uric acid has been researched along with Down Syndrome in 50 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the influence of a 12-week training programme on plasmatic levels of allantoin, an in vivo marker for oxidative stress, in adolescents with Down syndrome." | 7.76 | A 12-week aerobic training programme reduced plasmatic allantoin in adolescents with Down syndrome. ( Diaz, A; Fornieles-Gonzalez, G; Ordonez, FJ; Rosety, I; Rosety, M; Rosety-Rodriguez, M, 2010) |
| "To evaluate the urinary levels of uric acid (UA) and total antioxidant capacity (TAC) with and without UA relative contribution (TAC(-UA)) in children and adults with Down syndrome (DS) and to prove the clinical use of TAC." | 7.76 | Urinary uric acid and antioxidant capacity in children and adults with Down syndrome. ( Campos, C; Casado, A; Guzmán, R; López-Fernández, E, 2010) |
| "Allantoin is a nonenzymatic oxidative product of uric acid in human." | 5.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
| "To assess the influence of a 12-week training programme on plasmatic levels of allantoin, an in vivo marker for oxidative stress, in adolescents with Down syndrome." | 3.76 | A 12-week aerobic training programme reduced plasmatic allantoin in adolescents with Down syndrome. ( Diaz, A; Fornieles-Gonzalez, G; Ordonez, FJ; Rosety, I; Rosety, M; Rosety-Rodriguez, M, 2010) |
| "To evaluate the urinary levels of uric acid (UA) and total antioxidant capacity (TAC) with and without UA relative contribution (TAC(-UA)) in children and adults with Down syndrome (DS) and to prove the clinical use of TAC." | 3.76 | Urinary uric acid and antioxidant capacity in children and adults with Down syndrome. ( Campos, C; Casado, A; Guzmán, R; López-Fernández, E, 2010) |
| "The aim of this investigation was to examine the effect of aerobic exercise (AE) on uric acid (UA), total antioxidant activity (TAA), oxidative stress (OS) and nitrite a stable nitric oxide (NO) metabolite in saliva from persons with Down syndrome (DS)." | 3.75 | Aerobic exercise reduced oxidative stress in saliva of persons with Down syndrome. ( Marquina, R; Reyes, RA; Rodríguez-Malaver, AJ; Sulbarán, N; Zambrano, JC, 2009) |
| "To evaluate the levels of thiobarbituric acid reactive substances (TBARS), uric acid, and seric superoxide dismutase and catalase activities, as well as total serum iron, total iron-binding capacity (TIBC), erythrocyte osmotic fragility, and hemograms in people with Down syndrome." | 3.73 | Oxidative stress and hematologic and biochemical parameters in individuals with Down syndrome. ( Garcez, ME; Peres, W; Salvador, M, 2005) |
| "As the life expectancy of people with intellectual disability (ID) increases, it is becoming necessary to understand factors affecting survival." | 1.39 | Predictors, including blood, urine, anthropometry, and nutritional indices, of all-cause mortality among institutionalized individuals with intellectual disability. ( Nakayama, T; Ohwada, H; Tomono, Y; Yamanaka, K, 2013) |
| " To evaluate the biochemical responses of children with Down Syndrome to a nutritional regimen supplemented with aminoacids, vitamins and polyunsaturated fatty acids, we submitted 86 subjects divided in two groups (0-6 and 6-12 years) to the dosage of plasma levels of aminoacids, antioxidant enzymes activities and reactive oxygen species, before and after 12 months of such nutritional supplementation and in relation to normal controls." | 1.32 | Aminoacid profile and oxidative status in children affected by Down syndrome before and after supplementary nutritional treatment. ( Bono, A; Ciaccio, M; Corsello, G; Giuffrè, M; Macaione, V; Piccione, M; Vocca, L, 2003) |
