uric acid has been researched along with Disease Models, Animal in 555 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Over the last decade, the biologic interference of uric acid with the cardiovascular (CV) system and the kidney has been intensively investigated, and several experimental studies in animal models and in vitro documented that hyperuricemia may trigger hypertension and incite endothelial dysfunction, vascular damage and renal disease." | 8.89 | Uric acid, hypertension, and cardiovascular and renal complications. ( Mallamaci, F; Zoccali, C, 2013) |
| "Uric acid has been suspected to be a risk factor for hypertension since the 1870s." | 8.88 | The role of uric acid in the pathogenesis of hypertension in the young. ( Feig, DI, 2012) |
| "Epidemiologic studies published during the past 3 years support the possible role of uric acid in the onset of essential hypertension." | 8.83 | Uric acid and hypertension. ( Feig, DI; Johnson, RJ; Kang, DH; Mazzali, M; Nakagawa, T, 2006) |
| "Mouse gouty arthritis model was established by injections of potassium oxonate (PO), monosodium urate (MSU) and pyroptosis suppressor disulfiram." | 8.12 | Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice. ( Hou, X; Liu, X; Tian, J; Wang, B; Xiang, L; Xie, B; Zhou, D, 2022) |
| "Insufficient renal urate excretion and/or overproduction of uric acid (UA) are the dominant causes of hyperuricemia." | 8.02 | Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase. ( Cao, Y; Chen, Y; Jiang, Y; Li, L; Li, Y; Lin, C; Pang, J; Tian, Y; Wu, T; Yang, Y; Zhao, Z; Zhou, P, 2021) |
| "Previous studies have suggested an association between uric acid (UA) and the severity of pulmonary arterial hypertension (PAH), but it is unknown whether UA contributes to disease pathogenesis." | 8.02 | Serum and pulmonary uric acid in pulmonary arterial hypertension. ( Akagi, S; Berrebeh, N; Boucly, A; Chaouat, A; Cottin, V; Cumont, A; Fadel, E; Guignabert, C; Huertas, A; Humbert, M; Jaïs, X; Jutant, EM; Le Vely, B; Mercier, O; Montani, D; Phan, C; Savale, L; Sitbon, O; Tamura, Y; Thuillet, R; Tromeur, C; Tu, L, 2021) |
| "Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues." | 8.02 | Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage. ( Cho, YY; Choi, N; Jang, JH; Kang, HC; Lee, HS; Lee, JY; Yang, G, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 8.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)." | 8.02 | Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021) |
| "The prospect of using the antioxidant dipeptide carnosine for the treatment of urate nephrolithiasis was evaluated." | 8.02 | Effect of Carnosine on the Course of Experimental Urate Nephrolithiasis. ( Azarova, OV; Bobrov, IP; Kalnitsky, AS; Makarova, OG; Mazko, ON; Zharikov, AY, 2021) |
| "To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain." | 8.02 | Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021) |
| "Berberine (BBR) is an active component of Phellodendri Cortex (PC), which is a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) for hundreds of years." | 8.02 | Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model. ( Chen, J; Huang, Z; Li, Q; Li, Y; Liu, D; Su, Z; Xie, J; Zeng, H; Zheng, J, 2021) |
| "The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo." | 7.96 | Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. ( Hosoyamada, M; Kimura, Y; Kono, H; Onda, A; Tsukui, D; Yanagida, T, 2020) |
| "To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis." | 7.96 | Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020) |
| "We aimed to investigate resistin expression in penile tissue in the presence of insulin resistance (IR) and the effect of Boldine treatment on erectile functions in the metabolic syndrome (MetS) rat model." | 7.96 | The role of resistin on metabolic syndrome-induced erectile dysfunction and the possible therapeutic effect of Boldine. ( Atabey, N; Dayar, E; Demir, O; Durmus, N; Gidener, S; Kahraman, E; Kara, E; Yetik Anacak, G, 2020) |
| " The present study was undertaken to evaluate the therapeutic effects and the underlying mechanisms of polydatin on potassium oxonate-induced hyperuricemia in rats through metabonomic technology from a holistic view." | 7.96 | NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats. ( Gong, M; Han, B; Li, Z; Qiu, Y; Zou, Z, 2020) |
| "EATP lowered the serum uric acid level and increased the urine uric acid level through excretion, which is useful in the treatment of gout." | 7.91 | Therapeutic potential of ethyl acetate fraction of Tephrosia purpurea Linn. leaves in a rat model of gout. ( Nipate, SS; Yelmar, PS, 2019) |
| "01) effectiveness of A-MNPs in management of hyperuricemic nephrolithiasis was observed through estimating pH and uric acid levels in urine and serum samples of mice." | 7.91 | Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis. ( Bhatt, DC; Jindal, DK; Kandav, G, 2019) |
| "Uric acid is persistently high after HS and leads to the activation of caspases-8 and organ inflammation; these can be prevented by an intervention to degrade UA." | 7.91 | Caspase-(8/3) activation and organ inflammation in a rat model of resuscitated hemorrhagic shock: A role for uric acid. ( Baril, F; Bouchard, C; Brochiero, E; Cardinal, AM; Charbonney, E; Dunberry-Poissant, S; Gilbert, K; Khazoom, F; Rousseau, G; Vega, MA, 2019) |
| "Gouty arthritis is an inflammatory disease that is triggered by abnormal uric acid metabolism, which is usually attributed to obesity, a risk factor of hyperuricemia and gout attack." | 7.91 | Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout. ( Fu, S; Liang, M; Lv, L; Wan, W; Xuan, D; Xue, Y; Yang, J; Yu, Y; Zhu, X; Zou, H, 2019) |
| " The RSGE treatment dose-dependently reduced PO- and MSU-induced paw edema, serum TNF-α, IL-1β, IL-6, IL-12, uric acid, and BUN, while significantly elevated serum IL-10, urinary uric acid and creatinine levels as compared with the respective values in the hyperuricemic and gouty mice group (vehicle group)." | 7.91 | Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice. ( Chang, Y; Liang, C; Liang, G; Nie, Y; Xiao, D; Zeng, S; Zhan, S; Zheng, Q; Zheng, X, 2019) |
| "Allopurinol is the first-line medication for hyperuricemia treatment." | 7.91 | Highly Acylated Anthocyanins from Purple Sweet Potato ( Ipomoea batatas L.) Alleviate Hyperuricemia and Kidney Inflammation in Hyperuricemic Mice: Possible Attenuation Effects on Allopurinol. ( Wang, Y; Yang, Y; Zhang, JL; Zhang, ZC; Zhou, Q, 2019) |
| " We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation." | 7.91 | Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis. ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Park, YB; Yang, G, 2019) |
| "After oral administration of Dioscin in potassium oxonate (PO) induced hyperuricemia rats and adenine-PO induced hyperuricemia mice models, serum uric acid and creatinine levels, clearance of uric acid and creatinine, fractional excretion of uric acid, and renal pathological lesions were determined were used to evaluate the antihyperuricemic effects." | 7.88 | Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia. ( Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y, 2018) |
| "The aetiology of gout is closely linked to the deposition of monosodium uric acid (MSU) crystals and the consequent activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome." | 7.88 | Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation. ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Yang, G; Yeon, SH, 2018) |
| "The present study suggests that luteolin and luteolin-4'-O-glucoside could be developed as therapeutics for treating hyperuricemia and gouty arthritis." | 7.88 | Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models. ( Hu, YJ; Liang, WQ; Lin, Y; Liu, PG; Pu, JB; Xu, P; Zhang, HJ; Zhou, J, 2018) |
| "Fraxini Cortex (also known as Qinpi, QP) has been used for the treatment of hyperuricemia with a significant difference on efficacy of QP from different regions." | 7.88 | Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9. ( Feng, L; Han, L; Jia, X; Li, C; Li, Z; Liu, J; Qiao, X; Song, J; Tan, X; Wang, G; Yuan, X; Zhang, X; Zhou, Y, 2018) |
| "Preclinical and clinical studies support a promising, albeit not definitive, neuroprotective effect of emergent uric acid (UA) administration in ischemic stroke." | 7.88 | Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats. ( Aliena-Valero, A; Burguete, MC; Castelló-Ruiz, M; Chamorro, Á; Hervás, D; Jover-Mengual, T; Leira, EC; López-Morales, MA; Salom, JB; Torregrosa, G, 2018) |
| "The model consisted of heat stress exposure (1 h, 37°C) plus rhabdomyolysis (R) induced by repetitive IM injections of glycerol (7." | 7.88 | Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate. ( Blas-Marron, MG; García-Arroyo, FE; Glaser, J; Gonzaga, G; Johnson, RJ; Madero, M; Muñoz-Jimenez, I; Osorio-Alonso, H; Roncal-Jiménez, CA; Sánchez-Lozada, LG; Silverio, O; Tapia, E; Weiss, I, 2018) |
| " With this in mind, the present study was designed to assess the antiurolithic effect of olive oil in a mouse model of ethylene glycol (EG)-induced urolithiasis." | 7.85 | Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis. ( Alenzi, M; Rahiman, S; Tantry, BA, 2017) |
| "Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders." | 7.85 | Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia. ( Choi, CW; Choi, Y; Hong, SS; Hyun, JM; Kim, JK; Kim, P; Kim, WJ; Kwon, JG; Lee, JK; Lee, JS; Park, K; Seo, C; Song, MJ; Sung, H, 2017) |
| " pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia." | 7.85 | Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. ( Hu, YJ; Jiang, Y; Lin, Y; Pan, HH; Song, XJ; Zhang, HJ, 2017) |
| "Potassium oxonate, a selectively competitive uricase inhibitor, produced hyperuricemia (HUA) in rodents in a previous study." | 7.85 | Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis). ( Li, ZL; Ma, KL; Tang, DH; Wang, CY; Ye, YS; Zheng, H, 2017) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 7.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| "The anti-inflammatory effect of morin, a dietary bioflavanol was explored on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis." | 7.83 | Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators. ( Dhanasekar, C; Rasool, M, 2016) |
| "The present study investigated the role of N-methyl-d-aspartate (NMDA) receptors in curcumin-mediated renoprotection against ischemia reperfusion (I/R)-induced acute kidney injury (AKI) in rats." | 7.83 | Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats. ( Kaur, A; Kaur, T; Pal Singh, A; Pathak, D; Singh Buttar, H; Singh, B, 2016) |
| "Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome." | 7.83 | Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout. ( Choi, JY; Jeong, S; Jung, Y; Kim, ND; Lee, HE; Lee, JY; Park, HH; Yang, G, 2016) |
| "In this study, we investigated the effects of a soft coral-derived anti-inflammatory compound, lemnalol, on mast cell (MC) function and osteoclast activity in rats with monosodium urate (MSU) crystal-induced gouty arthritis." | 7.81 | Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model. ( Duh, CY; Huang, SY; Jean, YH; Lee, HP; Lin, SC; Lin, YY; Wang, HM; Wen, ZH; Wu, SF, 2015) |
| "The combination of sodium alginate and resveratrol has better effect over colchicines in treating MSU-induced acute gouty arthritis." | 7.81 | Effect of sodium alginate addition to resveratrol on acute gouty arthritis. ( Chen, Y; Jiang, M; Ren, D; Wang, P; Wang, R; Wang, YG, 2015) |
| " Allopurinol is a commonly used medication to treat hyperuricemia and its complications." | 7.81 | Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice. ( Anderson, S; He, Y; Hou, PY; Mi, C; Wang, SQ; Wu, XH; Yu, F; Zhang, J; Zhang, YW, 2015) |
| "To investigate the mechanisms underlying the therapeutic effects of losartan on hyperuricemia-induced aortic atherosclerosis, in an experimental rabbit model." | 7.81 | Losartan alleviates hyperuricemia-induced atherosclerosis in a rabbit model. ( Ding, Y; Li, N; Miao, P; Zheng, H, 2015) |
| "These results indicated that quercetin exerted a strong anti-inflammatory effect that may be useful for the treatment of acute gouty arthritis." | 7.78 | Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. ( Chen, J; Huang, J; Li, S; Sun, W; Tao, Y; Wang, S; Zhu, M, 2012) |
| "In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin." | 7.77 | A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis. ( Nagar, S; Rasool, M; Sabina, EP, 2011) |
| "The aim of this study was to evaluate urinary uric acid (UA) and lipid peroxidation levels, plasma myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and serum UA in neonatal rats subjected to hypoxia-ischemia neonatal HI model." | 7.77 | Assessment of uric acid and lipid peroxidation in serum and urine after hypoxia-ischemia neonatal in rats. ( Kaefer, M; Moresco, RN; Moretto, MB; Pimentel, VC; Pinheiro, FV, 2011) |
| "Experiments were performed in freshly harvested aortas from untreated animals and rats fed with oxonic acid (hyperuricemia), and compared to hyperuricemic rats treated with either allopurinol, benzbromarone or arginine." | 7.77 | Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats. ( Chernichovski, T; Engel, A; Grupper, A; Hillel, O; Schwartz, D; Schwartz, IF, 2011) |
| " Previous studies using uric acid-lowering drugs in normouricemic animals are not suitable to answer the effect of hyperuricemia on ventricular remodeling after myocardial infarction." | 7.77 | Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia. ( Chen, CC; Hsu, YJ; Lee, TM, 2011) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 7.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| " This study was designed to evaluate the protective effect of gallic acid on cardiac marker enzymes, troponin-T, LDH-isoenzyme pattern, lipid peroxidation products and antioxidant status in isoproterenol (ISO)-induced myocardial infarction in male Wistar rats." | 7.75 | Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. ( Prince, PS; Priscilla, DH, 2009) |
| "To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved." | 7.75 | [Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009) |
| "As oxonic acid diet increased plasma renin activity, plasma aldosterone, and urine K to Na ratio, these changes may play a significant role in the harmful cardiovascular actions of hyperuricemia." | 7.74 | Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. ( Eräranta, A; Kööbi, P; Kurra, V; Lakkisto, P; Mustonen, JT; Niemelä, OJ; Pörsti, IH; Tahvanainen, AM; Tikkanen, I; Vehmas, TI, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 7.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| "Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues." | 7.73 | Gout-associated uric acid crystals activate the NALP3 inflammasome. ( Martinon, F; Mayor, A; Pétrilli, V; Tardivel, A; Tschopp, J, 2006) |
| "The aim of this study was to test the effect of L: -arginine methyl ester (L-Arg) on indices of free radical involvement in a rat model of experimental nephrocalcinosis." | 7.73 | The effect of L-arginine methyl ester on indices of free radical involvement in a rat model of experimental nephrocalcinosis. ( Buyukbayram, H; Ozturk, H; Yagmur, Y, 2006) |
| "To detect the effect of sepsis on renal function and corresponding enzymes in mice, and to explore the role of leptin in acute inflammation." | 7.73 | [Leptin protects sepsis-induced renal injury and research for its mechanism]. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2006) |
| "Colitis reduces the blood and tissue levels of adenosine deaminase and adenylate deaminase." | 7.71 | Blood purine and energy status in rats with colitis. ( Al-Awadi, FM; Khan, I, 2001) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 7.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "The potential antinociceptive effects of the S(+)- and R(-)-enantiomers of flurbiprofen (SFB and RFB, respectively) were investigated when given intravenously to rats using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 7.70 | Analysis of antinociceptive effects of flurbiprofen enantiomers in a rat model of arthritic pain. ( Cabré, F; Díaz, MI; Domínguez, AM; García, ML; Hernández, GP; López-Muñoz, FJ; Mauleón, D; Ventura, R, 2000) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 7.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "The content of uric acid was measured in the blood of patients suffering from retinitis pigmentosa, as well as in the blood, retina, brain, liver and urine of rats with inherited retinal degeneration in the course of postnatal development." | 7.66 | [Changes in the blood uric acid levels in patients with retinitis pigmentosa and in rats with hereditary retinal degeneration]. ( Chusova, GG; Eliseeva, RF; Ostapenko, IA; Shabanova, ME, 1982) |
| "Uric acid has been identified as an endogenous adjuvant that drives immune responses in the absence of microbial stimulation." | 6.47 | The role of uric acid as an endogenous danger signal in immunity and inflammation. ( Ghaemi-Oskouie, F; Shi, Y, 2011) |
| "Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system." | 6.44 | Uric acid: bystander or culprit in hypertension and progressive renal disease? ( Menè, P; Punzo, G, 2008) |
| "Gout is a painful form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints." | 5.72 | The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model. ( Aganetti, M; Amaral, FA; Braga, AD; de Faria, AMC; de Oliveira, VLS; Galvão, I; Georgel, P; Martins, VD; Mastrippolito, D; Mendes, V; Muller, S; Rocha, V; Talamini, L; Verdot, C; Vieira, AT, 2022) |
| " However, BBR exhibits low bioavailability due to its extensive metabolism and limited absorption." | 5.62 | Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. ( Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q, 2021) |
| "Secondary brain injury following hemorrhagic shock (HS) is a frequent complication in patients, even in the absence of direct brain trauma, leading to behavioral changes and more specifically anxiety and depression." | 5.62 | Targeting Uric Acid Prevents Brain Injury and Anxiety in a Rat Model of Hemorrhagic Shock. ( Bernard, F; Beyrouthy, J; Bouchard, C; Brochu, B; Charbonney, E; Gagné, MA; Gilbert, K; Khazoom, F; L'Ecuyer, S; Liu, C; Rousseau, G, 2021) |
| "Allopurinol treatment significantly reduced hepatic steatosis, epididymal fat, serum UA, HOMA-IR, hepatic enzyme levels, and cholesterol in the OLETF-HFrD-Allo group." | 5.62 | Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. ( Ahn, KJ; Cho, IJ; Chung, HY; Hwang, YC; Jeong, IK; Jeong, SW; Lee, SH; Lim, SJ; Moon, JY; Oh, DH; Yoo, J, 2021) |
| "Hyperuricemia is an important risk factor of chronic kidney disease, metabolic syndrome and cardiovascular disease." | 5.56 | The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine. ( Bao, R; Chen, Q; Liu, L; Liu, M; Wang, D; Wang, T; Wen, S; Yu, H; Zhang, Y, 2020) |
| "Ginsenoside Rb1 (GsRb1) is the best constituent of ginseng and although it shows clinical efficacy as an antineoplastic, antioxidative and antirheumatic agent, its oral bioavailability is poor due to its limited solubility." | 5.56 | Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals. ( Liu, Y; Ye, Q; Zhou, W; Zhu, H, 2020) |
| "Esculetin is a candidate urate-lowering drug with renoprotective activity and the ability to inhibit XO, promote excretion of UA, protect oxidative stress injury, and reduce renal fibrosis." | 5.56 | Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis. ( Huang, B; Kong, W; Meng, J; Wang, L; Wang, Y; Xie, Z; Yang, B; Zhang, T; Zhou, H, 2020) |
| "Preventing and treating renal fibrosis was an optimal treatment for hyperuricemia-induced kidney diseases." | 5.51 | Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy. ( Feng, Y; Fu, P; Guo, F; Li, L; Liu, J; Ma, L; Pan, J; Shi, M, 2019) |
| "Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR." | 5.48 | Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model. ( Cheng, W; Li, J; Li, W; Sun, B; Wu, J; Xie, J; Zhang, Q, 2018) |
| "After establishing middle cerebral artery occlusion of male rats with suture method, damage and increase of ROS production in brain tissue could be seen, and after adding suitable concentration of uric acid, the degree of brain damage and ROS production was reduced." | 5.46 | Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury. ( Lin, SP; Yang, N; Zhang, B; Zhang, F, 2017) |
| "Gout is a painful disorder which does not have an efficient delivery system for its treatment." | 5.46 | Oral delivery of allopurinol niosomes in treatment of gout in animal model. ( Kaithwas, G; Kanoujia, J; Parashar, P; Saraf, SA; Singh, N; Tripathi, CB, 2017) |
| "Gouty arthritis is characterized by inflammation induced by monosodium urate (MSU) crystal deposition, which is resulted by an increase of serum urate concentration." | 5.43 | The effect of resveratrol on the recurrent attacks of gouty arthritis. ( Chen, H; Liu, Q; Qiu, J; Wang, Y; Xue, Y; Zheng, S; Zhu, H; Zhu, X; Zou, H, 2016) |
| "Gout is a metabolic disorder associated with hyperuricemia resulting in the deposition of monosodium urate (MSU) crystals in joints and tissues." | 5.40 | Study on the anti-gout activity of chlorogenic acid: improvement on hyperuricemia and gouty inflammation. ( Cao, L; Ding, G; Guo, CR; Huang, WZ; Meng, ZQ; Tang, ZH; Wang, KD; Wang, ZZ; Xiao, W; Yan, YX; Yang, ZL, 2014) |
| "Astilbin is a flavonoid compound isolated from the rhizome of Smilax china L." | 5.37 | Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. ( Chen, L; Lan, Z; Li, F; Li, P; Yang, Z; Zhang, C; Zhang, X; Zhou, Y, 2011) |
| "Gout is an acute rheumatic disorder that occurs in connection with the deposition of monosodium urate (MSU) crystals in the joints." | 5.30 | Altered arachidonic acid metabolism in urate crystal induced inflammation. ( Duffin, KL; Gregory, SA; Isakson, PC; Margalit, A; Shaffer, AF, 1997) |
| " The main pathogens are crystals of monosodium urate (MSU), responsible for the gout, calcium pyrophosphate (CPP), which deposits also in various clinical forms of arthopathies, and basic calcium phosphate associated with osteoarthritis." | 4.90 | Pain and microcrystalline arthritis. ( Frallonardo, P; Lorenzin, MG; Oliviero, F; Ortolan, A; Punzi, L; Ramonda, R; Scanu, A, 2014) |
| "Over the last decade, the biologic interference of uric acid with the cardiovascular (CV) system and the kidney has been intensively investigated, and several experimental studies in animal models and in vitro documented that hyperuricemia may trigger hypertension and incite endothelial dysfunction, vascular damage and renal disease." | 4.89 | Uric acid, hypertension, and cardiovascular and renal complications. ( Mallamaci, F; Zoccali, C, 2013) |
| "Uric acid has been suspected to be a risk factor for hypertension since the 1870s." | 4.88 | The role of uric acid in the pathogenesis of hypertension in the young. ( Feig, DI, 2012) |
| " Fructose induces systemic hypertension through several mechanisms mainly associated with deleterious effects on target organs (kidney, endothelium, heart) exerted by the byproducts of its metabolism, such as uric acid." | 4.87 | Dietary fructose and hypertension. ( Jalal, D; Johnson, RJ; Madero, M; Perez-Pozo, SE; Sánchez-Lozada, LG, 2011) |
| "Elevated serum uric acid is a marker for decreased renal function, may have a mechanistic role in the incidence and progression of renal functional decline and likely has a causal role in hypertension and vascular disease." | 4.85 | Uric acid: a novel mediator and marker of risk in chronic kidney disease? ( Feig, DI, 2009) |
| "Epidemiologic studies published during the past 3 years support the possible role of uric acid in the onset of essential hypertension." | 4.83 | Uric acid and hypertension. ( Feig, DI; Johnson, RJ; Kang, DH; Mazzali, M; Nakagawa, T, 2006) |
| " A murine model of angiotensin II-induced AAA was used to assess the effects of hyperuricemia on AAA growth in vivo, and human aortic smooth muscle cells (HASMCs) were used to study the pathways involved in these effects in vitro." | 4.31 | Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway. ( Huang, PH; Lin, SJ; Tsai, HY; Tsai, SH; Wang, JC, 2023) |
| "This study uncovered an important and previously unrecognized role of hyperuricemia in mediating the pathogenesis of TAAD, and uric acid-lowering drug may represent a promising therapeutic approach for TAAD." | 4.31 | Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice. ( Cai, Z; Dai, R; Fu, Y; Gong, Z; Kong, W; Li, W; Li, Z; Luo, C; Shen, Y; Wang, J; Wu, H; Yang, L; Yu, F; Zhang, T; Zhang, X; Zhao, H; Zhao, Y; Zhu, J, 2023) |
| "The anti-hyperuricemic bioactivity of the non-alkaloids fraction and compounds were evaluated with potassium oxonate (PO) induced hyperuricemia mice model in vivo, and monosodium urate (MSU) induced human renal tubular epithelial cells (HK-2) was selected to test in vitro, respectively, with benzobromarone as the positive control." | 4.12 | Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro. ( Hu, BY; Luo, XD; Ma, DY; Xiang, ML; Zhao, LX; Zhao, YL, 2022) |
| "Mouse gouty arthritis model was established by injections of potassium oxonate (PO), monosodium urate (MSU) and pyroptosis suppressor disulfiram." | 4.12 | Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice. ( Hou, X; Liu, X; Tian, J; Wang, B; Xiang, L; Xie, B; Zhou, D, 2022) |
