Page last updated: 2024-10-20

uric acid and Hyperkalemia

uric acid has been researched along with Hyperkalemia in 46 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"The present review summarizes findings of recent studies examining the epidemiology, pathophysiology, and treatment of type 4 renal tubular acidosis (RTA) and uric acid nephrolithiasis, two conditions characterized by an abnormally acidic urine."9.41Type 4 renal tubular acidosis and uric acid nephrolithiasis: two faces of the same coin? ( Adomako, EA; Maalouf, NM, 2023)
"We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin."7.66Indomethacin-induced hyperkalemia in three patients with gouty arthritis. ( Beckstrom, D; Findling, JW; Itskovitz, H; Kozin, F; Rawsthorne, L, 1980)
"Ten patients with ascites due to chronic liver disease were treated with spironolactone as the sole diuretic in doses of 300 to 600 mg daily."7.66Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites. ( Campra, JL; Reynolds, TB, 1978)
"The present review summarizes findings of recent studies examining the epidemiology, pathophysiology, and treatment of type 4 renal tubular acidosis (RTA) and uric acid nephrolithiasis, two conditions characterized by an abnormally acidic urine."5.41Type 4 renal tubular acidosis and uric acid nephrolithiasis: two faces of the same coin? ( Adomako, EA; Maalouf, NM, 2023)
" The treatment consists in hydration, correction of the acidosis and hyperkalemia, use of allopurinol and recombinant urate oxidase (rasburicase) for preventing urate nephropathy and haemodialysis."4.84[The pathophysiology, clinical signs and therapy of urate nephropathy]. ( Méhes, L; Rejto, L; Szász, R; Udvardy, M, 2007)
"A 52-year-old man with retroperitoneal nodal, lung, and liver metastases from choriocarcinoma received chemotherapy with etoposide, cisplatin, and bleomycin."3.70Acute tumor lysis syndrome with choriocarcinoma. ( Blanke, CD; Hemmer, MP; Witte, RS, 2000)
"We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin."3.66Indomethacin-induced hyperkalemia in three patients with gouty arthritis. ( Beckstrom, D; Findling, JW; Itskovitz, H; Kozin, F; Rawsthorne, L, 1980)
"Ten patients with ascites due to chronic liver disease were treated with spironolactone as the sole diuretic in doses of 300 to 600 mg daily."3.66Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites. ( Campra, JL; Reynolds, TB, 1978)
"Individuals with cancer are subject to fluid and electrolyte imbalances because of the original disease process, therapy, and complications resulting from both the disease process and from therapy."2.36Fluid and electrolyte disturbances associated with cancer and its treatment. ( Cunningham, SG, 1982)
"Hyperkalemia is produced by redistribution of cellular and extracellular potassium or by increased body potassium."2.36Diagnostic strategies in disorders of fluid, electrolyte and acid-base homeostasis. ( Bastl, CP; Jones, ER; Narins, RG; Rudnick, MR; Stom, MC, 1982)
"The frequency and the severity of disseminated intravascular coagulation (DIC) and of metabolic complications during the induction treatment were studied in 62 cases of acute lymphocytic leukemia with initial white blood cell count over 100 000/cu mm."1.26[Acute lymphoblastic leukemia with hyperleucocytosis: an urgent problem during initial treatment (author's transl)]. ( Harousseau, JL; Jacquillat, C; Schaison, G; Tobelem, G, 1979)
"Twenty-one patients developed acute renal failure in association with nontraumatic rhabdomyolysis and myoglobinuria."1.26Acute renal failure due to nontraumatic rhabdomyolysis. ( Friedler, RM; Koffler, A; Massry, SG, 1976)
"A diagnosis of acute renal failure was established within 14 to 70 hours after hepatic artery ligation."1.26Acute renal failure after ligation of the hepatic artery. ( Carrillo, M; Fortner, JG; Kallum, B; Kim, DK; Penneman, R; Scheiner, E, 1976)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199036 (78.26)18.7374
1990's4 (8.70)18.2507
2000's3 (6.52)29.6817
2010's1 (2.17)24.3611
2020's2 (4.35)2.80

