Page last updated: 2024-10-20

uric acid and Fatty Liver

uric acid has been researched along with Fatty Liver in 107 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

Research Excerpts

ExcerptRelevanceReference
" For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome."8.98Uric Acid as a Cause of the Metabolic Syndrome. ( Jensen, T; Johnson, RJ; King, C; Lanaspa, MA; Sánchez-Lozada, LG; Tolan, DR, 2018)
"Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome."7.83Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. ( He, H; Li, D; Li, Y; Lin, Y; Liu, X; Lu, C; Sang, J; Wan, X; Xu, C; Yu, C, 2016)
" After adjusting for demographics, hypertension, waist circumference, triglycerides, high-density lipoprotein-cholesterol, homeostasis model assessment-estimated insulin resistance, estimated glomerular filtration rate, and aspartate aminotransferase, uric acid (4th quartile) was significantly associated with NAFLD (odds ratio 1."7.79Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. ( Chonchol, M; Jalal, DI; Johnson, RJ; McFann, K; Sirota, JC; Targher, G, 2013)
"Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance."7.79Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. ( Gao, Y; Hu, Y; Huang, Z; Li, L; Li, Z; Liang, Z; Liao, M; Lu, Z; Mo, Z; Peng, T; Qin, X; Shi, D; Sun, Y; Tan, A; Wang, M; Wu, C; Xie, Y; Yang, X; Zhang, H; Zhang, S; Zhang, Y, 2013)
"The aim of this study was to compare serum uric acid values in two ethnically distinct Chinese populations: Uyghur, with a high prevalence of nonalcoholic fatty liver disease, and Han, with a lower prevalence."7.79Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China. ( Cai, W; Miao, L; Sun, YP; Wu, X; Yao, H; Zhang, B; Zou, Y, 2013)
"Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown."7.78Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. ( Choi, YJ; Cicerchi, C; Duranay, M; Ishimoto, T; Johnson, RJ; Kanbay, M; Kang, DH; Lanaspa, MA; Li, N; Marek, G; Nakagawa, T; Rodriguez-Iturbe, B; Roncal-Jimenez, CA; Sanchez-Lozada, LG; Sautin, YY; Schreiner, G, 2012)
"The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men."7.77Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. ( Chang, Y; Cho, J; Guallar, E; Kim, SG; Ryu, S, 2011)
"The objective of the present study was to determine the relationship between serum uric acid (SUA) level and the presence of nonalcoholic fatty liver disease (NAFLD)."7.77The relationship between normal serum uric acid and nonalcoholic fatty liver disease. ( Ahn, HY; Hwang, IC; Suh, AR; Suh, SY, 2011)
"Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease, and serum uric acid is observed to be significantly elevated in NAFLD patients."7.76High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study. ( Li, Y; Miao, M; Xu, C; Xu, L; Yu, C, 2010)
"Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance."7.76Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. ( Lee, HR; Lee, JH; Lee, YJ; Shim, JY; Shin, YH, 2010)
"Serum uric acid level has been suggested to be associated with factors that contribute to the metabolic syndrome."7.75Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study. ( Li, Y; Miao, M; Xu, C; Xu, L; Yu, C, 2009)
"Fasting insulin and serum uric acid levels indicating insulin resistance, but not indices of iron overload, are independent predictors of non-alcoholic fatty liver disease."7.71Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study. ( Bagni, A; Bertolotti, M; Borsatti, A; Carulli, N; Ganazzi, D; Leonardi, F; Lonardo, A; Loria, P; Neri, P; Pulvirenti, M; Verrone, AM, 2002)
"We investigated the relationship between the concentration of circulating leptin and fatty liver by measuring the serum concentration of leptin in 284 male students who received the matriculation health examination in Okayama University in 1996 (n = 197; age, 18-20 yr) or 1997 (n = 87; age, 18-20 yr)."7.70Relationship between serum leptin and fatty liver in Japanese male adolescent university students. ( Higashi, T; Imai, A; Iwasaki, Y; Matsuura, K; Ogura, T; Shimomura, H; Tobe, K; Tsuji, T; Tsukamoto, C, 1999)
"Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O2(-)), in humans."6.45Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders? ( Nozaki, S; Onuma, M; Suzuki, I; Yamauchi, T, 2009)
"Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis."5.51Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD). ( Aller, R; Ampuero, J; Andrade, RJ; Aspichueta, P; Buque, X; Burgos-Santamaría, D; Fernández Rodríguez, CM; Gómez-Camarero, J; Gutiérrez García, ML; Hernández-Guerra, M; Latorre, M; Martín-Mateos, RMª; Romero-Gómez, M; Rosales, JM, 2019)
"Nonalcoholic fatty liver disease (NAFLD) is an emerging health problem worldwide."5.39Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women. ( Moon, SS, 2013)
"Addition of fructose to the diet of normal weight and overweight subjects can increase postprandial plasma triglyceride and uric acid concentration."5.24Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial. ( Boesch, C; Brandejsky, V; Campos, V; Despland, C; Kreis, R; Schneiter, P; Tappy, L, 2017)
" vulgaris extract to the therapeutic regimen of NAFLD including metformin and vitamin E, is associated with favorable effects on serum levels of transaminases, triglycerides as well as insulin sensitivity."5.16Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial. ( Beiraghdar, F; Ghamarchehreh, ME; Jalalian, HR; Panahi, Y; Sahebkar, A; Zare, R, 2012)
" For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome."4.98Uric Acid as a Cause of the Metabolic Syndrome. ( Jensen, T; Johnson, RJ; King, C; Lanaspa, MA; Sánchez-Lozada, LG; Tolan, DR, 2018)
"Both elevated levels of uric acid and non-alcoholic fatty liver disease (NAFLD) have been associated with increased vascular risk."4.87Hyperuricaemia and non-alcoholic fatty liver disease (NAFLD): a relationship with implications for vascular risk? ( Athyros, VG; Karagiannis, A; Katsiki, N; Mikhailidis, DP, 2011)
" Laboratory tests revealed liver dysfunction, coagulopathy, hypoglycemia, hypoproteinemia, leukocytosis, and elevated creatinine and uric acid levels."4.12Timely identification and successful treatment of acute fatty liver of pregnancy without obvious clinical symptoms: Case reports. ( Cao, W; Chen, T; Geng, Y; Jiang, W; Wang, Q; Wang, X; Xie, B, 2022)
"001), fibroblast growth factor 21, homeostasis model assessment of insulin resistance as an insulin resistance index and uric acid, and was negatively correlated with levels of high-density lipoprotein cholesterol and adiponectin."4.12Circulating level of fatty acid-binding protein 4 is an independent predictor of metabolic dysfunction-associated fatty liver disease in middle-aged and elderly individuals. ( Furuhashi, M; Higashiura, Y; Koyama, M; Ohnishi, H; Saitoh, S; Sakai, A; Shimamoto, K; Takahashi, S; Tanaka, M, 2022)
"High serum uric acid levels increase the risk of liver steatosis in lean patients."3.96Hepatic Steatosis in Lean Patients: Risk Factors and Impact on Mortality. ( Eigenbauer, E; Forstner, B; Mandorfer, M; Muckenhuber, M; Paternostro, R; Pfisterer, N; Reiberger, T; Scheiner, B; Scheuba, K; Trauner, M; Unger, LW, 2020)
"High-dose exenatide treatment can effectively reduce body mass of obese mice, but it has little difference when compared with dietary intervention in improving blood fat and liver steatosis."3.85[The Preliminary Investigation of GLP-1 Receptor Agonist on Liver Steatosis in Obese Mice]. ( An, ZM; He, H; Huang, HJ; Li, SQ; Li, SY; Liang, LB; Wang, X; Zhang, M, 2017)
"Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome."3.83Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. ( He, H; Li, D; Li, Y; Lin, Y; Liu, X; Lu, C; Sang, J; Wan, X; Xu, C; Yu, C, 2016)
" Variables included were waist circumference (WC), glucose, high-density lipoprotein (HDL), triglycerides (TGL), blood pressure, insulin resistance (by homeostatic model assessment HOMA-index), acanthosis nigricans (AN), uric acid, serum glutamic oxaloacetic transaminase (GOT) and alanine transaminase, and hepatic sonogram."3.83Models Predictive of Metabolic Syndrome Components in Obese Pediatric Patients. ( Barrera-de Leon, JC; Colunga Rodríguez, C; Hurtado López, EF; López Beltrán, AL; Ortega-Cortes, R; Tlacuilo-Parra, A; Trujillo, X, 2016)
