Page last updated: 2024-10-20

uric acid and Hyperglycemia

uric acid has been researched along with Hyperglycemia in 122 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
"Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS)."7.83Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study. ( Eriksen, BO; Jenssen, TG; Norvik, JV; Solbu, MD; Storhaug, HM; Ytrehus, K; Zykova, SN, 2016)
" Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased."7.76Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010)
"Male and female, Sprague-Dawley rats, with and without arteriosclerosis, were subjected to chronic treatment with furosemide for 4 weeks."7.66Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats. ( Wexler, BC, 1981)
"The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension."7.66A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980)
"Hyperglycemia is a feature of worse brain injury after acute ischemic stroke, but the underlying metabolic changes and the link to cytotoxic brain injury are not fully understood."5.62Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke. ( Acharjee, A; Ament, Z; Bevers, MB; Kimberly, WT; Wolcott, Z, 2021)
"Hyperglycemia was induced by i."5.46Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice. ( Castellví, C; Chamorro, Á; Deddens, LH; Dijkhuizen, RM; Justicia, C; Pérez-de-Puig, I; Planas, AM; Salas-Perdomo, A; van Tilborg, GAF, 2017)
" Compared to nonadenomatous polyps, older age, higher 25(OH) vitamin D and higher uric acid levels were at increased risk for adenomatous polyps."4.31Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps. ( Chang, YJ; Chao, JN; Chiang, CH; He, SR; Liu, YT; Yang, CH, 2023)
"To explore whether dyslipidemia, hyperglycemia or hypertension has mediating effect on the association between serum uric acid (SUA) and the development of chronic kidney disease (CKD)."4.02The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis. ( Liu, L; Lv, X; Song, Y; Sun, H; Wang, S; Xu, L; Zhan, S, 2021)
"Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS)."3.83Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study. ( Eriksen, BO; Jenssen, TG; Norvik, JV; Solbu, MD; Storhaug, HM; Ytrehus, K; Zykova, SN, 2016)
"At high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease."3.81Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes. ( Gonzales, GF; Tapia, V, 2015)
" The higher CRP group was discriminated by the above variables in addition to lower VO(2max), serum metabolic syndrome components (triglycerides, glucose, and HDL cholesterol), higher insulin, homeostasis assessment of insulin resistance, uric acid, gamma-GT, and homocysteine."3.79Pathological and behavioral risk factors for higher serum C-reactive protein concentrations in free-living adults--a Brazilian community-based study. ( Burini, RC; de Oliveira, EP; Manda, RM; Michelin, E; Moreto, F; Teixeira, O; Torezan, GA, 2013)
" In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose."3.79A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress. ( Hong, E; Moreno, JA, 2013)
" Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased."3.76Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010)
" Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance."3.74Thiazide diuretics exacerbate fructose-induced metabolic syndrome. ( Johnson, RJ; Mu, W; Nakagawa, T; Reungjui, S; Roncal, CA; Sirivongs, D; Srinivas, TR, 2007)
" The diabetic dams presented hyperglycemia, hyperlipemia, hypertriglyceridemia, hypercholesterolemia, hyperuricemia, decreased reduced glutathione (GSH), hepatic glycogen and superoxide dismutase (SOD) determinations."3.71Oxidative stress and diabetes in pregnant rats. ( Cunha Rudge, MV; Damasceno, DC; de Mattos Paranhos Calderon, I; Volpato, GT, 2002)
" The high prevalence and severity of metabolic disturbances associated with the insulin resistance syndrome (hyperglycaemia, hyperinsulinaemia, decreased HDL cholesterol, hypertriglyceridaemia, elevated fibrinogen levels and hyperuricaemia) before gastroplasty were significantly decreased after weight loss."3.70Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity. ( Desaive, C; Dewe, W; Gielen, JE; Lefebvre, PJ; Luyckx, FH; Scheen, AJ, 1998)
"The aim of the present research was to compare the uric acid, sodium and potassium excretions among patients with mild preeclampsia and normotensive pregnancy and to determine their behavior towards an acute physiologic state of hyperglycemia-hyperinsulinemia."3.70[Excretion of uric aid, sodium, and potassium in preeclampsia patients and its behavior in acute hyperglycemia-hyperinsulinemia]. ( González-Ortiz, M; Grover-Páez, F; Martínez-Abundis, E; Vera-Hernández, A, 1999)
"Male and female, Sprague-Dawley rats, with and without arteriosclerosis, were subjected to chronic treatment with furosemide for 4 weeks."3.66Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats. ( Wexler, BC, 1981)
"The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension."3.66A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980)
"Healthy virgin and breeder rats (Sprague-Dawley) with naturally occurring hypertension and arteriosclerosis were fed 5% oxonic acid and 1% uric acid added to their regular diet for 30 days."3.65Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis. ( Greenberg, BP; Wexler, BC, 1977)
"Fourteen subjects with type 2 diabetes (aged 49·5 (sd 8·6) years, BMI 29·4 (sd 4·5) kg/m2, low habitual Ca consumption (<600 mg/d)) were included in this randomised, crossover clinical trial."2.90High calcium intake from fat-free milk, body composition and glycaemic control in adults with type 2 diabetes: a randomised crossover clinical trial. ( Alfenas, RCG; de Assis Costa, J; Gomes, JMG; Ribeiro, PVM, 2019)
"Insulin sensitivity was assessed by hyperinsulinaemic-euglycaemic clamps and cardiovascular variables were measured."2.84Comparison of the effects of diets high in animal or plant protein on metabolic and cardiovascular markers in type 2 diabetes: A randomized clinical trial. ( Hornemann, S; Markova, M; Pfeiffer, AFH; Pivovarova, O; Rohn, S; Rudovich, N; Schneeweiss, R; Sucher, S; Thomann, R, 2017)
"Soy protein with isoflavones or isoflavones alone at the provided dosage showed no significantly beneficial effects on measured cardiovascular risk factors in postmenopausal Chinese women with early hyperglycaemia."2.77The effects of isoflavones combined with soy protein on lipid profiles, C-reactive protein and cardiovascular risk among postmenopausal Chinese women. ( Chen, YM; Ho, SC; Ho, YP; Liu, ZM, 2012)
" Although there were no statistically significant differences among the 100-, 200-, and 300-mg treatment groups, there was a trend toward a dose-response relationship for most plasma glucose variables that were measured."2.68Reduction of glycosylated hemoglobin and postprandial hyperglycemia by acarbose in patients with NIDDM. A placebo-controlled dose-comparison study. ( Beisswenger, P; Coniff, RF; Kleinfield, R; McGill, JB; Robbins, D; Seaton, TB; Shapiro, JA, 1995)
"Treatment with empagliflozin resulted in a superior reduction in SUA (WMD -45."2.58Effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials. ( Chen, L; Tian, D; Wang, L; Xia, P; Xu, L; Zhao, Y; Zheng, H, 2018)
"Hyperuricemia and type 2 diabetes mellitus were inter-related, type 2 diabetes mellitus was more at risk of having a higher serum uric acid level, and also individuals with higher serum uric acid had higher risk of developing type 2 diabetes in the future."2.55Effects of Sodium Glucose Cotransporter-2 Inhibitors on Serum Uric Acid in Type 2 Diabetes Mellitus. ( Ahmadieh, H; Azar, S, 2017)
"Acute kidney injury is a frequent complication among ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI), and is associated with adverse outcomes."2.53Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: a multifactorial entity. ( Arbel, Y; Shacham, Y; Steinvil, A, 2016)
" This increased potency and the consequent decreased dose requirement give bumetanide the potential for increased effectiveness and decreased incidence of adverse effects."2.37Cellular mechanism of action of loop diuretics: implications for drug effectiveness and adverse effects. ( Feig, PU, 1986)
"Hyperglycemia is a feature of worse brain injury after acute ischemic stroke, but the underlying metabolic changes and the link to cytotoxic brain injury are not fully understood."1.62Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke. ( Acharjee, A; Ament, Z; Bevers, MB; Kimberly, WT; Wolcott, Z, 2021)
"Hyperuricemia has been recognized as a risk factor for insulin resistance as well as one of the factors leading to diabetic kidney disease (DKD)."1.51Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice. ( Asano, T; Fujishiro, M; Inoue, MK; Kikuchi, T; Kushiyama, A; Masaki, T; Matsunaga, Y; Mizuno, Y; Morii, K; Nakatsu, Y; Ono, H; Sakoda, H; Sasaki, K; Takahashi, M; Ueda, K; Yamamotoya, T, 2019)
"Hyperglycemia was induced by i."1.46Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice. ( Castellví, C; Chamorro, Á; Deddens, LH; Dijkhuizen, RM; Justicia, C; Pérez-de-Puig, I; Planas, AM; Salas-Perdomo, A; van Tilborg, GAF, 2017)
"Metabolic syndrome was found in 2502 of 18,222 healthy Chinese people (16."1.43Correlation of the leucocyte count with traditional and non-traditional components of metabolic syndrome. ( Gao, BL; Su, BY; Tian, CF; Tong, YH; Zhao, XH; Zheng, Y, 2016)
"123 participants who had NAFLD at baseline lost NAFLD during the 8-year follow-up period."1.43Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study. ( Chen, XH; Li, YL; Lu, ZY; Shao, Z; Wulasihan, M, 2016)
"Although increased susceptibility to infection has been observed in subjects with diabetes or obesity, little is known about the relationship between metabolic disorders and increased susceptibility to infection."1.36Association between capacity of interferon-alpha production and metabolic parameters. ( Fukui, M; Hasegawa, G; Nakamura, N; Nakumura, N; Tominaga, M; Uno, K; Yagi, K; Yoshikawa, T, 2010)
"The rates of progression to type 2 diabetes were lowest from the NGT subgroup, highest from the IGT group, with the PFH group in the middle, suggesting that PFH might be a transitional condition that precedes IGT and diabetes."1.30Progression to type 2 diabetes among high-risk groups in Kin-Chen, Kinmen. Exploring the natural history of type 2 diabetes. ( Chou, P; Li, CL; Tsai, ST; Wu, GS, 1998)
"The majority (72%) who progressed to NIDDM did so in year 1."1.29High risk of progression to NIDDM in South-African Indians with impaired glucose tolerance. ( Gouws, E; Motala, AA; Omar, MA, 1993)
"163 patients suffering from sudden hearing loss were examined with regard to their cardiovascular risk factors (hypertension, hyperlipaemia, cigarette smoking, hyperglycaemia, hyperuricaemia and obesity)."1.27[Etiology and pathogenesis of sudden deafness]. ( Friedrich, G, 1985)
"Obesity was found in 19 per cent of all patients and serum uric acid levels over 0."1.25Myocardial infarction in young men. Study of risk factors in nine countries. ( Dolder, MA; Oliver, MF, 1975)

