Compounds > uric acid
Page last updated: 2024-10-20

uric acid and Genetic Predisposition

uric acid has been researched along with Genetic Predisposition in 177 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
"Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout."8.84Control of renal uric acid excretion and gout. ( Kamatani, N; Taniguchi, A, 2008)
"A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, and European and African Americans; however, less is known about these associations in other populations."7.79Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study. ( Best, LG; Brown-Gentry, KD; Cole, SA; Crawford, DC; Deelman, E; Fornage, M; Franceschini, N; Gaffo, AL; Glenn, KR; Heiss, G; Jenny, NS; Jorgensen, NW; Kao, WH; Kottgen, A; Li, Q; Liu, K; Matise, TC; North, KE; Spencer, KL; Umans, JG; Voruganti, VS; Zhang, L, 2013)
" This study sought to determine the association between the novel G109T polymorphism in SLC22A12 with serum uric acid and the development of metabolic syndrome in Korean male subjects."7.78G109T polymorphism of SLC22A12 gene is associated with serum uric acid level, but not with metabolic syndrome. ( Ahn, YC; Choe, JY; Her, M; Jang, WC; Kim, SK; Nam, YH; Park, SH; Park, SM; Yoon, IK, 2012)
"Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and Blacks."7.76The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people. ( Folsom, AR; Iso, H; Kitamura, A; Köttgen, A; Tanigawa, T; Yamagishi, K, 2010)
"Uric acid levels and microsatellite markers were assayed in the Genetic Epidemiology Network of Arteriopathy (GENOA) cohort (1075 whites and 1333 blacks) and the Hypertension Genetic Epidemiology Network (HyperGEN) cohort (1542 whites and 1627 blacks)."7.75Genome-wide linkage analysis for uric acid in families enriched for hypertension. ( Asmann, Y; Boerwinkle, E; Fridley, BL; Hunt, SC; Mosley, TH; Pankow, JS; Rule, AD; Turner, ST, 2009)
"Increased serum uric acid (SUA) or hyperuricemia, a risk factor for gout, renal and cardiovascular diseases, is caused by either increased production or decreased excretion of uric acid or a mix of both."5.19Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. ( Cole, SA; Comuzzie, AG; Franceschini, N; Haack, K; Laston, S; MacCluer, JW; North, KE; Umans, JG; Voruganti, VS, 2014)
"The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on."5.01The effect of polymorphism of uric acid transporters on uric acid transport. ( Ci, X; Cui, T; Li, Y; Liu, C; Liu, R; Sun, Y; Wang, Z; Wu, W; Yi, X; Zhao, F, 2019)
"Gout is a common rheumatic disease in humans which is characterized by elevation in serum uric acid levels, and deposition of uric acid crystals in the joint."4.85Recent insights into the pathogenesis of hyperuricaemia and gout. ( Ralston, SH; Riches, PL; Wright, AF, 2009)
"Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout."4.84Control of renal uric acid excretion and gout. ( Kamatani, N; Taniguchi, A, 2008)
" Hyperuricemia is the hallmark of developing gout and mostly caused by uric acid underexcretion."3.96The prevalence of the gout-associated polymorphism rs2231142 G>T in ABCG2 in a pregnant female Filipino cohort. ( Prom-Wormley, E; Roman, Y; Tiirikainen, M, 2020)
"The urate transporter-1 (URAT1) is crucial in developing hyperuricemia via reabsorption of uric acid in renal tubules, and its function is regulated by several single nucleotide polymorphisms (SNPs) within SLC22A12 gene encoding URAT1."3.91The association between genotypes of urate transporter-1, Serum uric acid, and mortality in the community-based population: the Yamagata (Takahata) Study. ( Ichikawa, K; Ishizawa, K; Kayama, T; Kon, S; Konta, T; Sato, H; Ueno, Y; Watanabe, M; Yamashita, H, 2019)
"Three SNPs, URAT1 rs11231825, GLUT9 rs16890979 and ABCG2 rs2231142, previously associated in our population with hyperuricemia and gout, were analyzed in 27 patients with HPRT deficiency treated with allopurinol for at least 5 years."3.88GLUT9 influences uric acid concentration in patients with Lesch-Nyhan disease. ( Puig, JG; Torres, RJ, 2018)
"The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia."3.88Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders. ( Cheng, X; Cui, L; Hou, X; Jia, Z; Li, C; Li, X; Liu, Z; Lu, J; Ma, L; Mi, QS; Ren, W; Sun, R; Tian, Z; Wang, C; Wang, X; Xin, Y; Yuan, X; Zhang, K, 2018)
"Gout is a common inflammation disease resulting from an increase in serum uric acid."3.81Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population. ( Dong, Z; He, H; Ji, H; Jin, L; Ma, Y; Pang, Y; Qian, Q; Wang, J; Wang, X; Xu, X; Yang, C; Yang, Y; Zhao, D; Zhou, J; Zou, H, 2015)
"ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is identified as a high-capacity urate exporter, and its dysfunction has an association with serum uric acid levels and gout/hyperuricemia risk."3.80ABCG2 dysfunction increases the risk of renal overload hyperuricemia. ( Chiba, T; Hosoya, T; Ichida, K; Matsuo, H; Nakamura, T; Nakashima, H; Nakayama, A; Sakiyama, M; Sakurai, Y; Shimizu, S; Shimizu, T; Shinomiya, N; Takada, T; Takada, Y, 2014)
"A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, and European and African Americans; however, less is known about these associations in other populations."3.79Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study. ( Best, LG; Brown-Gentry, KD; Cole, SA; Crawford, DC; Deelman, E; Fornage, M; Franceschini, N; Gaffo, AL; Glenn, KR; Heiss, G; Jenny, NS; Jorgensen, NW; Kao, WH; Kottgen, A; Li, Q; Liu, K; Matise, TC; North, KE; Spencer, KL; Umans, JG; Voruganti, VS; Zhang, L, 2013)
"Gout is a common disease caused by hyperuricemia, which shows elevated serum uric acid (SUA) levels."3.79Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. ( Chiba, T; Hamajima, N; Hishida, A; Ichida, K; Inoue, K; Kato, Y; Kawai, S; Matsuo, H; Nakamura, T; Nakashima, H; Nakayama, A; Ogata, H; Sakiyama, M; Sakurai, Y; Shimizu, S; Shimizu, T; Shinomiya, N; Takada, T; Takada, Y; Ushiyama, C; Wakai, K, 2013)
"Val142Leu) in PRPS1 in a patient with uric acid overproduction without gout but with developmental delay, hypotonia, hearing loss, and recurrent respiratory infections."3.78Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I. ( Christodoulou, J; de Brouwer, AP; Duley, J; Friedman, NR; Kuilenburg, AB; Moran, R; Nabuurs, SB; Retno-Fitri, A; Roelofsen, J; van Bokhoven, H; Yntema, HG, 2012)
" This study sought to determine the association between the novel G109T polymorphism in SLC22A12 with serum uric acid and the development of metabolic syndrome in Korean male subjects."3.78G109T polymorphism of SLC22A12 gene is associated with serum uric acid level, but not with metabolic syndrome. ( Ahn, YC; Choe, JY; Her, M; Jang, WC; Kim, SK; Nam, YH; Park, SH; Park, SM; Yoon, IK, 2012)
"Several genome-wide association studies (GWASs) have reported associations between single nucleotide polymorphisms (SNPs) and uric acid concentrations or gout in a number of different ethnic populations."3.78Association between gout and polymorphisms in GCKR in male Han Chinese. ( Chu, N; Han, L; Li, C; Liu, S; Ma, X; Meng, D; Miao, Z; Wang, B; Wang, J; Zhang, K, 2012)
"Recent genome-wide association studies showed that serum uric acid (SUA) levels relate to ABCG2/BCRP gene, which locates in a gout-susceptibility locus revealed by a genome-wide linkage study."3.77ABCG2/BCRP dysfunction as a major cause of gout. ( Hosoya, T; Ichida, K; Matsuo, H; Nakamura, T; Nakayama, A; Shinomiya, N; Suzuki, H; Takada, T, 2011)
"In contrast to large GWA studies based on thousands of individuals and large meta-analyses combining GWAS results, we analyzed a small case/control sample for uric acid nephrolithiasis."3.77Application of a new method for GWAS in a related case/control sample with known pedigree structure: identification of new loci for nephrolithiasis. ( Bonerba, B; Caruso, MR; Casu, G; Casula, S; Concas, MP; Deiana, I; Forabosco, P; Maestrale, GB; Mele, C; Persico, I; Pirastu, M; Pistidda, P; Sassu, A; Thornton, T; Tore, S; Usai, P, 2011)
"Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and Blacks."3.76The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people. ( Folsom, AR; Iso, H; Kitamura, A; Köttgen, A; Tanigawa, T; Yamagishi, K, 2010)
"The results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population."3.76[Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population]. ( Chang, J; Guo, Y; Li, N; Luo, W; Wang, H; Yan, Z; Yang, J; Zhang, J; Zhou, L, 2010)
" Multivariate logistic regression analysis showed that the OR of having hyperuricemia at the 6-year followup was significantly associated with the Arg64 allele, after adjusting for age, weight gain, baseline levels of triglycerides, serum uric acid, and insulin resistance (OR 3."3.76Trp64Arg polymorphism of the ADRB3 gene predicts hyperuricemia risk in a population from southern Spain. ( de la Cruz Almaraz, M; García-Fuentes, E; Gómez-Zumaquero, JM; Martín-Núñez, GM; Morcillo, S; Rojo-Martínez, G; Ruiz de Adana, M; Soriguer, F, 2010)
