertension.
Topics: Antihypertensive Agents; Humans; Hypertension; Hyperuricemia; Uric Acid | 1960 |
Hyperuricemia induced by the administration of chlorthalidone and other sulfonamide diuretics.
Topics: Chlorthalidone; Diuretics; Humans; Hypertension; Hyperuricemia; Sulfanilamide; Sulfanilamides; Sulfo | 1962 |
Serum uric acid levels in hypertensive patients treated with guanethidine.
Topics: Amidines; Guanethidine; Humans; Hypertension; Uric Acid | 1962 |
Treatment of arterial hypertensive disease with diuretics. II. Effects on electrolytes and uric acid of bendroflumethiazide, potassium chloride, and spironolactone.
Topics: Bendroflumethiazide; Diuretics; Electrolytes; Humans; Hypertension; Potassium Chloride; Spironolacto | 1962 |
Gout and hyperuricemia after adrenalectomy for hypertension.
Topics: Adrenalectomy; Gout; Humans; Hypertension; Hyperuricemia; Uric Acid | 1963 |
USE OF DIAZOXIDE WITH TRICHLORMETHIAZIDE FOR HYPERTENSION.
Topics: Acidosis; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Body Weight; Diazoxide; Hyperg | 1963 |
CLINICAL TRIAL OF A NEW ORAL DIURETIC, M & B 8430.
Topics: Blood Chemical Analysis; Blood Pressure; Blood Pressure Determination; Chlorides; Diuretics; Hyperte | 1964 |
[CLINICAL CONTRIBUTION TO THE STUDY OF A NEW SYNTHETIC ANTICHOLESTEREMIC AGENT: BETA-BENZALBUTYRRAMIDE].
Topics: Amides; Anticholesteremic Agents; Arthritis; Arthritis, Rheumatoid; Asthma; Butyrates; Cholelithiasi | 1963 |
[TREATMENT OF URIC LITHIASIS].
Topics: Bicarbonates; Calcium Metabolism Disorders; Citrates; Diet; Diet Therapy; Diuresis; Gout; Humans; Hy | 1963 |
GOUT, HYPERURICAEMIA AND CARBOHYDRATE METABOLISM.
Topics: Carbohydrate Metabolism; Cholesterol; Glucose Tolerance Test; Gout; Humans; Hypertension; Hyperurice | 1964 |
[THE KIDNEY IN CHRONIC LEAD POISONING].
Topics: Edetic Acid; Electrons; Gout; Humans; Hypertension; Kidney; Kidney Diseases; Kidney Function Tests; | 1964 |
CLINICAL TRIAL OF TRIAMTERENE IN HYPERTENSIVE PATIENTS.
Topics: Biomedical Research; Blood Chemical Analysis; Blood Pressure Determination; Diuretics; Gout; Hyperal | 1964 |
RENAL ARTERIOLAR DISEASE IN YOUNG PRIMIPARAS.
Topics: Adolescent; Arteries; Black People; Blood Chemical Analysis; Body Weight; Eclampsia; Female; Humans; | 1964 |
POLYTHIAZIDE AND RESERPINE COMBINED IN THE OFFICE TREATMENT OF HYPERTENSION.
Topics: Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Diuretics; Gastroenteritis; | 1964 |
A COMPARATIVE STUDY OF THE DIURETICS CHLORTHALIDONUM AND CYCLOPENTHIAZIDUM.
Topics: Benzothiadiazines; Bicarbonates; Biomedical Research; Blood; Chlorides; Chlorthalidone; Diet, Sodium | 1964 |
COMBINATION DRUG THERAPY OF ESSENTIAL HYPERTENSION.
Topics: Antihypertensive Agents; Blood; Blood Pressure; Blood Pressure Determination; Diuretics; Drug Therap | 1964 |
[DEHYDROEPIANDROSTERONE DEFICIENCY IN THE URINE PATIENTS WITH HYPERTENSION].
Topics: Chromatography; Dehydroepiandrosterone; Fundus Oculi; Humans; Hypertension; Uric Acid; Urine | 1964 |
THIAZIDE- AND PHTHALIMIDINE-INDUCED HYPERGLYCEMIA IN HYPERTENSIVE PATIENTS.
Topics: Amylases; Blood Chemical Analysis; Chlorthalidone; Creatine; Creatinine; Diabetes Mellitus; Drug The | 1965 |
BENZOTHIADIAXINES AND DIABETES MELLITUS. II. COMPARISON OF HYPERGLYCEMIC EFFECTS OF BENDROFLUMETHIAZIDE AND CHLOROTHIAZIDE IN HYPERTENSIVE PATIENTS WITH DIABETES MELLITUS.
Topics: Amylases; Bendroflumethiazide; Blood; Blood Glucose; Chlorothiazide; Diabetes Mellitus; Drug Therapy | 1964 |
USE OF BENDROFLUMETHIAZIDE WITH POTASSIUM SUPPLEMENT IN TOXEMIA OF PREGNANCY.
Topics: Bendroflumethiazide; Blood; Blood Pressure; Drug Therapy; Eclampsia; Edema; Female; Fetal Death; Hum | 1965 |
[SECONDARY GOUT IN CHRONIC NEPHROPATHIES].
Topics: Amyloidosis; Blood; Colchicine; Drug Therapy; Gout; Humans; Hypertension; Hypertension, Renal; Kidne | 1965 |
PARGYLINE HYDROCHLORIDE AND METHYCLOTHIAZIDE COMBINED IN THE TREATMENT OF HYPERTENSION.
Topics: Biomedical Research; Blood Coagulation Tests; Drug Therapy; Geriatrics; Hematocrit; Hemoglobins; Hum | 1965 |
HYPERURICAEMIA IN HYPERTENSION.
Topics: Blood; Body Weight; Cholesterol; Creatine; Creatinine; Dehydroepiandrosterone; Fluids and Secretions | 1965 |
HEMODIALYSIS FOR CHRONIC RENAL FAILURE. II. BIOCHEMICAL AND CLINICAL ASPECTS.
Topics: Anemia; Biochemical Phenomena; Biochemistry; Blood; Blood Pressure; Blood Urea Nitrogen; Calcium; Ch | 1965 |
THE TREATMENT OF HYPERTENSION WITH CHLORTHALIDONE, A LONG-ACTING DIURETIC AGENT.
Topics: Blood; Blood Glucose; Chlorthalidone; Diuretics; Drug Therapy; Humans; Hypertension; Toxicology; Uri | 1965 |
THE USE OF ALLOPURINOL (HPP) TO CONTROL HYPERURICEMIA IN PATIENTS ON CHRONIC INTERMITTENT HEMODIALYSIS.
Topics: Allopurinol; Blood; Creatine; Creatinine; Drug Therapy; Glomerulonephritis; Humans; Hypertension; Hy | 1965 |
METHODS OF MEASURING GLOMERULAR-FILTRATION RATE: A COMPARISON OF INULIN, VITAMIN-B 12 AND CREATININE CLEARANCES.
Topics: Cobalt Isotopes; Creatine; Creatinine; Diagnosis; Glomerular Filtration Rate; Gout; Humans; Hyperten | 1965 |
[OVER-EXERTION AND METABOLIC DISORDERS].
Topics: Balneology; Blood; Catalase; Fatigue; Humans; Hyperlipidemias; Hypertension; Liver; Metabolic Diseas | 1965 |
Diurnal variations in renal excretion of electrolytes, uric acid and total amino nitrogen in various renal diseases and in essential hypertension.
Topics: Electrolytes; Essential Hypertension; Humans; Hypertension; Kidney Diseases; Nitrogen; Periodicity; | 1961 |
Proportion of treatment effect (PTE) explained by a surrogate marker.
Topics: Antihypertensive Agents; Atenolol; Biomarkers; Confidence Intervals; Data Interpretation, Statistica | 2003 |
[Risk factors for eclampsia: a case-control study].
Topics: Adult; Analysis of Variance; Aspartate Aminotransferases; Case-Control Studies; Creatinine; Eclampsi | 2003 |
Clustering of components of the metabolic syndrome and risk for development of type 2 diabetes in Japanese male office workers.
Topics: Adult; Analysis of Variance; Blood Glucose; Body Mass Index; Cholesterol, LDL; Cluster Analysis; Dia | 2004 |
Hyperuricemia, low urine urate excretion and target organ damage in arterial hypertension.
Topics: Adult; Arteries; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Humans; Hypertension; H | 2003 |
Combination of renin-angiotensin system polymorphisms is associated with altered renal sodium handling and hypertension.
Topics: Adult; Aged; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Kidn | 2004 |
Selected risk factors of ischemic heart disease in Polish seafarers. Preliminary report.
Topics: Adult; Age Distribution; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Me | 2003 |
Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adrenal Cortex Hormones; Adult; Aldosterone; Bicarbonat | 2004 |
Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002.
Topics: Adolescent; Adult; Alanine Transaminase; Body Mass Index; Cholesterol; Humans; Hypertension; Hyperur | 2004 |
Family-based associations between the angiotensin- converting enzyme insertion/deletion polymorphism and multiple cardiovascular risk factors in Chinese.
Topics: Adult; Aged; Asian People; Blood Glucose; Blood Pressure; Body Mass Index; Creatinine; Family Health | 2004 |
Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia.
Topics: Adult; Arrhythmias, Cardiac; Arteriosclerosis; Female; Follow-Up Studies; Humans; Hypertension; Hype | 2004 |
Xanthine oxidase inhibition by 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), an antagonist of adenosine receptors.
Topics: Animals; Blood Pressure; Cardiovascular Diseases; Free Radical Scavengers; Hypertension; Oxidants; O | 2004 |
Clinical characteristics of young-onset hypertension-implications for different genders.
Topics: Adult; Age Factors; Alcohol Drinking; Blood Glucose; Body Mass Index; Case-Control Studies; Choleste | 2004 |
Hyperuricaemia and cardiovascular disease.
Topics: Female; Humans; Hypertension; Hyperuricemia; Male; Retrospective Studies; Uric Acid | 2004 |
Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.
Topics: Animals; Blood Urea Nitrogen; Cyclooxygenase 2; Disease Progression; Enzyme Induction; Female; Genes | 2004 |
A prediction model for superimposed preeclampsia in women with chronic hypertension during pregnancy.
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Models, Theoretical; Pre-Eclampsia; Predictive | 2004 |
Application of three-dimensional body scanner: observation of prevalence of metabolic syndrome.
Topics: Adult; Aged; Aged, 80 and over; Anthropometry; Blood Glucose; Body Composition; Body Constitution; B | 2004 |
Resurrection of uric acid as a causal risk factor in essential hypertension.
Topics: Animals; Disease Progression; Humans; Hypertension; Hyperuricemia; Predictive Value of Tests; Progno | 2005 |
Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence.
Topics: Adult; Blood Pressure; Cohort Studies; Diabetes Mellitus; Disease Progression; Female; Follow-Up Stu | 2005 |
Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study.
Topics: Adolescent; Adult; Age Factors; Black or African American; Child; Child, Preschool; Cross-Sectional | 2005 |
The pathophysiology of hyperuricemia in essential hypertension: a pilot study.
Topics: Adult; Aged; Creatinine; Glucose Tolerance Test; Humans; Hypertension; Hyperuricemia; Insulin; Insul | 2004 |
Disturbances in renal autoregulation and the susceptibility to hypertension-induced chronic kidney disease.
Topics: Aging; Animals; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Fetal Growth Retar | 2004 |
The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage.
Topics: Albuminuria; Biomarkers; Blood Pressure; Body Mass Index; Echocardiography; Female; Follow-Up Studie | 2005 |
[Arterial hypertension in adolescents with different physical constitution including those with signs of metabolic syndrome].
Topics: Adolescent; Body Mass Index; Body Weights and Measures; Child; Cholesterol; Female; Glucose Toleranc | 2004 |
Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia.
Topics: Adult; Biomarkers; Female; Humans; Hypertension; Membrane Proteins; Pre-Eclampsia; Pregnancy; Pregna | 2005 |
Observation of the serum uric acid in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Cholesterol; Creatinine; Female; Humans; Hypertens | 1986 |
Serum uric acid and target organ damage in primary hypertension.
Topics: Adult; Albuminuria; Biomarkers; Carotid Artery Diseases; Female; Humans; Hypertension; Hypertrophy, | 2005 |
Metabolic syndrome is associated with early signs of organ damage in nondiabetic, hypertensive patients.
Topics: Albuminuria; Analysis of Variance; Blood Glucose; Body Mass Index; Cardiovascular Diseases; Carotid | 2005 |
[Does coffee drinking influence serum uric acid concentration?].
Topics: Adult; Aged; Caffeine; Chi-Square Distribution; Coffee; Female; Humans; Hypertension; Hyperuricemia; | 2004 |
Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy.
Topics: Adult; Blood Coagulation Factor Inhibitors; Chronic Disease; Female; Humans; Hypertension; Hypertens | 2005 |
Gender-specific leptinemia and its relationship with some components of the metabolic syndrome in Moroccans.
Topics: Aged; Blood Glucose; Blood Pressure; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Female; | 2005 |
Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects.
Topics: Aged; Apolipoprotein A-I; Brain Ischemia; Case-Control Studies; Cholesterol; Cholesterol, HDL; Diabe | 2005 |
Can cystatin C be a better marker for the early detection of renal damage in primary hypertensive patients?
Topics: Adult; beta 2-Microglobulin; Biomarkers; Blood Urea Nitrogen; Creatinine; Cystatin C; Cystatins; Dis | 2005 |
Sex-related differences in relations of uric acid to left ventricular hypertrophy and remodeling in Japanese hypertensive patients.
Topics: Aged; Cardiovascular Diseases; Case-Control Studies; Female; Humans; Hypertension; Hypertrophy, Left | 2005 |
Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats.
Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Cholesterol; Creatinine; Enzyme Inhibitors; Heart | 2005 |
Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Female; Humans; Hypertension; Insulin Resistance; Male; | 2005 |
Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat.
Topics: Acetophenones; Adrenocorticotropic Hormone; Allopurinol; Animals; Antihypertensive Agents; Antioxida | 2005 |
[Characteristics of metabolic syndrome in children and adolescents with arterial hypertension].
Topics: Adolescent; Body Mass Index; Child; Cholesterol, HDL; Cholesterol, LDL; Female; Glucose Intolerance; | 2005 |
Clinical manifestations of patients with hyperuricemia.
Topics: Age Distribution; Aged; Arthritis, Gouty; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans | 2004 |
Different antioxidants status, total antioxidant power and free radicals in essential hypertension.
Topics: Adolescent; Adult; Aged; Antioxidants; Blood Pressure; Body Mass Index; Case-Control Studies; Female | 2005 |
Serum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly subjects.
Topics: Aged; Body Mass Index; Brain Ischemia; Case-Control Studies; Female; Humans; Hypertension; Lipids; M | 2005 |
[The fibrinolytic system in uric acid dysmetabolism].
Topics: Diabetes Mellitus; Female; Fibrinolysis; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Uri | 2005 |
Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients?
Topics: Adult; Antihypertensive Agents; Biomarkers; Body Mass Index; Cohort Studies; Diuretics; Female; Foll | 2005 |
Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men.
Topics: Adult; Aged; Blood Pressure; Humans; Hypertension; Japan; Male; Methylenetetrahydrofolate Reductase | 2006 |
Uric acid, left ventricular mass index, and risk of cardiovascular disease in essential hypertension.
Topics: Cardiovascular Diseases; Echocardiography; Female; Follow-Up Studies; Heart Ventricles; Humans; Hype | 2006 |
Serum uric acid is associated with microalbuminuria in prehypertension.
Topics: Albuminuria; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Logistic Models; Male; Mid | 2006 |
Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension.
Topics: Adolescent; Animals; Apolipoprotein A-I; Birth Weight; Blood Pressure; Carotid Arteries; Child; Chil | 2006 |
Uric acid and endothelial dysfunction in essential hypertension.
Topics: Adult; Aged; Biomarkers; Comorbidity; Endothelium, Vascular; Humans; Hypertension; In Vitro Techniqu | 2006 |
Hypertension prevalence, awareness, control and association with metabolic abnormalities in the San Marino population: the SMOOTH study.
Topics: Adult; Age Distribution; Aged; Anthropometry; Awareness; Blood Glucose; Blood Pressure; Cholesterol; | 2006 |
Controversies in cardiology.
Topics: Animals; Diuretics; Humans; Hypertension; Kidney; Male; Rats; Uric Acid | 2006 |
Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study.
Topics: Aged; Brain Ischemia; Cardiovascular Diseases; Case-Control Studies; Cerebral Hemorrhage; Cohort Stu | 2006 |
Nephron number, uric acid, and renal microvascular disease in the pathogenesis of essential hypertension.
Topics: Adolescent; Blood Pressure; Child; Endothelium, Vascular; Humans; Hypertension; Infant, Low Birth We | 2006 |
Effects of low birth weight in 8- to 13-year-old children: implications in endothelial function and uric acid levels.
Topics: Adolescent; Blood Pressure; Body Size; Brachial Artery; Child; Endothelium, Vascular; Female; Follow | 2006 |
Uric acid: an old dog with new tricks?
Topics: Carrier Proteins; Cell Membrane; Humans; Hypertension; Muscle, Smooth, Vascular; Organic Anion Trans | 2006 |
Gender-related association of serum uric acid and left ventricular hypertrophy in hypertension.
Topics: Age Factors; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Case-Control Studies; Female; Hu | 2006 |
The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China.
Topics: Adult; Aged; Alcohol Drinking; China; Cross-Sectional Studies; Female; Gout; Humans; Hypercholestero | 2006 |
High urinary calcium excretion and genetic susceptibility to hypertension and kidney stone disease.
Topics: Adolescent; Adult; Calcium; Creatinine; Family Health; Female; Genetic Predisposition to Disease; Hu | 2006 |
[Relationships between arterial hypertension, metabolic disturbances and uric acid nephropathy].
Topics: Adult; Female; Follow-Up Studies; Heart Rate; Humans; Hypertension; Hyperuricemia; Insulin; Kidney D | 2006 |
The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Cohort Studies; Female; Follow-Up Studies; Glomerula | 2006 |
Hypertension, diuretics, and uric acid.
Topics: Antihypertensive Agents; Antioxidants; Benzimidazoles; Biphenyl Compounds; Cardiovascular System; Di | 2006 |
Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study.
Topics: Atherosclerosis; Black or African American; Cohort Studies; Female; Follow-Up Studies; Humans; Hyper | 2006 |
Uric acid and the development of hypertension: the normative aging study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Follow-Up Studies; Humans; Hypertension; Hyperuricemia; Longi | 2006 |
Plasma uric acid level and risk for incident hypertension among men.
Topics: Age Factors; Aged; Case-Control Studies; Cholesterol; Cohort Studies; Creatinine; Humans; Hypertensi | 2007 |
Hyperuricemia and incidence of hypertension among men without metabolic syndrome.
Topics: Adult; Blood Pressure; Follow-Up Studies; Humans; Hypertension; Hyperuricemia; Incidence; Male; Meta | 2007 |
The role of uric acid in pediatric hypertension.
Topics: Adolescent; Animals; Disease Models, Animal; Gout Suppressants; Humans; Hypertension; Hyperuricemia; | 2007 |
Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats.
Topics: Allopurinol; Animals; Blood Pressure; Carotid Arteries; Cell Proliferation; Cells, Cultured; Heart R | 2006 |
[Gout and diuretics; still an issue].
Topics: Cardiovascular Diseases; Case-Control Studies; Diuretics; Gout; Humans; Hypertension; Incidence; Uri | 2007 |
[Correlation of uric acid, APO-CIII, and apo-E in healthy individuals and patients with coronary heart disease and hypertensive disease].