Research

Studies (122)

TimeframeStudies, this research(%)All Research%
pre-199065 (53.28)18.7374
1990's13 (10.66)18.2507
2000's9 (7.38)29.6817
2010's29 (23.77)24.3611
2020's6 (4.92)2.80

Authors

AuthorsStudies
La Grotta, R1
de Candia, P1
Olivieri, F1
Matacchione, G1
Giuliani, A1
Rippo, MR1
Tagliabue, E1
Mancino, M1
Rispoli, F1
Ferroni, S1
Berra, CC1
Ceriello, A1
Prattichizzo, F1
Liu, T1
Song, J1
Zuo, R1
Sun, L1
Zhu, Z1
Wang, B1
Lu, Z1
Pan, Y1
Chiang, CH1
Chang, YJ1
He, SR1
Chao, JN1
Yang, CH1
Liu, YT1
Luo, Y1
Wu, Q1
Meng, R1
Lian, F1
Jiang, C1
Hu, M1
Wang, Y1
Ma, H1
Mizuno, Y1
Yamamotoya, T1
Nakatsu, Y1
Ueda, K1
Matsunaga, Y1
Inoue, MK1
Sakoda, H1
Fujishiro, M1
Ono, H1
Kikuchi, T1
Takahashi, M1
Morii, K1
Sasaki, K1
Masaki, T1
Asano, T1
Kushiyama, A1
Ament, Z1
Bevers, MB1
Wolcott, Z1
Kimberly, WT1
Acharjee, A1
Xu, L2
Sun, H1
Liu, L2
Zhan, S1
Wang, S1
Lv, X1
Song, Y1
Lytvyn, Y2
Har, R1
Locke, A1
Lai, V1
Fong, D1
Advani, A1
Perkins, BA2
Cherney, DZI1
Kawamoto, R1
Ninomiya, D1
Senzaki, K1
Kasai, Y1
Kusunoki, T1
Ohtsuka, N1
Kumagi, T1
Ahmadieh, H1
Azar, S1
Zhao, Y1
Tian, D1
Xia, P1
Zheng, H1
Wang, L1
Chen, L1
Ma, Y1
Cao, H1
Li, Z1
Fang, J1
Wei, X1
Cheng, P1
Jiao, R1
Liu, X1
Li, Y1
Xing, Y1
Tang, J1
Jin, L1
Li, T1
Alegría-Díaz, A1
Valdez-Ortiz, R1
Murguía-Romero, M1
Jiménez-Flores, R1
Villalobos-Molina, R1
Mummidi, S1
Duggirala, R1
López-Alvarenga, JC1
Pérez-Navarro, M1
Mudassir, HA1
Qureshi, SA1
Azmi, MB1
Ahsan, M1
Gomes, JMG1
de Assis Costa, J1
Ribeiro, PVM1
Alfenas, RCG1
Harisa, GI1
Attia, SM1
Ashour, AE1
Abdallah, GM1
Omran, GA1
Touliabah, HE1
Ran, J1
Ma, J1
Liu, Y1
Tan, R1
Liu, H1
Lao, G1
Gonzales, GF1
Tapia, V1
Škrtić, M1
Yang, GK1
Yip, PM1
Cherney, DZ1
Juárez-Reyes, K1
Brindis, F1
Medina-Campos, ON1
Pedraza-Chaverri, J1
Bye, R1
Linares, E1
Mata, R1
Shacham, Y1
Steinvil, A1
Arbel, Y1
Lu, ZY1
Shao, Z1
Li, YL1
Wulasihan, M1
Chen, XH1
Norvik, JV1
Storhaug, HM1
Ytrehus, K1
Jenssen, TG1
Zykova, SN1
Eriksen, BO1
Solbu, MD1
Li, YY1
Yu, Y1
Wang, F1
Xu, C1
Zhang, HQ1
Zhao, M1
Gao, L1
Zhao, JJ1
Su, BY1
Tian, CF1
Gao, BL1
Tong, YH1
Zhao, XH1
Zheng, Y1
Justicia, C1
Salas-Perdomo, A1
Pérez-de-Puig, I1
Deddens, LH1
van Tilborg, GAF1
Castellví, C1
Dijkhuizen, RM1
Chamorro, Á1
Planas, AM1
Sucher, S1
Markova, M1
Hornemann, S1
Pivovarova, O1
Rudovich, N1
Thomann, R1
Schneeweiss, R1
Rohn, S1
Pfeiffer, AFH1
Portugal-Cohen, M1
Kohen, R1
Iffiú-Soltész, Z1
Wanecq, E1
Lomba, A1
Portillo, MP1
Pellati, F1
Szöko, E1
Bour, S1
Woodley, J1
Milagro, FI1
Alfredo Martinez, J1
Valet, P1
Carpéné, C1
Tominaga, M1
Uno, K1
Yagi, K1
Fukui, M1
Hasegawa, G1
Yoshikawa, T1
Nakamura, N1
Nakumura, N1
Kuo, CF1
Luo, SF1
See, LC2
Ko, YS1
Chen, YM2
Hwang, JS1
Chou, IJ1
Chang, HC1
Chen, HW1
Yu, KH1
Liu, ZM1
Ho, SC1
Ho, YP1
Kawada, T1
Moreno, JA1
Hong, E1
Mah, E1
Noh, SK1
Ballard, KD1
Park, HJ1
Volek, JS1
Bruno, RS1
Moreto, F1
de Oliveira, EP1
Manda, RM1
Torezan, GA1
Teixeira, O1
Michelin, E1
Burini, RC1
Damasceno, DC1
Volpato, GT1
de Mattos Paranhos Calderon, I1
Cunha Rudge, MV1
Wang, G1
Li, Q1
Niu, T1
Chen, C1
Xu, X1
Tomita, M1
Murayama, T1
Mizuno, S1
Kayacan, SM1
Kazancioğlu, R1
Oflaz, H1
Tuna, S1
OKUN, R2
RUSSELL, RP2
WILSON, WR1
GROSSI, F1
ISHMAEL, WK1
OWENS, JN1
PAYNE, RW1
HONICK, MD1
TRAVIA, L1
LYON, AF1
DEGRAFF, AC1
CARLINER, NH1
SCHELLING, JL1
DAVIS, M1
HELLER, H1
CHAZAN, JA1
BOSHELL, BR1
Toprak, O1
Cirit, M1
Yesil, M1
Bayata, S1
Tanrisev, M1
Varol, U1
Ersoy, R1
Esi, E1
Reungjui, S1
Roncal, CA1
Mu, W1