| "Treatment with STAT3 inhibitor S3I-201 improved renal dysfunction, reduced serum uric acid level, and delayed the progression of kidney fibrosis." | 4.02 | Pharmacologic inhibiting STAT3 delays the progression of kidney fibrosis in hyperuricemia-induced chronic kidney disease. ( Fu, P; Guo, F; Ma, L; Pan, J; Shi, M, 2021) |
| "Hyperuricemia is a metabolic condition closely linked to xanthine oxidase (XOD) function, which is involved in the production of uric acid (UA)." | 4.02 | Isorhamnetin, the xanthine oxidase inhibitor from ( Fang, L; Song, D; Su, X; Wang, F; Zhao, X; Zou, F, 2021) |
| " In addition, the present results suggest that melatonin supplementation attenuates adipose-hepatic metabolic dysfunction, accompanying obesity by suppression of oxidative stress/inflammation-dependent mechanism and increasing circulating obestatin." | 4.02 | Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model. ( Akintayo, CO; Atuma, CL; Aturamu, A; Badejogbin, OC; Mahmud, H; Obayemi, MJ; Olaniyi, KS; Oniyide, AA; Saidi, AO, 2021) |
| " However, the mechanism underlying high levels of uric acid inducing gouty arthritis has not been clarified." | 4.02 | Matrix Metalloproteinase-3 induces proteoglycan degradation in gouty arthritis model. ( Chen, AS; Jiang, JQ; Liang, T; Liang, XL; Liu, J; Shi, L; Wu, XW; Yang, F; Yuan, DP; Zhu, FF, 2021) |
| "Insufficient renal urate excretion and/or overproduction of uric acid (UA) are the dominant causes of hyperuricemia." | 4.02 | Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase. ( Cao, Y; Chen, Y; Jiang, Y; Li, L; Li, Y; Lin, C; Pang, J; Tian, Y; Wu, T; Yang, Y; Zhao, Z; Zhou, P, 2021) |
| "High levels of serum uric acid is closely associated with atrial fibrillation (AF); nonetheless, the detailed mechanisms remain unknown." | 4.02 | Increased Susceptibility of Atrial Fibrillation Induced by Hyperuricemia in Rats: Mechanisms and Implications. ( Li, Y; Liang, D; Liang, Z; Liu, H; Liu, Y; Su, M; Sun, L; Wang, D; Wei, Y; Yin, S; Zhang, G; Zhang, S; Zhao, J, 2021) |
| "Hyperuricemia is defined by the European Rheumatology Society as a uric acid level greater than 6 mg/dl (60 mg/l or 360 μmol/l)." | 4.02 | Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance. ( Affes, H; Charfi, S; Dhouibi, R; Hammami, S; Jamoussi, K; Ksouda, K; Marekchi, R; Moalla, D; Sahnoun, Z; Salem, MB; Zeghal, KM, 2021) |
| "Previous studies have suggested an association between uric acid (UA) and the severity of pulmonary arterial hypertension (PAH), but it is unknown whether UA contributes to disease pathogenesis." | 4.02 | Serum and pulmonary uric acid in pulmonary arterial hypertension. ( Akagi, S; Berrebeh, N; Boucly, A; Chaouat, A; Cottin, V; Cumont, A; Fadel, E; Guignabert, C; Huertas, A; Humbert, M; Jaïs, X; Jutant, EM; Le Vely, B; Mercier, O; Montani, D; Phan, C; Savale, L; Sitbon, O; Tamura, Y; Thuillet, R; Tromeur, C; Tu, L, 2021) |
| "Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues." | 4.02 | Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage. ( Cho, YY; Choi, N; Jang, JH; Kang, HC; Lee, HS; Lee, JY; Yang, G, 2021) |
| "The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms." | 4.02 | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. ( Cao, L; Xiao, WZ; Zhao, L; Zhu, XX; Zou, HJ, 2021) |
| " The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)." | 4.02 | Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021) |
| "The prospect of using the antioxidant dipeptide carnosine for the treatment of urate nephrolithiasis was evaluated." | 4.02 | Effect of Carnosine on the Course of Experimental Urate Nephrolithiasis. ( Azarova, OV; Bobrov, IP; Kalnitsky, AS; Makarova, OG; Mazko, ON; Zharikov, AY, 2021) |
| "To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain." | 4.02 | Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021) |
| "Berberine (BBR) is an active component of Phellodendri Cortex (PC), which is a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) for hundreds of years." | 4.02 | Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model. ( Chen, J; Huang, Z; Li, Q; Li, Y; Liu, D; Su, Z; Xie, J; Zeng, H; Zheng, J, 2021) |
| "The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo." | 3.96 | Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. ( Hosoyamada, M; Kimura, Y; Kono, H; Onda, A; Tsukui, D; Yanagida, T, 2020) |
| "To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis." | 3.96 | Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020) |
| "We aimed to investigate resistin expression in penile tissue in the presence of insulin resistance (IR) and the effect of Boldine treatment on erectile functions in the metabolic syndrome (MetS) rat model." | 3.96 | The role of resistin on metabolic syndrome-induced erectile dysfunction and the possible therapeutic effect of Boldine. ( Atabey, N; Dayar, E; Demir, O; Durmus, N; Gidener, S; Kahraman, E; Kara, E; Yetik Anacak, G, 2020) |
| " The present study was undertaken to evaluate the therapeutic effects and the underlying mechanisms of polydatin on potassium oxonate-induced hyperuricemia in rats through metabonomic technology from a holistic view." | 3.96 | NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats. ( Gong, M; Han, B; Li, Z; Qiu, Y; Zou, Z, 2020) |
| "Hyperuricemia (HUA) is a metabolic disease caused by the overproduction or underexcretion of uric acid (UA)." | 3.96 | Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats. ( Chen, SH; Chen, X; Ge, HZ; He, X; Jiang, ZT; Lei, SS; Li, B; Lv, GY; Su, J; Wang, HY; Yu, QX; Zheng, X, 2020) |
| "Compared to hyperuricaemia model or acute gout model, the compound gout model showed little advantages of elevating serum uric acid, causing foot swelling and gout inflammation, while it caused more severe serum inflammation and gut microbiota dysbiosis." | 3.96 | Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice. ( He, Z; Lin, X; Shao, T; Wang, M; Wen, C; Wen, X, 2020) |
| "Hyperuricemia is defined as a disease with high uric acid (UA) levels in the blood and a strong risk factor for gout." | 3.96 | Antihyperuricemic Effect of Urolithin A in Cultured Hepatocytes and Model Mice. ( Adachi, SI; Isoda, H; Komatsu, W; Kondo, S; Sasaki, K; Yagasaki, K; Yoshizawa, F, 2020) |
| "This study was designed to investigate the effects and underlying mechanisms of Astaxanthin (AST) on high-fructose-induced hyperuricemia (HUA) from the perspectives of the uric acid (UA) synthesis and excretion in rat models." | 3.96 | Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats. ( Chen, Y; Ding, G; Le, Y; Tang, Y; Yang, Z; Yu, F; Zheng, J; Zhou, X, 2020) |
| " The best studied of these diseases is gout, in which crystallization of uric acid in the form of monosodium urate (MSU) mainly in synovial fluid of the joints leads to sterile inflammation." | 3.96 | Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures. ( Alberts, A; Brand, K; Hoffmeister, L; Klingberg, A; Neumann, K; Pich, A; Wessig, AK, 2020) |
| "Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones." | 3.91 | A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. ( Beck, JN; Bose, N; Brackman, DJ; Chen, L; Chi, T; Giacomini, K; Hilsabeck, TA; Ho, S; Kahn, A; Kapahi, P; Killilea, DW; Lang, S; Sharma, A; Stoller, ML; Watson, MA; Wilson, KA, 2019) |
| " This study found that lemon water soluble extract (LET) can reduce uric acid levels in mice with potassium oxonate induced hyperuricemia." | 3.91 | Effect of lemon water soluble extract on hyperuricemia in a mouse model. ( Chen, L; Li, JX; Li, M; Ma, ZC; Wu, JL, 2019) |
| " Therefore, we compared the effects of different EDG extracts (water, 50% ethanol and 95% ethanol) on serum uric acid concentrations in the hyperuricemia model mouse." | 3.91 | Constituents and Anti-Hyperuricemia Mechanism of Traditional Chinese Herbal Formulae Erding Granule. ( Chen, H; Du, W; Feng, Y; Li, G; Yang, S; Yang, W; Zhang, C; Zhang, W, 2019) |
| "EATP lowered the serum uric acid level and increased the urine uric acid level through excretion, which is useful in the treatment of gout." | 3.91 | Therapeutic potential of ethyl acetate fraction of Tephrosia purpurea Linn. leaves in a rat model of gout. ( Nipate, SS; Yelmar, PS, 2019) |
| "01) effectiveness of A-MNPs in management of hyperuricemic nephrolithiasis was observed through estimating pH and uric acid levels in urine and serum samples of mice." | 3.91 | Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis. ( Bhatt, DC; Jindal, DK; Kandav, G, 2019) |
| "5% potassium oxonate (an uricase inhibitor) to induce hyperuricemia." | 3.91 | Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease. ( Dohgu, S; Fukae, J; Kataoka, Y; Koga, M; Matsumoto, J; Nakashima, A; Takata, F; Tsuboi, Y; Yamauchi, A, 2019) |
| "With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time." | 3.91 | A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity. ( Li, Q; Wang, F; Xing, C; Zhang, Y, 2019) |
| "Uric acid is persistently high after HS and leads to the activation of caspases-8 and organ inflammation; these can be prevented by an intervention to degrade UA." | 3.91 | Caspase-(8/3) activation and organ inflammation in a rat model of resuscitated hemorrhagic shock: A role for uric acid. ( Baril, F; Bouchard, C; Brochiero, E; Cardinal, AM; Charbonney, E; Dunberry-Poissant, S; Gilbert, K; Khazoom, F; Rousseau, G; Vega, MA, 2019) |
| "Gouty arthritis is an inflammatory disease that is triggered by abnormal uric acid metabolism, which is usually attributed to obesity, a risk factor of hyperuricemia and gout attack." | 3.91 | Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout. ( Fu, S; Liang, M; Lv, L; Wan, W; Xuan, D; Xue, Y; Yang, J; Yu, Y; Zhu, X; Zou, H, 2019) |
| " The RSGE treatment dose-dependently reduced PO- and MSU-induced paw edema, serum TNF-α, IL-1β, IL-6, IL-12, uric acid, and BUN, while significantly elevated serum IL-10, urinary uric acid and creatinine levels as compared with the respective values in the hyperuricemic and gouty mice group (vehicle group)." | 3.91 | Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice. ( Chang, Y; Liang, C; Liang, G; Nie, Y; Xiao, D; Zeng, S; Zhan, S; Zheng, Q; Zheng, X, 2019) |
| "Allopurinol is the first-line medication for hyperuricemia treatment." | 3.91 | Highly Acylated Anthocyanins from Purple Sweet Potato ( Ipomoea batatas L.) Alleviate Hyperuricemia and Kidney Inflammation in Hyperuricemic Mice: Possible Attenuation Effects on Allopurinol. ( Wang, Y; Yang, Y; Zhang, JL; Zhang, ZC; Zhou, Q, 2019) |
| " We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation." | 3.91 | Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis. ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Park, YB; Yang, G, 2019) |
| "The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia." | 3.88 | Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders. ( Cheng, X; Cui, L; Hou, X; Jia, Z; Li, C; Li, X; Liu, Z; Lu, J; Ma, L; Mi, QS; Ren, W; Sun, R; Tian, Z; Wang, C; Wang, X; Xin, Y; Yuan, X; Zhang, K, 2018) |
| "After oral administration of Dioscin in potassium oxonate (PO) induced hyperuricemia rats and adenine-PO induced hyperuricemia mice models, serum uric acid and creatinine levels, clearance of uric acid and creatinine, fractional excretion of uric acid, and renal pathological lesions were determined were used to evaluate the antihyperuricemic effects." | 3.88 | Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia. ( Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y, 2018) |
| "The aetiology of gout is closely linked to the deposition of monosodium uric acid (MSU) crystals and the consequent activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome." | 3.88 | Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation. ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Yang, G; Yeon, SH, 2018) |
| " Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated." | 3.88 | Uric acid upregulates the adiponectin‑adiponectin receptor 1 pathway in renal proximal tubule epithelial cells. ( Fu, C; Xiao, J; Yang, Q; Ye, Z, 2018) |
| "The present study suggests that luteolin and luteolin-4'-O-glucoside could be developed as therapeutics for treating hyperuricemia and gouty arthritis." | 3.88 | Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models. ( Hu, YJ; Liang, WQ; Lin, Y; Liu, PG; Pu, JB; Xu, P; Zhang, HJ; Zhou, J, 2018) |
| "Fraxini Cortex (also known as Qinpi, QP) has been used for the treatment of hyperuricemia with a significant difference on efficacy of QP from different regions." | 3.88 | Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9. ( Feng, L; Han, L; Jia, X; Li, C; Li, Z; Liu, J; Qiao, X; Song, J; Tan, X; Wang, G; Yuan, X; Zhang, X; Zhou, Y, 2018) |
| "Elevated circulating uric acid has been postulated to play an important pathophysiological role in estrogen-progestin combined oral contraceptive (COC)-induced hypertension and endothelial dysfunction." | 3.88 | Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin. ( Areola, ED; Badmus, OO; Kim, I; Michael, OS; Olatunji, LA; Omolekulo, TE, 2018) |
| "Preclinical and clinical studies support a promising, albeit not definitive, neuroprotective effect of emergent uric acid (UA) administration in ischemic stroke." | 3.88 | Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats. ( Aliena-Valero, A; Burguete, MC; Castelló-Ruiz, M; Chamorro, Á; Hervás, D; Jover-Mengual, T; Leira, EC; López-Morales, MA; Salom, JB; Torregrosa, G, 2018) |
| "The model consisted of heat stress exposure (1 h, 37°C) plus rhabdomyolysis (R) induced by repetitive IM injections of glycerol (7." | 3.88 | Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate. ( Blas-Marron, MG; García-Arroyo, FE; Glaser, J; Gonzaga, G; Johnson, RJ; Madero, M; Muñoz-Jimenez, I; Osorio-Alonso, H; Roncal-Jiménez, CA; Sánchez-Lozada, LG; Silverio, O; Tapia, E; Weiss, I, 2018) |
| "This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage." | 3.88 | Production Inhibition and Excretion Promotion of Urate by Fucoidan from ( Li, Y; Liu, H; Luo, P; Zhang, D, 2018) |
| " were tested in vivo using the model oxonate-induced hyperuricemia rats through determination of serum uric acid levels and inhibitory effects on xanthine oxidase (XO) in the rat liver." | 3.85 | Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content. ( Hoang, TK; Hwang, IH; Na, M; Nguyen, HA; Nguyen, MK; Nguyen, TD; Thuong, PT, 2017) |
| " affine extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition." | 3.85 | Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis. ( Cheng, L; Hu, YJ; Li, LN; Liang, WQ; Liu, PG; Pu, JB; Xu, P; Yang, QQ; Zhang, HJ; Zhang, YQ; Zhou, J, 2017) |
| " With this in mind, the present study was designed to assess the antiurolithic effect of olive oil in a mouse model of ethylene glycol (EG)-induced urolithiasis." | 3.85 | Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis. ( Alenzi, M; Rahiman, S; Tantry, BA, 2017) |
| "Resveratrol contributes to URAT1 expression, which is potentially useful in therapeutic strategies aimed at treating hyperuricemia." | 3.85 | Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats. ( Chang, LC; Lee, CT; Liu, CW; Wu, PF, 2017) |
| "Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders." | 3.85 | Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia. ( Choi, CW; Choi, Y; Hong, SS; Hyun, JM; Kim, JK; Kim, P; Kim, WJ; Kwon, JG; Lee, JK; Lee, JS; Park, K; Seo, C; Song, MJ; Sung, H, 2017) |
| "An elevated level of serum uric acid-hyperuricemia, is strongly associated with the development of gout and chronic kidney disease (CKD) which is often accompanied by a significantly reduced glomerular filtration rate (GFR)." | 3.85 | Oral uricase eliminates blood uric acid in the hyperuricemic pig model. ( Goncharova, K; Grujic, D; Lozinska, L; Mosiichuk, N; Pierzynowski, SG; Pieszka, M; Święch, E; Szczurek, P; Woliński, J; Yatsenko, T, 2017) |
| " pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia." | 3.85 | Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. ( Hu, YJ; Jiang, Y; Lin, Y; Pan, HH; Song, XJ; Zhang, HJ, 2017) |
| "Our results suggest that the active production of uric acid from human airway epithelial cells may be intrinsically altered in asthma and be further induced by pro-inflammatory cytokines." | 3.85 | Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells. ( Hansbro, PM; Hirota, JA; Hsu, AC; Huff, RD; Jones, B; Knight, DA; Nichol, KS; Wark, PAB, 2017) |
| "Potassium oxonate, a selectively competitive uricase inhibitor, produced hyperuricemia (HUA) in rodents in a previous study." | 3.85 | Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis). ( Li, ZL; Ma, KL; Tang, DH; Wang, CY; Ye, YS; Zheng, H, 2017) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 3.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| "The anti-inflammatory effect of morin, a dietary bioflavanol was explored on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis." | 3.83 | Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators. ( Dhanasekar, C; Rasool, M, 2016) |
| "The present study investigated the role of N-methyl-d-aspartate (NMDA) receptors in curcumin-mediated renoprotection against ischemia reperfusion (I/R)-induced acute kidney injury (AKI) in rats." | 3.83 | Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats. ( Kaur, A; Kaur, T; Pal Singh, A; Pathak, D; Singh Buttar, H; Singh, B, 2016) |
| "Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome." | 3.83 | Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout. ( Choi, JY; Jeong, S; Jung, Y; Kim, ND; Lee, HE; Lee, JY; Park, HH; Yang, G, 2016) |
| "The ability of XZCBF to facilitate the excretion of uric acid and to lower its level in the model group was mediated by the upregulation of miR-34a and the inhibition of URAT1 mRNA expression, which suggests that XZCBF could be an option for the treatment of hyperuricemia in mice." | 3.81 | Effects of Xie-Zhuo-Chu-Bi-Fang on miR-34a and URAT1 and their relationship in hyperuricemic mice. ( Li, J; Liu, YW; Liu, ZG; Sun, WF; Wu, XR; Zhang, XX; Zhu, MM, 2015) |
| "In this study, we investigated the effects of a soft coral-derived anti-inflammatory compound, lemnalol, on mast cell (MC) function and osteoclast activity in rats with monosodium urate (MSU) crystal-induced gouty arthritis." | 3.81 | Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model. ( Duh, CY; Huang, SY; Jean, YH; Lee, HP; Lin, SC; Lin, YY; Wang, HM; Wen, ZH; Wu, SF, 2015) |
| " We investigated the role of soluble uric acid in NLRP3 inflammasome activation in macrophages to demonstrate the effect of systemic hyperuricemia on progressive kidney damage in type 2 diabetes." | 3.81 | Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy. ( Choi, YW; Ihm, CG; Jeong, KH; Kim, DJ; Kim, SM; Kim, SY; Kim, YG; Lee, SH; Lee, TW; Moon, JY; Seo, JW; Won, KY, 2015) |
| "The hyperuricemia was induced by gavage of hypoxanthine and subcutaneous injection of potassium oxonate (model A) or subcutaneous injection of uric acid (model B) in ICR male mice." | 3.81 | [Hypouricemic effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma]. ( Fu, XC; Shan, HL; Shan, RP, 2015) |
| "The finding of this study showed that khat use was strongly associated with increment of levels of liver and kidney biomarkers, leucopenia, severe anemia, rise in level of inflammation biomarkers: C-reactive protein (CRP), uric acid (UA), increased monocyte-lymphocyte count ratio (MLCR), manifestation of cerebral malaria symptoms such as ataxia, paralysis and deviation of the head but with no pulmonary edema." | 3.81 | Effect of chronic khat (Catha edulis, Forsk) use on outcome of Plasmodium berghei ANKA infection in Swiss albino mice. ( Alemayehu, E; Ambelu, A; Ketema, T; Yohannes, M, 2015) |
| "The combination of sodium alginate and resveratrol has better effect over colchicines in treating MSU-induced acute gouty arthritis." | 3.81 | Effect of sodium alginate addition to resveratrol on acute gouty arthritis. ( Chen, Y; Jiang, M; Ren, D; Wang, P; Wang, R; Wang, YG, 2015) |
| " Allopurinol is a commonly used medication to treat hyperuricemia and its complications." | 3.81 | Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice. ( Anderson, S; He, Y; Hou, PY; Mi, C; Wang, SQ; Wu, XH; Yu, F; Zhang, J; Zhang, YW, 2015) |
| "We demonstrated that 3-nitrotyrosine and 4-hydroxy-2-nonenal levels in mouse brain were elevated from 1 h until 8 h after global brain ischemia for 14 min induced with the 3-vessel occlusion model; this result indicates that ischemia reperfusion injury generated oxidative stress." | 3.81 | The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice. ( Fuse, A; Kusano, T; Matsuda, Y; Okamoto, K; Suzuki, G; Yamaguchi, M; Yokota, H, 2015) |
| "Gout is an acute inflammatory disease characterised by the presence of uric acid crystals in the joint." | 3.81 | Oral treatment with Bifidobacterium longum 51A reduced inflammation in a murine experimental model of gout. ( Amaral, FA; Galvão, I; Martins, FS; Nicoli, JR; Teixeira, MM; Vieira, AT, 2015) |
| "This study evaluated the effects of crude drugs obtained from the silkworm in mice with oxonic acid-induced hyperuricemia using xanthine oxidase inhibitory activity and plasma uric acid levels." | 3.81 | [The Xanthine Oxidase Inhibitory Activity and Hypouricemic Effects of Crude Drugs Obtained from the Silkworm in Mice]. ( Minakuchi, N; Miyata, Y; Murakami, A; Sakazaki, F; Tanaka, R, 2015) |
| "To investigate the mechanisms underlying the therapeutic effects of losartan on hyperuricemia-induced aortic atherosclerosis, in an experimental rabbit model." | 3.81 | Losartan alleviates hyperuricemia-induced atherosclerosis in a rabbit model. ( Ding, Y; Li, N; Miao, P; Zheng, H, 2015) |
| " UOMVLs decrease serum uric acid levels in rats with hyperuricemia more effectively than UOX." | 3.81 | [The Pharmacokinetics and Pharmacodynamics of Intravenous Uricase Multivesicular Liposomes]. ( Deng, X; He, D; Xiong, HR; Zhang, JQ; Zhou, YL, 2015) |
| " oldhamii leaf extracts was investigated using potassium oxonate (PO)-induced acute hyperuricemia." | 3.81 | Antioxidative phytochemicals from Rhododendron oldhamii Maxim. leaf extracts reduce serum uric acid levels in potassium oxonate-induced hyperuricemic mice. ( Chiu, CC; Chuang, HL; Ho, ST; Huang, CC; Lin, CY; Lin, LC; Liu, YL; Tung, YT; Wu, JH, 2015) |
| " riparia in reducing serum uric acid levels in a potassium oxonate-induced hyperuricemia mouse model." | 3.80 | Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout. ( Anderson, S; Wu, XH; Yu, CH; Zhang, CF; Zhang, YW, 2014) |
| "The aim of this study was to investigate the effects of pravastatin and nebivolol in the atherosclerotic process including inflammation and oxidative stress in rat aorta." | 3.80 | The anti-inflammatory and antioxidant effects of pravastatin and nebivolol in rat aorta. ( Aktaş, SG; Atay, A; Çuhadar, S; Dursun, S; Köseoğlu, M, 2014) |
| "5% fat UHT milk diet or allopurinol therapy in rat experimental hyperuricemia." | 3.80 | Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia. ( Cvetkovic, T; Jevtovic, T; Jovanovic, A; Jovanovic, J; Kocic, G; Kocic, H; Sokolovic, D; Stojanovic, S; Veljkovic, A; Zivkovic, P, 2014) |
| "These results suggest that pallidifloside D possesses a potent uricosuric effect in hyperuricemic mice through decreasing renal mURAT1 and GLUT9, which contribute to the enhancement of uric acid excretion and attenuate hyperuricemia-induced renal dysfunction." | 3.80 | Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice. ( Ruan, JL; Wang, SQ; Wu, XH; Zhang, J; Zhang, YW, 2014) |
| "To study the effects of uric acid on cardiac lesions and its possible mechanism by establishing an early-stage CKD animal model with hyperuricemia." | 3.80 | Effects of uric acid on hearts of rats with chronic kidney disease. ( Bao, X; Wang, Y; Wei, C; Zhang, Q, 2014) |
| " d-1 ) to prepare the hyperuricemia model, and divided into normal, model, Allopurinol, LE high dosage, middle dosage and low dose (200, 100, 50 mg ." | 3.80 | [Regulatory effect of leonurus extracts on hyperuricemia in rats]. ( An, YT; Li, J; Wang, T; Wu, ZZ; Yan, M, 2014) |
| "Hyperuricemia mice model was established with uricase inhibitor (potassium oxonate) and uric acids in serum were observed." | 3.80 | [Anti-hyperuricemia effect and mechanism of polydatin in mice]. ( Jiang, H; Wu, G; Wu, HB, 2014) |
| "Hyperuricemia, excess of uric acid in the blood, is a clinical problem that causes gout and is also considered a risk factor for cardiovascular disease." | 3.79 | 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout. ( Chen, C; Lü, JM; Yao, Q, 2013) |
| "Treatment with Jianpihuashi Decoction for 30 days, the serum uric acid level of rats with hyperuricemia were significantly decreased (P < 0." | 3.79 | [Effect of jianpihuashi decoction on rats with hyperuricemia]. ( Chen, JW; Guo, J; Jiang, JM; Li, C; Xue, ZY; Zhou, LY; Zhou, Y, 2013) |
| "Hyperuricemia in mice was induced by intraperitoneally administering uric acid (250 mg/ kg)." | 3.79 | Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice. ( Chu, Z; Pan, Y; Wang, W; Yang, B, 2013) |