Topics: Apolipoprotein C-III; Apolipoproteins E; Humans; Hypertension; Male; Myocardial Ischemia; Reference | 2007 |
Treatment of hyperuricemia in essential hypertension.
Topics: Allopurinol; Animals; Clinical Trials as Topic; Enzyme Inhibitors; Hypertension; Hyperuricemia; Rats | 2007 |
Uric acid level and its association with carotid intima-media thickness in patients with hypertension.
Topics: Adult; Carotid Artery Diseases; Carotid Artery, Common; Female; Humans; Hypertension; Hyperuricemia; | 2008 |
High-density lipoprotein cholesterol and insulin resistance are independent and additive markers of left ventricular hypertrophy in essential hypertension.
Topics: Aged; Biomarkers; Blood Pressure Determination; Cholesterol, HDL; Female; Humans; Hypertension; Hype | 2007 |
Metabolic syndrome and ambulatory arterial stiffness index in non-diabetic patients with primary hypertension.
Topics: Albuminuria; Arteries; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein; Cardiovascular Dis | 2007 |
Serum uric acid, the endothelium and hypertension: an association revisited.
Topics: Allopurinol; Endothelium, Vascular; Humans; Hypertension; Uric Acid | 2007 |
Serum uric acid is associated with microvascular function in hypertensive individuals.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Brachial Artery; C-Reactive Protein; Cholesterol, HDL; | 2007 |
Pulse hypertension: a new component of the metabolic syndrome in elderly women?
Topics: Aged; Alcohol Drinking; Antihypertensive Agents; Blood Glucose; Blood Pressure; Coronary Disease; Cr | 2007 |
Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: evidence of lipid peroxidation.
Topics: Antioxidants; Biomarkers; Birth Weight; Blood Pressure; Brazil; Censuses; Child; Cohort Studies; Cro | 2007 |
Prevalence of and risk factors for peripheral arterial disease in the patients with hypertension among Han Chinese.
Topics: Adult; Aged; Asian People; Blood Pressure; Cardiovascular Diseases; Case-Control Studies; China; Cho | 2007 |
Association between serum uric acid and prehypertension among US adults.
Topics: Adult; Cross-Sectional Studies; Humans; Hypertension; Middle Aged; United States; Uric Acid | 2007 |
Xanthine oxidoreductase polymorphisms: influence in blood pressure and oxidative stress levels.
Topics: Blood Pressure; Case-Control Studies; Diastole; Female; Haplotypes; Humans; Hypertension; Male; Nucl | 2007 |
[Metabolic and anthropometric profile of Aruák Indians: Mehináku, Waurá and Yawalapití in the Upper Xingu, Central Brazil, 2000-2002].
Topics: Adult; Anthropometry; Body Constitution; Brazil; Chronic Disease; Dyslipidemias; Female; Humans; Hyp | 2007 |
Status of uric acid management in hypertensive subjects.
Topics: Aged; Aged, 80 and over; Cardiology; Cross-Sectional Studies; Enzyme Inhibitors; Female; Humans; Hyp | 2007 |
Serum uric acid is significantly related to the components of the metabolic syndrome in Japanese workingmen.
Topics: Adult; Biomarkers; Blood Glucose; C-Reactive Protein; Cross-Sectional Studies; Dyslipidemias; Employ | 2007 |
Association between serum uric acid levels and coronary flow reserve in hypertensive patients without concomitant risk factors.
Topics: Adult; Cardiovascular Diseases; Cohort Studies; Coronary Circulation; Coronary Vessels; Echocardiogr | 2007 |
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Diuretics; Fructose; Gout Suppressants; Hydrochlo | 2007 |
Sympathoadrenergic and metabolic factors are involved in ambulatory blood pressure rise in childhood obesity.
Topics: Adolescent; Albuminuria; Aldosterone; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Ma | 2008 |
Serum uric acid is independently associated with hypertension in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Hypertension; Logistic Models; Male; Middle Aged; Predictive | 2008 |
For the patient. Obesity, uric acid, and high blood pressure.
Topics: Adult; Black People; Female; Humans; Hypertension; Obesity; South Africa; Uric Acid; White People | 2007 |
The relationship between obesity and transforming growth factor beta on renal damage in essential hypertension.
Topics: Adult; Albuminuria; Blood Glucose; Body Mass Index; Case-Control Studies; Creatinine; Female; Humans | 2007 |
Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study.
Topics: Aged; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Dyslipidemias; Follow-Up Studies; | 2008 |
Efficacy and safety of long-term losartan therapy demonstrated by a prospective observational study in Japanese patients with hypertension: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Bl | 2008 |
Serum uric acid levels and risk of metabolic syndrome in healthy adults.
Topics: Adult; Biomarkers; Cross-Sectional Studies; Female; Humans; Hypertension; Hypertriglyceridemia; Hype | 2008 |
Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Creatinine; Desoxycorticosterone; Disease M | 2008 |
[Saluresis in the treatment of hypertension].
Topics: Carbohydrate Metabolism; Diet, Sodium-Restricted; Diuretics; Humans; Hypertension; Hypokalemia; Pota | 1966 |
Assessing the coronary profile.
Topics: Adult; Aged; Blood Pressure Determination; Body Height; Body Weight; Cholesterol; Coronary Disease; | 1967 |
Relationships between toxemia of pregnancy and essential hypertension in a total community.
Topics: Adolescent; Adult; Blood Glucose; Child; Child, Preschool; Cholesterol; Eclampsia; Female; Glucose T | 1967 |
[Clinical experience with prolonged treatment of elderly patients with an oral diuretic: trichlormethiazide. Observations on pressure behavior, electrolyte levels and blood urea, uric acid and glucide metabolism].
Topics: Aged; Blood Glucose; Blood Urea Nitrogen; Electrolytes; Female; Humans; Hypertension; Male; Trichlor | 1967 |
Salivary electrolytes, urea nitrogen, uric acid and salt taste thresholds in hypertension.
Topics: Aldosterone; Chlorine; Citrates; Humans; Hypertension; Parotid Gland; Potassium; Saliva; Secretory R | 1967 |
[Arterial hypertension and uricemia].
Topics: Adult; Aged; Arteriosclerosis; Cholesterol; Female; Humans; Hypertension; Male; Middle Aged; Oxalate | 1967 |
[The behavior of uricemia during treatment with spironolactone and with other diuretics].
Topics: Acetazolamide; Adolescent; Adult; Aged; Chlorthalidone; Clopamide; Diuretics; Ethacrynic Acid; Femal | 1967 |
Diuretics, hyperuricaemia, and tienilic acid.
Topics: Benzothiadiazines; Diuretics; Glycolates; Humans; Hypertension; Kidney; Liver; Risk; Sodium Chloride | 1980 |
[Treatment of hypertension in pregnant women with beta-blockers. 60 cases (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Apgar Score; Birth Weight; Female; Heart Rate; Humans; Hypertens | 1980 |
Hypertension and uric acid.
Topics: Humans; Hypertension; Uric Acid; Vascular Diseases | 1981 |
Effect of long-term treatment with beta-blocking drugs on plasma lipids and lipoproteins.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cholesterol; Female; Humans; Hypertension; Lipoproteins, H | 1981 |
Beta adrenergic blocking agents to control hypertension in aviation personnel.
Topics: Adrenergic beta-Antagonists; Adult; Aerospace Medicine; Atenolol; Humans; Hypertension; Male; Middle | 1982 |
Serum uric acid levels as an index of fetal prognosis in pregnancies complicated by pre-existing hypertension and pre-eclampsia of pregnancy.
Topics: Birth Weight; Estrogens; Female; Fetal Distress; Fetal Growth Retardation; Humans; Hypertension; Inf | 1982 |
[Changes in serum lipids during drug therapy of hypertension].
Topics: Adrenergic beta-Antagonists; Diuretics; Drug Therapy, Combination; Growth Hormone; Humans; Hypertens | 1982 |
Beta blocker therapy in 125 cases of hypertension during pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenergic beta-Antagonists; Adult; Apgar Score; Bicarbonates; Birth We | 1983 |
The use of diuretics in modern antihypertensive therapy.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Glucose Tolera | 1984 |
Inherited salt sensitivity in normotensive humans as a cause of essential hypertension: a new concept.
Topics: Adult; Biological Transport, Active; Blood Pressure; Diet; Humans; Hypertension; Ion Channels; Male; | 1984 |
The impact on serum lipids of combinations of diuretics and beta-blockers and of beta-blockers alone.
Topics: Adrenergic beta-Antagonists; Cholesterol, HDL; Diuretics; Drug Therapy, Combination; Humans; Hydroch | 1984 |
Coincidence of cerebrovascular accident and silent myocardial infarction.
Topics: Adult; Arterial Occlusive Diseases; Bundle-Branch Block; Cardiomegaly; Cerebral Angiography; Cerebra | 1982 |
Casual blood pressure: its relationship to several cardiovascular risk factors in middle-aged men.
Topics: Blood Glucose; Body Weight; Cardiomegaly; Cardiovascular Diseases; Cholesterol; Cross-Sectional Stud | 1984 |
[A longitudinal study of secondary prevention of heart infarct].
Topics: Aftercare; Aged; Blood Glucose; Female; Humans; Hyperlipidemias; Hypertension; Longitudinal Studies; | 1983 |
The effect of spironolactone on lipid, glucose and uric acid levels in blood during long-term administration to hypertensives.
Topics: Adult; Blood Glucose; Fasting; Growth Hormone; Humans; Hypertension; Insulin; Lipids; Male; Middle A | 1983 |
Cardiovascular changes after weight reduction in obesity hypertension.
Topics: Blood Pressure; Body Weight; Diet, Reducing; Diet, Sodium-Restricted; Female; Hemodynamics; Humans; | 1983 |
Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension.
Topics: Adult; Aldosterone; Female; Humans; Hypertension; Plasma Volume; Pregnancy; Pregnancy Complications, | 1983 |
Metabolic parameters after changing from hydrochlorothiazide to verapamil treatment in hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; C-Peptide; Creatinine; Fatty Acids, Nonesterified; Femal | 1984 |
[Renin-angiotensin-aldosterone system, blood volume, serum uric acid and urinary excretion of prostaglandins and kallikrein in the arterial hypertension induced by pregnancy].
Topics: Blood Pressure; Blood Volume; Female; Humans; Hypertension; Kallikreins; Pregnancy; Pregnancy Compli | 1984 |
Clinical manifestations and diagnosis of pregnancy-induced hypertension.
Topics: Angiotensin II; Antigens; Antithrombin III; Bed Rest; Diastole; Endothelium; Factor VIII; Female; Hu | 1984 |
[Cardiovascular diseases after kidney transplantation: an analysis of predisposing factors].
Topics: Cardiomegaly; Cardiovascular Diseases; Cholesterol; Female; Humans; Hyperparathyroidism; Hypertensio | 1981 |
[Is hyperuricemia a risk factor?].
Topics: Adolescent; Adult; Alcohol Drinking; Alcoholism; Body Weight; Cholesterol; Female; Humans; Hungary; | 1984 |
Reversible cerebral ischemias: a comparative analysis of risk factors in TIAs and in RINDs.
Topics: Atrial Fibrillation; Brain Ischemia; Female; Hematocrit; Humans; Hypercholesterolemia; Hypertension; | 1984 |
[How to treat hyperuricemia?].
Topics: Arthritis, Rheumatoid; Humans; Hypertension; Kidney Calculi; Kidney Diseases; Risk; Uric Acid | 1984 |
Side effects of systemic cyclosporine in patients not undergoing transplantation.
Topics: Adolescent; Adult; Aged; Anemia; Autoimmune Diseases; Blood Sedimentation; Chemical and Drug Induced | 1984 |
[Hyperuricemia in ischemic heart disease].
Topics: Adult; Body Weight; Coronary Disease; Diuretics; Gout; Humans; Hyperlipoproteinemias; Hypertension; | 1984 |
Management of patients with a diastolic blood pressure of 90 mmHg in the third trimester of pregnancy.
Topics: Blood Pressure; Diastole; Female; Humans; Hypertension; Pregnancy; Pregnancy Complications; Pregnanc | 1984 |
[Angina pectoris in patients with arterial hypertension aged 40-59 years. I. Incidence and risk factors].
Topics: Adult; Angina Pectoris; Humans; Hypercholesterolemia; Hyperglycemia; Hypertension; Male; Middle Aged | 1984 |
Hypotensive and uric acid-retaining effects of trichlormethiazide under dietary sodium restriction in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Drinking; Electrolytes; Hematocrit; H | 1984 |
Risk grouping of 113 patients with hypertensive disorders during pregnancy, with respect to serum urate, proteinuria and time of onset of hypertension.
Topics: Adult; Antihypertensive Agents; Female; Humans; Hypertension; Maternal Age; Pregnancy; Pregnancy Com | 1984 |
Plasma volume findings in patients with mild pregnancy-induced hypertension.
Topics: Adult; Creatinine; Female; Humans; Hypertension; Infant, Newborn; Infant, Small for Gestational Age; | 1983 |
Concentrations of hypoxanthine, xanthine, uridine and urate in amniotic fluid at caesarean section and the association of raised levels with prenatal risk factors and fetal distress.
Topics: Amniotic Fluid; Cesarean Section; Female; Fetal Distress; Fetal Hypoxia; Humans; Hypertension; Hypox | 1983 |
Diuretic treatment in essential hypertension.
Topics: Aged; Arrhythmias, Cardiac; Blood Glucose; Diuretics; Dose-Response Relationship, Drug; Hemodynamics | 1983 |
[Arterial hypertension in men aged 40-59 years. III. Mean uric acid level in the serum of hyper- and normotensive persons. Relation between uric acid level and arterial blood pressure, duration of illness, age, cholesterol level and body weight].
Topics: Adult; Age Factors; Blood Pressure; Body Weight; Cholesterol; Humans; Hypertension; Male; Middle Age | 1983 |
[Arterial hypertension in men aged 40-59 years. IV. Relation between uric acid and potassium and creatinine concentrations in the serum of hyper- and normotensive persons].
Topics: Adult; Blood Pressure; Humans; Hyperkalemia; Hypertension; Male; Middle Aged; Potassium; Uric Acid | 1983 |
Serum uric acid in mild essential hypertension.
Topics: Adult; Aged; Combined Modality Therapy; Diet, Sodium-Restricted; Diuretics; Female; Humans; Hydralaz | 1983 |
A prospective study of the development of hypertension and renal stone disease in subjects with increased blood urate.
Topics: Allopurinol; Blood Pressure; Female; Humans; Hypertension; Kidney Calculi; Male; Middle Aged; Prospe | 1983 |
Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.
Topics: Adult; Blood Circulation; Blood Glucose; Cholesterol; Diuretics; Drug Administration Schedule; Heart | 1983 |
Study on the detection and epidemiology of risk factors in ischemic cardiopathy in some localities of Bihor county.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Coronary Disease; Diabetes Complications; Female; | 1983 |
Step-down treatment of mild systemic hypertension.
Topics: Adult; Blood Glucose; Chlorthalidone; Drug Administration Schedule; Female; Humans; Hypertension; Li | 1984 |
Safety and effectiveness of weight reduction using a very-low-calorie formulated food.
Topics: Blood Proteins; Body Weight; Cholesterol; Diet, Reducing; Electrolytes; Food, Formulated; Humans; Hy | 1984 |
Changes in blood chemistry in hypertensive patients during propranolol therapy.
Topics: Adult; Blood Proteins; Cholesterol; Creatinine; Female; Humans; Hypertension; Male; Middle Aged; Pro | 1984 |
The management of hyperuricaemia.
Topics: Adult; Aged; Follow-Up Studies; Gout; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Myoc | 1984 |
Diversity of clinical features in gouty arthritis.
Topics: Adolescent; Adult; Age Factors; Aged; Arthritis; Child; Female; Gout; Humans; Hyperlipidemias; Hyper | 1984 |
Exercise and risk factors for arteriosclerosis in 42 married couples followed over four years.
Topics: Adult; Aged; Arteriosclerosis; Blood Glucose; Body Weight; Cholesterol; Female; Follow-Up Studies; H | 1984 |
Cerebral blood flow changes with diuretic therapy in elderly subjects with systolic hypertension.
Topics: Aged; Angiotensin II; Blood Pressure; Cerebrovascular Circulation; Humans; Hydrochlorothiazide; Hype | 1982 |
Renal effects of acute calcium blockade with nifedipine in hypertensive patients receiving beta-adrenoceptor-blocking drugs.
Topics: Adult; Albuminuria; beta 2-Microglobulin; Blood Pressure; Female; Heart Rate; Humans; Hypertension; | 1982 |
Renin angiotensin aldosterone system and adrenergic system in normotensive and hypertensive pregnancy.
Topics: Adult; Aldosterone; Epinephrine; Female; Humans; Hypertension; Norepinephrine; Pregnancy; Pregnancy | 1982 |
Accelerated atherosclerosis in patients on maintenance dialysis.
Topics: Adult; Arteriosclerosis; Blood Platelets; Diabetes Mellitus; Female; Humans; Hypertension; Kidney Fa | 1980 |
[The hypothyroid rheumatic syndrome in the strict sense (author's transl)].
Topics: Adult; Aged; Diabetes Complications; Female; Humans; Hypertension; Hypothyroidism; Male; Middle Aged | 1980 |
[Metabolic effects of diuretics (author's transl)].
Topics: Benzothiadiazines; Blood Glucose; Diuretics; Energy Metabolism; Humans; Hypertension; Lipids; Sodium | 1981 |
[Changes in blood pressure figures after a 5-year interval. Analysis of factors for predicting future hypertensives].
Topics: Adult; Age Factors; Blood Pressure; Body Weight; Cholesterol; Female; Heart Rate; Humans; Hypertensi | 1982 |
[The renin-angiotensin-aldosterone system and the adrenergic system in normal pregnancy and hypertension induced by pregnancy].
Topics: Aldosterone; Epinephrine; Female; Humans; Hypertension; Norepinephrine; Pregnancy; Pregnancy Complic | 1982 |
Risk factor modification in the framework of rehabilitation. Results of a long-term rehabilitation program in Bavaria.
Topics: Cholesterol; Exercise Therapy; Germany, West; Humans; Hypertension; Long-Term Care; Myocardial Infar | 1982 |
Combined diuretic and sympatholytic therapy in elderly patients with predominant systolic hypertension.
Topics: Aged; Blood Pressure; Chlorthalidone; Clonidine; Drug Combinations; Humans; Hypertension; Kidney; Ma | 1983 |
[Hyperuricemia in essential hypertension. Considerations on some pathogenic aspects].
Topics: Glomerular Filtration Rate; Humans; Hypertension; Uric Acid | 1983 |
Metabolic consequences of antihypertensive therapy.
Topics: Antihypertensive Agents; Blood Glucose; Carbohydrate Metabolism; Hormones; Humans; Hydrochlorothiazi | 1983 |
[Risk factors in cerebrovascular disease. A study of 162 patients].
Topics: Aged; Alcoholism; Cerebrovascular Disorders; Diabetes Complications; Female; Heart Diseases; Humans; | 1983 |
[Serum uric acid as a prognostic parameter in prenatal monitoring of gestoses].
Topics: Female; Fetal Death; Fetal Monitoring; Gestational Age; Humans; Hypertension; Obstetric Labor Compli | 1983 |
[The value of a single determination of serum uric acid concentration in the early diagnosis of hypertensive disorders in pregnancy (author's transl)].
Topics: Adolescent; Adult; Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, | 1982 |
[Anti-hypertensive efficacy and metabolic effects of fenquizone after a year's treatment].
Topics: Adult; Aged; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Potassium; Quinazolines; Time | 1982 |
Modern management of hypertension in pregnancy.