| "Allantoin is a nonenzymatic oxidative product of uric acid in human." | 1.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
| "Uric acid clearance was decreased to 3." | 1.26 | A case of gouty arthritis associated with Down's syndrome. ( Aikawa, T; Akaoka, I; Horiuchi, Y; Maruki, M; Mitamura, T; Nishida, Y; Nishizawa, T; Yokohari, R, 1976) |
| "Hyperuricaemia in Down's syndrome is unreleated to the activity of phosphoribosylamidotransfrease, which catalyses the activity of the first specific step on the purine biosynthetic pathway, and to the activity of hypoxanthine phosphoribosyltransferase and phosphoribosylpyrophosphate synthetase, abnormalities of which are known to be associated with hyperuricaemia." | 1.26 | Immunological and purine enzyme studies on hyperuricaemic and normouricaemic patients with Down's syndrome. ( Allsop, J; Newton, C; Perera, YS; Platts-Mills, TA; Watts, RW; Webster, AD, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (70.00) | 18.7374 |
| 1990's | 2 (4.00) | 18.2507 |
| 2000's | 7 (14.00) | 29.6817 |
| 2010's | 6 (12.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garlet, TR | 2 |
| Parisotto, EB | 2 |
| de Medeiros, Gda S | 1 |
| Pereira, LC | 1 |
| Moreira, EA | 1 |
| Dalmarco, EM | 1 |
| Dalmarco, JB | 1 |
| Wilhelm Filho, D | 2 |
| Cavalli, VL | 1 |
| Zamoner, A | 1 |
| da Rosa, JS | 1 |
| Bastos, J | 1 |
| Micke, GA | 1 |
| Fröde, TS | 1 |
| Pedrosa, RC | 1 |
| de Sousa, MC | 1 |
| Vieira, RB | 1 |
| Dos Santos, DS | 1 |
| Carvalho, CA | 1 |
| Camargo, SE | 1 |
| Mancini, MN | 1 |
| de Oliveira, LD | 1 |
| Rosety-Rodriguez, M | 1 |
| Rosety, I | 1 |
| Fornieles-Gonzalez, G | 1 |
| Diaz, A | 1 |
| Rosety, M | 1 |
| Ordonez, FJ | 1 |
| Tiano, L | 1 |
| Padella, L | 1 |
| Carnevali, P | 1 |
| Gabrielli, O | 1 |
| Bruge, F | 1 |
| Principi, F | 1 |
| Littarru, GP | 1 |
| Zambrano, JC | 1 |
| Marquina, R | 1 |
| Sulbarán, N | 1 |
| Rodríguez-Malaver, AJ | 1 |
| Reyes, RA | 1 |
| Campos, C | 1 |
| Guzmán, R | 1 |
| López-Fernández, E | 1 |
| Casado, A | 1 |
| Ohwada, H | 1 |
| Nakayama, T | 1 |
| Tomono, Y | 1 |
| Yamanaka, K | 1 |
| Okabe, H | 1 |
| Mizuguchi, M | 1 |
| FULLER, RW | 2 |
| LUCE, MW | 2 |
| MERTZ, ET | 5 |
| CONCON, JM | 1 |
| LESCH, M | 1 |
| NYHAN, WL | 2 |
| APPLETON, MD | 2 |
| HAAB, W | 2 |
| CASEY, PJ | 1 |
| CASTELLINO, FJ | 1 |
| SCHORR, JM | 1 |
| MIRAGLIA, RJ | 1 |
| CHAPMAN, MJ | 1 |
| STERN, J | 1 |
| COBURN, SP | 3 |
| Ciaccio, M | 1 |
| Piccione, M | 1 |
| Giuffrè, M | 1 |
| Macaione, V | 1 |
| Vocca, L | 1 |
| Bono, A | 1 |
| Corsello, G | 1 |
| Zitnanová, I | 1 |
| Korytár, P | 1 |
| Aruoma, OI | 1 |
| Sustrová, M | 2 |
| Garaiová, I | 1 |
| Muchová, J | 1 |
| Kalnovicová, T | 1 |
| Pueschel, S | 1 |
| Duracková, Z | 1 |
| Garcez, ME | 1 |
| Peres, W | 1 |
| Salvador, M | 1 |
| Puukka, R | 1 |
| Puukka, M | 1 |
| Leppilampi, M | 1 |
| Linna, SL | 1 |
| Kouvalainen, K | 1 |
| Ciompi, ML | 1 |
| Bazzichi, LM | 1 |
| Bertolucci, D | 1 |
| Mazzoni, MR | 1 |
| Barbieri, P | 1 |
| Mencacci, S | 1 |
| Macchia, D | 1 |
| Mariani, G | 1 |
| Tanaka, Y | 1 |
| Shibata, R | 1 |
| Sakamoto, K | 1 |
| Nagyová, A | 1 |