"Uric acid levels and microsatellite markers were assayed in the Genetic Epidemiology Network of Arteriopathy (GENOA) cohort (1075 whites and 1333 blacks) and the Hypertension Genetic Epidemiology Network (HyperGEN) cohort (1542 whites and 1627 blacks)."3.75Genome-wide linkage analysis for uric acid in families enriched for hypertension. ( Asmann, Y; Boerwinkle, E; Fridley, BL; Hunt, SC; Mosley, TH; Pankow, JS; Rule, AD; Turner, ST, 2009)
"Results from this study suggest that mutation of 5-MTHFR C677T contributes to the higher uric acid levels in both males and females and may be a risk factor for hyperuricemia."3.74Association of methylenetetrahydrofolate reductase (C677T) polymorphism with hyperuricemia. ( Al-Shboul, QM; Aminzadeh, MA; Golbahar, J; Kassab, S; Rezaian, GR, 2007)
"family history of T2DM on the maternal side increased both systolic blood pressure and serum uric acid level in probands, without modification in their insulin sensitivity."3.70Maternal effect of Type 2 diabetes mellitus on insulin sensitivity and metabolic profile in healthy young Mexicans. ( González-Ortiz, M; Martínez-Abundis, E, 1999)
"Hyperuricemia and gout are common conditions that have long been known to have a heritable component."2.43Genetic factors associated with gout and hyperuricemia. ( Bleyer, AJ; Hart, TC, 2006)
" Moreover, the PRS also revealed a dose-response trend between AH rates and quartile scores."1.91Genetic contributions to female gout and hyperuricaemia using genome-wide association study and polygenic risk score analyses. ( Chang, JG; Chang, SJ; Chang, YS; Chen, YC; Chung, CC; Huang, CM; Lin, CY; Liu, TY; Tsai, FJ, 2023)
"Gout is the most common inflammatory rheumatic disease and elevated levels of serum urate (SU) are the main cause for its development."1.91Relationship between rs4349859 and rs116488202 polymorphisms close to MHC-I region and serum urate levels in patients with gout. ( Fernández-Torres, J; Martínez-Flores, K; Martínez-Nava, GA; Ruíz-Dávila, X; Sánchez-Sánchez, R; Zamudio-Cuevas, Y, 2023)
"Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status."1.72Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study. ( Chang, JG; Chang, SJ; Chang, YS; Chen, YC; Chung, CC; Huang, CM; Lin, CY; Liu, TY; Tsai, FJ, 2022)
"In the reverse direction analysis, genetic predisposition to both urate and gout were not associated with PA being investigated."1.72Genetically predicted physical activity is associated with lower serum urate concentrations. ( Chen, D; Guan, Y; Li, Y; Meng, L; Qian, Q; Wang, T; Wei, J, 2022)
"In the reverse direction analysis, genetic predisposition to both urate and gout were not associated with T2D or any of 4 glycemic traits being investigated."1.62Genetic Predisposition to Type 2 Diabetes and Insulin Levels Is Positively Associated With Serum Urate Levels. ( Fan, J; Li, Y; Sun, L; Tse, LA; Yang, J; Zhu, J, 2021)
"Gout and hyperuricemia are essentially specific to humans and other higher primates, with varied prevalence across ancestral groups."1.62Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. ( Bixley, M; Cadzow, M; Choi, HK; Dalbeth, N; Guo, H; He, M; Hu, H; Li, C; Li, Z; Major, TJ; Markie, D; Merriman, TR; Phipps-Green, A; Shi, Y; Stamp, LK; Takei, R; Wei, WH, 2021)
"Gout is characterised by severe interleukin (IL)-1-mediated joint inflammation induced by monosodium urate crystals."1.56Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout. ( Arts, P; Cavalli, G; Cleophas, MC; Crișan, TO; Dagna, L; Dalbeth, N; Dinarello, CA; Eisenmesser, EZ; Gilissen, C; Hindmarsh, JH; Hoischen, A; Jansen, TLTA; Janssen, M; Joosten, LA; Kim, S; Klück, V; Lelieveld, S; Merriman, TR; Netea, MG; Riches, P; Shaukat, A; Stamp, LK; Steehouwer, M; Tausche, AK; Van de Veerdonk, FL; van de Vorst, M; van Deuren, RC, 2020)
"A family history of urolithiasis is associated with a more than doubling of urolithiasis risk, and a twin study estimating 56% heritability of the condition suggests a pivotal role for host genetic factors."1.51Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. ( Iwasaki, M; Kamatani, Y; Kohri, K; Kubo, M; Matsuda, K; Matsuo, K; Mikami, H; Momozawa, Y; Murakami, Y; Naito, M; Ogishima, S; Satoh, M; Sawada, N; Shimizu, A; Suzuki, K; Takahashi, A; Tanikawa, C; Terao, C; Tsugane, S; Usami, M; Wakai, K; Yamaji, T; Yasui, T; Yu, ASL, 2019)
"Gout is one of the most common inflammatory arthritis in Malaysia."1.48Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set. ( Amanda Jane, PG; Mahfudzah, A; Nazihah, MY; Tan, HL; Tony Richard, M; Wan Rohani, WT; Wan Syamimee, WG, 2018)
"Gout is a multifactorial disease characterized by acute inflammatory arthritis, and it is caused as a consequence of hyperuricemia."1.48A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility. ( Higashino, T; Hishida, A; Imaki, J; Kawaguchi, M; Komatsu, M; Matsuo, H; Nakashima, H; Nakatochi, M; Nakayama, A; Okada, Y; Ooyama, H; Sakiyama, M; Shimizu, S; Shinomiya, N; Tadokoro, S, 2018)
"Gout is a chronic disease resulting from elevated serum urate (SU)."1.46Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population. ( Chen, J; Cheng, X; Cui, L; Han, L; Hou, X; Ji, J; Jia, Z; Li, C; Li, X; Li, Z; Liu, T; Liu, Z; Lu, D; Lu, J; Ma, L; Mi, QS; Ren, W; Shi, Y; Wang, C; Wang, X; Xin, Y; Yu, Q; Yuan, X; Zhang, K; Zhou, Z, 2017)
"Hyperuricemia is highly heritable and is associated with sex and body weight."1.46Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population. ( Cheng, ST; Hsu, LA; Ko, YL; Su, CW; Teng, MS; Wu, S, 2017)
"Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout."1.46Effects of multiple genetic loci on the pathogenesis from serum urate to gout. ( Dong, Z; He, H; Ji, H; Jiang, S; Jin, L; Li, Y; Ma, Y; Pang, Y; Wang, J; Wang, X; Wang, Y; Xu, X; Yang, C; Yang, Y; Zhao, D; Zhou, J; Zou, H, 2017)
"Gout/hyperuricemia is a common multifactorial disease having typical environmental risks."1.40Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors. ( Abe, J; Akashi, A; Chiba, T; Hosoya, T; Ichida, K; Kawai, S; Kawamura, Y; Matsuo, H; Nakamura, T; Nakaoka, H; Nakashima, H; Nakayama, A; Oikawa, Y; Okada, R; Sakiyama, M; Sakurai, Y; Shichijo, Y; Shimizu, S; Shinomiya, N; Suzuki, H; Takada, T; Takada, Y; Tamura, T; Wakai, K, 2014)
"Gout is a common disease resulting from hyperuricemia which causes acute arthritis."1.40Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility. ( Chiba, T; Hamajima, N; Ichida, K; Inoue, H; Kanai, Y; Makino, T; Matsuo, H; Morita, E; Naito, M; Nakamura, T; Nakayama, A; Sakiyama, M; Sakurai, Y; Sato, J; Satoh, T; Shimizu, S; Shimizu, T; Shimono, K; Shinomiya, N; Suzuki, H; Takada, T; Takada, Y; Tatsukawa, S; Wakai, K, 2014)
"Hyperuricemia has been shown to be a strong correlate of hypertension in children."1.39Serum uric acid and blood pressure in children at cardiovascular risk. ( Antolini, L; Brambilla, P; Galbiati, S; Genovesi, S; Giussani, M; Mastriani, S; Pontremoli, R; Stella, A; Valsecchi, MG; Viazzi, F, 2013)
"Hyperuricemia was defined as SUA equal to 7 mg/dL or over."1.39No association between MTHFR C677T and serum uric acid levels among Japanese with ABCG2 126QQ and SLC22A12 258WW. ( Hamajima, N; Higashibata, T; Hinohara, Y; Kawai, S; Matsuo, H; Mori, A; Morita, E; Naito, M; Okada, R; Tamura, T; Wakai, K; Yin, G, 2013)
"Urinary tract infections (UTIs) were detected in 65."1.39Urinary stone disease in the first year of life: is it dangerous? ( Alpay, H; Bıyıklı, N; Gokce, I; Özen, A, 2013)
"163 children, 116 with type 1 diabetes and 47 healthy controls, at the age 6-19 years were enrolled to the study."1.39The association between gene polymorphisms of glutathione S-transferase T1/M1 and type 1 diabetes in Slovak children and adolescents. ( Babusíková, E; Ciljaková, M; Durdík, P; Michnová, Z; Turcan, T; Vojtková, J, 2013)
"Urolithiasis is one of the commonest problems in pediatric nephrology."1.36Clinical manifestations and etiology of renal stones in children less than 14 years age. ( Heidari, A; Sepahi, MA; Shajari, A, 2010)
"Gout is the most common autoinflammatory arthritis characterized by elevated serum urate and recurrent attacks of intra-articular crystal deposition of monosodium urate (MSU)."1.35NALP3 inflammasome functional polymorphisms and gout susceptibility. ( Li, CG; Meng, DM; Mi, QS; Miao, ZM; Wang, YG; Yan, SL; Zhao, SH; Zhou, L, 2009)
"Uric acid nephrolithiasis (UAN) is a common disease with an established genetic component that presents a complex mode of inheritance."1.32Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. ( Cardia, F; Casu, G; Casula, S; Deiana, I; Esposito, T; Falchi, M; Fattorini, M; Forabosco, P; Gianfrancesco, F; Maninchedda, G; Melis, P; Ombra, MN; Pirastu, M; Vaccargiu, S, 2003)
"Lifetime risk for nephrolithiasis is approximately 10% in Western populations, and uric acid stones account for 5%-10% of all stones, depending on climatic, dietary, and ethnic differences."1.31Identification of a new candidate locus for uric acid nephrolithiasis. ( Angius, A; Casu, G; Casula, S; Colussi, G; Forabosco, P; Maestrale, G; Melis, P; Ombra, MN; Petretto, E; Pirastu, M; Usai, E, 2001)

