uric acid and HbS Disease studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

Excerpt	Relevance	Reference
" The mechanism of development of hyperuricemia (defined, serum uric acid (UA) ≥ 5."	3.96	Hyperuricemia is associated with a lower glomerular filtration rate in pediatric sickle cell disease patients. ( Beach, I; Feig, D; Kaspar, CDW; Newlin, J; Sisler, I; Smith, W, 2020)
"The mean eGFR was statistically significantly lower in patients with hyperuricemia than in those with normal uric acid levels (143 vs."	3.85	Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemia. ( Cutter, GR; Feig, DI; Howard, TH; Lebensburger, JD; Muntner, P, 2017)
"Uric acid level was significantly increased in children with Hb-SS compared to corresponding values in control group (4."	1.40	Renal function in children suffering from sickle cell disease: challenge of early detection in highly resource-scarce settings. ( Aloni, MN; Ekila, MB; Gini-Ehungu, JL; Lepira, FB; Ngiyulu, RM; Nseka, NM; Nsibu, CN, 2014)
"Mean uric acid serum level was 281."	1.38	[Hyperuricemia in sickle cell disease in France]. ( Arlet, JB; Chatellier, G; Courbebaisse, M; de Montalembert, M; Pouchot, J; Prié, D; Ribeil, JA, 2012)
"Patients with sickle cell anemia have various forms of renal dysfunction."	1.31	Renal function in children with sickle cell anemia. ( Aldudak, B; Anarat, A; Anarat, R; Bayazit, AK; Dikmen, N; Gali, E; Kilinç, Y; Noyan, A; Ozel, A, 2002)
"Uric acid excretion was higher in the sicklers, and so was the mean urine acid to creatinine ratio (0."	1.27	Effect of dietary nitrogen on urinary excretion of non-protein nitrogen in adolescent sickle cell patients. ( Addae, SK; Apatu, RS; Odonkor, PO; Yamamoto, S, 1984)
"Patients with sickle cell anemia were often normouricemic despite urate overproduction."	1.26	The natural history of urate overproduction in sickle cell anemia. ( Diamond, HS; Holden, D; Meisel, AD, 1979)
"A nearly 72-old black male with sickle cell anemia suffered from heart failure, hypertension, chronic impaired kidney function with hyperuricemia and gout."	1.25	Long survival in sickle cell anemia. ( Huisman, TH; Sar, AV, 1975)

Research

Studies (38)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Feasibility as Measured by the Number of Patients That Accept Enrollment, Remain Adherent to Losartan, and Remain Adherent to Study Procedures.

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (60.53)	18.7374
1990's	4 (10.53)	18.2507
2000's	2 (5.26)	29.6817
2010's	8 (21.05)	24.3611
2020's	1 (2.63)	2.80