"Serum uric acid levels are significantly associated with nonalcoholic fatty liver disease (NAFLD)."3.80The significance of serum xanthine oxidoreductase in patients with nonalcoholic fatty liver disease. ( Chen, Y; Xu, C; Zhang, J; Zhao, Y, 2014)
"Serum uric acid levels have been reported to be associated with non-alcoholic fatty liver disease (NAFLD)."3.80Relationship between serum uric acid levels and hepatic steatosis in non-obese postmenopausal women. ( Chen, Y; Liu, PJ; Lou, HP; Ma, F; Zhu, YN, 2014)
"Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance."3.79Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. ( Gao, Y; Hu, Y; Huang, Z; Li, L; Li, Z; Liang, Z; Liao, M; Lu, Z; Mo, Z; Peng, T; Qin, X; Shi, D; Sun, Y; Tan, A; Wang, M; Wu, C; Xie, Y; Yang, X; Zhang, H; Zhang, S; Zhang, Y, 2013)
"The aim of this study was to compare serum uric acid values in two ethnically distinct Chinese populations: Uyghur, with a high prevalence of nonalcoholic fatty liver disease, and Han, with a lower prevalence."3.79Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China. ( Cai, W; Miao, L; Sun, YP; Wu, X; Yao, H; Zhang, B; Zou, Y, 2013)
" After adjusting for demographics, hypertension, waist circumference, triglycerides, high-density lipoprotein-cholesterol, homeostasis model assessment-estimated insulin resistance, estimated glomerular filtration rate, and aspartate aminotransferase, uric acid (4th quartile) was significantly associated with NAFLD (odds ratio 1."3.79Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. ( Chonchol, M; Jalal, DI; Johnson, RJ; McFann, K; Sirota, JC; Targher, G, 2013)
"Several works observed a link between uric acid serum levels and clinical and histological features of nonalcoholic fatty liver disease."3.78Hyperuricaemia: another metabolic feature affecting the severity of chronic hepatitis because of HCV infection. ( Cabibi, D; Cammà, C; Craxì, A; Macaluso, FS; Marco, VD; Petta, S, 2012)
"Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown."3.78Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. ( Choi, YJ; Cicerchi, C; Duranay, M; Ishimoto, T; Johnson, RJ; Kanbay, M; Kang, DH; Lanaspa, MA; Li, N; Marek, G; Nakagawa, T; Rodriguez-Iturbe, B; Roncal-Jimenez, CA; Sanchez-Lozada, LG; Sautin, YY; Schreiner, G, 2012)
" In this line recent studies observed an independent link between higher uric acid serum levels and clinical diagnosis of non-alcoholic fatty liver disease (NAFLD)."3.77Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease. ( Cabibi, D; Cammà, C; Craxì, A; Di Marco, V; Petta, S, 2011)
"The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men."3.77Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. ( Chang, Y; Cho, J; Guallar, E; Kim, SG; Ryu, S, 2011)
"The objective of the present study was to determine the relationship between serum uric acid (SUA) level and the presence of nonalcoholic fatty liver disease (NAFLD)."3.77The relationship between normal serum uric acid and nonalcoholic fatty liver disease. ( Ahn, HY; Hwang, IC; Suh, AR; Suh, SY, 2011)
"Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance."3.76Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. ( Lee, HR; Lee, JH; Lee, YJ; Shim, JY; Shin, YH, 2010)
"Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease, and serum uric acid is observed to be significantly elevated in NAFLD patients."3.76High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study. ( Li, Y; Miao, M; Xu, C; Xu, L; Yu, C, 2010)
"Diets containing 30% of fructose either as free fructose and glucose, or as sucrose, induce metabolic syndrome, intrahepatic accumulation of uric acid and TGs, increased MCP-1 and TNF-alpha as well as fatty liver in rats."3.76Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. ( Abdelmalek, M; Johnson, RJ; Lan, HY; Le, M; Mu, W; Nakagawa, T; Reungjui, S; Roncal, C; Sánchez-Lozada, LG; Sautin, YY; Yu, X, 2010)
"Serum uric acid level has been suggested to be associated with factors that contribute to the metabolic syndrome."3.75Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study. ( Li, Y; Miao, M; Xu, C; Xu, L; Yu, C, 2009)
"Fasting insulin and serum uric acid levels indicating insulin resistance, but not indices of iron overload, are independent predictors of non-alcoholic fatty liver disease."3.71Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study. ( Bagni, A; Bertolotti, M; Borsatti, A; Carulli, N; Ganazzi, D; Leonardi, F; Lonardo, A; Loria, P; Neri, P; Pulvirenti, M; Verrone, AM, 2002)
"We investigated the relationship between the concentration of circulating leptin and fatty liver by measuring the serum concentration of leptin in 284 male students who received the matriculation health examination in Okayama University in 1996 (n = 197; age, 18-20 yr) or 1997 (n = 87; age, 18-20 yr)."3.70Relationship between serum leptin and fatty liver in Japanese male adolescent university students. ( Higashi, T; Imai, A; Iwasaki, Y; Matsuura, K; Ogura, T; Shimomura, H; Tobe, K; Tsuji, T; Tsukamoto, C, 1999)
"Although the systemic physiological alterations present in pre-eclampsia appear disparate and unrelated, four of them (endothelial cell hyperplasia and alterations in uric acid, calcium, and prostaglandin homeostasis) are demonstrated here to mimic closely the pattern of intracellular alterations caused by the activation of a G protein-associated receptor."3.69Pre-eclampsia: excessive activation of a G protein-associated receptor? ( Coffey, CG, 1995)
"Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O2(-)), in humans."2.45Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders? ( Nozaki, S; Onuma, M; Suzuki, I; Yamauchi, T, 2009)
"Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis."1.51Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD). ( Aller, R; Ampuero, J; Andrade, RJ; Aspichueta, P; Buque, X; Burgos-Santamaría, D; Fernández Rodríguez, CM; Gómez-Camarero, J; Gutiérrez García, ML; Hernández-Guerra, M; Latorre, M; Martín-Mateos, RMª; Romero-Gómez, M; Rosales, JM, 2019)
"Uric acid nephrolithiasis is associated with an elevated visceral fat area in kidney stone formers."1.46Computerized Tomography Based Diagnosis of Visceral Obesity and Hepatic Steatosis is Associated with Low Urine pH. ( Calle, J; Monga, M; Patel, ND; Remer, EM; Ward, RD, 2017)
"In conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed."1.40Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. ( Behling, C; Donithan, M; Hallinan, EK; Newton, KP; Schwimmer, JB; Tonascia, J; Xanthakos, SA; Zepeda, A, 2014)
"Nonalcoholic fatty liver disease (NAFLD) is an emerging health problem worldwide."1.39Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women. ( Moon, SS, 2013)
"Children with NAFLD have a diet that is insufficient in vitamin E and this may contribute to the pathophysiology of NAFLD."1.38Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD. ( Belt, P; Colvin, R; Lavine, JE; Molleston, JP; Murray, KF; Rosenthal, P; Schwimmer, JB; Tonascia, J; Unalp, A; Vos, MB, 2012)
"Patients with NAFLD had significantly lower levels of serum-free thyroxine (FT4) than controls (11·12 ± 1·43 vs 11·58 ± 1·47 pmol/l; P < 0·001)."1.37Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese. ( Li, Y; Miao, M; Xu, C; Xu, L; Yu, C, 2011)
" In addition, there was a dose-response relationship between SU and NAFLD in subjects with and without gout."1.36Gout and risk of non-alcoholic fatty liver disease. ( Chang, HC; Chen, HW; Chiu, CT; Hwang, JS; Ko, YS; Kuo, CF; Luo, SF; See, LC; Tseng, WY; Yu, KH, 2010)
"Insulin resistance was determined by using homeostasis model assessment (HOMA-IR)."1.34Ultrasonographic and biochemical evaluation of visceral obesity in obese women with non-alcoholic fatty liver disease. ( Akdag, B; Fenkci, S; Rota, S; Sabir, N, 2007)
"Insulin resistance is a risk factors for non-alcoholic fatty liver disease (NAFLD) and for gallstone disease (GD)."1.33Gallstone disease in non-alcoholic fatty liver: prevalence and associated factors. ( Bertolotti, M; Carulli, L; Carulli, N; D'Amico, R; Ganazzi, D; Lombardini, S; Lonardo, A; Loria, P; Rudilosso, A; Verrone, A, 2005)
"Furthermore, obesity is a well characterized insulin resistant condition that is often associated with hepatic steatosis."1.32Insulin sensitivity and hepatic steatosis in obese subjects with normal glucose tolerance. ( Muggeo, M; Venturi, C; Zamboni, C; Zoppini, G, 2004)