Topics: Antihypertensive Agents; Female; Fetal Monitoring; Gestational Age; Hematocrit; Humans; Hypertension | 1980 |
Hemodynamic and metabolic long-term effects of tienilic acid in essential hypertension.
Topics: Adult; Blood Pressure; Cardiac Output; Chlorides; Creatinine; Diabetes Mellitus; Glycolates; Heart R | 1981 |
Serum uric acid as a marker of pregnancy-induced hypertension.
Topics: Adult; Female; Humans; Hypertension; Longitudinal Studies; Pre-Eclampsia; Pregnancy; Pregnancy Compl | 1982 |
[Levels of cholesterol, triglycerides, uric acid and glucose following prolonged treatment of hypertension with low and normal renin activity with hydrochlorothiazide].
Topics: Adult; Blood Glucose; Cholesterol; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Renin; Tr | 1981 |
Serum uric acid as a risk factor for stroke in a fishing village of rural southern Japan.
Topics: Aged; Cerebrovascular Disorders; Electrocardiography; Fisheries; Humans; Hypertension; Japan; Lipopr | 1982 |
The relationship of serum uric acid to hypertension and ischemic heart disease in Hisayama population, Japan.
Topics: Alcohol Drinking; Coronary Disease; Diabetes Mellitus; Female; Humans; Hypertension; Japan; Male; Re | 1982 |
Pulse pressure-I. Level and associated factors in four Chicago epidemiologic studies.
Topics: Adolescent; Adult; Age Factors; Black or African American; Blood Glucose; Blood Pressure; Body Weigh | 1982 |
[Hypertension and hyperuricemia: how are they related?].
Topics: Antihypertensive Agents; Cardiovascular Diseases; Female; Humans; Hypertension; Male; Renal Circulat | 1982 |
[Laboratory findings in the "Vienna Health Study 79" (author's transl)].
Topics: Adult; Aged; Austria; Blood Glucose; Cholesterol; Cholesterol, HDL; Coronary Disease; Diabetes Melli | 1982 |
[The cardiovascular risk profile of the long-term diabetic].
Topics: Cardiovascular Diseases; Diabetes Complications; Humans; Hypercholesterolemia; Hypertension; Middle | 1982 |
Erythrocyte sedimentation rate and cardiovascular disease. Results from a population study of women in Göteborg, Sweden.
Topics: Adult; Angina Pectoris; Blood Sedimentation; Cardiovascular Diseases; Cerebrovascular Disorders; Cho | 1982 |
Evaluation of hemofiltration with different AN 69 membrane devices using a discontinuous flow-single needle system.
Topics: Acrylic Resins; Acrylonitrile; Adult; Blood; Creatine; Female; Glomerulonephritis; Hemolysis; Humans | 1982 |
Antihypertensive drugs and blood lipids: the Oslo study.
Topics: Adult; Antihypertensive Agents; Drug Therapy, Combination; Humans; Hypertension; Lipids; Male; Middl | 1982 |
Hyperuricemia.
Topics: Arthritis; Female; Gout; Humans; Hypertension; Kidney Calculi; Male; Uric Acid | 1982 |
[Diuretic treatment and serum lipoproteins: effects of tienilic acid and indapamide (author's transl)].
Topics: Cholesterol; Cholesterol, LDL; Diuretics; Glycolates; Humans; Hypertension; Indapamide; Lipoproteins | 1982 |
Allantoxanamide-induced myocardial necrosis in Sprague-Dawley vs spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Corticosterone; Female; He | 1982 |
[Epidemiology and diagnosis of hypertension in the Upper-Silesian industrial region. IV. Serum uric acid level in normotensive and hypertensive persons in the industrialized and non-industrialized regions].
Topics: Adult; Age Factors; Blood Pressure; Environmental Health; Female; Humans; Hypertension; Male; Middle | 1982 |
[Extraarticular diseases and findings in gout].
Topics: Arteriosclerosis; Diabetes Complications; Female; Gout; Humans; Hyperlipoproteinemias; Hypertension; | 1982 |
The use of diuretics in hypertension.
Topics: Benzothiadiazines; Carbohydrate Metabolism; Diuretics; Dose-Response Relationship, Drug; Humans; Hyp | 1982 |
Changes in intrarenal uric acid handling during chronic spironolactone treatment in patients with essential hypertension.
Topics: Body Weight; Chlorthalidone; Female; Humans; Hypertension; Kidney; Male; Spironolactone; Uric Acid | 1982 |
Plasma volume determination in pregnancies complicated by chronic hypertension and intrauterine fetal demise.
Topics: Adult; Blood Pressure; Body Surface Area; Creatinine; Female; Fetal Death; Fetal Growth Retardation; | 1982 |
Medical student response to a class lipid-screening project.
Topics: Adolescent; Adult; Cholesterol; Coronary Disease; Female; Health Surveys; Humans; Hypertension; Male | 1982 |
Plasma noradrenaline and adrenaline levels in normal pregnancy and in pregnancy-induced hypertension.
Topics: Adult; Epinephrine; Female; Humans; Hypertension; Longitudinal Studies; Norepinephrine; Pregnancy; P | 1982 |
[Hyperuricemia, gout and ischemic disease of the coronary arteries of the heart].
Topics: Coronary Disease; Gout; Humans; Hypertension; Lipids; Male; Middle Aged; Uric Acid | 1982 |
[Long-term side-effects of diuretics in the treatment of hypertension (author's transl)].
Topics: Blood Glucose; Diuretics; Humans; Hypertension; Hypokalemia; Potassium; Retrospective Studies; Trigl | 1981 |
[Incidence of metabolic disorders in patients with recurrent urinary calculi].
Topics: Adult; Aged; Calcium Oxalate; Creatinine; Diabetes Complications; Electrolytes; Female; Humans; Hydr | 1981 |
Metabolism of uric acid in normal and pathologic pregnancy.
Topics: Female; Fetal Growth Retardation; Humans; Hypertension; Pregnancy; Pregnancy Complications; Pregnanc | 1981 |
Uric acid in childhood essential hypertension.
Topics: Adolescent; Adult; Cardiovascular Diseases; Child; Child, Preschool; Diet, Sodium-Restricted; Female | 1981 |
Selected physiologic and drug effects on serum uric acid levels in an elderly population.
Topics: Aged; Allopurinol; Diuretics; Female; Humans; Hypertension; Male; Obesity; Probenecid; Thyroid Disea | 1981 |
[Comments on a series of 38 cases of primary hyperparathyroidism (author's transl)].
Topics: Adult; Aged; Bone Diseases; Calcium Phosphates; Female; Humans; Hypercalcemia; Hyperparathyroidism; | 1981 |
[Metabolic risk factors in the very old].
Topics: Aged; Aging; Cardiovascular Diseases; Coronary Disease; Diabetes Complications; Female; Humans; Hype | 1981 |
Uric acid levels and renal blood flow.
Topics: Humans; Hypertension; Kidney; Regional Blood Flow; Uric Acid | 1981 |
Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats.
Topics: Animals; Arteries; Arteriosclerosis; Blood Glucose; Blood Pressure; Body Weight; Corticosterone; Cre | 1981 |
[Advances in the treatment of gout and hyperuricemia].
Topics: Anti-Inflammatory Agents; Female; Gout; Humans; Hypertension; Kidney Calculi; Kidney Diseases; Male; | 1981 |
[The cardiovascular risk profile in patients with disorders of glucose tolerance (borderline diabetes) dependent on the heredity of the diabetes].
Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Glucose Tolerance Test; Humans; | 1981 |
[Metabolic effects of long-term use of thiazide diuretics (author's transl)].
Topics: Adult; Aged; Benzothiadiazines; Calcium; Cholesterol; Diuretics; Female; Humans; Hypertension; Male; | 1981 |
Assessment of natriuretic drugs.
Topics: Body Water; Diuretics; Humans; Hypertension; Kidney Diseases; Kidney Tubules; Male; Natriuresis; Sod | 1981 |
[Significance of uric acid concentration in the serum for the early recognition of the risk of EPH gestosis].
Topics: Eclampsia; Female; Humans; Hypertension; Placental Insufficiency; Pre-Eclampsia; Pregnancy; Uric Aci | 1981 |
[Frequency of risk factors in cerebrovascular disease and their effect on the course and outcome. Study on 423 hospitalized patients].
Topics: Aged; Aging; Arrhythmias, Cardiac; Cerebrovascular Disorders; Coronary Disease; Diabetes Complicatio | 1981 |
[The influence of diabetes heredity on cardiovasculary risk profile in patients with high age diabetes (author's transl)].
Topics: Aged; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus; Female; Humans; Hypertension; Male; R | 1981 |
[The cardiovascular risk profile in persons with normal glucose tolerance with reference to the familial occurrence of diabetes mellitus].
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Diabetes Mellitus; Female; Glucose Tolerance Test; | 1981 |
[Cardiovascular diseases in Vienna. Epidemiological results of the "Vienna Health Study 1979"].
Topics: Adult; Austria; Cardiovascular Diseases; Cerebrovascular Disorders; Cholesterol; Coronary Disease; F | 1981 |
High uric acid as an indicator of cardiovascular disease. Independence from obesity.
Topics: Aged; Body Weight; Cardiovascular Diseases; Coronary Disease; Female; Follow-Up Studies; Gout; Human | 1980 |
Maternal and umbilical plasma concentrations of uric acid and oxypurines at delivery in normal and hypertensive pregnancy.
Topics: Female; Fetal Blood; Humans; Hypertension; Infant, Newborn; Labor, Obstetric; Pregnancy; Pregnancy C | 1980 |
[Clinical biochemical changes in ischemic heart disease: hyperuricemia as a risk factor].
Topics: Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Cholesterol; Chronic Disease; Coronary Disease; | 1980 |
Renal lesions in the hypertensive syndromes of pregnancy: immunomorphological and ultrastructural studies in 114 cases.
Topics: Adult; Female; Humans; Hypertension; Kidney; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Card | 1980 |
Body weight change in relation to incidence of ischemic heart disease and change in risk factors for ischemic heart disease.
Topics: Adult; Aged; Angina Pectoris; Blood Glucose; Blood Pressure; Body Weight; Coronary Disease; Diabetes | 1980 |
A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension.
Topics: Adolescent; Adult; Aged; Amiloride; Blood Chemical Analysis; Blood Pressure; Body Weight; Drug Thera | 1980 |
[A case of primary hypouricosuric gout associated with mental retardation, self-mutilation and salt dependent hypertension (author's transl)].
Topics: Adolescent; Gout; Humans; Hypertension; Intellectual Disability; Male; Self Mutilation; Uric Acid | 1980 |
[Blood cadmium level in coronary disease depending on the risk factors].
Topics: Adult; Aged; Cadmium; Coronary Disease; Diabetes Mellitus; Humans; Hyperlipidemias; Hypertension; Mi | 1980 |
The prevalence of ischaemic heart disease risk factors in middle-aged White miners.
Topics: Blood Glucose; Body Weight; Cholesterol; Coronary Disease; Humans; Hypertension; Male; Middle Aged; | 1980 |
Tienilic acid in the treatment of gout and hypertension.
Topics: Adult; Blood Chemical Analysis; Blood Pressure; Creatinine; Glycolates; Gout; Humans; Hypertension; | 1980 |
Clinical features of 4,000 gouty subjects in Japan.
Topics: Adult; Age Factors; Female; Gout; Humans; Hypertension; Japan; Kidney Failure, Chronic; Male; Middle | 1980 |
[Epidemiology and clinical aspects of hyperuricemia and gout].
Topics: Aged; Alcohol Drinking; Blood Pressure; Body Weight; Diagnosis, Differential; Feeding Behavior; Gout | 1980 |
Controlled inpatient study of tienilic acid in treatment of gout and hypertension.
Topics: Blood Pressure; Drug Administration Schedule; Glycolates; Gout; Humans; Hypertension; Ticrynafen; Ur | 1980 |
Tienilic acid: a single treatment for hyperuricaemia and hypertension?
Topics: Adult; Aged; Blood Pressure; Glycolates; Gout; Humans; Hypertension; Male; Middle Aged; Ticrynafen; | 1980 |
[Clinical risk factors in transient global amnesia and in transient ischaemic attacks (author's transl)].
Topics: Adult; Aged; Amnesia; Diabetes Complications; Female; Heart Failure; Humans; Hypercholesterolemia; H | 1980 |
Effects of mefruside treatment in hypertension.
Topics: Aged; Blood Glucose; Cholesterol; Diuretics; Female; Humans; Hypertension; Male; Mefruside; Middle A | 1980 |
Serum uric acid in essential hypertension: an indicator of renal vascular involvement.
Topics: Adult; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Nephrosclerosis; Regional Blo | 1980 |
Asymptomatic mild hyperuricaemia: an indicator of nephrosclerosis in essential hypertension.
Topics: Adult; Blood Flow Velocity; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Nephrosc | 1980 |
[Gout as a joint disease and as a generalized disease. Incidence, diagnosis and therapy].
Topics: Allopurinol; Colchicine; Diabetes Complications; Gout; Humans; Hypertension; Indomethacin; Kidney Di | 1980 |
[Associated cardiovascular factors of risk in borderline-diabetes (author's transl)].
Topics: Adult; Aged; Cholesterol; Diabetes Complications; Female; Glucose Tolerance Test; Humans; Hyperlipop | 1980 |
Complications of antihypertensive therapy.
Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydr | 1981 |
Changes in population cholesterol concentrations and other cardiovascular risk factor levels after five years of the non-communicable disease intervention programme in Mauritius. Mauritius Non-communicable Disease Study Group.
Topics: Adult; Aged; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Cholesterol; Cross-Sectional | 1995 |
[Study of associated risk factors and prevalence of heart diseases in patients with arterial hypertension].
Topics: Aged; Alcohol Drinking; Atrial Fibrillation; Coronary Disease; Data Interpretation, Statistical; Dia | 1995 |
Role of blood pressure, uric acid, and hemorheological parameters on plasma homocyst(e)ine concentration.
Topics: Blood Flow Velocity; Blood Pressure; Hematocrit; Homocysteine; Humans; Hypertension; Male; Middle Ag | 1995 |
Stroke and alcohol intake in a hospital population. A case-control study.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholism; Aspartate Aminotransferases; Biomarker | 1995 |
Serum uric acid and hypertension: the Olivetti heart study.
Topics: Adult; Humans; Hypertension; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Uric Acid | 1994 |
[Gout tophi and Heberden nodules in hyperuricemia].
Topics: Aged; Aged, 80 and over; Arthritis, Gouty; Female; Fingers; Gout; Hand Deformities, Acquired; Humans | 1994 |
Hyperuricaemia and perinatal outcome in pregnancy induced hypertension.
Topics: Female; Humans; Hypertension; Matched-Pair Analysis; Pregnancy; Pregnancy Complications, Cardiovascu | 1994 |
Familial hyperuricemic nephropathy.
Topics: Adolescent; Adult; Child; Family Health; Female; Genes, Dominant; Gout; Humans; Hypertension; Kidney | 1995 |
Antioxidant status in controlled and uncontrolled hypertension and its relationship to endothelial damage.
Topics: Adult; Aged; Analysis of Variance; Antihypertensive Agents; Antioxidants; Arteriosclerosis; Ascorbic | 1994 |
Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women.
Topics: Apolipoprotein A-I; Apolipoprotein A-II; Case-Control Studies; Cholesterol; Epoprostenol; Female; Hu | 1995 |
Renal function in gout patients.
Topics: Arthritis, Gouty; Biopsy; Humans; Hypertension; Kidney; Male; Middle Aged; Ultrasonography; Uric Aci | 1995 |
Hypertension and alcoholism.
Topics: Adult; Alcoholism; Biomarkers; Erythrocyte Indices; gamma-Glutamyltransferase; Humans; Hungary; Hype | 1993 |
Behavioural and biological correlates of serum uric acid: a study of self-defence officials in Japan.
Topics: Aged; Alcohol Drinking; Body Weight; Creatinine; Diabetes Mellitus; Humans; Hyperlipidemias; Hyperte | 1994 |
The duration of hypertension in the puerperium of preeclamptic women: relationship with renal impairment and week of delivery.
Topics: Adult; Blood Pressure; Female; Gestational Age; Humans; Hypertension; Kidney Diseases; Parity; Postp | 1994 |
Erythrocyte Na+,K+,Cl- cotransport and kidney function in essential hypertension.
Topics: Adult; Carrier Proteins; Erythrocytes; Female; Furosemide; Humans; Hypertension; Kidney; Male; Middl | 1993 |
The relationship of erythrocyte sodium-lithium countertransport to blood pressure and metabolic abnormalities in a sample of untreated middle-aged male workers.
Topics: Adult; Anthropometry; Antiporters; Blood Pressure; Body Mass Index; Erythrocytes; Humans; Hypertensi | 1993 |
[Role of aldosterone in essential arterial hypertension complicated by chronic renal insufficiency].
Topics: Adrenocorticotropic Hormone; Aged; Aldosterone; Blood Pressure; Cations; Creatinine; Female; Humans; | 1993 |
Management of severe, early pre-eclampsia: is conservative management justified?
Topics: Birth Weight; Blood Pressure; Dexamethasone; Female; Humans; Hypertension; Infant Mortality; Infant, | 1993 |
Thiazide therapy for diabetes.
Topics: Benzothiadiazines; Diabetic Angiopathies; Diuretics; Glucose; Glucose Tolerance Test; Humans; Hypert | 1994 |
Changes in insulin and lipid metabolism in males with asymptomatic hyperuricaemia.
Topics: Adult; Analysis of Variance; Blood Glucose; Case-Control Studies; Humans; Hyperinsulinism; Hyperlipi | 1993 |
[Value of oxypurines and uric acid in plasma, renal excretion of oxypurines and uric acid as well as plasma adenosine deaminase and AMP deaminase activity in patients with essential hypertension].
Topics: Adenosine Deaminase; Adult; AMP Deaminase; Female; Humans; Hypertension; Hypoxanthine; Hypoxanthines | 1993 |
Calcium metabolism, plasma parathyroid hormone, and calcitriol in transient hypertension of pregnancy.
Topics: Adult; Blood Pressure; Calcitriol; Calcium; Carrier Proteins; Dicarboxylic Acid Transporters; Female | 1993 |
[Hyperuricemia and atherosclerosis].
Topics: Aged; Arteriosclerosis; Diet, Atherogenic; Gout; Humans; Hyperinsulinism; Hyperlipidemias; Hypertens | 1993 |
Placental bed lesions and infant birth weight in hypertensive pregnant women.
Topics: Adult; Arteriosclerosis; Birth Weight; Creatinine; Female; Gestational Age; Humans; Hypertension; In | 1995 |
[Kidney function in pregnant women with arterial hypertension].
Topics: Adult; Blood Proteins; Case-Control Studies; Female; Humans; Hypertension; Kidney Function Tests; Pr | 1995 |
[Transmembrane Na+ transport kinetics in arterial hypertension: relations with vascular risk parameters].
Topics: Adult; Biological Transport, Active; Blood Glucose; Cardiovascular Diseases; Cholesterol, LDL; Creat | 1995 |
Clustering of dyslipidemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Atherosclerosis Risk in Communities Study Investigators.
Topics: Cluster Analysis; Diabetes Complications; Diabetes Mellitus; Humans; Hyperlipidemias; Hypertension; | 1996 |
Does industrial environment influence the prevalence of arterial hypertension, plasma cholesterol and uric acid concentration and activity of the renin-aldosterone system?
Topics: Adult; Aldosterone; Cholesterol; Environmental Monitoring; Environmental Pollution; Epidemiological | 1996 |
Prevalence and risk factors for micro- and macroalbuminuria in an Italian population-based cohort of NIDDM subjects.