Srinivas, TR1
Sirivongs, D1
Johnson, RJ1
Nakagawa, T1
Wales, JK1
Viktora, JK1
Wolff, FW1
Lebacq, E1
Marcq, M1
Herman, JB1
Goldbourt, U1
Grajek, S1
Jasiński, K1
Paradowski, S1
Jurczykowski, T1
Szmydt, W1
Adamski, M1
Cieślicka, T1
Ziemiański, A1
Ochotny, R1
Droszcz, C1
Pop, E1
Popa, I1
Bolcaş, D1
Micle, T1
Segal, N1
Negrău, T1
Serdült, I1
Sirca, D1
Pop, V1
Curteanu, G1
Büch, U1
Jensen, NB1
Joensen, P1
Jensen, J1
Perry, HM1
Wexler, BC2
Ruilope, L1
Alcazar, JM1
Diaz, VP1
Jarillo, MD1
Millet, VG1
Rodicio, JL1
Shapiro, AP1
Traub, YM1
Ochiai, T1
Ishibashi, M1
Fukao, K1
Takahashi, K1
Endo, T1
Yokoyama, I1
Uchida, K1
Ohshima, S1
Takahara, S1
Morozumi, K1
Coniff, RF1
Shapiro, JA1
Robbins, D1
Kleinfield, R1
Seaton, TB1
Beisswenger, P1
McGill, JB1
Motala, AA1
Omar, MA1
Gouws, E1
Chou, P1
Li, CL1
Wu, GS1
Tsai, ST1
Luyckx, FH1
Scheen, AJ1
Desaive, C1
Dewe, W1
Gielen, JE1
Lefebvre, PJ1
Tomura, S1
Kawada, K1
Saito, K1
Lin, YL1
Endou, K1
Hirano, C1
Yanagi, H1
Tsuchiya, S1
Shiba, K1
Iqbal, M1
Probert, LL1
Alhumadi, NH1
Klandorf, H1
Gerhardt, U1
Grosse Hüttmann, M1
Hohage, H1
Martínez-Abundis, E1
González-Ortiz, M1
Grover-Páez, F1
Vera-Hernández, A1
Sun, JH1
Hsu, WC1
Tsai, JS1
Lin, JD1
Lai, SW1
Li, TC1
Ng, KC1
Finnerty, FA1
Martin, H1
Boulud, B1
Martin, C1
Romanet, P1
Lieber, CS2
Hollnagel, H1
McCartney, P1
Marek, H1
Kuklinski, B1
Kellner, K1
Göbel, S1
Grossmann, KD1
Sumi, T1
Umeda, Y1
Carlier, J1
Rorive, G1
Bovy, P1
Cannon, ML1
Tannenbaum, RP1
La Franco, M1
Hollifield, JW1
Klein, S1
Marré, E1
Koza, KD1
Heidelmann, G1
Koch-Weser, J1
Zdichynec, B1
Greenberg, BP1
Shoshkes, M1
Dolder, MA1
Oliver, MF1
Mach, RS1
Edwardson, JM1
Dean, PM1
Prichard, BN1
Owens, CW1
Woolf, AS1
Di Pietro, S1
Suraci, C1
Laurenzi, M1
Mancini, M1
Menotti, A1
Stamler, J2
Stamler, R1
Trevisan, M1
Zanchetti, A1
Feig, PU1
Hyams, DE1
Leverger, G1
Tourani, JM1
Beuzeboc, P1
Schaison, G1
Pupita, F1
Campolucci, G1
Pulido, M1
Belogi, M1
Rotatori, P1
Ansuini, R1
Frausini, G1
Barone, A1
Gaggi, S1
Friedrich, G1
Puschett, JB1
Chwistecki, K1
Mrukowicz, M1
Bochenek, W1
Rotter, A1
Pikiewicz, K1
Słowińska, R1
Swiderska-Błońska, T1
de Gennes, JL1
Thomopoulos, P1
Truffert, J1
Labrousse de Tregomain, B1
Emmrich, R1
Bailey, RR1
Dann, E1
Greenslade, NF1
Little, PJ1
McRae, CU1
Utley, WL1
Kirkendall, WM1
Azer, M1
Curtis, J1
Horrigan, F1
Ahearn, D1
Varney, R1
Sandler, SG1
Kurtzman, NA1
Pillay, VK1
Paasikivi, J1
Raja, RM1
Kramer, MS1
Manchanda, R1
Lazaro, N1
Rosenbaum, JL1
Perlman, LV1
Kennedy, BW1
Hayner, NS2
Freis, ED1
Leiter, L1
Johnson, BF1
Kapur, M1
Epstein, FH1
Aur, RJ1
Simone, JV1
Pratt, CB1
Jouve, A1
Avril, P1
Mary, Y1
Pierron, J1
Pons, JC1
Wise, PH1
Edwards, FM1
Thomas, DW1
Elliot, RB1
Hatcher, L1
Craig, R1
Heyden, S2
Hood, B1
Olander, R1
Orndahl, G1
Leon, A1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Deep Phenotyping Approach to Assess the Effect of Uric Acid Lowering in Patients With Uncomplicated Type 1 Diabetes Mellitus[NCT02344602]Phase 473 participants (Actual)Interventional2012-12-18Completed
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial[NCT02502071]Phase 445 participants (Actual)Interventional2017-01-31Completed
Uric Acid and Hypertension in African Americans[NCT00241839]Phase 3150 participants (Actual)Interventional2005-08-31Completed
[NCT00005232]0 participants Observational1988-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Number of Participants With Urine Uric Acid Precipitation by Polarized Microscopy