Research

Studies (107)

TimeframeStudies, this research(%)All Research%
pre-199029 (27.10)18.7374
1990's3 (2.80)18.2507
2000's10 (9.35)29.6817
2010's53 (49.53)24.3611
2020's12 (11.21)2.80

Authors

AuthorsStudies
Tanaka, M1
Takahashi, S1
Higashiura, Y1
Sakai, A1
Koyama, M1
Saitoh, S1
Shimamoto, K1
Ohnishi, H1
Furuhashi, M1
Cao, W1
Chen, T1
Jiang, W1
Geng, Y1
Xie, B1
Wang, Q1
Wang, X3
Qu, J1
Dou, J1
Wang, A1
Liu, Y1
Lin, L1
Chen, K1
Zang, L1
Mu, Y1
Duan, H1
Zhang, R1
Chen, X1
Yu, G1
Song, C1
Jiang, Y1
He, Y1
Wan, H1
Shen, J1
Zeng, H1
Tang, C1
Lin, B1
Yu, M1
Wang, J1
Chen, S1
Yu, C5
Wang, H1
Ba, Y1
Gao, X2
Zhuo, J1
Li, Y5
Sun, J1
Zhang, S2
Unger, LW1
Forstner, B1
Muckenhuber, M1
Scheuba, K1
Eigenbauer, E1
Scheiner, B1
Pfisterer, N1
Paternostro, R1
Trauner, M1
Mandorfer, M1
Reiberger, T1
Nishikawa, T1
Nagata, N1
Shimakami, T1
Shirakura, T1
Matsui, C1
Ni, Y1
Zhuge, F1
Xu, L5
Chen, G1
Nagashimada, M1
Yamashita, T2
Sakai, Y1
Mizukoshi, E1
Honda, M1
Kaneko, S1
Ota, T1
Li, H1
Guo, M1
An, Z1
Meng, J1
Jiang, J1
Song, J1
Wu, W1
Matsushita, Y1
Hasegawa, Y1
Takebe, N1
Onodera, K1
Shozushima, M1
Oda, T1
Nagasawa, K1
Honma, H1
Nata, K1
Sasaki, A1
Ishigaki, Y1
Mazzoli, A1
Gatto, C1
Crescenzo, R1
Cigliano, L1
Iossa, S1
Zhang, J2
Xu, J1
Lin, X1
Tang, F1
Tan, L1
Patel, ND1
Ward, RD1
Calle, J1
Remer, EM1
Monga, M1
He, H2
Liang, LB1
Zhang, M1
Li, SY1
Li, SQ1
An, ZM1
Huang, HJ1
King, C1
Lanaspa, MA7
Jensen, T2
Tolan, DR1
Sánchez-Lozada, LG8
Johnson, RJ11
Cicero, AFG1
Gitto, S1
Fogacci, F1
Rosticci, M1
Giovannini, M1
D'Addato, S1
Andreone, P1
Borghi, C1
Niwa, K1
Hisatome, I1
Kanbay, M2
Andres-Hernando, A3
Roncal-Jimenez, CA5
Sato, Y1
Garcia, G2
Ohno, M1
Kuwabara, M1
Fernández Rodríguez, CM1
Aller, R1
Gutiérrez García, ML1
Ampuero, J1
Gómez-Camarero, J1
Martín-Mateos, RMª1
Burgos-Santamaría, D1
Rosales, JM1
Aspichueta, P1
Buque, X1
Latorre, M1
Andrade, RJ1
Hernández-Guerra, M1
Romero-Gómez, M1
Moon, SS1
Bray, GA1
Neuschwander-Tetri, BA1
Xie, Y1
Wang, M1
Zhang, Y1
Tan, A1
Gao, Y1
Liang, Z1
Shi, D1
Huang, Z1
Zhang, H1
Yang, X2
Lu, Z1
Wu, C1
Liao, M1
Sun, Y1
Qin, X1
Hu, Y1
Li, L1
Peng, T1
Li, Z1
Mo, Z1
Morsy, MA1
Ibrahim, MA1
Abd-Elghany, MI1
Nakagawa, T4
Shafiu, M1
Sundaram, S1
Le, M3
Ishimoto, T5
Sautin, YY4
Cai, W1
Wu, X1
Zhang, B1
Miao, L1
Sun, YP1
Zou, Y1
Yao, H1
Liu, PJ1
Ma, F1
Lou, HP1
Zhu, YN1
Chen, Y2
Choi, YJ2
Shin, HS1
Choi, HS1
Park, JW1
Jo, I1
Oh, ES1
Lee, KY1
Lee, BH1
Kang, DH2
Xu, C6
Zhao, Y1
Uyanik, M1
Sertoglu, E1
Kayadibi, H1
Schwimmer, JB2
Zepeda, A1
Newton, KP1
Xanthakos, SA1
Behling, C1
Hallinan, EK1
Donithan, M1
Tonascia, J2
Agilli, M1
Aydin, FN1
Wan, X1
Lin, Y1
Lu, C1
Li, D1
Sang, J1
Liu, X1
Ortega-Cortes, R1
Trujillo, X1
Hurtado López, EF1
López Beltrán, AL1
Colunga Rodríguez, C1
Barrera-de Leon, JC1
Tlacuilo-Parra, A1
Ercin, CN1
Gurel, H1
Dogru, T2
Gugliucci, A1
Li, YY1
Yu, Y1
Wang, F1
Zhang, HQ1
Zhao, M1
Liu, L1
Gao, L1
Zhao, JJ1
Wei, TY1
Wang, CC1
Campos, V1
Despland, C1
Brandejsky, V1
Kreis, R1
Schneiter, P1
Boesch, C1
Tappy, L1
Miao, M3
Suzuki, I1
Yamauchi, T1
Onuma, M1
Nozaki, S1
Mu, W1
Roncal, C1
Abdelmalek, M1
Reungjui, S1
Lan, HY1
Yu, X1
Lee, YJ1
Lee, HR1
Lee, JH1
Shin, YH1
Shim, JY1
Loomba, R1
Rao, F1
Zhang, L1
Khandrika, S1
Ziegler, MG1
Brenner, DA1
O'Connor, DT1
Kuo, CF1
Yu, KH1
Luo, SF1
Chiu, CT1
Ko, YS1
Hwang, JS1
Tseng, WY1
Chang, HC1
Chen, HW1
See, LC1
Ji, HF1
Shen, L1
Xu, CF1
Yu, CH1
Sa, XY1
Li, YM1
Ryu, S1
Chang, Y1