Topics: Aged; Albuminuria; Blood Glucose; Blood Pressure; Cohort Studies; Diabetes Mellitus, Type 2; Diabeti | 1996 |
A metabolic syndrome in whites and African-Americans. The Atherosclerosis Risk in Communities baseline study.
Topics: Arteriosclerosis; Black People; Cholesterol, HDL; Cluster Analysis; Diabetes Mellitus; Ethnicity; Fe | 1996 |
Influence of cyclosporine A and FK506 on 24 h blood pressure monitoring in kidney transplant recipients.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood Urea Ni | 1996 |
Results of long-term medical treatment of patients with arterial hypertension complicated by aortic dissection.
Topics: Adult; Aged; Angiography, Digital Subtraction; Antihypertensive Agents; Aortic Aneurysm; Aortic Diss | 1995 |
[Arterial hypertension and diabetes in Ouagadougou (Burkina Faso)].
Topics: Adult; Aged; Burkina Faso; Diabetes Complications; Diabetic Angiopathies; Female; Humans; Hyperchole | 1996 |
Fluid, ionic and hormonal changes induced by high salt intake in salt-sensitive and salt-resistant hypertensive patients.
Topics: Aldosterone; Atrial Natriuretic Factor; Blood Glucose; Calcium; Cholesterol; Cholesterol, LDL; Creat | 1996 |
High blood pressure of hypertriglyceridaemic rats is related to metabolic disturbances.
Topics: Animals; Blood Pressure; Crosses, Genetic; Female; Hypertension; Hypertriglyceridemia; Kidney; Lipid | 1995 |
Poor predictive value of platelet count, mean platelet volume and serum urate in hypertension in pregnancy.
Topics: Female; Humans; Hypertension; Platelet Count; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; P | 1996 |
Urinary calcium excretion in treated and untreated essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aldosterone; Antihypertensive Agents; Benzothiadiazines; Blood G | 1996 |
Serum angiotensin-converting enzyme activity in patients with endemic nephropathy.
Topics: Adult; Arteries; Balkan Nephropathy; Blood Pressure; Creatinine; Female; Humans; Hypertension; Male; | 1996 |
Parameters associated with adverse perinatal outcome in hypertensive pregnancies.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Disease Progression; Ductus Arteriosus, Patent; Female; | 1996 |
Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects.
Topics: Adult; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; Uric Acid; Xanthine Oxidase | 1996 |
An evaluation of various indices of body weight change and their relationship with coronary risk factors.
Topics: Adult; Blood Pressure; Body Mass Index; Cholesterol; Coronary Disease; Humans; Hyperlipidemias; Hype | 1996 |
Hyperuricemia and pregnancy induced hypertension--reappraisal.
Topics: Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Uri | 1996 |
Maternal serum testing for alpha-fetoprotein and human chorionic gonadotropin in high-risk pregnancies.
Topics: alpha-Fetoproteins; Chorionic Gonadotropin; Female; Fetal Growth Retardation; Gestational Age; Human | 1996 |
Associations between carotid atherosclerosis and high factor VIII activity, dyslipidemia, and hypertension.
Topics: Adult; Age Factors; Aged; Antithrombin III; Arteriosclerosis; Blood Pressure; Carotid Artery Disease | 1997 |
[Diabetes mellitus at the National Hospital Center of Ouagadougou (Burkina Faso)].
Topics: Adult; Burkina Faso; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetes Me | 1996 |
[Influence of energy expenditure and other factors on the incidence of arterial hypertension in employees with some types of employment in Tychy].
Topics: Adolescent; Adult; Age Distribution; Aged; Air Pollution; Alcohol Drinking; Cholesterol; Energy Meta | 1996 |
[Variations in the uric acid levels in pregnancy hypertension].
Topics: Adult; Female; Gestational Age; Humans; Hypertension; Maternal Age; Pregnancy; Pregnancy Complicatio | 1997 |
[Serum levels of uric acid, lipids and glucose in essential hypertension].
Topics: Adult; Blood Glucose; Humans; Hypertension; Lipids; Male; Uric Acid | 1996 |
Acceleration of hypertensive cerebral injury by the inhibition of xanthine-xanthine oxidase system in stroke-prone spontaneously hypertensive rats.
Topics: Allopurinol; Amitrole; Animals; Brain; Catalase; Cerebral Cortex; Cerebrovascular Disorders; Enzyme | 1997 |
Serum uric acid and its correlates in Chinese adult populations, urban and rural, of Beijing. The PRC-USA Collaborative Study in Cardiovascular and Cardiopulmonary Epidemiology.
Topics: Adult; Age Distribution; Body Mass Index; Cardiovascular Diseases; China; Cross-Sectional Studies; D | 1997 |
Relationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients.
Topics: Administration, Oral; Aged; Apolipoproteins; Biguanides; Blood Glucose; Blood Pressure; Body Constit | 1997 |
[Hyperuricemia as a risk factor for noninfectious diseases in the inhabitants of Chuvashia].
Topics: Adolescent; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hyperlipidemias; Hypertension; M | 1997 |
Plasma fibronectin: predictive factor in gestational hypertension?
Topics: Adult; Female; Fibronectins; Humans; Hypertension; Pre-Eclampsia; Predictive Value of Tests; Pregnan | 1997 |
Microalbuminuria and renal haemodynamics in essential hypertension.
Topics: Adult; Aged; Albuminuria; Female; Hemodynamics; Humans; Hypertension; Kidney; Kidney Function Tests; | 1997 |
Relationship of red blood cell ion transport alterations and serum lipid abnormalities in Lyon genetically hypertensive rats.
Topics: Animals; Blood Pressure; Bumetanide; Cell Membrane Permeability; Chlorides; Cholesterol; Erythrocyte | 1997 |
Does insulin resistance unite the separate components of the insulin resistance syndrome? Evidence from the Miami Community Health Study.
Topics: Adult; Anthropometry; Cholesterol, HDL; Cohort Studies; Comorbidity; Coronary Disease; Ethnicity; Fe | 1997 |
Kidney function in cyclosporine-treated pediatric heart transplant recipients.
Topics: Adolescent; Azathioprine; Biopsy; Chelating Agents; Child; Child, Preschool; Chromium Radioisotopes; | 1997 |
[Risk factors and etiology of retinal vein occlusion].
Topics: Adult; Age Factors; Aged; Arteriosclerosis; Behcet Syndrome; Coronary Disease; Diabetes Complication | 1995 |
The effect of chronic L-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Carnitine; Heart Rate; Hypertension; Lipids; Male; Organ Size; | 1998 |
Health risk assessment for diabetes mellitus based on longitudinal analysis of MHTS database.
Topics: Adolescent; Adult; Age Factors; Aged; Alcohol Drinking; Analysis of Variance; Blood Glucose; Body Ma | 1998 |
Which urinary proteins are decreased after angiotensin converting--enzyme inhibition?
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; Body Weight; C | 1998 |
[The relationship between body mass index and coronary risk factors].
Topics: Adult; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Glucose Intoler | 1998 |
The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy.
Topics: Case-Control Studies; Chronic Disease; Diagnosis, Differential; Female; Humans; Hypertension; Pre-Ec | 1998 |
Red blood cell sodium-lithium countertransport and risk of future hypertension: the Olivetti Prospective Heart Study.
Topics: Age Factors; Blood Glucose; Blood Pressure; Cholesterol; Erythrocytes; Follow-Up Studies; Humans; Hy | 1998 |
Calciuria and preeclampsia.
Topics: Calcium; Chronic Disease; Cross-Sectional Studies; Female; Humans; Hypertension; Pre-Eclampsia; Preg | 1998 |
Clustering of cardiovascular risk factors in hyperinsulinemia in Japanese without diabetes.
Topics: Adult; Aged; Cardiovascular Diseases; Cholesterol, LDL; Female; Humans; Hyperinsulinism; Hypertensio | 1998 |
Uric acid as an independent risk factor in the treatment of hypertension.
Topics: Humans; Hypertension; Kidney; Risk Factors; Uric Acid | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Intolerance; Homeos | 1998 |
Urinary N-acetyl-beta-glucosaminidase in the prediction of preeclampsia.
Topics: Acetylglucosaminidase; Adult; Albuminuria; Clinical Enzyme Tests; Creatinine; Female; Humans; Hypert | 1998 |
Is uric acid really an independent cardiovascular risk factor?
Topics: Antihypertensive Agents; Female; Humans; Hypertension; Losartan; Male; Risk Factors; Ticrynafen; Uri | 1998 |
Microalbuminuria and hypertension in nondiabetic Japanese men.
Topics: Adult; Aged; Albuminuria; Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus; Glucose Tole | 1999 |
Prevalence of microalbuminuria and relationship to the risk of cardiovascular disease in the Japanese population.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Albuminuria; Blood Glucose; Blood Proteins; Chi-Square | 1999 |
Severe protracted lichenoid eruption and hyperuricemia following administration of alacepril.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Diabetes Mellitus, Type 2; Female; Follow | 1999 |
Serum uric acid: correlation with biological, clinical and behavioral factors in Japanese men.
Topics: Adult; Alcohol Drinking; Cross-Sectional Studies; Diabetes Mellitus; Gout; Humans; Hypertension; Lif | 1999 |
The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification.
Topics: Aspartate Aminotransferases; Birth Weight; Cesarean Section; Eclampsia; Female; Fetal Death; Headach | 1999 |
[The role of insulin resistance in the clustering of cardiovascular risk factors].
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; China; Cluster Analysis; Coronary Disease; Female; Hu | 1997 |
Serum leptin is associated with serum uric acid concentrations in humans.
Topics: Adipose Tissue; Analysis of Variance; Body Constitution; Body Mass Index; Case-Control Studies; Cros | 1999 |
Serum uric acid and cardiovascular events in successfully treated hypertensive patients.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Cardiovascular Diseases; Cohort Studies; Di | 1999 |
Clinical, anthropometric, metabolic and insulin profile of men with fast annual growth rates of benign prostatic hyperplasia.
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Arteriosclerosis; Blood Pressure; Body Height; Body M | 1999 |
Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia.
Topics: Adult; Aged; Antihypertensive Agents; Blood Chemical Analysis; Female; Fenofibrate; Humans; Hyperten | 1999 |
Uric acid as a cardiovascular risk factor in arterial hypertension.
Topics: Humans; Hypertension; Risk Factors; Uric Acid | 1999 |
[Urate affection of kidneys and metabolic disturbances in hypertensive patients].
Topics: Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Humans; | 1999 |
Differential effects of T- and L-type calcium antagonists on glomerular dynamics in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Benzimidazoles; Calcium Channel Blockers; Calcium Chan | 1999 |
Does a predisposition to the metabolic syndrome sensitize women to develop pre-eclampsia?
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Blood Pressure; Body Mass Index; Causality; Creatinine; Endothe | 1999 |
Metabolic syndrome is associated with changes in D-mannose metabolism.
Topics: Aged; Blood Glucose; Body Mass Index; Cholesterol; Diabetes Mellitus, Type 2; Female; Glucose Intole | 1999 |
Hypertension aggregates in families of kidney stone patients with high urinary excretion of uric acid.
Topics: Adult; Female; Humans; Hypertension; Kidney Calculi; Male; Medical Records; Middle Aged; Odds Ratio; | 1999 |
[Effects of Ramadan fasting on the health of Muslims].
Topics: Cholesterol; Dehydration; Fasting; Humans; Hypertension; Islam; Life Style; Uric Acid; Weight Loss | 2000 |
Hyperuricaemia in Type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Body Mass Index; Coronary Disease; Creatinine; Cross-Sectional Studies; Diabete | 1999 |
Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety).
Topics: Adult; Analysis of Variance; Arteriosclerosis; Blood Glucose; Cholesterol; Cholesterol, HDL; Diabete | 2000 |
The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study.
Topics: Adult; Alcohol Drinking; Diuretics; Follow-Up Studies; Gout; Humans; Hypertension; Incidence; Logist | 2000 |
[Prevalence of dyslipidemia and its phenotypes in recently diagnosed essential arterial hypertension].
Topics: Adult; Alcohol Drinking; Algorithms; Blood Glucose; Cardiovascular Diseases; Female; Humans; Hyperli | 2000 |
The clinical utility of serum uric acid measurements in pre-eclampsia and transient hypertension in pregnancy.
Topics: Biomarkers; Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Uric Ac | 2000 |
[Tophaceous gout].
Topics: Aged; Aged, 80 and over; Diuretics; Female; Fingers; Gout; Humans; Hypertension; Uric Acid | 2000 |
Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study.
Topics: Antihypertensive Agents; Biomarkers; Cardiovascular Diseases; Female; Humans; Hypertension; Male; Mi | 2000 |
Plasma purine turnover metabolites in women with normal pregnancy and pregnancy complicated with induced hypertension as compared to fetal well-being indices.
Topics: Adult; Apgar Score; Blood Pressure; Diastole; Female; Gestational Age; Heart Rate, Fetal; Humans; Hy | 2000 |
[Efficacy, tolerability and safety of cyclosporine for microemulsion in the treatment of active rheumatoid arthritis. Open study].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Cyclosporine; Emul | 2000 |
Management of hypertension and dyslipidaemia in patients presenting with hyperuricaemia: case histories.
Topics: Antihypertensive Agents; Arteriosclerosis; Benzothiadiazines; Diuretics; Female; Fenofibrate; Humans | 2000 |
Tissue kallikrein activity in pregnancy.
Topics: Adult; Analysis of Variance; Black People; Case-Control Studies; Creatinine; Female; Humans; Hyperte | 2000 |
[Twin pregnancy and preeclampsia].
Topics: Adult; Biomarkers; Comorbidity; Edema; Female; Gravidity; Humans; Hypertension; Incidence; Parity; P | 2000 |
Relationship of residual beta-cell function, metabolic control and chronic complications in type 2 diabetes mellitus.
Topics: Aged; Albuminuria; Body Mass Index; C-Reactive Protein; Cholesterol, HDL; Cohort Studies; Diabetes M | 2000 |
Hyperinsulinemia and insulin resistance related metabolic syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Humans; Hyperglycemia; | 2001 |
The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers.
Topics: Adrenergic alpha-Antagonists; Aged; AMP Deaminase; Angiotensin-Converting Enzyme Inhibitors; Antihyp | 2001 |
[Changes in cardiovascular risk factors after renal transplantation].
Topics: Adult; Blood Pressure; Body Composition; Body Mass Index; Cardiovascular Diseases; Creatinine; Cysta | 2001 |
Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men.
Topics: Adult; Alcohol Drinking; Blood Pressure; Body Mass Index; Cholesterol; Glycated Hemoglobin; Humans; | 2001 |
Hypophosphataemia: cause of the disturbed metabolism in the metabolic syndrome.
Topics: Blood Glucose; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, | 2001 |
Urate and arteriosclerosis in primary hyperparathyroidism.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Blood Glucose; Diabetes Complications; Female; Glo | 2001 |
Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey.
Topics: Adult; Alcohol Drinking; Asian People; Body Mass Index; Cohort Studies; Diabetes Mellitus, Type 2; H | 2001 |
[Relationship between severity of essential arterial hypertension and the prevalence hyperuricemia].
Topics: Adult; Blood Pressure; Cohort Studies; Female; Humans; Hypertension; Male; Middle Aged; Multivariate | 2001 |
[Hyperuricemia as a cardiovascular risk factor].
Topics: Biomarkers; Cardiovascular Diseases; Humans; Hypertension; Risk Factors; Uric Acid | 2001 |
[Relationship between mass of the left ventricular myocardium and uric acid metabolic imbalance in patients with arterial hypertension].
Topics: Adult; Albuminuria; Body Mass Index; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Ki | 2001 |
Three years of experience with bisoprolol in the treatment of mild to moderate hypertension.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Bisoprolol; Blood Glucose; Blood Pressure; Cho | 1990 |
Hypertension and its relation to renal function 10 years after pregnancy complicated by pre-eclampsia and pregnancy induced hypertension.
Topics: Adult; Blood Urea Nitrogen; Body Weight; Calcium; Case-Control Studies; Chronic Disease; Creatinine; | 2000 |
Hemodynamic and metabolic profile in offspring of malignant hypertensive parents.
Topics: Adolescent; Adult; Aldosterone; Blood Glucose; Blood Pressure; Cholesterol; Diastole; Family Health; | 2001 |
Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
Topics: Age of Onset; Alcohol Drinking; Body Mass Index; Comorbidity; Creatinine; Cross-Sectional Studies; D | 2001 |
Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes.
Topics: Albumins; Allopurinol; Animals; Bilirubin; Blood Pressure; Fasting; Female; Heme; Hypertension; Hypo | 2001 |
Educational level and hypertension: how socioeconomic differences condition health care.
Topics: Adult; Aged; Cholesterol; Delivery of Health Care; Echocardiography; Educational Status; Female; Fib | 2001 |
Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study.
Topics: Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol; Female; Hawaii; Humans; Hyperinsulinism | 2001 |
Microalbuminuria, central adiposity and hypertension in the non-diabetic urban population of the MONICA Augsburg survey 1994/95.
Topics: Adult; Age Factors; Aged; Albuminuria; Body Constitution; Cholesterol; Cholesterol, HDL; Diabetes Co | 2001 |
Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant.
Topics: Adult; Aged; Amino Acid Substitution; Blood Pressure; Creatinine; Glomerular Filtration Rate; Humans | 2001 |
Effects of losartan/diuretic combination treatment on serum uric acid levels in hypertensive patients.
Topics: Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hyperten | 2001 |
Serum uric acid levels and microalbuminuria in mild hypertensive patients.
Topics: Albuminuria; Female; Humans; Hypertension; Male; Middle Aged; Uric Acid | 2000 |
High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension.
Topics: Adult; Calcium; Female; Humans; Hypertension; Kidney Calculi; Male; Medical Records; Middle Aged; Ph | 2002 |
Comparative effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricemia and gout.
Topics: Antihypertensive Agents; Biphenyl Compounds; Gout; Humans; Hypertension; Irbesartan; Losartan; Tetra | 2002 |
[Clinical implication of the body mass and waist/thigh indices in hypertensive patients: correlations with blood uric acid levels].
Topics: Anthropometry; Body Mass Index; Cholesterol; Female; Humans; Hypertension; Male; Middle Aged; Obesit | 2002 |
[Evaluation of glucose, insulin, C-peptide uric acid serum levels in patients with psoriasis].
Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Case-Control Studies; Diabetes Mellitus; Humans; H | 2001 |
Maternal serum uric acid as predictor of fetal acidemia.
Topics: Female; Fetal Diseases; Humans; Hypertension; Linear Models; Placental Circulation; Predictive Value | 2002 |
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Con | 2002 |
The effects of the addition of micronised fenofibrate on uric acid metabolism in patients receiving indapamide.
Topics: Adult; Aged; Antihypertensive Agents; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Drug Therapy | 2002 |
Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia.
Topics: Adult; Altitude; Case-Control Studies; Hematocrit; Humans; Hypertension; Male; Oxygen; Polycythemia; | 2002 |
Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia.
Topics: Adult; Altitude; Case-Control Studies; Hematocrit; Humans; Hypertension; Male; Oxygen; Polycythemia; | 2002 |
Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia.
Topics: Adult; Altitude; Case-Control Studies; Hematocrit; Humans; Hypertension; Male; Oxygen; Polycythemia; | 2002 |
Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia.
Topics: Adult; Altitude; Case-Control Studies; Hematocrit; Humans; Hypertension; Male; Oxygen; Polycythemia; | 2002 |
Evaluation of indices of alcohol intake in a population of 60-year-old men in Uppsala, Sweden.
Topics: Alcohol Drinking; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Electrocardiography; E | 1979 |
[Metabolic effects of a fixed combination (betablocker plus saluretic) in long-term treatment of arterial hypertension (author's transl)].
