Page last updated: 2024-10-20

uric acid and Fatty Liver, Nonalcoholic

uric acid has been researched along with Fatty Liver, Nonalcoholic in 171 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
"Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease."8.93Uric acid in metabolic syndrome: From an innocent bystander to a central player. ( Jensen, T; Johnson, RJ; Kanbay, M; Lanaspa, MA; Le, M; Nakagawa, T; Rivard, C; Roncal-Jimenez, C; Solak, Y, 2016)
"An excess circulating uric acid level, even within the normal range, is always comorbid with metabolic syndrome (MS), several of its components, and nonalcoholic fatty liver disease (NAFLD), which was regarded as hepatic manifestation of MS; however, these associations remain controversial."8.91Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-Analysis of Prospective Studies. ( Li, X; Sun, L; Yang, Z; Yu, C; Yuan, H; Zhang, Z; Zhao, C; Zhu, X, 2015)
"Emerging evidence has shown that serum uric acid (SUA) elevation might cause metabolic derangements, including metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD); however, magnitude of the risk has not been quantified."8.91Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: A Meta-analysis of Prospective Studies. ( Liu, Z; Que, S; Zheng, S; Zhou, L, 2015)
"The association between serum uric acid (SUA) and mortality from cardiovascular diseases (CVDs) in nonalcoholic fatty liver disease (NAFLD) participants remains uncertain."8.31Association of serum uric acid with all-cause and cardiovascular mortality among adults with nonalcoholic fatty liver disease. ( He, P; Li, H; Liu, C; Liu, M; Qin, X; Wu, Q; Yang, S; Ye, Z; Zhang, Y; Zhang, Z; Zhou, C, 2023)
" We investigated whether uric acid (UA) and the macrophage marker soluble form of cysteine scavenger receptor CD163 (sCD163) can be used as biomarkers for deteriorated metabolism or pediatric MAFLD in children with overweight or obesity."8.31Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity. ( Dalstrup Jakobsen, D; Kristensen, NM; Meldgaard Bruun, J; Orry, S, 2023)
"To study the associations of non-alcoholic fatty liver disease (NAFLD), chronic kidney disease (CKD), and serum uric acid (SUA) in patients with post-myocardial infarction (MI) patients, and the relationship of SUA with 12-year mortality risk."8.31Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction. ( Boersma, E; Geleijnse, JM; Heerkens, L; Kardys, I; van Westing, AC; Voortman, T, 2023)
"Non-alcoholic fatty liver disease (NAFLD) and serum uric acid (SUA) levels are risk factors for developing cardiovascular disease (CVD)."8.12The Association between Serum Uric Acid Levels and 10-Year Cardiovascular Disease Risk in Non-Alcoholic Fatty Liver Disease Patients. ( Hwang, J; Kang, K; Kim, K; Lee, JM; Sheol, H; Shin, J; Sim, Y; Yang, T, 2022)
"Increasing evidence has supported that serum uric acid (SUA), alanine aminotransferase (ALT) and waist circumference (WC) are associated with the occurrence of non-alcoholic fatty liver disease (NAFLD)."8.12A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study. ( Chen, Y; Ding, Y; Fan, H; Tang, Z; Wang, H; Wang, J; Wang, M; Zhang, L; Zhang, R; Zhang, W, 2022)
"Serum uric acid (SUA) and heavy metals are closely related to non-alcoholic fatty liver disease (NAFLD)."8.12Conjunctional Relationship between Serum Uric Acid and Serum Nickel with Non-Alcoholic Fatty Liver Disease in Men: A Cross-Sectional Study. ( Jiang, J; Liu, C; Liu, W; Wang, Y; Wu, W; Yang, Z; Zhang, G, 2022)
" Additionally, anthropometric parameters (height, weight, BMI, waist circumference, hip circumference) such as lab data including lipid profile (triglycerides, HDL, LDL), liver function parameters (ALT, AST), uric acid, glucose metabolism (fasting insulin and glucagon, HbA1c, glucose 120 min) and indices evaluating insulin resistance (HIRI, SPISE, HOMA-IR, WBISI) were measured."8.12Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease. ( Ahlström, H; Bergsten, P; Forslund, A; Kullberg, J; Manell, H; Mangge, H; Maruszczak, K; Mörwald, K; Pixner, T; Radzikowski, K; Schütz, S; Weghuber, D, 2022)
"The Uric acid to HDL cholesterol ratio of the Non-alcoholic fatty liver disease (13±5%) group was significantly higher compared to the Uric acid to HDL cholesterol ratio of the control (10±4%) group (p<0."8.02The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study. ( Aktas, G; Bilgin, S; Demirkol, ME; Duman, TT; Kahveci, G; Kosekli, MA; Kurtkulagii, O; Tel, BMA, 2021)
"d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver."7.96The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. ( Amézqueta, S; Atienza, L; Casas, J; Hereu, M; Medina, I; Miralles-Pérez, B; Muñoz, S; Ramos-Romero, S; Romeu, M; Torres, JL, 2020)
"It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of non-alcoholic fatty liver disease (NAFLD)."7.96Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study. ( Guo, X; Kang, X; Li, H; Ma, Z; Tao, L; Xu, C; Yang, X; Zhang, S; Zheng, D, 2020)
"Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects."7.85Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults. ( Chen, H; Gong, L; Luo, R; Peng, B; Ren, W; Wang, Y; Zheng, X, 2017)
"The causal relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) has not yet been clarified."7.81Serum uric acid and non-alcoholic fatty liver disease in non-hypertensive Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study. ( Dou, LJ; Gong, Y; Liang, J; Liu, XK; Pei, Y; Qi, L; Qiu, QQ; Yang, MQ; Zou, CY, 2015)
"Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance."7.79Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. ( Gao, Y; Hu, Y; Huang, Z; Li, L; Li, Z; Liang, Z; Liao, M; Lu, Z; Mo, Z; Peng, T; Qin, X; Shi, D; Sun, Y; Tan, A; Wang, M; Wu, C; Xie, Y; Yang, X; Zhang, H; Zhang, S; Zhang, Y, 2013)
"The aim of this study was to compare serum uric acid values in two ethnically distinct Chinese populations: Uyghur, with a high prevalence of nonalcoholic fatty liver disease, and Han, with a lower prevalence."7.79Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China. ( Cai, W; Miao, L; Sun, YP; Wu, X; Yao, H; Zhang, B; Zou, Y, 2013)
"Experimental and observational studies suggest a role for uric acid in non-alcoholic fatty liver disease (NAFLD)."7.79Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. ( Chonchol, M; Jalal, DI; Johnson, RJ; McFann, K; Sirota, JC; Targher, G, 2013)
"The objective of the present study was to determine the relationship between serum uric acid (SUA) level and the presence of nonalcoholic fatty liver disease (NAFLD)."7.77The relationship between normal serum uric acid and nonalcoholic fatty liver disease. ( Ahn, HY; Hwang, IC; Suh, AR; Suh, SY, 2011)
"Curcumin is a dietary natural product with beneficial metabolic effects relevant to the treatment of NAFLD."6.82Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial. ( Jafari, R; Kianpour, P; Mohtashami, R; Panahi, Y; Sahebkar, A; Simental-Mendía, LE, 2016)
"Atorvastatin, which has proven safe in NAFLD/NASH, reduces SUA levels, ameliorates NAFLD/NASH, prevents liver fibrosis, and above all substantially reduces CVD morbidity and mortality in comparison with those on statins but without NAFLD/NASH."6.58Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease? ( Athyros, VG; Giouleme, O; Grammatikos, N; Katsoula, A; Paschos, P; Tsimperidis, A, 2018)
"non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders."6.55Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis. ( Darmawan, G; Hamijoyo, L; Hasan, I, 2017)
"Nonalcoholic fatty liver disease (NAFLD) is a major, worldwide public health problem."6.53Serum uric acid: a new therapeutic target for nonalcoholic fatty liver disease. ( Braddock, M; Liu, WY; Lu, QD; Shi, KQ; Song, D; Sun, DQ; Wu, SJ; Zheng, MH; Zhu, GQ, 2016)
"The risk of NAFLD seemed more pronounced among women (OR 1."6.53High serum uric acid and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis. ( Fan, Y; Wei, F; Zhou, Y, 2016)
"We modeled the relationship between NAFLD and relevant demographic, anthropometric, and biochemical variables."5.91The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population. ( Pirola, CJ; Sookoian, S, 2023)
"The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide."5.91Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population. ( He, X; Liu, D; Tian, H; Tian, L; Ye, Y; Zhou, F, 2023)
"Observational studies have shown that nonalcoholic fatty liver disease (NAFLD) is highly correlated with serum uric acid (SUA)."5.72Serum Uric Acid Levels and Nonalcoholic Fatty Liver Disease: A 2-Sample Bidirectional Mendelian Randomization Study. ( Cui, J; Fu, Y; Li, H; Li, S; Liu, M; Liu, Y; Tian, L; Zhang, X; Zhuo, L, 2022)
"Allopurinol treatment significantly reduced hepatic steatosis, epididymal fat, serum UA, HOMA-IR, hepatic enzyme levels, and cholesterol in the OLETF-HFrD-Allo group."5.62Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. ( Ahn, KJ; Cho, IJ; Chung, HY; Hwang, YC; Jeong, IK; Jeong, SW; Lee, SH; Lim, SJ; Moon, JY; Oh, DH; Yoo, J, 2021)
"Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD)."5.62Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study. ( Chen, S; Jiao, Y; Ma, X; Shi, H; Sun, X; Wu, S; Xing, J; Yang, R; Zhang, Q; Zhang, S, 2021)
"However, the pathogenesis of NAFLD, especially how non-alcoholic fatty liver progress to non-alcoholic steatohepatitis, is still unclear."5.56Exosomal miRNAs Profile in Children's Nonalcoholic Fatty Liver Disease and the Correlation with Transaminase and Uric Acid. ( Dong, G; Fu, J; Huang, K; Jia, J; Liang, X; Lin, H; Ni, Y; Peng, W; Wu, W; Yuan, J; Zhou, X, 2020)
"The presence or absence of NAFLD was assessed by abdominal ultrasonography."5.56Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Nonobese Postmenopausal Women: A Cross-sectional Study. ( Bao, T; Du, J; Gao, W; Gong, L; Huang, Y; Ji, G; Jiang, X; Li, Z; Tang, H; Yang, H; Ying, Z, 2020)
"The levels of SUA in subjects with NAFLD in the menstrual period, menopause transition period, and postmenopause were 268."5.51Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups. ( Ai, P; Chen, X; Chen, Y; Ding, G; Feng, X; Huang, Q; Ji, L; Li, D; Li, Y; Liu, H; Wang, X; Xu, X; Zhou, Y, 2019)
"Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis."5.51Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD). ( Aller, R; Ampuero, J; Andrade, RJ; Aspichueta, P; Buque, X; Burgos-Santamaría, D; Fernández Rodríguez, CM; Gómez-Camarero, J; Gutiérrez García, ML; Hernández-Guerra, M; Latorre, M; Martín-Mateos, RMª; Romero-Gómez, M; Rosales, JM, 2019)
"The target of theacrine's activities on NAFLD is identified as SIRT3."5.48Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. ( Gong, L; He, RR; Hong, M; Kurihara, H; Li, YF; Tian, JY; Wang, GE; Wu, YP; Yao, N; Zhai, YJ, 2018)
"Hyperuricemia is associated with metabolic syndrome (MetS), but the association is often confounded by the shared background of obesity."5.46Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia. ( Du, T; Li, M; Lin, X; Lu, H; Yu, X; Zhang, S, 2017)
"There was an obvious increase in both NAFLD prevalence (26."5.43Urine uric acid excretion is associated with nonalcoholic fatty liver disease in patients with type 2 diabetes. ( Bao, YQ; Chen, MY; Jia, WP; Li, LX; Li, TT; Wang, AP; Yu, TP; Zhao, CC; Zhu, Y, 2016)
"Furthermore, the prevalence rate of NAFLD increased progressively across the sex-specific SUA tertiles only in men (37."5.43Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients. ( Fan, N; Peng, L; Peng, Y; Wang, Y; Xia, Z; Zhang, L, 2016)
"In the present study, 841 NAFLD males (30-75 years) were recruited from a Chinese prospective cohort study (PMMJS) and followed up for five years."5.43Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males. ( Dong, C; Guo, Z; Liu, C; Qiu, J; Song, K; Wang, Y; Xu, Y; Zhang, B; Zhou, H; Zhou, Z, 2016)
"The prevalence rates of NAFLD were 71."5.43Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults. ( Chen, N; He, CM; Li, X; Li, Z; Liu, CQ; Liu, S; Liu, Y; Shi, X; Wang, D; Yan, B; Yang, S; Zeng, X, 2016)
"The prevalence of NAFLD was higher in participants with higher SUA levels (10."5.42Association between serum uric acid and nonalcoholic fatty liver disease in the US population. ( Bonekamp, S; Clark, JM; Hernaez, R; Lazo, M; Liu, SH; Shih, MH, 2015)