Urine uric acid crystals were identified by polarized microscopy (Polarized light imaging Zeiss Axiovert 135; 0.3NA objective), and pictures were captured from each urine sample. UA crystals were defined dichotomously as being present or absent. (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)

Interventionparticipants (Number)
Day 1 (pre-therapy)Day 2 (post-therapy)
Sodium Bicarbonate143

Change in Urine Uric Acid Concentration (Increased Solubility) by Assay

Urine uric acid were evaluated using a QuantiChrom UA kit assay (DIUA-250) with quantitative colorimetric UA determination at 590 nm (BioAssay System, California, USA). (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)

Interventionmg/dl (Geometric Mean)
Day 1 (pre-therapy)Day 2 (post-therapy)
Sodium Bicarbonate23.8122.30

Change in Diastolic Blood Pressure by Cuff 8-10 Weeks Minus Baseline

"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo

Interventionmm Hg (Mean)
A (Allopurinol)3.44
B (Placebo)-0.83

Change in Overall Mean BP From Those Obtained by 24 Hour Ambulatory Blood Pressure Measurements (ABPM) 8-10 Weeks Minus Baseline.

Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)

Interventionmm Hg (Mean)
A (Allopurinol)-5.9
B (Placebo)0.90

Change in Systolic Blood Pressure by Cuff After 8-10 Weeks Minus Baseline

"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo

Interventionmm Hg (Mean)
A (Allopurinol)0.21
B (Placebo)-0.95

Change in Uric Acid (UA) Levels: Baseline Less End of Treatment

Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)

Interventionmg/dl (Mean)
A (Allopurinol)2.29
B (Placebo)0.14

Reviews

15 reviews available for uric acid and Hyperglycemia

ArticleYear
Effects of Sodium Glucose Cotransporter-2 Inhibitors on Serum Uric Acid in Type 2 Diabetes Mellitus.
    Diabetes technology & therapeutics, 2017, Volume: 19, Issue:9

    Topics: Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hyperglycemia; Hyperuricemia; Hypoglyc

2017
Effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:2

    Topics: Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Type 2; Glucosides; Humans; Hyperglycemia; H

2018
Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: a multifactorial entity.
    Journal of nephrology, 2016, Volume: 29, Issue:2

    Topics: Acute Kidney Injury; Anemia; Biomarkers; Blood Glucose; Contrast Media; Hemodynamics; Hemoglobins; H

2016
[Effect of hyperglycemia and insulin resistance on serum uric acid].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Adult; Blood Glucose; Glycosuria; Humans; Hyperglycemia; Hyperuricemia; Insulin; Insulin Resistance;

2003
[2 IMPORTANT SIDE-EFFECTS OF SALURETIC DRUGS: HYPERURICEMIC AND HYPERGLYCEMIC SYNDROMES].
    La Clinica terapeutica, 1963, Sep-15, Volume: 26

    Topics: Acetazolamide; Blood Chemical Analysis; Chlorothiazide; Chlorthalidone; Diuretics; Humans; Hydrochlo

1963
[Carbohydrates in infusion therapy].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1981, Volume: 16, Issue:2

    Topics: Antibody Formation; Basal Metabolism; Bilirubin; Carbohydrate Metabolism; Fructose; Gluconeogenesis;

1981
Interference of ethanol in hepatic cellular metabolism.
    Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252

    Topics: Acetaldehyde; Acetates; Acidosis; Alcohol Oxidoreductases; Cholesterol; Drug Synergism; Drug Toleran

1975
Diazoxide.
    The New England journal of medicine, 1976, Jun-03, Volume: 294, Issue:23

    Topics: Blood Pressure; Cardiac Output; Diazoxide; Diuretics; Drug Synergism; Emergencies; Female; Half-Life

1976
Adverse reactions to diuretics.
    European heart journal, 1992, Volume: 13 Suppl G

    Topics: Blood Volume; Diuretics; Drug Interactions; Humans; Hyperglycemia; Hyperlipidemias; Uric Acid; Water

1992
Cellular mechanism of action of loop diuretics: implications for drug effectiveness and adverse effects.
    The American journal of cardiology, 1986, Jan-24, Volume: 57, Issue:2

    Topics: Animals; Chlorides; Diuretics; Dose-Response Relationship, Drug; Drug Resistance; Erythrocyte Membra

1986
The elderly patient. A special case for diuretic therapy.
    Drugs, 1986, Volume: 31 Suppl 4

    Topics: Aged; Aging; Cerebrovascular Disorders; Diuretics; Heart Failure; Humans; Hyperglycemia; Hyperlipide

1986
Liver adaptation and injury in alcoholism.
    The New England journal of medicine, 1973, Feb-15, Volume: 288, Issue:7

    Topics: Acidosis; Adaptation, Physiological; Alcoholism; Animals; Collagen; Cytosol; Drug Interactions; Etha

1973
Diuretics and hypertension.
    Journal of the Iowa Medical Society, 1972, Volume: 62, Issue:1

    Topics: Azides; Benzothiadiazines; Blood Vessels; Diuretics; Extracellular Space; Humans; Hyperglycemia; Hyp

1972
Antihypertensive action of benzothiadiazines.
    New York state journal of medicine, 1968, Jan-15, Volume: 68, Issue:2

    Topics: Benzothiadiazines; Chlorothiazide; Guanethidine; Humans; Hyperglycemia; Hypertension; Hypokalemia; M