| Raslová, K | 1 |
| Kucera, J | 1 |
| Nishida, Y | 3 |
| Akaoka, I | 3 |
| Nishizawa, T | 3 |
| Maruki, M | 3 |
| Aikawa, T | 1 |
| Mitamura, T | 1 |
| Yokohari, R | 1 |
| Horiuchi, Y | 1 |
| Maruki, K | 2 |
| Watts, RW | 2 |
| Perera, YS | 1 |
| Allsop, J | 1 |
| Newton, C | 1 |
| Platts-Mills, TA | 1 |
| Webster, AD | 1 |
| Eberhard, Y | 1 |
| Eterradossi, J | 1 |
| Therminarias, A | 1 |
| Brás, A | 1 |
| Monteiro, C | 1 |
| Rueff, J | 1 |
| Burti, U | 1 |
| Orsulak, PJ | 1 |
| Rosner, F | 1 |
| Ong, BH | 1 |
| Paine, RS | 1 |
| Mahanand, D | 1 |
| Danton, RA | 1 |
| Khalil, M | 1 |
| el-Khateeb, S | 1 |
| Aref, GH | 1 |
| Guirgis, FK | 1 |
| Kaufman, JM | 1 |
| O'Brien, WM | 1 |
| Rundle, AT | 1 |
| Fannin, CV | 1 |
| Seidenberg, M | 1 |
| Pant, SS | 1 |
| Moser, HW | 1 |
| Krane, SM | 1 |
| Lis, AW | 1 |
| Bijan, R | 1 |
| Lis, EW | 1 |
| De Hackbeil, KF | 1 |
| Sirlin, EM | 1 |
| Paulson, GW | 2 |
| Nance, W | 1 |
| Son, C | 1 |
| Son, CD | 1 |
| Nance, WE | 1 |
| Sorensen, LB | 1 |
| Ebadi, MS | 1 |
| Kugel, RB | 1 |
| Kekre, S | 1 |
| Singh, SD | 1 |
| Chhaparwal, BC | 1 |
| Pohowalla, JN | 1 |
| Tada, K | 1 |
| Uesaki, T | 1 |
| Isshiki, G | 1 |
| Oura, T | 1 |
| Pasero, GP | 1 |
| Ciompi, MI | 1 |
| Howell, A | 1 |
| Mason, AS | 1 |
| Brown, E | 1 |
| Chanarin, I | 1 |
| McPherson, K | 1 |
| Ridler, MA | 1 |
| Cayla, J | 1 |
| Rondier, J | 1 |
| Auscher, C | 1 |
| Perreau, C | 1 |
| de Gery, A | 1 |
| Klebba, JT | 1 |
| Gershbein, LL | 1 |
| Marks, R | 1 |
| Ryckewaert, A | 1 |
| Kuntz, D | 1 |
4 reviews available for uric acid and Down Syndrome
| Article | Year |
|---|---|
[Secondary hyperuricemia in Down's syndrome].
Topics: Diet; Down Syndrome; Humans; Hyperuricemia; Kidney; Uric Acid; Uricosuric Agents | 2003 |
Hyperuricemia and gout.
Topics: Biological Transport; Carbohydrate Metabolism, Inborn Errors; Down Syndrome; Fructose; Glucosyltrans | 1969 |
Uric acid studies in serum and cerebrospinal fluid in neurological disorders with mental retardation.
Topics: Carbohydrate Metabolism, Inborn Errors; Central Nervous System Diseases; Cerebral Palsy; Child; Chil | 1971 |
[Hyperuricemia in childhood].
Topics: Anemia, Hemolytic; Child; Down Syndrome; Glycogen Storage Disease; Gout; Humans; Kidney Calculi; Kid | 1973 |
46 other studies available for uric acid and Down Syndrome
| Article | Year |
|---|---|
Systemic oxidative stress in children and teenagers with Down syndrome.
Topics: Antioxidants; Biomarkers; Case-Control Studies; Child; Child, Preschool; Down Syndrome; Female; Huma | 2013 |
Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome.
Topics: Adolescent; Antioxidants; Ascorbic Acid; Biomarkers; Case-Control Studies; Catalase; Child; Child, P | 2014 |
Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome.
Topics: Adolescent; Antioxidants; Ascorbic Acid; Biomarkers; Case-Control Studies; Down Syndrome; Female; Hu | 2015 |
A 12-week aerobic training programme reduced plasmatic allantoin in adolescents with Down syndrome.
Topics: Adolescent; Allantoin; Case-Control Studies; Down Syndrome; Exercise; Exercise Therapy; Humans; Male | 2010 |
Coenzyme Q10 and oxidative imbalance in Down syndrome: biochemical and clinical aspects.
Topics: Allantoin; Child; Child, Preschool; Down Syndrome; Humans; Oxidative Stress; Ubiquinone; Uric Acid | 2008 |
Aerobic exercise reduced oxidative stress in saliva of persons with Down syndrome.
