Page last updated: 2024-10-20

uric acid and Hypertension, Renal

uric acid has been researched along with Hypertension, Renal in 70 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.

Research Excerpts

ExcerptRelevanceReference
"As oxonic acid diet increased plasma renin activity, plasma aldosterone, and urine K to Na ratio, these changes may play a significant role in the harmful cardiovascular actions of hyperuricemia."7.74Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. ( Eräranta, A; Kööbi, P; Kurra, V; Lakkisto, P; Mustonen, JT; Niemelä, OJ; Pörsti, IH; Tahvanainen, AM; Tikkanen, I; Vehmas, TI, 2008)
"To study whether the renin-angiotensin system is related to hyperuricemia in hypertension, the serum concentration of uric acid was determined in 96 patients with various types of hypertension and various degrees of plasma renin activity (PRA)."7.66Serum uric acid and the renin-angiotensin system in hypertension. ( Kato, E; Kondo, K; Nakamura, R; Oguro, T; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978)
"The objectives of this study were to compare the effects of the angiotensin II receptor blocker, losartan, to those of the angiotensin-converting enzyme inhibitor, enalapril, on albuminuria and renal function in relationship to clinic and ambulatory blood pressure (ABP) in hypertensive type 2 diabetic subjects with early nephropathy."5.09Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy. ( Bélanger, A; Godin, C; Hallé, JP; Lacourcière, Y; Marion, J; Ross, S; Wright, N, 2000)
"Numerous experimental and clinical studies suggest that uric acid might have pathobiologic implications in the development and progression of hypertension, kidney disease, and coronary heart disease, among others, resulting in renewed interest in uric acid as a potential pathogenic mediator in these clinical conditions."4.90Allopurinol as a kidney-protective, cardioprotective, and antihypertensive agent: hype or reality? ( Gaipov, A; Kanbay, M; Solak, Y; Takir, M; Weiner, DE, 2014)
"The influence of serum urate on kidney disease is attracting attention, but the effects of uric acid (UA) on nephrosclerosis have not been elucidated."3.85Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis. ( Kataoka, H; Mochizuki, T; Momoki, K; Moriyama, T; Nitta, K, 2017)
"As oxonic acid diet increased plasma renin activity, plasma aldosterone, and urine K to Na ratio, these changes may play a significant role in the harmful cardiovascular actions of hyperuricemia."3.74Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. ( Eräranta, A; Kööbi, P; Kurra, V; Lakkisto, P; Mustonen, JT; Niemelä, OJ; Pörsti, IH; Tahvanainen, AM; Tikkanen, I; Vehmas, TI, 2008)
"Serum uric acid independently predicted blunted renal vascular responsiveness to Ang II, consistent with results from experimental hyperuricemia showing an activated intrarenal RAS."3.72Uric acid and the state of the intrarenal renin-angiotensin system in humans. ( Brown, NJ; Fisher, ND; Gumieniak, O; Hollenberg, NK; Hopkins, PN; Murphey, LJ; Perlstein, TS; Williams, GH, 2004)
"To study whether the renin-angiotensin system is related to hyperuricemia in hypertension, the serum concentration of uric acid was determined in 96 patients with various types of hypertension and various degrees of plasma renin activity (PRA)."3.66Serum uric acid and the renin-angiotensin system in hypertension. ( Kato, E; Kondo, K; Nakamura, R; Oguro, T; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978)