Research

Studies (177)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (1.13)18.2507
2000's33 (18.64)29.6817
2010's113 (63.84)24.3611
2020's29 (16.38)2.80

Authors

AuthorsStudies
Vargas-Morales, JM2
Guevara-Cruz, M2
Aradillas-García, C2
G Noriega, L2
Tovar, A2
Alegría-Torres, JA2
Leask, MP2
Merriman, TR16
Tin, A4
Schlosser, P1
Matias-Garcia, PR1
Thio, CHL2
Joehanes, R1
Liu, H2
Yu, Z2
Weihs, A1
Hoppmann, A2
Grundner-Culemann, F1
Min, JL1
Kuhns, VLH1
Adeyemo, AA2
Agyemang, C1
Ärnlöv, J2
Aziz, NA1
Baccarelli, A1
Bochud, M2
Brenner, H1
Bressler, J1
Breteler, MMB1
Carmeli, C1
Chaker, L1
Coresh, J2
Corre, T2
Correa, A1
Cox, SR1
Delgado, GE1
Eckardt, KU3
Ekici, AB2
Endlich, K2
Floyd, JS1
Fraszczyk, E1
Gao, X2
Gelber, AC1
Ghanbari, M1
Ghasemi, S3
Gieger, C2
Greenland, P1
Grove, ML1
Harris, SE1
Hemani, G1
Henneman, P1
Herder, C1
Horvath, S1
Hou, L1
Hurme, MA1
Hwang, SJ3
Kardia, SLR1
Kasela, S1
Kleber, ME2
Koenig, W2
Kooner, JS3
Kronenberg, F3
Kühnel, B2
Ladd-Acosta, C1
Lehtimäki, T2
Lind, L1
Liu, D1
Lloyd-Jones, DM1
Lorkowski, S1
Lu, AT1
Marioni, RE1
März, W2
McCartney, DL1
Meeks, KAC1
Milani, L1
Mishra, PP2
Nauck, M2
Nowak, C1
Peters, A2
Prokisch, H1
Psaty, BM3
Raitakari, OT2
Ratliff, SM1
Reiner, AP1
Schöttker, B1
Schwartz, J1
Sedaghat, S3
Smith, JA1
Sotoodehnia, N1
Stocker, HR1
Stringhini, S1
Sundström, J1
Swenson, BR1
van Meurs, JBJ1
van Vliet-Ostaptchouk, JV1
Venema, A1
Völker, U2
Winkelmann, J1
Wolffenbuttel, BHR1
Zhao, W1
Zheng, Y2
Loh, M1
Snieder, H2
Waldenberger, M2
Levy, D1
Akilesh, S1
Woodward, OM5
Susztak, K2
Teumer, A3
Köttgen, A7
Guan, Y1
Wei, J1
Meng, L1
Li, Y16
Wang, T4
Chen, D2
Qian, Q2
Sandoval-Plata, G1
Morgan, K1
Abhishek, A1
Lin, CY2
Chang, YS2
Liu, TY2
Huang, CM2
Chung, CC2
Chen, YC2
Tsai, FJ3
Chang, JG3
Chang, SJ3
Lupi, AS1
Sumpter, NA1
O'Sullivan, J2
Fadason, T2
de Los Campos, G1
Reynolds, RJ2
Vazquez, AI2
Lin, Y1
Ma, B1
Yang, Y6
Chen, Y8
Huang, J2
Li, W3
Yu, X1
Liang, L1
Fernández-Torres, J2
Zamudio-Cuevas, Y2
Martínez-Nava, GA2
Martínez-Flores, K2
Ruíz-Dávila, X1
Sánchez-Sánchez, R1
Lin, CT1
Chen, IC1
Chen, YJ1
Lin, YC1
Chang, JC1
Wang, TJ1
Huang, WN1
Chen, YH2
Lin, CH1
Chen, YM1
Kou, I1
Otomo, N1
Takeda, K1
Momozawa, Y2
Lu, HF1
Kubo, M6
Kamatani, Y4
Ogura, Y1
Takahashi, Y1
Nakajima, M2
Minami, S1
Uno, K1
Kawakami, N1
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de la Cruz Almaraz, M1
Soriguer, F1
Sepahi, MA1
Heidari, A1
Shajari, A1
Low, WW1
Uhl, JM1
Kass, PH1
Ruby, AL1
Westropp, JL1
Jurecka, A1
Krijt, J1
Gradowska, W1
Tylki-Szymanska, A1
Li, N1
Guo, Y1
Luo, W1
Chang, J1
McCue, J1
Langston, C1
Palma, D1
Gisselman, K1
Yamagishi, K1
Tanigawa, T1
Kitamura, A1
Folsom, AR1
Iso, H1
Loomba, R1
Rao, F1
Khandrika, S1
Ziegler, MG1
Brenner, DA1
O'Connor, DT1
Johri, N1
Cooper, B1
Robertson, W1
Choong, S1
Rickards, D1
Unwin, R1
Karmi, N1
Safra, N2
Young, A1
Bannasch, DL2
Jutabha, P1
Anzai, N1
Kitamura, K1
Kaneko, S1
Yan, K1
Shimada, H1
Kimura, T1
Katada, T1
Fukutomi, T1
Tomita, K1
Seki, G1
Fujita, T1
Yamada, A1
Wempe, MF1
Endou, H1
Sakurai, H1
Piret, SE1
Danoy, P1
Dahan, K2
Reed, AA1
Pryce, K1
Wong, W1
Müller, T1
Kotanko, P1
Lhotta, K1
Brown, MA1
Thakker, RV1
Sampat, R1
Fu, R1
Larovere, LE1
Ceballos-Picot, I1
Fischbach, M1
de Kremer, R1
Schretlen, DJ1
Jinnah, HA1
Akl, KF1
Tore, S1
Casula, S4
Casu, G3
Pistidda, P1
Persico, I1
Sassu, A1
Maestrale, GB1
Mele, C1
Caruso, MR1
Bonerba, B1
Usai, P1
Deiana, I2
Thornton, T1
Forabosco, P3
Jang, WC1
Nam, YH1
Ahn, YC1
Park, SM1
Yoon, IK1
Park, SH1
Her, M1
Liu, CT1
Lu, X1
Shriner, D1
Semmo, M1
Akylbekova, EL1
Wyatt, SB1
Palmer, C1
Reilly, M1
Shlipak, MG1
Siscovick, D1
Rotimi, CN1
Flessner, MF1
Köttgen, M1
Cupples, LA1
Chiou, SJ1
Lee, SS1
Tsai, YS1
Bollée, G1
Flamant, M1
Morinière, V1
Pawtowski, A1
Heidet, L1
Lacombe, D1
Pirson, Y1
Antignac, C1
Knebelmann, B1
Sull, JW1
Park, EJ1
Lee, M1
Karns, R1
Zhang, G1
Sun, G1
Rao Indugula, S1
Cheng, H1
Havas-Augustin, D1
Novokmet, N1
Rudan, D1
Durakovic, Z1
Missoni, S1
Chakraborty, R1
Rudan, P1
Deka, R1
Moran, R1
Kuilenburg, AB1
Duley, J1
Nabuurs, SB1
Retno-Fitri, A1
Christodoulou, J1
Roelofsen, J1
Yntema, HG1
Friedman, NR1
van Bokhoven, H1
de Brouwer, AP1
Schmid, R1
Bastardot, F1
Marques-Vidal, P1
Liu, S1
Wang, B1
Miao, Z1
Chu, N1
Meng, D1
Ma, X2
Shin, J1
Kong, M1
Lee, C1
Bazrgar, M1
Karimi, M1
Ma, YT1
Yang, YN1
Li, XM1
Fu, ZY1
Zheng, YY1
Chen, BD1
Liu, F1
Yu, ZX1
Sim, X1
Go, MJ1
Wu, JY1
Gu, D1
Takeuchi, F2
Maeda, S1
Tsunoda, T1
Lim, SC1
Wong, TY1
Young, TL1
Aung, T1
Seielstad, M1
Teo, YY1
Kim, YJ1
Lee, JY1
Han, BG1
Kang, D1
Chen, CH1
Chang, LC1
Fann, SJ1
Mei, H1
Rao, DC1
Hixson, JE1
Katsuya, T2
Isono, M2
Ogihara, T2
Albrecht, E1
He, J1
Chen, YT1
Cho, YS1
Tai, ES1
Tanaka, T1
Léa Correa Leite, M1
Lima-Costa, MF1
Moriguchi, EH1
Yakut, S1
Cetin, Z1
Arman, M1
Akbas, H1
Manguoglu, AE1
Luleci, G1
Akiyama, K1
Ohnaka, K1
Rakugi, H1
Yamori, Y1
Takayanagi, R1
Alpay, H1
Gokce, I1
Özen, A1
Bıyıklı, N1
Le, MT1
Lobmeyer, MT1
Campbell, M1
Chapman, AB1
Gums, JG1
Gong, Y1
Johnson, JA1
Gianfrancesco, F1
Esposito, T1
Ombra, MN3
Maninchedda, G1
Fattorini, M1
Cardia, F2
Melis, P3
Falchi, M1
Maestrale, G2
Siani, A1
Russo, P1
Paolo Cappuccio, F1
Iacone, R1
Venezia, A1
Russo, O1
Barba, G1
Iacoviello, L1
Strazzullo, P1
Wang, JG1
Wang, GL1
Zhou, HF1
Zhang, WZ1
Zhan, YM1
Zhu, DL1
Hong, YS1
Lee, MJ1
Kim, KH1
Lee, SH1
Lee, YH1
Kim, BG1
Jeong, B1
Yoon, HR1
Nishio, H1
Kim, JY1
Cameron, JS1
Simmonds, HA1
Bleyer, AJ1
Hart, TC1
Schaible, RH1
Suwazono, Y1
Kobayashi, E1
Uetani, M1
Miura, K1
Morikawa, Y1
Ishizaki, M1
Kido, T1
Nakagawa, H1
Nogawa, K1
Mente, A1
Honey, RJ1
McLaughlin, JM1
Bull, SB1
Logan, AG1
Shima, Y1
Teruya, K1
Ohta, H1
Golbahar, J1
Aminzadeh, MA1
Al-Shboul, QM1
Kassab, S1
Rezaian, GR1
Grusch, B1
Rintelen, B1
Leeb, BF1
Tzovaras, V1
Chatzikyriakidou, A1
Bairaktari, E1
Liberopoulos, EN1
Georgiou, I1
Segal, MS1
Sautin, Y1
Nakagawa, T1
Feig, DI1
Kang, DH1
Gersch, MS1
Benner, S1
Sánchez-Lozada, LG1
Spivacow, FR1
Negri, AL1
del Valle, EE1
Calviño, I1
Fradinger, E1
Zanchetta, JR1
Neureuther, K1
Wiedmann, S1
Sedlacek, K1
Baessler, A1
Fischer, M1
Weber, S1
Kaess, B1
Maenishi, O1
Ito, H1
González-Ortiz, M1
Martínez-Abundis, E1
Garg, A1
Angius, A1
Petretto, E1
Colussi, G1
Usai, E1
Torbus-Lisiecka, B1
Bukowska, H1
Jastrzebska, M1
Chelstowski, K1
Honczarenko, K1
Naruszewicz, M1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage[NCT04752293]125 participants (Anticipated)Observational2021-05-19Recruiting
Study on the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention[NCT03425708]Phase 4400 participants (Anticipated)Interventional2017-01-01Recruiting
Uric Acid and Hypertension in African Americans[NCT00241839]Phase 3150 participants (Actual)Interventional2005-08-31Completed
Influence of Food Liking of Adding Spices to Replace Dietary Sugar Using Sequential Monadic CLT Methodology[NCT03139552]150 participants (Actual)Interventional2016-10-17Completed
Influence on Food Liking of Adding Spices to Replace Dietary Sugar[NCT03134079]160 participants (Actual)Interventional2015-09-10Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure by Cuff 8-10 Weeks Minus Baseline