1968
Combinations of diuretics in the treatment of edema.
    American heart journal, 1970, Volume: 80, Issue:3

    Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu

1970

Trials

7 trials available for uric acid and Hyperglycemia

ArticleYear
High calcium intake from fat-free milk, body composition and glycaemic control in adults with type 2 diabetes: a randomised crossover clinical trial.
    The British journal of nutrition, 2019, 08-14, Volume: 122, Issue:3

    Topics: Adult; Animals; Body Composition; Body Mass Index; Body Weight; Calcium, Dietary; Cross-Over Studies

2019
Comparison of the effects of diets high in animal or plant protein on metabolic and cardiovascular markers in type 2 diabetes: A randomized clinical trial.
    Diabetes, obesity & metabolism, 2017, Volume: 19, Issue:7

    Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Dairy Products; Diabe

2017
The effects of isoflavones combined with soy protein on lipid profiles, C-reactive protein and cardiovascular risk among postmenopausal Chinese women.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2012, Volume: 22, Issue:9

    Topics: Aged; Asian People; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2012
Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Antioxidants; Arginine; Ascorbic Acid; Blood Glucose; Brachial Artery; Dietary Su

2013
The effect of hydrochlorothiazide in normal subjects receiving high fat or high carbohydrate diets.
    The American journal of the medical sciences, 1967, Volume: 254, Issue:4

    Topics: Blood Glucose; Dietary Carbohydrates; Dietary Fats; Diuretics; Fatty Acids, Nonesterified; Female; G

1967
Japanese multicenter studies of FK 506 in renal transplantation. Japanese FK 506 Study Group.
    Transplantation proceedings, 1995, Volume: 27, Issue:1

    Topics: Amylases; Cholesterol; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Graft Rejection;

1995
Reduction of glycosylated hemoglobin and postprandial hyperglycemia by acarbose in patients with NIDDM. A placebo-controlled dose-comparison study.
    Diabetes care, 1995, Volume: 18, Issue:6

    Topics: Acarbose; Adult; Analysis of Variance; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Diet,

1995

Other Studies

100 other studies available for uric acid and Hyperglycemia

ArticleYear
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin.
    Cellular and molecular life sciences : CMLS, 2022, May-03, Volume: 79, Issue:5

    Topics: Anti-Inflammatory Agents; Diabetes Mellitus, Type 2; Endothelial Cells; Glucose; Humans; Hyperglycem

2022
The effects of cardiometabolic factors on the association between serum uric acid and risk of all-cause mortality in adults with congestive heart failure.
    Postgraduate medicine, 2023, Volume: 135, Issue:5

    Topics: Adult; Cardiovascular Diseases; Heart Failure; Humans; Hyperglycemia; Hypertension; Nutrition Survey

2023
Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps.
    PloS one, 2023, Volume: 18, Issue:6

    Topics: Adenomatous Polyps; Adult; Colonic Polyps; Cross-Sectional Studies; Female; Humans; Hyperglycemia; M

2023
Associations of serum uric acid with cardiovascular disease risk factors: a retrospective cohort study in southeastern China.
    BMJ open, 2023, 09-27, Volume: 13, Issue:9

    Topics: Cardiovascular Diseases; China; Female; Humans; Hyperglycemia; Hypertension; Hyperuricemia; Male; Re

2023
Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
    International journal of molecular sciences, 2019, Sep-21, Volume: 20, Issue:19

    Topics: Animals; Anti-Inflammatory Agents; Body Weight; Chemokine CCL2; Collagen; Diabetic Nephropathies; Fe

2019
Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke.
    Translational stroke research, 2021, Volume: 12, Issue:2

    Topics: Brain Ischemia; Gluconates; Humans; Hyperglycemia; Laboratories, Clinical; Stroke; Uric Acid

2021
The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Biomarkers; Blood Glucose; Body Mass Index; Dyslipidemias; Female; Follow-Up Studies; Glomerular Fil

2021
Renal and Vascular Effects of Uric Acid Lowering in Normouricemic Patients With Uncomplicated Type 1 Diabetes.
    Diabetes, 2017, Volume: 66, Issue:7

    Topics: Adult; Angiotensin II; Blood Pressure; Case-Control Studies; Diabetes Mellitus, Type 1; Febuxostat;

2017
Interactive association of serum uric acid and total bilirubin with renal dysfunction among community-dwelling subjects.
    International urology and nephrology, 2017, Volume: 49, Issue:8

    Topics: Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Antihypertensive Agents; Bilirubin; Body Mas

2017
A Novel Multi-Epitope Vaccine Based on Urate Transporter 1 Alleviates Streptozotocin-Induced Diabetes by Producing Anti-URAT1 Antibody and an Immunomodulatory Effect in C57BL/6J Mice.
    International journal of molecular sciences, 2017, Oct-16, Volume: 18, Issue:10

    Topics: Animals; Antioxidants; Autoantibodies; Autoantigens; Cytokines; Diabetes Mellitus, Experimental; Dia

2017
Clinical Significance of Serum Uric Acid Levels in Mexican Young Adults.
    Contributions to nephrology, 2018, Volume: 192

    Topics: Adolescent; Adult; Cholesterol, LDL; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Hu

2018
Ethanolic seeds extract of Centratherum anthelminticum reduces oxidative stress in type 2 diabetes.
    Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:3(Suppleme

    Topics: Alanine Transaminase; Animals; Antioxidants; Asteraceae; Bilirubin; Creatine Kinase; Diabetes Mellit

2018
Cigarette smoking and hyperglycemia increase renal response to low levels of cadmium in welders: cystatin C as a sensitive marker.
    Biological trace element research, 2014, Volume: 158, Issue:3

    Topics: Air Pollutants, Occupational; Analysis of Variance; Biomarkers; Cadmium; Creatinine; Cystatin C; Dia

2014
Low protein diet inhibits uric acid synthesis and attenuates renal damage in streptozotocin-induced diabetic rats.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Albuminuria; Animals; Cell Proliferation; Cell Size; Diabetes Mellitus, Experimental; Diabetic Nephr

2014
Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes.
    Journal of basic and clinical physiology and pharmacology, 2015, Volume: 26, Issue:1

    Topics: Adult; Aged; Altitude; Biomarkers; Dyslipidemias; Female; gamma-Glutamyltransferase; Hemoglobins; Hu

2015
Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus.
    American journal of physiology. Renal physiology, 2015, Jan-15, Volume: 308, Issue:2

    Topics: Adult; Benzhydryl Compounds; Case-Control Studies; Diabetes Mellitus, Type 1; Female; Glucosides; Gl

2015
Hypoglycemic, antihyperglycemic, and antioxidant effects of the edible plant Anoda cristata.
    Journal of ethnopharmacology, 2015, Feb-23, Volume: 161

    Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Flavones; Flavonoids; Free Ra

2015
Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study.
    World journal of gastroenterology, 2016, Apr-07, Volume: 22, Issue:13

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Body Mass Index; China; Cholesterol, HDL; Cholesterol, LDL;