Topics: Adult; Blood Glucose; Blood Pressure; Cholesterol; Drug Combinations; Female; Humans; Hydrochlorothi | 1979 |
Elevated serum uric acid levels during treatment with antihypertensive drugs.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Benzothiadiazines; Diuretics; Female; Humans; Hypertension | 1979 |
Diuretics as initial treatment for essential hypertension.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Humans; Hyperg | 1979 |
Clinical relevance of coagulation and renal changes in pre-eclampsia.
Topics: Adult; Blood Cell Count; Blood Coagulation; Blood Platelets; Creatinine; Factor VIII; Female; Fibrin | 1978 |
Expensive new drugs and the costs of avoiding a small risk.
Topics: Benzothiadiazines; Cost-Benefit Analysis; Diuretics; Glycolates; Humans; Hypertension; Risk; Sodium | 1979 |
Serum uric acid values in hypertension.
Topics: Adult; Aged; Cholesterol; Humans; Hypertension; Male; Middle Aged; Uric Acid | 1979 |
[Gout in young subjects].
Topics: Adolescent; Adult; Age Factors; Angina Pectoris; Back Pain; Diabetes Complications; Fatty Liver; Fem | 1977 |
[Frequency and distribution of types of hyperlipoproteinemia with life-shortening risk factors among ambulant patients (author's transl)].
Topics: Cholesterol; Diabetes Complications; Female; Germany, West; Gout; Humans; Hyperlipidemias; Hypertens | 1975 |
[Uric acid content in coronary atherosclerosis and hypertensive disease].
Topics: Adult; Arteriosclerosis; Female; Humans; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Myocard | 1976 |
CHD risk factors in the elderly.
Topics: Age Factors; Aged; Cardiomegaly; Coronary Disease; Diabetes Complications; Female; Humans; Hypertens | 1976 |
Primary type V hyperlipoproteinemia. A descriptive study in 32 families.
Topics: Adult; Carbohydrate Metabolism, Inborn Errors; Cholesterol; Chylomicrons; Coronary Disease; Female; | 1977 |
[Type V hyperlipemia. 54 cases (author's transl)].
Topics: Adolescent; Adult; Aged; Alcoholism; Blood Protein Electrophoresis; Child; Child, Preschool; Cholest | 1979 |
[Frequency of cardiovascular risk factors in renal transplant patients (author's transl)].
Topics: Adolescent; Adult; Cardiovascular Diseases; Cholesterol; Diabetes Complications; Female; Humans; Hyp | 1978 |
[Important prognostic factors for the results of physiotherapeutic exercises in intermittent claudication (author's transl)].
Topics: Aged; Coronary Disease; Diabetes Complications; Exercise Therapy; Female; Humans; Hypercholesterolem | 1977 |
[Diabetes mellitus and coronary disease--common problems in long-term care].
Topics: Adult; Coronary Disease; Diabetes Complications; Female; Humans; Hyperlipidemias; Hypertension; Male | 1979 |
Hyperuricaemia in hypertension: role of alcohol.
Topics: Adult; Alcohol Drinking; Humans; Hypertension; Male; Middle Aged; Uric Acid | 1979 |
[Methods for the early recognition of gestosis].
Topics: Angiotensin II; Embryo Implantation; Female; Humans; Hypertension; Methods; Pre-Eclampsia; Pregnancy | 1979 |
Office management of chronic renal disease.
Topics: Animals; Calcium; Chronic Disease; Counseling; Dietary Proteins; Dogs; Humans; Hyperkalemia; Hyperte | 1979 |
[Coronary risk factors and extent of angiographically proven coronary artery stenoses (author's transl)].
Topics: Angina Pectoris; Arteries; Arteriosclerosis; Constriction, Pathologic; Coronary Angiography; Coronar | 1979 |
Elevated serum uric acid. A cardiovascular risk factor?
Topics: Adolescent; Cardiovascular Diseases; Coronary Disease; Diuretics; Female; Humans; Hypertension; Male | 1979 |
[The prognostic value of raised uric acid in the blood in arterial hypertension in pregnancy. 58 cases (author's transl)].
Topics: Adult; Female; Humans; Hypertension; Hypertension, Renovascular; Pre-Eclampsia; Pregnancy; Pregnancy | 1979 |
[The cardiovascular risk profile of the borderline diabetic].
Topics: Adult; Aged; Cardiovascular Diseases; Coronary Disease; Diabetes Complications; Humans; Hypercholest | 1979 |
Acute arthralgia (gout?) after tricrynafen.
Topics: Glycolates; Gout; Humans; Hypertension; Joint Diseases; Male; Middle Aged; Pain; Ticrynafen; Uric Ac | 1979 |
Ticrynafen: a new thiazide-like but uricosuric antihypertensive diuretic.
Topics: Aldosterone; Animals; Glomerular Filtration Rate; Glycolates; Hemodynamics; Humans; Hypertension; Ki | 1979 |
Hypertension:risk factors and recent advances in treatment with tienilic acid. Proceedings of a symposium held at the Royal College of Physicians, London, on 22 and 23 May 1978.
Topics: Glycolates; Humans; Hypertension; Kidney; Risk; Ticrynafen; Uric Acid | 1979 |
Tienilic acid--summary.
Topics: Glycolates; Humans; Hypertension; Kidney; Ticrynafen; Uric Acid | 1979 |
Hypertension, renal function and gout.
Topics: Adult; Glomerular Filtration Rate; Gout; Humans; Hypertension; Kidney; Kidney Diseases; Middle Aged; | 1979 |
Tienilic acid in hypertension with hyperuricaemia.
Topics: Allopurinol; Bendroflumethiazide; Creatinine; Female; Glycolates; Gout; Humans; Hypertension; Male; | 1979 |
The effect of thiazide diuretics on coronary risk factors.
Topics: Aged; Benzothiadiazines; Blood Glucose; Coronary Disease; Diuretics; Female; Hematocrit; Humans; Hyp | 1979 |
Antihypertensive and renal effects of tienilic acid.
Topics: Glycolates; Humans; Hydrochlorothiazide; Hypertension; Kidney; Male; Potassium; Ticrynafen; Uric Aci | 1979 |
Evaluation of a new uricosuric diuretic--ticrynafen.
Topics: Diuretics; Drug Evaluation; Glycolates; Gout; Heart Failure; Humans; Hypertension; Ticrynafen; Uric | 1979 |
[Coronary risk factors].
Topics: Coronary Disease; Diabetes Complications; Diet; Female; Humans; Hypercholesterolemia; Hyperlipoprote | 1979 |
Adipose tissue cellularity--metabolic aspects. The population study of women in Göteborg 1974-1975.
Topics: Adipose Tissue; Adult; Aged; Anthropometry; Blood Glucose; Body Composition; Cell Count; Coronary Di | 1979 |
A fixed combination of metoprolol and hydrochlorothiazide for hypertension: a multi-centre study.
Topics: Adult; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; M | 1979 |
[Short-term and median-term effects of tienilic acid in hypertension].
Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female; Glycolates; Humans; Hypertension; M | 1979 |
[Hemodynamic observations in a group of hypertensive patients treated with tienilic acid (author's transl)].
Topics: Adult; Female; Glycolates; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Potassium; Ticryna | 1979 |
[Arterial hypertension and pregnancy: obstetric management].
Topics: Female; Hospitalization; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; P | 1979 |
[Arterial pressure of aged persons in urban environment].
Topics: Age Factors; Animals; Chick Embryo; Female; Homes for the Aged; Humans; Hypertension; Male; Occupati | 1978 |
[Modern differential-therapeutic aspects of the drug therapy of chronic gout].
Topics: Allopurinol; Arteriosclerosis; Citrates; Gout; Humans; Hypertension; Kidney Diseases; Obesity; Pheny | 1979 |
[Uric acid content in hypertension complicated by obesity].
Topics: Adult; Female; Humans; Hypertension; Male; Middle Aged; Obesity; Uric Acid | 1977 |
Cardiovascular risk factors in gross obesity.
Topics: Adult; Age Factors; Blood Glucose; Cardiovascular Diseases; Cholesterol; Female; Follow-Up Studies; | 1977 |
[Pathomorphology of the heart in angina pectoris].
Topics: Adult; Aged; Angina Pectoris; Coronary Vessels; Death, Sudden; Diabetes Complications; Female; Human | 1978 |
Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study.
Topics: Adult; Blood Pressure; Body Weight; Cholesterol; Drug Therapy, Combination; Humans; Hydrochlorothiaz | 1978 |
[Action of tienilic acid, a diuretic modifying the tubular system of the excretion of organic acids (author's transl)].
Topics: Adult; Diuretics; Drug Evaluation; Female; Glycolates; Humans; Hypertension; Male; Middle Aged; Peni | 1978 |
Overweight in women--metabolic aspects. The population study of women in Göteborg 1968--1969.
Topics: Adult; Alcohol Drinking; Blood Glucose; Blood Pressure; Body Composition; Body Height; Body Weight; | 1978 |
The workinghman's diet. II. Effect of weight reduction in obese patients with hypertension, diabetes, hyperuricemia and hyperlipidemia.
Topics: Body Weight; Diet, Diabetic; Diet, Reducing; Evaluation Studies as Topic; Female; Follow-Up Studies; | 1978 |
Intermittent claudication: prevalence and risk factors.
Topics: Aged; Female; Fibrinogen; Humans; Hypertension; Intermittent Claudication; Male; Middle Aged; Risk; | 1978 |
[Obesity and cardiovascular risk].
Topics: Adult; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus; Female; Humans; Hyperlipidemias; Hyp | 1978 |
Diuretics in the treatment of hypertension.
Topics: Benzothiadiazines; Diuretics; Humans; Hyperglycemia; Hypertension; Hypokalemia; Sodium Chloride Symp | 1978 |
Serum uric acid and the renin-angiotensin system in hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin II; Child; Creatinine; Extracellular Space; Female; Furosemide; | 1978 |
Blood plasma constituents in 14-week old hypertensive and hypotensive strains of turkeys.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Glucose; Blood Proteins; Cholester | 1978 |
[Acute kidney failure during the administration of an hypouricemic diuretic, tienilic acid].
Topics: Acute Kidney Injury; Diuretics; Glycolates; Humans; Hypertension; Male; Middle Aged; Phenoxyacetates | 1978 |
Use of diuretics in treatment of hypertension secondary to renal disease.
Topics: Adult; Aldosterone; Antihypertensive Agents; Creatinine; Female; Furosemide; Humans; Hydrochlorothia | 1978 |
Hyperuricemia associated with hypertension. A 4-year follow-up study of hyperuricemic hypertensives.
Topics: Adolescent; Adult; Aged; Benzothiadiazines; Blood Pressure; Cerebrovascular Disorders; Diuretics; Fe | 1978 |
Biochemical consequences of diuretic therapy in hypertension.
Topics: Benzothiadiazines; Diuretics; Humans; Hypercalcemia; Hyperglycemia; Hypertension; Hypokalemia; Sodiu | 1978 |
Uric acid, diuretics and the kidney.
Topics: Benzothiadiazines; Diuretics; Female; Humans; Hypertension; Kidney; Male; Sodium Chloride Symporter | 1978 |
[Retinal thromboses with metabolic disturbances (author's transl)].
Topics: Adult; Age Factors; Aged; Female; Glucose; Humans; Hyperglycemia; Hyperlipidemias; Hypertension; Lip | 1978 |
[Comparison of spironolactone and amiloride combined with hydrochlorothiazide in the treatment of slight or moderate hypertension].
Topics: Amiloride; Blood Glucose; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothi | 1978 |
[Thienylic acid, a new drug with saluretic and uricosuric activity. Preliminary data].
Topics: Adult; Aged; Diuretics; Drug Evaluation; Female; Glycolates; Humans; Hypertension; Male; Middle Aged | 1978 |
Diabetes and its vascular complications in Malaysia.
Topics: Adult; Aged; Blood Glucose; Cerebrovascular Disorders; Cholesterol; Coronary Disease; Diabetes Melli | 1978 |
[Myocardial infarction: comparative study of principal risk factors in the two sexes].
Topics: Adult; Age Factors; Aged; Blood Glucose; Female; France; Humans; Hyperlipidemias; Hypertension; Lipi | 1976 |
[Hyperuricemia in Parkinson's syndrome--by chance or probable?].
Topics: Adult; Aged; Female; Gout; Humans; Hypertension; Levodopa; Male; Middle Aged; Obesity; Parkinson Dis | 1976 |
[Occurrence of hyperuricemia in atrioventricular block. (Results of a study of 158 patients with isotopic pacemaker implantations)].
Topics: Adolescent; Adult; Age Factors; Cardiac Surgical Procedures; Child; Female; Gout; Heart Block; Human | 1976 |
Some unusual features of gouty arthritis in females.
Topics: Adult; Age Factors; Aged; Black or African American; Female; Gout; Humans; Hypertension; Kidney Calc | 1977 |
Epidemiology of serum uric acid among 8000 Japanese-American men in Hawaii.
Topics: Aged; Alcohol Drinking; Coronary Disease; Diabetes Mellitus; Hawaii; Humans; Hypertension; Japan; Ma | 1977 |
Diuretic-induced hyperuricemia: a possible solution.
Topics: Diuretics; Hypertension; Phenoxyacetates; Uric Acid | 1977 |
Nutritional state and purine metabolism.
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Body Weight; Coronary Disease; Diabetes Complications; D | 1977 |
Panel discussion: hyperuricemia as a risk factor.
Topics: Alcohol Drinking; Allopurinol; Blood Proteins; Body Weight; Coronary Disease; Diabetes Complications | 1977 |
Gout disease. Its natural history based on 1,000 observations.
Topics: Calculi; Diabetes Complications; Female; Gout; Humans; Hypertension; Male; Sex Factors; Uric Acid | 1977 |
[The "alcohol-syndrome" from internal medical view (author's transl)].
Topics: Adult; Age Factors; Alcoholism; Anxiety; Fatty Liver; Humans; Hyperlipidemias; Hypertension; Obesity | 1977 |
Studies covering combined treatments with xipamide. Results of a long-term antihypertensive treatment.
Topics: Adult; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Chlorides; Clonidine; Diuretics; Drug The | 1977 |
Fructose-induced hyperuricemia in essential hypertension.
Topics: Adult; Female; Fructose; Humans; Hypertension; Male; Middle Aged; Purine Nucleotides; Uric Acid | 1977 |
[Frequency and distribution of risk factors in hearing loss].
Topics: Adolescent; Adult; Aged; Deafness; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; | 1977 |
[Gouty attacks in hyperuricemic hypertensives. A follow-up study (author's transl)].
Topics: Adolescent; Adult; Aged; Female; Follow-Up Studies; Gout; Humans; Hypertension; Male; Middle Aged; U | 1977 |
[Myocardial infarct in men under 40 years of age].
Topics: Adult; Age Factors; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Myocardial Infarc | 1977 |
Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis.
Topics: Animals; Arteriosclerosis; Female; Hyperglycemia; Hyperlipidemias; Hypertension; Male; Oxonic Acid; | 1977 |
[Health maintenance despite health risks. III. 3 civilization diseases: hypertension, diabetes, and gout].
Topics: Adolescent; Adult; Aged; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus; Female; Gout | 1976 |
Hyperuricemia in pre-eclampsia. A reappraisal.
Topics: Absorption; Chronic Disease; Creatinine; Extracellular Space; Female; Glomerular Filtration Rate; Hu | 1976 |
Effects of furosemide and chlorothiazide on blood pressure and plasma renin activity.
Topics: Adult; Aged; Blood Pressure; Chlorothiazide; Female; Furosemide; Humans; Hypertension; Male; Middle | 1976 |
Ischaemic disease in men and women with familial hypercholesterolaemia and xanthomatosis. A comparative study of genetic and environmental factors in 274 heterozygous cases.
Topics: Adult; Cholesterol; Coronary Disease; Female; Heterozygote; Humans; Hypercholesterolemia; Hypertensi | 1976 |
[Etiology of retinal venous thromboses].
Topics: Adult; Arteriosclerosis; Diabetic Retinopathy; Female; Humans; Hypertension; Retinal Vein; Thrombosi | 1976 |
[Serum levels of uric acid in patients from general practices (author's transl)].
Topics: Age Factors; Cholesterol; Family Practice; Female; Humans; Hypertension; Male; Obesity; Rheumatoid F | 1976 |
Hypertension in pregnancy: normal and abnormal renal function.
Topics: Blood Urea Nitrogen; Creatinine; Female; Humans; Hypertension; Hypertension, Renal; Kidney; Pregnanc | 1975 |
Abnormal renal urate homeostasis in systemic disorders.
Topics: Alcoholism; Diabetes Mellitus; Female; Fructose Intolerance; Glomerular Filtration Rate; Glycogen St | 1975 |
Coronary risk factors in New Zealand Maori and European adolescents: The Rotoua Lakes Study 2.
Topics: Adolescent; Body Height; Body Weight; Coronary Disease; Ethnicity; Female; Humans; Hypercholesterole | 1975 |
Systolic hypertension, hyperuricemia, and hyperglycemia as risk factors in cardiovascular disease.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Humans; Hyperglycemia; | 1976 |
Effects of diuretics on lipid metabolism in patients with essential hypertension.
Topics: Adult; Blood Glucose; Cholesterol; Humans; Hydrochlorothiazide; Hypercholesterolemia; Hypertension; | 1976 |
Antihypertensive drug therapy in USAF flying personnel.
Topics: Adult; Aerospace Medicine; Antihypertensive Agents; Electrocardiography; Gastrointestinal Hemorrhage | 1975 |
[Clinical study of LC 75 (Ampliuril pH) in the states of hyperuricemia].
Topics: Benzofurans; Carbonates; Coronary Disease; Diabetes Complications; Gout; Humans; Hypertension; Kidne | 1975 |
Prolactin in hypertensive pregnancy.
Topics: Edema; Female; Humans; Hypertension; Methyldopa; Pre-Eclampsia; Pregnancy; Pregnancy Complications, | 1975 |
Gouty arthritis in the black race.
Topics: Adult; Aged; Anemia, Sickle Cell; Arthritis; Benzothiadiazines; Black People; Colchicine; Diuretics; | 1975 |
Hyperuricaemia--to treat or not?
Topics: Alcohol Drinking; Diet; Endocrine System Diseases; Gout; Hematologic Diseases; Humans; Hyperlipidemi | 1975 |
[Factors of coronary risk in men and women].
Topics: Adult; Age Factors; Blood Glucose; Coronary Disease; Female; Follow-Up Studies; Humans; Hypertension | 1975 |
Myocardial infarction in young men. Study of risk factors in nine countries.
Topics: Adult; Australia; Body Weight; Cholesterol; Coronary Disease; Diabetes Complications; Germany, West; | 1975 |
Long survival in sickle cell anemia.
Topics: Age Factors; Aged; Anemia, Aplastic; Anemia, Sickle Cell; Chronic Disease; Electrophoresis, Starch G | 1975 |
Sodium restriction and thiazide diuretics in the treatment of hypertension.
Topics: Amiloride; Bicarbonates; Body Weight; Chlorothiazide; Diet, Sodium-Restricted; Diuretics; Humans; Hy | 1975 |
A 3-year follow-up of middle-aged men with borderline blood pressure.
Topics: Blood Pressure; Cholesterol; Creatinine; Follow-Up Studies; Heart Rate; Humans; Hypertension; Male; | 1975 |
[Cerebral infarctions. Study of their prevention].
Topics: Adult; Aged; Atrial Fibrillation; Contraceptive Agents; Diabetes Complications; Female; Heart Diseas | 1975 |
[Clinical significance of hyperuricaemia in medically-hospitalized women over 50 years of age (author's transl)].