"The association between sUA and NAFLD was significantly greater in females than in males."5.42Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study. ( Braddock, M; Chen, YP; Huang, WJ; Kong, FQ; Lin, L; Shi, KQ; Wu, SJ; Ye, BZ; Zheng, MH; Zheng, ZX; Zhu, GQ; Zou, H, 2015)
"The risk factors for T2DM patients with NAFLD are mainly BMI, WHR, TG, and SUA."5.42The Risk Factor Analysis for Type 2 Diabetes Mellitus Patients with Nonalcoholic Fatty Liver Disease and Positive Correlation with Serum Uric Acid. ( Li, YL; Mei, CX; Musha, H; Wang, HJ; Wulasihan, M; Xie, H; Xing, Y, 2015)
"To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of serum uric acid level with NAFLD in Uygur people, Xinjiang."5.40The prevalence of nonalcoholic fatty liver disease and relationship with serum uric acid level in Uyghur population. ( Cai, W; Song, JM; Sun, YP; Yao, H; Zhang, B; Zhang, YX, 2014)
"Hyperuricemia is a common finding in patients with NAFLD and is independently associated with early histological findings in this clinically relevant condition."5.40The relationship of serum uric acid with non-alcoholic fatty liver disease. ( Celebi, G; Dogru, T; Ercin, CN; Genc, H; Gurel, H; Kara, M; Kayadibi, H; Sertoglu, E, 2014)
"The prevalence of NAFLD among Chinese postmenopausal women with normal SUA was 32."5.40[Relationship between normal serum uric acid levels and nonalcoholic fatty liver disease in postmenopausal women]. ( Chen, Y; Liu, P; Lou, H; Ma, F; Zhu, Y, 2014)
"Nonalcoholic fatty liver disease (NAFLD) is an emerging health problem worldwide."5.39Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women. ( Moon, SS, 2013)
"Although many studies have indicated a relationship between nonalcoholic fatty liver disease (NAFLD) and hyperuricemia, a few studies specifically examining the effects of the severity of liver fat content (LFC) on serum uric acid (SUA) and the presence of hyperuricemia because of the limitation of the examination methods for NAFLD."5.20Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study. ( Gao, X; Li, Q; Li, X; Lin, H; Liu, X; Ma, H; Pan, B; Wang, D; Wu, J; Xia, M; Zhao, N, 2015)
" Weight, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) index as well as serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), insulin, total and direct bilirubin, fasting blood sugar (FBS), glycated hemoglobin (HbA1c), uric acid, albumin and lipid profile were evaluated at baseline and at the end of trial."5.16Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial. ( Beiraghdar, F; Ghamarchehreh, ME; Jalalian, HR; Panahi, Y; Sahebkar, A; Zare, R, 2012)
" Fructose overconsumption may result in insulin resistance, oxidative stress, inflammation, elevated uric acid levels, increased blood pressure, and increased triglyceride concentrations in both the blood and liver."5.12Fructose and the Liver. ( López-Sánchez, P; Muriel, P; Ramos-Tovar, E, 2021)
"Experimental and observational studies suggest a role for increased uric acid in non-alcoholic fatty liver disease (NAFLD)."4.95Serum uric acid levels in non-alcoholic steatosis patients: a meta-analysis. ( Fang, H; Geng, X; Huang, F; Liu, A, 2017)
"Uric acid is the end product of dietary or endogenous purines degradation, and hyperuricemia is one of the most common metabolic disorders."4.93Hyperuricemia and nonalcoholic fatty liver disease: from bedside to bench and back. ( Xu, C, 2016)
"Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease."4.93Uric acid in metabolic syndrome: From an innocent bystander to a central player. ( Jensen, T; Johnson, RJ; Kanbay, M; Lanaspa, MA; Le, M; Nakagawa, T; Rivard, C; Roncal-Jimenez, C; Solak, Y, 2016)
"An excess circulating uric acid level, even within the normal range, is always comorbid with metabolic syndrome (MS), several of its components, and nonalcoholic fatty liver disease (NAFLD), which was regarded as hepatic manifestation of MS; however, these associations remain controversial."4.91Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-Analysis of Prospective Studies. ( Li, X; Sun, L; Yang, Z; Yu, C; Yuan, H; Zhang, Z; Zhao, C; Zhu, X, 2015)
"Emerging evidence has shown that serum uric acid (SUA) elevation might cause metabolic derangements, including metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD); however, magnitude of the risk has not been quantified."4.91Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: A Meta-analysis of Prospective Studies. ( Liu, Z; Que, S; Zheng, S; Zhou, L, 2015)
"Both elevated levels of uric acid and non-alcoholic fatty liver disease (NAFLD) have been associated with increased vascular risk."4.87Hyperuricaemia and non-alcoholic fatty liver disease (NAFLD): a relationship with implications for vascular risk? ( Athyros, VG; Karagiannis, A; Katsiki, N; Mikhailidis, DP, 2011)
"The association between serum uric acid (SUA) and mortality from cardiovascular diseases (CVDs) in nonalcoholic fatty liver disease (NAFLD) participants remains uncertain."4.31Association of serum uric acid with all-cause and cardiovascular mortality among adults with nonalcoholic fatty liver disease. ( He, P; Li, H; Liu, C; Liu, M; Qin, X; Wu, Q; Yang, S; Ye, Z; Zhang, Y; Zhang, Z; Zhou, C, 2023)
"Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that is related to high serum uric acid; however, the association between the frequency of gout flares and NAFLD risk remains unclear."4.31The risk of nonalcoholic fatty liver disease in gout patients with frequent flares: a retrospective cohort study. ( Chen, Y; Chi, J; Dong, B; Liu, C; Si, K; Wang, Y; Xu, L, 2023)
" In the stratified analysis by uric acid levels, the prevalence of NAFLD was significantly higher in participants with MHO, MUNW, and MUO in the hyperuricemia group than those in the normal uric acid group, and the interaction effect of metabolic phenotypes and uric acid on NAFLD was statistical significant (P < 0."4.31Hyperuricemia as an effect modifier of the association between metabolic phenotypes and nonalcoholic fatty liver disease in Chinese population. ( Li, X; Miao, Y; Zhang, Q; Zhang, Y; Zheng, J, 2023)
" We investigated whether uric acid (UA) and the macrophage marker soluble form of cysteine scavenger receptor CD163 (sCD163) can be used as biomarkers for deteriorated metabolism or pediatric MAFLD in children with overweight or obesity."4.31Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity. ( Dalstrup Jakobsen, D; Kristensen, NM; Meldgaard Bruun, J; Orry, S, 2023)
"Overall, the XO inhibitor febuxostat exerted protective effects against NASH and atherosclerosis in SHRSP5/Dmcr rats."4.31Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats. ( Fujii, M; Fukuoka, T; Hirohata, S; Honma, K; Kakimoto, M; Kirihara, S; Kitamori, K; Nakayama, H; Ran, S; Sato, I; Watanabe, S; Yamamoto, S, 2023)
"To study the associations of non-alcoholic fatty liver disease (NAFLD), chronic kidney disease (CKD), and serum uric acid (SUA) in patients with post-myocardial infarction (MI) patients, and the relationship of SUA with 12-year mortality risk."4.31Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction. ( Boersma, E; Geleijnse, JM; Heerkens, L; Kardys, I; van Westing, AC; Voortman, T, 2023)
"Non-alcoholic fatty liver disease (NAFLD) and serum uric acid (SUA) levels are risk factors for developing cardiovascular disease (CVD)."4.12The Association between Serum Uric Acid Levels and 10-Year Cardiovascular Disease Risk in Non-Alcoholic Fatty Liver Disease Patients. ( Hwang, J; Kang, K; Kim, K; Lee, JM; Sheol, H; Shin, J; Sim, Y; Yang, T, 2022)
"Increasing evidence has supported that serum uric acid (SUA), alanine aminotransferase (ALT) and waist circumference (WC) are associated with the occurrence of non-alcoholic fatty liver disease (NAFLD)."4.12A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study. ( Chen, Y; Ding, Y; Fan, H; Tang, Z; Wang, H; Wang, J; Wang, M; Zhang, L; Zhang, R; Zhang, W, 2022)
" Hyperuricemia was diagnosed as fasting serum uric acid > 420 µmol/L in men and women."4.12Association between circulating cystatin C and hyperuricemia: a cross-sectional study. ( Chen, Y; Guo, Y; Huang, H; Shen, C; Xu, C, 2022)
"Serum uric acid (SUA) and heavy metals are closely related to non-alcoholic fatty liver disease (NAFLD)."4.12Conjunctional Relationship between Serum Uric Acid and Serum Nickel with Non-Alcoholic Fatty Liver Disease in Men: A Cross-Sectional Study. ( Jiang, J; Liu, C; Liu, W; Wang, Y; Wu, W; Yang, Z; Zhang, G, 2022)
"The association between the serum uric acid (sUA) to creatinine ratio (sUA/Cr) and non-alcoholic fatty liver disease (NAFLD) has not been sufficiently clarified."4.12Serum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States. ( Chen, X; Qian, G; Shi, G; Wang, L; Wang, R; Xue, F; Yang, N, 2022)
" Additionally, anthropometric parameters (height, weight, BMI, waist circumference, hip circumference) such as lab data including lipid profile (triglycerides, HDL, LDL), liver function parameters (ALT, AST), uric acid, glucose metabolism (fasting insulin and glucagon, HbA1c, glucose 120 min) and indices evaluating insulin resistance (HIRI, SPISE, HOMA-IR, WBISI) were measured."4.12Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease. ( Ahlström, H; Bergsten, P; Forslund, A; Kullberg, J; Manell, H; Mangge, H; Maruszczak, K; Mörwald, K; Pixner, T; Radzikowski, K; Schütz, S; Weghuber, D, 2022)
"The Uric acid to HDL cholesterol ratio of the Non-alcoholic fatty liver disease (13±5%) group was significantly higher compared to the Uric acid to HDL cholesterol ratio of the control (10±4%) group (p<0."4.02The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study. ( Aktas, G; Bilgin, S; Demirkol, ME; Duman, TT; Kahveci, G; Kosekli, MA; Kurtkulagii, O; Tel, BMA, 2021)
"d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver."3.96The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. ( Amézqueta, S; Atienza, L; Casas, J; Hereu, M; Medina, I; Miralles-Pérez, B; Muñoz, S; Ramos-Romero, S; Romeu, M; Torres, JL, 2020)
"It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of non-alcoholic fatty liver disease (NAFLD)."3.96Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study. ( Guo, X; Kang, X; Li, H; Ma, Z; Tao, L; Xu, C; Yang, X; Zhang, S; Zheng, D, 2020)
" After adjustment for age, sex, body mass index (BMI), alanine aminotransferase (ALT), uric acid (UA), total bilirubin (TB), fasting plasma glucose (FPG) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), the OR for tertile 3 (OR = 1."3.96Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study. ( Lu, G; Miao, L; Xu, C; Xue, Z; Yang, S; Ye, M; Zhong, J; Zhou, X, 2020)
"To investigate the diagnostic role of combined salivary uric acid (UA), glucose and insulin levels to screen noninvasively for metabolic syndrome (MetS) and nonalcoholic fatty liver disease."3.91Salivary markers of hepato-metabolic comorbidities in pediatric obesity. ( Belmonte, F; Bisogno, A; Cavallo, P; Guercio Nuzio, S; Landolfi, A; Lausi, O; Marciano, F; Pierri, L; Troisi, J; Vajro, P, 2019)
" The fast food-type pattern was further associated with higher levels of C-reactive protein and uric acid and the unsaturated fatty acid pattern with reduced levels of insulin and homeostatic model assessment of insulin resistance (P < 0."3.91Dietary patterns and non-alcoholic fatty liver disease in a Greek case-control study. ( Borsa, D; Dedoussis, GV; Dimitriou, M; Kalafati, IP; Kokkinos, A; Revenas, K, 2019)
" Classical (fasting glucose, TGL, HDL, blood pressure) and non classical (insulin resistance [HOMA-IR], creatinine, AST, ALT, uric acid, fibrinogen, liver US and 24h BP profile) risk factors were compared between groups with and without MS."3.88Shall we diagnose metabolic syndrome in adolescents? ( Janus, D; Ruszała, A; Starzyk, JB; Szczudlik, E; Sztefko, K; Wójcik, M, 2018)
"Epidemiological evidence suggests sex difference in serum uric acid (SUA) and alanine aminotransferase (ALT) might be a potential explanation for the gender difference in prevalence of non-alcoholic fatty liver disease (NAFLD)."3.88Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study. ( Li, D; Li, X; Liu, F; Ma, Q; Song, X; Wang, X; Yang, H; Zhang, X, 2018)
"Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects."3.85Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults. ( Chen, H; Gong, L; Luo, R; Peng, B; Ren, W; Wang, Y; Zheng, X, 2017)