Authors

AuthorsStudies
Meremo, A1
Paget, G1
Duarte, R1
Dickens, C1
Dix-Peek, T1
Bintabara, D1
Naicker, S1
Adomako, EA1
Maalouf, NM1
Al Wakeel, JS1
Méhes, L1
Udvardy, M1
Szász, R1
Rejto, L1
Tomlinson, GC1
Solberg, LA1
Vogelzang, NJ1
Nelimark, RA1
Nath, KA1
Dutel, JL1
Voisin, P1
Brière, J1
Vogler, WR1
Morris, JG1
Winton, EF1
Grajek, S1
Páradowski, S1
Cieślicka, T1
Głuszek, J1
Wysocki, M1
Blok, W1
Konieczka, Z1
Cunningham, SG1
Narins, RG1
Jones, ER1
Stom, MC1
Rudnick, MR1
Bastl, CP1
Lichtman, MA1
Rowe, JM1
Schollmeyer, P1
Cohen, LF1
Balow, JE1
Magrath, IT1
Poplack, DG1
Ziegler, JL1
Findling, JW1
Beckstrom, D1
Rawsthorne, L1
Kozin, F1
Itskovitz, H1
Hande, KR1
Garrow, GC1
Joual, A1
Dakir, M1
el Mrini, M1
Benjelloun, S1
Donati-Genet, P1
Donati, R1
Colombo, JP1
Lüthy, CM1
Bianchetti, MG1
Blanke, CD1
Hemmer, MP1
Witte, RS1
Farley-Hills, E1
Byrne, AJ1
Brennan, L1
Sartori, P1
Campra, JL1
Reynolds, TB1
Wilson, D1
Stewart, A1
Szwed, J1
Einhorn, LH1
Harousseau, JL1
Tobelem, G1
Schaison, G2
Jacquillat, C1
Eisinger, RP1
Carlier, J1
Rorive, G1
Bovy, P1
Lamid, S1
Klingbeil, G1
Koffler, A1
Friedler, RM1
Massry, SG1
Kim, DK1
Penneman, R1
Kallum, B1
Carrillo, M1
Scheiner, E1
Fortner, JG1
Glezer, GA1
Morita, J1
Ito, Y1
Yoshino, M1
Koga, Y1
Yano, S1
Yoshida, I1
Yamashita, F1
Papademetriou, V1
Patterson, KL1
Klopovich, P1
Leonov, Y1
Golik, A1
Kaufman, S1
Gilboa, Y1
Fukuda, M1
Inaba, R1
Bokarev, IN1
Baranova, NV1
Madero López, L1
Muñoz Villa, A1
Gallego Cobos, N1
Onsurbe Ramírez, I1
Leverger, G1
Tourani, JM1
Beuzeboc, P1
Najarian, JS1
Fryd, DS1
Strand, M1
Canafax, DM1
Ascher, NL1
Payne, WD1
Simmons, RL1
Sutherland, DE1
Berlyne, GM1
Shaw, AB1
Nilwarangkur, S1
Armata, J1
Depowska, T1
Ueda, Y1
Ogura, Y1
Saito, A1
Yamamoto, M1
Kramer, HJ1
Krück, F1
Armbruster, KF1
Ing, TS1
Kark, RM1
Morse, BM1
Shattil, SJ1
Leiter, L1
Paterson, JW1
Dollery, CT1
Haslam, RM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia[NCT04744987]122 participants (Actual)Observational2019-07-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for uric acid and Hyperkalemia

ArticleYear
Type 4 renal tubular acidosis and uric acid nephrolithiasis: two faces of the same coin?
    Current opinion in nephrology and hypertension, 2023, Mar-01, Volume: 32, Issue:2

    Topics: Acidosis, Renal Tubular; Diabetes Mellitus, Type 2; Humans; Hydrogen-Ion Concentration; Hyperkalemia

2023
[The pathophysiology, clinical signs and therapy of urate nephropathy].
    Orvosi hetilap, 2007, Apr-22, Volume: 148, Issue:16

    Topics: Acidosis; Acute Kidney Injury; Allopurinol; Fluid Therapy; Humans; Hyperkalemia; Kidney Tubules; Rec

2007
Fluid and electrolyte disturbances associated with cancer and its treatment.
    The Nursing clinics of North America, 1982, Volume: 17, Issue:4

