uric acid has been researched along with Depression in 31 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation." | 8.02 | Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status. ( Ahn, YM; Lee, H; Rhee, SJ, 2021) |
| "We aimed to investigate the difference in serum uric acid(SUA)levels between subtypes of depression and normal population, and whether SUA can be used to identify bipolar disorder depressive episode and major depressive disorder and predict the length of hospital stay." | 7.96 | Serum uric acid a depression biomarker. ( Deng, W; Huang, X; Li, J; Li, T; Meng, X, 2020) |
| "Few studies have investigated the sex-related associations between serum uric acid and depression." | 7.91 | Associations between serum uric acid and depression among middle-aged and elderly participants in China. ( Ding, G; Li, Y; Yu, D; Zhao, L, 2019) |
| "To clarify the correlation of fatigue during the acute stage of stroke with serum uric acid (UA) and glucose levels, depression, and disability." | 7.80 | Correlation of fatigue during the acute stage of stroke with serum uric acid and glucose levels, depression, and disability. ( Huang, K; Shang, X; Teng, W; Wang, L; Wu, D, 2014) |
| "This study was designed to investigate the correlation between serum uric acid (UA) levels and the clinical characteristics of depression." | 7.78 | Serum uric acid levels and the clinical characteristics of depression. ( Cheng, M; Li, G; Peng, F; Wang, H; Wen, S; Yue, J; Zheng, L; Zhong, Z, 2012) |
| "BACKGROUND Depression is the main problem of psycho-nephrology." | 5.56 | Association Between Serum Uric Acid and Depression in Patients with Chronic Kidney Disease not Requiring Kidney Dialysis: Cross-Sectional and Longitudinal Analyses. ( Chang, W; Gao, B; Han, Y; Hao, J; Li, J; Qi, P; Song, X; Sun, N; Uchida, S; Zhang, M, 2020) |
| "Uric acid is known for its antioxidant capacity; however, whether uric acid is independently associated with depression in the older population remains controversial." | 4.31 | Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey. ( Kim, JO; Lee, S; Oh, JW; Park, GN, 2023) |
| "Despite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation." | 4.02 | Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status. ( Ahn, YM; Lee, H; Rhee, SJ, 2021) |
| "We aimed to investigate the difference in serum uric acid(SUA)levels between subtypes of depression and normal population, and whether SUA can be used to identify bipolar disorder depressive episode and major depressive disorder and predict the length of hospital stay." | 3.96 | Serum uric acid a depression biomarker. ( Deng, W; Huang, X; Li, J; Li, T; Meng, X, 2020) |
| "Few studies have investigated the sex-related associations between serum uric acid and depression." | 3.91 | Associations between serum uric acid and depression among middle-aged and elderly participants in China. ( Ding, G; Li, Y; Yu, D; Zhao, L, 2019) |
| "This study examines the effects of malondialdehyde (MDA) and uric acid on insulin resistance and atherogenicity in subjects with and without mood disorders, the metabolic syndrome (MetS) and tobacco use disorder (TUD)." | 3.81 | Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder. ( Barbosa, DS; Berk, M; Bortolasci, CC; de Castro, MR; de Melo, LG; Dodd, S; Maes, M; Moreira, EG; Vargas Nunes, SO; Vargas, HO, 2015) |