Authors	Studies
Kaspar, CDW	1
Beach, I	1
Newlin, J	1
Sisler, I	1
Feig, D	1
Smith, W	1
Lebensburger, JD	1
Cutter, GR	1
Howard, TH	1
Muntner, P	1
Feig, DI	1
Aloni, MN	1
Ngiyulu, RM	1
Gini-Ehungu, JL	1
Nsibu, CN	1
Ekila, MB	1
Lepira, FB	1
Nseka, NM	1
Gupta, S	1
Yui, JC	1
Xu, D	1
Fitzhugh, CD	1
Clark, C	1
Siddiqui, S	1
Conrey, AK	1
Kato, GJ	2
Minniti, CP	2
Castilhos, LG	1
de Oliveira, JS	1
Adefegha, SA	1
Magni, LP	1
Doleski, PH	1
Abdalla, FH	1
de Andrade, CM	1
Leal, DBR	1
Abhishek, K	1
Sohail, M	1
Kumar, R	1
Patra, PK	1
Choudhary, SB	1
Taylor, JG	1
Hildesheim, M	1
O'Neal, P	1
Wilson, J	1
Castro, O	1
Gordeuk, VR	1
Cerqueira, BA	1
Boas, WV	1
Zanette, AD	1
Reis, MG	1
Goncalves, MS	1
Arlet, JB	1
Ribeil, JA	1
Chatellier, G	1
Pouchot, J	1
de Montalembert, M	1
Prié, D	1
Courbebaisse, M	1
Cumming, V	1
Ali, S	1
Forrester, T	1
Roye-Green, K	1
Reid, M	1
Reynolds, MD	1
Kaklamanis, P	1
Adeyokunnu, AA	1
Osanyintuyi, VO	1
Morgan, AG	2
De Ceulaer, K	2
Serjeant, GR	2
Isichei, UP	1
Odonkor, PO	1
Addae, SK	1
Yamamoto, S	1
Apatu, RS	1
Choo-Kang, E	1
Wilson, WA	1
Diamond, HS	4
Meisel, AD	3
Holden, D	4
al-Ali, AK	1
Ahmed, MA	1
Qaw, FS	1
al-Fadel Saleh, M	1
al-Bashir, A	1
Nduka, N	2
Kazem, Y	1
Saleh, B	1
Bayazit, AK	1
Noyan, A	1
Aldudak, B	1
Ozel, A	1
Anarat, A	1
Kilinç, Y	1
Gali, E	1
Anarat, R	1
Dikmen, N	1
Meisel, A	1
Sharon, E	2
Cacatian, A	2
Talbott, JH	1
Gottlieb, N	1
Grendelmeier, P	1
Rodriguez, E	1
Sar, AV	1
Huisman, TH	1
el-Hazmi, MA	1
Warsy, AS	1
Olukoga, AO	1
Adewoye, HO	1
Erasmus, RT	1
Adedoyin, MA	1
Adedeji, MO	1
Ukoli, FA	1
Omodiale, P	1
Ekeke, GI	1
Liu, TZ	1
Buckalew, VM	1
Someren, A	1
Diamond, H	1
Espinoza, LR	1
Spilberg, I	1
Osterland, CK	1
Walker, BR	1
Alexander, F	1
Burkholder, GV	1
Dotin, LN	1
Thomason, WB	1
Beach, PD	1
McCollum, DE	1
Mathews, RS	1
O'NEIL, MT	1
Gold, MS	1
Williams, JC	1
Spivack, M	1
Grann, V	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Chronobiology and Chronopharmacology to Prevent Sickle Cell Kidney Disease[NCT02373241]	Phase 2	1 participants (Actual)	Interventional	2015-04-30	Terminated (stopped due to Estimated GFR was determined not to be a reliable endpoint for this study. We identified significant variabilty in annual eGFR that it became inappropriate to randomize to a medication but use EGFR as the primary endpoint.)
Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients With Sickle Cell Anemia[NCT00011648]		986 participants (Actual)	Observational	2008-02-19	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Outcome 1a. Document the rate of acceptance (quantitative) and reasons for acceptance/rejection (qualitative) in a randomized trial of trial of losartan for SCD patients with abnormal nocturnal blood pressures.~Outcome 1b. Identify the adherence rate to losartan during a randomized three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure.~Outcome 1c. Determine the adherence rate to study procedures among participants enrolled in a three year trial of losartan for SCD patients (n=40) with abnormal nocturnal blood pressure." (NCT02373241)
Timeframe: 5 yrs

Feasibility as Measured by the Number of Patients With Improvement in Nocturnal Blood Pressure While Receiving Losartan.

Intervention	Participants (Count of Participants)
Standard Blood Pressure Management	0
Experimental Blood Pressure Management	1

As a feasibility trial, the effect of losartan on lowering nocturnal hypertension will be monitored to identify the difference in nocturnal BP improvement between the two treatment arms, and within group standard deviation of BP (NCT02373241)
Timeframe: 5 years

Number of Patients With Incident Hypertension

Intervention	Participants (Count of Participants)
Experimental Blood Pressure Management	1

We will prospectively evaluate the incidence of hypertension (Clinic BP in pts >5yrs and ABPM in pts >10 yrs) and role of blood and urine biomarkers (pts >5ys) among participants with HbSS or SB0 thalassemia (expected cohort n=200) over 5 yrs. We identified 20 participants (34%) with incident hypertension but randomized one to the study. The study was terminated as the eGFR was determined not to be a reliable endpoint in pediatric sickle cell. (NCT02373241)
Timeframe: 5 yrs

Article	Year
Gout and hyperuricemia associated with sickle-cell anemia. Seminars in arthritis and rheumatism, 1983, Volume: 12, Issue:4 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arthritis; Female; Gout; Hemolysis; Humans; Male; Middle Age	1983
Osteoarticular manifestations in sickle-cell disorders. Clinical rheumatology, 1984, Volume: 3, Issue:4 Topics: Anemia, Sickle Cell; Arterial Occlusive Diseases; Bone Diseases; Hemoglobin SC Disease; Humans; Join	1984
Renal manifestations of sickle cell disease. Archives of internal medicine, 1974, Volume: 133, Issue:4 Topics: Acid-Base Equilibrium; Age Factors; Anemia, Sickle Cell; Capillaries; Dilatation; Erythrocytes, Abno	1974