"Serum uric acid (SUA) is a new therapeutic target for non-alcoholic fatty liver disease (NAFLD)."3.85A rapid and high-throughput method for the determination of serum uric acid based on microarray technology and nanomaterial. ( Bai, Y; Feng, F; Li, X; Zhang, Z, 2017)
"Nonalcoholic fatty liver disease patients had significantly lower IGF-1 standard deviation score (IGF-1 SDS) and higher body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and uric acid levels than the control group."3.85Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents. ( Cheng, X; Hu, Y; Li, G; Liang, S; Song, R, 2017)
"Subject age and measurements of liver enzymes, γ- glutamyl transpeptidase (γGT), uric acid, high-density lipoprotein cholesterol, and insulin resistance were significantly different between the non-NAFLD group and NAFLD group."3.83Insulin resistance, body composition, and fat distribution in obese children with nonalcoholic fatty liver disease. ( Chang, EJ; Yang, HR, 2016)
"The causal relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) has not yet been clarified."3.81Serum uric acid and non-alcoholic fatty liver disease in non-hypertensive Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study. ( Dou, LJ; Gong, Y; Liang, J; Liu, XK; Pei, Y; Qi, L; Qiu, QQ; Yang, MQ; Zou, CY, 2015)
"Elevated serum uric acid levels reflect and also cause both oxidative stress and insulin resistance and are frequently observed in patients with the metabolic syndrome."3.81The association between the serum levels of uric acid and alanine aminotransferase in a population-based cohort. ( Ben-Assuli, O; Chodick, G; Goldstein, A; Magid, A; Rabinowich, L; Shalev, V; Shibolet, O; Zelber-Sagi, S, 2015)
" There were positive correlations between NAFLD and insulin resistance index (HOMA-IR), free fatty acids (FFA), tumor necrosis factor-α (TNF-α), omentin-1, visceral fat area, homocysteine (HCY), and serum uric acid (UA)."3.81Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus. ( Di, F; Gao, L; Jia, G; Li, N; Li, Q; Shao, J; Wang, L; Wang, Q, 2015)
"Serum uric acid levels have been reported to be associated with non-alcoholic fatty liver disease (NAFLD)."3.80Relationship between serum uric acid levels and hepatic steatosis in non-obese postmenopausal women. ( Chen, Y; Liu, PJ; Lou, HP; Ma, F; Zhu, YN, 2014)
"Serum uric acid levels are significantly associated with nonalcoholic fatty liver disease (NAFLD)."3.80The significance of serum xanthine oxidoreductase in patients with nonalcoholic fatty liver disease. ( Chen, Y; Xu, C; Zhang, J; Zhao, Y, 2014)
" Thus, application of ursodeoxycholic acid, rosuvastatin and allopurinol in these study patients with NAFLD dosages in combination with hyperuricemia improves the clinical symptoms and normalization of biochemical parameters and normalizes the spectrum of biliary acids."3.80[CORRECTION OF BILE FLOW CHARACTERISTICS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH HYPERURICEMIA]. ( Barabanchyk, OV; Kozak, NP; Svintsits'kyĭ, AS, 2014)
"Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance."3.79Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. ( Gao, Y; Hu, Y; Huang, Z; Li, L; Li, Z; Liang, Z; Liao, M; Lu, Z; Mo, Z; Peng, T; Qin, X; Shi, D; Sun, Y; Tan, A; Wang, M; Wu, C; Xie, Y; Yang, X; Zhang, H; Zhang, S; Zhang, Y, 2013)
"The aim of this study was to compare serum uric acid values in two ethnically distinct Chinese populations: Uyghur, with a high prevalence of nonalcoholic fatty liver disease, and Han, with a lower prevalence."3.79Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China. ( Cai, W; Miao, L; Sun, YP; Wu, X; Yao, H; Zhang, B; Zou, Y, 2013)
"Experimental and observational studies suggest a role for uric acid in non-alcoholic fatty liver disease (NAFLD)."3.79Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. ( Chonchol, M; Jalal, DI; Johnson, RJ; McFann, K; Sirota, JC; Targher, G, 2013)
"The objective of the present study was to determine the relationship between serum uric acid (SUA) level and the presence of nonalcoholic fatty liver disease (NAFLD)."3.77The relationship between normal serum uric acid and nonalcoholic fatty liver disease. ( Ahn, HY; Hwang, IC; Suh, AR; Suh, SY, 2011)
" In this line recent studies observed an independent link between higher uric acid serum levels and clinical diagnosis of non-alcoholic fatty liver disease (NAFLD)."3.77Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease. ( Cabibi, D; Cammà, C; Craxì, A; Di Marco, V; Petta, S, 2011)
"Hepatic inflammation is prevalent in several metabolic liver diseases."2.82The contribution of sterile inflammation to the fatty liver disease and the potential therapies. ( Shaker, ME, 2022)
"Curcumin is a dietary natural product with beneficial metabolic effects relevant to the treatment of NAFLD."2.82Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial. ( Jafari, R; Kianpour, P; Mohtashami, R; Panahi, Y; Sahebkar, A; Simental-Mendía, LE, 2016)
"Atorvastatin, which has proven safe in NAFLD/NASH, reduces SUA levels, ameliorates NAFLD/NASH, prevents liver fibrosis, and above all substantially reduces CVD morbidity and mortality in comparison with those on statins but without NAFLD/NASH."2.58Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease? ( Athyros, VG; Giouleme, O; Grammatikos, N; Katsoula, A; Paschos, P; Tsimperidis, A, 2018)
"Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome; its rising prevalence parallels the rise in obesity and diabetes."2.58Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. ( Abdelmalek, MF; Diehl, AM; Green, M; Jensen, T; Johnson, RJ; Kang, DH; Kuwabara, M; Lanaspa, MA; Nadeau, KJ; Nakagawa, T; Roncal, C; Rosen, HR; Sanchez-Lozada, LG; Sato, Y; Sullivan, S; Tolan, DR, 2018)
"Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD)."2.55Hyperuricemia is associated with nonalcoholic fatty liver disease activity score in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis. ( Ahuja, W; Jaruvongvanich, V; Ungprasert, P; Wijarnpreecha, K; Wirunsawanya, K, 2017)
"non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders."2.55Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis. ( Darmawan, G; Hamijoyo, L; Hasan, I, 2017)
"The risk of NAFLD in subjects with hyperuricaemia was significantly higher than subjects with normal uric acid level with the pooled odds ratio (OR) of 1."2.55Hyperuricaemia and risk of nonalcoholic fatty liver disease: A meta-analysis. ( Cheungpasitporn, W; Lekuthai, N; Panjawatanan, P; Thongprayoon, C; Ungprasert, P; Wijarnpreecha, K, 2017)
"Uric acid is a natural antioxidant."2.55Hyperuricemia is not associated with severity of liver fibrosis in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis. ( Ahuja, W; Jaruvongvanich, V; Ungprasert, P; Wijarnpreecha, K, 2017)
"Nonalcoholic fatty liver disease (NAFLD) is a major, worldwide public health problem."2.53Serum uric acid: a new therapeutic target for nonalcoholic fatty liver disease. ( Braddock, M; Liu, WY; Lu, QD; Shi, KQ; Song, D; Sun, DQ; Wu, SJ; Zheng, MH; Zhu, GQ, 2016)
"Hyperuricemia is associated with an increased risk of NAFLD in Asian populations."2.53Hyperuricemia and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis. ( Gong, S; Song, J; Wang, L; Wang, Y; Zhang, S, 2016)
"The risk of NAFLD seemed more pronounced among women (OR 1."2.53High serum uric acid and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis. ( Fan, Y; Wei, F; Zhou, Y, 2016)
"Nonalcoholic fatty liver disease (NAFLD), tightly linked to the metabolic syndrome (MS), has emerged as a leading cause of chronic liver disease worldwide."2.53Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD. ( Fargion, S; Lombardi, R; Pisano, G, 2016)
"NAFLD was assessed using the Fibrosis-4 (Fib-4) index."1.91Improvement in hepatic fibrosis estimated by Fibrosis-4 index in pegloticase treated chronic refractory gout patients. ( Lipsky, PE; Rustgi, VK; Schlesinger, N; Yeo, AE, 2023)
"We modeled the relationship between NAFLD and relevant demographic, anthropometric, and biochemical variables."1.91The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population. ( Pirola, CJ; Sookoian, S, 2023)
"Abdominal obesity is the strongest risk factor for type 2 diabetes in lean nonalcoholic fatty liver disease."1.91Association between the lean nonalcoholic fatty liver disease and risk of incident type 2 diabetes in a healthy population of Northwest China: a retrospective cohort study with a 2-year follow-up period. ( Chang, M; Li, D; Li, N; Tan, H; Wu, S; Xang, W; Xie, C; Zhang, MY, 2023)
"A total of 175 adult patients with NAFLD diagnosed by abdominal ultrasonography were included in this study."1.91Association of neck circumference-related indices with metabolic, atherogenic and liver function biomarkers in patients with non-alcoholic fatty liver disease: a cross-sectional study. ( Arefhosseini, S; Arefhosseini, SR; Ebrahimi-Mameghani, M; Tavakkoli, S; Tutunchi, H, 2023)
"The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide."1.91Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population. ( He, X; Liu, D; Tian, H; Tian, L; Ye, Y; Zhou, F, 2023)
"In this study, type 2 diabetes (T2D), sex, and menopausal status were combined to refine the stratification of obesity regarding the risk of advanced SLD and gain further insight into disease physiopathology."1.91Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study. ( Baud, G; Bauvin, P; Caiazzo, R; Chatelain, E; Chetboun, M; Gnemmi, V; Lasailly, G; Lefebvre, P; Legendre, B; Leteurtre, E; Marciniak, C; Marot, G; Mathurin, P; Oukhouya-Daoud, N; Pattou, F; Raverdy, V; Staels, B; Vandel, J; Vantyghem, MC; Verkindt, H, 2023)
"Observational studies have shown that nonalcoholic fatty liver disease (NAFLD) is highly correlated with serum uric acid (SUA)."1.72Serum Uric Acid Levels and Nonalcoholic Fatty Liver Disease: A 2-Sample Bidirectional Mendelian Randomization Study. ( Cui, J; Fu, Y; Li, H; Li, S; Liu, M; Liu, Y; Tian, L; Zhang, X; Zhuo, L, 2022)
"Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and risk factors."1.72The Negative Association Between NAFLD Severity and CKD in a Non-Diabetic Gouty Population. ( Chen, Y; Chi, J; Huang, Y; Lv, W; Wang, Y; Zhou, Y, 2022)
"Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease."1.72Sex-specific metabolic risk factors and their trajectories towards the non-alcoholic fatty liver disease incidence. ( Guo, X; Halengbieke, A; Han, Y; Kong, L; Li, Q; Ni, X; Tao, L; Tong, C; Wu, Z; Yang, X; Zhang, S; Zheng, D, 2022)
"The lean/normal-weight NAFLD−non-MAFLD patients with higher SUA levels are still at high risk of severe steatosis."1.72The Additive Values of the Classification of Higher Serum Uric Acid Levels as a Diagnostic Criteria for Metabolic-Associated Fatty Liver Disease. ( Chen, Y; Feng, S; He, J; Sun, Y; Ye, J; Zhong, B, 2022)
"Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are two pathologies that intersect each other."1.72Non-alcoholic fatty liver disease: correlation with hyperuricemia in a European Mediterranean population. ( Catanzaro, R; He, F; Marotta, F; Sciuto, M; Singh, B, 2022)
"Independent risk factors of NAFLD were identified by multivariate logistic regression analysis."1.62A nomogram for discrimination of non-alcoholic fatty liver disease in patients with chronic hepatitis B. ( Cao, D; Chen, Y; Han, Q; Li, C; Li, N; Liu, Z; Wang, X; Zhang, P, 2021)
"The odds of NAFLD were increasingly higher from the second to the fourth quartile of SUA as compared to the lowest quartile."1.62Serum uric acid is positively associated with the prevalence of nonalcoholic fatty liver in non-obese type 2 diabetes patients in a Chinese population. ( Cui, Y; Hu, W; Liu, J; Shi, H; Song, L; Zhao, Q, 2021)
"Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with few therapeutic options available currently."1.62Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota. ( Chen, L; Han, R; Hong, Y; Li, B; Li, H; Ma, J; Qiu, H; Sheng, L; Wu, G; Zheng, N; Zhong, J, 2021)
"The diagnosis of NAFLD was according to the clinical diagnosis of the guidelines."1.62Study on the independent effect of thyroid hormone based on uric acid level on NAFLD. ( Chao, G; Chen, L, 2021)