Kim, SG1
Cho, J1
Guallar, E1
Katsiki, N1
Athyros, VG1
Karagiannis, A1
Mikhailidis, DP1
Hwang, IC1
Suh, SY1
Suh, AR1
Ahn, HY1
Kim, JH2
Kim, SY1
Jung, ES1
Jung, SW1
Koo, JS1
Yeon, JE1
Kwon, SY1
Lee, SW1
Byun, KS1
Lee, CH1
Petta, S2
Cammà, C2
Cabibi, D2
Di Marco, V1
Craxì, A2
Genc, H1
Tapan, S1
Bagci, S1
White, JS1
Vos, MB1
Colvin, R1
Belt, P1
Molleston, JP1
Murray, KF1
Rosenthal, P1
Unalp, A1
Lavine, JE1
Macaluso, FS1
Marco, VD1
Keenan, T1
Blaha, MJ1
Nasir, K1
Silverman, MG1
Tota-Maharaj, R1
Carvalho, JA1
Conceição, RD1
Blumenthal, RS1
Santos, RD1
Kubes, P1
Mehal, WZ1
Xia, MF1
Lin, HD1
Li, XM1
Yan, HM1
Bian, H1
Chang, XX1
He, WY1
Jeekel, J1
Hofman, A1
Cicerchi, C3
Li, N3
Marek, G1
Duranay, M1
Schreiner, G2
Rodriguez-Iturbe, B2
Sirota, JC1
McFann, K1
Targher, G1
Chonchol, M1
Jalal, DI1
Garcia, GE1
Thomas, JB1
Rivard, CJ2
Hunter, B2
Thomas, J1
Hodges, RS1
Mant, CT1
Panahi, Y1
Ghamarchehreh, ME1
Beiraghdar, F1
Zare, R1
Jalalian, HR1
Sahebkar, A1
Tapia, E1
Cristóbal, M1
García-Arroyo, FE1
Soto, V1
Monroy-Sánchez, F1
Pacheco, U1
Cruz-Robles, D1
Madero, M1
COLMAN, RW1
SHEIN, HM1
Isselbacher, KJ1
Greenberger, NJ1
GIULIANI, A1
SAMMARTINO, V1
Zhang, XY1
Kuang, CB1
Venturi, C1
Zoppini, G1
Zamboni, C1
Muggeo, M1
Loria, P2
Lonardo, A2
Lombardini, S1
Carulli, L1
Verrone, A1
Ganazzi, D2
Rudilosso, A1
D'Amico, R1
Bertolotti, M2
Carulli, N2
García-Ruiz, I1
Rodríguez-Juan, C1
Díaz-Sanjuan, T1
del Hoyo, P1
Colina, F1
Muñoz-Yagüe, T1
Solís-Herruzo, JA1
Fenkci, S1
Rota, S1
Sabir, N1
Akdag, B1
Groen, J1
Baba, T1
Amasaki, Y1
Soda, M1
Hida, A1
Imaizumi, M1
Ichimaru, S1
Nakashima, E1
Seto, S1
Yano, K1
Akahoshi, M1
Renger, F1
Yamazaki, K1
Murata, M1
Coffey, CG1
Tobe, K1
Ogura, T1
Tsukamoto, C1
Imai, A1
Matsuura, K1
Iwasaki, Y1
Shimomura, H1
Higashi, T1
Tsuji, T1
Davail, S1
Guy, G1
André, J1
Hermier, D1
Hoo-Paris, R1
Leonardi, F1
Borsatti, A1
Neri, P1
Pulvirenti, M1
Verrone, AM1
Bagni, A1
Henninces, D1
Förster, H1
Weiss, V1
Lomessy, A1
Kolenda, KD1
Young, SR1
Stoelting, RK1
Peterson, C1
Madura, JA1
Lieber, CS2
Hsiung, R1
Hasselmann, M1
Lutun, P1
Gordji, M1
Jaross, W1
Hanefeld, M1
Schentke, KU1
Trübsbach, A1
Stötzner, H1
Leonhardt, W1
Herrmann, V1
Fuchs, R1
Peschel, G1
Scheffler, W1
Sinclair, HM1
Michelis, MF1
Warms, PC1
Fusco, RD1
Davis, BB1
Bannister, DW1
Burns, AB1
Evans, AJ1
Martindale, L1
O'Sullivan, WJ1
Babucke, G1
Mertz, DP6
Nitsan, Z1
Nir, I1
Dror, Y1
Bruckental, I1
Manes, JL1
Taylor, HB1
Starkloff, GB1
Baddeley, M1
Henninges, D3
Sulzberger, I1
Klöpfer, M1
Zaar, I1
Klöpfer-Zaar, M1
Thieme, G1
Scheier, CA1
Tremel, R1
Pohl, W1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Genetic-specific Effects of Fructose on Liver Lipogenesis[NCT03783195]15 participants (Actual)Interventional2019-01-25Completed
Allopurinol Versus Febuxostat: A New Approach for Management of Hepatic Steatosis in Metabolic-Associated Fatty Liver Disease[NCT05474560]Phase 490 participants (Actual)Interventional2022-01-01Completed
Effects of 4-month Therapy of Levothyroxine on Non-Alcoholic Fatty Liver Disease (NAFLD) and Diabetes Control in Diabetic Patients[NCT03281083]Phase 229 participants (Actual)Interventional2014-03-28Terminated (stopped due to Difficult recruitment and end of funding.)
Insulin Resistance in Nonalcoholic Fatty Liver Disease: A Case Control Study[NCT00637520]29 participants (Actual)Observational2007-07-31Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