"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo

Interventionmm Hg (Mean)
A (Allopurinol)3.44
B (Placebo)-0.83

Change in Overall Mean BP From Those Obtained by 24 Hour Ambulatory Blood Pressure Measurements (ABPM) 8-10 Weeks Minus Baseline.

Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)

Interventionmm Hg (Mean)
A (Allopurinol)-5.9
B (Placebo)0.90

Change in Systolic Blood Pressure by Cuff After 8-10 Weeks Minus Baseline

"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo

Interventionmm Hg (Mean)
A (Allopurinol)0.21
B (Placebo)-0.95

Change in Uric Acid (UA) Levels: Baseline Less End of Treatment

Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)

Interventionmg/dl (Mean)
A (Allopurinol)2.29
B (Placebo)0.14

Overall Liking of Apple Crisp

Overall liking of apple crisp with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: Day of taste testing

Interventionscore on likert rating scale (Mean)
Full Sugar Recipe7.31
Reduced Sugar Recipe6.83
Reduced Sugar Plus Spice Recipe7.22

Overall Liking of Oatmeal

Overall liking of oatmeal with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing

Interventionscore on a likert rating scale (Mean)
Full Sugar Recipe6.84
Reduced Sugar Recipe5.70
Reduced Sugar Plus Spice Recipe6.15

Overall Liking of Tea

Overall liking of tea with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing

Interventionscore on a likert rating scale (Mean)
Full Sugar Recipe6.00
Reduced Sugar Recipe5.62
Reduced Sugar Plus Spice Recipe5.85

Ranking of Full Sugar Recipe of Apple Crisp

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking54
Second Place Ranking63
Third Place Ranking33

Ranking of Full Sugar Recipe of Oatmeal

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking88
Second Place Ranking39
Third Place Ranking21

Ranking of Full Sugar Recipe of Tea

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking66
Second Place Ranking41
Third Place Ranking42

Ranking of Reduced Sugar Plus Spice Oatmeal

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking48
Second Place Ranking60
Third Place Ranking40

Ranking of Reduced Sugar Plus Spice Recipe of Apple Crisp

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking63
Second Place Ranking44
Third Place Ranking43

Ranking of Reduced Sugar Plus Spice Recipe of Tea

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking49
Second Place Ranking50
Third Place Ranking50

Ranking of Reduced Sugar Recipe of Apple Crisp

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking33
Second Place Ranking43
Third Place Ranking74

Ranking of Reduced Sugar Recipe of Oatmeal

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking12
Second Place Ranking49
Third Place Ranking87

Ranking of Reduced Sugar Recipe of Tea

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: Day of taste testings

InterventionParticipants (Count of Participants)
First Place Ranking34
Second Place Ranking58
Third Place Ranking57

Reviews

25 reviews available for uric acid and Genetic Predisposition

ArticleYear
The genetic basis of urate control and gout: Insights into molecular pathogenesis from follow-up study of genome-wide association study loci.
    Best practice & research. Clinical rheumatology, 2021, Volume: 35, Issue:4

    Topics: Aldehyde Dehydrogenase, Mitochondrial; Follow-Up Studies; Genetic Predisposition to Disease; Genome-

2021
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
    Nature communications, 2019, 08-15, Volume: 10, Issue:1

    Topics: Adolescent; Asian People; Body Mass Index; Female; Genetic Predisposition to Disease; Genome-Wide As

2019
Sex Differences in Urate Handling.
    International journal of molecular sciences, 2020, Jun-16, Volume: 21, Issue:12

    Topics: Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Homeostasis; Humans; Hyper

2020
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Animal models of naturally occurring stone disease.
    Nature reviews. Urology, 2020, Volume: 17, Issue:12

    Topics: Animals; Biomedical Research; Calcium Oxalate; Cats; Cystine; Disease Models, Animal; Dogs; Dolphins

2020
Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.
    Hypertension (Dallas, Tex. : 1979), 2021, Volume: 77, Issue:2

    Topics: Blood Pressure; Cardiovascular Diseases; Genetic Predisposition to Disease; Humans; Mendelian Random

2021
Uric acid and cardiovascular risk: What genes can say.
    International journal of clinical practice, 2018, Volume: 72, Issue:1

    Topics: Biomarkers; Cardiovascular Diseases; Genetic Predisposition to Disease; Humans; Hyperuricemia; Mende

2018
An update on the genetics of hyperuricaemia and gout.
    Nature reviews. Rheumatology, 2018, Volume: 14, Issue:6

    Topics: Animals; Disease Progression; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Asso

2018
Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts.
    BMJ (Clinical research ed.), 2018, Oct-10, Volume: 363

    Topics: Cohort Studies; Cross-Sectional Studies; Diet; Genetic Predisposition to Disease; Gout; Humans; Unit

2018
The effect of polymorphism of uric acid transporters on uric acid transport.
    Journal of nephrology, 2019, Volume: 32, Issue:2

    Topics: Animals; Biomarkers; Genetic Predisposition to Disease; Humans; Hyperuricemia; Kidney; Membrane Tran

2019
Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.
    Communications biology, 2019, Volume: 2

    Topics: Alleles; Computational Biology; Genetic Predisposition to Disease; Genome-Wide Association Study; Ge

2019
Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption.
    Arthritis research & therapy, 2013, Nov-04, Volume: 15, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Alcohol Drinking; Carrier Proteins; Female; Genetic Predisposi

2013
Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout.
    Rheumatology international, 2016, Volume: 36, Issue:2

    Topics: Biomarkers; Case-Control Studies; Gene Frequency; Genetic Association Studies; Genetic Predispositio