| " Blood urea nitrogen (BUN), serum creatinine (Scr), uric acid (UA) and proteinuria were evaluated." | 3.78 | Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model. ( He, J; Pei, X; Sun, S; Wang, C; Wang, Y; Wu, J; Yu, M; Zhao, W; Zhu, B, 2012) |
| "These results indicated that quercetin exerted a strong anti-inflammatory effect that may be useful for the treatment of acute gouty arthritis." | 3.78 | Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. ( Chen, J; Huang, J; Li, S; Sun, W; Tao, Y; Wang, S; Zhu, M, 2012) |
| "These findings demonstrate that mangiferin has the potential to be developed as a new therapeutic agent for the treatment of hyperuricemia and gout." | 3.78 | Reducing effect of mangiferin on serum uric acid levels in mice. ( Gao, L; Li, L; Lin, H; Liu, X; Lu, W; Niu, Y, 2012) |
| "Over the past century, uric acid has been considered a possible risk factor for hypertension and cardiovascular disease." | 3.78 | Hyperuricemia and hypertension. ( Feig, DI, 2012) |
| "In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin." | 3.77 | A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis. ( Nagar, S; Rasool, M; Sabina, EP, 2011) |
| "The aim of this study was to evaluate urinary uric acid (UA) and lipid peroxidation levels, plasma myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and serum UA in neonatal rats subjected to hypoxia-ischemia neonatal HI model." | 3.77 | Assessment of uric acid and lipid peroxidation in serum and urine after hypoxia-ischemia neonatal in rats. ( Kaefer, M; Moresco, RN; Moretto, MB; Pimentel, VC; Pinheiro, FV, 2011) |
| "Experiments were performed in freshly harvested aortas from untreated animals and rats fed with oxonic acid (hyperuricemia), and compared to hyperuricemic rats treated with either allopurinol, benzbromarone or arginine." | 3.77 | Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats. ( Chernichovski, T; Engel, A; Grupper, A; Hillel, O; Schwartz, D; Schwartz, IF, 2011) |
| "Xanthine oxidase is a key enzyme that catalyses hypoxanthine and xanthine to uric acid and the overproduction of uric acid will lead to hyperuricemia which is an important cause of gout." | 3.77 | 3,5,2',4'-Tetrahydroxychalcone, a new non-purine xanthine oxidase inhibitor. ( Fan, H; Li, L; Liu, J; Liu, X; Lu, W; Niu, Y; Sun, L; Zhu, H, 2011) |
| " Previous studies using uric acid-lowering drugs in normouricemic animals are not suitable to answer the effect of hyperuricemia on ventricular remodeling after myocardial infarction." | 3.77 | Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia. ( Chen, CC; Hsu, YJ; Lee, TM, 2011) |
| " Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals." | 3.77 | Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis. ( Kumar, BS; Kumar, RP; Palani, S; Raja, S; Selvaraj, R, 2011) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 3.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| " This has led to the hypothesis that uric acid may contribute to renal fibrosis and progressive renal disease." | 3.76 | Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells. ( Junwei, Y; Lei, J; Li, F; Mingxia, X; Ping, W; Ruoyun, T; Weichun, H; Xiaohua, W; Yang, Z, 2010) |
| "Diazepam-reduced experimental anxiety was paralleled by antinociceptive effects." | 3.76 | Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray. ( Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ, 2010) |
| " This study was designed to evaluate the protective effect of gallic acid on cardiac marker enzymes, troponin-T, LDH-isoenzyme pattern, lipid peroxidation products and antioxidant status in isoproterenol (ISO)-induced myocardial infarction in male Wistar rats." | 3.75 | Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. ( Prince, PS; Priscilla, DH, 2009) |
| " Rosiglitazone was also administered to demonstrate whether improved insulin sensitivity would prevent high-purine diet induced renal injury and gouty-like lesions." | 3.75 | Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions. ( Gu, J; Li, C; Li, Y; Meng, D; Miao, Z; Wang, B; Wang, CY; Wang, J; Wang, L; Xing, X; Yan, S; Yuan, Y; Zhang, S, 2009) |
| "To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved." | 3.75 | [Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009) |
| "Understanding how uric acid crystals provoke inflammation is crucial to improving our management of acute gout." | 3.74 | Gout in the spotlight. ( So, A, 2008) |
| "As oxonic acid diet increased plasma renin activity, plasma aldosterone, and urine K to Na ratio, these changes may play a significant role in the harmful cardiovascular actions of hyperuricemia." | 3.74 | Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. ( Eräranta, A; Kööbi, P; Kurra, V; Lakkisto, P; Mustonen, JT; Niemelä, OJ; Pörsti, IH; Tahvanainen, AM; Tikkanen, I; Vehmas, TI, 2008) |
| "In rats with hyperuricemia induced by 2% oxonic acid and 0." | 3.74 | Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia. ( Chen, K; Cui, WY; Liu, GS; Long, CL; Pan, ZY; Qin, XC; Wang, H; Zhang, YF, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 3.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| " We evaluated the hypouricemic effect of propolis from China on hyperuricemia induced by the uricase inhibitor, oxonic acid (500 mg/kg p." | 3.73 | [Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats]. ( Nishioka, N; Tsuji, T; Yoshizumi, K, 2005) |
| "To examine the ability of rofecoxib prophylaxis to blunt the effect of monosodium urate (MSU) crystal inflammation induced in the rat subcutaneous air pouch." | 3.73 | Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch. ( Chen, LX; Clayburne, G; Nalbant, S; Schumacher, HR; Sieck, MS, 2005) |
| "The effects of acacetin (1) and 4,5-O-dicaffeoylquinic acid methyl ester (2), compounds contained in the flowers of Chrysanthemum sinense SABINE, on the serum uric acid level were investigated using the rats pretreated with the uricase inhibitor potassium oxonate as an animal model for hyperuricemia." | 3.73 | Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats. ( Awale, S; Kadota, S; Matsumoto, K; Murakami, Y; Nguyen, MT; Shi, L; Tezuka, Y; Tran, QL; Ueda, JY; Zaidi, SF, 2005) |
| "Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues." | 3.73 | Gout-associated uric acid crystals activate the NALP3 inflammasome. ( Martinon, F; Mayor, A; Pétrilli, V; Tardivel, A; Tschopp, J, 2006) |
| "The aim of this study was to test the effect of L: -arginine methyl ester (L-Arg) on indices of free radical involvement in a rat model of experimental nephrocalcinosis." | 3.73 | The effect of L-arginine methyl ester on indices of free radical involvement in a rat model of experimental nephrocalcinosis. ( Buyukbayram, H; Ozturk, H; Yagmur, Y, 2006) |
| "To detect the effect of sepsis on renal function and corresponding enzymes in mice, and to explore the role of leptin in acute inflammation." | 3.73 | [Leptin protects sepsis-induced renal injury and research for its mechanism]. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2006) |
| " Progression of the chronic synovitis in zymosan-induced arthritis (ZYA) was associated with increased nitrite and nitrotyrosine (3-NT) levels in the joint exudates that paralleled a progressive loss of the GAG content." | 3.72 | Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis. ( Bezerra, MM; Brain, SD; da Rocha, FA; de Melo, LB; Greenacre, S; Jerônimo, SM; Keeble, J, 2004) |
| "The role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR model), a model of inflammatory and chronic pain similar to that observed in clinical gout." | 3.72 | Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat. ( Déciga-Campos, M; Díaz-Reval, MI; González-Trujano, ME; López-Muñoz, FJ; Ventura-Martínez, R, 2004) |
| "Humans have a non-sense codon inserted into the 5 prime end of the open reading frame of urate oxidase, and thus express an enzymatically inactive fragment of this enzyme; and consequently are unable to metabolize uric acid into allantoin and are prone to develop hyperuricemia and gout." | 3.71 | Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. ( Bomalaski, JS; Clark, MA; Ensor, CM; Holtsberg, FW, 2002) |
| "Colitis reduces the blood and tissue levels of adenosine deaminase and adenylate deaminase." | 3.71 | Blood purine and energy status in rats with colitis. ( Al-Awadi, FM; Khan, I, 2001) |
| "To investigate the involvement of oxidative tissue damage in the pathogenesis of murine cerebral malaria (CM), brain levels of protein carbonyls, 3,4-dihydroxyphenylalanine (DOPA), o-tyrosine, and dityrosine were measured during Plasmodium berghei ANKA (PbA) and P." | 3.70 | Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria? ( Bloomfield, G; Chaudhri, G; Dean, RT; Dinauer, MC; Fu, S; Hunt, NH; Sanni, LA; Stocker, R, 1999) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 3.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "The potential antinociceptive effects of the S(+)- and R(-)-enantiomers of flurbiprofen (SFB and RFB, respectively) were investigated when given intravenously to rats using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 3.70 | Analysis of antinociceptive effects of flurbiprofen enantiomers in a rat model of arthritic pain. ( Cabré, F; Díaz, MI; Domínguez, AM; García, ML; Hernández, GP; López-Muñoz, FJ; Mauleón, D; Ventura, R, 2000) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 3.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "The content of uric acid was measured in the blood of patients suffering from retinitis pigmentosa, as well as in the blood, retina, brain, liver and urine of rats with inherited retinal degeneration in the course of postnatal development." | 3.66 | [Changes in the blood uric acid levels in patients with retinitis pigmentosa and in rats with hereditary retinal degeneration]. ( Chusova, GG; Eliseeva, RF; Ostapenko, IA; Shabanova, ME, 1982) |
| "Patients with ESRD undergo frequent maintenance (haemo)dialysis treatment, and finally must receive a combined liver-kidney transplantation as the only curative treatment option available in PH Type 1." | 2.61 | Targeting kidney inflammation as a new therapy for primary hyperoxaluria? ( Hoppe, B; Kurts, C; Ludwig-Portugall, I; Martin-Higueras, C, 2019) |
| "Hyperphosphatemia is a major problem in these patients especially at advanced stages of CKD, and it is associated with cardiovascular and mineral complications in these patients." | 2.50 | [Pleiotropic effects of sevelamer: a model of intestinal tract chelating agent]. ( Maizel, J; Massy, ZA, 2014) |
| "Uric acid has been associated with renal disease, even though hyperuricemia may be a marker of or by itself be responsible for microvascular disease in diabetes." | 2.47 | Serum uric acid as a new player in the development of diabetic nephropathy. ( Hovind, P; Johnson, RJ; Parving, HH; Rossing, P, 2011) |
| "Uric acid has been identified as an endogenous adjuvant that drives immune responses in the absence of microbial stimulation." | 2.47 | The role of uric acid as an endogenous danger signal in immunity and inflammation. ( Ghaemi-Oskouie, F; Shi, Y, 2011) |
| "Gouty arthritis is a form of acute joint inflammation provoked by joint deposition of urate crystals." | 2.47 | Role of melanocortin receptors in the regulation of gouty inflammation. ( Montero-Melendez, T; Patel, HB; Perretti, M, 2011) |
| "Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease." | 2.46 | Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? ( Keenan, RT; Shah, A, 2010) |
| "An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation." | 2.46 | Mechanisms of inflammation in gout. ( Busso, N; So, A, 2010) |
| "Uric acid has previously been viewed as a benign solute in serum until it exceeds its saturation level." | 2.45 | The role of hyperuricemia in vascular disorders. ( Edwards, NL, 2009) |
| "Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system." | 2.44 | Uric acid: bystander or culprit in hypertension and progressive renal disease? ( Menè, P; Punzo, G, 2008) |
| " The ideal uricase inhibitor for induction of hyperuricemia would be one which is irreversible, noncompetitive, and relatively nontoxic, so that its activity would be independent of high levels of uric acid, and effective inhibition could be attained at low dosage levels." | 2.36 | Use of the uricase-inhibited rat as an animal model in toxicology. ( Nera, EA; Stavric, B, 1978) |
| "The underlying mechanism of muscle hyperalgesia associated with locally recruited neutrophils forming NETs due to increased tissue UA levels potentially plays a significant role in creating a vicious circle of muscle pain." | 1.72 | Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model. ( Aizawa, T; Chen, W; Fujita, R; Hagiwara, Y; Kanzaki, M; Li, Y; Ogawa, K; Suzuki, K; Takahashi, T; Tsuchiya, M; Yabe, Y; Yoshida, S, 2022) |
| "Gouty arthritis is an inflammatory disease induced by monosodium urate (MSU), and is closely related to the activation of inflammasomes." | 1.72 | Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF-κB and p62-Keap1 pathways. ( Li, Y; Liu, X; Tian, J; Wang, B; Xiang, L; Xie, B; Zhou, D, 2022) |
| "Gout is a painful form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints." | 1.72 | The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model. ( Aganetti, M; Amaral, FA; Braga, AD; de Faria, AMC; de Oliveira, VLS; Galvão, I; Georgel, P; Martins, VD; Mastrippolito, D; Mendes, V; Muller, S; Rocha, V; Talamini, L; Verdot, C; Vieira, AT, 2022) |
| "Uric acid (UA) has anti- and pro-inflammatory properties." | 1.72 | Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota. ( Akiyama, M; Hanawa, Y; Higashiyama, M; Hokari, R; Horiuchi, K; Inaba, K; Ito, S; Komoto, S; Kurihara, C; Mizoguchi, A; Nishii, S; Okada, Y; Shibuya, N; Sugihara, N; Takei, F; Tanemoto, R; Tomita, K; Wada, A; Watanabe, C, 2022) |
| " However, BBR exhibits low bioavailability due to its extensive metabolism and limited absorption." | 1.62 | Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. ( Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q, 2021) |
| "Both astrogliosis and microgliosis were observed in the hippocampus and white matter at postnatal day (PND)7 with IL-1Ra being protective." | 1.62 | Prenatal administration of IL-1Ra attenuate the neurodevelopmental impacts following non-pathogenic inflammation during pregnancy. ( Brien, ME; Girard, S; Hughes, K, 2021) |
| "In view of the current status of treatment of hyperuricemia, we evaluated the hypouricemic effects of ISO in vivo and in vitro, and explored the underlying mechanisms." | 1.62 | Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway. ( An, MF; Shen, C; Sheng, J; Sun, ZR; Wang, MY; Wang, XJ; Zhao, YL, 2021) |
| "Secondary brain injury following hemorrhagic shock (HS) is a frequent complication in patients, even in the absence of direct brain trauma, leading to behavioral changes and more specifically anxiety and depression." | 1.62 | Targeting Uric Acid Prevents Brain Injury and Anxiety in a Rat Model of Hemorrhagic Shock. ( Bernard, F; Beyrouthy, J; Bouchard, C; Brochu, B; Charbonney, E; Gagné, MA; Gilbert, K; Khazoom, F; L'Ecuyer, S; Liu, C; Rousseau, G, 2021) |
| "Gout is a common metabolic disease with growing burden, caused by monosodium urate (MSU) microcrystal deposition." | 1.62 | Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering. ( Ao, J; Chen, J; Hua, Y; Ji, M; Xu, H; Xue, Y; Yang, Y; Zhang, B; Zhu, X, 2021) |
| "Uric acid is a powerful antioxidant." | 1.62 | Detrimental effects of long-term elevated serum uric acid on cognitive function in rats. ( Gu, CW; Jia, H; Li, SJ; Li, TT; Liu, XR; Nie, ZC; Tang, Y; Tian, T; Xu, WD, 2021) |
| "Allopurinol treatment significantly reduced hepatic steatosis, epididymal fat, serum UA, HOMA-IR, hepatic enzyme levels, and cholesterol in the OLETF-HFrD-Allo group." | 1.62 | Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. ( Ahn, KJ; Cho, IJ; Chung, HY; Hwang, YC; Jeong, IK; Jeong, SW; Lee, SH; Lim, SJ; Moon, JY; Oh, DH; Yoo, J, 2021) |
| "Currently, the treatment of gout mainly includes two basic methods: reducing uric acid and alleviating inflammation." | 1.56 | Development of novel NLRP3-XOD dual inhibitors for the treatment of gout. ( Ha, EH; Hu, Q; Li, H; Li, Z; Pang, J; Tian, S; Wang, W; Zhou, M, 2020) |
| "The current treatment options for soft tissue injuries remain suboptimal and often result in delayed or incomplete recovery of damaged muscles." | 1.56 | Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury. ( Ho, CS; Hsu, YJ; Huang, CC; Kan, NW; Lee, MC, 2020) |
| "Gout is the typical feature of GAstrV infection in goslings." | 1.56 | Goose astrovirus infection affects uric acid production and excretion in goslings. ( Bao, E; Lv, Y; Wu, W; Xu, R, 2020) |
| "Hyperuricemia is a central risk factor for gout and increases the risk for other chronic diseases, including cardiometabolic disease, kidney disease, and hypertension." | 1.56 | High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout. ( Dai, S; Guo, Y; Hong, F; Li, L; Liu, G; Pan, S; Qiao, X; Wang, J; Xie, X; Xu, P; Xue, T; Zhai, Y; Zheng, A, 2020) |
| "Acute gouty arthritis is an auto-inflammatory disease caused by the deposition of monosodium urate (MSU) crystals in joints or tissues." | 1.56 | 1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol (PLAG) Mitigates Monosodium Urate (MSU)-Induced Acute Gouty Inflammation in BALB/c Mice. ( Jeong, J; Kim, JH; Kim, JW; Shin, SH; Sohn, KY; Yoon, SY, 2020) |
| "Hyperuricemia is an important risk factor of chronic kidney disease, metabolic syndrome and cardiovascular disease." | 1.56 | The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine. ( Bao, R; Chen, Q; Liu, L; Liu, M; Wang, D; Wang, T; Wen, S; Yu, H; Zhang, Y, 2020) |
| "Olsalazine sodium was screened from 3167 authorized small compounds/drugs, targeting xanthine oxidoreductase." | 1.56 | Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals. ( Gao, L; Li, H; Li, L; Li, Q; Lin, H; Niu, Y; Yang, P, 2020) |
| "Ginsenoside Rb1 (GsRb1) is the best constituent of ginseng and although it shows clinical efficacy as an antineoplastic, antioxidative and antirheumatic agent, its oral bioavailability is poor due to its limited solubility." | 1.56 | Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals. ( Liu, Y; Ye, Q; Zhou, W; Zhu, H, 2020) |
| "Esculetin is a candidate urate-lowering drug with renoprotective activity and the ability to inhibit XO, promote excretion of UA, protect oxidative stress injury, and reduce renal fibrosis." | 1.56 | Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis. ( Huang, B; Kong, W; Meng, J; Wang, L; Wang, Y; Xie, Z; Yang, B; Zhang, T; Zhou, H, 2020) |
| "Curcumin treatment markedly inhibited the degradation of IκBα, the activation of NF-κB signaling pathway, and the expression levels of the NF-κB downstream inflammatory genes such as IL-1β, IL-6, TNF-α, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages." | 1.51 | Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage. ( Chen, B; Li, H; Ou, G; Ren, L; Yang, X; Zeng, M, 2019) |
| " In this study, the main pharmacodynamics of different dosing methods and dosages of P-b4 was firstly investigated." | 1.51 | LC-MS Analysis of Serum for the Metabolomic Investigation of the Effects of Pulchinenoside b4 Administration in Monosodium Urate Crystal-Induced Gouty Arthritis Rat Model. ( Ding, R; Feng, Y; Liu, P; Lyu, S; OuYang, H; Rao, Y; Yang, S, 2019) |
| "Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy." | 1.51 | Blockage of macrophage migration inhibitory factor (MIF) suppressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling. ( Fu, X; Li, G; Liu, Q; Lou, Y; Mei, J; Niu, N; Qu, P; Sui, Z; Sun, J; Xu, M, 2019) |
| "Preventing and treating renal fibrosis was an optimal treatment for hyperuricemia-induced kidney diseases." | 1.51 | Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy. ( Feng, Y; Fu, P; Guo, F; Li, L; Liu, J; Ma, L; Pan, J; Shi, M, 2019) |
| "Gout is one of the most common metabolic disorders in human." | 1.51 | Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation. ( Chen, J; Duan, L; Rao, X; Razavi, M; Tao, Y; Wei, Y; Zhong, J, 2019) |
| "Uric acid could increase inflammatory cytokines and upregulate tissue RAS in rat adipocytes, which were both blocked with TLR2/4-siRNA infection." | 1.51 | TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid. ( Diao, B; Lin, X; Tang, F; Xu, J; Zhang, J, 2019) |
| "Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation." | 1.51 | Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation. ( He, YL; Mi, QS; Yang, QB; Zhang, QB; Zhou, JG, 2019) |
| "Obovatol was treated to macrophages with inflammasome triggers, and secretions of interleukin (IL)-1β, IL-18, and caspase-1 were measured as readouts of inflammasome activation." | 1.51 | Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation. ( Ahn, H; Han, BC; Jung, EM; Kang, SG; Kim, J; Kim, JC; Lee, GS; Lee, J; Lee, SH; Shin, H; Yang, H, 2019) |
| " The cellular mechanisms that lead to those outcomes require an increase in intracellular concentrations of uric acid inducing oxidative stress that then activates the synthesis and secretion of proinflammatory factors and vasoconstrictive substances, and diminishes the bioavailability of nitric oxide produced by eNOS." | 1.48 | The Pathophysiology of Uric Acid on Renal Diseases. ( Sánchez-Lozada, LG, 2018) |
| "Hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and kidney and cardiovascular diseases." | 1.48 | Renal Effects of Hyperuricemia. ( Méndez Landa, CE, 2018) |
| "Uric acid has a role in several physiological and pathophysiological processes." | 1.48 | Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats. ( Dobolyi, Á; Kovács, Z; Lakatos, RK, 2018) |
| "Gout is the most common inflammatory arthritis affecting men." | 1.48 | Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. ( Ashimbayeva, E; Astin, JW; Britto, D; Crosier, KE; Crosier, PS; Dalbeth, N; Hall, CJ; Harper, JL; Lawrence, LM; Lieschke, GJ; Pool, B; Sanderson, LE; van der Kroef, M, 2018) |
| "Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR." | 1.48 | Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model. ( Cheng, W; Li, J; Li, W; Sun, B; Wu, J; Xie, J; Zhang, Q, 2018) |
| "Quercetin-treated model rats had reduced serum levels of parathyroid hormone (PTH), inorganic phosphate, increased urine protein-to-creatinine ratio, increased urine antioxidants, serum lactate dehydrogenase (LDH), and interleukin (IL)-8 when compared with the untreated model group and the control group." | 1.48 | Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. ( Li, R; Liang, YN; Song, Y; Yang, H, 2018) |
| "sinensis) has been used to treat hyperuricemia and gout." | 1.48 | Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice. ( Barba, FJ; He, J; Li, S; Lorenzo, JM; Zhan, S; Zhang, R; Zhu, Z, 2018) |
| "Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear." | 1.46 | Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats. ( Asakawa, S; Hosoyamada, M; Kumagai, T; Morimoto, C; Nakamura, T; Shibata, S; Shiraishi, T; Tamura, Y; Uchida, S, 2017) |
| "Uric acid plays an important role in CVD pathogenesis by inducing inflammatory COX-2 and ROS pathways." | 1.46 | Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells. ( Çetin, A; Kırça, M; Oğuz, N; Yeşilkaya, A, 2017) |
| "Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints." | 1.46 | Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. ( Amaral, FA; Galvão, I; Garcia, CC; Macia, LM; Mackay, CR; Martins, FS; Sernaglia, ÉM; Sousa, LP; Tavares, LP; Teixeira, MM; Vieira, AT; Vinolo, MA, 2017) |
| "After establishing middle cerebral artery occlusion of male rats with suture method, damage and increase of ROS production in brain tissue could be seen, and after adding suitable concentration of uric acid, the degree of brain damage and ROS production was reduced." | 1.46 | Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury. ( Lin, SP; Yang, N; Zhang, B; Zhang, F, 2017) |
| "Dipyridamole pretreatment in gentamicin-administered rats afforded a noticeable renoprotection by markedly preventing renal structural and functional abnormalities, renal inflammation and serum uric acid elevation." | 1.46 | Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat. ( Bahari, MB; Balakumar, P; Gan, YS; Jayachristy, SA; JemayPuah, SM; Kuganesswari, S; Prajapati, SK; Sundram, K; Varatharajan, R; WitnessKoe, WE, 2017) |
| "Gout is a self-limited inflammatory disease caused by deposition of monosodium urate (MSU) crystals in the joints." | 1.46 | Annexin A1 promotes timely resolution of inflammation in murine gout. ( Amaral, FA; Barroso, LC; Carneiro, FS; Costa, VV; Ferreira, TP; Galvão, I; Queiroz-Junior, CM; Silva, PM; Sousa, LP; Tavares, LP; Teixeira, MM; Vago, JP, 2017) |
| "Gout is a painful disorder which does not have an efficient delivery system for its treatment." | 1.46 | Oral delivery of allopurinol niosomes in treatment of gout in animal model. ( Kaithwas, G; Kanoujia, J; Parashar, P; Saraf, SA; Singh, N; Tripathi, CB, 2017) |
| "Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome." | 1.46 | Soluble Uric Acid Activates the NLRP3 Inflammasome. ( Barbuto, JA; Braga, TT; Branco, P; Camara, NO; Castoldi, A; Correa-Costa, M; Davanso, MR; Forni, MF; Franklin, BS; Hiyane, MI; Kowaltowski, AJ; Latz, E; Ramos, RN, 2017) |
