uric acid has been researched along with Diarrhea in 32 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy and safety of febuxostat extended release (XR) and immediate release (IR) in patients with gout and normal or impaired renal function." | 9.30 | Efficacy and Safety of Febuxostat Extended and Immediate Release in Patients With Gout and Renal Impairment: A Phase III Placebo-Controlled Study. ( Becker, MA; Castillo, M; Gunawardhana, L; Hunt, B; Kisfalvi, K; Saag, KG; Whelton, A, 2019) |
| "A dosage of 300 mg/d of allopurinol was not effective in reducing pain or improving activities of daily living in chronic pancreatitis." | 9.08 | Does allopurinol reduce pain of chronic pancreatitis? ( Banks, PA; Ferrante, M; Hughes, M; Noordhoek, EC; Ramagopal, V; Slivka, A, 1997) |
| "This study investigated the correlation among kidney function, intestinal enzyme activities, and microbial activity of adenine and Folium sennae-induced diarrhea model in mice, which provided a basis for clinical treatment of kidney-intestinal correlation." | 8.31 | Correlation Between Kidney Function and Intestinal Biological Characteristics of Adenine and Folium SennaeInduced Diarrhea Model in Mice. ( Li, X; Tan, Z; Wu, Y; Zhu, J, 2023) |
| "To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout." | 8.31 | Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. ( Bajpai, R; Clarson, LE; Forrester, H; Mallen, CD; Muller, S; Padmanabhan, N; Partington, RJ; Roddy, E; Whittle, R, 2023) |
| "To assess the efficacy and safety of febuxostat extended release (XR) and immediate release (IR) in patients with gout and normal or impaired renal function." | 5.30 | Efficacy and Safety of Febuxostat Extended and Immediate Release in Patients With Gout and Renal Impairment: A Phase III Placebo-Controlled Study. ( Becker, MA; Castillo, M; Gunawardhana, L; Hunt, B; Kisfalvi, K; Saag, KG; Whelton, A, 2019) |
| "A dosage of 300 mg/d of allopurinol was not effective in reducing pain or improving activities of daily living in chronic pancreatitis." | 5.08 | Does allopurinol reduce pain of chronic pancreatitis? ( Banks, PA; Ferrante, M; Hughes, M; Noordhoek, EC; Ramagopal, V; Slivka, A, 1997) |
| "This study investigated the correlation among kidney function, intestinal enzyme activities, and microbial activity of adenine and Folium sennae-induced diarrhea model in mice, which provided a basis for clinical treatment of kidney-intestinal correlation." | 4.31 | Correlation Between Kidney Function and Intestinal Biological Characteristics of Adenine and Folium SennaeInduced Diarrhea Model in Mice. ( Li, X; Tan, Z; Wu, Y; Zhu, J, 2023) |
| "To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout." | 4.31 | Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. ( Bajpai, R; Clarson, LE; Forrester, H; Mallen, CD; Muller, S; Padmanabhan, N; Partington, RJ; Roddy, E; Whittle, R, 2023) |
| " Pure and mixed uric acid stones were strongly associated with a gouty diathesis, and vice versa." | 3.72 | Predictive value of kidney stone composition in the detection of metabolic abnormalities. ( Adams-Huet, B; Pak, CY; Pearle, MS; Poindexter, JR, 2003) |
| "Serum uric acid levels were measured in 133 dehydrated patients admitted with diarrhea." | 3.66 | Hyperuricemia in diarrheal dehydration. ( Adler, R; Grushkin, C; Pazdral, P; Robinson, R, 1982) |
| "Long-term flexible dosing with colestilan reduces serum phosphorus and demonstrates an acceptable safety and tolerability profile." | 2.82 | Long-Term Evaluation of Colestilan in Chronic Kidney Disease Stage 5 Dialysis Patients with Hyperphosphataemia. ( Dimkovic, N; Locatelli, F; Spasovski, G; Wanner, C, 2016) |
| "Diarrhea was responsible for an observed decline in kidney weight and serum sodium, potassium and chloride." | 1.51 | Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats. ( Arbid, MS; Koriem, KMM; Saleh, HN, 2019) |