2016
Can the silkworm (Bombyx mori) be used as a human disease model?
    Drug discoveries & therapeutics, 2016, Volume: 10, Issue:1

    Topics: Animals; Antiparkinson Agents; Bombyx; Disease Models, Animal; Drug Discovery; Gene Expression Profi

2016
Time to target uric acid to retard CKD progression.
    Clinical and experimental nephrology, 2017, Volume: 21, Issue:2

    Topics: Animals; Biomarkers; Disease Progression; Genetic Predisposition to Disease; Gout Suppressants; Huma

2017
Epidemiology, environmental risk factors and genetics of Parkinson's disease.
    Presse medicale (Paris, France : 1983), 2017, Volume: 46, Issue:2 Pt 1

    Topics: Age Distribution; Age of Onset; alpha-Synuclein; Caffeine; Causality; Gene-Environment Interaction;

2017
Recent insights into the pathogenesis of hyperuricaemia and gout.
    Human molecular genetics, 2009, Oct-15, Volume: 18, Issue:R2

    Topics: Animals; Genetic Predisposition to Disease; Genome-Wide Association Study; Gout; Humans; Hyperuricem

2009
Urate urolithiasis.
    Compendium (Yardley, PA), 2009, Volume: 31, Issue:10

    Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Genetic Predisposition to Disease; Risk Factors; Sp

2009
An update and practical guide to renal stone management.
    Nephron. Clinical practice, 2010, Volume: 116, Issue:3

    Topics: Age of Onset; Calcium Oxalate; Calcium Phosphates; Cross-Sectional Studies; Cystine; Diabetes Mellit

2010
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
    Human molecular genetics, 2011, Oct-15, Volume: 20, Issue:20

    Topics: Adult; Aged; Animals; Black or African American; CHO Cells; Cricetinae; Female; Genetic Loci; Geneti

2011
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
    Nature genetics, 2012, Jul-15, Volume: 44, Issue:8

    Topics: Asian People; Blood Urea Nitrogen; Cohort Studies; Creatinine; Genetic Predisposition to Disease; Ge

2012
Hereditary hyperuricemia and renal disease.
    Seminars in nephrology, 2005, Volume: 25, Issue:1

    Topics: Genetic Predisposition to Disease; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Ki

2005
Genetic factors associated with gout and hyperuricemia.
    Advances in chronic kidney disease, 2006, Volume: 13, Issue:2

    Topics: Blood Group Antigens; Genetic Markers; Genetic Predisposition to Disease; Gout; Humans; Hyperuricemi

2006
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:4

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Fructose; Genetic Predispo

2007
Control of renal uric acid excretion and gout.
    Current opinion in rheumatology, 2008, Volume: 20, Issue:2

    Topics: Genetic Predisposition to Disease; Gout; Humans; Hyperuricemia; Kidney Tubules, Proximal; Organic An

2008

Trials

4 trials available for uric acid and Genetic Predisposition

ArticleYear
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians.
    European journal of human genetics : EJHG, 2014, Volume: 22, Issue:7

    Topics: Adult; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Glomerula

2014
Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge.
    Arthritis research & therapy, 2014, Jan-30, Volume: 16, Issue:1

    Topics: Adult; Alleles; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transp

2014
Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese.
    Life sciences, 2006, Nov-02, Volume: 79, Issue:23

    Topics: Asian People; Creatinine; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genoty

2006

Other Studies

149 other studies available for uric acid and Genetic Predisposition

ArticleYear
Polymorphisms of the genes
    F1000Research, 2021, Volume: 10

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Case-Control Studies; Genetic Predispositio

2021
Polymorphisms of the genes
    F1000Research, 2021, Volume: 10

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Case-Control Studies; Genetic Predispositio

2021
Polymorphisms of the genes
    F1000Research, 2021, Volume: 10

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Case-Control Studies; Genetic Predispositio

2021
Polymorphisms of the genes
    F1000Research, 2021, Volume: 10

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Case-Control Studies; Genetic Predispositio

2021
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
    Nature communications, 2021, 12-09, Volume: 12, Issue:1

    Topics: Amino Acid Transport System y+; Cohort Studies; CpG Islands; DNA Methylation; Epigenome; Female; Gen

2021
Genetically predicted physical activity is associated with lower serum urate concentrations.
    Genes & genomics, 2022, Volume: 44, Issue:7

    Topics: Exercise; Genetic Predisposition to Disease; Genome-Wide Association Study; Gout; Humans; Mendelian

2022
Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case-control study using data from the UK Biobank.
    Rheumatology international, 2022, Volume: 42, Issue:9

    Topics: Alcohol Drinking; Biological Specimen Banks; Case-Control Studies; Genetic Predisposition to Disease

2022
Genetic contributions to female gout and hyperuricaemia using genome-wide association study and polygenic risk score analyses.
    Rheumatology (Oxford, England), 2023, 02-01, Volume: 62, Issue:2

    Topics: Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucose Transport Proteins

2023
Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models.
    G3 (Bethesda, Md.), 2022, 08-25, Volume: 12, Issue:9

    Topics: Bayes Theorem; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Hyperuricem

2022
Impaired kidney function biomarkers and risk of severe COVID-19: Analysis of population-based cohort data.
    Molecular genetics & genomic medicine, 2022, Volume: 10, Issue:11

    Topics: Adult; Albuminuria; Biomarkers; COVID-19; Cross-Sectional Studies; Cystatin C; Genetic Predispositio

2022
Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study.
    Arthritis research & therapy, 2022, 10-11, Volume: 24, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Chromosomes, Human, Pair 1; Female; Genetic

2022
Relationship between rs4349859 and rs116488202 polymorphisms close to MHC-I region and serum urate levels in patients with gout.
    Molecular biology reports, 2023, Volume: 50, Issue:5

    Topics: Genetic Predisposition to Disease; Genotype; Gout; Heterozygote; Humans; Polymorphism, Single Nucleo

2023
The
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Specimen Banks; Cas

2023
The association between genotypes of urate transporter-1, Serum uric acid, and mortality in the community-based population: the Yamagata (Takahata) Study.
    Clinical and experimental nephrology, 2019, Volume: 23, Issue:12

    Topics: Aged; Biomarkers; Female; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Hyper

2019
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
    Nature genetics, 2019, Volume: 51, Issue:10

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Cardiovascular Diseases; Cohort Studies; Ge

2019
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
    PLoS medicine, 2019, Volume: 16, Issue:10

    Topics: Adult; Aged; Bayes Theorem; Biological Specimen Banks; Cardiovascular Diseases; Cohort Studies; Como

2019
Dysfunctional missense variant of
    Annals of the rheumatic diseases, 2020, Volume: 79, Issue:1

    Topics: Adult; Asian People; Case-Control Studies; Genetic Predisposition to Disease; Gout; Humans; Hyperuri

2020
Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.
    Human molecular genetics, 2020, 04-15, Volume: 29, Issue:6

    Topics: Case-Control Studies; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association St

2020
Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus.
    Rheumatology (Oxford, England), 2020, 09-01, Volume: 59, Issue:9

    Topics: Adult; Age of Onset; ATP Binding Cassette Transporter, Subfamily G, Member 2; Europe; Female; Geneti

2020
Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout.
    Hereditas, 2020, Jan-27, Volume: 157, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Body Mass Index; Epistasis, Genetic; Geneti

2020
The prevalence of the gout-associated polymorphism rs2231142 G>T in ABCG2 in a pregnant female Filipino cohort.
    Clinical rheumatology, 2020, Volume: 39, Issue:8

    Topics: Adolescent; Adult; Alleles; Asian People; ATP Binding Cassette Transporter, Subfamily G, Member 2; B

2020
Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.
    Annals of the rheumatic diseases, 2020, Volume: 79, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Case-Control Studies; Female; Genetic Predisposition to Dis

2020
Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout.
    Arthritis research & therapy, 2020, 03-12, Volume: 22, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Disease Progression; Epistasis, Genetic; Eu

2020
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.
    BMC medical genetics, 2020, 03-17, Volume: 21, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cardiovascu

2020
Gene polymorphisms of uric acid are associated with pre-eclampsia in South Africans of African ancestry.
    Hypertension in pregnancy, 2020, Volume: 39, Issue:2

    Topics: Adult; Alleles; Black People; Case-Control Studies; Female; Genetic Predisposition to Disease; Genot

2020
Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects.
    Journal of human genetics, 2021, Volume: 66, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Evolution, Molecular; Genetic Pred

2021
Isolated sulfite oxidase deficiency: a founder mutation.
    Cold Spring Harbor molecular case studies, 2020, Volume: 6, Issue:6

    Topics: Amino Acid Metabolism, Inborn Errors; Female; Genetic Predisposition to Disease; Humans; Male; Mutat

2020
A polymorphism in the 3'-untranslated region of the matrix metallopeptidase 9 gene is associated with susceptibility to idiopathic calcium nephrolithiasis in the Chinese population.
    The Journal of international medical research, 2020, Volume: 48, Issue:12

    Topics: 3' Untranslated Regions; Adult; Asian People; Calcium; Case-Control Studies; China; Female; Gene Fre

2020
Genetic Predisposition to Type 2 Diabetes and Insulin Levels Is Positively Associated With Serum Urate Levels.
    The Journal of clinical endocrinology and metabolism, 2021, 06-16, Volume: 106, Issue:7

    Topics: Adult; Blood Glucose; Causality; Diabetes Mellitus, Type 2; Fasting; Female; Genetic Predisposition