Topics: Age Factors; Allopurinol; Diuretics; Female; Humans; Hypertension; Lung Diseases; Middle Aged; Uric | 1975 |
[Latent diabetes mellitus as a risk factor in myocardial infarct].
Topics: Adult; Aged; Diabetes Complications; Humans; Hypercholesterolemia; Hypertension; Middle Aged; Myocar | 1975 |
Hypertension in relation to musculoskeletal disorders.
Topics: Blood Pressure; Cholesterol; Female; Humans; Hypertension; Intervertebral Disc; Knee Joint; Male; Ne | 1975 |
Serum uric acid in hypertensive patients.
Topics: Adult; Age Factors; Aged; Benzothiadiazines; Blood Pressure; Diuretics; Female; Humans; Hypertension | 1975 |
[Correlation between purine metabolism disorder and hypertension].
Topics: Female; Fructose; Humans; Hypertension; Male; Metabolic Diseases; Middle Aged; Purines; Uric Acid | 1975 |
[Degenerative joint diseases and hypertension (significance of testing hyperuricemia and rheumatoid factor)].
Topics: Adult; Aged; Coronary Disease; Female; Humans; Hypertension; Male; Middle Aged; Osteoarthritis; Rheu | 1976 |
[Which uric acid value is in need of treatment?].
Topics: Allopurinol; Benzbromarone; Citrates; Coronary Disease; Gout; Humans; Hyperlipidemias; Hypertension; | 1976 |
Detection and characterization of middle-aged men with hypertension.
Topics: Anthropometry; Blood Pressure Determination; Glucose Tolerance Test; Humans; Hypertension; Insulin; | 1976 |
Alpha-methyldopa interference with the phosphotungstate uric acid test.
Topics: Adult; Aged; Chemical Phenomena; Chemistry; Female; Humans; Hypertension; Male; Methods; Methyldopa; | 1976 |
Community-based survey on blood pressure, blood biochemistry and dietary habits in Pu-Li, Taiwan.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure; Diabetes Mellitus; Feeding Behavior; Female; H | 1992 |
Comparison of withdrawing antihypertensive therapy between diuretics and angiotensin converting enzyme inhibitors in essential hypertensives.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Diuretics; Drug Therapy, Combinati | 1992 |
[Influence of parathyroidectomy on the clinical course of primary hyperparathyroidism].
Topics: Calcium; Chondrocalcinosis; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Hyperparat | 1992 |
Serial measurements of platelet angiotensin II binding in two patients with hypertension in pregnancy: case reports.
Topics: Adult; Angiotensin II; Blood Platelets; Creatinine; Female; Humans; Hypertension; Platelet Count; Pr | 1992 |
[The treatment of hypertension with hyperuricemia].
Topics: Antihypertensive Agents; Diet, Reducing; Female; Humans; Hypertension; Male; Risk Factors; Uric Acid | 1992 |
Renal function and blood pressure in patients receiving long-term, low-dose cyclosporine therapy for idiopathic autoimmune uveitis.
Topics: Adult; Autoimmune Diseases; Cholesterol; Creatinine; Cyclosporine; Drug Administration Schedule; Fem | 1992 |
[Study on uric acid metabolism in patients with primary aldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Female; Humans; Hyperaldosteron | 1992 |
Importance of diurnal variations on clinical value and interpretation of serum urate measurements.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Circadian Rhythm; Diabetes Mellitus; Female; Humans; Hyp | 1992 |
[Kidney diseases associated with pregnancy toxemia].
Topics: Blood Coagulation Disorders; Female; Humans; Hypertension; Kidney; Kidney Diseases; Pre-Eclampsia; P | 1992 |
[Metabolic changes in the patient with essential hypertension].
Topics: Analysis of Variance; Blood Glucose; Cholesterol; Female; Hemodynamics; Humans; Hypertension; Male; | 1992 |
Mechanisms of cyclosporine-induced hypertension.
Topics: Absorption; Antiporters; Carrier Proteins; Cyclosporine; Erythrocytes; Humans; Hypertension; Immunos | 1991 |
One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults.
Topics: Adult; Alanine Transaminase; Anti-Bacterial Agents; Aspartate Aminotransferases; Bilirubin; Blood Ur | 1991 |
Evaluation of renal handling of uric acid in essential hypertension: hyperuricemia related to decreased urate secretion.
Topics: Female; Humans; Hypertension; Kidney; Kidney Tubules; Male; Middle Aged; Uric Acid | 1991 |
[The role of the renal dopaminergic and the prostaglandin systems in renal uric acid metabolism in patients with essential hypertension].
Topics: Adult; Aged; Creatinine; Dopamine; Dopamine Antagonists; Female; Humans; Hypertension; Indomethacin; | 1991 |
[Uric acid and arterial hypertension. I. Relation between serum uric acid level and its renal excretion in primary arterial hypertension].
Topics: Adult; Diuresis; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Reference Values; Uric Aci | 1991 |
[Uric acid and arterial hypertension. II. Evaluation of uric acid transport in the nephrons in primary arterial hypertension].
Topics: Adult; Benzbromarone; Biological Transport; Female; Glomerular Filtration Rate; Humans; Hypertension | 1991 |
[Uric acid and arterial hypertension. III. Effect of nifedipine on serum uric acid level and its renal excretion in primary arterial hypertension].
Topics: Adult; Diuresis; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Nifedipine; Time Factors; | 1991 |
[The role of hyperinsulinemia on the renal mechanism of hyperuricemia in overweight patients with essential hypertension].
Topics: Female; Humans; Hypertension; Insulin; Kidney; Male; Middle Aged; Natriuresis; Obesity; Uric Acid | 1991 |
Plasma concentrations of atrial natriuretic factor and hemodynamics in pregnancy-induced hypertension.
Topics: Adult; Atrial Natriuretic Factor; Female; Hemodynamics; Humans; Hypertension; Natriuresis; Pregnancy | 1991 |
[Uric acid and arterial hypertension. IV. Relation between serum uric acid level, the extent of vascular changes and heart enlargement in primary arterial hypertension].
Topics: Adult; Blood Pressure; Cardiomegaly; Female; Humans; Hypertension; Male; Middle Aged; Myocardium; Ur | 1991 |
Does an adequate control of blood pressure protect the kidney in essential hypertension?
Topics: Adrenergic beta-Antagonists; Adult; Diuretics; Female; Follow-Up Studies; Glomerular Filtration Rate | 1990 |
Nephrotoxicity of allopurinol is enhanced in experimental hypertension.
Topics: Allopurinol; Anemia; Animals; Drinking; Hypertension; Kidney; Male; Osmolar Concentration; Rats; Rat | 1991 |
Female gout. Clinical spectrum and uric acid metabolism.
Topics: Adult; Age Factors; Diuretics; Female; Gout; Humans; Hypertension; Kidney Failure, Chronic; Male; Me | 1991 |
Re: "Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries".
Topics: Cholesterol; Heart Rate; Humans; Hypertension; Uric Acid | 1991 |
Changes of blood pressure and lipid pattern during a physical training course in hypertensive subjects.
Topics: Blood Pressure; Body Mass Index; Exercise; Female; Follow-Up Studies; Humans; Hypertension; Lipids; | 1991 |
The relationship between autoantibodies and intrauterine growth retardation in hypertensive disorders of pregnancy.
Topics: Adult; Autoantibodies; Blood Pressure; Creatinine; DNA; Female; Fetal Growth Retardation; Gestationa | 1991 |
Influence of hypertension and dietary copper on indexes of copper status in rats.
Topics: Animals; Biomarkers; Blood Pressure; Ceruloplasmin; Cholesterol; Copper; Eating; Erythrocytes; Healt | 1991 |
Predictors of an increased risk of future hypertension in Utah. A screening analysis.
Topics: Adult; Blood Pressure; Body Mass Index; Female; Forecasting; Humans; Hypertension; Male; Middle Aged | 1991 |
Effects of slow-release nifedipine on water-sodium, uric acid, and calcium metabolism, and on aldosterone secretion in patients with essential hypertension.
Topics: Aldosterone; Angiotensin II; Calcium; Delayed-Action Preparations; Humans; Hypertension; Nifedipine; | 1990 |
Hypertension in obese children: fasting serum insulin levels are closely correlated with blood pressure.
Topics: Anthropometry; Blood Pressure; Child; Female; Humans; Hypertension; Insulin; Male; Obesity; Probabil | 1990 |
[Uric acid--a risk factor or atherosclerosis marker in type 2 diabetes?].
Topics: Aged; Arteriosclerosis; Biomarkers; Coronary Disease; Diabetes Mellitus, Type 2; Female; Humans; Hyp | 1990 |
[Plasma renin activity, creatinine and uric acid in the serum of patients with essential hypertension].
Topics: Adult; Creatinine; Female; Humans; Hypertension; Male; Renin; Uric Acid | 1990 |
[Parameters of uric acid metabolism in healthy children and in patients with arterial hypertension].
Topics: Adolescent; Child; Circadian Rhythm; Humans; Hypertension; Reference Values; Uric Acid | 1990 |
Obesity, hypertension, hyperuricemia and diabetes mellitus among the Cree and Inuit of northern Québec.
Topics: Adolescent; Adult; Aged; Diabetes Mellitus; Female; Humans; Hypertension; Indians, North American; I | 1990 |
Proteinuria and outcome of 444 pregnancies complicated by hypertension.
Topics: Adult; Birth Weight; Female; Fetal Death; Humans; Hypertension; Infant, Newborn; Infant, Small for G | 1990 |
Effects of reduction in dose and discontinuation of hydrochlorothiazide in patients with controlled essential hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; L | 1990 |
Multiple risk factors in hypertension: results from the Gubbio study.
Topics: Adult; Age Factors; Aged; Antiporters; Carrier Proteins; Erythrocytes; Female; Humans; Hypercholeste | 1990 |
Hyperuricemia-hyperlipemia association in the absence of obesity and alcohol abuse.
Topics: Adult; Alcohol Drinking; Cholesterol; Humans; Hypercholesterolemia; Hyperlipidemias; Hypertension; H | 1990 |
Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries.
Topics: Adult; Blood Pressure; Blood Proteins; Cholesterol; Female; Heart Rate; Humans; Hypertension; Longit | 1990 |
Diabetes mellitus and other cardiovascular risk factors in an elderly population.
Topics: Aged; Aged, 80 and over; Cholesterol; Coronary Disease; Diabetes Mellitus; Female; Humans; Hypertens | 1990 |
Relationship between coronary risk factor and arteriographic feature of coronary atherosclerosis.
Topics: Adult; Aged; Cholesterol; Coronary Angiography; Coronary Artery Disease; Diabetes Complications; Fem | 1990 |
Effects of exercise on blood pressure, plasma catecholamines, potassium and the electrocardiogram after diuretic and neural-blocking therapy for moderate hypertension.
Topics: Blood Pressure; Cardiac Complexes, Premature; Catecholamines; Cholesterol; Drug Therapy, Combination | 1985 |
Arterial disease risk factors and angiographic evidence of atheroma of the carotid artery.
Topics: Aging; Angiography, Digital Subtraction; Arteriosclerosis; Carotid Artery Diseases; Cerebrovascular | 1989 |
[Clinical application of angiotensin converting enzyme inhibitors].
Topics: Angiotensin-Converting Enzyme Inhibitors; Electrolytes; Glucose; Humans; Hypertension; Lipid Metabol | 1989 |
Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects.
Topics: Adult; Aged; Cerebral Hemorrhage; Cerebral Infarction; Creatinine; Cysteine; Dipeptides; Female; Hom | 1989 |
[Plasma fibronectin: a marker of arterial hypertension in pregnancy?].
Topics: Biomarkers; Female; Fibronectins; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiova | 1989 |
[The role of homeostatic function of the kidneys in the development of hyperuricemia].
Topics: Adult; Aged; Blood Proteins; Coronary Disease; Creatinine; Homeostasis; Humans; Hypertension; Kidney | 1989 |
Effects of nicardipine on blood pressure and renal function in elderly hypertensive patients with renal dysfunction.
Topics: Aged; Aldosterone; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Cholesterol; Creatinine; Elec | 1989 |
Effect of captopril on high-density lipoprotein subfractions in patients with mild to moderate essential hypertension.
Topics: Apolipoproteins; Blood Pressure; Body Weight; Captopril; Female; Humans; Hypertension; Lipids; Lipop | 1989 |
[Biochemical plasma changes in essential hypertension patients treated for a year].
Topics: Adult; Antihypertensive Agents; Blood Glucose; Cations; Female; Hemodynamics; Humans; Hypertension; | 1989 |
A ouabain-displacing factor in normal pregnancy, pregnancy-induced hypertension and pre-eclampsia.
Topics: Adult; Aldosterone; Cardenolides; Catecholamines; Digoxin; Female; Humans; Hypertension; Natriuretic | 1988 |
Renal uric acid handling is not affected by beta-adrenoceptor blockade in normotensive subjects.
Topics: Adrenergic beta-Antagonists; Adult; Female; Hemodynamics; Humans; Hypertension; Kidney; Middle Aged; | 1985 |
Stroke and alcohol consumption.
Topics: Adult; Aged; Alcohol Drinking; Aspartate Aminotransferases; Cerebrovascular Disorders; England; Eryt | 1986 |
Hypertension 1986. Evaluation and treatment--why and how.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Glucose; Diuretics; Electrocardiography; | 1986 |
Uric acid in hypertension.
Topics: Benzothiadiazines; Diuretics; Humans; Hypertension; Kidney; Sodium Chloride Symporter Inhibitors; Ur | 1987 |
Renal involvement follows cardiac enlargement in essential hypertension.
Topics: Adult; Cardiac Output; Cardiomegaly; Female; Humans; Hypertension; Kidney Diseases; Male; Middle Age | 1986 |
Blood pressure- and lipid-lowering effect of mackerel and herring diet in patients with mild essential hypertension.
Topics: Adult; Animals; Blood Pressure; Cholesterol; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Aci | 1985 |
The relation of angiotensin-converting enzyme to the pregnancy-induced hypertension-preeclampsia syndrome.
Topics: Adult; Arteries; Birth Weight; Blood Pressure; Blood Urea Nitrogen; Chronic Disease; Female; Fetal B | 1986 |
[Renal transport of uric acid: influence of treatment by converting enzyme inhibitors].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Ur | 1986 |
The metabolic effects of enalapril.
Topics: Adult; Blood Glucose; Blood Pressure; Enalapril; Female; Humans; Hypertension; Lipids; Male; Middle | 1987 |
Intractable gouty arthritis.
Topics: Allopurinol; Arthritis; Colchicine; Duodenal Ulcer; Gout; Humans; Hypertension; Indomethacin; Male; | 1987 |
The adolescent with essential hypertension.
Topics: Adolescent; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Diet, Sodium-Restricted; Furosemi | 1985 |
Uric acid levels: a useful index of the severity of preeclampsia and perinatal prognosis.
Topics: Birth Weight; Female; Humans; Hypertension; Infant, Newborn; Infant, Small for Gestational Age; Pre- | 1988 |
Serum urate, complement 3 and pre-eclampsia in patients with systemic lupus erythematosus.
Topics: Adult; Antihypertensive Agents; Chronic Disease; Complement C3; Female; Humans; Hypertension; Lupus | 1988 |
Clinical alterations in normotensive offspring with parental hypertension.
Topics: Adult; Blood Pressure; Body Weight; Humans; Hypertension; Male; Risk Factors; Triglycerides; Uric Ac | 1988 |
[The value of hypertension and metabolic factors on the development of coronary heart disease in type II diabetic patients].
Topics: Blood Glucose; Cholesterol; Coronary Disease; Diabetes Mellitus, Type 2; Electrocardiography; Humans | 1988 |
Four years' experience with cyclosporine A in pediatric kidney transplantation.
Topics: Child; Cyclosporins; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Graft Survival; G | 1988 |
Hyperinsulinemia--a link between glucose intolerance, obesity, hypertension, dyslipoproteinemia, elevated serum uric acid and internal cation imbalance.
Topics: Adult; Aged; Arteriosclerosis; Blood Glucose; Female; Glucose Tolerance Test; Humans; Hypertension; | 1987 |
Elevated serum uric acid--a facet of hyperinsulinaemia.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Hu | 1987 |
[The effect of inhibitor of angiotensin-converting enzyme on uric acid metabolism].
Topics: Adult; Aged; Captopril; Female; Gout; Humans; Hypertension; Male; Middle Aged; Uric Acid | 1987 |
Plasma uric acid level and its association with diabetes mellitus and some biologic parameters in a biracial population of Fiji.
Topics: Adult; Aged; Black People; Body Constitution; Cholesterol; Diabetes Mellitus; Feeding Behavior; Fema | 1988 |
Altered erythrocyte and plasma sodium and potassium in hypertension, a facet of hyperinsulinemia.
Topics: Erythrocytes; Female; Humans; Hyperinsulinism; Hypertension; Insulin Resistance; Longitudinal Studie | 1988 |
[Measurement of maternal plasma volume during pregnancy].
Topics: Adult; Birth Weight; Female; Fetal Growth Retardation; Humans; Hypertension; Infant, Newborn; Plasma | 1988 |
The effects of intravenous angiotensin II upon blood pressure and sodium and urate excretion in human pregnancy.
Topics: Adult; Angiotensin II; Blood Pressure; Dose-Response Relationship, Drug; Female; Humans; Hypertensio | 1988 |
Changes in serum uric acid during treatment with antihypertensive drugs.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Uric Acid | 1987 |
[Effect of decrease in hyperuricemia levels on joint, kidney and other symptoms in patients with gout].
Topics: Adult; Aged; Allopurinol; Arthritis; Colchicine; Coronary Disease; Gout; Humans; Hypertension; Middl | 1987 |
Possible determinants of blood pressure during childhood (age 4-16 years).
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Female; Humans; Hypertension; Male; Potassium; | 1987 |
Efficacy and tolerance of spironolactone in essential hypertension.
Topics: Aged; Blood Pressure; Creatinine; Dose-Response Relationship, Drug; Drug Evaluation; Female; Gynecom | 1987 |
The effect of relaxing exercise "shavasan".
Topics: Adolescent; Adult; Blood Pressure; Cholesterol; Cold Temperature; Fibrinolysis; Humans; Hypertension | 1987 |
[Hyperuricemia: explain, ignore or treat?].
Topics: Coronary Disease; Female; Gout; Humans; Hypertension; Kidney Calculi; Male; Purines; Risk; Uric Acid | 1986 |
Study to compare the relative hyperuricaemic effects of frusemide and bumetanide.
Topics: Aged; Bumetanide; Diuretics; Edema; Female; Furosemide; Heart Failure; Humans; Hypertension; Male; M | 1986 |
[Effect of hypothiazide and furosemide on different types of metabolism in arterial hypertension].
Topics: Blood Glucose; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Lipoproteins; Potassium; Uric | 1986 |
Hypertension in Slovene schoolchildren population.
Topics: Adolescent; Child; Female; Humans; Hypertension; Longitudinal Studies; Male; Socioeconomic Factors; | 1986 |
[Arterial hypertension in gouty nephropathy].
Topics: Adult; Aged; Blood Pressure; Female; Gout; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; | 1986 |
Factors predictive of perinatal outcome in pregnancies complicated by hypertension.
Topics: Adult; Female; Fetal Death; Humans; Hypertension; Infant Mortality; Infant, Low Birth Weight; Infant | 1986 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Is thiazide-produced uric acid elevation harmful? Analysis of data from the Hypertension Detection and Follow-up Program.
Topics: Adult; Aged; Benzothiadiazines; Chlorthalidone; Creatinine; Diuretics; Female; Follow-Up Studies; Hu | 1987 |
[Hyperuricemia in patients with essential hypertension].
Topics: Adult; Aged; Child; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Uric Acid | 1985 |
Relationships between red cell cation contents and blood pressure level.