2016
Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study.
    BMC cardiovascular disorders, 2016, May-10, Volume: 16

    Topics: Aged; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; Chi-Square Distribution; Female; H

2016
[Investigation of metabolic disorders in patients with familial fatty liver disease and their first-degree relatives].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2016, Volume: 24, Issue:6

    Topics: Blood Glucose; Body Mass Index; China; Family; Fatty Liver; Humans; Hyperglycemia; Metabolic Syndrom

2016
Correlation of the leucocyte count with traditional and non-traditional components of metabolic syndrome.
    Postgraduate medicine, 2016, Volume: 128, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; China; Female; Fibrinogen; Humans; Hy

2016
Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice.
    Translational stroke research, 2017, Volume: 8, Issue:3

    Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Hyperglycemia; Intercellular Adhesion Molecule-

2017
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase.
    Journal of dermatological science, 2009, Volume: 55, Issue:2

    Topics: Biomarkers; Cell Hypoxia; Cell Line; Cell Survival; Glucose; Glutathione; Glutathione Disulfide; Hum

2009
Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice.
    Pharmacological research, 2010, Volume: 61, Issue:4

    Topics: Adipocytes; Administration, Oral; Animals; Aorta; Benzylamines; Blood Glucose; Cholesterol; Hydrogen

2010
Association between capacity of interferon-alpha production and metabolic parameters.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2010, Volume: 30, Issue:6

    Topics: Adult; Aged; Blood Glucose; Body Mass Index; Disease Susceptibility; Female; Humans; Hyperglycemia;

2010
Hyperuricaemia and accelerated reduction in renal function.
    Scandinavian journal of rheumatology, 2011, Volume: 40, Issue:2

    Topics: Adult; Aged; Chronic Disease; Cohort Studies; Creatinine; Disease Progression; Female; Follow-Up Stu

2011
Predictors of the development of metabolic syndrome in male workers: a 3-year follow-up study.
    Journal of occupational and environmental medicine, 2012, Volume: 54, Issue:3

    Topics: Adult; Age Factors; Alcohol Drinking; Cholesterol, HDL; Confidence Intervals; Exercise; Follow-Up St

2012
A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2013, Volume: 23, Issue:6

    Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Fruc

2013
Pathological and behavioral risk factors for higher serum C-reactive protein concentrations in free-living adults--a Brazilian community-based study.
    Inflammation, 2013, Volume: 36, Issue:1

    Topics: Abdominal Fat; Adult; Aged; Aged, 80 and over; Anthropometry; Blood Glucose; Body Mass Index; Brazil

2013
Oxidative stress and diabetes in pregnant rats.
    Animal reproduction science, 2002, Aug-15, Volume: 72, Issue:3-4

    Topics: Animals; Antioxidants; Congenital Abnormalities; Diabetes Mellitus, Experimental; Female; Gestationa

2002
Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus.
    Chinese medical journal, 2002, Volume: 115, Issue:9

    Topics: Adult; Aged; Alleles; Body Mass Index; Diabetes Mellitus, Type 2; Glycogen Synthase; Humans; Hypergl

2002
Comparison of different risk factors that result in endothelial damage leading to diabetic microangiopathy.
    Southern medical journal, 2003, Volume: 96, Issue:4

    Topics: Adult; Antigens; Diabetes Complications; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyper

2003
USE OF DIAZOXIDE WITH TRICHLORMETHIAZIDE FOR HYPERTENSION.
    Archives of internal medicine, 1963, Volume: 112

    Topics: Acidosis; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Body Weight; Diazoxide; Hyperg

1963
DIABETES MELLITUS IN PATIENTS WITH GOUTY ARTHRITIS.
    JAMA, 1964, Oct-26, Volume: 190

    Topics: Arthritis; Arthritis, Gouty; Blood; Diabetes Mellitus; Drug Therapy; Gout; Humans; Hyperglycemia; Ur

1964
CORRELATED VARIATIONS OF THE TOTAL LIPEMIA, CHOLESTEROLEMIA, BETA/ALPHA LIPOPROTEIN RATIO AND ORAL GLUCOSE TOLERANCE TEST.
    Nutritio et dieta; European review of nutrition and dietetics, 1964, Volume: 6

    Topics: Biomedical Research; Blood; Blood Glucose; Carbohydrate Metabolism; Cholesterol; Glucose Tolerance T

1964
DIURETIC THERAPY. VI. METABOLIC COMPLICATIONS OF THIAZIDE THERAPY AND THEIR CORRECTION.
    American heart journal, 1964, Volume: 68

    Topics: Bendroflumethiazide; Blood; Blood Urea Nitrogen; Diuretics; Humans; Hydrochlorothiazide; Hyperglycem

1964
THIAZIDE- AND PHTHALIMIDINE-INDUCED HYPERGLYCEMIA IN HYPERTENSIVE PATIENTS.
    JAMA, 1965, Feb-15, Volume: 191

    Topics: Amylases; Blood Chemical Analysis; Chlorthalidone; Creatine; Creatinine; Diabetes Mellitus; Drug The

1965
TOXICITY OF DIURETICS.
    The Practitioner, 1965, Volume: 194

    Topics: Blood; Diuretics; Gastrointestinal Diseases; Gout; Hematologic Diseases; Humans; Hyperglycemia; Hype

1965
ETIOLOGICAL FACTORS IN THIAZIDE-INDUCED OR AGGRAVATED DIABETES MELLITUS.
    Diabetes, 1965, Volume: 14

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Amylases; Blood Chemical Analysis; Blood Urea Nitrogen;

1965
Impact of diabetic and pre-diabetic state on development of contrast-induced nephropathy in patients with chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:3

    Topics: Blood Glucose; Contrast Media; Coronary Angiography; Coronary Disease; Creatinine; Diabetes Mellitus

2007
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:10

    Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Diuretics; Fructose; Gout Suppressants; Hydrochlo

2007
A study of the mechanism of ethacrynic acid induced hyperglycemia.
    Revue francaise d'etudes cliniques et biologiques, 1967, Volume: 12, Issue:2

    Topics: Carbohydrate Metabolism; Diabetes Mellitus; Ethacrynic Acid; Humans; Hydrocortisone; Hyperglycemia;

1967
Uric acid and diabetes: observations in a population study.
    Lancet (London, England), 1982, Jul-31, Volume: 2, Issue:8292

    Topics: Adult; Blood Glucose; Diabetes Mellitus; Humans; Hypercholesterolemia; Hyperglycemia; Male; Middle A

1982
[Angina pectoris in patients with arterial hypertension aged 40-59 years. I. Incidence and risk factors].
    Kardiologia polska, 1984, Volume: 27, Issue:7

    Topics: Adult; Angina Pectoris; Humans; Hypercholesterolemia; Hyperglycemia; Hypertension; Male; Middle Aged

1984
Study on the detection and epidemiology of risk factors in ischemic cardiopathy in some localities of Bihor county.
    La Sante publique, 1983, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Coronary Disease; Diabetes Complications; Female;

1983
[Status epilepticus complicated by disseminated intravascular coagulation].
    Ugeskrift for laeger, 1982, Jul-12, Volume: 144, Issue:28