2021
Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
    PloS one, 2021, Volume: 16, Issue:8

    Topics: Adolescent; Blood Pressure; Cardiovascular Diseases; Child; Cholesterol; Cholesterol, HDL; Female; G

2021
Genetic risk scores, sex and dietary factors interact to alter serum uric acid trajectory among African-American urban adults.
    The British journal of nutrition, 2017, Volume: 117, Issue:5

    Topics: Adult; Alcohol Drinking; Ascorbic Acid Deficiency; Black or African American; Cohort Studies; Cross-

2017
Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.
    Oncotarget, 2017, Jul-11, Volume: 8, Issue:28

    Topics: Aged; Autophagy-Related Proteins; Creatinine; Exome; Female; Genetic Predisposition to Disease; Geno

2017
Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population.
    Scientific reports, 2017, 06-22, Volume: 7, Issue:1

    Topics: Alleles; Asian People; Biomarkers; China; Female; Genetic Loci; Genetic Predisposition to Disease; G

2017
Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.
    Arthritis research & therapy, 2017, 07-05, Volume: 19, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Alcohol Drinking; Female; Gene-Environment Intera

2017
Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.
    Kidney international, 2018, Volume: 93, Issue:1

    Topics: Animals; Biomarkers; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Creatinine; Diabetes Mellit

2018
Performance of gout definitions for genetic epidemiological studies: analysis of UK Biobank.
    Arthritis research & therapy, 2017, 08-09, Volume: 19, Issue:1

    Topics: Adult; Aged; Biological Specimen Banks; Europe; Female; Genetic Predisposition to Disease; Gout; Gou

2017
A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility.
    Human cell, 2018, Volume: 31, Issue:1

    Topics: Adult; Asian People; Cell Differentiation; Gene Frequency; Genetic Association Studies; Genetic Pred

2018
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
    Molecular genetics and genomics : MGG, 2018, Volume: 293, Issue:2

    Topics: Asian People; Cohort Studies; Cross-Sectional Studies; Female; Genetic Predisposition to Disease; Ge

2018
MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.
    Annals of the rheumatic diseases, 2018, Volume: 77, Issue:7

    Topics: Adult; Arthritis; Autoimmune Diseases; Biological Specimen Banks; Celiac Disease; Female; Genetic Pr

2018
Genetic variants in two pathways influence serum urate levels and gout risk: a systematic pathway analysis.
    Scientific reports, 2018, 03-01, Volume: 8, Issue:1

    Topics: Asian People; Case-Control Studies; China; Female; Genetic Loci; Genetic Predisposition to Disease;

2018
Genome-wide association analysis identifies multiple loci associated with kidney disease-related traits in Korean populations.
    PloS one, 2018, Volume: 13, Issue:3

    Topics: Adult; Blood Urea Nitrogen; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 4; Creatinine; Fema

2018
Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility.
    Connective tissue research, 2019, Volume: 60, Issue:3

    Topics: Adult; Biological Transport; Case-Control Studies; Epistasis, Genetic; Female; Gene Frequency; Genet

2019
GLUT9 influences uric acid concentration in patients with Lesch-Nyhan disease.
    International journal of rheumatic diseases, 2018, Volume: 21, Issue:6

    Topics: Adolescent; Adult; Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biomarkers;

2018
Mediation analysis to understand genetic relationships between habitual coffee intake and gout.
    Arthritis research & therapy, 2018, 07-05, Volume: 20, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Alleles; ATP Binding Cassette Transporter, Subfam

2018
Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.
    Scientific reports, 2018, 09-04, Volume: 8, Issue:1

    Topics: Aged; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cohort Studies; Female; Genetic Predi

2018
Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels.
    Nature communications, 2018, 10-12, Volume: 9, Issue:1

    Topics: Exome; Genetic Predisposition to Disease; Glucose Transport Proteins, Facilitative; Humans; Kidney F

2018
Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set.
    The Medical journal of Malaysia, 2018, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Aged; Asian People; Case-Control Studies; Creatinine; Female; Genetic Association

2018
Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study.
    The American journal of clinical nutrition, 2019, 01-01, Volume: 109, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Ascorbic Acid; beta Carotene; Case-Control

2019
Polymorphisms of
    Medicina (Kaunas, Lithuania), 2019, Jan-07, Volume: 55, Issue:1

    Topics: Adult; Aged; Alleles; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood Pressure; Case-

2019
Higher urate in LRRK2 mutation carriers resistant to Parkinson disease.
    Annals of neurology, 2019, Volume: 85, Issue:4

    Topics: Adult; Aged; Biomarkers; Cohort Studies; Disease Resistance; Female; Genetic Predisposition to Disea

2019
URAT1 mutations cause renal hypouricaemia combined with Fanconi syndrome in a Chinese patient.
    Nephrology (Carlton, Vic.), 2018, Volume: 23, Issue:8

    Topics: Asian People; DNA Mutational Analysis; Fanconi Syndrome; Genetic Predisposition to Disease; Humans;

2018
Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population.
    Journal of the American Society of Nephrology : JASN, 2019, Volume: 30, Issue:5

    Topics: Asian People; Calcium; Case-Control Studies; Female; Genetic Loci; Genetic Predisposition to Disease

2019
Functional Characterization of Clinically-Relevant Rare Variants in
    Cells, 2019, 04-18, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily G, Member 2;

2019
Association between SLC2A9 Genetic Variants and Risk of Hyperuricemia in a Uygur Population.
    Current medical science, 2019, Volume: 39, Issue:2

    Topics: Adult; Asian People; China; Cross-Sectional Studies; Female; Gene Frequency; Genetic Predisposition

2019
No association between MTHFR C677T and serum uric acid levels among Japanese with ABCG2 126QQ and SLC22A12 258WW.
    Nagoya journal of medical science, 2013, Volume: 75, Issue:1-2

    Topics: Adult; Age Factors; Aged; Asian People; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP

2013
Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study.
    American journal of epidemiology, 2013, May-01, Volume: 177, Issue:9

    Topics: Adult; Age Distribution; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Casset

2013
ALPK1 genetic regulation and risk in relation to gout.
    International journal of epidemiology, 2013, Volume: 42, Issue:2

    Topics: Adult; Alleles; Asian People; Case-Control Studies; Gene Expression Regulation; Genetic Predispositi

2013
Genetic variability related to serum uric acid concentration and risk of Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2013, Volume: 28, Issue:12

    Topics: Aged; Alleles; Disease Progression; Female; Genetic Predisposition to Disease; Genetic Variation; Ge

2013
Trp64Arg (rs4994) polymorphism of β3-adrenergic receptor gene is associated with hyperuricemia in a Chinese male population.
    Clinical chemistry and laboratory medicine, 2013, Volume: 51, Issue:9

    Topics: Adult; Aged; Asian People; Case-Control Studies; Genetic Predisposition to Disease; Genotype; Humans

2013
Effect of genetic polymorphisms on development of gout.
    The Journal of rheumatology, 2013, Volume: 40, Issue:8

    Topics: Adult; Asian People; Case-Control Studies; Gene Frequency; Genetic Predisposition to Disease; Genome

2013
Serum uric acid and blood pressure in children at cardiovascular risk.
    Pediatrics, 2013, Volume: 132, Issue:1

    Topics: Adolescent; Age Factors; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Child; Cohort Stu

2013
Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes.
    European psychiatry : the journal of the Association of European Psychiatrists, 2014, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Advanced Oxidation Protein Products; Bipolar Disorder; Brazil; Case-Control Studi

2014
Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility.
    Human cell, 2013, Volume: 26, Issue:4

    Topics: Aged; Female; Gene Expression; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Associ

2013
A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout.
    Drug metabolism and pharmacokinetics, 2014, Volume: 29, Issue:2

    Topics: Asian People; Case-Control Studies; Chi-Square Distribution; Gene Frequency; Genetic Association Stu

2014
Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function.
    Kidney international, 2014, Volume: 85, Issue:2

    Topics: Biomarkers; Confounding Factors, Epidemiologic; Creatinine; Enzyme Inhibitors; Female; Genetic Predi

2014
The association between gene polymorphisms of glutathione S-transferase T1/M1 and type 1 diabetes in Slovak children and adolescents.
    Central European journal of public health, 2013, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Child; Diabetes Mellitus, Type 1; Female; Genetic Predisposition to Disease; Glut

2013
Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility.
    Human cell, 2014, Volume: 27, Issue:1

    Topics: Actin Cytoskeleton; Actins; Carrier Proteins; Genetic Predisposition to Disease; Genetic Variation;

2014
Purine disorders with hypouricemia.
    Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki), 2014, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Child; Female; Genetic Predisposition to Disease; Humans; Male; Purine-Pyrimidine

2014
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.
    Scientific reports, 2014, Jun-09, Volume: 4

    Topics: Asian People; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transpor

2014
ABCG2 dysfunction increases the risk of renal overload hyperuricemia.
    Nucleosides, nucleotides & nucleic acids, 2014, Volume: 33, Issue:4-6

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Gene Fre

2014
NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:1

    Topics: Amino Acid Sequence; Animals; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition t

2015
Common variants related to serum uric acid concentrations are associated with glucose metabolism and insulin secretion in a Chinese population.
    PloS one, 2015, Volume: 10, Issue:1

    Topics: Adult; Aged; China; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Glucose; G

2015
Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Asian People; ATP Binding Cassette Transporter, S