"Allopurinol treatment significantly reduced hepatic steatosis, epididymal fat, serum UA, HOMA-IR, hepatic enzyme levels, and cholesterol in the OLETF-HFrD-Allo group."1.62Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. ( Ahn, KJ; Cho, IJ; Chung, HY; Hwang, YC; Jeong, IK; Jeong, SW; Lee, SH; Lim, SJ; Moon, JY; Oh, DH; Yoo, J, 2021)
"Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD)."1.62Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study. ( Chen, S; Jiao, Y; Ma, X; Shi, H; Sun, X; Wu, S; Xing, J; Yang, R; Zhang, Q; Zhang, S, 2021)
"Nonalcoholic fatty liver disease (NAFLD) commonly occurs in patients with type 2 diabetes mellitus (T2DM)."1.56Increased plasma osteopontin levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. ( Chen, W; He, M; Li, S; Liu, D; Long, M; Peng, J; Wang, C; Yang, G; Zhang, L, 2020)
"Background The prevalence of childhood obesity and its related comorbidities in Malaysia are alarming."1.56Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity. ( Anuar Zaini, A; Jalaludin, MY; Mohamed, RZ, 2020)
"Hyperuricemia is a major risk for non-alcoholic fatty liver disease."1.56Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis. ( Chen, D; Chen, S; Wang, J; Wang, X; Xu, C; Yang, H, 2020)
"However, the pathogenesis of NAFLD, especially how non-alcoholic fatty liver progress to non-alcoholic steatohepatitis, is still unclear."1.56Exosomal miRNAs Profile in Children's Nonalcoholic Fatty Liver Disease and the Correlation with Transaminase and Uric Acid. ( Dong, G; Fu, J; Huang, K; Jia, J; Liang, X; Lin, H; Ni, Y; Peng, W; Wu, W; Yuan, J; Zhou, X, 2020)
"Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity."1.56Associations between obesity and metabolic health with nonalcoholic fatty liver disease in elderly Chinese. ( Chen, G; Chen, XH; He, H; Kuang, Y; Lin, BY; Wu, LM; Zheng, SS, 2020)
"The presence or absence of NAFLD was assessed by abdominal ultrasonography."1.56Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Nonobese Postmenopausal Women: A Cross-sectional Study. ( Bao, T; Du, J; Gao, W; Gong, L; Huang, Y; Ji, G; Jiang, X; Li, Z; Tang, H; Yang, H; Ying, Z, 2020)
"The prevalence of nonalcoholic fatty liver disease (NAFLD) in the non-obese population has increased and NAFLD is not always recognized in individuals with metabolic syndrome (MS)."1.56Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome. ( Hirao, A; Kagemoto, K; Kida, Y; Kurihara, T; Nakasono, M; Okahisa, T; Okamoto, K; Okazaki, J; Sogabe, M; Takayama, T; Takehara, M; Tanaka, H; Taniguchi, T; Tomonari, T, 2020)
"(1) In retired persons, prevalence of NAFLD was greater in females (81."1.56Correlation between income and non-alcoholic fatty liver disease in a Chinese population. ( Fan, YQ; Hao, HR; Hu, W; Liu, Z; Ni, YJ; Shao, XJ; Wang, XQ; Wen, SR; Wu, XJ; Yu, WN, 2020)
"The levels of SUA in subjects with NAFLD in the menstrual period, menopause transition period, and postmenopause were 268."1.51Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups. ( Ai, P; Chen, X; Chen, Y; Ding, G; Feng, X; Huang, Q; Ji, L; Li, D; Li, Y; Liu, H; Wang, X; Xu, X; Zhou, Y, 2019)
"We recruited 1527 adult patients with NAFLD who completed a comprehensive health checkup."1.51The severity of NAFLD is associated with the risk of urolithiasis. ( Qin, S; Wang, J; Wang, S; Wang, X; Xu, Y; Zhang, Y; Zhou, C, 2019)
"Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis."1.51Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD). ( Aller, R; Ampuero, J; Andrade, RJ; Aspichueta, P; Buque, X; Burgos-Santamaría, D; Fernández Rodríguez, CM; Gómez-Camarero, J; Gutiérrez García, ML; Hernández-Guerra, M; Latorre, M; Martín-Mateos, RMª; Romero-Gómez, M; Rosales, JM, 2019)
"Hyperuricemia is a risk factor for nonalcoholic fatty liver disease (NAFLD), however, the effect of gender on the hyperuricemia-related NAFLD development remains unclear."1.51Gender effect of hyperuricemia on the development of nonalcoholic fatty liver disease (NAFLD): A clinical analysis and mechanistic study. ( Bao, J; Cai, Z; Fu, X; Li, Y; Li, Z; Miao, L; Qiao, L; Xu, K; Zhao, X, 2019)
"Elderly obese patients with NAFLD are at a higher risk of CKD."1.51Association of obesity with chronic kidney disease in elderly patients with nonalcoholic fatty liver disease. ( Bian, J; Chen, F; Jin, D; Li, H; Luo, K; Wang, J; Wang, Q, 2019)
"A cohort of 6310 initially NAFLD-free participants was enrolled in this prospective study."1.48Risk for the development of non-alcoholic fatty liver disease: A prospective study. ( Chen, S; Li, Y; Ma, L; Miao, M; Wang, J; Xu, C; Xu, L; Yu, C, 2018)
"NAFLD was determined by hepatic ultrasonography, then its clinical features were analyzed and its associated risk factors evaluated."1.48Prevalence and clinical characteristics of non-alcoholic fatty liver disease in newly diagnosed patients with ketosis-onset diabetes. ( Chen, MY; Jia, WP; Li, LX; Li, TT; Lu, JX; Tang, ZH; Wang, AP; Zhao, CC, 2018)
"Although MS and NAFLD were more prevalent in adolescents, young children also demonstrated MS and NAFLD as obesity-related complications."1.48Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity. ( Cho, J; Kim, JY; Yang, HR, 2018)
"The target of theacrine's activities on NAFLD is identified as SIRT3."1.48Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. ( Gong, L; He, RR; Hong, M; Kurihara, H; Li, YF; Tian, JY; Wang, GE; Wu, YP; Yao, N; Zhai, YJ, 2018)
"Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors."1.48Nonalcoholic Fatty Liver Disease Is Associated with Increased Atrial Fibrillation Risk in an Elderly Chinese Population: A Cross-Sectional Study. ( Li, P; Liu, Y; Miao, M; Pan, Y; Xu, C; Xu, L; Zhang, Y; Zhu, Z, 2018)
"Hyperuricemia is associated with metabolic syndrome (MetS), but the association is often confounded by the shared background of obesity."1.46Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia. ( Du, T; Li, M; Lin, X; Lu, H; Yu, X; Zhang, S, 2017)
"There was a significant association in NAFLD found in males, compared with females (Wald = 118."1.46Gender difference on the relationship between hyperuricemia and nonalcoholic fatty liver disease among Chinese: An observational study. ( Shen, XM; Shu, L; Yu, XL; Zhang, XY; Zheng, PF, 2017)
"Obese children with NAFLD were studied (n=271)."1.46Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. ( Alisi, A; Byrne, CD; Crudele, A; De Vito, R; Mosca, A; Nobili, V; Scorletti, E; Villani, A, 2017)
"123 participants who had NAFLD at baseline lost NAFLD during the 8-year follow-up period."1.43Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study. ( Chen, XH; Li, YL; Lu, ZY; Shao, Z; Wulasihan, M, 2016)
"There was an obvious increase in both NAFLD prevalence (26."1.43Urine uric acid excretion is associated with nonalcoholic fatty liver disease in patients with type 2 diabetes. ( Bao, YQ; Chen, MY; Jia, WP; Li, LX; Li, TT; Wang, AP; Yu, TP; Zhao, CC; Zhu, Y, 2016)
"Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and correlated with obesity."1.43Risk factor compositions of nonalcoholic fatty liver disease change with body mass index in males and females. ( Guo, J; Lu, J; Wang, L, 2016)
"Furthermore, the prevalence rate of NAFLD increased progressively across the sex-specific SUA tertiles only in men (37."1.43Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients. ( Fan, N; Peng, L; Peng, Y; Wang, Y; Xia, Z; Zhang, L, 2016)
"In the present study, 841 NAFLD males (30-75 years) were recruited from a Chinese prospective cohort study (PMMJS) and followed up for five years."1.43Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males. ( Dong, C; Guo, Z; Liu, C; Qiu, J; Song, K; Wang, Y; Xu, Y; Zhang, B; Zhou, H; Zhou, Z, 2016)
"The prevalence rates of NAFLD were 71."1.43Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults. ( Chen, N; He, CM; Li, X; Li, Z; Liu, CQ; Liu, S; Liu, Y; Shi, X; Wang, D; Yan, B; Yang, S; Zeng, X, 2016)
"Children with histologically proven NAFLD, and obese and lean controls received oral fructose (1 g kg(-1) ideal body weight)."1.42Oral fructose absorption in obese children with non-alcoholic fatty liver disease. ( Johnson, RJ; Le, MT; Love-Osborne, K; Pan, Z; Rivard, C; Robbins, K; Sokol, RJ; Sullivan, JS; Sundaram, SS, 2015)
"The prevalence of NAFLD in light drinkers was significantly lower than in non-drinkers, and supporting previous reports studying the general population, LAC is one of the significant predictors of a decreased prevalence of NAFLD in men with MS."1.42Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome. ( Nakasono, M; Okahisa, T; Sogabe, M; Takayama, T; Tanaka, H; Tanaka, T; Taniguchi, T; Tomonari, T, 2015)
"Hyperuricemia is a common feature of patients with non-alcoholic fatty liver disease (NAFLD)."1.42Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds. ( Dooley, S; Li, Y; Miao, M; Sun, Y; Wan, X; Weng, H; Xu, C; Xu, G; Xu, L; Yan, M; Yu, C, 2015)
"The prevalence of NAFLD was higher in participants with higher SUA levels (10."1.42Association between serum uric acid and nonalcoholic fatty liver disease in the US population. ( Bonekamp, S; Clark, JM; Hernaez, R; Lazo, M; Liu, SH; Shih, MH, 2015)
"The association between sUA and NAFLD was significantly greater in females than in males."1.42Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study. ( Braddock, M; Chen, YP; Huang, WJ; Kong, FQ; Lin, L; Shi, KQ; Wu, SJ; Ye, BZ; Zheng, MH; Zheng, ZX; Zhu, GQ; Zou, H, 2015)
"NAFLD is closely correlated with baPWV, particularly in females."1.42Correlation between non-alcoholic fatty liver with metabolic risk factors and brachial-ankle pulse wave velocity. ( Chen, JH; Chen, LY; Dai, HL; Fang, LZ; Lu, CR; Qiao, QH; Zhu, WH, 2015)
"Whether nonalcoholic fatty liver disease (NAFLD) is related to vitamin D and bone health in obese children is unknown."1.42Vitamin D Status and Bone Mineral Density in Obese Children with Nonalcoholic Fatty Liver Disease. ( Chang, EJ; Yang, HR; Yi, DY, 2015)
"The risk factors for T2DM patients with NAFLD are mainly BMI, WHR, TG, and SUA."1.42The Risk Factor Analysis for Type 2 Diabetes Mellitus Patients with Nonalcoholic Fatty Liver Disease and Positive Correlation with Serum Uric Acid. ( Li, YL; Mei, CX; Musha, H; Wang, HJ; Wulasihan, M; Xie, H; Xing, Y, 2015)
"To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of serum uric acid level with NAFLD in Uygur people, Xinjiang."1.40The prevalence of nonalcoholic fatty liver disease and relationship with serum uric acid level in Uyghur population. ( Cai, W; Song, JM; Sun, YP; Yao, H; Zhang, B; Zhang, YX, 2014)
"Hyperuricemia is a common finding in patients with NAFLD and is independently associated with early histological findings in this clinically relevant condition."1.40The relationship of serum uric acid with non-alcoholic fatty liver disease. ( Celebi, G; Dogru, T; Ercin, CN; Genc, H; Gurel, H; Kara, M; Kayadibi, H; Sertoglu, E, 2014)
"The prevalence of NAFLD among Chinese postmenopausal women with normal SUA was 32."1.40[Relationship between normal serum uric acid levels and nonalcoholic fatty liver disease in postmenopausal women]. ( Chen, Y; Liu, P; Lou, H; Ma, F; Zhu, Y, 2014)
"Nonalcoholic fatty liver disease (NAFLD) affects 9."1.40Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. ( Behling, C; Donithan, M; Hallinan, EK; Newton, KP; Schwimmer, JB; Tonascia, J; Xanthakos, SA; Zepeda, A, 2014)
"Nonalcoholic fatty liver disease (NAFLD) is an emerging health problem worldwide."1.39Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women. ( Moon, SS, 2013)
"Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children in the United States."1.38Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD. ( Belt, P; Colvin, R; Lavine, JE; Molleston, JP; Murray, KF; Rosenthal, P; Schwimmer, JB; Tonascia, J; Unalp, A; Vos, MB, 2012)
"Patients with NAFLD had significantly lower levels of serum-free thyroxine (FT4) than controls (11·12 ± 1·43 vs 11·58 ± 1·47 pmol/l; P < 0·001)."1.37Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese. ( Li, Y; Miao, M; Xu, C; Xu, L; Yu, C, 2011)
" In addition, there was a dose-response relationship between SU and NAFLD in subjects with and without gout."1.36Gout and risk of non-alcoholic fatty liver disease. ( Chang, HC; Chen, HW; Chiu, CT; Hwang, JS; Ko, YS; Kuo, CF; Luo, SF; See, LC; Tseng, WY; Yu, KH, 2010)