    Topics: Blood Volume; Body Water; Calcium; Humans; Hypercalcemia; Hyperkalemia; Hypocalcemia; Hypokalemia; I

1982
Diagnostic strategies in disorders of fluid, electrolyte and acid-base homeostasis.
    The American journal of medicine, 1982, Volume: 72, Issue:3

    Topics: Acid-Base Imbalance; Acidosis; Alkalosis; Bicarbonates; Calcium Metabolism Disorders; Humans; Hyperk

1982
Hyperleukocytic leukemias: rheological, clinical, and therapeutic considerations.
    Blood, 1982, Volume: 60, Issue:2

    Topics: Adolescent; Allopurinol; Antineoplastic Agents; Blood Flow Velocity; Blood Viscosity; Cerebrovascula

1982
Acute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphoma.
    The American journal of medicine, 1993, Volume: 94, Issue:2

    Topics: Acute Disease; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Blood Urea Nitrogen; Bur

1993
[Selection and administration of drugs on patients with chronic kidney failure].
    Nihon rinsho. Japanese journal of clinical medicine, 1972, Volume: 30, Issue:12

    Topics: Analgesics; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antihypertensive Agents; Barbiturates; Ca

1972
[Pharmacological bases of diuretic therapy. 2].
    Medizinische Klinik, 1974, Jan-18, Volume: 69, Issue:3

    Topics: Acidosis; Alkalosis; Digitalis Glycosides; Diuretics; Drug Synergism; Edema; Gastrointestinal Hemorr

1974
Combinations of diuretics in the treatment of edema.
    American heart journal, 1970, Volume: 80, Issue:3

    Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu

1970

Trials

2 trials available for uric acid and Hyperkalemia

ArticleYear
A single institution, randomized, prospective trial of cyclosporin versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients.
    Annals of surgery, 1985, Volume: 201, Issue:2

    Topics: Adolescent; Adult; Antilymphocyte Serum; Aspartate Aminotransferases; Azathioprine; Clinical Trials

1985
Amiloride hydrochloride in hypertensive patients.
    British medical journal, 1968, Feb-17, Volume: 1, Issue:5589

    Topics: Bicarbonates; Blood Pressure; Chlorides; Depression, Chemical; Diuretics; Drug Synergism; Guanidines

1968

Other Studies

35 other studies available for uric acid and Hyperkalemia

ArticleYear
Demographic and clinical profile of black patients with chronic kidney disease attending a tertiary hospital in Johannesburg, South Africa.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Acidosis; Aged; Allopurinol; Anemia; Bicarbonates; Cross-Sectional Studies; Diabetes Mellitus; Doxaz

2022
Kidney function and metabolic profile of chronic kidney disease and hemodialysis patients during Ramadan fasting.
    Iranian journal of kidney diseases, 2014, Volume: 8, Issue:4

    Topics: Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Body Weight; Creatinine; Erythrocyte Count; Fastin

2014
Acute tumor lysis syndrome with metastatic medulloblastoma. A case report.
    Cancer, 1984, Apr-15, Volume: 53, Issue:8

    Topics: Abdominal Neoplasms; Adult; Blood Urea Nitrogen; Female; Humans; Hyperkalemia; Hypocalcemia; Medullo

1984
Tumor lysis syndrome after induction chemotherapy of small-cell bronchogenic carcinoma.
    JAMA, 1983, Jan-28, Volume: 249, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Female; Humans; Hyperkalemia;

1983
[Acute anuric renal failure caused by hyperphosphoremia in acute lymphoblastic leukemia. 3 cases].
    La Revue de medecine interne, 1983, Volume: 4, Issue:3

    Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Agents; Female; Follow-Up Studies; Humans; Hy

1983
Acute tumor lysis in T-cell leukemia induced by amsacrine.
    Archives of internal medicine, 1983, Volume: 143, Issue:1

    Topics: Adolescent; Aminoacridines; Amsacrine; Bone Marrow; Humans; Hyperkalemia; Leukemia, Lymphoid; Male;