2016
An unusual cause of pink diapers in an infant: Questions and Answers.
    Pediatric nephrology (Berlin, Germany), 2016, Volume: 31, Issue:4

    Topics: Biomarkers; Color; Crystallization; Diapers, Infant; DNA Mutational Analysis; Genetic Predisposition

2016
A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes.
    Diabetes, 2015, Volume: 64, Issue:8

    Topics: Adult; Diabetes Mellitus, Type 2; Female; Genetic Loci; Genetic Predisposition to Disease; Humans; M

2015
A coronary artery disease-associated SNP rs6903956 contributed to asymptomatic hyperuricemia susceptibility in Han Chinese.
    Lipids in health and disease, 2015, Apr-19, Volume: 14

    Topics: Asian People; Asymptomatic Diseases; Case-Control Studies; China; Coronary Artery Disease; Female; G

2015
Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Aged; Alleles; Asian People; Body Mass Index; Catechol O-Methyltransferase; China; Female; Gene Freq

2015
Causal or Noncausal Relationship of Uric Acid With Diabetes.
    Diabetes, 2015, Volume: 64, Issue:8

    Topics: Diabetes Mellitus, Type 2; Female; Genetic Loci; Genetic Predisposition to Disease; Humans; Male; Ur

2015
Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index.
    Rheumatology international, 2016, Volume: 36, Issue:2

    Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Body Mass Index; Comorbidity; Female; Gene Frequen

2016
WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients.
    Rheumatology international, 2016, Volume: 36, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Asian People; Biomarkers; Blood Gluco

2016
Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population.
    The Korean journal of internal medicine, 2015, Volume: 30, Issue:6

    Topics: Arthritis, Gouty; Asian People; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding

2015
Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1.
    BMJ open, 2015, Nov-24, Volume: 5, Issue:11

    Topics: Adult; Alleles; Asian People; Case-Control Studies; Genetic Predisposition to Disease; Genotype; Hum

2015
rs3806268 of NLRP3 gene polymorphism is associated with the development of primary gout.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:10

    Topics: Adult; Alleles; Asian People; Biomarkers; Female; Gene Frequency; Genetic Predisposition to Disease;

2015
Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2017, Volume: 116, Issue:1

    Topics: Adult; Alleles; ATP Binding Cassette Transporter, Subfamily G, Member 2; Female; Genetic Predisposit

2017
PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients.
    Genetics and molecular research : GMR, 2016, Feb-11, Volume: 15, Issue:1

    Topics: Asian People; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transpor

2016
Association between serum uric acid related genetic loci and diabetic kidney disease in the Chinese type 2 diabetes patients.
    Journal of diabetes and its complications, 2016, Volume: 30, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Alleles; ATP Binding Cassette Transporter, Subfamily G, Member

2016
Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia.
    Scientific reports, 2016, 06-08, Volume: 6

    Topics: Amino Acid Substitution; Asian People; Female; Genetic Predisposition to Disease; Haplotypes; Humans

2016
Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans.
    Clinical and experimental nephrology, 2017, Volume: 21, Issue:3

    Topics: Adult; Asian People; Biomarkers; Blood Glucose; Chi-Square Distribution; Female; Gene-Environment In

2017
Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout.
    International journal of rheumatic diseases, 2018, Volume: 21, Issue:3

    Topics: Adult; Aged; Case-Control Studies; Chi-Square Distribution; Creatinine; Gene Frequency; Genetic Asso

2018
Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Animals; Collagen Type IV; Dog Diseases; Dogs; Dwarfism; Factor VII; Genetic Counseling; Genetic Pre

2016
Associations of VCAM-1 gene polymorphisms with obesity and inflammation markers.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017, Volume: 66, Issue:3

    Topics: Adult; Asian People; C-Reactive Protein; Female; Gene Frequency; Genetic Predisposition to Disease;

2017
The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 41, Issue:1

    Topics: Aged; Alleles; Arteriosclerosis Obliterans; Asian People; Blood Glucose; Body Mass Index; CARD Signa

2017
Effects of multiple genetic loci on the pathogenesis from serum urate to gout.
    Scientific reports, 2017, 03-02, Volume: 7

    Topics: Alleles; Case-Control Studies; Disease Progression; Female; Gene Expression; Genetic Association Stu

2017
Differing urinary urea excretion among children with idiopathic hypercalciuria and/or hyperuricosuria.
    Journal of pediatric urology, 2008, Volume: 4, Issue:1

    Topics: Child; Child, Preschool; Cross-Sectional Studies; Dietary Proteins; Female; Genetic Predisposition t

2008
Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:9

    Topics: Adult; Chromosomes, Human, Pair 4; Female; Gene Frequency; Genetic Predisposition to Disease; Geneti

2008
Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:2

    Topics: Adult; Cardiovascular Diseases; Chromosomes, Human, Pair 3; Female; Genetic Predisposition to Diseas

2009
Prevalence of hypouricaemia and SLC22A12 mutations in healthy Korean subjects.
    Nephrology (Carlton, Vic.), 2008, Volume: 13, Issue:8

    Topics: Adult; Asian People; Blood Pressure; Creatinine; Female; Gene Frequency; Genetic Predisposition to D

2008
NALP3 inflammasome functional polymorphisms and gout susceptibility.
    Cell cycle (Georgetown, Tex.), 2009, Jan-01, Volume: 8, Issue:1

    Topics: Carrier Proteins; Genetic Predisposition to Disease; Gout; Humans; Inflammation; Interleukin-1beta;

2009
Association between two common polymorphisms of PPARgamma gene and metabolic syndrome families in a Chinese population.
    Archives of medical research, 2009, Volume: 40, Issue:2

    Topics: Adult; Aged; Alleles; China; Cholesterol, HDL; Creatinine; Female; Gene Frequency; Genetic Predispos

2009
Genome-wide linkage analysis for uric acid in families enriched for hypertension.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:8

    Topics: Chromosome Mapping; Chromosomes, Human, Pair 8; Cohort Studies; Creatinine; Female; Genetic Linkage;

2009
High-resolution melting analysis for the rapid detection of an intronic single nucleotide polymorphism in SLC22A12 in male patients with primary gout in China.
    Scandinavian journal of rheumatology, 2009, Volume: 38, Issue:4

    Topics: Adult; Aged; Analysis of Variance; Case-Control Studies; China; DNA Mutational Analysis; Genetic Pre

2009
KLOTHO gene polymorphisms G-395A and C1818T are associated with low-density lipoprotein cholesterol and uric acid in Japanese hemodialysis patients.
    American journal of nephrology, 2009, Volume: 30, Issue:4

    Topics: Aged; Asian People; Cholesterol, LDL; Female; Gene Frequency; Genetic Predisposition to Disease; Gen

2009
Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.
    PloS one, 2009, Nov-05, Volume: 4, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding

2009
Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines.
    Human genetics, 2010, Volume: 127, Issue:2

    Topics: Adult; Aged; Alleles; Asian People; Female; Gene Frequency; Genetic Predisposition to Disease; Genot

2010
Trp64Arg polymorphism of the ADRB3 gene predicts hyperuricemia risk in a population from southern Spain.
    The Journal of rheumatology, 2010, Volume: 37, Issue:2

    Topics: Adolescent; Adult; Aged; Alleles; Chi-Square Distribution; Cohort Studies; Female; Genetic Predispos

2010
Clinical manifestations and etiology of renal stones in children less than 14 years age.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2010, Volume: 21, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Citric Acid; Cystinuria; Dysuria; Female; Fever; Genetic Predis

2010
Evaluation of trends in urolith composition and characteristics of dogs with urolithiasis: 25,499 cases (1985-2006).
    Journal of the American Veterinary Medical Association, 2010, Jan-15, Volume: 236, Issue:2

    Topics: Animals; Apatites; Calcium Oxalate; Calculi; Cystine; Dog Diseases; Dogs; Female; Genetic Predisposi

2010
Xanthine dehydrogenase deficiency with novel sequence variations presenting as rheumatoid arthritis in a 78-year-old patient.
    Journal of inherited metabolic disease, 2010, Volume: 33 Suppl 3

    Topics: Aged; Allopurinol; Arthritis, Rheumatoid; Biomarkers; Chromatography, High Pressure Liquid; DNA Muta

2010
[Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population].
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2010, Volume: 27, Issue:1

    Topics: Adult; Aged; Asian People; Blood Pressure; Case-Control Studies; China; Female; Genetic Predispositi

2010
The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people.
    Rheumatology (Oxford, England), 2010, Volume: 49, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Asian People; ATP Binding Cassette Transporter, Subfamily G, Member

2010
Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins.
    Gastroenterology, 2010, Volume: 139, Issue:3

    Topics: Adult; Biomarkers; Blood Pressure; California; Cross-Sectional Studies; Dyslipidemias; Fatty Liver;

2010
Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers.
    American journal of veterinary research, 2010, Volume: 71, Issue:8

    Topics: Animals; Creatinine; DNA; Dog Diseases; Dogs; Gene Frequency; Genetic Carrier Screening; Genetic Pre

2010
Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.
    The Journal of biological chemistry, 2010, Nov-05, Volume: 285, Issue:45

    Topics: Animals; Bumetanide; Diuretics; Furosemide; Genetic Predisposition to Disease; Glucose Transport Pro

2010
Genome-wide study of familial juvenile hyperuricaemic (gouty) nephropathy (FJHN) indicates a new locus, FJHN3, linked to chromosome 2p22.1-p21.
    Human genetics, 2011, Volume: 129, Issue:1