Research

Studies (171)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's104 (60.82)24.3611
2020's67 (39.18)2.80

Authors

AuthorsStudies
Kosekli, MA1
Kurtkulagii, O1
Kahveci, G1
Duman, TT1
Tel, BMA1
Bilgin, S1
Demirkol, ME1
Aktas, G1
Yang, Y3
Qu, Y2
Lv, X1
Zhao, R1
Yu, J1
Hu, S1
Kang, J2
Zhang, Y11
Gong, Y2
Cui, T1
Zhang, X10
Yan, Y1
Kim, K1
Kang, K1
Sheol, H1
Shin, J1
Sim, Y1
Yang, T3
Hwang, J1
Lee, JM1
Wang, M3
Zhang, R2
Zhang, L6
Ding, Y2
Tang, Z1
Fan, H1
Wang, H3
Zhang, W1
Chen, Y16
Wang, J12
Shaker, ME1
Schlesinger, N1
Rustgi, VK1
Yeo, AE1
Lipsky, PE1
Guo, Y1
Huang, H2
Shen, C1
Xu, C14
Li, S3
Fu, Y2
Liu, Y8
Li, H9
Tian, L2
Zhuo, L1
Liu, M2
Cui, J2
Huang, Y4
Zhou, Y3
Wang, Y11
Chi, J2
Lv, W1
Zhu, W1
Liang, A1
Shi, P1
Yuan, S1
Zhu, Y4
Fu, J2
Zheng, T1
Wen, Z2
Wu, X3
Sookoian, S1
Pirola, CJ1
Liu, C8
Liu, W1
Zhang, G1
Jiang, J2
Yang, Z2
Wu, W3
Wang, R1
Xue, F2
Wang, L5
Shi, G1
Qian, G1
Yang, N2
Chen, X4
Tong, C1
Li, Q5
Kong, L1
Ni, X1
Halengbieke, A1
Zhang, S8
Wu, Z1
Tao, L3
Han, Y2
Zheng, D3
Guo, X4
Yang, X7
Yang, S4
Ye, Z1
Wu, Q2
Zhou, C2
Zhang, Z3
He, P1
Qin, X2
He, J1
Ye, J2
Sun, Y4
Feng, S1
Zhong, B1
Maruszczak, K1
Radzikowski, K1
Schütz, S1
Mangge, H1
Bergsten, P1
Forslund, A1
Manell, H1
Pixner, T1
Ahlström, H1
Kullberg, J1
Mörwald, K1
Weghuber, D1
Hamed, MA1
Akhigbe, RE1
Aremu, AO1
Odetayo, AF1
Sun, D4
Tang, C3
Zhao, Q6
Qin, Y3
Zhang, J8
Ferro, Y1
Maurotti, S1
Mazza, E1
Pujia, R1
Sciacqua, A1
Musolino, V1
Mollace, V1
Pujia, A1
Montalcini, T1
Theofilis, P1
Vordoni, A1
Tsimihodimos, V1
Kalaitzidis, RG1
Si, K1
Xu, L6
Dong, B1
Zheng, J2
Li, X17
Miao, Y1
Zhang, Q4
Chen, S6
Wang, X12
Zhai, H1
Fan, WH1
Zhu, T1
Xu, G2
Liao, W2
Liang, XS1
Li, CZ1
Hwang, SM1
Cho, KY1
Orry, S1
Dalstrup Jakobsen, D1
Kristensen, NM1
Meldgaard Bruun, J1
Yu, C5
Zhou, X5
Wang, T2
Zhu, L1
Zhou, W1
Bao, H1
Cheng, X2
Feng, Y1
Zheng, S2
Liu, L4
Kakimoto, M1
Fujii, M1
Sato, I1
Honma, K1
Nakayama, H1
Kirihara, S1
Fukuoka, T1
Ran, S1
Hirohata, S1
Kitamori, K1
Yamamoto, S1
Watanabe, S1
Li, N4
Xang, W1
Wu, S2
Li, D5
Chang, M1
Xie, C1
Zhang, MY1
Tan, H2
Choi, J1
Joe, H1
Oh, JE1
Cho, YJ1
Shin, HS1
Heo, NH1
Wang, YY1
Chen, B2
Wang, N1
Zhang, TJ1
Jiang, YG1
Wu, YL1
He, N1
Zhao, GM1
Liu, X3
Shi, A1
Deng, J2
Ma, J2
Yang, L1
Tantai, X1
Wang, Q6
Chang, D2
Lu, X2
Shi, H3
Wang, Z2
Niu, H1
Deng, Q1
Xia, S1
Arefhosseini, S1
Tutunchi, H1
Tavakkoli, S1
Arefhosseini, SR1
Ebrahimi-Mameghani, M1
Tao, M1
Liu, J2
He, M2
Chen, W4
Wang, C5
Heerkens, L1
van Westing, AC1
Voortman, T1
Kardys, I1
Boersma, E1
Geleijnse, JM1
Zhou, F1
He, X2
Liu, D2
Ye, Y1
Tian, H1
Raverdy, V1
Chatelain, E1
Lasailly, G1
Caiazzo, R1
Vandel, J1
Verkindt, H1
Marciniak, C1
Legendre, B1
Bauvin, P1
Oukhouya-Daoud, N1
Baud, G1
Chetboun, M1
Vantyghem, MC1
Gnemmi, V1
Leteurtre, E1
Staels, B1
Lefebvre, P1
Mathurin, P1
Marot, G1
Pattou, F1
Abe, T1
Miyazaki, M1
Ishihara, T1
Kanezaki, S1
Notani, N1
Kataoka, M1
Tsumura, H1
Peng, J1
Long, M1
Yang, G1
Sotoudehmanesh, R1
Tahmasbi, A1
Sadeghi, A1
Hosseini, H1
Mohamadnejad, M1
Ramos-Romero, S1
Hereu, M1
Atienza, L1
Amézqueta, S1
Casas, J1
Muñoz, S1
Medina, I1
Miralles-Pérez, B1
Romeu, M1
Torres, JL1
Huang, Q1
Ai, P1
Liu, H2
Xu, X2
Ding, G1
Li, Y12
Feng, X2
Ji, L1
Mohamed, RZ1
Jalaludin, MY1
Anuar Zaini, A1
Chen, D2
Yang, H4
Cao, D1
Li, C2
Zhang, P2
Han, Q1
Liu, Z5
Huang, K1
Jia, J1
Ni, Y1
Yuan, J1
Liang, X1
Lin, H2
Peng, W1
Dong, G1
Ma, Z2
Kang, X2
Wu, LM1
He, H1
Chen, G3
Kuang, Y2
Lin, BY1
Chen, XH2
Zheng, SS1
Nakagawa, T4
Johnson, RJ6
Andres-Hernando, A2
Roncal-Jimenez, C2
Sanchez-Lozada, LG3
Tolan, DR2
Lanaspa, MA4
Brennan, P1
Clare, K1
George, J1
Dillon, JF1
Catanzaro, R1
Sciuto, M1
He, F1
Singh, B1
Marotta, F1
Bao, T1
Ying, Z1
Gong, L3
Du, J1
Ji, G1
Li, Z6
Gao, W2
Jiang, X2
Tang, H1
Lukenda Zanko, V1
Domislovic, V1
Trkulja, V1
Krznaric-Zrnic, I1
Turk-Wensveen, T1
Krznaric, Z1
Filipec Kanizaj, T1
Radic-Kristo, D1
Bilic-Zulle, L1
Orlic, L1
Dinjar-Kujundzic, P1
Poropat, G1
Stimac, D1
Hauser, G1
Mikolasevic, I1
Sogabe, M3
Okahisa, T3
Kurihara, T1
Takehara, M1
Kagemoto, K1
Okazaki, J1
Kida, Y1
Hirao, A1
Tanaka, H3
Tomonari, T3
Taniguchi, T3
Okamoto, K1
Nakasono, M3
Takayama, T3
Nguépy Keubo, FR1
Mboua, PC1
Djifack Tadongfack, T1
Fokouong Tchoffo, E1
Tasson Tatang, C1
Ide Zeuna, J1
Noupoue, EM1
Tsoplifack, CB1
Folefack, GO1
Kettani, M1
Bandelier, P1
Huo, J1
Yu, D1
Arulsamy, N1
AlAbbad, S1
Sardot, T1
Lekashvili, O1
Decato, D1
Lelj, F1
Alexander Ross, JB1
Rosenberg, E1
Nazir, H1
Muthuswamy, N1
Louis, C1
Jose, S1
Prakash, J1
Buan, MEM1
Flox, C1
Chavan, S1
Shi, X2
Kauranen, P1
Kallio, T1
Maia, G1
Tammeveski, K1
Lymperopoulos, N1
Carcadea, E1
Veziroglu, E1
Iranzo, A1
M Kannan, A1
Arunamata, A1
Tacy, TA1
Kache, S1
Mainwaring, RD1
Ma, M1
Maeda, K1
Punn, R1
Noguchi, S1
Hahn, S3
Iwasa, Y3
Ling, J2
Voccio, JP2
Kim, Y3
Song, J4
Bascuñán, J2
Chu, Y1
Tomita, M1
Cazorla, M1
Herrera, E1
Palomeque, E1
Saud, N1
Hoplock, LB1
Lobchuk, MM1
Lemoine, J1
Henson, MA1
Unsihuay, D1
Qiu, J2
Swaroop, S1
Nagornov, KO1
Kozhinov, AN1
Tsybin, YO1
Kuang, S1
Laskin, J1
Zin, NNINM1
Mohamad, MN1
Roslan, K1
Abdul Wafi, S1
Abdul Moin, NI1
Alias, A1
Zakaria, Y1
Abu-Bakar, N1
Naveed, A1
Jilani, K1
Siddique, AB1
Akbar, M1
Riaz, M1
Mushtaq, Z1
Sikandar, M1
Ilyas, S1
Bibi, I1
Asghar, A1
Rasool, G1
Irfan, M1
Li, XY1
Zhao, S1
Fan, XH1
Chen, KP1
Hua, W1
Liu, ZM1
Xue, XD1
Zhou, B1
Xing, YL1
Chen, MA1
Neradilek, MB1
Wu, XT1
Zhang, D2
Huang, W1
Cui, Y2
Yang, QQ1
Li, HW1
Zhao, XQ1
Hossein Rashidi, B1
Tarafdari, A1
Ghazimirsaeed, ST1
Shahrokh Tehraninezhad, E1
Keikha, F1
Eslami, B1
Ghazimirsaeed, SM1
Jafarabadi, M1
Silvani, Y1
Lovita, AND1
Maharani, A1
Wiyasa, IWA1
Sujuti, H1
Ratnawati, R1
Raras, TYM1
Lemin, AS1
Rahman, MM1
Pangarah, CA1
Kiyu, A1
Zeng, C2
Du, H1
Lin, D1
Jalan, D1
Rubagumya, F1
Hopman, WM1
Vanderpuye, V1
Lopes, G1
Seruga, B1
Booth, CM1
Berry, S1
Hammad, N1
Sajo, EA1
Okunade, KS1
Olorunfemi, G1
Rabiu, KA1
Anorlu, RI1
Xiang, Y1
Zhou, L3
Dong, X1
Tang, S1
Gao, XC1
Wei, CH1
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Cai, Q1
He, Y2
Tong, F1
Dong, JH1
Wu, G2
Dong, XR1
Tang, X1
Tao, F1
Xiang, W1
Zhao, Y4
Jin, L1
Tao, H1
Lei, Y1
Gan, H1
Chen, L5
Shan, A1
Zhao, H2
Wu, M2
Ma, Q2
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Carrasco Cabrera, L1
Greco, L1
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Li, XM1
Yan, HM1
Bian, H1
Chang, XX1
He, WY1
Jeekel, J1
Hofman, A1
Sirota, JC1
McFann, K1
Targher, G1
Chonchol, M1
Jalal, DI1
Ghamarchehreh, ME1
Beiraghdar, F1
Zare, R1
Jalalian, HR1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind, Randomized, Placebo-Controlled, Phase II Study to Assess the Efficacy and Safety of Pioglitazone in Patients With Nonalcoholic Steatohepatitis[NCT01068444]Phase 290 participants (Actual)Interventional2009-04-30Completed
Allopurinol Versus Febuxostat: A New Approach for Management of Hepatic Steatosis in Metabolic-Associated Fatty Liver Disease[NCT05474560]Phase 490 participants (Actual)Interventional2022-01-01Completed
The Effect of Dietary Fructose on Gut Microbiota and Hepatosteatosis in Healthy Men[NCT04898621]58 participants (Actual)Interventional2021-06-01Completed
Genetic-specific Effects of Fructose on Liver Lipogenesis[NCT03783195]15 participants (Actual)Interventional2019-01-25Completed
A Randomized, Single-blind, Placebo-controlled Study to Evaluate the Effects of a Turmeric and Black Cumin Seed Formulation on Cholesterol Levels Among Generally Healthy Participants[NCT03175757]33 participants (Actual)Interventional2017-05-12Completed
Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept[NCT04012294]Phase 3200 participants (Anticipated)Interventional2019-08-30Recruiting
Effects of 4-month Therapy of Levothyroxine on Non-Alcoholic Fatty Liver Disease (NAFLD) and Diabetes Control in Diabetic Patients[NCT03281083]Phase 229 participants (Actual)Interventional2014-03-28Terminated (stopped due to Difficult recruitment and end of funding.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

27 reviews available for uric acid and Fatty Liver, Nonalcoholic

ArticleYear
The contribution of sterile inflammation to the fatty liver disease and the potential therapies.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 148

    Topics: Adenosine Monophosphate; Alarmins; Caspase 1; Guanosine Monophosphate; Humans; Inflammation; Inflamm

2022
Fructose Production and Metabolism in the Kidney.
    Journal of the American Society of Nephrology : JASN, 2020, Volume: 31, Issue:5

    Topics: Animals; Cardiomegaly; Diabetic Nephropathies; Dietary Sugars; Energy Metabolism; Fatty Acids; Fruct

2020
Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis: An opinion review.
    World journal of gastroenterology, 2020, Apr-21, Volume: 26, Issue:15

    Topics: Biomarkers; Humans; Hyperuricemia; Liver; Non-alcoholic Fatty Liver Disease; Uric Acid

2020
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Fructose and the Liver.
    International journal of molecular sciences, 2021, Jun-28, Volume: 22, Issue:13

    Topics: Animals; Fructose; Humans; Inflammation; Liver; NLR Family, Pyrin Domain-Containing 3 Protein; Non-a

2021
Value and Progress of Ultrasound in Diagnosis and Treatment of Hyperuricemia.
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2017, Apr-20, Volume: 39, Issue:2

    Topics: Arthritis, Gouty; Carotid Artery Diseases; Gout; Humans; Hyperuricemia; Kidney; Non-alcoholic Fatty

2017
Hyperuricemia is associated with nonalcoholic fatty liver disease activity score in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis.
    European journal of gastroenterology & hepatology, 2017, Volume: 29, Issue:9

    Topics: Adult; Biomarkers; Biopsy; Chi-Square Distribution; Female; Humans; Hyperuricemia; Liver; Male; Midd

2017
Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease?
    Current vascular pharmacology, 2018, Volume: 16, Issue:3

    Topics: Allopurinol; Atorvastatin; Biomarkers; Gout Suppressants; Humans; Hydroxymethylglutaryl-CoA Reductas