    Topics: Aged; Disseminated Intravascular Coagulation; Epilepsy, Tonic-Clonic; Female; Humans; Hyperglycemia;

1982
Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents.
    American heart journal, 1983, Volume: 106, Issue:1 Pt 2

    Topics: Adult; Antihypertensive Agents; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Humans; Hy

1983
[Management of multiple metabolic overcharge].
    L'Infirmiere francaise, 1980, Issue:220

    Topics: Diet; Humans; Hyperglycemia; Hyperlipidemias; Metabolic Diseases; Uric Acid

1980
Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats.
    Atherosclerosis, 1981, Volume: 39, Issue:2

    Topics: Animals; Arteries; Arteriosclerosis; Blood Glucose; Blood Pressure; Body Weight; Corticosterone; Cre

1981
A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension.
    Clinical therapeutics, 1980, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Aged; Amiloride; Blood Chemical Analysis; Blood Pressure; Body Weight; Drug Thera

1980
Complications of antihypertensive therapy.
    American family physician, 1981, Volume: 23, Issue:3

    Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydr

1981
High risk of progression to NIDDM in South-African Indians with impaired glucose tolerance.
    Diabetes, 1993, Volume: 42, Issue:4

    Topics: Analysis of Variance; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Ethnicity; Fasting; Fem

1993
Progression to type 2 diabetes among high-risk groups in Kin-Chen, Kinmen. Exploring the natural history of type 2 diabetes.
    Diabetes care, 1998, Volume: 21, Issue:7

    Topics: Adult; Age Factors; Blood Glucose; Body Constitution; Body Mass Index; Cholesterol, HDL; Diabetes Me

1998
Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity.
    Diabetes & metabolism, 1998, Volume: 24, Issue:4

    Topics: Adult; Belgium; Body Mass Index; Body Weight; Cholesterol; Cholesterol, HDL; Cohort Studies; Comorbi

1998
Prevalence of microalbuminuria and relationship to the risk of cardiovascular disease in the Japanese population.
    American journal of nephrology, 1999, Volume: 19, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Albuminuria; Blood Glucose; Blood Proteins; Chi-Square

1999
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1999, Volume: 54, Issue:4

    Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Enzyme

1999
Influence of hyperglycemia and hyperuricemia on long-term transplant survival in kidney transplant recipients.
    Clinical transplantation, 1999, Volume: 13, Issue:5

    Topics: Adult; Creatinine; Female; Follow-Up Studies; Graft Survival; Humans; Hyperglycemia; Kidney Transpla

1999
[Excretion of uric aid, sodium, and potassium in preeclampsia patients and its behavior in acute hyperglycemia-hyperinsulinemia].
    Ginecologia y obstetricia de Mexico, 1999, Volume: 67

    Topics: Acute Disease; Adult; Female; Humans; Hyperglycemia; Hyperinsulinism; Potassium; Pre-Eclampsia; Preg

1999
Hyperinsulinemia and insulin resistance related metabolic syndrome.
    Chang Gung medical journal, 2001, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Humans; Hyperglycemia;

2001
Body mass index and its related factors in the elderly.
    Annals of the Academy of Medicine, Singapore, 2001, Volume: 30, Issue:4

    Topics: Aged; Aged, 80 and over; Body Mass Index; Comorbidity; Cross-Sectional Studies; Female; Humans; Hype

2001
Diuretics as initial treatment for essential hypertension.
    British journal of clinical pharmacology, 1979, Volume: 7 Suppl 2

    Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Humans; Hyperg

1979
[Internal ear deafness and metabolic disorders].
    JFORL. Journal francais d'oto-rhino-laryngologie; audiophonologie et chirurgie maxillo-faciale, 1976, Volume: 25, Issue:7

    Topics: Adult; Aged; Deafness; Diabetes Complications; Female; Humans; Hyperglycemia; Labyrinth Diseases; Ma

1976
Relationship of fasting and post-load serum glucose to prevalence of ECG abnormalities in forty-year-old men: from the Glostrup population studies.
    Journal of chronic diseases, 1979, Volume: 32, Issue:11-12

    Topics: Adult; Blood Glucose; Blood Pressure; Body Weight; Coronary Disease; Cross-Sectional Studies; Denmar

1979
[Various mechanisms of disorders of carbohydrate metabolism in myocardial infarct].
    Kardiologiia, 1979, Volume: 19, Issue:5

    Topics: Acute Disease; Adult; Aged; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin

1979
Hyperuricemia in the rat following hypothalamic stimulation.
    Life sciences, 1977, Dec-01, Volume: 21, Issue:11

    Topics: Allantoin; Animals; Electric Stimulation; Hyperglycemia; Hypothalamus; Hypothalamus, Middle; Male; R

1977
[Diuretics in cardiac insufficiency].
    Acta clinica Belgica, 1977, Volume: 32, Issue:3

    Topics: Alkalosis; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Diuretics; Diuretics, Osmotic; Heart Fa

1977
Diuretics in the treatment of hypertension.
    American pharmacy, 1978, Volume: 18, Issue:5

    Topics: Benzothiadiazines; Diuretics; Humans; Hyperglycemia; Hypertension; Hypokalemia; Sodium Chloride Symp

1978
Biochemical consequences of diuretic therapy in hypertension.
    Journal of the Tennessee Medical Association, 1978, Volume: 71, Issue:10

    Topics: Benzothiadiazines; Diuretics; Humans; Hypercalcemia; Hyperglycemia; Hypertension; Hypokalemia; Sodiu

1978
[Retinal thromboses with metabolic disturbances (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1978, Volume: 173, Issue:4

    Topics: Adult; Age Factors; Aged; Female; Glucose; Humans; Hyperglycemia; Hyperlipidemias; Hypertension; Lip

1978
[Conclusions from a clinical study of myocardial infarction in young men under 40 years of age].
    Vnitrni lekarstvi, 1977, Volume: 23, Issue:2

    Topics: Adult; Age Factors; Death, Sudden; Humans; Hypercholesterolemia; Hyperglycemia; Male; Middle Aged; M

1977
Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis.
    Metabolism: clinical and experimental, 1977, Volume: 26, Issue:12

    Topics: Animals; Arteriosclerosis; Female; Hyperglycemia; Hyperlipidemias; Hypertension; Male; Oxonic Acid;

1977
Systolic hypertension, hyperuricemia, and hyperglycemia as risk factors in cardiovascular disease.
    The Journal of the Medical Society of New Jersey, 1976, Volume: 73, Issue:3

    Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Humans; Hyperglycemia;

1976
Myocardial infarction in young men. Study of risk factors in nine countries.
    British heart journal, 1975, Volume: 37, Issue:5

    Topics: Adult; Australia; Body Weight; Cholesterol; Coronary Disease; Diabetes Complications; Germany, West;

1975
[Editorial: Edema from diuretics abuse].
    Schweizerische medizinische Wochenschrift, 1976, Feb-07, Volume: 106, Issue:6