| "We report on five children with nephrolithiasis from the Goldfields region of Western Australia." | 1.32 | Carbohydrate intolerance and kidney stones in children in the Goldfields. ( Baldwin, DN; Jeffries-Stokes, CA; Spencer, JL, 2003) |
| "A 13-year-old boy with ulcerative colitis was admitted to our hospital for the purpose of controlling diarrhea." | 1.31 | [A pediatric case of ammonium acid urate lithiasis with ulcerative colitis]. ( Fukumori, T; Kagawa, S; Kanayama, HO; Kurokawa, Y; Oka, N; Shirane, Y; Takahasi, M; Yamamoto, Y, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (62.50) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Zhu, J | 1 |
| Wu, Y | 1 |
| Tan, Z | 1 |
| Roddy, E | 1 |
| Bajpai, R | 1 |
| Forrester, H | 1 |
| Partington, RJ | 1 |
| Mallen, CD | 1 |
| Clarson, LE | 1 |
| Padmanabhan, N | 1 |
| Whittle, R | 1 |
| Muller, S | 1 |
| Saag, KG | 1 |
| Becker, MA | 1 |
| Whelton, A | 1 |
| Hunt, B | 1 |
| Castillo, M | 1 |
| Kisfalvi, K | 1 |
| Gunawardhana, L | 1 |
| Koriem, KMM | 1 |
| Arbid, MS | 1 |
| Saleh, HN | 1 |
| Ku, E | 1 |
| Thomas, M | 1 |
| Ho, CH | 1 |
| Whipple, NS | 1 |
| Abdul-Rahman, O | 1 |
| Megason, GC | 1 |
| Herrington, BL | 1 |
| Carmody, JB | 1 |
| Charlton, JR | 1 |
| Locatelli, F | 1 |
| Spasovski, G | 1 |
| Dimkovic, N | 1 |
| Wanner, C | 1 |
| Imran, K | 1 |
| Zafar, MN | 1 |
| Ozair, U | 1 |
| Khan, S | 1 |
| Rizvi, SAH | 1 |
| Jabur, WL | 1 |
| Yamamoto, Y | 1 |
| Kurokawa, Y | 1 |
| Oka, N | 1 |
| Takahasi, M | 1 |
| Fukumori, T | 1 |
| Shirane, Y | 1 |
| Kanayama, HO | 1 |
| Kagawa, S | 1 |
| Pak, CY | 1 |
| Poindexter, JR | 1 |
| Adams-Huet, B | 1 |
| Pearle, MS | 1 |
| Baldwin, DN | 1 |
| Spencer, JL | 1 |
| Jeffries-Stokes, CA | 1 |
| Sachdev, HP | 1 |
| Singh, HP | 1 |
| Daral, TS | 1 |
| Mohan, M | 1 |
| Förster, H | 2 |
| Quadbeck, R | 1 |
| Gottstein, U | 1 |
| Akerblom, HK | 1 |
| Koivukangas, T | 1 |
| Puukka, R | 1 |
| Mononen, M | 1 |
| Adler, R | 1 |
| Robinson, R | 1 |
| Pazdral, P | 1 |
| Grushkin, C | 1 |
| Banks, PA | 1 |
| Hughes, M | 1 |
| Ferrante, M | 1 |
| Noordhoek, EC | 1 |
| Ramagopal, V | 1 |
| Slivka, A | 1 |
| Bässler, KH | 1 |
| Matzkies, F | 1 |
| Bröll, H | 1 |
| Sochor, H | 1 |
| Tausch, G | 1 |
| Eberl, R | 1 |
| Bissada, NK | 1 |
| Redman, JF | 1 |
| Mannion, RA | 1 |
| Jahnecke, J | 1 |
| Reisner, GS | 1 |
| Wilansky, DL | 1 |
| Schneiderman, C | 1 |
| Baddeley, M | 1 |
| Hutchison, JC | 1 |
| Holmes, EL | 1 |
| Oettgen, HF | 1 |
| Stephenson, PA | 1 |
| Schwartz, MK | 1 |
| Leeper, RD | 1 |
| Tallai, L | 1 |
| Tan, CC | 1 |
| Clarkson, BD | 1 |
| Golbey, RB | 1 |
| Krakoff, IH | 1 |
| Karnofsky, DA | 1 |
| Murphy, ML | 1 |
| Burchenal, JH | 1 |
| Gifford, RW | 1 |
| Harvengt, C | 1 |
| Lavenne, F | 1 |
| Lavan, JN | 1 |
| Neale, FC | 1 |
| Posen, S | 1 |
| Sparks, RE | 1 |
| Mason, NS | 1 |
| Meier, PM | 1 |
| Litt, MH | 1 |
| Lindan, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3, Randomized, Double Blind, Multicenter, Placebo Controlled Study to Evaluate the Efficacy and Safety of Febuxostat 40 mg XR, 80 mg XR, 40 mg IR and 80 mg IR in Subjects With Gout[NCT02139046] | Phase 3 | 1,790 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| A Phase III, Multi-center, Open Label, Flexible Dose, Long Term Safety Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With Hyperphosphatemia[NCT00772382] | Phase 3 | 116 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| Apple Cider Vinegar for the Prevention of Urinary Lithiasis (APUL)[NCT04073719] | 50 participants (Anticipated) | Interventional | 2019-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"A participant was considered to have a gout flare if the following criteria were met:~Participant-reported acute particular pain typical of a gout attack that was deemed by participant and/or investigator to require treatment and was treated with colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids, Participant experienced at least 3 or more of: 1) Joint swelling, 2) Redness, 3) Tenderness, 4) Pain, Participant experienced at least one or more of: 1) Rapid onset of pain, 2) Decreased range of motion, 3) Joint warmth, 4) Other symptoms similar to a prior gout flare." (NCT02139046)