Article	Year
Hyperuricemia is associated with a lower glomerular filtration rate in pediatric sickle cell disease patients. Pediatric nephrology (Berlin, Germany), 2020, Volume: 35, Issue:5 Topics: Adolescent; Albuminuria; Anemia, Sickle Cell; Blood Transfusion; Child; Cohort Studies; Cross-Sectio	2020
Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemia. Pediatric nephrology (Berlin, Germany), 2017, Volume: 32, Issue:9 Topics: Adolescent; Adult; Anemia, Sickle Cell; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Child	2017
Renal function in children suffering from sickle cell disease: challenge of early detection in highly resource-scarce settings. PloS one, 2014, Volume: 9, Issue:5 Topics: Anemia, Sickle Cell; Blood Pressure; Child; Counseling; Creatinine; Democratic Republic of the Congo	2014
Gout and sickle cell disease: not all pain is sickle cell pain. British journal of haematology, 2015, Volume: 171, Issue:5 Topics: Acute Disease; Adult; Age of Onset; Aged; Aged, 80 and over; Anemia, Sickle Cell; Female; Gout; Hemo	2015
Increased oxidative stress alters nucleosides metabolite levels in sickle cell anemia. Redox report : communications in free radical research, 2017, Volume: 22, Issue:6 Topics: Adult; Anemia, Sickle Cell; Antioxidants; Catalase; Female; Glutathione; Humans; Hypoxanthine; Lipid	2017
Mutation -538 T/C in bone morphogenetic protein 4 do not increase the risk in sickle-cell disease with orthopedic complications but strongly associated with increased LDH and uric acid level in Indian patients from Chhattisgarh and Jharkhand states. Clinica chimica acta; international journal of clinical chemistry, 2010, May-02, Volume: 411, Issue:9-10 Topics: Anemia, Sickle Cell; Bone Diseases; Bone Morphogenetic Protein 4; Calcium; Genotype; Hemoglobins; He	2010
Increased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome. Cytokine, 2011, Volume: 56, Issue:2 Topics: Adolescent; Adult; Anemia, Sickle Cell; Cell Adhesion Molecules; Cross-Sectional Studies; Endotheliu	2011
[Hyperuricemia in sickle cell disease in France]. La Revue de medecine interne, 2012, Volume: 33, Issue:1 Topics: Adolescent; Adult; Aged; Anemia, Sickle Cell; Female; France; Gout; Humans; Hyperuricemia; Male; Mid	2012
Asymptomatic bacteriuria in sickle cell disease: a cross-sectional study. BMC infectious diseases, 2006, Mar-15, Volume: 6 Topics: Adult; Age Factors; Anemia, Sickle Cell; Bacteriuria; Cohort Studies; Cross-Sectional Studies; Femal	2006
Serum uric acid status of Nigerian children with sickle cell disease. East African medical journal, 1984, Volume: 61, Issue:2 Topics: Abdominal Neoplasms; Adolescent; Anemia, Sickle Cell; Burkitt Lymphoma; Child; Child, Preschool; Fem	1984
Glomerular function and hyperuricaemia in sickle cell disease. Journal of clinical pathology, 1984, Volume: 37, Issue:9 Topics: Adolescent; Adult; Aged; Anemia, Sickle Cell; Creatinine; Female; Humans; Kidney Function Tests; Kid	1984
Hyperuricaemia in sickle cell disease. Tropical and geographical medicine, 1984, Volume: 36, Issue:4 Topics: Anemia, Sickle Cell; Child; Child, Preschool; Hematocrit; Humans; Infant; Nigeria; Uric Acid	1984
Effect of dietary nitrogen on urinary excretion of non-protein nitrogen in adolescent sickle cell patients. Human nutrition. Clinical nutrition, 1984, Volume: 38, Issue:1 Topics: Adolescent; Ammonia; Anemia, Sickle Cell; Creatinine; Diet; Humans; Male; Nitrogen; Urea; Uric Acid	1984
Serum urate concentrations in homozygous sickle cell disease. Journal of clinical pathology, 1981, Volume: 34, Issue:9 Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Female; Humans; Male; Middle Aged; Sex Factors; Uric	1981
The natural history of urate overproduction in sickle cell anemia. Advances in experimental medicine and biology, 1980, Volume: 122A Topics: Adolescent; Adult; Age Factors; Anemia, Sickle Cell; Child; Child, Preschool; Female; Glomerular Fil	1980
Uric acid, creatinine and urea in normal, glucose-6-phosphate dehydrogenase-deficient and Hb SS Saudi subjects. Acta haematologica, 1995, Volume: 94, Issue:2 Topics: Anemia, Sickle Cell; Creatinine; Glucosephosphate Dehydrogenase Deficiency; Humans; Saudi Arabia; Si	1995