2018
Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis.
    Acta medica Indonesiana, 2017, Volume: 49, Issue:2

    Topics: Humans; Non-alcoholic Fatty Liver Disease; Severity of Illness Index; Uric Acid

2017
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.
    Journal of hepatology, 2018, Volume: 68, Issue:5

    Topics: Animals; Beverages; Carbonated Beverages; Eating; Fructokinases; Fructose; Gastrointestinal Microbio

2018
Carbohydrate intake and nonalcoholic fatty liver disease.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:4

    Topics: Animals; Beverages; Clinical Trials as Topic; Dietary Carbohydrates; Fatty Liver; Fibrosis; Humans;

2013
Effects of red wine on postprandial stress: potential implication in non-alcoholic fatty liver disease development.
    European journal of nutrition, 2015, Volume: 54, Issue:4

    Topics: Antioxidants; Biomarkers; Humans; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Postprandial

2015
Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-Analysis of Prospective Studies.
    The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Male; Metabolic Syndrome; Middle

2015
Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: A Meta-analysis of Prospective Studies.
    Scientific reports, 2015, Sep-23, Volume: 5

    Topics: Adult; Aged; Female; Humans; Hyperuricemia; Male; Metabolic Syndrome; Middle Aged; Non-alcoholic Fat

2015
Serum uric acid: a new therapeutic target for nonalcoholic fatty liver disease.
    Expert opinion on therapeutic targets, 2016, Volume: 20, Issue:3

    Topics: Animals; Drug Design; Humans; Hyperuricemia; Inflammasomes; Insulin Resistance; Metabolic Syndrome;

2016
Hyperuricemia and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis.
    European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Asian People; Biomarkers; Female; Humans; Hyperuricemia; Male; Middl

2016
Hyperuricemia and nonalcoholic fatty liver disease: from bedside to bench and back.
    Hepatology international, 2016, Volume: 10, Issue:2

    Topics: Animals; Cross-Sectional Studies; Humans; Hyperuricemia; Non-alcoholic Fatty Liver Disease; Prevalen

2016
Uric acid in metabolic syndrome: From an innocent bystander to a central player.
    European journal of internal medicine, 2016, Volume: 29

    Topics: Diabetes Mellitus; Humans; Hypertension; Hyperuricemia; Metabolic Syndrome; Non-alcoholic Fatty Live

2016
High serum uric acid and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis.
    Clinical biochemistry, 2016, Volume: 49, Issue:7-8

    Topics: Biomarkers; Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
[Studies on association between nonalcoholic fatty liver disease and hyperuricemia: current status and future prospects].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2016, Volume: 24, Issue:2

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Gout; Humans; Hyperuricemia; Non-alcoholic Fatty

2016
Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD.
    International journal of molecular sciences, 2016, Apr-12, Volume: 17, Issue:4

    Topics: Disease Progression; Ferritins; Humans; Liver Cirrhosis; Metabolic Syndrome; Non-alcoholic Fatty Liv

2016
Hyperuricaemia and risk of nonalcoholic fatty liver disease: A meta-analysis.
    Liver international : official journal of the International Association for the Study of the Liver, 2017, Volume: 37, Issue:6

    Topics: Humans; Hyperuricemia; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2017
Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.
    Mediators of inflammation, 2016, Volume: 2016

    Topics: Animals; Atherosclerosis; Disease Progression; Free Radicals; Heart Failure; Humans; Inflammasomes;

2016
Serum uric acid levels in non-alcoholic steatosis patients: a meta-analysis.
    Asia Pacific journal of clinical nutrition, 2017, Volume: 26, Issue:2

    Topics: Female; Humans; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Odds Ratio; Sensitivity and Sp

2017
Hyperuricemia is not associated with severity of liver fibrosis in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis.
    European journal of gastroenterology & hepatology, 2017, Volume: 29, Issue:6

    Topics: Biomarkers; Chi-Square Distribution; Humans; Hyperuricemia; Liver Cirrhosis; Non-alcoholic Fatty Liv

2017
Hyperuricaemia and non-alcoholic fatty liver disease (NAFLD): a relationship with implications for vascular risk?
    Current vascular pharmacology, 2011, Volume: 9, Issue:6

    Topics: Cardiovascular Diseases; Chronic Disease; Evidence-Based Medicine; Fatty Liver; Humans; Hyperuricemi

2011
Sterile inflammation in the liver.
    Gastroenterology, 2012, Volume: 143, Issue:5

    Topics: Acetaminophen; Adenosine Triphosphate; Caspase 1; Chemical and Drug Induced Liver Injury; Chemotaxis

2012

Trials

7 trials available for uric acid and Fatty Liver, Nonalcoholic

ArticleYear
Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease.
    Medicina (Kaunas, Lithuania), 2022, Nov-26, Volume: 58, Issue:12

    Topics: Citrus; Hyperuricemia; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2022
Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial.
    Diabetes, obesity & metabolism, 2020, Volume: 22, Issue:11

    Topics: Adult; Elasticity Imaging Techniques; Humans; Liver; Liver Cirrhosis; Non-alcoholic Fatty Liver Dise

2020
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome.
    World journal of gastroenterology, 2015, Jul-07, Volume: 21, Issue:25

    Topics: Adult; Biomarkers; Biopsy; Blood Glucose; Female; Greece; Humans; Hydroxymethylglutaryl-CoA Reductas

2015
Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adipose Tissue; Aged; Aging; China; Female; Humans; Hyperuricemia; Liver; Male; Middle Aged; Non-alc

2015
Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial.
    Journal of cardiovascular pharmacology, 2016, Volume: 68, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Curc

2016
Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial.
    Hepato-gastroenterology, 2012, Volume: 59, Issue:119

    Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Antioxidants; Aspartate Aminotransferases;

2012

Other Studies

138 other studies available for uric acid and Fatty Liver, Nonalcoholic

ArticleYear
The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study.
    Revista da Associacao Medica Brasileira (1992), 2021, Volume: 67, Issue:4

    Topics: Adult; Body Mass Index; Cholesterol, HDL; Humans; Non-alcoholic Fatty Liver Disease; Triglycerides;

2021
Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats.
    Food & function, 2021, Oct-04, Volume: 12, Issue:19

    Topics: Animals; Aorta; Atherosclerosis; Benzodioxoles; Cholesterol, Dietary; Diet, High-Fat; Dietary Carboh

2021
The Association between Serum Uric Acid Levels and 10-Year Cardiovascular Disease Risk in Non-Alcoholic Fatty Liver Disease Patients.
    International journal of environmental research and public health, 2022, 01-18, Volume: 19, Issue:3

    Topics: Cardiovascular Diseases; Humans; Non-alcoholic Fatty Liver Disease; Nutrition Surveys; Risk Factors;

2022
A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study.
    PeerJ, 2022, Volume: 10

    Topics: Alanine Transaminase; D-Alanine Transaminase; Humans; Non-alcoholic Fatty Liver Disease; Risk Factor

2022
Improvement in hepatic fibrosis estimated by Fibrosis-4 index in pegloticase treated chronic refractory gout patients.
    Clinical and experimental rheumatology, 2023, Volume: 41, Issue:1

    Topics: Chronic Disease; Gout; Gout Suppressants; Humans; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease

2023
Association between circulating cystatin C and hyperuricemia: a cross-sectional study.
    Clinical rheumatology, 2022, Volume: 41, Issue:7

    Topics: Aged; Cross-Sectional Studies; Cystatin C; Female; Humans; Hyperuricemia; Male; Metabolic Syndrome;

2022
Serum Uric Acid Levels and Nonalcoholic Fatty Liver Disease: A 2-Sample Bidirectional Mendelian Randomization Study.
    The Journal of clinical endocrinology and metabolism, 2022, 07-14, Volume: 107, Issue:8

    Topics: Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Non-alcoholic Fatty Liver D

2022
The Negative Association Between NAFLD Severity and CKD in a Non-Diabetic Gouty Population.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2022, Volume: 54, Issue:5

    Topics: Cross-Sectional Studies; Female; Gout; Humans; Male; Non-alcoholic Fatty Liver Disease; Renal Insuff

2022
Higher serum uric acid to HDL-cholesterol ratio is associated with onset of non-alcoholic fatty liver disease in a non-obese Chinese population with normal blood lipid levels.
    BMC gastroenterology, 2022, Apr-21, Volume: 22, Issue:1

    Topics: Body Mass Index; China; Cholesterol; Cholesterol, LDL; Humans; Lipids; Metabolic Syndrome; Non-alcoh

2022
The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population.
    Journal of physiology and biochemistry, 2023, Volume: 79, Issue:4

    Topics: Creatinine; Cross-Sectional Studies; Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Nutrit

2023
Conjunctional Relationship between Serum Uric Acid and Serum Nickel with Non-Alcoholic Fatty Liver Disease in Men: A Cross-Sectional Study.
    International journal of environmental research and public health, 2022, 05-25, Volume: 19, Issue:11

    Topics: China; Cross-Sectional Studies; Humans; Male; Nickel; Non-alcoholic Fatty Liver Disease; Prospective

2022
Serum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States.
    Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:8

    Topics: Creatinine; Cross-Sectional Studies; Elasticity Imaging Techniques; Female; Humans; Male; Non-alcoho

2022
Sex-specific metabolic risk factors and their trajectories towards the non-alcoholic fatty liver disease incidence.
    Journal of endocrinological investigation, 2022, Volume: 45, Issue:12

    Topics: Body Mass Index; Cholesterol, LDL; Female; Humans; Incidence; Male; Non-alcoholic Fatty Liver Diseas

2022
Association of serum uric acid with all-cause and cardiovascular mortality among adults with nonalcoholic fatty liver disease.
    Clinical endocrinology, 2023, Volume: 98, Issue:1

    Topics: Cardiovascular Diseases; Humans; Non-alcoholic Fatty Liver Disease; Nutrition Surveys; Uric Acid

2023
The Additive Values of the Classification of Higher Serum Uric Acid Levels as a Diagnostic Criteria for Metabolic-Associated Fatty Liver Disease.
    Nutrients, 2022, Aug-31, Volume: 14, Issue:17

    Topics: Cross-Sectional Studies; Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Ultrasonography; U

2022
Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adolescent; Child; Glucagon; Glucose; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Non-

2022
Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats.
    Chemico-biological interactions, 2022, Dec-01, Volume: 368

    Topics: Adenosine Deaminase; Animals; Antiretroviral Therapy, Highly Active; Caspase 3; Liver; Male; Non-alc

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.
    Nutrition research (New York, N.Y.), 2022, Volume: 108

    Topics: Animals; Fructose; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57

2022
Metabolic Dysfunction-Associated Fatty Liver Disease in Newly Diagnosed, Treatment-Naive Hypertensive Patients and Its Association with Cardiorenal Risk Markers.
    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2023, Volume: 30, Issue:1

    Topics: Blood Pressure; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypertension; Kidney Diseases; Ma

2023
The risk of nonalcoholic fatty liver disease in gout patients with frequent flares: a retrospective cohort study.
    Clinical rheumatology, 2023, Volume: 42, Issue:5

    Topics: Gout; Humans; Non-alcoholic Fatty Liver Disease; Retrospective Studies; Risk Factors; Uric Acid

2023
Hyperuricemia as an effect modifier of the association between metabolic phenotypes and nonalcoholic fatty liver disease in Chinese population.
    Journal of translational medicine, 2023, 01-21, Volume: 21, Issue:1

    Topics: Body Mass Index; East Asian People; Humans; Hyperuricemia; Metabolic Syndrome; Non-alcoholic Fatty L

2023
Prevalence and risk factors of hyperuricaemia in non-obese Chinese: a single-centre cross-sectional study.
    BMJ open, 2022, 06-03, Volume: 12, Issue:6

    Topics: Adult; Body Mass Index; China; Cross-Sectional Studies; East Asian People; Female; Humans; Hyperuric

2022
[Clinical significance of ultrasound combined with serological indexes for predicting nonalcoholic fatty liver disease in patients with chronic hepatitis B with normal or slightly elevated alanine aminotransferase].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2022, Nov-20, Volume: 30, Issue:11

    Topics: Alanine Transaminase; Biopsy; Clinical Relevance; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhos

2022
Noninvasive assessment of paediatric hepatic steatosis by using attenuation imaging.
    European radiology, 2023, Volume: 33, Issue:11

    Topics: Adolescent; Bayes Theorem; Child; Female; Humans; Liver; Male; Non-alcoholic Fatty Liver Disease; Ob

2023
Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity.
    Journal of pediatric endocrinology & metabolism : JPEM, 2023, Jul-26, Volume: 36, Issue:7

    Topics: Adolescent; Biomarkers; Child; Cross-Sectional Studies; Humans; Non-alcoholic Fatty Liver Disease; O

2023
Positive correlation between fatty liver index and hyperuricemia in hypertensive Chinese adults: a H-type hypertension registry study.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Adult; East Asian People; Female; gamma-Glutamyltransferase; Humans; Hypertension; Hyperuricemia; Ma

2023
Association of serum uric acid with hepatic steatosis detected by controlled attenuation parameter in the United States population.
    Lipids in health and disease, 2023, Jun-20, Volume: 22, Issue:1

    Topics: Elasticity Imaging Techniques; Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Nutrition Su

2023
Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats.
    Journal of applied biomedicine, 2023, Volume: 21, Issue:2

    Topics: Animals; Antioxidants; Atherosclerosis; Diet, High-Fat; Enzyme Inhibitors; Febuxostat; Lipids; Non-a