"Uric acid stone formers were older, heavier and with higher triglycerides and uric acid plasma levels than calcium or struvite patients."2.68Hypertension in kidney stone patients. ( Barsotti, G; Cozza, V; Cupisti, A; Meola, M; Morelli, E; Parrucci, M, 1996)
"Hyperuricemia is an important predictor for poor prognosis in patients with LN."1.43Hyperuricemia is an independent risk factor for 
renal pathological damage and poor prognosis in 
lupus nephritis patients. ( Chen, M; Li, G; Li, J; Tang, X; Wang, X; Xie, T; Yin, H; Zhang, W; Zuo, X, 2016)
"Metabolic syndrome was induced in rats over 8 wk by either a high-fructose diet (60%, F60, n = 7) or by adding fructose to drinking water (10%, F10, n = 7)."1.34Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. ( Avila-Casado, C; Bautista, P; Cristóbal, M; Franco, M; Herrera-Acosta, J; Jiménez, A; Johnson, RJ; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007)
"When nitrendipine was combined with thiazides, a lowering of plasma potassium levels could be found, which, however, did not necessitate any therapy."1.27Safety aspects of long-term nitrendipine therapy. ( Corsing, C; Deck, K; Ingram, C; Stoepel, K; Vanov, SK, 1984)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199040 (57.14)18.7374
1990's9 (12.86)18.2507
2000's13 (18.57)29.6817
2010's8 (11.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kanbay, M2
Solak, Y2
Gaipov, A1
Takir, M1
Weiner, DE1
Uchida, S1
Takahashi, M1
Sugawara, M1
Saito, T1
Nakai, K1
Fujita, M1
Mochizuki, K1
Shin, I1
Morita, T1
Hikita, T1
Itakura, H1
Takahashi, Y2
Mizuno, S1
Ohno, Y1
Ito, K1
Ito, T1
Soma, M1
Kuriyama, S1
Maruyama, Y1
Nishio, S1
Kidoguchi, S1
Kobayashi, C1
Takahashi, D1
Sugano, N1
Hosoya, T1
Yokoo, T1
Fu, QY1
Ma, L1
Li, CC1
He, FG1
He, ZJ1
Zhang, WS1
Zhang, ZH1
Momoki, K1
Kataoka, H1
Moriyama, T1
Mochizuki, T1
Nitta, K1
Xie, T1
Chen, M1
Tang, X1
Yin, H1
Wang, X1
Li, G1
Li, J1
Zuo, X1
Zhang, W2
Eräranta, A1
Kurra, V1
Tahvanainen, AM1
Vehmas, TI1
Kööbi, P1
Lakkisto, P1
Tikkanen, I1
Niemelä, OJ1
Mustonen, JT1
Pörsti, IH1
Wang, Y1
Wang, Z1
Wang, W1
Ren, H1
Chen, N1
Yilmaz, MI1
Sonmez, A1
Saglam, M1
Cakir, E1
Unal, HU1
Arslan, E1
Verim, S1
Madero, M1
Caglar, K1
Oguz, Y1
McFann, K1
Johnson, RJ5
De Leeuw, PW1
Thijs, L1
Birkenhäger, WH1
Voyaki, SM1
Efstratopoulos, AD1
Fagard, RH1
Leonetti, G2
Nachev, C1
Petrie, JC1
Rodicio, JL1
Rosenfeld, JJ1
Sarti, C1
Staessen, JA1
Sánchez-Lozada, LG3
Tapia, E3
Avila-Casado, C3
Soto, V3
Franco, M3
Santamaría, J1
Nakagawa, T2
Rodríguez-Iturbe, B1
Herrera-Acosta, J2
SMYTHE, CM1
BRADHAM, WS1
DENNIS, EJ1
MCIVER, FA1
HOWE, HG1
RICHET, G1
MIGNON, F1
ARDAILLOU, R1
MAHER, JF1
FREEMAN, RB1
SCHREINER, GE1
BRECKENRIDGE, A1
METCALFE-GIBSON, A1
Høieggen, A1
Alderman, MH1
Kjeldsen, SE1
Julius, S1
Devereux, RB1
De Faire, U1
Fyhrquist, F1
Ibsen, H1
Kristianson, K1
Lederballe-Pedersen, O1
Lindholm, LH1
Nieminen, MS1
Omvik, P1
Oparil, S1
Wedel, H1
Chen, C1
Dahlöf, B1
Perlstein, TS1
Gumieniak, O1
Hopkins, PN1
Murphey, LJ1
Brown, NJ1
Williams, GH1
Hollenberg, NK1
Fisher, ND1
Daskalopoulou, SS1
Athyros, VG1
Elisaf, M1
Mikhailidis, D1
Jiménez, A1
Bautista, P1
Cristóbal, M1
Nepomuceno, T1
Zhao, L1
de Boer, MP1
Ijzerman, RG1
de Jongh, RT1
Eringa, EC1
Stehouwer, CD1
Smulders, YM1
Serné, EH1
Posey, RE1
Ritchie, EB1
Stoepel, K1
Deck, K1
Corsing, C1
Ingram, C1
Vanov, SK1
Guidi, E1
Magni, M1
di Belgiojoso, GB1
Minetti, L1
Bianchi, G1
Amery, A1
Birkenhäger, W1