| "Treatment with uric acid protected Caco-2 cells from indomethacin-induced oxidative stress, lipid peroxidation, and cytotoxicity." | 1.46 | Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. ( Furuhashi, H; Higashiyama, M; Hokari, R; Komoto, S; Kurihara, C; Maruta, K; Matsuo, H; Miura, S; Nagao, S; Narimatsu, K; Okada, Y; Sato, H; Shirakabe, K; Takajo, T; Tomita, K; Watanabe, C; Yasutake, Y; Yoshikawa, K, 2017) |
| "Gouty arthritis is characterized by inflammation induced by monosodium urate (MSU) crystal deposition, which is resulted by an increase of serum urate concentration." | 1.43 | The effect of resveratrol on the recurrent attacks of gouty arthritis. ( Chen, H; Liu, Q; Qiu, J; Wang, Y; Xue, Y; Zheng, S; Zhu, H; Zhu, X; Zou, H, 2016) |
| " However, the pharmacokinetic studies in rats showed that its oral bioavailability was only 1." | 1.43 | Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. ( Feng, GH; Gao, LH; Li, L; Liu, HY; Liu, J; Liu, X; Niu, Y, 2016) |
| "Nitrogen dioxide (NO2) is an environmental air pollutant and endogenously generated oxidant that contributes to the exacerbation of respiratory disease and can function as an adjuvant to allergically sensitize to an innocuous inhaled Ag." | 1.43 | Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. ( Ather, JL; Boyson, JE; Burgess, EJ; Hoyt, LR; Mandal, MK; Matthews, DE; Poynter, ME; Randall, MJ, 2016) |
| "Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals." | 1.43 | Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout. ( Liang, M; Liu, L; Wang, J; Xuan, D; Xue, Y; Yang, X; Zhang, J; Zhu, X; Zhu, Y; Zou, H, 2016) |
| "Hyperuricemia is an important risk factor for atherosclerosis, yet the potential mechanisms are not well understood." | 1.42 | Uric acid promotes chemokine and adhesion molecule production in vascular endothelium via nuclear factor-kappa B signaling. ( Feng, XR; Liang, WY; Liu, ML; Wang, YC; Zhang, JW; Zhu, XY, 2015) |
| "Hyperuricemia is a common feature of patients with non-alcoholic fatty liver disease (NAFLD)." | 1.42 | Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds. ( Dooley, S; Li, Y; Miao, M; Sun, Y; Wan, X; Weng, H; Xu, C; Xu, G; Xu, L; Yan, M; Yu, C, 2015) |
| "Food allergy, in particular peanut allergy, is a growing concern in Western countries." | 1.42 | Comprehensive metabolomics identifies the alarmin uric acid as a critical signal for the induction of peanut allergy. ( Chalcraft, K; Chu, DK; Flader, K; Goncharova, S; Gordon, ME; Jimenez-Saiz, R; Jordana, M; Kong, J; Larché, M; Mandur, TS; McCarry, B; Naji, L; Walker, TD; Waserman, S, 2015) |
| " Therefore, it could be concluded that ceftriaxone and/or ascorbic acid administration able to minimize the toxic effects of DLM through their free radical-scavenging and potent antioxidant activity." | 1.42 | Synergistic protective effects of ceftriaxone and ascorbic acid against subacute deltamethrin-induced nephrotoxicity in rats. ( Abdel-Daim, MM; El-Ghoneimy, A, 2015) |
| "Hyperuricemia has been considered to be a key risk factor for kidney disease." | 1.42 | Anti-hyperuricemic and nephroprotective effects of rhein in hyperuricemic mice. ( Ding, G; Guo, C; Huang, W; Li, N; Meng, Z; Tang, Z; Wang, Z; Xiao, W; Yan, Y; Yang, Z, 2015) |
| "Gout was induced by the injection of MSU crystals into the knee joints of mice." | 1.42 | A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. ( Amaral, FA; Canesso, MC; De Leon, E; Galvão, I; Garcia, CC; Harper, JL; Macia, L; Mackay, CR; Martins, FS; Maslowski, KM; Nicoli, JR; Shim, D; Teixeira, MM; Vieira, AT, 2015) |
| "Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that might subsequently induce renal injury via metabolism by fructokinase." | 1.40 | Fructokinase activity mediates dehydration-induced renal injury. ( Aragón, A; Cicerchi, C; Correa-Rotter, R; Ejaz, AA; Glaser, J; González, MA; Inaba, S; Ishimoto, T; Johnson, RJ; Lanaspa, MA; Le, M; Miyazaki, M; Nakagawa, T; Rivard, CJ; Roncal Jimenez, CA; Sánchez-Lozada, LG; Wesseling, C, 2014) |
| "Heatstroke is one of the most common clinical emergencies." | 1.40 | Heatstroke model for desert dry-heat environment and observed organ damage. ( Liu, JW; ou Zhou, R; Zhang, D; Zhang, Q, 2014) |
| "Hyperuricemia is an important foundation of gouty arthritis." | 1.40 | Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice. ( Liu, SM; Lu, F; Yu, DH; Zhang, C; Zhou, Q, 2014) |
| " The high and low dosage of chicory inulin also decreased serum UA levels on days 7, 14, and 28." | 1.40 | Effects of chicory inulin on serum metabolites of uric acid, lipids, glucose, and abdominal fat deposition in quails induced by purine-rich diets. ( Jin, R; Lin, Z; Liu, X; Zhang, B; Zhu, W, 2014) |
| "Gout is a metabolic disorder associated with hyperuricemia resulting in the deposition of monosodium urate (MSU) crystals in joints and tissues." | 1.40 | Study on the anti-gout activity of chlorogenic acid: improvement on hyperuricemia and gouty inflammation. ( Cao, L; Ding, G; Guo, CR; Huang, WZ; Meng, ZQ; Tang, ZH; Wang, KD; Wang, ZZ; Xiao, W; Yan, YX; Yang, ZL, 2014) |
| "Rosiglitazone was administered orally at a dose of 8 mg/kg/day and PGDJ2 was given intraperitoneally at a dose of 30 μg/kg/day." | 1.40 | The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity. ( Czechowska, G; Dudka, J; Korolczuk, A; Maciejewski, M; Smolen, A; Widelska, I, 2014) |
| "Ozone is an environmentally reactive oxidant, and pycnogenol is a mixture of flavonoid compounds extracted from pine tree bark that have antioxidant activity." | 1.39 | The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure. ( Bae, DJ; Jang, AS; Lee, MS; Moon, KY; Park, MK, 2013) |
| "carota root extract on renal ischemia reperfusion injury in rats." | 1.39 | Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats. ( Afzal, M; Ahmad, A; Anwar, F; Kaur, R; Kazmi, I; Pravez, M, 2013) |
| "The adenine group was subdivided into a model control group (n = 7), a positive control group (200 mg/kg Jinshuibao capsule (JSB; n = 8), and two IF groups (200 mg/kg, n = 8; 100 mg/kg, n = 8)." | 1.39 | Nephroprotective effects of Isaria felina in rats with adenine-induced chronic renal failure. ( Bai, X; Ren, L; Yang, X; Zhang, H; Zhang, S, 2013) |
| "Patients with type 2 diabetes have similar changes in urinary pH, net acid excretion, and ammonium in 24-h urine collections at baseline, even after controlling for dietary factors, and are at increased risk for uric acid nephrolithiasis." | 1.39 | Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes. ( Adams-Huet, B; Bobulescu, IA; Capolongo, G; Maalouf, NM; Moe, OW; Rosenthal, TR; Sakhaee, K, 2013) |
| "Zajdela ascite hepatoma transplanted to the abdominal cavity of Vistar rats was used as a model of tumor growth." | 1.39 | [Effect of Zajdela ascite hepatoma growth on the extracellular antioxidant system of tumor bearer]. ( Naumov, AA; Potselueva, MM; Shatalin, IuV; Sukhomlin, TK; Zinatullina, GG, 2013) |
| "Hyperuricemia is considered as a risk factor for the development of renal dysfunction." | 1.38 | Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. ( Hu, QH; Jiao, RQ; Kong, LD; Wang, X; Zhang, X, 2012) |
| "Uric acid has also antioxidant properties and is a surrogate marker of metabolic syndrome." | 1.38 | Long-term activation of semicarbazide-sensitive amine oxidase lowers circulating levels of uric acid in diabetic conditions. ( Carpéné, C; Desquesnes, A; Gomez-Ruiz, A; Iffiú-Soltész, Z; Le Gonidec, S; Mercader, J, 2012) |
| " The long elimination half-life of mPEG-UHC in non-human primate (191." | 1.38 | Characterization, efficacy, pharmacokinetics, and biodistribution of 5kDa mPEG modified tetrameric canine uricase variant. ( Chen, Z; Fan, K; Hu, C; Liu, R; Luo, H; Ma, X; Min, Z; Wei, D; Yang, L; Zhang, C, 2012) |
| "Uremia was induced by partial nephrectomy in male Wistar rats." | 1.38 | Preconditioning protects the heart in a prolonged uremic condition. ( Bencsik, P; Csonka, C; Csont, T; Ferdinandy, P; Kocsis, GF; Pálóczi, J; Pipicz, M; Sárközy, M; Varga, ZV, 2012) |
| "KK-A(y)/Ta mice, an animal model of type 2 diabetes, were provided access to either regular drinking water or drinking water containing 10 mg/dl of allopurinol." | 1.38 | Reducing serum uric acid attenuates TGF-β1-induced profibrogenic progression in type 2 diabetic nephropathy. ( Choi, YW; Ihm, CG; Jeong, KH; Kim, SM; Lee, SH; Lee, TW; Lim, SJ; Moon, JY; Seok, HY, 2012) |
| "Acute gouty arthritis is a common inflammation model with multiple pathogenic mechanisms seen in clinical practice, for which acupuncture may potentially be an alternative therapy." | 1.37 | Effect of acupuncture on rats with acute gouty arthritis inflammation: a metabonomic method for profiling of both urine and plasma metabolic perturbation. ( Liu, YJ; Wen, SL; Xiao, J; Xue, JT; Ye, LM; Yin, HL; Zhang, L; Zhu, HY, 2011) |
| "Astilbin is a flavonoid compound isolated from the rhizome of Smilax china L." | 1.37 | Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. ( Chen, L; Lan, Z; Li, F; Li, P; Yang, Z; Zhang, C; Zhang, X; Zhou, Y, 2011) |
| "The blood Cr level just reached the chronic renal failure level on the 26th day of the administration (about the 4th week), and obviously exceeded the renal failure level on the 41st day (about the 6th week)." | 1.37 | [Exploration on the establishment of animal models for gouty nephropathy complicated with chronic renal failure]. ( Meng, DM; Ren, W; Xing, RL, 2011) |
| "After transplantation into mice with acute liver failure, ASC-derived hepatocytes can restore such liver functions as ammonia and purine metabolism." | 1.35 | Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. ( Banas, A; Kato, T; Ochiya, T; Okochi, H; Osaki, M; Takeshita, F; Teratani, T; Tokuhara, M; Yamamoto, Y, 2009) |
| "Hypertension was prevented by olmesartan, but not by allopurinol." | 1.35 | Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor. ( Kasal, DA; Mandarim-de-Lacerda, CA; Neves, MF; Oigman, W, 2008) |
| "The molecular mechanisms by which lung injury triggers IL-1beta production, inflammation, and fibrosis remain poorly understood." | 1.35 | Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. ( Charron, S; Couillin, I; Fick, L; Gasse, P; Girre, S; Lagente, V; Pétrilli, V; Quesniaux, VF; Riteau, N; Ryffel, B; Tschopp, J, 2009) |
| "Allopurinol treatment significantly lowered uric acid levels, reduced albuminuria, and ameliorated tubulointerstitial injury, but it did not prevent mesangial expansion." | 1.35 | Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. ( Heinig, M; Johnson, RJ; Kosugi, T; Nakagawa, T; Nakayama, T; Roncal, C; Sanchez-Lozada, LG; Yuzawa, Y; Zhang, L, 2009) |
| "Pretreatment with uric acid reduced 3-NT labelling in leukocytes in mesenteric tissues and in neutrophils obtained from peritoneal exudates." | 1.34 | Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice. ( Alves-Filho, JC; Celes, MR; Cunha, FQ; Dal-Secco, D; Dalto, VF; Ferreira, SH; Freitas, A; Rossi, MA; Spiller, F; Torres-Dueñas, D, 2007) |
| "Uric acid is a major antioxidant in the blood of humans that can protect cultured neurons against oxidative and metabolic insults." | 1.34 | Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice. ( Arumugam, TV; Cutler, RG; Greig, NH; Guo, Z; Haberman, F; Holloway, HW; Hyun, DH; Mattson, MP; Tang, SC; Yu, QS, 2007) |
| "To determine whether a rat model of preeclampsia includes features consistent with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome." | 1.32 | Evaluation of a rat model of preeclampsia for HELLP syndrome characteristics. ( Bennett, WA; Cockrell, KL; Granger, JP; Isler, CM; Martin, JN; Morrison, JC; Rinewalt, AN, 2003) |
| "Proteinuria was determined by the urine protein/creatinine ratio (Up/c)." | 1.32 | A functional immature model of chronic partial ureteral obstruction. ( Abitbol, CL; Au, J; Beharrie, A; Franc-Guimond, J; Rodriguez, MM; Zilleruelo, G, 2004) |
| "Sesame oil ameliorated multiple organ failure and mortality via its inhibition of xanthine oxidase in lipopolysaccharide-dosed rats." | 1.31 | Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats. ( Hsu, DZ; Liu, MY, 2002) |
| "Uric acid (UA) is a natural scavenger of ONOO(-) that is present at high levels in the sera of humans and other higher order primates relative to most lower mammals." | 1.31 | Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "Gout is an acute rheumatic disorder that occurs in connection with the deposition of monosodium urate (MSU) crystals in the joints." | 1.30 | Altered arachidonic acid metabolism in urate crystal induced inflammation. ( Duffin, KL; Gregory, SA; Isakson, PC; Margalit, A; Shaffer, AF, 1997) |
| "Uric acid was successfully used to treat experimental allergic encephalomyelitis, the mouse model of multiple sclerosis (M." | 1.30 | [Uric acid as a scavenger in oxidative stress]. ( Staub, M, 1999) |
| "Cisplatin caused differential toxic effects on blood glucose and plasma urea, uric acid and creatinine levels." | 1.30 | Rehabilitating role of glutathione ester on cisplatin induced nephrotoxicity. ( Babu, E; Chandramohan, N; Ebrahim, AS; Sakthisekaran, D, 1999) |
| "To test whether intermittent hypoxemia could, in part, explain this observed difference, Hx, xanthine (X), and uric acid were measured in vitreous humor, urine, plasma, and cerebrospinal fluid in newborn piglets during intermittent hypoxemia (IH) or continuous hypoxemia (CH) of equal degree and duration." | 1.29 | Hypoxanthine, xanthine, and uric acid concentrations in plasma, cerebrospinal fluid, vitreous humor, and urine in piglets subjected to intermittent versus continuous hypoxemia. ( Oyasaeter, S; Rognum, TO; Rootwelt, T; Saugstad, OD; Stoltenberg, L, 1993) |
| "We present here two models of prolonged hyperalgesia in the rat induced by intra-articular injection of uric acid or Freund's complete adjuvant into the knee." | 1.29 | The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat. ( Davis, A; Perkins, MN, 1993) |
| " The time-course and dose-response of associated inflammation and sensory abnormalities are described." | 1.27 | Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund's adjuvant. ( Coderre, TJ; Wall, PD, 1987) |
| "Thus, in acute renal failure, tubular functional impairments may recover at different rates." | 1.26 | Renal function in rats with acute medullary injury. ( Brown, EA; Finkelstein, FO; Hayslett, JP; Kliger, AS, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (9.19) | 18.7374 |
| 1990's | 29 (5.23) | 18.2507 |
| 2000's | 87 (15.68) | 29.6817 |
| 2010's | 283 (50.99) | 24.3611 |
| 2020's | 105 (18.92) | 2.80 |
| Authors | Studies |
|---|---|
| Ohtsuki, S | 1 |
| Kikkawa, T | 1 |
| Mori, S | 1 |
| Hori, S | 1 |
| Takanaga, H | 1 |
| Otagiri, M | 2 |
| Terasaki, T | 1 |
| Wang, Y | 18 |
| Zhu, W | 2 |
| Lu, D | 1 |
| Zhang, C | 7 |
| Pan, J | 2 |
| Shi, M | 2 |
| Guo, F | 2 |
| Ma, L | 4 |
| Fu, P | 2 |
| Goo, B | 1 |
| Lee, J | 2 |
| Park, C | 1 |
| Yune, T | 1 |
| Park, Y | 1 |
| Zhou, GQ | 1 |
| Chen, G | 4 |
| Yang, J | 3 |
| Qin, WY | 1 |
| Ping, J | 1 |
| Lin, G | 1 |
| Yu, Q | 1 |
| Xu, L | 7 |
| Huang, Z | 3 |
| Mai, L | 1 |
| Jiang, L | 1 |
| Su, Z | 2 |
| Xie, J | 3 |
| Li, Y | 18 |
| Liu, Y | 10 |
| Lin, Z | 2 |
| Chen, J | 8 |
| Wang, F | 5 |
| Zhao, X | 2 |
| Su, X | 3 |
| Song, D | 1 |
| Zou, F | 1 |
| Fang, L | 2 |
| Brien, ME | 2 |
| Hughes, K | 1 |
| Girard, S | 2 |
| Obayemi, MJ | 1 |
| Akintayo, CO | 1 |
| Oniyide, AA | 2 |
| Aturamu, A | 1 |
| Badejogbin, OC | 2 |
| Atuma, CL | 1 |
| Saidi, AO | 1 |
| Mahmud, H | 1 |
| Olaniyi, KS | 2 |
| Zhang, J | 16 |
| Lei, H | 1 |
| Li, X | 15 |
| Accart, N | 1 |
| Dawson, J | 1 |
| Obrecht, M | 1 |
| Lambert, C | 1 |
| Flueckiger, M | 1 |
| Kreider, J | 1 |
| Hatakeyama, S | 1 |
| Richards, PJ | 1 |
| Beckmann, N | 1 |
| Hu, BY | 1 |
| Zhao, YL | 2 |
| Ma, DY | 1 |
| Xiang, ML | 1 |
| Zhao, LX | 1 |
| Luo, XD | 1 |
| Mei, A | 1 |
| Liu, X | 12 |
| Braunstein, Z | 1 |
| Wei, Y | 6 |
| Wang, B | 5 |
| Duan, L | 2 |
| Rao, X | 2 |
| Rajagopalan, S | 1 |
| Dong, L | 1 |
| Zhong, J | 2 |
| Hsu, CJ | 1 |
| Lin, WC | 1 |
| Chou, YC | 1 |
| Yang, CM | 1 |
| Wu, HL | 2 |
| Cheng, YH | 1 |
| Liu, PC | 1 |
| Chang, JY | 1 |
| Chen, HY | 1 |
| Sun, JR | 1 |
| Suzuki, K | 1 |
| Tsuchiya, M | 1 |
| Yoshida, S | 1 |
| Ogawa, K | 1 |
| Chen, W | 4 |
| Kanzaki, M | 1 |
| Takahashi, T | 1 |
| Fujita, R | 1 |
| Yabe, Y | 1 |
| Aizawa, T | 1 |
| Hagiwara, Y | 1 |
| Yuan, D | 2 |
| Lin, L | 2 |
| Peng, Y | 1 |
| Zhou, Y | 7 |
| Li, L | 9 |
| Xiao, W | 3 |
| Gong, Z | 2 |
| Tian, J | 5 |
| Zhou, D | 2 |
| Xiang, L | 2 |
| Xie, B | 2 |
| Yang, C | 2 |
| Su, HY | 1 |
| An, N | 1 |
| Guo, XY | 1 |
| Li, ZH | 1 |
| Chen, XC | 1 |
| Zhu, SP | 1 |
| Wu, D | 4 |
| Li, HY | 1 |
| Pan, QJ | 1 |
| Liang, D | 2 |
| Liu, HF | 1 |
| Shui, G | 1 |
| Cai, Z | 2 |
| Chen, T | 1 |
| Huang, X | 3 |
| Cai, Y | 2 |
| Mi, X | 2 |
| Fu, YP | 1 |
| Li, CY | 1 |
| Peng, X | 1 |
| Wangensteen, H | 1 |
| Inngjerdingen, KT | 1 |
| Zou, YF | 1 |
| Chen, Y | 15 |
| Cao, P | 4 |
| Xiao, Z | 4 |
| Ruan, Z | 3 |
| Galvão, I | 9 |
| Mastrippolito, D | 2 |
| Talamini, L | 2 |
| Aganetti, M | 2 |
| Rocha, V | 2 |
| Verdot, C | 2 |
| Mendes, V | 2 |
| de Oliveira, VLS | 2 |
| Braga, AD | 2 |
| Martins, VD | 2 |
| de Faria, AMC | 2 |
| Amaral, FA | 8 |
| Georgel, P | 3 |
| Vieira, AT | 5 |
| Muller, S | 2 |
| Mohapatra, A | 1 |
| Rajendrakumar, SK | 1 |
| Chandrasekaran, G | 1 |
| Revuri, V | 1 |
| Sathiyamoorthy, P | 1 |
| Lee, YK | 1 |
| Lee, JH | 1 |
| Choi, SY | 1 |
| Park, IK | 2 |
| Mbiakop, UC | 1 |
| Gomes, JHS | 1 |
| Pádua, RM | 1 |
| Lemos, VS | 1 |
| Braga, FC | 1 |
| Cortes, SF | 1 |
| Wang, JC | 1 |
| Tsai, SH | 1 |
| Tsai, HY | 1 |
| Lin, SJ | 1 |
| Huang, PH | 1 |
| Li, H | 10 |
| Wang, R | 2 |
| Yu, Y | 4 |
| Tian, Z | 3 |
| Yang, L | 2 |
| Wu, H | 1 |
| Luo, C | 2 |
| Zhao, Y | 3 |
| Dai, R | 1 |
| Li, Z | 9 |
| Zhang, X | 12 |
| Shen, Y | 2 |
| Yu, F | 3 |
| Li, W | 4 |
| Zhao, H | 4 |
| Zhang, T | 4 |
| Zhu, J | 3 |
| Fu, Y | 2 |
| Wang, J | 12 |
| Kong, W | 3 |
| Hao, P | 1 |
| Sun, X | 3 |
| Ward, R | 1 |
| Tang, T | 1 |
| Chen, X | 5 |
| Luo, G | 1 |
| Yang, Y | 6 |
| Xiang, C | 1 |
| An, S | 1 |
| Xu, TR | 1 |
| Yin, W | 1 |
| Zhou, QL | 1 |
| OuYang, SX | 1 |
| Gong, YT | 1 |
| Liang, YM | 1 |
| Lang, S | 1 |
| Hilsabeck, TA | 1 |
| Wilson, KA | 1 |
| Sharma, A | 1 |
| Bose, N | 1 |
| Brackman, DJ | 1 |
| Beck, JN | 1 |
| Chen, L | 7 |
| Watson, MA | 1 |
| Killilea, DW | 1 |
| Ho, S | 1 |
| Kahn, A | 1 |
| Giacomini, K | 1 |
| Stoller, ML | 1 |
| Chi, T | 1 |
| Kapahi, P | 1 |
| Højen, JF | 1 |
| Kristensen, MLV | 1 |
| McKee, AS | 1 |
| Wade, MT | 1 |
| Azam, T | 1 |
| Lunding, LP | 1 |
| de Graaf, DM | 1 |
| Swartzwelter, BJ | 1 |
| Wegmann, M | 1 |
| Tolstrup, M | 1 |
| Beckman, K | 1 |
| Fujita, M | 2 |
| Fischer, S | 1 |
| Dinarello, CA | 2 |
| Guo, Y | 2 |
| Liu, Z | 4 |
| Li, C | 8 |
| Jiang, C | 1 |
| Li, K | 1 |
| Neumann, K | 2 |
| Duhan, V | 1 |
| Namineni, S | 1 |
| Hansen, AL | 1 |
| Wartewig, T | 1 |
| Kurgyis, Z | 1 |
| Holm, CK | 1 |
| Heikenwalder, M | 1 |
| Lang, KS | 1 |
| Ruland, J | 1 |
| Chen, B | 2 |
| Ou, G | 1 |
| Ren, L | 2 |
| Yang, X | 5 |
| Zeng, M | 1 |
| Lyu, S | 1 |
| Ding, R | 1 |
| Liu, P | 1 |
| OuYang, H | 1 |
| Feng, Y | 4 |
| Rao, Y | 1 |
| Yang, S | 4 |
| Li, M | 2 |
| Wu, JL | 1 |
| Li, JX | 1 |
| Ma, ZC | 1 |
| Zhang, W | 1 |
| Du, W | 1 |
| Li, G | 3 |
| Yang, W | 1 |
| Chen, H | 5 |
| Nipate, SS | 1 |
| Yelmar, PS | 1 |
| Marinho, Y | 1 |
| Marques-da-Silva, C | 1 |
| Santana, PT | 1 |
| Chaves, MM | 1 |
| Tamura, AS | 1 |
| Rangel, TP | 1 |
| Gomes-E-Silva, IV | 1 |
| Guimarães, MZP | 1 |
| Coutinho-Silva, R | 1 |
| Kandav, G | 1 |
| Bhatt, DC | 1 |
| Jindal, DK | 1 |
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| Parashar, P | 2 |
| Mazhar, I | 1 |
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| Han, H | 1 |
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| Zhang, Y | 13 |
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| Loeffler, DA | 1 |
| Camp, DM | 1 |
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| LeWitt, PA | 1 |
| Díaz, MI | 1 |
| Hernández, GP | 1 |
| Domínguez, AM | 1 |
| García, ML | 1 |
| Al-Awadi, FM | 1 |
| Khan, I | 1 |
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| Ledbetter, AD | 1 |
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| Delnomdedieu, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Losartan and Uric Acid Metabolism in Children With Proteinuric Nephropathies: a Cross-over Randomized Clinical Trail[NCT05402397] | Phase 4 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Study on the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention[NCT03425708] | Phase 4 | 400 participants (Anticipated) | Interventional | 2017-01-01 | Recruiting | ||
| Genetic-specific Effects of Fructose on Liver Lipogenesis[NCT03783195] | 15 participants (Actual) | Interventional | 2019-01-25 | Completed | |||
| Comparative Study Evaluating the Outcome of Febuxostat Versus Vitamin E in Hyperuricemia Patients With Non-alcoholic Steatohepatitis Without Cirrhosis[NCT05574036] | Phase 2 | 70 participants (Anticipated) | Interventional | 2022-08-25 | Recruiting | ||
| Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | ||
| The Effect of Acute Fructose Load in Patients With Chronic Kidney Disease and Patients With Type 2 Diabetes Compared to Healthy Subjects[NCT03157960] | 20 participants (Actual) | Interventional | 2012-02-01 | Completed | |||
| Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial[NCT02502071] | Phase 4 | 45 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 As Biomarkers of Acute Kidney Injury in Children With Diabetic Ketoacidosis[NCT06032325] | 48 participants (Anticipated) | Observational [Patient Registry] | 2024-01-01 | Not yet recruiting | |||
| Postprandial Modulation of HDL Metabolism[NCT01803594] | 18 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| Effects of Dairy Fat on Postprandial Inflammation- Phase 1[NCT01811329] | 38 participants (Actual) | Interventional | 2013-08-01 | Active, not recruiting | |||
| Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)[NCT03317925] | 29 participants (Actual) | Observational | 2014-07-16 | Completed | |||
| A Cohort Dose-Escalation Phase 1 Study of Intravenous Infusion of Uricase-PEG 20[NCT01021241] | Phase 1 | 20 participants (Anticipated) | Interventional | 2009-10-31 | Active, not recruiting | ||
| A Cohort Dose-Escalation Phase 1 Study of Intramuscular Injection of Uricase-PEG 20[NCT01038947] | Phase 1 | 28 participants (Anticipated) | Interventional | 2009-12-31 | Recruiting | ||
| ACTH vs Betamethasone for the Treatment of Acute Gout in Hospitalized Patients: A Randomized, Open Label, Comparative Study[NCT04306653] | 60 participants (Anticipated) | Interventional | 2018-01-05 | Recruiting | |||
| Effect of Low Dose of Colchicine on Platelet Reactivty in Patients With Chronic Coronary Disease[NCT05956145] | Phase 3 | 80 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| Treatment of Multiple Sclerosis Using Over the Counter Inosine[NCT00067327] | Phase 2 | 30 participants | Interventional | 2002-02-28 | Completed | ||
| A Phase II Multidose Study of Intravenous PEG-uricase in Patients With Refractory Gout[NCT00111657] | Phase 2 | 30 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Urine uric acid crystals were identified by polarized microscopy (Polarized light imaging Zeiss Axiovert 135; 0.3NA objective), and pictures were captured from each urine sample. UA crystals were defined dichotomously as being present or absent. (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)
| Intervention | participants (Number) | |
|---|---|---|
| Day 1 (pre-therapy) | Day 2 (post-therapy) | |
| Sodium Bicarbonate | 14 | 3 |
Urine uric acid were evaluated using a QuantiChrom UA kit assay (DIUA-250) with quantitative colorimetric UA determination at 590 nm (BioAssay System, California, USA). (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)
| Intervention | mg/dl (Geometric Mean) | |
|---|---|---|
| Day 1 (pre-therapy) | Day 2 (post-therapy) | |
| Sodium Bicarbonate | 23.81 | 22.30 |
Number of patients who developed antibodies to PEG-uricase (NCT00111657)
Timeframe: baseline, then prior to infusions and 7 wks after last infusion
| Intervention | participants (Number) |
|---|---|
| Pegloticase | 15 |
The highest drug concentration in the blood after the first infusion of study drug. (NCT00111657)
Timeframe: 2 hours
| Intervention | mU/mL (Mean) |
|---|---|
| Single Arm - Pegloticase | 25.6 |
The lowest drug concentration in the blood after the first infusion of study drug. (NCT00111657)
Timeframe: 21 days after the infusion
| Intervention | mU/mL (Mean) |
|---|---|
| Single Arm - Pegloticase | 4.9 |
(NCT00111657)
Timeframe: Baseline to Day 105
| Intervention | Participants (Number) |
|---|---|
| Single Arm | 17 |
Count of tenderness and swelling of 68 joints (NCT00111657)
Timeframe: Basline and day 134
| Intervention | joints (Median) | |||
|---|---|---|---|---|
| Number of Tender joints at baseline | Number of Tender joints at day 134 | Number of Swollen jonts at baseline | Number of Swollen jonts at day 134 | |
| Pegloticase | 13 | 2 | 9 | 6 |
38 reviews available for uric acid and Disease Models, Animal
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Animal models of naturally occurring stone disease.