2023
Association between the lean nonalcoholic fatty liver disease and risk of incident type 2 diabetes in a healthy population of Northwest China: a retrospective cohort study with a 2-year follow-up period.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: China; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Middle Aged; Non-alcoholi

2023
The correlation between NAFLD and serum uric acid to serum creatinine ratio.
    PloS one, 2023, Volume: 18, Issue:7

    Topics: Adult; C-Reactive Protein; Creatinine; Humans; Non-alcoholic Fatty Liver Disease; Risk Factors; Ultr

2023
[Association between metabolism-related chronic disease combination and prevalence of non-alcoholic fatty liver disease in community residents in Shanghai].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2023, Jul-10, Volume: 44, Issue:7

    Topics: Adult; Body Mass Index; China; Chronic Disease; Diabetes Mellitus; Female; Gout; Humans; Hyperlipide

2023
Prevalence and Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease with Renal Insufficiency in Overweight/Obese Adults.
    Obesity facts, 2023, Volume: 16, Issue:6

    Topics: Adult; Female; Humans; Liver Cirrhosis; Male; Non-alcoholic Fatty Liver Disease; Obesity; Overweight

2023
FIB-4 is closer to FibroScan screen results to detecting advanced liver fibrosis and maybe facilitates NAFLD warning.
    Medicine, 2023, Aug-25, Volume: 102, Issue:34

    Topics: Cross-Sectional Studies; Elasticity Imaging Techniques; Humans; Liver Cirrhosis; Metabolic Syndrome;

2023
Association of neck circumference-related indices with metabolic, atherogenic and liver function biomarkers in patients with non-alcoholic fatty liver disease: a cross-sectional study.
    BMJ open, 2023, 09-12, Volume: 13, Issue:9

    Topics: Adult; Biomarkers; Cross-Sectional Studies; Female; Ferritins; Humans; Lipids; Male; Non-alcoholic F

2023
Correlation between serum uric acid and body fat distribution in patients with MAFLD.
    BMC endocrine disorders, 2023, Sep-25, Volume: 23, Issue:1

    Topics: Abdominal Fat; Absorptiometry, Photon; Body Fat Distribution; Humans; Hyperuricemia; Non-alcoholic F

2023
Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Myocardial Infarction; Non-alcoholic Fat

2023
Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population.
    PeerJ, 2023, Volume: 11

    Topics: Cohort Studies; East Asian People; Ferritins; Humans; Non-alcoholic Fatty Liver Disease; Uric Acid

2023
Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study.
    Obesity (Silver Spring, Md.), 2023, Volume: 31, Issue:12

    Topics: Diabetes Mellitus, Type 2; Female; Humans; Liver; Liver Cirrhosis; Male; Menopause; Middle Aged; Non

2023
Spinal epidural lipomatosis is associated with liver fat deposition and dysfunction.
    Clinical neurology and neurosurgery, 2019, Volume: 185

    Topics: Adipose Tissue; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; Bilirubi

2019
Increased plasma osteopontin levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus.
    Cytokine, 2020, Volume: 125

    Topics: Adult; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; Correlation of Data; Diabetes Mel

2020
The Prevalence of Nonalcoholic Fatty Pancreas by Endoscopic Ultrasonography.
    Pancreas, 2019, Volume: 48, Issue:9

    Topics: Adipose Tissue; Adult; Aged; Cross-Sectional Studies; Endosonography; Female; Humans; Hyperlipidemia

2019
The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats.
    Molecular nutrition & food research, 2020, Volume: 64, Issue:1

    Topics: Adipose Tissue; Animals; Diglycerides; Energy Intake; Fagopyrum; Gastrointestinal Microbiome; Hypert

2020
Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups.
    Canadian journal of gastroenterology & hepatology, 2019, Volume: 2019

    Topics: Adult; Cross-Sectional Studies; Female; Humans; Logistic Models; Menstruation; Middle Aged; Non-alco

2019
Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity.
    Journal of pediatric endocrinology & metabolism : JPEM, 2020, Feb-25, Volume: 33, Issue:2

    Topics: Adolescent; Alanine Transaminase; Biomarkers; Blood Glucose; Body Mass Index; Case-Control Studies;

2020
Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis.
    BMC gastroenterology, 2020, Feb-18, Volume: 20, Issue:1

    Topics: Allopurinol; Animals; Antimetabolites; Diet, High-Fat; Enzyme Inhibitors; Fibroblast Growth Factors;

2020
A nomogram for discrimination of non-alcoholic fatty liver disease in patients with chronic hepatitis B.
    European journal of gastroenterology & hepatology, 2021, Volume: 33, Issue:1

    Topics: Hepatitis B, Chronic; Humans; Nomograms; Non-alcoholic Fatty Liver Disease; ROC Curve; Uric Acid

2021
Exosomal miRNAs Profile in Children's Nonalcoholic Fatty Liver Disease and the Correlation with Transaminase and Uric Acid.
    Annals of nutrition & metabolism, 2020, Volume: 76, Issue:1

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Humans; Liver; MicroRNAs; Non-alcoholic Fa

2020
Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study.
    Journal of translational medicine, 2020, 03-19, Volume: 18, Issue:1

    Topics: Cohort Studies; Humans; Non-alcoholic Fatty Liver Disease; Prospective Studies; Risk Factors; Uric A

2020
Associations between obesity and metabolic health with nonalcoholic fatty liver disease in elderly Chinese.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2020, Volume: 19, Issue:3

    Topics: Aged; Blood Glucose; Blood Pressure; Body Mass Index; China; Cholesterol; Cross-Sectional Studies; F

2020
Non-alcoholic fatty liver disease: correlation with hyperuricemia in a European Mediterranean population.
    Acta clinica Belgica, 2022, Volume: 77, Issue:1

    Topics: Cross-Sectional Studies; Female; Humans; Hyperuricemia; Male; Metabolic Syndrome; Non-alcoholic Fatt

2022
Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Nonobese Postmenopausal Women: A Cross-sectional Study.
    Scientific reports, 2020, 06-22, Volume: 10, Issue:1

    Topics: Adult; Biomarkers; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Female; Humans; M

2020
Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome.
    PloS one, 2020, Volume: 15, Issue:8

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Body Mass Index; Cholesterol, HDL; Cholesterol, L

2020
Hyperuricemia precedes non-alcoholic fatty liver disease with abdominal obesity moderating this unidirectional relationship: Three longitudinal analyses.
    Atherosclerosis, 2020, Volume: 311

    Topics: Beijing; Humans; Hyperuricemia; Non-alcoholic Fatty Liver Disease; Obesity, Abdominal; Uric Acid

2020
Correlation between income and non-alcoholic fatty liver disease in a Chinese population.
    Annales d'endocrinologie, 2020, Volume: 81, Issue:6

    Topics: Adipose Tissue; Adult; Aged; Alanine Transaminase; Asian People; China; Female; Humans; Income; Life

2020
Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study.
    Lipids in health and disease, 2020, Nov-22, Volume: 19, Issue:1

    Topics: Adolescent; Alanine Transaminase; Anthropometry; Blood Glucose; Body Mass Index; Child; China; Chole

2020
Obesity interacts with hyperuricemia on the severity of non-alcoholic fatty liver disease.
    BMC gastroenterology, 2021, Jan-28, Volume: 21, Issue:1

    Topics: Body Mass Index; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Male; Non-alcoholic Fatty L

2021
Serum uric acid is positively associated with the prevalence of nonalcoholic fatty liver in non-obese type 2 diabetes patients in a Chinese population.
    Journal of diabetes and its complications, 2021, Volume: 35, Issue:5

    Topics: China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Non-alcoholic Fatty Liver Disease

2021
Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 85

    Topics: Animals; Diet, High-Fat; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Inflammation; Insulin;

2021
Study on the independent effect of thyroid hormone based on uric acid level on NAFLD.
    Journal of health, population, and nutrition, 2021, 05-03, Volume: 40, Issue:1

    Topics: Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Risk Factors; Thyroid Hormones; Triglycerid

2021
Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway.
    Scientific reports, 2021, 05-10, Volume: 11, Issue:1

    Topics: Allopurinol; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoplasmic

2021
Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Biomarkers; China; Female; Follow-Up Studies; Humans; Incidence; Longitudinal Studies; Male; Middle

2021
Relationship between serum uric acid level and nonalcoholic fatty liver disease in type 2 diabetes patients.
    Medicine, 2021, Aug-20, Volume: 100, Issue:33

    Topics: Biomarkers; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Lipid Metabolism;

2021
Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia.
    Medicine, 2017, Volume: 96, Issue:12

    Topics: Adult; Aged; China; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hypertriglyceridemia; H

2017
Cytokeratin-18 and uric acid predicts disease severity in Taiwanese nonalcoholic steatohepatitis patients.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Adult; Biomarkers; Female; Humans; Keratin-18; Male; Middle Aged; Non-alcoholic Fatty Liver Disease;

2017
Vildagliptin: any effect on non-alcoholic fatty liver disease and serum uric acid? Re: Shelbaya S, Rakha S. Effectiveness and safety of vildagliptin and vildagliptin add-on to metformin in real-world settings in Egypt - results from the GUARD study. Curr
    Current medical research and opinion, 2017, Volume: 33, Issue:12

    Topics: Adamantane; Egypt; Humans; Metformin; Non-alcoholic Fatty Liver Disease; Uric Acid; Vildagliptin

2017
Reply to: "Fructose, uric acid and zonal differences in NASH".
    Journal of hepatology, 2017, Volume: 67, Issue:5

    Topics: Fructose; Humans; Non-alcoholic Fatty Liver Disease; Uric Acid

2017
Fructose, uric acid, and zonal differences in NASH.
    Journal of hepatology, 2017, Volume: 67, Issue:5

    Topics: Adolescent; Child; Fructose; Humans; Non-alcoholic Fatty Liver Disease; Uric Acid

2017
Gender difference on the relationship between hyperuricemia and nonalcoholic fatty liver disease among Chinese: An observational study.
    Medicine, 2017, Volume: 96, Issue:39

    Topics: Anthropometry; Blood Pressure Determination; China; Female; Humans; Hyperuricemia; Liver Function Te

2017
NAFL screening score: A basic score identifying ultrasound-diagnosed non-alcoholic fatty liver.
    Clinica chimica acta; international journal of clinical chemistry, 2017, Volume: 475

    Topics: Adult; Alanine Transaminase; Area Under Curve; Aspartate Aminotransferases; Biomarkers; Blood Glucos

2017
Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults.
    Lipids in health and disease, 2017, Oct-16, Volume: 16, Issue:1

    Topics: Adult; Area Under Curve; Biomarkers; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Female; Hu

2017
Energy drinks and adolescents - A hepatic health hazard?
    Journal of hepatology, 2018, Volume: 68, Issue:4

    Topics: Adolescent; Child; Energy Drinks; Fructose; Humans; Non-alcoholic Fatty Liver Disease; Surveys and Q

2018
Liver zonation in children with non-alcoholic fatty liver disease: Associations with dietary fructose and uric acid concentrations.
    Liver international : official journal of the International Association for the Study of the Liver, 2018, Volume: 38, Issue:6

    Topics: Adolescent; Child; Diet; Female; Fructose; Humans; Hyperuricemia; Liver; Logistic Models; Male; Non-

2018
Risk for the development of non-alcoholic fatty liver disease: A prospective study.
    Journal of gastroenterology and hepatology, 2018, Volume: 33, Issue:8

    Topics: Abdomen; Adult; Alanine Transaminase; Aspartate Aminotransferases; Body Mass Index; China; Cohort St

2018
Prevalence and clinical characteristics of non-alcoholic fatty liver disease in newly diagnosed patients with ketosis-onset diabetes.
    Diabetes & metabolism, 2018, Volume: 44, Issue:5

    Topics: Adult; Aged; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ

2018
Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity.
    Journal of Korean medical science, 2018, Apr-16, Volume: 33, Issue:16

    Topics: Adolescent; Age of Onset; Anthropometry; Blood Pressure; Child; Child, Preschool; Cholesterol; Femal

2018
Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism.
    Metabolism: clinical and experimental, 2018, Volume: 85

    Topics: Animals; Apolipoproteins E; Carnitine; Diet, High-Fat; Energy Metabolism; Male; Mice; Mice, Knockout

2018
Shall we diagnose metabolic syndrome in adolescents?
    Neuro endocrinology letters, 2018, Volume: 39, Issue:2

    Topics: Adolescent; Biomarkers; Blood Glucose; Body Mass Index; Cholesterol, HDL; Female; Humans; Insulin Re

2018
[Correlation between serum uric acid and risk of new-onset nonalcoholic fatty liver disease: a 5-year observational cohort study].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2018, Apr-20, Volume: 26, Issue:4

    Topics: China; Cohort Studies; Humans; Incidence; Non-alcoholic Fatty Liver Disease; Risk Factors; Triglycer

2018
Nonalcoholic Fatty Liver Disease Is Associated with Increased Atrial Fibrillation Risk in an Elderly Chinese Population: A Cross-Sectional Study.
    BioMed research international, 2018, Volume: 2018

    Topics: Adult; Aged; Atrial Fibrillation; China; Cross-Sectional Studies; Female; Humans; Male; Non-alcoholi

2018
Liver stiffness assessed by transient elastography as a potential indicator of chronic kidney disease in patients with nonalcoholic fatty liver disease.
    Journal of clinical laboratory analysis, 2019, Volume: 33, Issue:2

    Topics: Cohort Studies; Diabetes Complications; Elasticity Imaging Techniques; Female; Humans; Liver; Male;