    Topics: Adult; Diuretics; Edema; Female; Humans; Hyperaldosteronism; Hyperglycemia; Hypokalemia; Hyponatremi

1976
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure.
    Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11

    Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Ino

1992
Metabolic abnormalities in first-degree relatives of type 2 diabetics.
    Bollettino della Societa italiana di biologia sperimentale, 1990, Volume: 66, Issue:7

    Topics: Adult; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance

1990
Multiple risk factors in hypertension: results from the Gubbio study.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1990, Volume: 8, Issue:1

    Topics: Adult; Age Factors; Aged; Antiporters; Carrier Proteins; Erythrocytes; Female; Humans; Hypercholeste

1990
[Acute hyperleukocytic lymphoblastic leukemia (greater than or equal to 100,000 leukocytes/mm3). Metabolic changes during induction treatment. Study, prevention and treatment].
    Archives francaises de pediatrie, 1985, Volume: 42, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Emergencies; Hemostasis; Humans; Hyperglycemia; Hyperkalemia; I

1985
[Negative effects of diuretics].
    La Clinica terapeutica, 1985, Oct-15, Volume: 115, Issue:1

    Topics: Alkalosis; Diuretics; Heart Diseases; Humans; Hyperglycemia; Hypokalemia; Hyponatremia; Insulin; Liv

1985
[Etiology and pathogenesis of sudden deafness].
    Laryngologie, Rhinologie, Otologie, 1985, Volume: 64, Issue:2

    Topics: Adult; Cardiovascular Diseases; Female; Hearing Loss, Sudden; Humans; Hyperglycemia; Hyperlipidemias

1985
Diuretic therapy update.
    Comprehensive therapy, 1985, Volume: 11, Issue:10

    Topics: Acid-Base Imbalance; Acute Kidney Injury; Diet, Sodium-Restricted; Diuretics; Ear Diseases; Heart Fa

1985
[Serum glucose and uric acid levels in men aged 35-54 years employed by industrial plants in Wrocław].
    Przeglad lekarski, 1985, Volume: 42, Issue:6

    Topics: Adult; Blood Glucose; Humans; Hyperglycemia; Male; Middle Aged; Occupational Medicine; Poland; Uric

1985
[Hyperlipemias due to alcohol].
    Nutrition and metabolism, 1972, Volume: 14, Issue:3

    Topics: Adult; Alcoholism; Body Weight; Cardiovascular Diseases; Cholesterol; Dietary Carbohydrates; Ethanol

1972
[Prevention of arteriosclerosis].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1974, Aug-15, Volume: 29, Issue:16

    Topics: Arteriosclerosis; Cholesterol; Diabetic Angiopathies; Diet Therapy; Female; Gout; Humans; Hyperglyce

1974
Urinary stones: a prospective study of 350 patients.
    The New Zealand medical journal, 1974, May-22, Volume: 79, Issue:516

    Topics: Adult; Aged; Calcium; Cystinuria; Female; Humans; Hypercalcemia; Hyperglycemia; Male; Metabolic Dise

1974
Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma.
    JAMA, 1972, Jun-19, Volume: 220, Issue:12

    Topics: Adult; Chlorthalidone; Dehydration; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans;

1972
Renal reabsorption of glucose in health and disease.
    Archives of internal medicine, 1973, Volume: 131, Issue:6

    Topics: Biological Transport; Fanconi Syndrome; Female; Glomerular Filtration Rate; Glucose; Glycosuria, Ren

1973
Long-term treatment of patients with abnormal intravenous glucose tolerance after myocardial infarction.
    Advances in metabolic disorders, 1973, Volume: 2

    Topics: Cholesterol; Evaluation Studies as Topic; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test

1973
Peritoneal dialysis with fructose dialysate. Prevention of hyperglycemia and hyperosmolality.
    Annals of internal medicine, 1973, Volume: 79, Issue:4

    Topics: Blood; Diabetic Nephropathies; Fructose; Glucose; Humans; Hydrogen-Ion Concentration; Hyperglycemia;

1973
Primary and secondary renal failure in a total community (Tecumseh, Michigan): preponderance in the elderly and possible antecedent factors.
    Journal of the American Geriatrics Society, 1974, Volume: 22, Issue:1

    Topics: Age Factors; Aged; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Cholesterol; Coronary Disease

1974
The influences of rate of injection upon the effects of diazoxide.
    The American journal of the medical sciences, 1972, Volume: 263, Issue:6

    Topics: Adult; Aged; Aminohippuric Acids; Blood Pressure; Chlorides; Creatinine; Diazoxide; Female; Humans;

1972
Coronary heart disease: risk factors as guides to preventive action.
    Preventive medicine, 1972, Volume: 1, Issue:1

    Topics: Adult; Coronary Disease; Dietary Fats; Female; Humans; Hypercholesterolemia; Hyperglycemia; Hyperten

1972
Metabolic factors in the epidemiology of arterial disease.
    Acta diabetologica latina, 1971, Volume: 8 Suppl 1

    Topics: Adult; Age Factors; Arteriosclerosis; Blood Glucose; Blood Pressure; Body Weight; Cerebrovascular Di

1971
Successful remission induction in children with acute lymphocytic leukemia at high risk for treatment failure.
    Cancer, 1971, Volume: 27, Issue:6

    Topics: Amylases; Asparaginase; Blood Coagulation Disorders; Child; Child, Preschool; Daunorubicin; Female;

1971
[Clinical and biological trials of C.P.I.B.-aluminium].
    Marseille medical, 1970, Volume: 107, Issue:8

    Topics: Adult; Aged; Aluminum; Arteriosclerosis; Butyrates; Cholesterol; Female; Humans; Hydroxides; Hypergl

1970
Hyperglycaemia in the urbanized Aboriginal. The Davenport survey.
    The Medical journal of Australia, 1970, Nov-28, Volume: 2, Issue:22

    Topics: Activities of Daily Living; Adolescent; Adult; Australia; Blood Glucose; Child; Cholesterol; Civiliz

1970
[Dietary management of hazard factors in cardiovascular diseases].
    Deutsches medizinisches Journal, 1970, Volume: 21, Issue:16

    Topics: Aged; Cardiovascular Diseases; Diabetes Complications; Diet Therapy; Humans; Hypercholesterolemia; H

1970
[The BBC study. Applied epidemiology of ischemic heart diseases].
    Archiv fur Kreislaufforschung, 1967, Volume: 53, Issue:1

    Topics: Adult; Body Weight; Caffeine; Cholesterol; Coronary Disease; Epidemiologic Methods; Hematocrit; Huma

1967
[Uric acid, hypertension, blood vessels and serum lipids].
    Lakartidningen, 1968, Feb-07, Volume: 65, Issue:6

    Topics: Cardiovascular Diseases; Cholesterol; Diuretics; Humans; Hyperglycemia; Hypertension; Kidney Disease

1968
[Factors of coronary risk].
    Medicina interna, 1969, Feb-02, Volume: 21, Issue:2

    Topics: Castration; Coronary Disease; Dietary Fats; Heart Diseases; Humans; Hyperglycemia; Hypertension; Neu

1969