| "To clarify the correlation of fatigue during the acute stage of stroke with serum uric acid (UA) and glucose levels, depression, and disability." | 3.80 | Correlation of fatigue during the acute stage of stroke with serum uric acid and glucose levels, depression, and disability. ( Huang, K; Shang, X; Teng, W; Wang, L; Wu, D, 2014) |
| " In ET patients, cognitive scores were correlated with serum levels of uric acid, education, tremor Rating Scale for Tremor-motor subscale score and depression levels (r = 0." | 3.80 | [Cognitive dysfuctions associated with essential tremor and Parkinson's disease]. ( Chen, J; Chen, Y; Liu, C; Mao, C; Wu, Y; Yao, J, 2014) |
| "This study was designed to investigate the correlation between serum uric acid (UA) levels and the clinical characteristics of depression." | 3.78 | Serum uric acid levels and the clinical characteristics of depression. ( Cheng, M; Li, G; Peng, F; Wang, H; Wen, S; Yue, J; Zheng, L; Zhong, Z, 2012) |
| "Correlations between serum uric acid, cortisol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and psychometric indices of stress--namely, anxiety, hostility, and depression--were investigated in 20 students over a 2 1/2 month academic quarter." | 3.66 | Psychologic correlates of serum indicators of stress in man: a longitudinal study. ( Francis, KT, 1979) |
| " The analyses demonstrated a decrease in the output of uric acid, characteristic of severe depression, and an increase in the excretion of hypoxanthine." | 3.65 | Urinary purine levels in suicide. ( Lis, AW; McLaughlin, DI; McLaughlin, RK, 1975) |
| "Depression is a common psychiatric health issue affecting an estimated 5% of adults worldwide, and it can lead to disability and increased economic burden." | 1.91 | Sex difference in the associations among risk factors with depression in a large Taiwanese population study. ( Chen, SC; Geng, JH; Lee, JI; Tseng, H, 2023) |
| "BACKGROUND Depression is the main problem of psycho-nephrology." | 1.56 | Association Between Serum Uric Acid and Depression in Patients with Chronic Kidney Disease not Requiring Kidney Dialysis: Cross-Sectional and Longitudinal Analyses. ( Chang, W; Gao, B; Han, Y; Hao, J; Li, J; Qi, P; Song, X; Sun, N; Uchida, S; Zhang, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (22.58) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 12 (38.71) | 2.80 |
| Authors | Studies |
|---|---|
| Rhee, SJ | 1 |
| Lee, H | 1 |
| Ahn, YM | 1 |
| Yao, C | 1 |
| Niu, L | 1 |
| Fu, Y | 1 |
| Zhu, X | 1 |
| Yang, J | 1 |
| Zhao, P | 1 |
| Sun, X | 1 |
| Ma, Y | 1 |
| Li, S | 1 |
| Li, J | 4 |
| Jiménez-Fernández, S | 1 |
| Gurpegui, M | 1 |
| Garrote-Rojas, D | 1 |
| Gutiérrez-Rojas, L | 1 |
| Carretero, MD | 1 |
| Correll, CU | 1 |
| Sikka, P | 1 |
| Behl, T | 1 |
| Chandel, P | 1 |
| Sehgal, A | 1 |
| Singh, S | 1 |
| Makeen, HA | 1 |
| Albratty, M | 1 |
| Alhazmi, HA | 1 |
| Meraya, AM | 1 |
| Tseng, H | 1 |
| Lee, JI | 1 |
| Geng, JH | 1 |
| Chen, SC | 1 |
| Kim, JO | 1 |
| Park, GN | 1 |
| Oh, JW | 1 |
| Lee, S | 1 |
| Han, Y | 2 |
| Song, X | 3 |
| Liu, Y | 1 |
| Zhang, W | 1 |
| Tu, Y | 1 |
| Chang, W | 2 |
| Meng, X | 1 |
| Huang, X | 1 |
| Deng, W | 1 |
| Li, T | 2 |
| Kim, WJ | 1 |
| Kim, HR | 1 |
| Song, JS | 1 |
| Choi, ST | 1 |
| Gao, B | 1 |
| Hao, J | 1 |
| Zhang, M | 1 |
| Sun, N | 1 |
| Qi, P | 1 |
| Uchida, S | 1 |
| Winzer, E | 1 |
| Ludvik, B | 1 |
| Grabovac, I | 1 |
| Kruschitz, R | 1 |
| Schindler, K | 1 |
| Prager, G | 1 |
| Klammer, C | 1 |
| Hoppichler, F | 1 |
| Marculescu, R | 1 |
| Wakolbinger, M | 1 |
| Zhao, SS | 1 |
| Qian, Y | 1 |
| Mackie, SL | 1 |
| Wen, C | 1 |
| Mao, Y | 1 |
| Bartoli, F | 2 |