Timeframe: Baseline to Month 3
| Intervention | percentage of participants (Number) |
|---|---|
| Placebo | 20.7 |
| Febuxostat IR 40 mg | 21.0 |
| Febuxostat XR 40 mg | 22.8 |
| Febuxostat IR 80 mg | 27.2 |
| Febuxostat XR 80 mg | 26.6 |
(NCT02139046)
Timeframe: Month 3
| Intervention | percentage of participants (Number) |
|---|---|
| Placebo | 0.3 |
| Febuxostat IR 40 mg | 15.7 |
| Febuxostat XR 40 mg | 25.9 |
| Febuxostat IR 80 mg | 42.6 |
| Febuxostat XR 80 mg | 50.1 |
(NCT02139046)
Timeframe: Month 3
| Intervention | percentage of participants (Number) |
|---|---|
| Placebo | 0.6 |
| Febuxostat IR 40 mg | 40.3 |
| Febuxostat XR 40 mg | 48.2 |
| Febuxostat IR 80 mg | 57.7 |
| Febuxostat XR 80 mg | 61.1 |
(NCT00772382)
Timeframe: 52 weeks
| Intervention | mg/dL (Mean) |
|---|---|
| MCI-196 | -1.18 |
(NCT00772382)
Timeframe: 52 weeks
| Intervention | participants (Number) | ||
|---|---|---|---|
| At least 1 treatment-emergent AE | At least 1 drug-related treatment-emergent AE | At least 1 treatment-emergent serious AE | |
| MCI-196 | 109 | 50 | 63 |
7 trials available for uric acid and Diarrhea
| Article | Year |
|---|---|
Efficacy and Safety of Febuxostat Extended and Immediate Release in Patients With Gout and Renal Impairment: A Phase III Placebo-Controlled Study.
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Colchicine; Cough; Creatinine; Delay | 2019 |
Long-Term Evaluation of Colestilan in Chronic Kidney Disease Stage 5 Dialysis Patients with Hyperphosphataemia.
Topics: Adult; Aged; Bile Acids and Salts; Cholesterol, LDL; Diarrhea; Female; Glycated Hemoglobin; Hemodial | 2016 |
Does allopurinol reduce pain of chronic pancreatitis?
Topics: Abdominal Pain; Activities of Daily Living; Adult; Allopurinol; Ankle; Blood Cell Count; Chronic Dis | 1997 |
The hypotensive action of ethacrynic acid.
Topics: Abdomen; Adult; Aged; Antihypertensive Agents; Black People; Blood Glucose; Blood Pressure Determina | 1968 |
Experimental observations on flufenamic, mefenamic, and meclofenamic acids. IV. Toleration by normal human subjects.
Topics: Adult; Anti-Inflammatory Agents; Aspirin; Biphenyl Compounds; Blood Coagulation; Blood Urea Nitrogen | 1966 |
Ethacrynic acid alone and in combination with methyldopa in the management of mild hypertension. A report of 23 patients.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diarrhea; Drug Synergism; Ethacrynic Acid; Fe | 1970 |
[Influence of aluminum nicotinate on serum lipids].
Topics: Adult; Alkaline Phosphatase; Aluminum; Arteriosclerosis; Blood Glucose; Cardiovascular Diseases; Cho | 1969 |
25 other studies available for uric acid and Diarrhea
| Article | Year |
|---|---|
Correlation Between Kidney Function and Intestinal Biological Characteristics of Adenine and Folium SennaeInduced Diarrhea Model in Mice.
Topics: Adenine; Animals; Creatinine; Diarrhea; Intestinal Mucosa; Kidney; Mice; Urea; Uric Acid | 2023 |
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.
Topics: Adult; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colchicine; Diarrhea; G | 2023 |
Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats.
Topics: Animals; Antidiarrheals; Creatinine; Diarrhea; Humans; Male; Plant Extracts; Plant Leaves; Psidium; | 2019 |
Index of suspicion. Case 1: fever, diarrhea, jaundice, and confusion in an 18-year-old male. Case 2: severe anemia in a 6-month-old girl. Case 3: red urine in a 4-month-old boy.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Anemia; Anti-Inflammatory Agents; Confusion; Congeni | 2014 |
Metabolic risk factors in pediatric stone formers: a report from an emerging economy.