Bogaert, M1
Brixko, P1
Bulpitt, C1
Clement, D1
De Leeuw, P1
De Plaen, JF1
Deruyttere, M1
De Schaepdryver, A1
Fagard, R1
Forette, F1
Forte, J1
Hamdy, R1
Hellemans, J1
Henry, JF1
Koistinen, A1
Laaser, U1
Laher, M1
Lewis, P1
Lund-Johansen, P1
MacFarlane, J1
Meurer, K1
Miguel, P1
Morris, J1
Mutsers, A1
Nissinen, A1
O'Brien, E1
Ohm, OJ1
O'Malley, K1
Pelemans, W1
Perera, N1
Tuomilehto, J1
Verschueren, LJ1
Willemse, P1
Williams, B1
Zanchetti, A1
Gansevoort, RT1
de Zeeuw, D1
Shahinfar, S1
Redfield, A1
de Jong, PE1
Chen, CY1
Chen, CS1
Georgadze, ZO1
Balabolkin, MI1
Mamaeva, GG1
Liudina, LI1
Mishchenko, BP1
Arbuzova, MI1
Cupisti, A1
Morelli, E1
Meola, M1
Cozza, V1
Parrucci, M1
Barsotti, G1
Smolarczyk, R1
Wójcicka-Jagodzińska, J1
Romejko, E1
Czajkowski, K1
Piekarski, P1
Teliga-Czajkowska, J1
Kuczyńcka-Sicińska, J1
Mukhin, NA2
Balkarov, IM2
Britov, AN1
Eliseeva, NA1
Bugaeva, NV1
Sura, VV1
Lebedeva, MV2
Kozlova, VG1
Degtiarev, VA1
Shonichev, DG2
Paramonov, AD1
Stavrou, C1
Pierides, A1
Zouvani, I1
Kyriacou, K1
Antignac, C1
Neophytou, P1
Christodoulou, K1
Deltas, CC1
Lacourcière, Y1
Bélanger, A1
Godin, C1
Hallé, JP1
Ross, S1
Wright, N1
Marion, J1
Ruilope, LM1
Garcia-Puig, J1
Mazzali, M1
Hughes, J1
Kim, YG1
Jefferson, JA1
Kang, DH1
Gordon, KL1
Lan, HY1
Kivlighn, S1
Mertz, DP3
Hohneck, A1
Lynch, RE1
Kjellstrand, CM1
Coccia, PF1
Schneider, H1
Streicher, E1
Hachmann, H1
Chmiel, H1
von Mylius, U1
Saito, I1
Saruta, T1
Kondo, K1
Nakamura, R1
Oguro, T1
Yamagami, K1
Ozawa, Y1
Kato, E1
Kawenoki-Minc, E1
Eyman, E1
Abgarowicz, T1
Brzozowska-Jurkowska, M1
Weryńska-Przybylska, J1
Bec, Ph1
Pujo, JM1
Suc, JM1
Martin, RL1
Möhring, J1
Petri, M1
Szokol, M1
Haack, D1
Möhring, B1
Zawadzki, J1
Januszewicz, P1
Maynard, J1
Benson, P1
Fine, RN1
De Palma, JR1
Lieberman, E1
Donnell, GN1
Gordon, A1
Maxwell, MH1
Cottier, P1
Wessels, F1
Heinze, A1
Oberwittler, W1
Losse, H1
Garrick, R1
Ewan, CE1
Bauer, GE1
Neale, FC1
Rieselbach, RE1
Steele, TH1
Armbruster, KF1
Ing, TS1
Kark, RM1
Overturf, M1
Fitz, A1
McBride, J1
Soballa, G1
Schewitz, LJ1
Anderson, J1
Godfrey, BE1
Hill, DM1
Munro-Faure, AD1
Sheldon, J1
Tibblin, G1
Levi, J1
Bicher, HI1
Rosenfeld, J1
Kiely, JM1
Wagoner, RD1
Holley, KE1
Cagli, V1
Ruotolo, V1
Bossini, A1
Bologna, E1
Van Goor, W1
Kooiker, CJ1
Mees, EJ1
Henninges, D1
Rastogi, SP1
Volans, G1
Elliott, RW1
Eccleston, DW1
Ashcroft, R1
Webster, D1
Kerr, DN1
Remenchik, AP1
Hoover, CR1
Brynjolfsson, G1
Hampers, CL1
Bailey, GL1
Hager, EB1
Vandam, LD1
Merrill, JP1
Simon, NM1
Smucker, JE1
O'Conor, VJ1
del Greco, F1
Cannon, PJ1
Stason, WB1
Demartini, FE1
Sommers, SC1
Laragh, JH1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Value of Uric Acid as Early Predictor of Lupus Nephritis in Assiut University Hospital[NCT05402735]100 participants (Anticipated)Observational2022-06-15Recruiting
A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients With Left Ventricular Hypertrophy[NCT00338260]Phase 3496 participants (Actual)Interventional1995-06-30Completed
Pediatric Hypertension Registry (PHREG)[NCT03305562]179 participants (Actual)Observational [Patient Registry]2017-09-20Terminated (stopped due to Study was a pilot study and the investigators received funding to initiate the main study)
The Role of the Renin-Angiotensin System in Pediatric Primary Hypertension (PHRAS)[NCT03310684]160 participants (Anticipated)Observational2018-12-03Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for uric acid and Hypertension, Renal