15 reviews available for uric acid and Fatty Liver

ArticleYear
Uric Acid as a Cause of the Metabolic Syndrome.
    Contributions to nephrology, 2018, Volume: 192

    Topics: AMP Deaminase; Animals; Diabetes Mellitus; Dietary Sugars; Fatty Liver; Fructose; Humans; Hypertensi

2018
Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people.
    Advances in nutrition (Bethesda, Md.), 2013, Mar-01, Volume: 4, Issue:2

    Topics: Beverages; Diabetes Mellitus; Diet; Dietary Sucrose; Fatty Liver; Fructose; Glucose; Gout; Humans; L

2013
Carbohydrate intake and nonalcoholic fatty liver disease.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:4

    Topics: Animals; Beverages; Clinical Trials as Topic; Dietary Carbohydrates; Fatty Liver; Fibrosis; Humans;

2013
Sugar, uric acid, and the etiology of diabetes and obesity.
    Diabetes, 2013, Volume: 62, Issue:10

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Sucrose; Disease Models, Animal

2013
Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders?
    Drugs of today (Barcelona, Spain : 1998), 2009, Volume: 45, Issue:5

    Topics: Allopurinol; Enzyme Inhibitors; Fatty Liver; Humans; Liver Diseases; Metabolic Syndrome; Mucositis;

2009
The effect of fructose on renal biology and disease.
    Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:12

    Topics: Diabetes Mellitus; Diet; Dietary Carbohydrates; Fatty Liver; Female; Fructose; Humans; Hypertension;

2010
Hyperuricaemia and non-alcoholic fatty liver disease (NAFLD): a relationship with implications for vascular risk?
    Current vascular pharmacology, 2011, Volume: 9, Issue:6

    Topics: Cardiovascular Diseases; Chronic Disease; Evidence-Based Medicine; Fatty Liver; Humans; Hyperuricemi

2011
Sterile inflammation in the liver.
    Gastroenterology, 2012, Volume: 143, Issue:5

    Topics: Acetaminophen; Adenosine Triphosphate; Caspase 1; Chemical and Drug Induced Liver Injury; Chemotaxis

2012
METABOLIC EFFECTS OF ALCOHOL ON THE LIVER.
    The New England journal of medicine, 1964, 02-20, Volume: 270

    Topics: Alcoholism; Carbohydrate Metabolism; Catecholamines; Ethanol; Fatty Liver; Folic Acid; Gastrointesti

1964
[Alcohol and the liver].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1981, Aug-15, Volume: 36, Issue:16

    Topics: Acetaldehyde; Carbohydrate Metabolism; Enzyme Induction; Fatty Liver; gamma-Glutamyltransferase; Hep

1981
[Complication of childhood obesity].
    Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53 Suppl

    Topics: Body Mass Index; Cardiovascular Diseases; Child; Diabetes Mellitus, Type 2; Fatty Liver; Female; Hum

1995
Alcohol and the liver: metabolism of ethanol, metabolic effects and pathogenesis of injury.
    Acta medica Scandinavica. Supplementum, 1985, Volume: 703

    Topics: Acetaldehyde; Acetates; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcoholism; Animals; Blood G

1985
Nutritional aspects of alcohol consumption.
    The Proceedings of the Nutrition Society, 1972, Volume: 31, Issue:2

    Topics: Alcoholism; Animals; Cholecalciferol; Choline Deficiency; Ethanol; Fatty Liver; Glutamates; Humans;

1972
Metabolic effects produced by alcohol in the liver and other tissues.
    Advances in internal medicine, 1968, Volume: 14

    Topics: Acetaldehyde; Acetates; Alcoholism; Coenzymes; Deficiency Diseases; Dietary Carbohydrates; Enzymes;

1968
Orotic acid.
    Australian and New Zealand journal of medicine, 1973, Volume: 3, Issue:4

    Topics: Allopurinol; Anemia, Pernicious; Animals; Azauridine; Carboxy-Lyases; Fatty Liver; Female; Humans; I

1973

Trials

3 trials available for uric acid and Fatty Liver

ArticleYear
Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial.
    Nutrients, 2017, Feb-27, Volume: 9, Issue:3

    Topics: Adult; Blood Glucose; Body Mass Index; Diet; Fatty Acids, Nonesterified; Fatty Liver; Female; Glucag

2017
Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial.
    Hepato-gastroenterology, 2012, Volume: 59, Issue:119

    Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Antioxidants; Aspartate Aminotransferases;

2012
[Clinical observation on treatment of nonalcoholic fatty liver disease complicating hyperuricemia by Zhifang I Decoction].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2004, Volume: 2, Issue:4

    Topics: Adult; Aged; Alanine Transaminase; Drugs, Chinese Herbal; Fatty Liver; Female; gamma-Glutamyltransfe

2004

Other Studies

89 other studies available for uric acid and Fatty Liver

ArticleYear
Circulating level of fatty acid-binding protein 4 is an independent predictor of metabolic dysfunction-associated fatty liver disease in middle-aged and elderly individuals.
    Journal of diabetes investigation, 2022, Volume: 13, Issue:5

    Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fatty Acid

2022
Timely identification and successful treatment of acute fatty liver of pregnancy without obvious clinical symptoms: Case reports.
    Medicine, 2022, Feb-04, Volume: 101, Issue:5

    Topics: Adult; Blood Coagulation Disorders; Fatty Liver; Female; Humans; Hypoglycemia; Infant, Newborn; Preg

2022
Fatty liver index for hyperuricemia diagnosis: a community-based cohort study.
    BMC endocrine disorders, 2022, Apr-30, Volume: 22, Issue:1

    Topics: Adult; Cohort Studies; Fatty Liver; Humans; Hyperuricemia; Incidence; Uric Acid

2022
Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Cross-Sectional Studies; Elasticity Imaging Techniques; Fatty Liver; Female; Humans; Liver Cirrhosis

2022
The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease.
    Hepatology international, 2022, Volume: 16, Issue:5

    Topics: Animals; Fatty Acids; Fatty Liver; Genotype; Glucose Transport Proteins, Facilitative; Humans; Male;

2022
Association between serum uric acid to high density lipoprotein-cholesterol ratio and arterial stiffness in a Japanese population.
    Medicine, 2023, Aug-04, Volume: 102, Issue:31

    Topics: Adult; Aged; Aged, 80 and over; Ankle Brachial Index; Cholesterol, HDL; Disease Progression; East As