Topics: Animals; Biomedical Research; Calcium Oxalate; Cats; Cystine; Disease Models, Animal; Dogs; Dolphins | 2020 |
Emergent nanotherapies in microcrystal-induced arthritis.
Topics: Animals; Calcium Phosphates; Chitosan; Chondrocalcinosis; Crystal Arthropathies; Diclofenac; Disease | 2018 |
Uric acid and progression of chronic kidney disease.
Topics: Age Factors; Allopurinol; Animals; Child; Diet Therapy; Disease Models, Animal; Disease Progression; | 2019 |
Targeting kidney inflammation as a new therapy for primary hyperoxaluria?
Topics: Adolescent; Adult; Animals; Calcium Oxalate; Child; Child, Preschool; Disease Models, Animal; Humans | 2019 |
Mouse models for human hyperuricaemia: a critical review.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Glucose Transport Proteins, Facilitativ | 2019 |
Sugar, uric acid, and the etiology of diabetes and obesity.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Sucrose; Disease Models, Animal | 2013 |
Uric acid, hypertension, and cardiovascular and renal complications.
Topics: Animals; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Uric Acid; Va | 2013 |
The role of uric acid in kidney fibrosis: experimental evidences for the causal relationship.
Topics: Animals; Disease Models, Animal; Fibrosis; Humans; Inflammation; Renal Insufficiency, Chronic; Uric | 2014 |
Pain and microcrystalline arthritis.
Topics: Animals; Arthritis, Gouty; Calcium Pyrophosphate; Chronic Pain; Crystallization; Dinoprostone; Disea | 2014 |
[Pleiotropic effects of sevelamer: a model of intestinal tract chelating agent].
Topics: Animals; Bone Remodeling; Cardiovascular Diseases; Chelating Agents; Chelation Therapy; Disease Mode | 2014 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Can the silkworm (Bombyx mori) be used as a human disease model?
Topics: Animals; Antiparkinson Agents; Bombyx; Disease Models, Animal; Drug Discovery; Gene Expression Profi | 2016 |
Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructose; Glycat | 2017 |
Uric acid: bystander or culprit in hypertension and progressive renal disease?
Topics: Animals; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Rats; Uric Ac | 2008 |
The role of hyperuricemia in vascular disorders.
Topics: Animals; Biological Evolution; Cardiovascular Diseases; Disease Models, Animal; Humans; Hypertension | 2009 |
Uric acid: a novel mediator and marker of risk in chronic kidney disease?
Topics: Animals; Biomarkers; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Disease Prog | 2009 |
Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect?
Topics: Animals; Antioxidants; Cardiovascular Diseases; Cells, Cultured; Clinical Trials as Topic; Comorbidi | 2010 |
Mechanisms of inflammation in gout.
Topics: Acute Disease; Animals; Carrier Proteins; Chemotaxis, Leukocyte; Crystallization; Disease Models, An | 2010 |
Dietary fructose and hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Fructose; Humans; Hypertensi | 2011 |
Serum uric acid as a new player in the development of diabetic nephropathy.
Topics: Allopurinol; Animals; Antimetabolites; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Mo | 2011 |
The role of uric acid as an endogenous danger signal in immunity and inflammation.
Topics: Adjuvants, Immunologic; Animals; Autoimmunity; Carrier Proteins; Crystallization; Disease Models, An | 2011 |
Role of melanocortin receptors in the regulation of gouty inflammation.
Topics: Allopurinol; Animals; Arthritis, Gouty; Colchicine; Crystallization; Disease Models, Animal; Gout Su | 2011 |
Uric acid as a mediator of diabetic nephropathy.
Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Humans; Uric Acid | 2011 |
The role of uric acid in the pathogenesis of hypertension in the young.
Topics: Age Factors; Animals; Child; Child Welfare; Disease Models, Animal; Humans; Hypertension; Hyperurice | 2012 |
Recent applications of engineered animal antioxidant deficiency models in human nutrition and chronic disease.
Topics: Animals; Animals, Genetically Modified; Antioxidants; Ascorbic Acid Deficiency; Deficiency Diseases; | 2013 |
Pleural models of inflammation: immune and nonimmune.
Topics: Animals; Arthritis; Arthus Reaction; Calcium Pyrophosphate; Carrageenan; Cattle; Crystallization; Di | 2003 |
[Researches on the establishment of chronic nephropathy models and the effect of TCM on these models].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hyperuricemia; Kidney Diseases; Mice; Phytot | 2005 |
Serum uric acid: a risk factor and a target for treatment?
Topics: Adolescent; Adult; Animals; Blood Pressure; Cardiovascular Diseases; Child; Clinical Trials as Topic | 2006 |
Uric acid and hypertension.
Topics: Animals; Child; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Rats; Uric Acid | 2006 |
Uric acid, the metabolic syndrome, and renal disease.
Topics: Animals; Disease Models, Animal; Disease Progression; Fructose; Humans; Kidney Diseases; Metabolic S | 2006 |
[Animal model for gout].
Topics: Animals; Chickens; Disease Models, Animal; Female; Gout; Male; Mice; Oxonic Acid; Poultry Diseases; | 1982 |
Is there a role for uric acid in an animal model of calcium phosphate nephrocalcinosis and calcium phosphate crystallization in urine of patients with idiopathic calcium urolithiasis? An orientational study.
Topics: Animals; Calcium; Calcium Phosphates; Crystallization; Disease Models, Animal; Humans; Nephrocalcino | 1999 |
Use of the uricase-inhibited rat as an animal model in toxicology.
Topics: Aggression; Animals; Diet; Disease Models, Animal; Dogs; Embryo, Mammalian; Female; Gout; Humans; Ki | 1978 |
Renal hypouricemia: classification, tubular defect and clinical consequences.
Topics: Animals; Disease Models, Animal; Humans; Kidney Diseases; Kidney Tubules; Uric Acid | 1992 |
Crystal deposition in osteoarthritis: an opportunistic event?
Topics: Animals; Arthropathy, Neurogenic; Calcium Pyrophosphate; Cartilage, Articular; Cholesterol; Chondroc | 1985 |
Calcium oxalate urolithiasis in the rat: is it a model for human stone disease? A review of recent literature.
Topics: Animals; Calcium Oxalate; Diet; Disease Models, Animal; Ethylene Glycols; Female; Foreign Bodies; Gl | 1985 |
Biochemical and genetic studies of an X-linked neurological disease (The Lesch-Nyhan syndrome).
Topics: Animals; Athetosis; Cells, Cultured; Cerebral Palsy; Child; Disease Models, Animal; Feedback; Female | 1971 |
3 trials available for uric acid and Disease Models, Animal
| Article | Year |
|---|---|
Simiao pill inhibits epithelial mesenchymal transition in a mouse model of chronic hyperuricemic nephropathy by inhibiting NLRP3 inflammasome activation.
Topics: Actins; Animals; Cadherins; Caspases; Disease Models, Animal; Epithelial-Mesenchymal Transition; Feb | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Knockout; Middle | 2018 |
515 other studies available for uric acid and Disease Models, Animal
| Article | Year |
|---|---|
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Ma | 2004 |
Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Berberine Alkaloids; | 2021 |
Pharmacologic inhibiting STAT3 delays the progression of kidney fibrosis in hyperuricemia-induced chronic kidney disease.
Topics: Aminosalicylic Acids; Animals; Benzenesulfonates; Disease Models, Animal; Fibrosis; Hyperuricemia; K | 2021 |
Bee Venom Alleviated Edema and Pain in Monosodium Urate Crystals-Induced Gouty Arthritis in Rat by Inhibiting Inflammation.
Topics: Animals; Arthritis, Gouty; Bee Venoms; Disease Models, Animal; Edema; Humans; Inflammation; Male; Pa | 2021 |
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Topics: Animals; Caspase 1; Disease Models, Animal; Drugs, Chinese Herbal; Gout; Inflammasomes; Inflammation | 2022 |
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Berberine; Blood Urea Nitrogen; Ch | 2021 |
Isorhamnetin, the xanthine oxidase inhibitor from
Topics: Animals; Disease Models, Animal; Hyperuricemia; Kidney; Male; Mice; Quercetin; Sophora; Uric Acid; X | 2021 |
Prenatal administration of IL-1Ra attenuate the neurodevelopmental impacts following non-pathogenic inflammation during pregnancy.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; Fetal Development; Fetal Growth Re | 2021 |
Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Ghrelin | 2021 |
The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.
Topics: Animals; Arthritis, Gouty; Cells, Cultured; Colchicine; Disease Models, Animal; Macrophages; Malondi | 2022 |
Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging.
Topics: Animals; Arthritis, Gouty; Biopsy; Crystallization; Cytokines; Disease Models, Animal; Disease Progr | 2022 |
Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro.
Topics: Alstonia; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hype | 2022 |
Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation.
Topics: Animals; Cell Movement; Disease Models, Animal; Gene Expression Regulation; Glucagon-Like Peptide-1 | 2022 |
Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19.
Topics: Animals; COVID-19; Cricetinae; Disease Models, Animal; Humans; Lipoproteins, LDL; Lung; Male; Mesocr | 2022 |
Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model.
Topics: Animals; Disease Models, Animal; DNA; Extracellular Traps; Febuxostat; Histones; Hyperalgesia; Mice; | 2022 |
Effects of black tea and black brick tea with fungal growth on lowering uric acid levels in hyperuricemic mice.
Topics: Animals; Camellia sinensis; Disease Models, Animal; Hyperuricemia; Mice; Organic Anion Transporters; | 2022 |
Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF-κB and p62-Keap1 pathways.
Topics: Animals; Arthritis, Gouty; Caspase 1; Disease Models, Animal; DNA-Binding Proteins; Inflammasomes; I | 2022 |
AMP-activated protein kinase α2 contributes to acute and chronic hyperuricemic nephropathy via renal urate deposition in a mouse model.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Fibrosis; Hyperuricemia; Kidney; Kid | 2022 |
Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
Topics: Aconitum; Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Fat | 2022 |
m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome.
Topics: Adaptor Proteins, Signal Transducing; Animals; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cu | 2022 |
m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome.
Topics: Adaptor Proteins, Signal Transducing; Animals; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cu | 2022 |
m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome.
Topics: Adaptor Proteins, Signal Transducing; Animals; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cu | 2022 |
m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome.
Topics: Adaptor Proteins, Signal Transducing; Animals; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cu | 2022 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Mice; Neutrophils; Ph | 2022 |
Biomineralized Nanoscavenger Abrogates Proinflammatory Macrophage Polarization and Induces Neutrophil Clearance through Reverse Migration during Gouty Arthritis.
Topics: Animals; Arthritis, Gouty; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Inflammation; Macrop | 2023 |
Oral sub-chronic treatment with Terminalia phaeocarpa Eichler (Combretaceae) reduces liver PTP1B activity in a murine model of diabetes.
Topics: Animals; Blood Glucose; Cholesterol; Combretaceae; Diabetes Mellitus, Experimental; Disease Models, | 2023 |
Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Human | 2023 |
Protective effect of sodium butyrate on intestinal barrier damage and uric acid reduction in hyperuricemia mice.
Topics: Animals; Butyric Acid; Caco-2 Cells; Disease Models, Animal; Fatty Acids, Volatile; Humans; Hyperuri | 2023 |
Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice.
Topics: Allopurinol; Aminopropionitrile; Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Disease Mode | 2023 |
New animal model of chronic gout reproduces pathological features of the disease in humans.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Gout Suppressants; Humans; Mice; Uric Acid | 2023 |
Uric acid regulates NLRP3/IL-1β signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K
Topics: Animals; Creatinine; Disease Models, Animal; Endothelium, Vascular; Human Umbilical Vein Endothelial | 2019 |
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
Topics: Animals; Animals, Genetically Modified; Cohort Studies; Disease Models, Animal; Drosophila melanogas | 2019 |
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
Topics: A549 Cells; Animals; Antibodies, Blocking; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, | 2019 |
Impaired intestinal barrier function in a mouse model of hyperuricemia.
Topics: Animals; Disease Models, Animal; Hyperuricemia; Interleukin-6; Intestinal Mucosa; Mice; Mice, Knocko | 2019 |
The uric acid crystal receptor Clec12A potentiates type I interferon responses.
Topics: Alarmins; Animals; Cytosol; DEAD Box Protein 58; Disease Models, Animal; Humans; Immunity, Innate; I | 2019 |
Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Curcumin; Cytokines; Disease Mo | 2019 |
LC-MS Analysis of Serum for the Metabolomic Investigation of the Effects of Pulchinenoside b4 Administration in Monosodium Urate Crystal-Induced Gouty Arthritis Rat Model.
Topics: Animals; Arthritis, Gouty; Biomarkers; Chromatography, Liquid; Crystallization; Discriminant Analysi | 2019 |
Effect of lemon water soluble extract on hyperuricemia in a mouse model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Citrus; Disease Models, Animal; Fr | 2019 |
Constituents and Anti-Hyperuricemia Mechanism of Traditional Chinese Herbal Formulae Erding Granule.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Disease Models, Animal; Dos | 2019 |
Therapeutic potential of ethyl acetate fraction of Tephrosia purpurea Linn. leaves in a rat model of gout.
Topics: Acetates; Animals; Disease Models, Animal; Gout; Male; Plant Extracts; Plant Leaves; Rats; Rats, Spr | 2019 |
MSU Crystals induce sterile IL-1β secretion via P2X7 receptor activation and HMGB1 release.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Edema; HMGB1 Protein; Humans; Inflammation; | 2020 |
Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis.
Topics: Administration, Oral; Allopurinol; Animals; Chemical Precipitation; Chitosan; Disease Models, Animal | 2019 |
Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models.
Topics: Animals; Blood Urea Nitrogen; Calcium; China; Disease Models, Animal; Drugs, Chinese Herbal; Kidney; | 2019 |
Appraisal of anti-gout potential of colchicine-loaded chitosan nanoparticle gel in uric acid-induced gout animal model.
Topics: Animals; Chitosan; Colchicine; Disease Models, Animal; Gout; Nanoparticles; Uric Acid | 2022 |
Urate Transporter URAT1 in Hyperuricemia: New Insights from Hyperuricemic Models.
Topics: Animals; Benzbromarone; Disease Models, Animal; Febuxostat; HEK293 Cells; Humans; Hyperuricemia; Kid | 2019 |
Electrochemical analysis of uric acid excretion to the intestinal lumen: Effect of serum uric acid-lowering drugs and 5/6 nephrectomy on intestinal uric acid levels.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cardiovascular Diseases; Disease M | 2019 |
Impacts of a Specific Cyclooxygenase-2 Inhibitor on Pressure Overload-Induced Myocardial Hypertrophy in Rats.
Topics: Animals; C-Reactive Protein; Cardiomegaly; Celecoxib; Cyclooxygenase 2 Inhibitors; Diet; Dinoproston | 2019 |
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Topics: Animals; Benzimidazoles; Benzoxazoles; Cell Line; Disease Models, Animal; Gout; Humans; Hyperuricemi | 2020 |
Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Contusions; Creatine Kinase; Creatin | 2020 |
Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.
Topics: Allopurinol; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Febuxostat; Hyperuricemia | 2020 |
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.
Topics: Adult; AMP-Activated Protein Kinases; Animals; Atherosclerosis; Benzbromarone; Biomarkers; Disease M | 2020 |
Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency.
Topics: Adenine; Animals; Calcium; Disease Models, Animal; Gene Expression Regulation; Kidney Cortex; Male; | 2020 |
Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Humans; Immunity, Innate; Inflammation Mediators | 2020 |
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Ca | 2020 |
Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease.
Topics: Adult; Aldehyde Reductase; Animals; Apoptosis; Case-Control Studies; Cohort Studies; Disease Models, | 2020 |
A mouse model of MSU-induced acute inflammation
Topics: Acute Disease; Adjuvants, Immunologic; Administration, Topical; Animals; Antioxidants; Cytokines; Di | 2020 |
The role of annexin A1 in the modulation of the NLRP3 inflammasome.
Topics: Administration, Intranasal; Animals; Annexin A1; Cartilage, Articular; Caspase 1; Cells, Cultured; D | 2020 |
Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Creatinine; Disease Models, Animal; Diuresis; Hype | 2020 |
CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout.
Topics: Animals; Arthritis, Gouty; Cell Line; Cells, Cultured; Crystallization; Disease Models, Animal; Huma | 2020 |
Goose astrovirus infection affects uric acid production and excretion in goslings.
Topics: Animals; Astroviridae Infections; Avastrovirus; Avian Proteins; Carrier Proteins; Disease Models, An | 2020 |
High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout.
Topics: Allopurinol; Animal Structures; Animals; Chickens; Crystallization; Diet, High-Protein; Disease Mode | 2020 |
X-ray Dark-Field Radiography: Potential for Visualization of Monosodium Urate Deposition.
Topics: Animals; Disease Models, Animal; Gout; Humans; Mice; Photons; Radiography; Sensitivity and Specifici | 2020 |
Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat's model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Drug Developmen | 2020 |
1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol (PLAG) Mitigates Monosodium Urate (MSU)-Induced Acute Gouty Inflammation in BALB/c Mice.
Topics: Acute Disease; Animals; Arthritis, Gouty; Cell Movement; Diglycerides; Disease Models, Animal; Human | 2020 |
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion.
Topics: Alleles; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Disease Models, Animal; E | 2020 |
Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats.
Topics: Adenine; Animals; Biomarkers; Disease Models, Animal; Down-Regulation; Ethambutol; Flowers; Glucosid | 2020 |
Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy.
Topics: Animals; Autophagy; Disease Models, Animal; Disease Progression; Female; Humans; Hyperuricemia; Kidn | 2020 |
The role of resistin on metabolic syndrome-induced erectile dysfunction and the possible therapeutic effect of Boldine.