ArticleYear
Allopurinol as a kidney-protective, cardioprotective, and antihypertensive agent: hype or reality?
    Blood purification, 2014, Volume: 37, Issue:3

    Topics: Allopurinol; Antihypertensive Agents; Cardiotonic Agents; Chronic Disease; Coronary Disease; Gout Su

2014
[Development of arterial hypertension in urate tubulointerstitial renal damage].
    Terapevticheskii arkhiv, 1999, Volume: 71, Issue:6

    Topics: Acetylglucosaminidase; Adolescent; Adult; Biomarkers; Biopsy; Blood Pressure; Cytokines; Female; Hum

1999
Hyperuricemia and renal function.
    Current hypertension reports, 2001, Volume: 3, Issue:3

    Topics: Cardiovascular Diseases; Humans; Hypertension, Renal; Kidney; Renal Insufficiency; Uric Acid

2001
Renal and metabolic complications of childhood non-Hodgkin's lymphoma.
    Seminars in oncology, 1977, Volume: 4, Issue:3

    Topics: Acidosis; Acute Kidney Injury; Allopurinol; Aluminum Hydroxide; Burkitt Lymphoma; Child; Humans; Hyp

1977
[Disorders of tubular transport of uric acid leading to hyperuricemia].
    Polskie Archiwum Medycyny Wewnetrznej, 1992, Volume: 88, Issue:1

    Topics: Adult; Child; Circadian Rhythm; Female; Glomerular Filtration Rate; Humans; Hypertension, Renal; Kid

1992
Influence of the kidney upon urate homeostasis in health and disease.
    The American journal of medicine, 1974, Volume: 56, Issue:5

    Topics: Acute Kidney Injury; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Hypertension; Hy

1974
Hypertension and renal disease in pregnancy.
    The Medical clinics of North America, 1971, Volume: 55, Issue:1

    Topics: Adrenal Cortex Hormones; Animals; Biopsy; Body Weight; Diet, Sodium-Restricted; Eclampsia; Edema; Fe

1971

Trials

9 trials available for uric acid and Hypertension, Renal

ArticleYear
Effects of the N/L-type calcium channel blocker cilnidipine on nephropathy and uric acid metabolism in hypertensive patients with chronic kidney disease (J-CIRCLE study).
    Journal of clinical hypertension (Greenwich, Conn.), 2014, Volume: 16, Issue:10

    Topics: Aged; Aged, 80 and over; Albuminuria; Amlodipine; Blood Pressure; Calcium Channel Blockers; Creatini