1983
[Arterial hypertension in men aged 40-59 years. IV. Relation between uric acid and potassium and creatinine concentrations in the serum of hyper- and normotensive persons].
    Kardiologia polska, 1983, Volume: 26, Issue:2

    Topics: Adult; Blood Pressure; Humans; Hyperkalemia; Hypertension; Male; Middle Aged; Potassium; Uric Acid

1983
[Interstitial nephritis in metabolic diseases].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1980, Volume: 86

    Topics: Amyloidosis; Glomerular Filtration Rate; Humans; Hypercalcemia; Hyperkalemia; Kidney Calculi; Metabo

1980
Acute tumor lysis syndrome. A review of 37 patients with Burkitt's lymphoma.
    The American journal of medicine, 1980, Volume: 68, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamid

1980
Indomethacin-induced hyperkalemia in three patients with gouty arthritis.
    JAMA, 1980, Sep-05, Volume: 244, Issue:10

    Topics: Acute Disease; Acute Kidney Injury; Aged; Diabetes Mellitus; Female; Gout; Humans; Hyperkalemia; Ind

1980
[Calculus-induced anuria. Apropos of 25 cases].
    Annales d'urologie, 1997, Volume: 31, Issue:4

    Topics: Acidosis; Adult; Age Factors; Aged; Aged, 80 and over; Anuria; Calcium; Cause of Death; Female; Foll

1997
Urinary sodium, potassium, chloride, calcium, magnesium, phosphate, urate and urea in healthy subjects aged 5-18 years.
    Nephron, 1998, Volume: 78, Issue:2

    Topics: Acidosis, Renal Tubular; Adolescent; Calcium; Child; Child, Preschool; Chlorides; Electrolytes; Fema

1998
Acute tumor lysis syndrome with choriocarcinoma.
    Southern medical journal, 2000, Volume: 93, Issue:9

    Topics: Acidosis; Acute Disease; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents,

2000
Tumour lysis syndrome during anaesthesia.
    Paediatric anaesthesia, 2001, Volume: 11, Issue:2

    Topics: Abdomen; Anesthesia; Biopsy; Child, Preschool; Female; Humans; Hyperkalemia; Hypocalcemia; Lymphoma,

2001
Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites.
    The American journal of digestive diseases, 1978, Volume: 23, Issue:11

    Topics: Adult; Ascites; Blood Urea Nitrogen; Creatinine; Drug Evaluation; Female; Hepatitis, Alcoholic; Huma

1978
Cardiac arrest due to hyperkalemia following therapy for acute lymphoblastic leukemia.
    Cancer, 1977, Volume: 39, Issue:5

    Topics: Adolescent; Allopurinol; Daunorubicin; Drug Therapy, Combination; Heart Arrest; Humans; Hyperkalemia

1977
[Acute lymphoblastic leukemia with hyperleucocytosis: an urgent problem during initial treatment (author's transl)].
    La Nouvelle presse medicale, 1979, May-19, Volume: 8, Issue:22

    Topics: Adolescent; Adult; Blood Glucose; Child; Child, Preschool; Disseminated Intravascular Coagulation; D

1979
Office management of chronic renal disease.
    American family physician, 1979, Volume: 20, Issue:1

    Topics: Animals; Calcium; Chronic Disease; Counseling; Dietary Proteins; Dogs; Humans; Hyperkalemia; Hyperte

1979
[Diuretics in cardiac insufficiency].
    Acta clinica Belgica, 1977, Volume: 32, Issue:3

    Topics: Alkalosis; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Diuretics; Diuretics, Osmotic; Heart Fa

1977
Hyperkalemia, hypercalcemia, and hyperuricemia after a diet with soup.
    The American journal of clinical nutrition, 1978, Volume: 31, Issue:12

    Topics: Diet, Reducing; Humans; Hypercalcemia; Hyperkalemia; Male; Middle Aged; Uric Acid; Vegetables

1978
Acute renal failure due to nontraumatic rhabdomyolysis.
    Annals of internal medicine, 1976, Volume: 85, Issue:1

    Topics: Acidosis; Acute Kidney Injury; Adult; Alcoholic Intoxication; Blood Urea Nitrogen; Calcium; Creatini

1976
Acute renal failure after ligation of the hepatic artery.
    Surgery, gynecology & obstetrics, 1976, Volume: 143, Issue:3