Topics: Animals; Antioxidants; Aporphines; Blood Glucose; Blood Pressure; Disease Models, Animal; Erectile D | 2020 |
NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Glucosides; | 2020 |
The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Chromatography, High Pres | 2020 |
Integration of GWAS Summary Statistics and Gene Expression Reveals Target Cell Types Underlying Kidney Function Traits.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Genome-Wide Association Study; Glo | 2020 |
A novel mouse model of hyperuricemia and gouty nephropathy.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Hyperuricemia; Mice; Uric Acid | 2020 |
Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals.
Topics: Aminosalicylic Acids; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Dose-Respons | 2020 |
Matrix Metalloproteinase-3 induces proteoglycan degradation in gouty arthritis model.
Topics: Animals; Arthritis, Gouty; Chondrocytes; Cytokines; Disease Models, Animal; Hyperuricemia; Interleuk | 2021 |
Lipophilic Extract and Tanshinone IIA Derived from
Topics: Abietanes; Animals; Cells, Cultured; Crystallization; Disease Models, Animal; Humans; Hydrophobic an | 2020 |
Effects of repeated increasing doses of cisplatin as models of acute kidney injury and chronic kidney disease in rats.
Topics: Acute Kidney Injury; Albuminuria; Animals; Antineoplastic Agents; Caspase 3; Cisplatin; Creatinine; | 2021 |
Non-purine selective xanthine oxidase inhibitor ameliorates glomerular endothelial injury in Ins
Topics: Albuminuria; Ameloblasts; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease | 2020 |
Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Blood Sedimentation; Bone and Bones; C-Reactive | 2020 |
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Topics: Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibitors; Flavanones; Glucose Transport Prot | 2021 |
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.
Topics: Animals; Cell Nucleus; Disease Models, Animal; Down-Regulation; Fibrosis; Hep G2 Cells; Humans; Hype | 2020 |
Increased Susceptibility of Atrial Fibrillation Induced by Hyperuricemia in Rats: Mechanisms and Implications.
Topics: Actins; Animals; Apoptosis; Atrial Fibrillation; Atrial Remodeling; bcl-2-Associated X Protein; Benz | 2021 |
Effects of long-term hydrogen intervention on the physiological function of rats.
Topics: Animals; Blood Glucose; Body Weight; China; Disease Models, Animal; Heart; Hydrogen; Liver; Male; My | 2020 |
Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats.
Topics: Animals; Anti-Inflammatory Agents; Dendrobium; Disease Models, Animal; Dose-Response Relationship, D | 2020 |
Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice.
Topics: Animals; Cytokines; Diet, High-Fat; Disease Models, Animal; Edema; Gout; Inflammation; Mice; Mice, I | 2020 |
Antihyperuricemic Effect of Urolithin A in Cultured Hepatocytes and Model Mice.
Topics: Animals; Cell Line; Coumarins; Disease Models, Animal; Gout Suppressants; Hepatocytes; Hyperuricemia | 2020 |
Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway.
Topics: Animals; Disease Models, Animal; Humans; Hyperuricemia; Inflammasomes; Luteolin; Male; Mice; NLR Fam | 2021 |
Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats.
Topics: Animals; Blood Glucose; Butyric Acid; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Female; | 2021 |
IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain.
Topics: Animals; Disease Models, Animal; Gout; Humans; Injections, Intra-Articular; Interleukin-1 Receptor-L | 2020 |
Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Intestinal Mucosa; Liver; Lung Injury; Male; Permeabili | 2020 |
Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis pathway.
Topics: Animals; Biomarkers; Caspase 3; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Hyperuricemia | 2021 |
Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Biomarkers; Disease Models, Animal; Fr | 2020 |
Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
Topics: Animals; Biomarkers; Carrier Proteins; Case-Control Studies; Cytokines; Disease Models, Animal; Dise | 2020 |
Targeting Uric Acid Prevents Brain Injury and Anxiety in a Rat Model of Hemorrhagic Shock.
Topics: Animals; Anxiety; Brain Injuries; Disease Models, Animal; Inflammation Mediators; Male; Random Alloc | 2021 |
Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance.
Topics: Animals; Antioxidants; Biomarkers; Chronic Disease; Creatinine; Disease Models, Animal; Hyperuricemi | 2021 |
A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Autophagy-Related Proteins; Cytokines; Disease Models, | 2020 |
Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Survival; Disease Models, Animal; Glucose; HMGB1 Protein; Inf | 2021 |
Serum and pulmonary uric acid in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Art | 2021 |
Xanthine oxidase inhibitory activity and antihyperuricemic effect of Moringa oleifera Lam. leaf hydrolysate rich in phenolics and peptides.
Topics: Animals; Creatinine; Disease Models, Animal; Flavonoids; Gout Suppressants; Hyperuricemia; Malondial | 2021 |
Modified Simiaowan prevents articular cartilage injury in experimental gouty arthritis by negative regulation of STAT3 pathway.
Topics: Animals; Arthritis, Gouty; Cell Line; Chondrocytes; Cytokines; Disease Models, Animal; Drugs, Chines | 2021 |
Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering.
Topics: Animals; China; Disease Models, Animal; Gout; Histological Techniques; Humans; Male; Middle Aged; Ra | 2021 |
Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Fecal Microb | 2022 |
MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3.
Topics: 3' Untranslated Regions; Animals; Arthritis, Gouty; Binding Sites; Disease Models, Animal; Down-Regu | 2021 |
Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage.
Topics: Administration, Oral; Animals; Cells, Cultured; Disease Models, Animal; DNA, Mitochondrial; Gout; In | 2021 |
Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Creatinine; Cytokines; Disease Models, Animal; Disulfiram; Humans; Mice; | 2022 |
Inosine induces acute hyperuricaemia in rhesus monkey (
Topics: Acute Disease; Allopurinol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Febux | 2021 |
Studies on effect of Tongfengxiaofang in HUM model mice using a UPLC-ESI-Q-TOF/MS metabolomic approach.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Hyperu | 2021 |
Detrimental effects of long-term elevated serum uric acid on cognitive function in rats.
Topics: Animals; Biomarkers; Cognition; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Disease Su | 2021 |
Antiurolithic efficacy of a phenolic rich ethyl acetate fraction of the aerial parts of Aerva lanata (Linn) Juss. ex Schult. in ethylene glycol induced urolithic rats.
Topics: Amaranthaceae; Animals; Calcium; Disease Models, Animal; Flavonoids; Hydrogen-Ion Concentration; Kid | 2021 |
Prolonged Changes in Hepatic Mitochondrial Activity and Insulin Sensitivity by High Fructose Intake in Adolescent Rats.
Topics: Alanine Transaminase; Animals; Body Composition; Ceramides; Diet, Carbohydrate Loading; Disease Mode | 2021 |
Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway.
Topics: Allopurinol; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoplasmic | 2021 |
Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro.
Topics: Acute Disease; Animals; Arthritis, Gouty; Disease Models, Animal; Gout; Humans; Inflammation; Interl | 2021 |
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
Topics: Abietanes; AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Female; Furans | 2021 |
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Topics: Animals; Blood Glucose; Body Weight; CARD Signaling Adaptor Proteins; Caspase 1; Chemokine CCL2; Cyt | 2021 |
Effect of Carnosine on the Course of Experimental Urate Nephrolithiasis.
Topics: Animals; Antioxidants; Carnosine; Disease Models, Animal; Disease Progression; Free Radicals; Kidney | 2021 |
Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Intra-Art | 2021 |
Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis; Diclofenac; Dis | 2021 |
Ameliorative effect and mechanism of Yi-Suan-Cha against hyperuricemia in rats.
Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood Ur | 2021 |
Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model.
Topics: Animals; Berberine; Disease Models, Animal; Hyperuricemia; Kidney; Kidney Diseases; Male; Mice; Mole | 2021 |
The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation.
Topics: Animals; Anserine; Dietary Supplements; Disease Models, Animal; Feces; Functional Food; Gastrointest | 2021 |
Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Actins; Albuminuria; Animals; Blood Pressure; Cyclic N-Oxides; Deoxygua | 2017 |
Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Carrageenan; Disease Model | 2017 |
Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Chromatography, High Pressure Liquid; Disease M | 2017 |
Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Disease Models, Animal; H | 2017 |
Pharmacologic targeting ERK1/2 attenuates the development and progression of hyperuricemic nephropathy in rats.
Topics: Animals; Anion Transport Proteins; Cytokines; Disease Models, Animal; Disease Progression; Fibroblas | 2017 |
Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis.
Topics: Animals; Calcium; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylene Gly | 2017 |
Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Disease Models, Animal; Gout; Granulomatou | 2017 |
Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats.
Topics: Alanine Transaminase; Allopurinol; Animals; Anion Transport Proteins; Aspartate Aminotransferases; C | 2017 |
Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia.
Topics: Animals; Camphanes; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme Inhibitors; Hyperuricemia; | 2017 |
Oral uricase eliminates blood uric acid in the hyperuricemic pig model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Hyperuricemia; Intestinal Mucosa; Male; Nephr | 2017 |
Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Disease Models, Animal; Glucose Transport Prote | 2017 |
Lipidomics to investigate the pharmacologic mechanisms of ginkgo folium in the hyperuricemic rat model.
Topics: Animals; Chromatography, High Pressure Liquid; Computational Biology; Disease Models, Animal; Fructo | 2017 |
Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.
Topics: Animals; Biomarkers; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Creatinine; Diabetes Mellit | 2018 |
Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cyclooxygenase 2; Disease Models, Animal; Humans; Hypertension; Inflammatio | 2017 |
Involvement of xanthine oxidase activity with oxidative and inflammatory renal damage in silver catfish experimentally infected with Streptococcus agalactiae: Interplay with reactive oxygen species and nitric oxide.
Topics: Animals; Brazil; Catfishes; Disease Models, Animal; Fisheries; Fresh Water; Kidney; Kidney Tubules; | 2017 |
Does long-term androgen deficiency lead to metabolic syndrome in middle-aged rats?
Topics: Age Factors; Andropause; Animals; Aromatase Inhibitors; Biomarkers; Blood Glucose; Blood Pressure; C | 2017 |
Cerebrovascular recovery after stroke with individual and combined losartan and captopril treatment of SHRsp.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anim | 2017 |
Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells.
Topics: Adult; Aged; Allergens; Animals; Asthma; Bronchi; Cells, Cultured; Disease Models, Animal; Epithelia | 2017 |
Erding Formula in hyperuricaemia treatment: unfolding traditional Chinese herbal compatibility using modern pharmaceutical approaches.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drugs, Chinese Herbal; Gene E | 2018 |
Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice.
Topics: Animals; Chalcones; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperuricemia; Hypoxan | 2018 |
Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Topics: Adenine; Animals; Biomarkers; Creatinine; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Respons | 2018 |
Effects of experimental periodontitis on the metabolic system in rats with diet-induced obesity (DIO): an analysis of serum biochemical parameters.
Topics: Alanine Transaminase; Alveolar Bone Loss; Animals; Aspartate Aminotransferases; Biomarkers; Blood Gl | 2018 |
Effects of Polygonum cuspidatum on AMPK-FOXO3α Signaling Pathway in Rat Model of Uric Acid-Induced Renal Damage.
Topics: AMP-Activated Protein Kinases; Animals; Chemokine CCL2; Disease Models, Animal; Fallopia japonica; F | 2019 |
Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan.
Topics: Acute Pain; Adjuvants, Immunologic; Animals; Antioxidants; Disease Models, Animal; Flow Cytometry; G | 2018 |
Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation.
Topics: Acute Disease; Administration, Oral; Animals; Anticarcinogenic Agents; Cells, Cultured; Disease Mode | 2018 |
Uric acid upregulates the adiponectin‑adiponectin receptor 1 pathway in renal proximal tubule epithelial cells.
Topics: Adiponectin; Animals; Blood Urea Nitrogen; Cell Line; Cell Survival; Creatinine; Disease Models, Ani | 2018 |
The Pathophysiology of Uric Acid on Renal Diseases.
Topics: Animals; Disease Models, Animal; Hemodynamics; Humans; Hypertension; Hyperuricemia; Kidney Diseases; | 2018 |
Renal Effects of Hyperuricemia.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Glomerular Filtration Rate; Humans; Hypertensi | 2018 |
Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Female; Infarction, Middle Cerebral Artery | 2018 |
Eucalyptus globulus Inhibits Inflammasome-Activated Pro-Inflammatory Responses and Ameliorate Monosodium Urate-Induced Peritonitis in Murine Experimental Model.
Topics: Animals; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cultured; Disease Models, Animal; Eucaly | 2018 |
High Uric Acid Inhibits Cardiomyocyte Viability Through the ERK/P38 Pathway via Oxidative Stress.
Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Disease Models, Animal; Extracellular Signal-Regu | 2018 |
Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats.
Topics: Allopurinol; Animals; Anticonvulsants; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Ele | 2018 |
Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Glucose Transport P | 2018 |
Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Fatty Acids; Gout; Humans; Inflammat | 2018 |
Experimental heat stress nephropathy and liver injury are improved by allopurinol.
Topics: Allopurinol; Animals; Collagen; Disease Models, Animal; Enzyme Inhibitors; Heat Stress Disorders; Ho | 2018 |
Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model.
Topics: Achyranthes; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; ATP Binding Cassette Transporter, | 2018 |
Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease.
Topics: Animals; Antioxidants; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relati | 2018 |
Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Hyperuricemia; Male; Mental Disorde | 2019 |
Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease.
Topics: Adenine; Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Fibroblast | 2018 |
Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9.
Topics: Aesculus; Animals; Anion Transport Proteins; Biomarkers; Blood Urea Nitrogen; Coumarins; Creatinine; | 2018 |
Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aldosterone; Animals; Contraceptives, Oral, Com | 2018 |
A model of chronic enthesitis and new bone formation characterized by multimodal imaging.
Topics: Animals; Chronic Disease; Crystallization; Disease Models, Animal; Inflammation; Mice, Inbred BALB C | 2018 |
Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats.
Topics: Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Female; Male; Mec | 2018 |
Hypouricemic and Antioxidant Effects of Soy Vinegar Extracts in Hyperuricemic Mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine max; Hyperu | 2018 |
CXCR1/CXCR2 antagonist G31P inhibits nephritis in a mouse model of uric acid nephropathy.
Topics: Animals; Blood Urea Nitrogen; Chemokine CXCL1; Disease Models, Animal; Humans; Interleukin-8; Kidney | 2018 |
Frontline Science: Reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arthritis, Gouty; Cell Movement; Cell Polari | 2019 |
Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice.
Topics: Animals; Creatinine; Disease Models, Animal; Fruit; Gene Expression Regulation; Hyperuricemia; Liver | 2018 |
Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.
Topics: Adult; Animals; Antioxidants; Area Under Curve; Disease Models, Animal; Endothelial Cells; Female; F | 2018 |
Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate.
Topics: Acute Kidney Injury; Allopurinol; Animals; Disease Models, Animal; Disease Progression; Glycerol; He | 2018 |
Time to reconsider urate: Neuroprotective potential may prevail on cardiovascular risk in animal models and clinical trials.
Topics: Animals; Cardiovascular Diseases; Clinical Trials as Topic; Disease Models, Animal; Humans; Mice, Tr | 2018 |
Production Inhibition and Excretion Promotion of Urate by Fucoidan from
Topics: Adenine; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drug Evaluation, Preclini | 2018 |
Blockage of macrophage migration inhibitory factor (MIF) suppressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling.
Topics: Animals; Cell Dedifferentiation; Cells, Cultured; Disease Models, Animal; Gene Knockdown Techniques; | 2019 |
A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.
Topics: Allopurinol; Animals; Anserine; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughpu | 2019 |
Caspase-(8/3) activation and organ inflammation in a rat model of resuscitated hemorrhagic shock: A role for uric acid.
Topics: Animals; Apoptosis; Biomarkers; Caspases; Disease Models, Animal; Inflammation; Male; Rats; Rats, Wi | 2019 |
Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy.
Topics: Animals; Blueberry Plants; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Fibronectins; | 2019 |
Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug.
Topics: Animals; Antioxidants; Cholesterol, HDL; Cholesterol, LDL; Curcuma; Disease Models, Animal; Drug Del | 2019 |
Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3β/Nrf2/GCLC pathways.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Dros | 2019 |
Interactions between the cecal microbiota and non-alcoholic steatohepatitis using laying hens as the model.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bacteria; Cecum; Chickens; Disease Model | 2019 |
Role of Probiotic Mixture with and Without Green Tea Extract in Prevention of Hepatorenal Syndrome in Rat Model.
Topics: Animals; Antioxidants; Bifidobacterium; C-Reactive Protein; Creatinine; Disease Models, Animal; Fece | 2019 |
Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Female; HL-60 Cells; Humans; Inflammation; Leptin | 2019 |
Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation.
Topics: Animals; Disease Models, Animal; Gout; Inflammation; Interleukin-1beta; Macrophages; Male; Mice; Mic | 2019 |
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
Topics: Adenine; Animals; Antiporters; Cephalexin; Creatinine; Disease Models, Animal; Down-Regulation; Huma | 2019 |
TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid.
Topics: Adipocytes; Adipose Tissue; Animals; Diet, Carbohydrate Loading; Disease Models, Animal; Fructose; H | 2019 |
Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.
Topics: Animals; Antioxidants; Arthritis, Gouty; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Flavo | 2019 |
Inhibition of Hyperuricemia and Gouty Arthritis in BALB/c Mice Using Copper Oxide Nanoparticles.
Topics: Administration, Oral; Animals; Arthritis, Gouty; Copper; Disease Models, Animal; Humans; Hyperuricem | 2020 |
Highly Acylated Anthocyanins from Purple Sweet Potato ( Ipomoea batatas L.) Alleviate Hyperuricemia and Kidney Inflammation in Hyperuricemic Mice: Possible Attenuation Effects on Allopurinol.
Topics: Acylation; Allopurinol; Animals; Anthocyanins; Disease Models, Animal; Enzyme Inhibitors; Humans; Hy | 2019 |
Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis.
Topics: Animals; Caspase 1; Catechin; Disease Models, Animal; DNA, Mitochondrial; Gout; Humans; Inflammasome | 2019 |
Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation.
Topics: Adult; Animals; Body Fluids; Cytokines; Disease Models, Animal; Down-Regulation; Edema; Female; Foot | 2019 |
Monosodium urate crystal interleukin-1β release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation.
Topics: Animals; Arthritis, Gouty; Cells, Cultured; Disease Models, Animal; Female; Interleukin-18; Macropha | 2020 |
Theacrine attenuates myocardial fibrosis after myocardial infarction via the SIRT3/β-catenin/PPARγ pathway in estrogen-deficient mice.
Topics: Administration, Oral; Animals; Apoptosis; beta Catenin; Disease Models, Animal; Echocardiography; Es | 2019 |
Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Caspase 1; Cytokines; Disease | 2019 |
The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair.
Topics: Aged; Animals; Carrier Proteins; Cell Differentiation; Cells, Cultured; Diabetes Mellitus, Type 2; D | 2019 |
Excess Iron Enhances Purine Catabolism Through Activation of Xanthine Oxidase and Impairs Myelination in the Hippocampus of Nursing Piglets.
Topics: Animals; Disease Models, Animal; Enzyme Activation; Female; Gene Expression; Hippocampus; Humans; In | 2019 |
MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Topics: Animals; Base Sequence; Case-Control Studies; Chemokine CCL2; Disease Models, Animal; Gene Expressio | 2019 |
Hypothermia induced by adenosine 5'-monophosphate attenuates early stage injury in an acute gouty arthritis rat model.
Topics: Animals; Ankle Joint; Arthritis, Gouty; Disease Models, Animal; Hyperuricemia; Hypothermia, Induced; | 2013 |
Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury.
Topics: Animals; Carrier Proteins; Caspase 1; Disease Models, Animal; Inflammasomes; Interleukin-18; Interle | 2013 |
What are the key arguments against uric acid as a true risk factor for hypertension?
Topics: Animals; Blood Pressure; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Kidney; Risk F | 2013 |
The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Bronchial Hyperreactivity; Bronchoalveolar L | 2013 |
Anti-nociceptive and anti-edematogenic effects of glibenclamide in a model of acute gouty attack in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dinoprostone; Disease Models, Animal; Glyburide; Gout | 2013 |
Impulsivity is associated with uric acid: evidence from humans and mice.
Topics: Adult; Aged; Animals; Cohort Studies; Disease Models, Animal; Exploratory Behavior; Female; Humans; | 2014 |
Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2014 |
Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats.
Topics: Acute Kidney Injury; Administration, Oral; Animals; Creatinine; Daucus carota; Disease Models, Anima | 2013 |
Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice.
Topics: Age of Onset; Alleles; Animals; Body Weight; Cystatins; Disease Models, Animal; Disease Progression; | 2013 |
Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease.
Topics: Animals; Bombyx; Disease Models, Animal; Mutation; Oxidative Stress; Parkinson Disease; Signal Trans | 2013 |
Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms.
Topics: Animals; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Hyperuricemia; Lipoproteins, L | 2013 |
Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents.
Topics: Acetanilides; Acute Pain; Animals; Arthritis, Gouty; Disease Models, Animal; Hydrogen Peroxide; Infl | 2013 |
Nephroprotective effects of Isaria felina in rats with adenine-induced chronic renal failure.
Topics: Adenine; Animals; Ascomycota; Biological Products; Blood Urea Nitrogen; Cordyceps; Creatinine; Disea | 2013 |
3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout.
Topics: Administration, Oral; Allopurinol; Animals; Antioxidants; Benzaldehydes; Catechols; Cell-Free System | 2013 |
Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Calcium; Creatinine; Disease Models, Animal; L-Lactate Dehydrogenase; | 2013 |
Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes.
Topics: Adult; Aged; Ammonium Chloride; Animals; Biomarkers; Body Mass Index; Case-Control Studies; Diabetes | 2013 |
Participation of the TRPV1 receptor in the development of acute gout attacks.
Topics: Acute Disease; Anilides; Animals; Arthralgia; Cinnamates; Disease Models, Animal; Gout; Inflammation | 2014 |
Involvement of progesterone receptors in ascorbic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Rel | 2014 |
Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate.
Topics: Animals; Base Sequence; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; DNA Primers; Hypert | 2014 |
High-density lipoproteins inhibit urate crystal-induced inflammation in mice.
Topics: Animals; Back; Chemokine CCL2; Chemokine CXCL1; Disease Models, Animal; Gout; Inflammation; Interleu | 2015 |
Fructokinase activity mediates dehydration-induced renal injury.
Topics: Aldehyde Reductase; Animals; Blood Pressure; Dehydration; Disease Models, Animal; Fructokinases; Kid | 2014 |
Betaine reduces serum uric acid levels and improves kidney function in hyperuricemic mice.
Topics: Acetylglucosaminidase; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding | 2014 |
Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
Topics: Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Gout; Gout Suppressants; Hy | 2014 |
Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout.
Topics: Adult; Aged; Aged, 80 and over; Animals; Calgranulin A; Calgranulin B; Cells, Cultured; Crystallizat | 2014 |
[Effect of Zajdela ascite hepatoma growth on the extracellular antioxidant system of tumor bearer].
Topics: Animals; Antioxidants; Ascites; Carcinoma, Hepatocellular; Ceruloplasmin; Disease Models, Animal; Li | 2013 |
[Effect of jianpihuashi decoction on rats with hyperuricemia].
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drug Combinations; Dr | 2013 |
Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Hyperuricemia; Male; Mice; Uric Acid | 2013 |
Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.
Topics: Adaptive Immunity; Allergens; Animals; Bromelains; Cytokines; Disease Models, Animal; Enzyme-Linked | 2014 |
Heatstroke model for desert dry-heat environment and observed organ damage.
Topics: Animals; Aspartate Aminotransferases; Blood Gas Analysis; Blood Pressure; Body Temperature; Creatine | 2014 |
Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease.
Topics: Allopurinol; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Enzym | 2014 |
High uric acid directly inhibits insulin signalling and induces insulin resistance.
Topics: Acetylcysteine; Animals; Antioxidants; Disease Models, Animal; Glucose Intolerance; Hep G2 Cells; Hu | 2014 |
The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats.
Topics: Animals; Disease Models, Animal; Euonymus; Formaldehyde; Gardenia; Gout; Hyperuricemia; Nociception; | 2014 |
Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Glycosides; Hype | 2014 |
The anti-inflammatory and antioxidant effects of pravastatin and nebivolol in rat aorta.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Aorta; Ceruloplasmin; Cholesterol; Coronary Artery | 2014 |
[Effect of compound qingqin liquid on the expression of toll-like receptor in the renal tissue of rats with urate nephropathy].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Kidney; Kidney Diseases; Male; Rats; Rats, S | 2014 |
Effects of Smilaxchinoside A and Smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Glucose Transport Proteins, Facilitative; Gl | 2014 |
[Effect of compound qingqin liquid on the expression levels of ang II and COX-2 mRNA transcription and protein expression in the renal tissue of uric acid nephropathy rats: an experimental study].