2014
Prognostic significance of renal function in elderly patients with isolated systolic hypertension: results from the Syst-Eur trial.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:9

    Topics: Aged; Antihypertensive Agents; Creatinine; Double-Blind Method; Female; Glomerular Filtration Rate;

2002
The impact of serum uric acid on cardiovascular outcomes in the LIFE study.
    Kidney international, 2004, Volume: 65, Issue:3

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Cardiovascular Diseases; Creatinine; End

2004
Antihypertensive therapy in patients above age 60 with systolic hypertension. A progress report of the European Working Party on High Blood Pressure in the Elderly (EWPHE).
    Clinical and experimental hypertension. Part A, Theory and practice, 1982, Volume: 4, Issue:7

    Topics: Aged; Blood Glucose; Blood Pressure; Creatinine; Drug Therapy, Combination; Electrolytes; Female; Hu

1982
Effects of the angiotensin II antagonist losartan in hypertensive patients with renal disease.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1994, Volume: 12, Issue:2

    Topics: Albuminuria; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Gl

1994
Hypertension in kidney stone patients.
    Nephron, 1996, Volume: 73, Issue:4

    Topics: Adult; Aged; Calcium; Female; Humans; Hypertension, Renal; Kidney Calculi; Magnesium Compounds; Male

1996
[Evaluation of fetal condition in pregnancy complicated by hypertension--biochemical assessment of amniotic fluid. I. Protein and lipid components and kidney maturation].
    Ginekologia polska, 1996, Volume: 67, Issue:12

    Topics: Adult; Albumins; Amniotic Fluid; Cholesterol; Creatinine; Female; Humans; Hypertension; Hypertension

1996
Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy.
    Kidney international, 2000, Volume: 58, Issue:2

    Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neph

2000
A comparison of the effects of hydrochlorothiazide and of frusemide in the treatment of hypertensive patients.
    The Quarterly journal of medicine, 1971, Volume: 40, Issue:160

    Topics: Adult; Aged; Blood Pressure; Blood Proteins; Carbon Dioxide; Clinical Trials as Topic; Female; Furos

1971

Other Studies

54 other studies available for uric acid and Hypertension, Renal

ArticleYear
Serum uric acid and the incidence of CKD and hypertension.
    Clinical and experimental nephrology, 2015, Volume: 19, Issue:6

    Topics: Adult; Body Mass Index; Cholesterol, HDL; Cohort Studies; Female; Glomerular Filtration Rate; Humans

2015
Clinical Characteristics and Renal Histology in Pediatric Patients with Hypertension and Prehypertension Secondary to IgA Nephropathy.
    Nephron, 2016, Volume: 132, Issue:3

    Topics: Adolescent; Age Factors; Blood Pressure; Child; Child, Preschool; Female; Glomerular Filtration Rate

2016
Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis.
    Journal of atherosclerosis and thrombosis, 2017, Jun-01, Volume: 24, Issue:6

    Topics: Adolescent; Adult; Aged; Biomarkers; Biopsy; Cohort Studies; Comorbidity; Disease Progression; Femal

2017
Hyperuricemia is an independent risk factor for 
renal pathological damage and poor prognosis in 
lupus nephritis patients.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2016, Oct-28, Volume: 41, Issue:10

    Topics: Blood Urea Nitrogen; Creatinine; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertens

2016
Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency.
    Journal of hypertension, 2008, Volume: 26, Issue:8

    Topics: Aldosterone; Animal Feed; Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Hyperten

2008
Analysis of factors associated with renal function in Chinese adults with congenital solitary kidney.
    Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:20

    Topics: Adult; Biomarkers; Creatinine; Disease Progression; Female; Glomerular Filtration Rate; Humans; Hype

2010
Serum uric acid independently predicts cardiovascular events in advanced nephropathy.
    American journal of nephrology, 2012, Volume: 36, Issue:4

    Topics: Adult; Aged; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Female;

2012
Mild hyperuricemia induces glomerular hypertension in normal rats.
    American journal of physiology. Renal physiology, 2002, Volume: 283, Issue:5

    Topics: Animals; Arterioles; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Hypertrophy; Kidne