2019
Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study.
    Journal of translational medicine, 2018, 10-17, Volume: 16, Issue:1

    Topics: Adult; Aged; Alanine Transaminase; China; Cross-Sectional Studies; Female; Humans; Male; Middle Aged

2018
The severity of NAFLD is associated with the risk of urolithiasis.
    British journal of biomedical science, 2019, Volume: 76, Issue:2

    Topics: Aged; Alcohol Drinking; Aspartate Aminotransferases; Blood Platelets; China; Electronic Health Recor

2019
Salivary markers of hepato-metabolic comorbidities in pediatric obesity.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2019, Volume: 51, Issue:4

    Topics: Adolescent; Biomarkers; Child; Comorbidity; Female; Glucose; Homeostasis; Humans; Insulin; Insulin R

2019
Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.
    The Journal of biological chemistry, 2019, 03-15, Volume: 294, Issue:11

    Topics: Adipose Tissue; Aldehyde Reductase; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Fr

2019
Interactions between the cecal microbiota and non-alcoholic steatohepatitis using laying hens as the model.
    Poultry science, 2019, Jun-01, Volume: 98, Issue:6

    Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bacteria; Cecum; Chickens; Disease Model

2019
Dietary patterns and non-alcoholic fatty liver disease in a Greek case-control study.
    Nutrition (Burbank, Los Angeles County, Calif.), 2019, Volume: 61

    Topics: Adult; C-Reactive Protein; Case-Control Studies; Diet; Diet Surveys; Feeding Behavior; Female; Greec

2019
Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD).
    Revista espanola de enfermedades digestivas, 2019, Volume: 111, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Body Mass Index; Chol

2019
Pilot study: asymptomatic hyperuricemia patients with obesity and nonalcoholic fatty liver disease have increased risk of double contour sign.
    The Korean journal of internal medicine, 2020, Volume: 35, Issue:6

    Topics: Gout; Humans; Hyperuricemia; Non-alcoholic Fatty Liver Disease; Obesity; Pilot Projects; Ultrasonogr

2020
Gender effect of hyperuricemia on the development of nonalcoholic fatty liver disease (NAFLD): A clinical analysis and mechanistic study.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 117

    Topics: Adult; Animals; Female; Humans; Hyperuricemia; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver D

2019
Association of obesity with chronic kidney disease in elderly patients with nonalcoholic fatty liver disease.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2019, Volume: 30, Issue:7

    Topics: Age Factors; Aged; Biomarkers; Body Mass Index; Cross-Sectional Studies; Female; Humans; Kidney Func

2019
Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women.
    Annals of nutrition & metabolism, 2013, Volume: 62, Issue:2

    Topics: Adult; Alanine Transaminase; Asian People; Aspartate Aminotransferases; Body Mass Index; Cholesterol

2013
Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Adult; Aged; Asian People; China; Confidence Intervals; Diabetes Mellitus; Fatty Liver; Humans; Line

2013
Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China.
    Arquivos brasileiros de endocrinologia e metabologia, 2013, Volume: 57, Issue:8

    Topics: Adult; Body Mass Index; China; Fatty Liver; Feeding Behavior; Female; Humans; Hyperuricemia; Life St

2013
Increased catabolism of nucleic acid in nonalcoholic fatty liver disease patients of different ages.
    International journal of biological macromolecules, 2014, Volume: 65

    Topics: Adult; Age Distribution; Case-Control Studies; Female; Humans; Male; Middle Aged; Non-alcoholic Fatt

2014
The prevalence of nonalcoholic fatty liver disease and relationship with serum uric acid level in Uyghur population.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: Adult; Aged; China; Cross-Sectional Studies; Ethnicity; Female; Health Surveys; Humans; Male; Middle

2014
The relationship of serum uric acid with non-alcoholic fatty liver disease.
    Clinical biochemistry, 2014, Volume: 47, Issue:6

    Topics: Adult; Anthropometry; Humans; Hyperuricemia; Male; Multivariate Analysis; Non-alcoholic Fatty Liver

2014
[Relationship between normal serum uric acid levels and nonalcoholic fatty liver disease in postmenopausal women].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2014, Volume: 22, Issue:1

    Topics: Aged; Female; Humans; Middle Aged; Non-alcoholic Fatty Liver Disease; Postmenopause; Retrospective S

2014
Uric acid levels decrease with fibrosis progression in patients with nonalcoholic fatty liver disease.
    Clinical biochemistry, 2014, Volume: 47, Issue:12

    Topics: Humans; Male; Non-alcoholic Fatty Liver Disease; Uric Acid

2014
Relationship between serum uric acid levels and hepatic steatosis in non-obese postmenopausal women.
    Climacteric : the journal of the International Menopause Society, 2014, Volume: 17, Issue:6

    Topics: Adult; Aged; Blood Pressure; Body Mass Index; China; Cross-Sectional Studies; Diabetes Mellitus, Typ

2014
Importance of the selected cut-offs for serum uric acid and lipids levels.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: Ethnicity; Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Uric Acid

2014
Oral fructose absorption in obese children with non-alcoholic fatty liver disease.
    Pediatric obesity, 2015, Volume: 10, Issue:3

    Topics: Adolescent; Biomarkers; Blood Glucose; Body Mass Index; Breath Tests; Child; Eating; Female; Fructos

2015
The significance of serum xanthine oxidoreductase in patients with nonalcoholic fatty liver disease.
    Clinical laboratory, 2014, Volume: 60, Issue:8

    Topics: Adult; Anthropometry; Case-Control Studies; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Ass

2014
Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Adolescent; Blood Pressure Determination; Chi-Square Distribution; Child; Child, Preschool; Choleste

2014
Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome.
    Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:6

    Topics: Abdomen; Adult; Aged; Alanine Transaminase; Alcohol Drinking; Asian People; Aspartate Aminotransfera

2015
[CORRECTION OF BILE FLOW CHARACTERISTICS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH HYPERURICEMIA].
    Likars'ka sprava, 2014, Issue:11

    Topics: Adult; Allopurinol; Bile; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Cholesterol; Choli

2014
Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds.
    Journal of hepatology, 2015, Volume: 62, Issue:6

    Topics: Adult; Animals; Carrier Proteins; Cohort Studies; Disease Models, Animal; Female; Gene Knockdown Tec

2015
Serum uric acid and non-alcoholic fatty liver disease in non-hypertensive Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:2

    Topics: Adult; Asian People; Biomarkers; China; Female; Humans; Hypertension; Male; Non-alcoholic Fatty Live

2015
Association between serum uric acid and nonalcoholic fatty liver disease in the US population.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2015, Volume: 114, Issue:4

    Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Female; Humans; Hyperuricemia; Logis

2015
The association between the serum levels of uric acid and alanine aminotransferase in a population-based cohort.
    Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:11

    Topics: Adult; Alanine Transaminase; Biomarkers; Body Mass Index; Cross-Sectional Studies; Databases, Factua

2015
Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study.
    Medicine, 2015, Volume: 94, Issue:17

    Topics: Adult; Causality; China; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Middle

2015
The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
    American journal of physiology. Gastrointestinal and liver physiology, 2015, Jul-01, Volume: 309, Issue:1

    Topics: Animals; Apoptosis; Choline Deficiency; Cytoprotection; Diet, High-Fat; Enzyme Inhibitors; Febuxosta

2015
Association between serum uric acid and nonalcoholic fatty liver disease.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016, Volume: 115, Issue:2

    Topics: Fatty Liver; Humans; Liver; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
Correlation between non-alcoholic fatty liver with metabolic risk factors and brachial-ankle pulse wave velocity.
    World journal of gastroenterology, 2015, Sep-21, Volume: 21, Issue:35

    Topics: Adult; Aged; Ankle Brachial Index; Biomarkers; Blood Glucose; Blood Pressure; Chi-Square Distributio

2015
Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Adult; Aged; Albuminuria; Comorbidity; Cytokines; Diabetes Mellitus, Type 2; Diabetic Nephropathies;

2015
Vitamin D Status and Bone Mineral Density in Obese Children with Nonalcoholic Fatty Liver Disease.
    Journal of Korean medical science, 2015, Volume: 30, Issue:12

    Topics: Adolescent; Adult; Body Composition; Bone Density; C-Reactive Protein; Child; Female; Humans; Insuli

2015
The relationship between serum uric acid levels and the major risk factors for the development of nonalcoholic fatty liver disease.
    Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:5

    Topics: Humans; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
Uric acid in nonalcoholic fatty liver disease.
    European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:5

    Topics: Fatty Liver; Humans; Liver; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
Influence of light alcohol consumption on lifestyle-related diseases: a predictor of fatty liver with liver enzyme elevation in Japanese females with metabolic syndrome.
    BMC gastroenterology, 2016, Feb-18, Volume: 16

    Topics: Alanine Transaminase; Alcohol Drinking; Blood Glucose; Blood Pressure; Body Mass Index; Female; Huma

2016
Response to The relationship between serum uric acid levels and NAFLD.
    Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:5

    Topics: Humans; Hyperuricemia; Non-alcoholic Fatty Liver Disease; Uric Acid

2016
Insulin resistance, body composition, and fat distribution in obese children with nonalcoholic fatty liver disease.
    Asia Pacific journal of clinical nutrition, 2016, Volume: 25, Issue:1

    Topics: Abdominal Fat; Absorptiometry, Photon; Adolescent; Alanine Transaminase; Aspartate Aminotransferases

2016
Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study.
    World journal of gastroenterology, 2016, Apr-07, Volume: 22, Issue:13

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Body Mass Index; China; Cholesterol, HDL; Cholesterol, LDL;

2016
Urine uric acid excretion is associated with nonalcoholic fatty liver disease in patients with type 2 diabetes.
    Journal of diabetes and its complications, 2016, Volume: 30, Issue:6

    Topics: Adult; Aged; Asian People; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans

2016
Risk factor compositions of nonalcoholic fatty liver disease change with body mass index in males and females.
    Oncotarget, 2016, Jun-14, Volume: 7, Issue:24

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Blood Glucose; Body Mass Index; Cholestero

2016
The Risk Factor Analysis for Type 2 Diabetes Mellitus Patients with Nonalcoholic Fatty Liver Disease and Positive Correlation with Serum Uric Acid.
    Cell biochemistry and biophysics, 2015, Volume: 72, Issue:3

    Topics: Adult; Aged; Biomarkers; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Female; H

2015
Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients.
    Journal of diabetes research, 2016, Volume: 2016

    Topics: Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Liver; Male; Middle

2016
Uncovered issues in the association between uric acid and nonalcoholic fatty liver disease.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016, Volume: 115, Issue:11

    Topics: Fatty Liver; Humans; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid

2016
Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Adult; Aged; Asian People; China; Comorbidity; Diabetes Mellitus; Humans; Hyperlipidemias; Hypertens

2016
A rapid and high-throughput method for the determination of serum uric acid based on microarray technology and nanomaterial.
    Luminescence : the journal of biological and chemical luminescence, 2017, Volume: 32, Issue:5

    Topics: Allantoin; Biosensing Techniques; Cobalt; Enzymes, Immobilized; High-Throughput Screening Assays; Hu

2017
Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents.
    Acta paediatrica (Oslo, Norway : 1992), 2017, Volume: 106, Issue:2

    Topics: Adolescent; Biomarkers; Body Mass Index; Child; Cross-Sectional Studies; Female; Humans; Insulin Res

2017
Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults.
    Scientific reports, 2016, 12-07, Volume: 6

    Topics: Aged; Biomarkers; China; Disease Susceptibility; Female; Humans; Insulin Resistance; Life Style; Mal

2016
Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.
    Journal of hepatology, 2017, Volume: 66, Issue:5

    Topics: Adolescent; Child; Female; Fructose; Humans; Insulin Resistance; Logistic Models; Male; Non-alcoholi

2017
Gout and risk of non-alcoholic fatty liver disease.
    Scandinavian journal of rheumatology, 2010, Volume: 39, Issue:6

    Topics: Adult; Aged; Body Mass Index; Cross-Sectional Studies; Fatty Liver; Female; Glomerular Filtration Ra

2010
The relationship between normal serum uric acid and nonalcoholic fatty liver disease.
    Journal of Korean medical science, 2011, Volume: 26, Issue:3

    Topics: Adult; Fatty Liver; Female; Humans; Liver Function Tests; Logistic Models; Male; Middle Aged; Non-al

2011
Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese.
    Clinical endocrinology, 2011, Volume: 75, Issue:2

    Topics: Aged; Asian People; Body Mass Index; Cross-Sectional Studies; Fatty Liver; Humans; Non-alcoholic Fat

2011
Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease.
    Alimentary pharmacology & therapeutics, 2011, Volume: 34, Issue:7

    Topics: Adult; Anthropometry; Biomarkers; Biopsy; Cohort Studies; Fatty Liver; Female; Humans; Hyperuricemia

2011
Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 54, Issue:1

    Topics: Adolescent; Ascorbic Acid; Child; Cross-Sectional Studies; Diet; Dietary Sucrose; Energy Intake; Fat

2012
Renal function-dependent association of serum uric acid with metabolic syndrome and hepatic fat content in a middle-aged and elderly Chinese population.
    Clinical and experimental pharmacology & physiology, 2012, Volume: 39, Issue:11

    Topics: Aged; Asian People; Cohort Studies; Cross-Sectional Studies; Fatty Liver; Female; Glomerular Filtrat

2012
Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:3

    Topics: Adult; Aged; Aspartate Aminotransferases; Cholesterol, HDL; Cross-Sectional Studies; Fatty Liver; Fe

2013