Topics: Adolescent; Antioxidants; Down Syndrome; Exercise; Exercise Test; Female; Humans; Male; Nitric Oxide | 2009 |
Urinary uric acid and antioxidant capacity in children and adults with Down syndrome.
Topics: Adolescent; Adult; Antioxidants; Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; Mal | 2010 |
Predictors, including blood, urine, anthropometry, and nutritional indices, of all-cause mortality among institutionalized individuals with intellectual disability.
Topics: Adult; Aged; Anthropometry; Calcium; Cholesterol; Down Syndrome; Epilepsy; Female; Follow-Up Studies | 2013 |
Serum uric acid in mongolism.
Topics: Asian People; Down Syndrome; Humans; Intellectual Disability; Male; Uric Acid | 1962 |
Serum uric acid in young mongoloids.
Topics: Asian People; Down Syndrome; Humans; Uric Acid | 1963 |
A FAMILIAL DISORDER OF URIC ACID METABOLISM AND CENTRAL NERVOUS SYSTEM FUNCTION.
Topics: Athetosis; Biomedical Research; Blood Chemical Analysis; Central Nervous System Diseases; Cerebral P | 1964 |
ROLE OF VITAMIN A IN GAMMA GLOBULIN BIOSYNTHESIS AND URIC ACID METABOLISM OF MONGOLOIDS.
Topics: Blood; Body Fluids; Down Syndrome; gamma-Globulins; Intellectual Disability; Proteins; Purines; Rats | 1964 |
URIC ACID IN DOWN'S DISEASE.
Topics: Adolescent; Blood Chemical Analysis; Body Fluids; Child; Creatine; Creatinine; Down Syndrome; Humans | 1964 |
ELEVATED LEVELS OF SEVERAL NITROGENOUS NON-PROTEIN METABOLITES IN MONGOLOID BLOOD.
Topics: Blood Chemical Analysis; Blood Glucose; Blood Urea Nitrogen; Creatine; Creatinine; Down Syndrome; Hu | 1965 |
Aminoacid profile and oxidative status in children affected by Down syndrome before and after supplementary nutritional treatment.
Topics: Age Factors; Amino Acids; Antioxidants; Child; Child, Preschool; Dietary Supplements; Down Syndrome; | 2003 |
Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
Topics: Adolescent; Aging; Allantoin; Antioxidants; Child; Chromatography, High Pressure Liquid; Down Syndro | 2004 |
Oxidative stress and hematologic and biochemical parameters in individuals with Down syndrome.
Topics: Adolescent; Adult; Case-Control Studies; Catalase; Child; Child, Preschool; Down Syndrome; Female; H | 2005 |
Erythrocyte adenosine deaminase, purine nucleoside phosphorylase and phosphoribosyltransferase activity in patients with Down's syndrome.
Topics: Adenine Nucleotides; Adenine Phosphoribosyltransferase; Adenosine Deaminase; Adolescent; Adult; Chil | 1982 |
Uric acid metabolism in two patients with coexistent Down's syndrome and gout.
Topics: Adult; Down Syndrome; Glomerular Filtration Rate; Gout; Humans; Male; Uric Acid | 1984 |
[A case of Down syndrome with chronic renal failure caused by long-term asymptomatic hyperuricemia].
Topics: Adult; Down Syndrome; Humans; Kidney Failure, Chronic; Male; Uric Acid | 1993 |
Serum lipid resistance to oxidation and uric acid levels in subjects with Down's syndrome.
Topics: Adolescent; Adult; Down Syndrome; Female; Humans; Lipid Metabolism; Lipids; Male; Oxidation-Reductio | 2000 |
[Hyperuricemia in Down's syndrome (etiology, significance, and possibilities of its modification)].
Topics: Adolescent; Analysis of Variance; Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; In | 1976 |
A case of gouty arthritis associated with Down's syndrome.
Topics: Adult; Down Syndrome; Gout; Humans; Karyotyping; Kidney Function Tests; Male; Metabolic Clearance Ra | 1976 |
Hyperlipidaemia in patients with Down's syndrome.
Topics: Adolescent; Adult; Cholesterol; Down Syndrome; Fatty Acids, Nonesterified; Humans; Hyperlipidemias; | 1977 |
Synthesis and concentration of 5-phosphoribosyl-1-pyrophosphate in erythrocytes from patients with Down's syndrome.
Topics: Adolescent; Adult; Child; Down Syndrome; Erythrocytes; Female; Glucose; Glucosephosphate Dehydrogena | 1977 |
Immunological and purine enzyme studies on hyperuricaemic and normouricaemic patients with Down's syndrome.