Variation in serum electrolytes and enzyme concentrations in patients with sickle cell disease. Journal of clinical pathology, 1995, Volume: 48, Issue:7 Topics: Adolescent; Adult; Anemia, Sickle Cell; Bilirubin; Calcium; Child; Child, Preschool; Female; Hemoglo	1995
Renal function in children with sickle cell anemia. Clinical nephrology, 2002, Volume: 57, Issue:2 Topics: Anemia, Sickle Cell; Blood Urea Nitrogen; Child; Creatinine; Female; Glomerular Filtration Rate; Hum	2002
The natural history of urate overproduction in sickle cell anemia. Annals of internal medicine, 1979, Volume: 90, Issue:5 Topics: Adolescent; Adult; Anemia, Sickle Cell; Creatinine; Female; Humans; Male; Middle Aged; p-Aminohippur	1979
Classification of uricosuric states based upon response to pharmacologic inhibitors of urate transport. Advances in experimental medicine and biology, 1977, Volume: 76B Topics: Anemia, Sickle Cell; Aspirin; Biological Transport; Diatrizoate; Fanconi Syndrome; Glomerular Filtra	1977
Hyperuricosuria and increased tubular secretion of urate in sickle cell anemia. The American journal of medicine, 1975, Volume: 59, Issue:6 Topics: Adolescent; Adult; Aminohippuric Acids; Anemia, Sickle Cell; Biological Transport; Female; Glomerula	1975
Gouty arthritis in the black race. Seminars in arthritis and rheumatism, 1975, Volume: 4, Issue:3 Topics: Adult; Aged; Anemia, Sickle Cell; Arthritis; Benzothiadiazines; Black People; Colchicine; Diuretics;	1975
Long survival in sickle cell anemia. Tropical and geographical medicine, 1975, Volume: 27, Issue:1 Topics: Age Factors; Aged; Anemia, Aplastic; Anemia, Sickle Cell; Chronic Disease; Electrophoresis, Starch G	1975
Triple alpha-genes (alpha alpha alpha anti3.7) in a patient with sickle cell anaemia. Human heredity, 1992, Volume: 42, Issue:6 Topics: Adolescent; Anemia, Sickle Cell; Bilirubin; Blood Proteins; Calcium; Cholesterol; Erythrocyte Count;	1992
Maintenance of normouricaemia during adolescence in sickle-cell anaemia. Journal of tropical pediatrics, 1992, Volume: 38, Issue:4 Topics: Adolescent; Age Factors; Anemia, Sickle Cell; Child; Female; Humans; Male; Sex Factors; Uric Acid	1992
Hyperuricaemia and foetal haemoglobin levels in homozygous sickle cell disease. The Central African journal of medicine, 1987, Volume: 33, Issue:8 Topics: Adolescent; Adult; Anemia, Sickle Cell; Female; Fetal Hemoglobin; Humans; Male; Middle Aged; Uric Ac	1987
The antisickling role of uric acid in sickle cell disease. Tropical and geographical medicine, 1987, Volume: 39, Issue:2 Topics: Adolescent; Adult; Age Factors; Anemia, Sickle Cell; Antisickling Agents; Child; Child, Preschool; E	1987
Hyperuricemia associated with sickle-cell anemia may compensate for chronic antioxidant deficiency. Clinical chemistry, 1986, Volume: 32, Issue:3 Topics: Adult; Anemia, Sickle Cell; Antioxidants; Erythrocytes; Female; Humans; Male; Uric Acid	1986
Renal handling of uric acid in sickle cell anemia. Advances in experimental medicine and biology, 1974, Volume: 41 Topics: Adolescent; Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Creatinine; Female; Humans; Kidney Tubu	1974
Joint manifestations of sickle cell disease. Medicine, 1974, Volume: 53, Issue:4 Topics: Adolescent; Adult; Anemia, Sickle Cell; Arthritis; Bone and Bones; Child; Child, Preschool; Erythroc	1974
Uric acid excretion in sickle cell anemia. JAMA, 1971, Jan-11, Volume: 215, Issue:2 Topics: Adolescent; Adult; Age Factors; Anemia, Sickle Cell; Creatinine; Female; Hemolysis; Humans; Lactates	1971
Unexplained hematuria. How extensive should the evaluation be? JAMA, 1969, Dec-01, Volume: 210, Issue:9 Topics: Anemia, Sickle Cell; Angiography; Arteriovenous Fistula; Biopsy; Cystoscopy; Glomerulonephritis; Hem	1969
Aseptic necrosis of the femoral head: associated diseases and evaluation of treatment. Southern medical journal, 1970, Volume: 63, Issue:3 Topics: Adult; Age Factors; Anemia, Sickle Cell; Bone Diseases; Female; Femoral Fractures; Femur Head; Fluor	1970
Sickle cell anemia and hyperuricemia. JAMA, 1968, Nov-11, Volume: 206, Issue:7 Topics: Anemia, Sickle Cell; Erythropoiesis; Female; Gout; Humans; Middle Aged; Uric Acid	1968

uric acid and HbS Disease