Topics: Angiotensin II; Animals; Cyclooxygenase 2; Disease Models, Animal; Drugs, Chinese Herbal; Kidney; Ki | 2014 |
Methylene blue attenuates ischemia--reperfusion injury in lung transplantation.
Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cold Ischemia; Cytokines; Disease Models, Anima | 2014 |
Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia.
Topics: Advanced Oxidation Protein Products; Allopurinol; Animals; Antigens, CD34; Biomarkers; Bone Marrow; | 2014 |
Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice.
Topics: Animals; Creatinine; Dioscorea; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regul | 2014 |
Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Glucose Transpor | 2014 |
Effects of chicory inulin on serum metabolites of uric acid, lipids, glucose, and abdominal fat deposition in quails induced by purine-rich diets.
Topics: Abdominal Fat; Acetyl-CoA Carboxylase; Animals; Blood Glucose; Cichorium intybus; Diet; Disease Mode | 2014 |
Uric acid promotes chemokine and adhesion molecule production in vascular endothelium via nuclear factor-kappa B signaling.
Topics: Animals; Atherosclerosis; Cell Adhesion; Cell Adhesion Molecules; Cell Survival; Chemokine CCL2; Che | 2015 |
Effects of uric acid on hearts of rats with chronic kidney disease.
Topics: Allopurinol; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Gout Suppressants; Heart | 2014 |
Study on the anti-gout activity of chlorogenic acid: improvement on hyperuricemia and gouty inflammation.
Topics: Animals; Chlorogenic Acid; Cytokines; Disease Models, Animal; Gout; Gout Suppressants; Hyperuricemia | 2014 |
The effect of resveratrol on the recurrent attacks of gouty arthritis.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Female; Kidney; Male; Mice; Mice, Inbred C57BL; R | 2016 |
Uric acid promotes left ventricular diastolic dysfunction in mice fed a Western diet.
Topics: Allopurinol; Animals; Biomarkers; Diet, Western; Dietary Fats; Dietary Sucrose; Disease Models, Anim | 2015 |
Relationship between serum uric Acid and bone mineral density in the general population and in rats with experimental hyperuricemia.
Topics: Adult; Animals; Bone Density; Disease Models, Animal; Female; Humans; Hyperuricemia; Male; Middle Ag | 2015 |
Effects of Xie-Zhuo-Chu-Bi-Fang on miR-34a and URAT1 and their relationship in hyperuricemic mice.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Gout Suppressant | 2015 |
The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity.
Topics: Animals; Creatinine; Cyclosporine; Disease Models, Animal; Glutathione; Glutathione Disulfide; Kidne | 2014 |
Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model.
Topics: Animals; Ankle; Ankle Joint; Anthozoa; Anti-Inflammatory Agents; Arthritis, Gouty; Biological Produc | 2015 |
Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds.
Topics: Adult; Animals; Carrier Proteins; Cohort Studies; Disease Models, Animal; Female; Gene Knockdown Tec | 2015 |
Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals.
Topics: Animals; Antioxidants; Case-Control Studies; Cell Line; Disease Models, Animal; Female; Gene Express | 2015 |
Comprehensive metabolomics identifies the alarmin uric acid as a critical signal for the induction of peanut allergy.
Topics: Alarmins; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry | 2015 |
Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy.
Topics: Animals; Carrier Proteins; Cell Line; Chemokine CXCL12; Coculture Techniques; Diabetes Mellitus, Typ | 2015 |
Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in gout.
Topics: Acetanilides; Animals; Cytokines; Disease Models, Animal; Gout; Inflammation; Mice; Mice, Knockout; | 2015 |
Synergistic protective effects of ceftriaxone and ascorbic acid against subacute deltamethrin-induced nephrotoxicity in rats.
Topics: Acetylcholinesterase; Animals; Antioxidants; Ascorbic Acid; Ceftriaxone; Creatinine; Disease Models, | 2015 |
Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation.
Topics: Administration, Intranasal; Animals; Antigens, Dermatophagoides; Apoptosis Regulatory Proteins; Calc | 2015 |
Activation of peripheral KCNQ channels relieves gout pain.
Topics: Action Potentials; Animals; Animals, Newborn; Arthritis; Benzbromarone; Cells, Cultured; CHO Cells; | 2015 |
Anti-hyperuricemic and nephroprotective effects of rhein in hyperuricemic mice.
Topics: Animals; Anthraquinones; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drugs, Chinese Her | 2015 |
Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy.
Topics: Allopurinol; Animals; Anion Transport Proteins; Cell Line; Disease Models, Animal; Endocytosis; Intr | 2015 |
[Hypouricemic effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma].
Topics: Animals; Dioscorea; Disease Models, Animal; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Plant Extra | 2015 |
Effect of Potassium Citrate on Calcium Phosphate Stones in a Model of Hypercalciuria.
Topics: Animals; Calcium; Calcium Oxalate; Calcium Phosphates; Calcium, Dietary; Citric Acid; Disease Models | 2015 |
Effect of chronic khat (Catha edulis, Forsk) use on outcome of Plasmodium berghei ANKA infection in Swiss albino mice.
Topics: Animals; Body Temperature; Brain; C-Reactive Protein; Catha; Disease Models, Animal; Female; Hemoglo | 2015 |
Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency.
Topics: Analysis of Variance; Animals; Cardiac Output; Disease Models, Animal; Hyperuricemia; Male; Mesenter | 2015 |
[Regulatory effect of leonurus extracts on hyperuricemia in rats].
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Down-Regulation; Gene | 2014 |
A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout.
Topics: Animals; Cell Movement; Chemokine CXCL1; Disease Models, Animal; Fatty Acids, Volatile; Gout; Hypera | 2015 |
[Anti-hyperuricemia effect and mechanism of polydatin in mice].
Topics: Animals; Disease Models, Animal; Glucosides; Hyperuricemia; Kidney; Mice; Stilbenes; Uric Acid | 2014 |
Effect of sodium alginate addition to resveratrol on acute gouty arthritis.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Chemokine CXCL10; Colc | 2015 |
Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.
Topics: alpha-Glucosidases; Animals; Apigenin; Disease Models, Animal; Drug Evaluation, Preclinical; Flavono | 2015 |
Urate synthesis and oxidative stress in phenytoin hepatotoxicity: the role of antioxidant vitamins.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotec | 2014 |
Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice.
Topics: Allopurinol; Animals; Creatinine; Disease Models, Animal; Drug Synergism; Glucose Transport Proteins | 2015 |
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Topics: Adenosine Triphosphate; Adjuvants, Pharmaceutic; Allopurinol; Animals; Antimetabolites; Cells, Cultu | 2015 |
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice.
Topics: Aldehydes; Allopurinol; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Interleu | 2015 |
Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation.
Topics: Animals; Calcium; Carrier Proteins; Catechin; Disease Models, Animal; Free Radical Scavengers; Galli | 2015 |
Therapy: New fusion protein reduces IL-1-mediated inflammation.
Topics: alpha 1-Antitrypsin; Animals; Arthritis, Gouty; Disease Models, Animal; Fatty Acids; Immunoglobulin | 2015 |
Oral treatment with Bifidobacterium longum 51A reduced inflammation in a murine experimental model of gout.
Topics: Administration, Oral; Animals; Bifidobacterium; Cytokines; Disease Models, Animal; Gout; Gout Suppre | 2015 |
Nanosomal Microassemblies for Highly Efficient and Safe Delivery of Therapeutic Enzymes.
Topics: Animals; Antibodies; Biocatalysis; Disease Models, Animal; Drug Carriers; Enzyme-Linked Immunosorben | 2015 |
Development of a model to induce transient synovitis and lameness in the hip joint of dogs.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Dog Diseases; Dogs; Female; Gait; Injectio | 2015 |
[The Xanthine Oxidase Inhibitory Activity and Hypouricemic Effects of Crude Drugs Obtained from the Silkworm in Mice].
Topics: Administration, Oral; Animals; Biological Products; Biomarkers; Blood Pressure; Bombyx; Chromatograp | 2015 |
Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout.
Topics: Animals; Disease Models, Animal; Gout; Hyperalgesia; Inflammation; Interleukin-1beta; Knee Joint; Ma | 2016 |
Uric acid enhances the antitumor immunity of dendritic cell-based vaccine.
Topics: Adjuvants, Immunologic; Adoptive Transfer; Animals; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cyt | 2015 |
Losartan alleviates hyperuricemia-induced atherosclerosis in a rabbit model.
Topics: Animals; Antihypertensive Agents; Aorta; Atherosclerosis; Blotting, Western; Disease Models, Animal; | 2015 |
[The Pharmacokinetics and Pharmacodynamics of Intravenous Uricase Multivesicular Liposomes].
Topics: Administration, Intravenous; Animals; Area Under Curve; Biological Availability; Disease Models, Ani | 2015 |
Antioxidative phytochemicals from Rhododendron oldhamii Maxim. leaf extracts reduce serum uric acid levels in potassium oxonate-induced hyperuricemic mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Gout Suppressants; Hyperuricemia; Kidney; Male; Mice; | 2015 |
Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid | 2016 |
Effects of Acute Stroke Serum on Non-Ischemic Cerebral and Mesenteric Vascular Function.
Topics: Acetylcholine; Aged; Animals; C-Reactive Protein; Cerebral Arteries; Dinoprost; Disease Models, Anim | 2016 |
Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Butanols; Disease Models, Animal; Hyperuricemia; Ma | 2016 |
High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo.
Topics: Animals; Cell Membrane; Cells, Cultured; Disease Models, Animal; Gene Expression; Glucose; Glucose T | 2016 |
Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy.
Topics: Animals; Cell Membrane; Crystallization; Disease Models, Animal; Endocytosis; Folic Acid; Kidney Dis | 2016 |
Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout.
Topics: Acute Disease; Animals; Disease Models, Animal; Female; Gout; Humans; Inflammation; Injections; Inte | 2016 |
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity.
Topics: Administration, Oral; Animals; Biomarkers; Biotransformation; Disease Models, Animal; Dose-Response | 2016 |
Maternal fructose drives placental uric acid production leading to adverse fetal outcomes.
Topics: Allopurinol; AMP Deaminase; Animals; Disease Models, Animal; Female; Fetal Growth Retardation; Fruct | 2016 |
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B | 2016 |
Amelioration of anti-tuberculosis drug induced oxidative stress in kidneys by Spirulina fusiformis in a rat model.
Topics: Acute Kidney Injury; Animals; Antioxidants; Antitubercular Agents; Creatinine; Disease Models, Anima | 2016 |
Traditional Chinese Medicine Formula "Xiaofeng granules" suppressed gouty arthritis animal models and inhibited the proteoglycan degradation on chondrocytes induced by monosodium urate.
Topics: ADAMTS4 Protein; Animals; Arthritis, Gouty; Cells, Cultured; Chondrocytes; Cytokines; Disease Models | 2016 |
Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators.
Topics: Acute Disease; Animals; Antioxidants; Arthritis, Gouty; Cyclooxygenase 2; Cytokines; Diet; Disease M | 2016 |
Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-'Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cardiova | 2016 |
Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Biomarkers; Cytokines; Disease Mo | 2016 |
Combined oral contraceptive-induced hypertension is accompanied by endothelial dysfunction and upregulated intrarenal angiotensin II type 1 receptor gene expression.
Topics: Animals; Blood Pressure; Contraceptives, Oral, Combined; Disease Models, Animal; Dose-Response Relat | 2016 |
Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism.
Topics: Adaptive Immunity; Allergens; Allopurinol; Animals; Antigen Presentation; Asthma; Cytokines; Disease | 2016 |
Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Curcumin; Disease Models, Animal; Enz | 2016 |
Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice.
Topics: Acetates; Animals; Apoptosis; Caspases; Crystallization; Diet, High-Fat; Dietary Fiber; Disease Mode | 2017 |
Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.
Topics: Allergens; Alternaria; Animals; Asthma; Disease Models, Animal; Lung; Male; Membrane Proteins; Mice, | 2017 |
Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Et | 2016 |
Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Line; Cell Proliferation; Cell Survival; Disease Mod | 2017 |
Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow | 2016 |
Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction.
Topics: Animals; Chorioamnionitis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fetal | 2017 |
Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury.
Topics: Acute Kidney Injury; Allopurinol; Animals; Creatinine; Disease Models, Animal; Gout Suppressants; Ma | 2016 |
Reply to "Neutrophils are not required for resolution of acute gouty arthritis in mice".
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Mice; Neutrophils; Uric Acid | 2016 |
Neutrophils are not required for resolution of acute gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Mice; Neutrophils; Uric Acid | 2016 |
Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout.
Topics: Administration, Oral; Animals; Biomarkers; Caffeic Acids; CARD Signaling Adaptor Proteins; Disease M | 2016 |
Nephroprotective efficacy of ceftriaxone against cisplatin-induced subchronic renal fibrosis in rats.
Topics: Actins; Animals; Biomarkers; Bromodeoxyuridine; Ceftriaxone; Cell Proliferation; Cisplatin; Creatini | 2017 |
Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Caco-2 Cells; Calcimimetic Agents; | 2017 |
Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Creatinine; Cytoprotection; Dipyridamole; Disease Mod | 2017 |
Annexin A1 promotes timely resolution of inflammation in murine gout.
Topics: Animals; Annexin A1; Anti-Inflammatory Agents; Antibodies, Blocking; Apoptosis; Cell Movement; Disea | 2017 |
Oral delivery of allopurinol niosomes in treatment of gout in animal model.
Topics: Administration, Oral; Allopurinol; Animals; Disease Models, Animal; Drug Delivery Systems; Gout; Hex | 2017 |
Soluble Uric Acid Activates the NLRP3 Inflammasome.
Topics: Animals; Caspase 1; Cells, Cultured; Disease Models, Animal; Fibrosis; Inflammasomes; Interleukin-1b | 2017 |
A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice.
Topics: Animals; Antibodies, Fungal; Colitis; Colony Count, Microbial; Disease Models, Animal; Disease Progr | 2017 |
Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Disease Models | 2017 |
Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis).
Topics: Acute Disease; Allopurinol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzym | 2017 |
Gout in the spotlight.
Topics: Animals; Disease Models, Animal; Gout; Humans; Mice; Uric Acid | 2008 |
Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency.
Topics: Aldosterone; Animal Feed; Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Hyperten | 2008 |
Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure.
Topics: Adult; Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetra | 2009 |
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Benzofurans; Depsid | 2008 |
Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor.
Topics: Allopurinol; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomyopathies; Dis | 2008 |
Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction.
Topics: Animals; Diaphragm; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Hypoxan | 2009 |
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensins; Animals; Cells, Cultured; Disease Models | 2008 |
Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout.
Topics: Acute Disease; Animals; Crystallization; Disease Models, Animal; Gout; Interleukin-1beta; Interleuki | 2009 |
Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Cardiotonic Ag | 2009 |
Inhibition of monosodium urate crystal-induced inflammation by withaferin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ergosterol; | 2008 |
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.
Topics: Allopurinol; Animals; Biomarkers; Bleomycin; Bronchoalveolar Lavage Fluid; Carrier Proteins; Disease | 2009 |
Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gout; Homeostasis; Hyperuricemia; Hypogl | 2009 |
Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents.
Topics: Animals; Disease Models, Animal; Drug Synergism; Gout Suppressants; Hyperuricemia; Inhibitory Concen | 2009 |
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice.
Topics: Albuminuria; Allopurinol; Animals; Blood Pressure; Blood Urea Nitrogen; Cell Line; Diabetes Mellitus | 2009 |
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Gouty; Biomarkers; Colchicine; Cytokines; Disease Model | 2009 |
Generation of mice with a conditional allele for G6pc.
Topics: Alleles; Animals; Blood Glucose; Cholesterol; Disease Models, Animal; DNA Primers; Gene Components; | 2009 |
Hepcidin in acute iron toxicity.
Topics: Acute Disease; Alanine Transaminase; Animals; Antimicrobial Cationic Peptides; Aspartate Aminotransf | 2009 |
[Effects of ethyl pyruvate on injuries of sepsis in mice].
Topics: Alkaline Phosphatase; Animals; Disease Models, Animal; Intestines; Lactic Acid; Lung; Male; Mice; Py | 2009 |
Identification of dairy fractions with anti-inflammatory properties in models of acute gout.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caseins; Crystallization; Dairy Pro | 2010 |
Identification of dairy fractions with anti-inflammatory properties in models of acute gout.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caseins; Crystallization; Dairy Pro | 2010 |
Identification of dairy fractions with anti-inflammatory properties in models of acute gout.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caseins; Crystallization; Dairy Pro | 2010 |
Identification of dairy fractions with anti-inflammatory properties in models of acute gout.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caseins; Crystallization; Dairy Pro | 2010 |
The effects of hyperoxia exposure on lung function and pulmonary surfactant in a rat model of acute lung injury.
Topics: Acute Lung Injury; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Bronchoalveolar Lavage Fluid; D | 2009 |
Abdominal fat accumulation with hyperuricemia and hypercholesterolemia quail model induced by high fat diet.
Topics: Abdominal Fat; Animals; Body Weight; Coturnix; Dietary Fats; Disease Models, Animal; Hypercholestero | 2009 |
[Cardioprotective effects of activation of ATP-sensitive potassium channels in experiments in vivo: influence on blood biochemical parameters following ischemia-reperfusion of the myocardium].
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Dogs; Free Radicals; Hemodynamics | 2009 |
Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia.
Topics: Aldehyde Reductase; Amino Acid Sequence; Animals; Bartter Syndrome; Biomarkers; Blood Pressure; Body | 2010 |
Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung.
Topics: Adenosine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Disease Mod | 2010 |
Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells.
Topics: Animals; Blotting, Western; Cell Line; Disease Models, Animal; Epithelial Cells; Extracellular Matri | 2010 |
A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Gouty; Benzodi | 2011 |
Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Area Under Curve; Behavior, Animal; Diazepam; Disea | 2010 |
Hypouricemic therapy: a novel potential therapeutic option for nonalcoholic fatty liver disease.
Topics: Animals; Dietary Fats; Disease Models, Animal; Fatty Liver; Gerbillinae; Humans; Uric Acid | 2010 |
Assessment of uric acid and lipid peroxidation in serum and urine after hypoxia-ischemia neonatal in rats.
Topics: Albumins; Animals; Animals, Newborn; Disease Models, Animal; Hypoxia; Ischemia; Lipid Peroxidation; | 2011 |
Oral microencapsulated live Saccharomyces cerevisiae cells for use in renal failure uremia: preparation and in vivo analysis.
Topics: Administration, Oral; Alginates; Animals; Calcium; Capsules; Creatinine; Disease Models, Animal; Gas | 2010 |
[Study on extracting process of ethanol extract with hypouricemic effect from rhizoma alismatis].
Topics: Alismataceae; Animals; Chemical Fractionation; Disease Models, Animal; Ethanol; Humans; Hyperuricemi | 2010 |
Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.
Topics: Allopurinol; Animals; Aorta; Arginine; Benzbromarone; Biological Transport; Blood Pressure; Cationic | 2011 |
Uric acid and cardiovascular risk in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cardiovascular Diseases; Disease Models, Animal; Humans; Hypertensio | 2011 |
3,5,2',4'-Tetrahydroxychalcone, a new non-purine xanthine oxidase inhibitor.
Topics: Animals; Chalcone; Chalcones; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhib | 2011 |
Interleukin-1β activation during acute joint inflammation: a limited role for the NLRP3 inflammasome in vivo.
Topics: Animals; Apoptosis Regulatory Proteins; Arthritis; CARD Signaling Adaptor Proteins; Carrier Proteins | 2011 |
Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice.
Topics: Allopurinol; Animals; Anthocyanins; Disease Models, Animal; Hyperuricemia; Ipomoea batatas; Male; Mi | 2011 |
Effect of acupuncture on rats with acute gouty arthritis inflammation: a metabonomic method for profiling of both urine and plasma metabolic perturbation.
Topics: Acupuncture Therapy; Animals; Arthritis, Gouty; Chromatography, High Pressure Liquid; Disease Models | 2011 |
[Disorders of uric acid metabolism in rats with fructose-induced experimental insulin resistance syndrome].
Topics: 5'-Nucleotidase; Adenosine Deaminase; Animals; Blood Glucose; Disease Models, Animal; Female; Fructo | 2011 |
Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout.
Topics: Animals; Blotting, Western; Cell Differentiation; Disease Models, Animal; Flow Cytometry; Gout; Infl | 2011 |
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged B | 2011 |
The effect of montelukast in a model of gouty arthritis induced by sodium monourate crystals.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Cell Migration Assays, | 2011 |
Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats.
Topics: Animals; Blood Urea Nitrogen; Connective Tissue Growth Factor; Creatinine; Dinoprostone; Disease Mod | 2011 |
Effect of vitamin E therapy on serum uric acid in DOCA-salt-treated rats.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Hypertension; Injections, Sub | 2011 |
Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia.
Topics: Allopurinol; Analysis of Variance; Animals; Antioxidants; Atrasentan; Biomarkers; Cyclic N-Oxides; D | 2011 |
Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis.
Topics: Acetaminophen; Animals; Antioxidants; Creatine; Disease Models, Animal; Ethanol; Kidney Diseases; Ma | 2011 |
Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Carrier Proteins; Creatinine; Disease Models, Animal; Gen | 2012 |
Uric acid and chronic kidney disease: new understanding of an old problem.
Topics: Animals; Chronic Disease; Disease Models, Animal; Humans; Kidney Diseases; Uric Acid | 2011 |
Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease.
Topics: Allantoin; Animals; Biomarkers; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Hippur | 2012 |
Rabbit model of primary hyperparathyroidism induced by high-phosphate diet.
Topics: Animals; Blood Urea Nitrogen; Calcium; Creatinine; Disease Models, Animal; Histocytochemistry; Hyper | 2012 |
Bradykinin receptor 2 extends inflammatory cell recruitment in a model of acute gouty arthritis.
Topics: Acute Disease; Animals; Arthritis, Gouty; Bradykinin; Bradykinin B2 Receptor Antagonists; Cell Movem | 2011 |
[Exploration on the establishment of animal models for gouty nephropathy complicated with chronic renal failure].
Topics: Animals; Disease Models, Animal; Gout; Hyperuricemia; Kidney Failure, Chronic; Male; Rats; Rats, Wis | 2011 |
P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals.
Topics: Animals; Antioxidants; Cell Line; Cytokines; Disease Models, Animal; Gout; Humans; Hyperuricemia; In | 2012 |
Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout.
Topics: Animals; Automation; Biomarkers; Carbon Isotopes; Chromatography, High Pressure Liquid; Disease Mode | 2012 |
Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Exercise; Humans; Inflammation; Lipids; | 2011 |
Supplementation of Nigella sativa fixed and essential oil mediates potassium bromate induced oxidative stress and multiple organ toxicity.
Topics: Animals; Biomarkers; Bromates; Creatine; Disease Models, Animal; Drug Evaluation, Preclinical; Heart | 2012 |
Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats.
Topics: Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Birth Weight; Catalase; Cysteine; Disease Mo | 2012 |
An improved acute gouty arthritis rat model and therapeutic effect of rhizoma Dioscoreae nipponicae on acute gouty arthritis based on the protein-chip methods.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Dioscorea; Disease Models, Anima | 2012 |
Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model.
Topics: Animals; Atrophy; Biomarkers; Blood Urea Nitrogen; Bone Marrow Transplantation; Cell-Derived Micropa | 2012 |
Long-term activation of semicarbazide-sensitive amine oxidase lowers circulating levels of uric acid in diabetic conditions.
Topics: Amine Oxidase (Copper-Containing); Ammonia; Animals; Benzylamines; Blood Glucose; Cell Adhesion Mole | 2012 |
Characterization, efficacy, pharmacokinetics, and biodistribution of 5kDa mPEG modified tetrameric canine uricase variant.
Topics: Animals; Arthritis, Experimental; Biological Availability; Chemistry, Pharmaceutical; Chickens; Dise | 2012 |
Uricase from Bacillus fastidious loaded in alkaline enzymosomes: enhanced biochemical and pharmacological characteristics in hypouricemic rats.
Topics: Animals; Bacillus; Disease Models, Animal; Half-Life; Humans; Hydrogen-Ion Concentration; Hyperurice | 2012 |
Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat.
Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Chemokines; Disease | 2012 |
The effects of phentolamine on fructose-fed rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Glucose; Blood Pressure; Disease Models | 2012 |
Hypouricemic effect of the methanol extract from Prunus mume fruit in mice.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Hype | 2012 |
Reducing effect of mangiferin on serum uric acid levels in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gout; | 2012 |
Preconditioning protects the heart in a prolonged uremic condition.
Topics: Angiotensin II; Animals; Biomarkers; Creatinine; Disease Models, Animal; Ischemic Preconditioning, M | 2012 |
Hyperuricemia and hypertension.