2023
Hepatic Steatosis in Lean Patients: Risk Factors and Impact on Mortality.
    Digestive diseases and sciences, 2020, Volume: 65, Issue:9

    Topics: Adult; Body Mass Index; Elasticity Imaging Techniques; Fatty Liver; Female; Humans; Hyperuricemia; L

2020
Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.
    Scientific reports, 2020, 01-21, Volume: 10, Issue:1

    Topics: Allopurinol; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Febuxostat; Hyperuricemia

2020
Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China.
    International journal of environmental research and public health, 2020, 03-11, Volume: 17, Issue:6

    Topics: Adult; Aged; Blood Glucose; Body Mass Index; China; Cross-Sectional Studies; Fatty Liver; Female; He

2020
Serum C-X-C motif chemokine ligand 14 levels are associated with serum C-peptide and fatty liver index in type 2 diabetes mellitus patients.
    Journal of diabetes investigation, 2021, Volume: 12, Issue:6

    Topics: Adiponectin; Age Factors; Aged; Alanine Transaminase; Biomarkers; Body Mass Index; C-Peptide; Chemok

2021
Prolonged Changes in Hepatic Mitochondrial Activity and Insulin Sensitivity by High Fructose Intake in Adolescent Rats.
    Nutrients, 2021, Apr-19, Volume: 13, Issue:4

    Topics: Alanine Transaminase; Animals; Body Composition; Ceramides; Diet, Carbohydrate Loading; Disease Mode

2021
CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress.
    Tissue & cell, 2021, Volume: 72

    Topics: Adipokines; Animals; Fatty Acid Synthases; Fatty Liver; Feeding Behavior; Fructose; Lipids; Male; Ox

2021
Computerized Tomography Based Diagnosis of Visceral Obesity and Hepatic Steatosis is Associated with Low Urine pH.
    The Journal of urology, 2017, Volume: 198, Issue:5

    Topics: Adult; Aged; Fatty Liver; Female; Humans; Hydrogen-Ion Concentration; Intra-Abdominal Fat; Kidney Ca

2017
[The Preliminary Investigation of GLP-1 Receptor Agonist on Liver Steatosis in Obese Mice].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2017, Volume: 48, Issue:1

    Topics: Animals; Diet, High-Fat; Exenatide; Fatty Liver; Glucagon-Like Peptide-1 Receptor; Insulin Resistanc

2017
Fatty liver index is associated to pulse wave velocity in healthy subjects: Data from the Brisighella Heart Study.
    European journal of internal medicine, 2018, Volume: 53

    Topics: Adult; Aged; Body Mass Index; Fatty Liver; Female; Healthy Volunteers; Humans; Italy; Linear Models;

2018
Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver.
    Scientific reports, 2018, 08-06, Volume: 8, Issue:1

    Topics: Adult; Body Mass Index; Cohort Studies; Fatty Liver; Female; Humans; Male; Middle Aged; Retrospectiv

2018
Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD).
    Revista espanola de enfermedades digestivas, 2019, Volume: 111, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Body Mass Index; Chol

2019
Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women.
    Annals of nutrition & metabolism, 2013, Volume: 62, Issue:2

    Topics: Adult; Alanine Transaminase; Asian People; Aspartate Aminotransferases; Body Mass Index; Cholesterol

2013
Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Adult; Aged; Asian People; China; Confidence Intervals; Diabetes Mellitus; Fatty Liver; Humans; Line

2013
Dimethyl dimethoxy biphenyl dicarboxylate attenuates hepatic and metabolic alterations in high fructose-fed rats.
    Toxicology and industrial health, 2016, Volume: 32, Issue:1

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Blood Glu

2016
Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China.
    Arquivos brasileiros de endocrinologia e metabologia, 2013, Volume: 57, Issue:8

    Topics: Adult; Body Mass Index; China; Fatty Liver; Feeding Behavior; Female; Humans; Hyperuricemia; Life St

2013
Relationship between serum uric acid levels and hepatic steatosis in non-obese postmenopausal women.
    Climacteric : the journal of the International Menopause Society, 2014, Volume: 17, Issue:6

    Topics: Adult; Aged; Blood Pressure; Body Mass Index; China; Cross-Sectional Studies; Diabetes Mellitus, Typ

2014
Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.
    Laboratory investigation; a journal of technical methods and pathology, 2014, Volume: 94, Issue:10

    Topics: Acetyl-CoA Carboxylase; Animals; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress;

2014
The significance of serum xanthine oxidoreductase in patients with nonalcoholic fatty liver disease.
    Clinical laboratory, 2014, Volume: 60, Issue:8

    Topics: Adult; Anthropometry; Case-Control Studies; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Ass

2014
Patient selection bias may derive from the improper usage of diagnostic methods.
    Climacteric : the journal of the International Menopause Society, 2014, Volume: 17, Issue:6

    Topics: Fatty Liver; Female; Humans; Postmenopause; Uric Acid

2014
Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Adolescent; Blood Pressure Determination; Chi-Square Distribution; Child; Child, Preschool; Choleste

2014
Association between serum uric acid and nonalcoholic fatty liver disease.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016, Volume: 115, Issue:2

    Topics: Fatty Liver; Humans; Liver; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism.
    Journal of hepatology, 2016, Volume: 64, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Fatty Liver; Hep G2 Cells; Hepatocytes; Humans; Inflammasome

2016
Models Predictive of Metabolic Syndrome Components in Obese Pediatric Patients.
    Archives of medical research, 2016, Volume: 47, Issue:1

    Topics: Adolescent; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Child; Cross-Sectional Studies;

2016
Uric acid in nonalcoholic fatty liver disease.
    European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:5

    Topics: Fatty Liver; Humans; Liver; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance.
    Medical hypotheses, 2016, Volume: 93

    Topics: Adenosine Monophosphate; Adenylate Kinase; Allosteric Site; AMP-Activated Protein Kinases; Animals;

2016
[Investigation of metabolic disorders in patients with familial fatty liver disease and their first-degree relatives].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2016, Volume: 24, Issue:6

    Topics: Blood Glucose; Body Mass Index; China; Family; Fatty Liver; Humans; Hyperglycemia; Metabolic Syndrom

2016
Uncovered issues in the association between uric acid and nonalcoholic fatty liver disease.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016, Volume: 115, Issue:11

    Topics: Fatty Liver; Humans; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study.
    Journal of hepatology, 2009, Volume: 50, Issue:5

    Topics: Adult; Biomarkers; China; Cross-Sectional Studies; Fatty Liver; Female; Humans; Male; Metabolic Synd

2009
Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver.
    European journal of nutrition, 2010, Volume: 49, Issue:1

    Topics: Animals; Body Fat Distribution; Chemokine CCL2; Dietary Carbohydrates; Dietary Sucrose; Energy Intak

2010
Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults.
    Clinical chemistry and laboratory medicine, 2010, Volume: 48, Issue:2

    Topics: Adult; Age Factors; Aged; Blood Glucose; Blood Pressure; Body Mass Index; Cities; Exercise; Fatty Li