    Topics: Chromosomes, Human, Pair 2; Female; Genetic Heterogeneity; Genetic Linkage; Genetic Loci; Genetic Pr

2011
Mechanisms for phenotypic variation in Lesch-Nyhan disease and its variants.
    Human genetics, 2011, Volume: 129, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Genetic Predisposition to Disease; Humans; Hypoxanthine

2011
Orange-colored diapers in infants from families with gout.
    Pediatric nephrology (Berlin, Germany), 2011, Volume: 26, Issue:6

    Topics: Color; Diagnostic Errors; Diapers, Infant; Family Health; Genetic Predisposition to Disease; Gout; H

2011
Application of a new method for GWAS in a related case/control sample with known pedigree structure: identification of new loci for nephrolithiasis.
    PLoS genetics, 2011, Jan-20, Volume: 7, Issue:1

    Topics: Carrier Proteins; Case-Control Studies; Cohort Studies; Data Interpretation, Statistical; Genetic Lo

2011
G109T polymorphism of SLC22A12 gene is associated with serum uric acid level, but not with metabolic syndrome.
    Rheumatology international, 2012, Volume: 32, Issue:8

    Topics: Adult; Asian People; Biomarkers; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cros

2012
Lymphocyte α-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses.
    Journal of molecular medicine (Berlin, Germany), 2011, Volume: 89, Issue:12

    Topics: Cell Line, Tumor; Enzyme Induction; Gene Expression Profiling; Genetic Predisposition to Disease; Go

2011
Phenotype and outcome in hereditary tubulointerstitial nephritis secondary to UMOD mutations.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:10

    Topics: Adult; Belgium; Biomarkers; Central Nervous System Diseases; Chi-Square Distribution; Dental Enamel;

2011
ABCG2/BCRP dysfunction as a major cause of gout.
    Nucleosides, nucleotides & nucleic acids, 2011, Volume: 30, Issue:12

    Topics: Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette T

2011
Effects of SLC2A9 variants on uric acid levels in a Korean population.
    Rheumatology international, 2013, Volume: 33, Issue:1

    Topics: Adult; Chromosomes, Human, Pair 4; Cohort Studies; Female; Genetic Predisposition to Disease; Genome

2013
Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.
    Annals of human genetics, 2012, Volume: 76, Issue:2

    Topics: Croatia; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Pol

2012
Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I.
    American journal of medical genetics. Part A, 2012, Volume: 158A, Issue:2

    Topics: Ataxia; Child, Preschool; Deaf-Blind Disorders; Enzyme Activation; Genetic Diseases, X-Linked; Genet

2012
Validation of 7 type 2 diabetes mellitus risk scores in a population-based cohort: CoLaus study.
    Archives of internal medicine, 2012, Jan-23, Volume: 172, Issue:2

    Topics: Age Distribution; Blood Glucose; Body Mass Index; Cholesterol, HDL; Cohort Studies; Diabetes Mellitu

2012
Association between gout and polymorphisms in GCKR in male Han Chinese.
    Human genetics, 2012, Volume: 131, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Asian People; Blood Glucose; Case-Control Studies; China; Chol

2012
Genetic architecture for susceptibility to gout in the KARE cohort study.
    Journal of human genetics, 2012, Volume: 57, Issue:6

    Topics: Binding Sites; Cohort Studies; Genetic Loci; Genetic Predisposition to Disease; Gout; Humans; Polymo

2012
Is the apolipoprotein E4 allele always hazardous? Serum uric acid level as a conflict.
    Genetic testing and molecular biomarkers, 2012, Volume: 16, Issue:8

    Topics: Adult; Alleles; Apolipoprotein E4; Cardiovascular Diseases; Genetic Predisposition to Disease; Human

2012
Serum uric acid levels are associated with polymorphism in the SAA1 gene in Chinese subjects.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Asian People; China; Confounding Factors, Epidemiologic; Demography; Ethnicity; Female; Genetic Pred

2012
Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambuì Cohort Study of Ageing (1997-2008).
    Hypertension research : official journal of the Japanese Society of Hypertension, 2013, Volume: 36, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Alleles; Apolipoproteins E; Blood Pressure; Brazil; Cohort Studies;

2013
Absence of the SLC22A12 gene mutation in Turkish population with primary gout disease.
    Rheumatology international, 2013, Volume: 33, Issue:11

    Topics: Adult; Female; Genetic Predisposition to Disease; Gout; Humans; Hyperuricemia; Male; Middle Aged; Mu

2013
Genetic impact on uric acid concentration and hyperuricemia in the Japanese population.
    Journal of atherosclerosis and thrombosis, 2013, Volume: 20, Issue:4

    Topics: Aged; Asian People; Coronary Disease; Diabetes Mellitus, Type 2; Female; Genetic Loci; Genetic Predi

2013
Urinary stone disease in the first year of life: is it dangerous?
    Pediatric surgery international, 2013, Volume: 29, Issue:3

    Topics: Cholelithiasis; Citrates; Cystic Fibrosis; Cystinuria; Epilepsy; Female; Genetic Predisposition to D

2013
Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Black or African American; Demography; Female; Fructokinases; Genetic Predisposition to Disease; Glu

2013
Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate.
    American journal of human genetics, 2003, Volume: 72, Issue:6

    Topics: Amino Acid Sequence; Chromosomes, Human, Y; Consensus Sequence; DNA-Binding Proteins; DNA, Mitochond

2003
Urinary glycosaminoglycans as risk factors for uric acid nephrolithiasis: case control study in a Sardinian genetic isolate.
    Urology, 2003, Volume: 62, Issue:3

    Topics: Case-Control Studies; Female; Genetic Predisposition to Disease; Glycosaminoglycans; Humans; Italy;

2003
Combination of renin-angiotensin system polymorphisms is associated with altered renal sodium handling and hypertension.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:3

    Topics: Adult; Aged; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Kidn

2004
Family-based associations between the angiotensin- converting enzyme insertion/deletion polymorphism and multiple cardiovascular risk factors in Chinese.
    Journal of hypertension, 2004, Volume: 22, Issue:3

    Topics: Adult; Aged; Asian People; Blood Glucose; Blood Pressure; Body Mass Index; Creatinine; Family Health

2004
The C677 mutation in methylene tetrahydrofolate reductase gene: correlation with uric acid and cardiovascular risk factors in elderly Korean men.
    Journal of Korean medical science, 2004, Volume: 19, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Genetic Predisposition to Disease; Genotype

2004
Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA03.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2006, Volume: 17, Issue:4

    Topics: Animals; Chromosome Mapping; Crosses, Genetic; Dog Diseases; Dogs; Female; Genetic Linkage; Genetic

2006
G-protein beta3 subunit gene variant is unlikely to have a significant influence on serum uric acid level in Japanese workers.
    The Tohoku journal of experimental medicine, 2006, Volume: 209, Issue:2

    Topics: Cross-Sectional Studies; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Het

2006
High urinary calcium excretion and genetic susceptibility to hypertension and kidney stone disease.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:9

    Topics: Adolescent; Adult; Calcium; Creatinine; Family Health; Female; Genetic Predisposition to Disease; Hu

2006
Association of methylenetetrahydrofolate reductase (C677T) polymorphism with hyperuricemia.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2007, Volume: 17, Issue:6

    Topics: Adult; Aged; Female; Gene Frequency; Genetic Predisposition to Disease; Heterozygote; Homozygote; Hu

2007
[European League Against Rheumatism evidence-based recommendations for diagnosis and management of gout].
    Zeitschrift fur Rheumatologie, 2007, Volume: 66, Issue:7

    Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Delphi Technique

2007
Absence of SLC22A12 gene mutations in Greek Caucasian patients with primary renal hypouricaemia.
    Scandinavian journal of clinical and laboratory investigation, 2007, Volume: 67, Issue:6

    Topics: Adult; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genotype; Greece; Humans;

2007
Metabolic risk factors in children with kidney stone disease.
    Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:7

    Topics: Abdominal Pain; Adolescent; Argentina; Child; Child, Preschool; Citrates; Female; Genetic Predisposi

2008
Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.
    PloS one, 2008, Apr-09, Volume: 3, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Coronary Artery Disease; Female; Genetic Predi

2008
Acceleration of hypertensive cerebral injury by the inhibition of xanthine-xanthine oxidase system in stroke-prone spontaneously hypertensive rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1997, Volume: 19, Issue:4

    Topics: Allopurinol; Amitrole; Animals; Brain; Catalase; Cerebral Cortex; Cerebrovascular Disorders; Enzyme

1997
Maternal effect of Type 2 diabetes mellitus on insulin sensitivity and metabolic profile in healthy young Mexicans.
    Diabetes, nutrition & metabolism, 1999, Volume: 12, Issue:1

    Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Creatinin

1999
Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety).
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:5

    Topics: Adult; Analysis of Variance; Arteriosclerosis; Blood Glucose; Cholesterol; Cholesterol, HDL; Diabete

2000
Identification of a new candidate locus for uric acid nephrolithiasis.
    American journal of human genetics, 2001, Volume: 68, Issue:5

    Topics: Alleles; Anthropometry; Chromosome Mapping; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 20

2001
Lp(a), homocysteine and a family history of early ischemic cerebral stroke.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2001, Volume: 11 Suppl 5

    Topics: Adolescent; Adult; Brain Ischemia; Factor VII; Female; Fibrinogen; Genetic Predisposition to Disease

2001