Topics: Adolescent; Animals; Disease Models, Animal; Humans; Hypertension; Hyperuricemia; Rats; Risk Factors | 2012 |
The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Biomarkers, Pharmacological; Disease | 2013 |
Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice.
Topics: Animals; Blood Chemical Analysis; Body Weight; Cyclooxygenase 2; Dinoprostone; Disease Models, Anima | 2013 |
Neutrophil cannibalism triggers transforming growth factor β1 production and self regulation of neutrophil inflammatory function in monosodium urate monohydrate crystal-induced inflammation in mice.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Crystallization; Cytophagocytosis; Disease Models | 2013 |
Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease.
Topics: Actins; Animals; Cadherins; Creatinine; Disease Models, Animal; Epithelial Cells; Hyperuricemia; Kid | 2013 |
Reducing serum uric acid attenuates TGF-β1-induced profibrogenic progression in type 2 diabetic nephropathy.
Topics: Animals; Biomarkers; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Mod | 2012 |
Role of host xanthine oxidase in infection due to enteropathogenic and Shiga-toxigenic Escherichia coli.
Topics: Animals; Bodily Secretions; Cell Line; Disease Models, Animal; Enteropathogenic Escherichia coli; Es | 2013 |
Inhibition of UV-induced uric acid production using allopurinol prevents suppression of the contact hypersensitivity response.
Topics: Allopurinol; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Protei | 2013 |
Monosodium urate monohydrate crystal-induced inflammation in vivo: quantitative histomorphometric analysis of cellular events.
Topics: Animals; Cell Count; Crystallization; Disease Models, Animal; Exudates and Transudates; Fibroblasts; | 2002 |
Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endotoxemia; Kidney; Lipid Peroxi | 2002 |
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies.
Topics: Animals; Biological Availability; Candida; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-R | 2002 |
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies.
Topics: Animals; Biological Availability; Candida; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-R | 2002 |
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies.
Topics: Animals; Biological Availability; Candida; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-R | 2002 |
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies.
Topics: Animals; Biological Availability; Candida; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-R | 2002 |
Mild hyperuricemia induces glomerular hypertension in normal rats.
Topics: Animals; Arterioles; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Hypertrophy; Kidne | 2002 |
Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis.
Topics: Adrenocorticotropic Hormone; Animals; Arthritis, Gouty; Disease Models, Animal; gamma-MSH; Knee Join | 2002 |
Molybdenum cofactor-deficient mice resemble the phenotype of human patients.
Topics: Animals; Carbon-Carbon Lyases; Coenzymes; Disease Models, Animal; Humans; Metalloproteins; Mice; Mic | 2002 |
Evaluation of a rat model of preeclampsia for HELLP syndrome characteristics.
Topics: Animals; Aorta; Arteries; Blood Cell Count; Blood Pressure; Constriction; Creatinine; Disease Models | 2003 |
Intra-articular corticosteroid preparations: different characteristics and their effect during inflammation induced by monosodium urate crystals in the rat subcutaneous air pouch.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Betamethasone; Crystallization; Delayed-Action | 2003 |
Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis.
Topics: Acute Disease; Air; Animals; Antibodies; Arthritis, Gouty; Calgranulin A; Calgranulin B; Cell Moveme | 2003 |
Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase.
Topics: Acute Disease; Animals; Arthritis, Gouty; Cell Line, Tumor; Chemokine CXCL2; Chemokines; Crystalliza | 2003 |
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Dose-Response Relati | 2004 |
Substance P immunoreactive nerve fibres in the domestic chick ankle joint before and after acute urate arthritis.
Topics: Animals; Arthralgia; Arthritis; Chickens; Disease Models, Animal; Down-Regulation; Female; Gout; Imm | 2004 |
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Res | 2004 |
A functional immature model of chronic partial ureteral obstruction.
Topics: Animals; Chronic Disease; Disease Models, Animal; Diuresis; Kidney; Male; Proteinuria; Rats; Rats, W | 2004 |
Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.
Topics: Allopurinol; Animals; Antioxidants; Biflavonoids; Catechin; Disease Models, Animal; Dose-Response Re | 2004 |
ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity.
Topics: Animals; Blood-Brain Barrier; Chemotaxis, Leukocyte; Disease Models, Animal; Encephalomyelitis, Auto | 2004 |
Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Chronic Disease; Cyclic GMP; Disease Mod | 2004 |
Disturbances in renal autoregulation and the susceptibility to hypertension-induced chronic kidney disease.
Topics: Aging; Animals; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Fetal Growth Retar | 2004 |
Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia.
Topics: Animals; Antioxidants; Arachidonic Acid; Ascorbic Acid; Brain; Brain Ischemia; Dinoprostone; Disease | 2005 |
[Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats].
Topics: Animals; Anti-Infective Agents; Brazil; Caffeic Acids; China; Coumaric Acids; Disease Models, Animal | 2005 |
[Study of serum uric acid changes after experimental pulmonary thromboembolism in rats].
Topics: Animals; Disease Models, Animal; Lung; Male; Pulmonary Embolism; Random Allocation; Rats; Rats, Spra | 2005 |
Credentials of Spirulina diet on stability and flux related properties on the biomineralization process during oxalate mediated renal calcification in rats.
Topics: Animals; Bacterial Proteins; Biomarkers; Blood Urea Nitrogen; Calcium; Calcium Oxalate; Chromatograp | 2005 |
Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation; Arthritis, Gouty; Bone Mar | 2005 |
Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch.
Topics: Animals; Arthritis, Gouty; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Inflammation; | 2005 |
Heroin affects purine nucleotides catabolism in rats in vivo.
Topics: Adenosine Deaminase; Animals; Brain; Disease Models, Animal; Heroin; Heroin Dependence; Male; Purine | 2006 |
Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats.
Topics: Administration, Oral; Allopurinol; Animals; Chrysanthemum; Disease Models, Animal; Dose-Response Rel | 2005 |
Uric acid, a nucleic acid degradation product, down-regulates dsRNA-triggered arthritis.
Topics: Animals; Arthritis, Experimental; Chemotaxis; Chemotaxis, Leukocyte; Disease Models, Animal; Down-Re | 2006 |
Effect of nitric oxide and peroxynitrite on mucociliary transport function of experimental otitis media.
Topics: Animals; Disease Models, Animal; Free Radical Scavengers; Guinea Pigs; Lipopolysaccharides; Mucocili | 2006 |
Gout-associated uric acid crystals activate the NALP3 inflammasome.
Topics: Animals; Calcium Pyrophosphate; Carrier Proteins; Caspase 1; Cell Line; Cells, Cultured; Chondrocalc | 2006 |
Effect and mechanism of total saponin of Dioscorea on animal experimental hyperuricemia.
Topics: Animals; Dioscorea; Disease Models, Animal; Hyperuricemia; Injections, Intraperitoneal; Liver; Male; | 2006 |
The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage.
Topics: Acute Disease; alpha-MSH; Animals; Anti-Inflammatory Agents; Blood Pressure; Carrageenan; Chemokine | 2006 |
Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals.
Topics: Acute Disease; Animals; Antibodies, Blocking; Crystallization; Cytokines; Disease Models, Animal; Do | 2006 |
Decrease in reducing power of aqueous humor originating from glaucomatous rabbits.
Topics: Animals; Aqueous Humor; Ascorbic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2007 |
The effect of L-arginine methyl ester on indices of free radical involvement in a rat model of experimental nephrocalcinosis.
Topics: Animals; Arginine; Blood Urea Nitrogen; Calcium Oxalate; Catalase; Creatinine; Crystallization; Dise | 2006 |
Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice.
Topics: Animals; Antibodies; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; F | 2006 |
Melanocortin 3 receptors control crystal-induced inflammation.
Topics: Animals; Arthritis, Experimental; Arthritis, Gouty; Disease Models, Animal; Gene Expression Regulati | 2006 |
[Leptin protects sepsis-induced renal injury and research for its mechanism].
Topics: Animals; Disease Models, Animal; Kidney; Leptin; Male; Mice; Peroxidase; Random Allocation; Sepsis; | 2006 |
Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine Diphosphate; Ad | 2007 |
The role of uric acid in pediatric hypertension.
Topics: Adolescent; Animals; Disease Models, Animal; Gout Suppressants; Humans; Hypertension; Hyperuricemia; | 2007 |
Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Dinoprostone; Disease Models, Animal; Eleuthero | 2007 |
Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice.
Topics: Animals; Antioxidants; Cecum; Cell Adhesion; Cell Movement; Cytokines; Disease Models, Animal; Ligat | 2007 |
Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice.
Topics: Animals; Antioxidants; Blood Flow Velocity; Brain Injuries; Brain Ischemia; Cell Culture Techniques; | 2007 |
Urate crystals, inflammation, and colchicine.
Topics: Animals; Arthritis, Gouty; Colchicine; Disease Models, Animal; Gout; Gout Suppressants; History, 20t | 2008 |
Plasmodium-induced inflammation by uric acid.
Topics: Animals; Culture Media, Conditioned; Dendritic Cells; Disease Models, Animal; Erythrocytes; Hypoxant | 2008 |
Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Creatinine; Desoxycorticosterone; Disease M | 2008 |
The influence of uric acid treatments on liver glutathione system prevent oxidative damages in experimental autoimmune encephalomyelitis mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Glutathi | 2008 |
IMP dehydrogenase mutants: cell culture model for hyperuricemia.
Topics: Animals; Cell Line; Disease Models, Animal; Gout; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; | 1984 |
Stimulation of secretion of collagenase and prostaglandin E2 by synovial fibroblasts in response to crystals of monosodium urate monohydrate: a model for joint destruction in gout.
Topics: Animals; Crystallization; Dinoprostone; Disease Models, Animal; Fibroblasts; Gout; Microbial Collage | 1981 |
A chick model for impaired renal function.
Topics: Animals; Blood Urea Nitrogen; Chickens; Disease Models, Animal; Kidney; Kidney Diseases; Ligation; M | 1984 |
[The system of active transport of organic acids in the proximal tubules of rats with hereditary retinal degeneration (Campbell strain)].
Topics: Adenosine; Adenosine Monophosphate; Animals; Bile Acids and Salts; Biological Transport, Active; Dis | 1983 |
Increased inflammatory reactivity in newly formed lining tissue.
Topics: Air; Animals; Calcium Pyrophosphate; Carrageenan; Disease Models, Animal; Male; Rats; Rats, Inbred S | 1983 |
Arthritis induced in cat by sodium urate: a possible animal model for tonic pain.
Topics: Animals; Arthritis; Behavior, Animal; Cat Diseases; Cats; Disease Models, Animal; Gait; Injections, | 1984 |
[Changes in the blood uric acid levels in patients with retinitis pigmentosa and in rats with hereditary retinal degeneration].
Topics: Animals; Brain; Disease Models, Animal; Genetic Diseases, Inborn; Genetic Testing; Humans; Liver; Ra | 1982 |
[Hepatic coma - experimental study with swine (part 1)].
Topics: Acetamides; Ammonia; Animals; Creatinine; Disease Models, Animal; Electrolytes; Enzymes; Female; Hep | 1981 |
A micropuncture study of a dietary induced, hyperuricemic model of acute renal failure in the rat.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Hydrostatic Pressure; Kidney; Kidney Tubules; | 1980 |
[Silkworms as a model for human diseases].
Topics: Amino Acids; Animals; Bombyx; Disease Models, Animal; Fatty Acids; Genetic Linkage; Uric Acid | 1980 |
Renal function in rats with acute medullary injury.
Topics: Acute Kidney Injury; Animals; Calcium; Diet; Disease Models, Animal; Glomerular Filtration Rate; Hyd | 1980 |
Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats.
Topics: Administration, Oral; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Gout: questions that still need to be answered.
Topics: Animals; Crystallization; Disease Models, Animal; Gout; Humans; Mice; Mice, Mutant Strains; Synoviti | 1995 |
L-dopa induced increases in brain uric acid in an animal model of Parkinson's disease: a relationship to behavioral activation.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Dopamine; Levodopa; Male; Neurons; Oxidopa | 1994 |
Hypoxanthine, xanthine, and uric acid concentrations in plasma, cerebrospinal fluid, vitreous humor, and urine in piglets subjected to intermittent versus continuous hypoxemia.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Hypoxanthine; Hypoxanthines; Hypo | 1993 |
Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Isoxazoles; Kidney; Liver; Male; | 1994 |
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.
Topics: Allopurinol; Animals; Arthritis, Gouty; Disease Models, Animal; Genes, Lethal; Humans; Kidney Calcul | 1994 |
The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat.
Topics: Animals; Arthritis, Experimental; Capsaicin; Disease Models, Animal; Enflurane; Female; Freund's Adj | 1993 |
Successful prolonged correction of an inborn metabolic defect by heterotopic auxiliary liver transplantation in a dog model.
Topics: Animals; Disease Models, Animal; Dogs; Liver; Liver Function Tests; Liver Transplantation; Metabolis | 1993 |
Antioxidant defenses and its modulation by iron in carrageenan-induced inflammation in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Carrageenan; Deferoxamine; Disease Models, Animal; Granuloma; | 1993 |
Characterization of E-selectin expression, leucocyte traffic and clinical sequelae in urate crystal-induced inflammation: an insight into gout.
Topics: Albumins; Animals; Cell Movement; Disease Models, Animal; E-Selectin; Gout; Leukocytes, Mononuclear; | 1996 |
Inhibition and prevention of monosodium urate monohydrate crystal-induced acute inflammation in vivo by transforming growth factor beta1.
Topics: Acute Disease; Animals; Antibodies, Anti-Idiotypic; Disease Models, Animal; Dose-Response Relationsh | 1996 |
Endogenous analgesia in the chicken.
Topics: Analgesia; Animals; Ankle Joint; Behavior, Animal; Chickens; Disease Models, Animal; Gout; Time Fact | 1995 |
Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Azepines; C-React | 1996 |
Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Urea Nitrogen; Cell Count; Creatinine; Diabetes | 1996 |
Altered arachidonic acid metabolism in urate crystal induced inflammation.
Topics: Animals; Arachidonic Acid; Arthritis, Gouty; Crystallization; Disease Models, Animal; Eicosanoids; F | 1997 |
Pain-related behaviour following sodium urate arthritis is expressed in decerebrate chickens.
Topics: Animals; Arthritis; Behavior, Animal; Chickens; Decerebrate State; Disease Models, Animal; Pain; Tel | 1997 |
Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide.
Topics: Aged; Analysis of Variance; Animals; Antioxidants; Aqueous Humor; Ascorbic Acid; Cataract; Chromatog | 1998 |
Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria?
Topics: Animals; Brain; Dihydroxyphenylalanine; Disease Models, Animal; Female; Malaria, Cerebral; Membrane | 1999 |
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise | 1998 |
[Uric acid as a scavenger in oxidative stress].
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Free Rad | 1999 |
Rehabilitating role of glutathione ester on cisplatin induced nephrotoxicity.
Topics: Animals; Antineoplastic Agents; Biomarkers; Cisplatin; Creatinine; Disease Models, Animal; Esters; G | 1999 |
[The central mechanisms regulating the blood circulation in hyperuricemia].
Topics: Adenosine; Animals; Blood Circulation; Brain; Brain Chemistry; Cyclic AMP; Cyclic GMP; Disease Model | 1999 |
Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease I: study using a rat model of hyperuricemia.
Topics: Animals; Benzothiazoles; Disease Models, Animal; Inflammatory Bowel Diseases; Inulin; Kidney Tubules | 1999 |
Evaluation of intraarticular opioid analgesia for the relief of articular pain in the domestic fowl.
Topics: Analgesia; Analgesics; Animals; Arthritis, Gouty; Buprenorphine; Chickens; Disease Models, Animal; F | 1999 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Expe | 2000 |
[A chronic hyperimmunocomplex process and its interrelationship with free radical-generating systems].
Topics: Animals; Antigen-Antibody Complex; Chronic Disease; Cyclic AMP; Cyclic GMP; Disease Models, Animal; | 2000 |
Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl(4) poisoning?
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Carbon Tetrachloride Poisoning; Disease Models, An | 2000 |
Purine-induced alterations of dopamine metabolism in rat pheochromocytoma PC12 cells.
Topics: Adenine; Adenosine; Animals; Disease Models, Animal; Dopamine; Guanine; Guanosine; Hypoxanthine; Neo | 2000 |
Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; F | 2000 |
Analysis of antinociceptive effects of flurbiprofen enantiomers in a rat model of arthritic pain.
Topics: Analgesics; Animals; Area Under Curve; Arthritis; Disease Models, Animal; Dose-Response Relationship | 2000 |
Blood purine and energy status in rats with colitis.
Topics: Acetic Acid; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anim | 2001 |
Residual oil fly ash inhalation in guinea pigs: influence of absorbate and glutathione depletion.
Topics: Administration, Inhalation; Air Pollutants; Animals; Antioxidants; Ascorbic Acid; Ascorbic Acid Defi | 2001 |
Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.
Topics: Animals; Body Water; Diabetes Insipidus; Disease Models, Animal; Gout; Humans; Kidney Concentrating | 2001 |
The effect of allopurinol on focal cerebral ischaemia: an experimental study in rabbits.
Topics: Allopurinol; Animals; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Chromatography, High Pressu | 2001 |
Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations.
Topics: Animals; Disease Models, Animal; Humans; Male; Meningitis, Pneumococcal; Protective Agents; Rats; Ra | 2001 |
Physiological characteristics of various experimental models for the study of disorders in purine metabolism.
Topics: Acidosis; Alkalosis; Allopurinol; Animals; Cholesterol; Disease Models, Animal; Diuresis; Fructose; | 1977 |
The defect of uric acid metabolism in Eck-fistula rats.
Topics: Allantoin; Animals; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Disease Models, Animal; Glom | 1977 |
An inheritable hyperlipidemic rabbit.
Topics: Animals; Cholesterol; Disease Models, Animal; Humans; Hyperlipidemias; Lipoproteins, LDL; Lipoprotei | 1976 |
Hyperuricemic nephropathy: pathologic features and factors influencing urate deposition.
Topics: Acute Kidney Injury; Animals; Binding Sites; Crystallization; Disease Models, Animal; Diuretics; Gou | 1975 |
[Pharmacological studies on carprofen, a new non-steroidal anti-inflammatory drug, in animals (author's transl)].
Topics: Adrenal Cortex; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents | 1977 |
High steady-state levels of uric acid produced in rats by dietary training and potassium oxonate.
Topics: Animals; Diet; Disease Models, Animal; Feeding Behavior; Male; Oxonic Acid; Rats; Time Factors; Tria | 1979 |
The fanconi syndrome in Basenji dogs: a new model for renal transport defects.
Topics: Amino Acids; Animals; Disease Models, Animal; Dog Diseases; Dogs; Fanconi Syndrome; Female; Glomerul | 1978 |
[Relation of uric acid and arteriosclerosis on an experimental model of chickens fed with eggs. Influence of insulin and oral antidiabetics (glibenclamide and tolbutamide)].
Topics: Animals; Arteriosclerosis; Chickens; Cholesterol, Dietary; Disease Models, Animal; Eggs; Glyburide; | 1975 |
Dietary protein level and experimental aortic atherosclerosis.
Topics: Animals; Aortic Diseases; Arteriosclerosis; Body Weight; Cholesterol; Columbidae; Dietary Proteins; | 1977 |
Nephropathy and urinary stones in hyperuricemic rats. The effect of aspirin.
Topics: Animals; Aspirin; Disease Models, Animal; Granuloma; Male; Nephritis; Rats; Uric Acid; Urinary Calcu | 1977 |
Acute uric acid nephropathy.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Humans; Rats; Uric Acid | 1977 |
The gouty kidney.
Topics: Animals; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Gout; Humans; Kidney; Kidney C | 1977 |
[Problem of adjuvant arthritis].
Topics: Alkaline Phosphatase; Animals; Arthritis, Rheumatoid; Body Weight; Disease Models, Animal; Male; Org | 1976 |
A micropuncture study of the early phase of acute urate nephropathy.
Topics: Absorption; Acute Disease; Acute Kidney Injury; Animals; Carbonates; Disease Models, Animal; Glomeru | 1976 |
Platelet aggregation in rats made hyperuricaemic with nucleic adid-rich diets containing oxonate, and inhibitor of uricase [proceedings].
Topics: Animals; Diet; Disease Models, Animal; Female; Fusarium; Gout; Nucleic Acids; Oxonic Acid; Platelet | 1976 |
The influence of the extracellular fluid volume on the tubular reabsorption of uric acid.
Topics: Allantoin; Animals; Disease Models, Animal; Extracellular Space; Inulin; Isotonic Solutions; Kidney | 1975 |
Chronic experimental hyperuricemic nephropathy.
Topics: Animals; Disease Models, Animal; Gout; Kidney; Kidney Calculi; Nephritis, Interstitial; Oxonic Acid; | 1975 |
Acute hyperuricemic nephropathy in rats. An electron microscopic study.
Topics: Animals; Disease Models, Animal; Gout; Kidney; Kidney Calculi; Kidney Diseases; Kidney Tubules; Male | 1975 |
Experimental inflammation induced by naturally occurring microcrystalline calcium salts.
Topics: Animals; Anti-Inflammatory Agents; Calcium; Calcium Phosphates; Carrageenan; Colchicine; Copper; Dis | 1976 |
Uric acid as biochemical marker for retinal and optic nerve damage after occlusion and reperfusion of common carotid and vertebral arteries in rat.
Topics: Animals; Arterial Occlusive Diseases; Biomarkers; Carotid Artery Diseases; Chromatography, High Pres | 1992 |
Neurogenic component of different models of acute inflammation in the rat knee joint.
Topics: Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hindlimb; Inflammation; Joint | 1991 |
Heterotopic liver transplantation corrects the inborn error of hepatic metabolism in a dog model.
Topics: Allantoin; Animals; Biomarkers; Cyclosporins; Disease Models, Animal; Dogs; Liver Transplantation; M | 1991 |
Acute intestinal infarction or obstruction: search for better laboratory tests in an animal model.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Glucosidases; Animals; Aspartate Aminotransferases | 1988 |
Crystal-induced inflammation in the rat subcutaneous air-pouch.
Topics: Animals; Anti-Inflammatory Agents; Calcium Pyrophosphate; Colchicine; Diphosphates; Disease Models, | 1987 |
Ankle joint urate arthritis in rats provides a useful tool for the evaluation of analgesic and anti-arthritic agents.
Topics: Analgesics; Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis; Disease Models, Animal; Drug | 1988 |
Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund's adjuvant.
Topics: Animals; Ankle Joint; Arthritis; Arthritis, Experimental; Disease Models, Animal; Rats; Uric Acid | 1987 |
Plasma and cerebrospinal fluid nucleosides and oxypurines in acute liver failure.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Guanosine; Hepatectomy; Hypox | 1987 |
Requiem for gouty nephropathy.
Topics: Acute Disease; Aged; Animals; Chronic Disease; Disease Models, Animal; Gout; Humans; Kidney; Kidney | 1986 |
A model of renal insufficiency in the chick.
Topics: Animals; Calcium; Chickens; Disease Models, Animal; Kidney Failure, Chronic; Ligation; Magnesium; Ma | 1972 |
Experimental infection with Plasmodium falciparum in Aotus monkeys. I. Parasitologic, hematologic, and serum biochemical determinations.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Cell Count; Blood Glucose; Blood P | 1972 |
Urate deposition disease. How is it regulated and how can it be modified?
Topics: Animals; Blood Proteins; Disease Models, Animal; Gout; Humans; Hydrogen-Ion Concentration; Kidney; K | 1973 |
Changes of metabolism detected after head injury in patients and rats.
Topics: Acetates; Adenosine Triphosphate; Animals; Brain Concussion; Craniocerebral Trauma; Creatine Kinase; | 1973 |
A preliminary report of nephropathy in hyperuricemic rats.
Topics: Animals; Body Weight; Disease Models, Animal; Gout; Kidney; Kidney Calculi; Kidney Diseases; Kidney | 1974 |
Urate excretion and urine flow in a lithium-induced diabetes insipidus rat model.
Topics: Animals; Diabetes Insipidus; Disease Models, Animal; Injections, Intraperitoneal; Lithium; Male; Rat | 1974 |
Fortuitous discovery of urate nephrolithiasis in rats subjected to portacaval anastomosis.
Topics: Animals; Body Weight; Disease Models, Animal; Kidney Calculi; Male; Portacaval Shunt, Surgical; Rats | 1972 |
[Hyperuricemia].
Topics: Animals; Disease Models, Animal; Dogs; Gout; Mice; Uric Acid | 1972 |
Comparative cardiovascular adaptation to exercise in animals and man and its relevance to coronary heart disease.
Topics: Adaptation, Physiological; Animals; Autopsy; Blood Coagulation; Blood Glucose; Blood Pressure; Body | 1972 |
Experimental study on certain methods of decreasing the urinary excretion of uric acid.
Topics: Allopurinol; Animals; Antibody Formation; Antigen-Antibody Complex; Catalysis; Disease Models, Anima | 1970 |