2010
Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins.
    Gastroenterology, 2010, Volume: 139, Issue:3

    Topics: Adult; Biomarkers; Blood Pressure; California; Cross-Sectional Studies; Dyslipidemias; Fatty Liver;

2010
Gout and risk of non-alcoholic fatty liver disease.
    Scandinavian journal of rheumatology, 2010, Volume: 39, Issue:6

    Topics: Adult; Aged; Body Mass Index; Cross-Sectional Studies; Fatty Liver; Female; Glomerular Filtration Ra

2010
High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study.
    PloS one, 2010, Jul-14, Volume: 5, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Fatty Liver; Female; Humans; Male; Middle Aged; Prospective Studies;

2010
Uric acid potentially links fatty liver and high blood pressure.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:4

    Topics: Fatty Liver; Humans; Hypertension; Hyperuricemia; Logistic Models; Uric Acid

2010
Hypouricemic therapy: a novel potential therapeutic option for nonalcoholic fatty liver disease.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:5

    Topics: Animals; Dietary Fats; Disease Models, Animal; Fatty Liver; Gerbillinae; Humans; Uric Acid

2010
Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men.
    Metabolism: clinical and experimental, 2011, Volume: 60, Issue:6

    Topics: Adult; Aging; Alcohol Drinking; Blood Chemical Analysis; Body Mass Index; Fatty Liver; Follow-Up Stu

2011
The relationship between normal serum uric acid and nonalcoholic fatty liver disease.
    Journal of Korean medical science, 2011, Volume: 26, Issue:3

    Topics: Adult; Fatty Liver; Female; Humans; Liver Function Tests; Logistic Models; Male; Middle Aged; Non-al

2011
Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese.
    Clinical endocrinology, 2011, Volume: 75, Issue:2

    Topics: Aged; Asian People; Body Mass Index; Cross-Sectional Studies; Fatty Liver; Humans; Non-alcoholic Fat

2011
Carotid intima-media thickness is increased not only in non-alcoholic fatty liver disease patients but also in alcoholic fatty liver patients.
    Digestion, 2011, Volume: 84, Issue:2

    Topics: Adult; Alanine Transaminase; Alcohol Drinking; Analysis of Variance; Aspartate Aminotransferases; Bi

2011
Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease.
    Alimentary pharmacology & therapeutics, 2011, Volume: 34, Issue:7

    Topics: Adult; Anthropometry; Biomarkers; Biopsy; Cohort Studies; Fatty Liver; Female; Humans; Hyperuricemia

2011
Hyperuricemia in non-alcoholic fatty liver disease.
    Alimentary pharmacology & therapeutics, 2011, Volume: 34, Issue:8

    Topics: Fatty Liver; Female; Humans; Hyperuricemia; Male; Uric Acid

2011
Uric acid as a surrogate for fructose intake is not supported.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 54, Issue:3

    Topics: Diet; Fatty Liver; Female; Humans; Liver; Male; Uric Acid; Vitamin E; Vitamin E Deficiency

2012
Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 54, Issue:1

    Topics: Adolescent; Ascorbic Acid; Child; Cross-Sectional Studies; Diet; Dietary Sucrose; Energy Intake; Fat

2012
Hyperuricaemia: another metabolic feature affecting the severity of chronic hepatitis because of HCV infection.
    Liver international : official journal of the International Association for the Study of the Liver, 2012, Volume: 32, Issue:9

    Topics: Biomarkers; Biopsy; Fatty Liver; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Hyperuricemia; M

2012
Relation of uric acid to serum levels of high-sensitivity C-reactive protein, triglycerides, and high-density lipoprotein cholesterol and to hepatic steatosis.
    The American journal of cardiology, 2012, Dec-15, Volume: 110, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cholesterol, HDL; Fatty Liver; Femal

2012
Renal function-dependent association of serum uric acid with metabolic syndrome and hepatic fat content in a middle-aged and elderly Chinese population.
    Clinical and experimental pharmacology & physiology, 2012, Volume: 39, Issue:11

    Topics: Aged; Asian People; Cohort Studies; Cross-Sectional Studies; Fatty Liver; Female; Glomerular Filtrat

2012
Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.
    The Journal of biological chemistry, 2012, Nov-23, Volume: 287, Issue:48

    Topics: Fatty Liver; Fructose; Hep G2 Cells; Humans; Lipogenesis; Mitochondria; Oxidative Stress; Triglyceri

2012
Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:3

    Topics: Adult; Aged; Aspartate Aminotransferases; Cholesterol, HDL; Cross-Sectional Studies; Fatty Liver; Fe

2013
Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Allopurinol; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Enzyme Inhibitors

2012
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Adenylate Kinase; AMP Deaminase; Animals; Carbon-Carbon Double Bond Isomerases; Enzyme Activation; F

2012
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats.
    American journal of physiology. Renal physiology, 2013, Mar-15, Volume: 304, Issue:6

    Topics: Animals; Beverages; Fatty Liver; Fructokinases; Fructose; Glucose; Hypertrophy; Hyperuricemia; Insul

2013
Leukemoid reaction, hyperuricemia and severe hyperpyrexia complicating a fatal case of acute fatty liver of the alcoholic.
    Annals of internal medicine, 1962, Volume: 57

    Topics: Alcoholism; Fatty Liver; Fever; Humans; Hyperuricemia; Leukemia; Leukemoid Reaction; Liver Diseases;

1962
[CLINICAL CONTRIBUTION TO THE STUDY OF A NEW SYNTHETIC ANTICHOLESTEREMIC AGENT: BETA-BENZALBUTYRRAMIDE].
    Minerva medica, 1963, Oct-06, Volume: 54

    Topics: Amides; Anticholesteremic Agents; Arthritis; Arthritis, Rheumatoid; Asthma; Butyrates; Cholelithiasi

1963
Insulin sensitivity and hepatic steatosis in obese subjects with normal glucose tolerance.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2004, Volume: 14, Issue:4

    Topics: Adult; Alanine Transaminase; Blood Glucose; Body Mass Index; Cholesterol; Cohort Studies; Fatty Live

2004
Gallstone disease in non-alcoholic fatty liver: prevalence and associated factors.
    Journal of gastroenterology and hepatology, 2005, Volume: 20, Issue:8

    Topics: Age Factors; Apolipoproteins B; Biopsy; Cholecystolithiasis; Cholesterol; Fatty Liver; Female; Gallb

2005
Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice.
    Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:3

    Topics: Animals; Antibodies; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; F

2006
Ultrasonographic and biochemical evaluation of visceral obesity in obese women with non-alcoholic fatty liver disease.
    European journal of medical research, 2007, Feb-26, Volume: 12, Issue:2

    Topics: Adult; Age Factors; Alanine Transaminase; Aspartate Aminotransferases; Blood Glucose; Blood Pressure

2007
An Experimental Syndrome of Fatty Liver, Uric Acid Kidney Stones, and Acute Pancreatic Necrosis Produced in Dogs by Exclusive Feeding of Bacon.
    Science (New York, N.Y.), 1948, Apr-23, Volume: 107, Issue:2782

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dogs; Doxorubicin; Fatty Liver;