Topics: Adolescent; Adult; Amidophosphoribosyltransferase; Down Syndrome; Erythrocytes; Female; Humans; Hype | 1979 |
Biochemical changes and catecholamine responses in Down's syndrome adolescents in relation to incremental maximal exercise.
Topics: Adolescent; Blood Glucose; Down Syndrome; Energy Metabolism; Epinephrine; Exercise; Exercise Test; F | 1991 |
Oxidative stress in trisomy 21. A possible role in cataractogenesis.
Topics: Adolescent; Adult; Ascorbic Acid; Cataract; Child; Child, Preschool; Down Syndrome; Erythrocytes; Fr | 1989 |
Plasma urate levels in mongolism.
Topics: Adolescent; Adult; Down Syndrome; Female; gamma-Globulins; Humans; Hypoxanthines; Male; Purines; Uri | 1969 |
Biochemical differentiation of trisomic Down's syndrome (mongolism) from that due to translocation.
Topics: Acid Phosphatase; Alkaline Phosphatase; Blood Cells; Blood Chemical Analysis; Calcium; Down Syndrome | 1965 |
Concentrations of uric acid in the sweat of control and mongoloid children.
Topics: Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Humans; In Vitro Techniques; Infant; Spec | 1966 |
Plasma uric acid in infants and children.
Topics: Adult; Congenital Hypothyroidism; Down Syndrome; Female; Humans; In Vitro Techniques; Infant; Infant | 1967 |
Hyperuricemia in mongolism.
Topics: Adolescent; Body Weight; Child; Child, Preschool; Down Syndrome; Humans; Metabolism, Inborn Errors; | 1967 |
A survey of serum uric acid levels in mentally retarded patients.
Topics: Adolescent; Adult; Aged; Athetosis; Central Nervous System Diseases; Down Syndrome; Female; Humans; | 1966 |
Clearance of uric acid, urea, and creatinine in Down's syndrome.
Topics: Adult; Blood Urea Nitrogen; Creatinine; Down Syndrome; Humans; Kidney Function Tests; Male; Metaboli | 1967 |
Hyperuricemia in Down's syndrome.
Topics: Adolescent; Adult; Age Factors; Aged; Chemistry, Clinical; Child; Child, Preschool; Chromosome Aberr | 1968 |
Ultraviolet-absorbing urinary components of mentally retarded children and schizophrenic adults.
Topics: Adolescent; Adult; Autoanalysis; Child; Chromatography, Ion Exchange; Chromatography, Paper; Down Sy | 1968 |
Metabolism of N15 labeled uric acid in Down's syndrome.
Topics: Adult; Body Height; Body Surface Area; Body Weight; Chemistry, Clinical; Down Syndrome; Humans; Inte | 1968 |
Neurologic aspects of typical and atypical Down's syndrome.
Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Down Syndrome; Electroencepha | 1968 |
Neurologic aspects of typical and atypical Down's syndrome.
Topics: Cataract; Chromosome Aberrations; Down Syndrome; Gait; Humans; Hydroxyindoleacetic Acid; Intelligenc | 1969 |
Alteration in metabolism of acetylsalicylic acid in children with Down's syndrome: decreased plasma binding and formation of salicyluric acid.
Topics: Aspirin; Child; Child, Preschool; Down Syndrome; Erythrocytes; Female; Humans; Male; Pharmacogenetic | 1970 |
Activities of hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase in erythrocytes from patients with Down's syndrome.
Topics: Adenine; Child; Chromosomes, Human, 21-22 and Y; Down Syndrome; Erythrocytes; Guanine; Humans; Hypox | 1972 |
Red cell size and uric acid in Down's syndrome.
Topics: Bone Marrow Cells; Child; Child, Preschool; Chromosome Aberrations; Cobalt Radioisotopes; Creatinine | 1973 |
[Gout and mongolism. Apropos of a case].
Topics: Adolescent; Down Syndrome; Gout; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Trisomy; | 1974 |
Correlation of bio-clinical parameters and intelligence in subjects with Down's syndrome and other retardates.
Topics: Adolescent; Adult; Alkaline Phosphatase; Blood Cell Count; Blood Proteins; Blood Sedimentation; Calc | 1974 |
Etiologic varieties of hyperuricemia and gout.
Topics: Acute Kidney Injury; Diabetic Ketoacidosis; Down Syndrome; Female; Gout; Hematologic Diseases; Human | 1974 |