Topics: Adult; Aging; Blood Glucose; Blood Pressure; Erythrocytes; Hematocrit; Humans; Hypertension; Middle | 1985 |
An evaluation of factors associated with proliferative diabetic retinopathy.
Topics: Adult; Angina Pectoris; Blood Coagulation; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neurop | 1985 |
Preventive cardiology for coronary artery disease.
Topics: Cholestyramine Resin; Combined Modality Therapy; Coronary Disease; Humans; Hyperlipidemias; Hyperten | 1985 |
Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension.
Topics: Female; Humans; Hypertension; Plasma Volume; Pregnancy; Pregnancy Complications, Cardiovascular; Ren | 1985 |
The development of allopurinol.
Topics: Allopurinol; Animals; Chemistry; Coronary Disease; Gout; History, 20th Century; Humans; Hypertension | 1985 |
[Bilateral retinal vein occlusions and general risk factors].
Topics: Aged; Constriction, Pathologic; Diabetic Retinopathy; Female; Heart Failure; Humans; Hypercholestero | 1985 |
[Etiology and pathogenesis of sudden deafness].
Topics: Adult; Cardiovascular Diseases; Female; Hearing Loss, Sudden; Humans; Hyperglycemia; Hyperlipidemias | 1985 |
Step-down therapy for hypertension. Results of withdrawal from multiple drugs and from a single drug.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Cholesterol; Creatinine; Diuretics; Dose-Res | 1985 |
Step-down therapy for hypertension. Results in a community-based program.
Topics: Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Cholesterol; Fema | 1985 |
Hypertension in pregnancy. A study of 142 women presenting before 32 weeks' gestation.
Topics: Antihypertensive Agents; Clonidine; Diazoxide; Female; Humans; Hydralazine; Hypertension; Infant Mor | 1985 |
[Risk factors in acute myocardial infarct and cerebral ischemic disease].
Topics: Adult; Carotid Arteries; Cerebrovascular Disorders; Cholesterol; Cholesterol, HDL; Electrocardiograp | 1985 |
Gout nephropathy and arterial hypertension.
Topics: Female; Glomerular Filtration Rate; Gout; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; | 1985 |
[Early diagnosis, prevention and basic pathology of EPH gestosis].
Topics: Brain Edema; Diet, Sodium-Restricted; Edema; Energy Intake; Female; Humans; Hypertension; Pre-Eclamp | 1985 |
Role of alcohol in clinical nephrology.
Topics: Acute Kidney Injury; Alcoholism; Blood Glucose; Blood Proteins; Energy Metabolism; Female; Fetal Alc | 1985 |
[Pregnancy and hypertension].
Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Maternal-Fetal Exchange; Pre- | 1985 |
The effects of piretanide capsules on blood pressure during ergometric and isometric work loads in patients with mild to moderate essential hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Capsules; Cholesterol; Creatinine; Diuretics; Female; Hu | 1985 |
[Renal insufficiency and uric gout in a lead worker (clinicopathologic conference)].
Topics: Aged; Gout; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Lead Poisoning; Male; Myocardium; | 1985 |
[Blood uric acid and arterial hypertension in pregnancy. Interpretation and prognostic value].
Topics: Female; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Prognosis; Uric Ac | 1985 |
[Relation between arterial pressure and various biological factors in serum].
Topics: Arteries; Beta-Globulins; Blood Chemical Analysis; Blood Glucose; Blood Pressure; Blood Proteins; Ch | 1972 |
Side effects of antihypertensive drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazine | 1974 |
Problems faced by hypertensive patients.
Topics: Adrenergic beta-Antagonists; Allopurinol; Blood Pressure; Contraceptives, Oral; Diuretics; Family Pr | 1973 |
Hypertension and hyperuricaemia.
Topics: Adolescent; Adult; Aged; Blood; Cerebrovascular Disorders; Cobalt Isotopes; Coronary Disease; Female | 1966 |
Hyperuricaemia, gout, and diabetic abnormality in Polynesian people.
Topics: Adult; Aged; Blood; Blood Pressure; Diabetes Mellitus; Ethnology; Female; Glucose Tolerance Test; Gl | 1966 |
Hyperuricaemia, hypertension, and vascular disease.
Topics: Humans; Hypertension; Uric Acid; Vascular Diseases | 1967 |
[Ist results of a prospective survey on cardiovascular diseases in a large enterprise].
Topics: Adult; Age Factors; Angina Pectoris; Arteriosclerosis; Cardiovascular Diseases; Cholesterol; France; | 1973 |
Amniotic fluid tests for fetal maturity.
Topics: Amniotic Fluid; Bilirubin; Centrifugation; Chlorides; Creatinine; Embryonic and Fetal Development; F | 1974 |
[Incidence of primary hyperuricemia in ambulant patients (author's transl)].
Topics: Adult; Age Factors; Aged; Ambulatory Care; Blood Protein Disorders; Diabetes Mellitus; Female; Germa | 1974 |
Etiologic varieties of hyperuricemia and gout.
Topics: Acute Kidney Injury; Diabetic Ketoacidosis; Down Syndrome; Female; Gout; Hematologic Diseases; Human | 1974 |
[Clinical trial of a new antihypertensive agent].
Topics: Adult; Aged; Antihypertensive Agents; Blood Urea Nitrogen; Female; Furosemide; Humans; Hypertension; | 1969 |
[Clarification of a hypertension].
Topics: Aldosterone; Angiotensin II; Aortic Coarctation; Blood Pressure Determination; Creatinine; Cushing S | 1970 |
Renal function in pregnancy.
Topics: Aldosterone; Angiotensin II; Catecholamines; Estrogens; Female; Glomerular Filtration Rate; Glycosur | 1972 |
[The genesis of hyperuricemia in patients with essential hypertension (author's transl)].
Topics: Adult; Angiotensin II; Biological Transport; Blood Pressure; Body Weight; Creatinine; Electrolytes; | 1974 |
[Arterial hypertension in the young adult. Systematic exploration of 100,000 young people].
Topics: Adult; Central Nervous System; France; Glycosuria; Heart; Humans; Hypertension; Kidney; Lipoproteins | 1974 |
[Coronaropathies in the black African. Clinical, etiological and current epidemiological aspects (apropos of 45 cases)].
Topics: Adult; Age Factors; Aged; Angina Pectoris; Black People; Coronary Disease; Cote d'Ivoire; Diabetes C | 1974 |
[Diuretics and serum uric acid].
Topics: Aged; Diuretics; Female; Heart Diseases; Humans; Hypertension; Male; Uric Acid | 1974 |
[Diuretics in modern treatment of hypertension].
Topics: Aged; Blood Pressure; Chlorthalidone; Female; Humans; Hypertension; Male; Middle Aged; Potassium; Ur | 1974 |
[Metabolism of uric acid and lactic acid in essential arterial hypertension].
Topics: Adolescent; Adult; Age Factors; Diuretics; Female; Gout; Humans; Hypertension; Lactates; Male; Middl | 1974 |
[Effects of coffee during good health and in disease from the medical standpoint].
Topics: Acute Disease; Aged; Blood Pressure; Caffeine; Cerebrovascular Disorders; Coffee; Diabetes Mellitus; | 1974 |
Do medical conditions have an influence on central retinal vein occlusions?
Topics: Age Factors; Arterial Occlusive Diseases; Blood Viscosity; Diabetic Angiopathies; Hemoglobins; Human | 1974 |
[Hypertension with low level of plasma renin. An epidemiologic study].
Topics: Adult; Age Factors; Aged; Blood Pressure; Cholesterol; Creatinine; Female; Humans; Hypertension; Mal | 1974 |
[Diabetes and hyperuricaemia (author's transl)].
Topics: Adult; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Diabetes Complications; Diabetes Mel | 1974 |
Tolerance and side-effects of the association hydrochlorothiazide-amiloride in long-term treatment of arterial hypertension.
Topics: Adult; Aged; Amiloride; Calcium; Creatinine; Drug Combinations; Drug Tolerance; Humans; Hydrochlorot | 1974 |
Effect of Milurit on decreasing hyperuricaemia in hypertensive patients.
Topics: Allopurinol; Glomerular Filtration Rate; Gout; Humans; Hypertension; Thiazines; Uric Acid | 1974 |
[Hyperuricemia in hypertension (author's transl)].
Topics: Adult; Age Factors; Aged; Female; Humans; Hypertension; Male; Middle Aged; Obesity; Uric Acid | 1974 |
[Thiazide diuretics and sugar-uric acid metabolism].
Topics: Benzothiadiazines; Diuretics; Female; Glucose; Humans; Hypertension; Male; Middle Aged; Sodium Chlor | 1974 |
Current medical practice and the Food and Drug Administration. Some evidence for the existing gap.
Topics: Adult; Aged; Allopurinol; Angina Pectoris; Cephalexin; Child; Colchicine; Diuretics; Drug Labeling; | 1974 |
Coronary artery disease in young women.
Topics: Adolescent; Adult; Age Factors; Arteriosclerosis; Body Weight; Carbohydrate Metabolism, Inborn Error | 1974 |
Serum uric acid in normal and hypertensive Australian subjects.
Topics: Adolescent; Adult; Age Factors; Australia; Child; Colorimetry; Debrisoquin; Female; Guanethidine; Hu | 1972 |
Coronary heart disease in young men: a study of seventy patients with a critical review of etiological factors.
Topics: Adult; Australia; Body Height; Body Weight; Cholesterol, Dietary; Coronary Disease; Diabetes Complic | 1973 |
Alteration of urate metabolism by weight reduction.
Topics: Gout; Humans; Hypertension; Male; Metabolic Clearance Rate; Middle Aged; Obesity; Uric Acid | 1973 |
Cardiovascular epidemiology in New Zealand and the Pacific.
Topics: Adult; Aged; Anthropometry; Blood Pressure; Cardiovascular Diseases; Cholesterol; Coronary Disease; | 1974 |
[Antihypertensive long term therapy with a furosemide-reserpine combination].
Topics: Aged; Carbohydrate Metabolism; Drug Combinations; Female; Furosemide; Humans; Hypertension; Long-Ter | 1972 |
Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma.
Topics: Adult; Chlorthalidone; Dehydration; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans; | 1972 |
[The kidney and hyperuricemia].
Topics: Female; Glomerular Filtration Rate; Gout; Humans; Hypertension; Kidney Diseases; Kidney Function Tes | 1972 |
Renin activity, sodium and potassium in hypertensive patients.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Urea Nitrogen; Carbon Dioxide | 1972 |
[Epidemiology of cerebral vascular occlusions].
Topics: Adult; Age Factors; Cerebrovascular Disorders; Cholesterol; Diabetic Angiopathies; Encephalomalacia; | 1972 |
Management of renal disease in pregnancy.
Topics: Acute Disease; Anti-Infective Agents, Urinary; Bacteriuria; Chronic Disease; Diabetic Nephropathies; | 1972 |
[Relationship between metabolic diseases and the severity of coronary disease].
Topics: Angina Pectoris; Angiocardiography; Cholesterol; Diabetes Complications; Diabetic Angiopathies; Fema | 1972 |
Risk factors in coronary heart disease: possibilities of prevention in the Federal Republic of West Germany.
Topics: Age Factors; Body Weight; Cholesterol; Diabetes Complications; Europe; Female; Germany, West; Hepari | 1972 |
[Changes between 1948 and 1970 in the epidemiology and clinical features of primary gout].
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Blood Protein Disorders; Diabetes Complications; Fatty L | 1973 |
[Arterial hypertension with convulsive seizures in a patient with right kidney hypoplasia and gout attacks and with a probable gouty kidney].
Topics: Electrocardiography; Gout; Headache; Heart; Humans; Hydronephrosis; Hypertension; Kidney; Kidney Dis | 1973 |
[Treatment with allopurinol in gout and hyperuricemic renal disease].
Topics: Adult; Aged; Allopurinol; Creatinine; Female; Glomerular Filtration Rate; Gout; Humans; Hypertension | 1973 |
Platelets and vascular disease in gout.
Topics: Allopurinol; Analgesics; Arteriosclerosis; Blood Platelets; Colchicine; Diabetes Complications; Gout | 1973 |
[Long-term therapy of gout and hyperuricemia].
Topics: Allopurinol; Arteriosclerosis; Blood Protein Disorders; Citrates; Colchicine; Diabetes Mellitus; Die | 1973 |
Correlates and consequences of asymptomatic hyperuricemia.
Topics: ABO Blood-Group System; Adult; Aspartate Aminotransferases; Blood Glucose; Calcium; Cholesterol; Cre | 1973 |
Screening for hypertension in an epidemiological study.
Topics: Adult; Angina Pectoris; Blood Pressure; Cholesterol; Creatinine; Denmark; Electrocardiography; Eye M | 1973 |
A comparison of moduretic and hydrochlorothiazide in the treatment of hypertension in African patients.
Topics: Adult; Aged; Amiloride; Blood Pressure; Diuretics; Electrolytes; Female; Humans; Hydrochlorothiazide | 1973 |
[Relation of blood pressure to the body weight index and to metabolic parameters].
Topics: Adolescent; Adult; Age Factors; Aged; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Diet, | 1973 |
Pregnancy bacteriuria: the significance of site of infection.
Topics: Anemia; Antibodies, Bacterial; Bacteriuria; Female; Fetal Death; Humans; Hypertension; Kidney Diseas | 1973 |
Automatic ECG and blood pressure measurement in multitesting: correlation of blood pressure and ECG abnormalities.
Topics: Adult; Aged; Blood Glucose; Blood Pressure Determination; Blood Urea Nitrogen; Body Weight; Choleste | 1973 |
Familial hyperuricaemia and hypertriglyceridaemia.
Topics: Adolescent; Adult; Alcohol Drinking; Blood Pressure; Cholesterol; Female; Gout; Humans; Hyperlipidem | 1973 |
Serum uric acid. Its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia.
Topics: Adolescent; Adult; Age Factors; Black People; Blood Glucose; Blood Pressure; Body Height; Body Weigh | 1973 |
Urolithiasis and nephropathy in gout.
Topics: Adult; Aged; Albuminuria; Female; Gout; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Ur | 1973 |
[Hyperuricemia. (Etiopathogenic and therapeutic concepts)].
Topics: Diuretics; Gout; Humans; Hypertension; Hypothyroidism; Kidney Diseases; Nicotinic Acids; Nucleoprote | 1973 |
Uric acid and the kidney.
Topics: Aged; Allopurinol; Animals; Diabetes Mellitus; Gout; Humans; Hydrogen-Ion Concentration; Hypercholes | 1973 |
A critical evaluation of renal protein selectivity in pregnancy.
Topics: Creatinine; Female; Fetal Death; Humans; Hypertension; Immunoglobulin G; Kidney; Molecular Weight; P | 1974 |
[Arterial hypertension. Diagnosis and therapy in practice].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Electrocardiography; Exercise Ther | 1974 |
Diseases associated with calcium pyrophosphate dihydrate crystal deposition.
Topics: Adult; Aged; Calcium; Chondrocalcinosis; Creatinine; Diabetes Complications; Female; Gout; Hemochrom | 1974 |
Diuretic and diet treatment of hypertension.
Topics: Benzothiadiazines; Blood Volume; Chlorthalidone; Creatinine; Diet, Sodium-Restricted; Diuretics; Eth | 1974 |
The effect of weight reduction on urate metabolism.
Topics: Blood Pressure; Body Weight; Carbon Radioisotopes; Creatinine; Diet Therapy; Glycine; Gout; Humans; | 1974 |
Relationship between gout and arterial hypertension.
Topics: Acute Disease; Adult; Aged; Blood Pressure; Chronic Disease; Diabetes Complications; Female; Gout; H | 1974 |
Observations concerning the incidence of disturbance of lipid and carbohydrate metabolism in gout.
Topics: Arteriosclerosis; Blood Glucose; Body Weight; Cholesterol; Coronary Disease; Diabetes Complications; | 1974 |
[A comparative study of spironolactone and chlorthalidone in treatment of hypertension].
Topics: Adult; Blood Glucose; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Male; | 1974 |
High doses of furosemide and sodium in hypertension. A single therapeutic measure in severe cases.
Topics: Administration, Oral; Blood Pressure; Body Weight; Creatinine; Diet; Female; Furosemide; Humans; Hyp | 1974 |
Use of metolazone, a new diuretic, in patients with renal disease.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Glucose; Blood Pressure; Creatinine; Diu | 1974 |
Retrospective study of men who had undergone myocardial infarction at the age of 40 years or younger.
Topics: Adult; Age Factors; Aged; Aging; Angina Pectoris; Arteriosclerosis; Blood Glucose; Blood Pressure; C | 1974 |
[A new concept of preventive medicine using automatic data processing by computer. II. Application to diseases and risks of the digestive apparatus and to cardiovascular diseases and risks].
Topics: Alcoholism; Blood Glucose; Body Height; Body Weight; Cardiovascular Diseases; Cholesterol; Computers | 1969 |
[Prolonged fasting as a method of treating obesity].
Topics: Acid-Base Equilibrium; Aged; Coronary Disease; Diabetes Mellitus; Diabetic Ketoacidosis; Fasting; Fa | 1967 |
Chlorothiazide and probenecid in the treatment of hypertension and hyperuricemia.
Topics: Chlorothiazide; Female; Glucose Tolerance Test; Humans; Hypertension; Male; Middle Aged; Probenecid; | 1968 |
Methyldopa-chlorothiazide--a long-term evaluation.
Topics: Adult; Aged; Anemia, Hemolytic; Chlorothiazide; Coombs Test; Drug Tolerance; Female; Humans; Hyperte | 1970 |
[First results of the application to cardiovascular diseases of a new preventive medicine concept using automatic treatment of the information by computer].
Topics: Adult; Aged; Angina Pectoris; Body Weight; Cardiovascular Diseases; Computers; Diabetes Mellitus; El | 1971 |
Laboratory characteristics in toxemia.
Topics: Blood Glucose; Blood Proteins; Calcium; Cerebrospinal Fluid Proteins; Color; Erythrocytes; Female; G | 1972 |
The influences of rate of injection upon the effects of diazoxide.
Topics: Adult; Aged; Aminohippuric Acids; Blood Pressure; Chlorides; Creatinine; Diazoxide; Female; Humans; | 1972 |
[Gout, diabetes mellitus and fatty liver].
Topics: Adult; Arteriosclerosis; Body Weight; Diabetes Complications; Fatty Liver; Female; Gout; Humans; Hyp | 1972 |
[Missed gout].
Topics: Arteriosclerosis; Arthritis, Rheumatoid; Diagnosis, Differential; Gout; Humans; Hypertension; Kidney | 1972 |
Coronary heart disease: risk factors as guides to preventive action.
Topics: Adult; Coronary Disease; Dietary Fats; Female; Humans; Hypercholesterolemia; Hyperglycemia; Hyperten | 1972 |
Trial of mefruside.
Topics: Diuretics; Humans; Hypertension; Hypokalemia; Sulfonic Acids; Uric Acid | 1972 |
The incidence of hypertension and associated factors: the Israel ischemic heart disease study.
Topics: Adult; Age Factors; Aged; Body Height; Body Weight; Education; Family Characteristics; Humans; Hyper | 1972 |
Hyperuricemia in health and disease.
Topics: Arteriosclerosis; Arthritis; Blood Group Antigens; Carbohydrate Metabolism; Diabetes Complications; | 1972 |
[Relations between diet and atherosclerosis].
Topics: Adult; Age Factors; Arteriosclerosis; Coronary Disease; Diet; Dietary Carbohydrates; Dietary Fats; D | 1971 |
[Clinical symptoms and progress of gout complicated by urolithiasis].