1948
Fatty liver and uric acid levels predict incident coronary heart disease but not stroke among atomic bomb survivors in Nagasaki.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:9

    Topics: Aged; Coronary Disease; Fatty Liver; Female; Humans; Japan; Male; Middle Aged; Nuclear Weapons; Pros

2007
Pre-eclampsia: excessive activation of a G protein-associated receptor?
    Medical hypotheses, 1995, Volume: 44, Issue:5

    Topics: Arachidonic Acids; Calcium; Endothelium, Vascular; Fatty Liver; Female; GTP-Binding Proteins; Humans

1995
Relationship between serum leptin and fatty liver in Japanese male adolescent university students.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:11

    Topics: Adipose Tissue; Adolescent; Adult; Alanine Transaminase; Analysis of Variance; Aspartate Aminotransf

1999
Metabolism in two breeds of geese with moderate or large overfeeding induced liver-steatosis.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2000, Volume: 126, Issue:1

    Topics: Animals; Blood Glucose; Body Composition; Body Weight; Eating; Fatty Liver; Food Deprivation; Geese;

2000
Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2002, Volume: 34, Issue:3

    Topics: Case-Control Studies; Fatty Liver; Female; Humans; Insulin; Insulin Resistance; Logistic Models; Mal

2002
[Gout in young subjects].
    Minerva medica, 1977, Mar-30, Volume: 68, Issue:15

    Topics: Adolescent; Adult; Age Factors; Angina Pectoris; Back Pain; Diabetes Complications; Fatty Liver; Fem

1977
[Side effects of sugar substitutes].
    Deutsche zahnarztliche Zeitschrift, 1977, Volume: 32, Issue:5 Suppl 1

    Topics: Administration, Oral; Diarrhea; Fatty Liver; Glucose; Glycerol; Humans; Insulin; Insulin Secretion;

1977
[Alcoholism and anesthesia problems].
    Revue medicale de la Suisse romande, 1979, Volume: 99, Issue:1

    Topics: Alcoholism; Anesthesia; Brain; Ethanol; Fatty Liver; Humans; Lactates; Liver; Liver Cirrhosis; Uric

1979
[The "alcohol-syndrome" from internal medical view (author's transl)].
    Medizinische Klinik, 1977, May-13, Volume: 72, Issue:19

    Topics: Adult; Age Factors; Alcoholism; Anxiety; Fatty Liver; Humans; Hyperlipidemias; Hypertension; Obesity

1977
Anesthetic biotransformation and renal function in obese patients during and after methoxyflurane or halothane anesthesia.
    Anesthesiology, 1975, Volume: 42, Issue:4

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Inhalation; Biopsy, Needle; Biotransformation; Fatty Liver

1975
[Acute fatty liver of pregnancy. Diagnostic value of hyperuricemia in the pre-jaundice stage].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1988, Volume: 17, Issue:7

    Topics: Acute Disease; Adult; Fatty Liver; Female; Humans; Pregnancy; Pregnancy Complications; Uric Acid

1988
[Changes in metabolic parameters, especially in fat metabolism, in chronic alcoholics during clinical alcohol deficiency].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Apr-01, Volume: 27, Issue:7

    Topics: Adult; Alcoholism; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Biopsy; Blood Prote

1972
[8 years of SGPT screening at the District Institute for Blood Donation and Transfusion Services in Karl-Marx-Stadt].
    Folia haematologica (Leipzig, Germany : 1928), 1973, Volume: 99, Issue:1

    Topics: Adult; Alanine Transaminase; Biopsy; Blood Donors; Clinical Enzyme Tests; Diabetes Mellitus; Fatty L

1973
Hypouricemia and hyperuricosuria in Laennec cirrhosis.
    Archives of internal medicine, 1974, Volume: 134, Issue:4

    Topics: Alcoholism; Bilirubin; Creatinine; Fatty Liver; Humans; Kidney Function Tests; Kidney Tubules; Liver

1974
Interference by urate in the determination of plasma glucose.
    British poultry science, 1974, Volume: 15, Issue:4

    Topics: Animals; Blood Glucose; Chickens; Fatty Liver; Female; Kidney Diseases; Male; Methods; Poultry Disea

1974
[Changes between 1948 and 1970 in the epidemiology and clinical features of primary gout].
    Deutsche medizinische Wochenschrift (1946), 1973, Feb-02, Volume: 98, Issue:5

    Topics: Adult; Age Factors; Aged; Alcohol Drinking; Blood Protein Disorders; Diabetes Complications; Fatty L

1973
The effect of forced feeding and of dietary protein level on enzymes associated with digestion, protein and carbohydrate metabolism in geese.
    Poultry science, 1973, Volume: 52, Issue:2

    Topics: Amylases; Animal Feed; Animals; Arginase; Blood Urea Nitrogen; Chymotrypsin; Dietary Carbohydrates;

1973
Relationship between hepatic morphology and clinical and biochemical findings in morbidly obese patients.
    Journal of clinical pathology, 1973, Volume: 26, Issue:10

    Topics: Adipose Tissue; Adolescent; Adult; Age Factors; Carbohydrate Metabolism; Cell Nucleus; Fatty Liver;

1973
Surgical treatment of obesity.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:11

    Topics: Blood Sedimentation; Calcium; Cholesterol; Diarrhea; Fatty Liver; Folic Acid; Humans; Ileostomy; Iro

1973
[Gout, diabetes mellitus and fatty liver].
    Munchener medizinische Wochenschrift (1950), 1972, Feb-04, Volume: 114, Issue:5

    Topics: Adult; Arteriosclerosis; Body Weight; Diabetes Complications; Fatty Liver; Female; Gout; Humans; Hyp

1972
[Uric acid abnormalities in juveniles. Peculiarities of the clinical picture].
    Munchener medizinische Wochenschrift (1950), 1971, Mar-26, Volume: 113, Issue:13

    Topics: Adolescent; Adult; Diabetes Complications; Diagnosis, Differential; Fatty Liver; Gout; Humans; Hyper

1971
[Diabetes mellitus, hyperlipemia, fatty liver, hypertension in primary gout and their influencing by benzbromaronum].
    Munchener medizinische Wochenschrift (1950), 1970, Feb-06, Volume: 112, Issue:6

    Topics: Adult; Benzofurans; Blood Glucose; Blood Sedimentation; Colchicine; Creatinine; Diabetes Mellitus; E

1970
[Alterations of lipid metabolism in primary gout and hyperuircemia].
    Deutsche medizinische Wochenschrift (1946), 1971, Mar-19, Volume: 96, Issue:12

    Topics: Adult; Aged; Blood Glucose; Cholesterol; Diabetes Mellitus; Fatty Acids; Fatty Acids, Nonesterified;

1971
[Gout in young patients].
    Les Cahiers de medecine, 1971, May-15, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Age Factors; Diabetes Complications; Fatty Liver; Gout; Humans; Hyperlipidemias;

1971
[Liver pathology in gout].
    Medizinische Klinik, 1971, May-21, Volume: 66, Issue:21

    Topics: Adult; Biopsy; Blood Glucose; Blood Protein Electrophoresis; Body Weight; Cholesterol; Diabetes Comp

1971