    Topics: Acute Kidney Injury; Adult; Aged; Aspartate Aminotransferases; Chemotherapy, Cancer, Regional Perfus

1976
[The side effects and complications in treatment with diuretic preparations. 2].
    Terapevticheskii arkhiv, 1992, Volume: 64, Issue:11

    Topics: Diuretics; Drug Hypersensitivity; Humans; Hypercalcemia; Hyperkalemia; Hypocalcemia; Hypokalemia; Ma

1992
Persistent hyperkalaemia in vitamin B12 unresponsive methylmalonic acidaemia.
    Journal of inherited metabolic disease, 1989, Volume: 12, Issue:1

    Topics: Child; Female; Glomerular Filtration Rate; Humans; Hyperaldosteronism; Hyperkalemia; Malonates; Meta

1989
Clinical significance of metabolic disturbances induced by the use of diuretics.
    Arquivos brasileiros de cardiologia, 1987, Volume: 49, Issue:6

    Topics: Arrhythmias, Cardiac; Blood Glucose; Cardiomegaly; Diuretics; Humans; Hyperkalemia; Lipids; Potassiu

1987
Metabolic emergencies in pediatric oncology: the acute tumor lysis syndrome.
    Journal of the Association of Pediatric Oncology Nurses, 1987, Volume: 4, Issue:3-4

    Topics: Child; Emergencies; Humans; Hyperkalemia; Hypocalcemia; Metabolic Diseases; Neoplasms; Phosphates; U

1987
Acute tumour lysis syndrome with extreme metabolic abnormalities.
    Clinical and laboratory haematology, 1987, Volume: 9, Issue:1

    Topics: Adult; Drug-Related Side Effects and Adverse Reactions; Humans; Hypercalcemia; Hyperkalemia; Hypocal

1987
[Tumor lysis syndrome, DIC and interstitial pneumonia after treatment with prednisolone and melphalan in a patient with acute monocytic leukemia with tumor formation].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1987, Volume: 28, Issue:4

    Topics: Blood Urea Nitrogen; Disseminated Intravascular Coagulation; Humans; Hyperkalemia; Leukemia, Monocyt

1987
[Complications of verospirone therapy].
    Klinicheskaia meditsina, 1987, Volume: 65, Issue:9

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Dyspepsia; Female; Gynecomastia; Humans;

1987
[Metabolic and renal changes in lymphoproliferative syndromes of childhood].
    Anales espanoles de pediatria, 1985, Volume: 22, Issue:2

    Topics: Acute Kidney Injury; Antineoplastic Agents; Child; Cyclophosphamide; Female; Humans; Hypercalcemia;

1985
[Acute hyperleukocytic lymphoblastic leukemia (greater than or equal to 100,000 leukocytes/mm3). Metabolic changes during induction treatment. Study, prevention and treatment].
    Archives francaises de pediatrie, 1985, Volume: 42, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Emergencies; Hemostasis; Humans; Hyperglycemia; Hyperkalemia; I

1985
Dietary treatment of chronic renal failure. Experiences with a modified Giovannetti diet.
    Nephron, 1965, Volume: 2, Issue:3

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Aged; Arteritis; Dietary Proteins; Edema; Female;

1965
[Hypocalcemia and hyperuricemia during treatment of acute lymphoblastic leukemia in childhood].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1974, Jul-29, Volume: 29, Issue:30

    Topics: Acute Disease; Allopurinol; Child, Preschool; Humans; Hyperkalemia; Hypocalcemia; Leukemia, Lymphoid

1974
[Dialysis-free treatment of chronic kidney insufficiency].
    Der Internist, 1974, Volume: 15, Issue:2

    Topics: Acidosis, Renal Tubular; Anemia; Anuria; Diet Therapy; Dietary Proteins; Drinking; Heart Diseases; H

1974
Metabolic complications of aggressive therapy of chronic lymphocytic leukemia.
    The American journal of the medical sciences, 1974, Volume: 267, Issue:5

    Topics: Animals; Blood Cell Count; Blood Platelets; Blood Urea Nitrogen; Calcium; Chlorambucil; Creatinine;

1974