2002
RENAL ARTERIOLAR DISEASE IN YOUNG PRIMIPARAS.
    The Journal of laboratory and clinical medicine, 1964, Volume: 63

    Topics: Adolescent; Arteries; Black People; Blood Chemical Analysis; Body Weight; Eclampsia; Female; Humans;

1964
[SECONDARY GOUT IN CHRONIC NEPHROPATHIES].
    La Presse medicale, 1965, Mar-06, Volume: 73

    Topics: Amyloidosis; Blood; Colchicine; Drug Therapy; Gout; Humans; Hypertension; Hypertension, Renal; Kidne

1965
HEMODIALYSIS FOR CHRONIC RENAL FAILURE. II. BIOCHEMICAL AND CLINICAL ASPECTS.
    Annals of internal medicine, 1965, Volume: 62

    Topics: Anemia; Biochemical Phenomena; Biochemistry; Blood; Blood Pressure; Blood Urea Nitrogen; Calcium; Ch

1965
METHODS OF MEASURING GLOMERULAR-FILTRATION RATE: A COMPARISON OF INULIN, VITAMIN-B 12 AND CREATININE CLEARANCES.
    Lancet (London, England), 1965, Aug-07, Volume: 2, Issue:7406

    Topics: Cobalt Isotopes; Creatine; Creatinine; Diagnosis; Glomerular Filtration Rate; Gout; Humans; Hyperten

1965
Uric acid and the state of the intrarenal renin-angiotensin system in humans.
    Kidney international, 2004, Volume: 66, Issue:4

    Topics: Adult; Angiotensin II; Blood Pressure; Female; Humans; Hypertension, Renal; Hyperuricemia; Kidney; M

2004
The impact of serum uric acid on cardiovascular outcomes in the LIFE study.
    Kidney international, 2004, Volume: 66, Issue:4

    Topics: Antihypertensive Agents; Cardiovascular Diseases; Humans; Hypertension, Renal; Losartan; Uric Acid

2004
[Arterial hypertension in clinical assessment of ischemic renal disease].
    Terapevticheskii arkhiv, 2005, Volume: 77, Issue:6

    Topics: Aged; Aged, 80 and over; Blood Pressure; Cholesterol; Circadian Rhythm; Female; Humans; Hypertension

2005
Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:1

    Topics: Animals; Body Weight; Capillaries; Drinking; Eating; Fructose; Hypertension, Renal; Kidney; Kidney G

2007
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:4

    Topics: Animals; Blood Pressure; Febuxostat; Follow-Up Studies; Gout Suppressants; Hypertension, Renal; Hype

2008
Birth weight relates to salt sensitivity of blood pressure in healthy adults.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:4

    Topics: Adult; Blood Pressure; Creatinine; Female; Humans; Hypertension, Renal; Infant, Low Birth Weight; In

2008
Metastatic calcinosis cutis with renal hyperparathyroidism.
    Archives of dermatology, 1967, Volume: 95, Issue:5

    Topics: Adult; Blood Chemical Analysis; Calcinosis; Female; Humans; Hyperparathyroidism; Hypertension, Renal

1967
Safety aspects of long-term nitrendipine therapy.
    Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 7

    Topics: Calcium Channel Blockers; Drug Therapy, Combination; Electrocardiography; Humans; Hydrochlorothiazid

1984
Blood pressure in patients with four different primary glomerulopathies.
    Clinical and experimental hypertension. Part A, Theory and practice, 1984, Volume: 6, Issue:7

    Topics: Adult; Blood Pressure; Female; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Humans; Hype

1984
Stereoselective disposition of ibuprofen in patients with compromised renal haemodynamics.
    British journal of clinical pharmacology, 1995, Volume: 40, Issue:1

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Coronary Disease; Diabetes Mellitus; Female; Heart Fa

1995
[Kidney lesions in non-insulin dependent diabetes mellitus].
    Klinicheskaia meditsina, 1995, Volume: 73, Issue:6

    Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; G

1995
[The population aspects of renal arterial hypertension].
    Terapevticheskii arkhiv, 1997, Volume: 69, Issue:8