Topics: Adult; Aged; Diabetes Complications; Female; Gout; Humans; Hypertension; Male; Middle Aged; Obesity; | 1971 |
[Uric acid abnormalities in juveniles. Peculiarities of the clinical picture].
Topics: Adolescent; Adult; Diabetes Complications; Diagnosis, Differential; Fatty Liver; Gout; Humans; Hyper | 1971 |
[Serum uric acid levels and the occurrence of hyperuricemia].
Topics: Adolescent; Adult; Age Factors; Aged; Blood Pressure Determination; Body Weight; Cerebrovascular Dis | 1971 |
[Content of uric acid in the blood of patients with atherosclerosis].
Topics: Adult; Aged; Animals; Arteriosclerosis; Cholesterol; Female; Humans; Hypertension; Male; Middle Aged | 1971 |
Effects of hypotonic expansion on sodium and water excretion in hypertensive non-pre-eclamptic gravidas.
Topics: Aminohippuric Acids; Diuresis; Extracellular Space; Female; Humans; Hypertension; Hypotonic Solution | 1971 |
Hyperuricemia and gout in an employee population.
Topics: Adult; Age Factors; Alcoholism; Coronary Disease; Diabetes Complications; Diuretics; Gout; Humans; H | 1971 |
Metabolic factors in the epidemiology of arterial disease.
Topics: Adult; Age Factors; Arteriosclerosis; Blood Glucose; Blood Pressure; Body Weight; Cerebrovascular Di | 1971 |
[Hyperuricemia induced by diuretics in hypertensive patients. Curative and preventive treatment with benziodarone].
Topics: Adult; Benzofurans; Diuretics; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle A | 1971 |
Lactic acid and hyperuricemia of faulty renal urate transport.
Topics: Female; Glycogen Storage Disease; Gout; Humans; Hypertension; Kidney Diseases; Lactates; Pre-Eclamps | 1967 |
High blood pressure in men aged 50--a population study of men born in 1913.
Topics: Blood Glucose; Blood Pressure Determination; Blood Sedimentation; Blood Volume; Communicable Disease | 1967 |
An evaluation of serum uric acid estimations in toxaemia of pregnancy.
Topics: Female; Humans; Hypertension; Male; Pre-Eclampsia; Pregnancy; Uric Acid | 1968 |
[Diagnostic value of hyperuricemia].
Topics: Adult; Allopurinol; Child; Diabetes Mellitus; Female; Glycogen Storage Disease; Gout; Humans; Hypert | 1968 |
Drug-induced hyperuricemia prevented by probenecid.
Topics: Adult; Aged; Female; Gout; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Probenecid; | 1971 |
[Basic concepts of physics for the interpretation of the curative effect of radioactive mineral waters].
Topics: Female; Genital Diseases, Female; Gout; Humans; Hypertension; Infertility, Female; Joint Diseases; M | 1969 |
Platelet aggregation in several cardiovascular diseases determined with a modified screen filtration pressure method.
Topics: Adenine Nucleotides; Adolescent; Adult; Blood Platelets; Cardiovascular Diseases; Cell Aggregation; | 1970 |
[Clinical findings and therapy of gout with special reference to the metabolic effects of sulfinpyrazone (Anturan) and allopurinol (Zyloric)].
Topics: Allopurinol; Diabetes Mellitus; Gout; Humans; Hypertension; Kidney Diseases; Male; Sulfinpyrazone; U | 1969 |
[Renal excretion of sodium and uric acid in arterial hypertension under the acute influence of saluretics].
Topics: Adolescent; Adult; Aged; Diuresis; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Osmo | 1969 |
[Advantage of the diuretic "thiazide-spironolactone" associati in the treatment of arterial hypertension].
Topics: Benzothiadiazines; Blood Glucose; Blood Urea Nitrogen; Creatinine; Drug Synergism; Glomerular Filtra | 1969 |
[Risk factors for heart and circulatory diseases in an aged population. Pilot study in a home for the aged].
Topics: Adult; Aged; Cardiovascular Diseases; Cholesterol; Diet; Electrocardiography; Female; Geriatrics; He | 1969 |
[Experiences with a new salureticum in essential hypertension].
Topics: Adult; Age Factors; Aged; Antihypertensive Agents; Blood Chemical Analysis; Blood Circulation; Blood | 1969 |
[Therapy of chronic kidney failure].
Topics: Creatinine; Diet Therapy; Diet, Sodium-Restricted; Dietary Proteins; Humans; Hypertension; Kidney Fa | 1969 |
Acute pancreatitis, hypercalcemia, hyperuricemia, and hypertension secondary to parathyroid adenoma.
Topics: Humans; Hypercalcemia; Hyperparathyroidism; Hypertension; Male; Middle Aged; Pancreatitis; Phosphoru | 1970 |
[Guidelines for therapy with diuretics].
Topics: Alkalosis; Carbohydrate Metabolism; Diuretics; Drug Synergism; Glaucoma; Humans; Hypertension; Hypok | 1970 |
The influence of hypertonic saline infusions upon the fractional reabsorption of urate and other ions in normal and hypertensive man.
Topics: Biological Transport; Blood Pressure; Calcium; Chlorides; Depression, Chemical; Glomerular Filtratio | 1970 |
Role of posture in sodium, water, and potassium homeostasis of an abnormal pregnancy.
Topics: Adolescent; Aminohippuric Acids; Blood Pressure; Creatinine; Diet Therapy; Diuresis; Female; Glomeru | 1970 |
Diagnosis of gout.
Topics: Albuminuria; Arthritis; Arthritis, Rheumatoid; Colchicine; Colic; Diagnosis, Differential; Gout; Hum | 1970 |
Visceral (nonarticular) manifestations associated with gout.
Topics: Acute Kidney Injury; Arteriosclerosis; Gout; Humans; Hypertension; Kidney Calculi; Radiography; Uric | 1970 |
Chlorthalidone in the long term therapy of patients with hypertension.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Glucose; Blood Pressure; Carbohydrate Metabolism, Inborn | 1970 |
Diuretics and hyperuricemia.
Topics: Allopurinol; Diuretics; Gout; Humans; Hypertension; Uric Acid; Uricosuric Agents | 1970 |
[Long-term treatment of hypertensive disease "in the vascular sclerosis phase" with furosemide and reserpine. Clinico-statistical and hematochemical considerations].
Topics: Adult; Aged; Arteriosclerosis; Blood Glucose; Electrolytes; Female; Furosemide; Humans; Hypertension | 1970 |
[Clinical aspects of arthrosis].
Topics: Adult; Age Factors; Aged; Ankle Joint; Brachial Plexus Neuritis; Cervical Vertebrae; Female; Hand; H | 1970 |
Hypertension, hyperuricemia and iatrogenic disease.
Topics: Aged; Allopurinol; Aortic Diseases; Arteriosclerosis; Brain; Catheterization; Chlorothiazide; Diagno | 1970 |
Preliminary results from high-resolution analyses of ultraviolet-absorbing and carbohydrate constituents in several pathologic body fluids.
Topics: Adolescent; Adult; Alkaptonuria; Allopurinol; Amniotic Fluid; Athetosis; Carbohydrates; Chorea; Chro | 1970 |
Clinical survey of 354 patients with gout.
Topics: Adolescent; Adult; Age Factors; Aged; Alcohol Drinking; Blood Urea Nitrogen; Body Weight; Child; Com | 1970 |
Hyperglycaemia in the urbanized Aboriginal. The Davenport survey.
Topics: Activities of Daily Living; Adolescent; Adult; Australia; Blood Glucose; Child; Cholesterol; Civiliz | 1970 |
[Effect of hypothiazide on the urinary excretion of uric acid in patients with hypertensive disease].
Topics: Antihypertensive Agents; Diuretics; Humans; Hypertension; Time Factors; Uric Acid | 1970 |
Antihypertensive effect of a new imidazoline compound (clonidine) and chlorthalidone, individually and in combination.
Topics: Adult; Aged; Alkaline Phosphatase; Aniline Compounds; Antihypertensive Agents; Blood Glucose; Blood | 1970 |
[Dietary management of hazard factors in cardiovascular diseases].
Topics: Aged; Cardiovascular Diseases; Diabetes Complications; Diet Therapy; Humans; Hypercholesterolemia; H | 1970 |
Effect of spironolactone in hypertensive patients.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Antihypertensive Agents; Blood Urea Nitrogen; Fema | 1970 |
[Physiopathology of essential hypertension].
Topics: Adrenal Glands; Body Constitution; Diabetes Complications; Hemodynamics; Humans; Hypertension; Kidne | 1970 |
[Current problems of gout].
Topics: Blood Glucose; Cholesterol; Coronary Disease; Diabetes Complications; Female; Gout; Humans; Hypercho | 1970 |
Interaction between psychic and somatic risk factors of myocardial infarction.
Topics: Adult; Cholesterol; Humans; Hypertension; Male; Middle Aged; Myocardial Infarction; Obesity; Persona | 1970 |
[Diabetes mellitus, hyperlipemia, fatty liver, hypertension in primary gout and their influencing by benzbromaronum].
Topics: Adult; Benzofurans; Blood Glucose; Blood Sedimentation; Colchicine; Creatinine; Diabetes Mellitus; E | 1970 |
[Incidence of hyperlipemia, hyperuricemia, diabetes mellitus, hypertension and overweight in arterial obliterating disease].
Topics: Adult; Aged; Arteriosclerosis Obliterans; Blood Glucose; Body Weight; Cholesterol; Diabetic Angiopat | 1971 |
[Ocular findings in gout and hyperuricemia].
Topics: Adult; Eye Diseases; Gout; Humans; Hypertension; Male; Middle Aged; Uric Acid | 1971 |
[Alterations of lipid metabolism in primary gout and hyperuircemia].
Topics: Adult; Aged; Blood Glucose; Cholesterol; Diabetes Mellitus; Fatty Acids; Fatty Acids, Nonesterified; | 1971 |
[The kidneys and hyperuricemia. Therapeutic problems].
Topics: Gout; Humans; Hypertension; Kidney Diseases; Uric Acid | 1971 |
The aetiology and possible prevention of myocardial infarction.
Topics: Adult; Age Factors; Aged; Calcium; Diabetes Complications; Female; Humans; Hyperlipidemias; Hyperten | 1971 |
Distribution and multiple regression analysis of blood pressure in 10,000 Israeli men.
Topics: Adult; Africa, Northern; Age Factors; Aged; Analysis of Variance; Anxiety; Asia; Blood Pressure; Bod | 1971 |
[Ischemic heart disease and so-called risk factors--results of an epidemiological study in Erfurt].
Topics: Angina Pectoris; Blood Glucose; Cardiovascular Diseases; Computers; Coronary Disease; Fatty Acids, E | 1971 |
The causes of nonazotemic hyperuricemia.
Topics: Adult; Age Factors; Animals; Arteriosclerosis; Blood Urea Nitrogen; Computers; Coronary Disease; Dia | 1971 |
[Hyperuricemia due to diuretics in hypertensive patients. Curative treatment with benziodarone].
Topics: Adult; Benzofurans; Diuretics; Female; Humans; Hypertension; Kidney Function Tests; Male; Middle Age | 1971 |
[Management of hypertension with fursemid-reserpine].
Topics: Adult; Aged; Blood Cell Count; Blood Glucose; Blood Pressure; Creatinine; Female; Furosemide; Humans | 1967 |
[The BBC study. Applied epidemiology of ischemic heart diseases].
Topics: Adult; Body Weight; Caffeine; Cholesterol; Coronary Disease; Epidemiologic Methods; Hematocrit; Huma | 1967 |
[Arterial hypertension and hyperuricemia].
Topics: Humans; Hypertension; Uric Acid | 1967 |
[Arterial hypertension and hyperuricemia].
Topics: Arteries; Humans; Hypertension; Uric Acid | 1967 |
[Comparison between blood uric acid values in normal aged patients and in hypertensive, obese or diabetic subjects].
Topics: Aged; Aging; Diabetes Mellitus; Female; Humans; Hypertension; Male; Obesity; Uric Acid | 1967 |
[Changes in blood uric acid during prolonged treatment with diuretic-hypotensive drugs in aged patients].
Topics: Aged; Arteriosclerosis; Chlorthalidone; Female; Humans; Hypertension; Male; Middle Aged; Reserpine; | 1967 |
Ischemic cerebrovascular disease. The assessment of risk factors.
Topics: Adult; Age Factors; Aged; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Disorders; Coronary D | 1968 |
Ultrastructural studies in hypertension. 3. Gouty nephropathy.
Topics: Adult; Aged; Animals; Biopsy; Gout; Humans; Hypertension; Kidney; Kidney Glomerulus; Kidney Tubules; | 1968 |
[Study in man of the kinetics of the appearance of uric acid 2-14C in the urine].
Topics: Aminohippuric Acids; Carbon Isotopes; Humans; Hypertension; Indicators and Reagents; Injections, Int | 1968 |
Nephropathy in chronic lead poisoning.
Topics: Adult; Chronic Disease; Colic; Creatinine; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Ki | 1968 |
[Gout in women].
Topics: Adolescent; Adult; Age Factors; Aged; Blood Pressure; Calculi; Female; Germany, West; Gout; Humans; | 1968 |
The clinical differentiation of lead gout from primary gout.
Topics: Alcohol Drinking; Body Height; Body Weight; Child Behavior Disorders; Diagnosis, Differential; Envir | 1968 |
Gout in India. (A study of clinical features).
Topics: Adolescent; Adult; Female; Gout; Humans; Hypertension; India; Male; Middle Aged; Uremia; Uric Acid | 1968 |
The interpretation of radioactive uric acid turnover data.
Topics: Arthritis, Rheumatoid; Biological Assay; Carbon Isotopes; Gout; Humans; Hypertension; Myocardial Inf | 1968 |
[Uric acid, hypertension, blood vessels and serum lipids].
Topics: Cardiovascular Diseases; Cholesterol; Diuretics; Humans; Hyperglycemia; Hypertension; Kidney Disease | 1968 |
[Effect of hypothiazide on the uric acid content of blood plasma and erythrocytes in patients with hypertensive disease].
Topics: Chlorothiazide; Erythrocytes; Humans; Hypertension; Uric Acid | 1968 |
[Arterial hypertension and hyperuricemia].
Topics: Humans; Hypertension; Uric Acid | 1968 |
[Blood uric acid in arterial hypertension].
Topics: Humans; Hypertension; Kidney Diseases; Uric Acid | 1968 |
Hypertension, hyperuricemia and azotemia.
Topics: Aged; Chronic Disease; Diagnosis, Differential; Humans; Hypertension; Male; Nephrosclerosis; Nitroge | 1968 |
[Gout in advanced age].
Topics: Age Factors; Aged; Allopurinol; Bone and Bones; Cardiovascular Diseases; Colchicine; Female; Gout; H | 1968 |
[Indices of the clearance of endogenous creatinine, urea and uric acid in patients with arterial hypertension].
Topics: Adult; Aged; Creatinine; Female; Humans; Hypertension; Kidney Function Tests; Male; Middle Aged; Ure | 1969 |
[Factors of coronary risk].
Topics: Castration; Coronary Disease; Dietary Fats; Heart Diseases; Humans; Hyperglycemia; Hypertension; Neu | 1969 |
Differential uric acid excretion in essential and renal hypertension.
Topics: Atrophy; Glomerular Filtration Rate; Humans; Hydronephrosis; Hypertension; Hypertension, Renal; Kidn | 1969 |
Studies of uric acid pool size and turnover rate.
Topics: Adolescent; Adult; Aged; Allopurinol; Carbon Isotopes; Female; Gout; Humans; Hypertension; Male; Mat | 1969 |
[Basic treatment of coronary atherosclerosis].
Topics: Activities of Daily Living; Angina Pectoris; Anticoagulants; Cholesterol; Cholestyramine Resin; Coro | 1969 |
Evaluation of renal biopsy in pregnancy toxemia.
Topics: Adolescent; Adult; Biopsy; Blood Urea Nitrogen; Creatinine; Female; Gestational Age; Humans; Hyperte | 1969 |
[Clinical findings and therapy of gout].
Topics: Adult; Age Factors; Aged; Diabetes Complications; Diet Therapy; Female; Gout; Humans; Hypertension; | 1969 |
Ultrastructural studies in hypertension. IV. Toxemia of pregnancy.
Topics: Biopsy; Blood Urea Nitrogen; Capillaries; Creatinine; Female; Hypertension; Juxtaglomerular Apparatu | 1969 |
[Thiazide therapy of hypertension and its effect on hyperuricemia].
Topics: Adult; Aged; Blood Pressure; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Tric | 1969 |
[Studies on uric acid metabolism disorders following administration of saluretics].
Topics: Chlorothiazide; Chlorthalidone; Ethacrynic Acid; Furosemide; Humans; Hydrochlorothiazide; Hydroflume | 1965 |
Correlations among hyperuricemia, hypercholesterolemia, coronary disease and hypertension.
Topics: Blood; Coronary Disease; Epidemiologic Methods; Gout; Humans; Hypercholesterolemia; Hypertension; Ur | 1965 |
[The hypotensive action of DT 327. Contribution to the hyperuricemic effect of the thiazide diuretics].
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; In Vitro Techniques; Male; Middle Aged; Uric A | 1965 |
[Modifications of blood uric acid and urinary uric acid induced by treatment with hydrochlorothiazide in aged subjects].
Topics: Aged; Blood; Heart Diseases; Humans; Hydrochlorothiazide; Hypertension; In Vitro Techniques; Uric Ac | 1965 |
The effects of intra-venous diazoxide, a non-diuretic thiazide, upon blood pressure, electrolyte, and uric acid excretion.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Chlorothiazide; Diazoxide; Electrolytes; Humans; Hyp | 1966 |
Cardiorenal hemodynamic effects of ethacrynic acid.
Topics: Chlorothiazide; Diabetes Insipidus; Edema; Electrolytes; Ethacrynic Acid; Heart; Heart Failure; Hear | 1966 |
[Blood uric acid levels in persons with essential arterial hypertension].
Topics: Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Uric Acid | 1966 |
Hyperuricemia in primary and renal hypertension.
Topics: Adolescent; Adult; Aged; Blood Urea Nitrogen; Female; Glomerular Filtration Rate; Humans; Hyperchole | 1966 |
Effects of MK-870 in normal subjects and hypertensive patients.
Topics: Adult; Aged; Amidines; Blood Urea Nitrogen; Creatine; Diuretics; Humans; Hydrochlorothiazide; Hypert | 1966 |
Potassium depletion produced by administration of chlorthalidone to nonedematous patients with arterial hypertensin.
Topics: Adult; Alkalosis; Blood Urea Nitrogen; Carbon Dioxide; Chlorine; Chlorthalidone; Creatine; Female; H | 1966 |
Hypertension and hyperuricaemia.
Topics: Blood; Female; Humans; Hypertension; Kidney; Kidney Tubules; Male; Uric Acid | 1966 |
Absence of peripheral pulse in relation to other arterial disease in a community study.
Topics: Adolescent; Adult; Aged; Alcoholic Beverages; Blood Glucose; Body Weight; Cerebral Arterial Diseases | 1966 |
Drug control of diuretic-induced hyperuricemia.
Topics: Blood; Chlorothiazide; Humans; Hydrochlorothiazide; Hypertension; Probenecid; Sulfonamides; Uric Aci | 1966 |
Allopurinol in thiazide-induced hyperuricaemia.
Topics: Allopurinol; Clopamide; Enzyme Therapy; Gout; Hematologic Diseases; Humans; Hypertension; Kidney Fai | 1966 |
[The infarct profile. Differences between infarct patients and control subjects in Eastern Switzerland].
Topics: Adult; Age Factors; Aged; Angina Pectoris; Arthritis; Body Height; Body Weight; Cholesterol; Diabete | 1966 |