Topics: Adolescent; Age Factors; Ammonia; Calcium; Child; Child, Preschool; Citrates; Diarrhea; Female; Huma | 2017 |
Acute urate nephropathy precipitated by acute diarrhea.
Topics: Acute Disease; Biomarkers; Creatinine; Diarrhea; Fluid Therapy; Humans; Hyperuricemia; Male; Middle | 2009 |
[A pediatric case of ammonium acid urate lithiasis with ulcerative colitis].
Topics: Adolescent; Chronic Disease; Colitis, Ulcerative; Diarrhea; Humans; Male; Uric Acid; Urinary Calculi | 2002 |
Predictive value of kidney stone composition in the detection of metabolic abnormalities.
Topics: Acidosis, Renal Tubular; Adolescent; Adult; Aged; Ambulatory Care; Apatites; Calcium; Calcium Oxalat | 2003 |
Carbohydrate intolerance and kidney stones in children in the Goldfields.
Topics: Carbohydrates; Child, Preschool; Diarrhea; Failure to Thrive; Female; Humans; Infant; Kidney Calculi | 2003 |
Hyperuricemia in acute dehydrating diarrhea.
Topics: Acute Disease; Child; Child, Preschool; Dehydration; Diarrhea; Fluid Therapy; Humans; Prospective St | 1984 |
Metabolic tolerance to high doses of oral xylitol in human volunteers not previously adapted to xylitol.
Topics: Adult; Calcium; Cholesterol; Diarrhea; Drug Administration Schedule; Female; Humans; Male; Oxalates; | 1982 |
The tolerance of increasing amounts of dietary xylitol in children.
Topics: Abdomen; Administration, Oral; Adolescent; Child; Cholesterol; Diarrhea; Female; Flatulence; Humans; | 1982 |
Hyperuricemia in diarrheal dehydration.
Topics: Blood Urea Nitrogen; Child, Preschool; Dehydration; Diarrhea; Humans; Hypernatremia; Infant; Infant, | 1982 |
[Side effects of sugar substitutes].
Topics: Administration, Oral; Diarrhea; Fatty Liver; Glucose; Glycerol; Humans; Insulin; Insulin Secretion; | 1977 |
Absorption, metabolism, and tolerance of polyol sugar substitutes.
Topics: Absorption; Cataract; Chemical Phenomena; Chemistry; Diarrhea; Glucuronates; Humans; Intestinal Abso | 1978 |
[Effects and side effects of benzbromaron in the initial treatment of hyperuricemia and gout. Results of a field study on 3899 patients].
Topics: Benzbromarone; Benzofurans; Diarrhea; Female; Gout; Humans; Kidney Calculi; Male; Nausea; Uric Acid | 1978 |
[Long-term therapy with benzbromarone in uric arthritis].
Topics: Adult; Aged; Benzbromarone; Benzofurans; Diarrhea; Female; Gout; Humans; Leukopenia; Long-Term Care; | 1975 |
Medical management of urolithiasis.
Topics: Anti-Bacterial Agents; Calcium; Cystinuria; Diarrhea; Female; Humans; Hydrochlorothiazide; Intestina | 1976 |
The negative effects of supervoltage external irradiation in prostatic carcinoma: report of 2 cases.
Topics: Acid Phosphatase; Adenocarcinoma; Aged; Anorexia Nervosa; Barium Sulfate; Biopsy, Needle; Blood Urea | 1974 |
[Side effects of antihypertensive agents].
Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Diarrhea; Diuretics; Fatigue; Ganglionic Blockers; Ga | 1970 |
Uric acid lithiasis in the ileostomy patient.
Topics: Adult; Anuria; Body Water; Diarrhea; Female; Humans; Hydrogen-Ion Concentration; Ileostomy; Male; Mi | 1973 |
Surgical treatment of obesity.
Topics: Blood Sedimentation; Calcium; Cholesterol; Diarrhea; Fatty Liver; Folic Acid; Humans; Ileostomy; Iro | 1973 |
Toxicity of E. coli L-asparaginase in man.
Topics: Adult; Agranulocytosis; Antigen-Antibody Reactions; Asparaginase; Blood Platelet Disorders; Bone Mar | 1970 |
Urinary calculi. Clinical, biochemical and radiological studies in 619 patients.
Topics: Adolescent; Adult; Age Factors; Aged; Australia; Calcium; Child; Cystinuria; Diarrhea; Female; Human | 1971 |
Removal of uremic waste metabolites from the intestinal tract by encapsulated carbon and oxidized starch.
Topics: Adsorption; Aldehydes; Ammonia; Animals; Capsules; Carbon; Cellulose; Creatinine; Diarrhea; Feces; H | 1971 |