    Topics: Adult; Humans; Hypertension, Renal; Nephritis, Interstitial; Nephrosclerosis; Risk Factors; Uric Aci

1997
Medullary cystic kidney disease with hyperuricemia and gout in a large Cypriot family: no allelism with nephronophthisis type 1.
    American journal of medical genetics, 1998, May-01, Volume: 77, Issue:2

    Topics: Adult; Age of Onset; Aged; Cyprus; Female; Genes, Dominant; Genetic Linkage; Gout; Humans; Hypertens

1998
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Animals; Blood Pressure; Crystallization; Fibrosis; Hypertension, Renal; Kidney; Kidney Diseases; Ma

2001
[Frequency and distribution of types of hyperlipoproteinemia with life-shortening risk factors among ambulant patients (author's transl)].
    Medizinische Klinik, 1975, Jul-11, Volume: 70, Issue:28-29

    Topics: Cholesterol; Diabetes Complications; Female; Germany, West; Gout; Humans; Hyperlipidemias; Hypertens

1975
Clinical experience with haemofiltration.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1977, Volume: 14

    Topics: Blood Urea Nitrogen; Creatinine; Female; Humans; Hyperlipidemias; Hypertension, Renal; Male; Membran

1977
Serum uric acid and the renin-angiotensin system in hypertension.
    Journal of the American Geriatrics Society, 1978, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Aged; Angiotensin II; Child; Creatinine; Extracellular Space; Female; Furosemide;

1978
[Various aspects of nephropathy in gout].
    Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1978, Volume: 5

    Topics: Adult; Age Factors; Aged; Amyloidosis; Glomerular Filtration Rate; Gout; Humans; Hypertension, Renal

1978
[Definition and treatment requirements of uricemia].
    Fortschritte der Medizin, 1977, Jan-06, Volume: 95, Issue:1

    Topics: Adult; Aged; Chronic Disease; Diabetes Mellitus; Female; Gout; Humans; Hypertension, Renal; Liver Di

1977
[Mechanisms of action of benzbromarone. Study in 3 anephric subjects. Preliminary results in 3 cases].
    Semaine des hopitaux. Therapeutique, 1977, Volume: 53, Issue:4

    Topics: Adult; Benzbromarone; Benzofurans; Glomerulonephritis; Humans; Hypertension, Renal; Kidney Failure,

1977
Hypertension in pregnancy: normal and abnormal renal function.
    The Journal of the American Osteopathic Association, 1975, Volume: 74, Issue:6

    Topics: Blood Urea Nitrogen; Creatinine; Female; Humans; Hypertension; Hypertension, Renal; Kidney; Pregnanc

1975
Effects of saline drinking on malignant course of renal hypertension in rats.
    The American journal of physiology, 1976, Volume: 230, Issue:3

    Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Diet; Hematocrit; Hypertension, Malignant; Hyp

1976
Hereditary xanthinuria in 2 Pakistani sisters: asymptomatic in one with beta-thalassemia but causing xanthine stone, obstructive uropathy and hypertension in the other.
    The Journal of urology, 1988, Volume: 139, Issue:2

    Topics: Child, Preschool; Female; Humans; Hydronephrosis; Hypertension, Renal; Hypoxanthine; Hypoxanthines;

1988
Extended hemodialysis in children with chronic renal failure.
    The Journal of pediatrics, 1968, Volume: 73, Issue:5

    Topics: Adolescent; Anemia; Blood Flow Velocity; Blood Urea Nitrogen; Body Weight; Calcinosis; Calcium; Chil

1968
[Clarification of a hypertension].
    Schweizerische medizinische Wochenschrift, 1970, Sep-12, Volume: 100, Issue:37

    Topics: Aldosterone; Angiotensin II; Aortic Coarctation; Blood Pressure Determination; Creatinine; Cushing S

1970
Medical Grand Rounds from the University of Alabama Medical Center. Lead poisoning.
    Southern medical journal, 1972, Volume: 65, Issue:3

    Topics: Adult; Aged; Alcoholism; Amyotrophic Lateral Sclerosis; Anemia, Macrocytic; Brain Diseases; Diagnosi

1972
[The genesis of hyperuricemia in patients with essential hypertension (author's transl)].
    Medizinische Klinik, 1974, Apr-05, Volume: 69, Issue:14

    Topics: Adult; Angiotensin II; Biological Transport; Blood Pressure; Body Weight; Creatinine; Electrolytes;

1974
Serum uric acid in normal and hypertensive Australian subjects.
    Australian and New Zealand journal of medicine, 1972, Volume: 2, Issue:4

    Topics: Adolescent; Adult; Age Factors; Australia; Child; Colorimetry; Debrisoquin; Female; Guanethidine; Hu

1972
[Dialysis-free treatment of chronic kidney insufficiency].
    Der Internist, 1974, Volume: 15, Issue:2

    Topics: Acidosis, Renal Tubular; Anemia; Anuria; Diet Therapy; Dietary Proteins; Drinking; Heart Diseases; H

1974
Renin activity, sodium and potassium in hypertensive patients.
    Journal of chronic diseases, 1972, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Urea Nitrogen; Carbon Dioxide

1972
[Arterial hypertension. Diagnosis and therapy in practice].
    Fortschritte der Medizin, 1974, Feb-07, Volume: 92, Issue:4

    Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Electrocardiography; Exercise Ther

1974
High blood pressure in men aged 50--a population study of men born in 1913.
    Acta medica Scandinavica. Supplementum, 1967, Volume: 470

    Topics: Blood Glucose; Blood Pressure Determination; Blood Sedimentation; Blood Volume; Communicable Disease

1967
Platelet aggregation in several cardiovascular diseases determined with a modified screen filtration pressure method.
    Journal of medicine, 1970, Volume: 1, Issue:3

    Topics: Adenine Nucleotides; Adolescent; Adult; Blood Platelets; Cardiovascular Diseases; Cell Aggregation;

1970
Renal complications of lymphoma.
    Annals of internal medicine, 1969, Volume: 71, Issue:6

    Topics: Adult; Aged; Amyloidosis; Female; Humans; Hydronephrosis; Hypercalcemia; Hypertension, Renal; Kidney

1969
[Renal excretion of uric acid in various conditions inducing hyperuricemia].
    Il Policlinico. Sezione pratica, 1970, Feb-23, Volume: 77, Issue:8

    Topics: Adolescent; Adult; Aged; Female; Gout; Humans; Hydrochlorothiazide; Hypertension, Renal; Kidney Fail

1970
An unusual form of renal disease associated with gout and hypertension.
    Journal of clinical pathology, 1971, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Aged; Biopsy; Cerebrovascular Disorders; Chromosome Aberrations; Chromosome Disor

1971
[Gout in young patients].
    Les Cahiers de medecine, 1971, May-15, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Age Factors; Diabetes Complications; Fatty Liver; Gout; Humans; Hyperlipidemias;

1971
High dose frusemide in the treatment of hypertension in chronic renal insufficiency and of terminal renal failure.
    Postgraduate medical journal, 1971, Volume: 47

    Topics: Adolescent; Adult; Creatine; Creatinine; Diuresis; Female; Furosemide; Gout; Humans; Hypertension, R

1971
Adenine nucleotide levels of erythrocytes from exercised hypertensive rats.
    Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 19, Issue:2

    Topics: Adenine Nucleotides; Animals; Blood Pressure; Body Weight; Electrolytes; Erythrocytes; Female; Hemat

1968
Major surgery in patients on maintenance hemodialysis.
    American journal of surgery, 1968, Volume: 115, Issue:6

    Topics: Adolescent; Adult; Electrocardiography; Humans; Hypertension, Renal; Kidney Failure, Chronic; Middle

1968
Differential uric acid excretion in essential and renal hypertension.
    Circulation, 1969, Volume: 39, Issue:1

    Topics: Atrophy; Glomerular Filtration Rate; Humans; Hydronephrosis; Hypertension; Hypertension, Renal; Kidn

1969
Hyperuricemia in primary and renal hypertension.
    The New England journal of medicine, 1966, Sep-01, Volume: 275, Issue:9

    Topics: Adolescent; Adult; Aged; Blood Urea Nitrogen; Female; Glomerular Filtration Rate; Humans; Hyperchole

1966