| Clerici, M | 1 |
| Crocamo, C | 2 |
| Carrà, G | 2 |
| Xue, T | 1 |
| Li, H | 2 |
| Wang, MT | 1 |
| Shi, Y | 1 |
| Shi, K | 1 |
| Cheng, Y | 1 |
| Cui, DH | 1 |
| Zhang, Z | 1 |
| Zhang, R | 1 |
| Wang, M | 1 |
| Lin, D | 1 |
| Shao, J | 1 |
| Ma, X | 1 |
| Li, Y | 1 |
| Zhao, L | 1 |
| Yu, D | 1 |
| Ding, G | 1 |
| Wu, D | 1 |
| Wang, L | 1 |
| Teng, W | 1 |
| Huang, K | 1 |
| Shang, X | 1 |
| Chen, J | 2 |
| Yao, J | 1 |
| Wu, Y | 1 |
| Chen, Y | 1 |
| Mao, C | 1 |
| Liu, C | 1 |
| Tao, R | 1 |
| Bortolasci, CC | 1 |
| Vargas, HO | 1 |
| Vargas Nunes, SO | 1 |
| de Melo, LG | 1 |
| de Castro, MR | 1 |
| Moreira, EG | 1 |
| Dodd, S | 1 |
| Barbosa, DS | 1 |
| Berk, M | 1 |
| Maes, M | 1 |
| Liu, T | 1 |
| Zhong, S | 1 |
| Liao, X | 1 |
| He, T | 1 |
| Lai, S | 1 |
| Jia, Y | 1 |
| Wen, S | 1 |
| Cheng, M | 1 |
| Wang, H | 2 |
| Yue, J | 1 |
| Li, G | 1 |
| Zheng, L | 1 |
| Zhong, Z | 1 |
| Peng, F | 1 |
| Johnson, FN | 1 |
| Amdisen, A | 1 |
| Patier, JL | 1 |
| San Millán, J | 1 |
| Serrano, M | 1 |
| Francis, KT | 1 |
| Lis, AW | 1 |
| McLaughlin, RK | 1 |
| McLaughlin, DI | 1 |
| Niklasson, F | 1 |
| Hetta, J | 1 |
| Degrell, I | 1 |
| Stunkard, AJ | 1 |
| Rush, J | 1 |
| Rao, CK | 1 |
| Kasl, SV | 1 |
| Cobb, S | 1 |
| Brooks, GW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analysis of Parameters Indicating the Intensity of Suicidal Behavior in Patients Suffering From Depression and Schizophrenia[NCT05803447] | 120 participants (Actual) | Observational | 2016-09-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for uric acid and Depression
| Article | Year |
|---|---|
Oxidative stress parameters and antioxidants in adults with unipolar or bipolar depression versus healthy controls: Systematic review and meta-analysis.
Topics: Adult; Antioxidants; Biomarkers; Bipolar Disorder; Catalase; Depression; Glutathione Peroxidase; Hum | 2022 |
Scrutinizing the Therapeutic Promise of Purinergic Receptors Targeting Depression.
Topics: Adenosine; Adenosine Triphosphate; Antidepressive Agents; Depression; Humans; Male; Receptors, Purin | 2022 |
A Meta-Analysis of Oxidative Stress Markers in Depression.
Topics: Albumins; Antidepressive Agents; Antioxidants; Aryldialkylphosphatase; Ascorbic Acid; Biomarkers; Ca | 2015 |
Dieting and depression reexamined. A critical review of reports of untoward responses during weight reduction for obesity.
Topics: Affective Symptoms; Age Factors; Ambulatory Care; Child; Depression; Diet, Reducing; Fasting; Female | 1974 |
27 other studies available for uric acid and Depression
| Article | Year |
|---|---|
Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status.
Topics: Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Depression; Female; Humans; Inflamma | 2021 |
Cognition, motor symptoms, and glycolipid metabolism in Parkinson's disease with depressive symptoms.
Topics: Cognition; Depression; Glycolipids; Humans; Mental Status and Dementia Tests; Parkinson Disease; Uri | 2022 |
Sex difference in the associations among risk factors with depression in a large Taiwanese population study.
Topics: Adult; Blood Pressure; Depression; Diabetes Mellitus; Female; Glycated Hemoglobin; Humans; Hypertens | 2023 |
Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey.
Topics: Aged; Depression; Female; Humans; Male; Nutrition Surveys; Republic of Korea; Uric Acid | 2023 |
The effects of depression and age on sleep disturbances in patients with non-dialysis stage 3-5 chronic kidney disease: a single-center study.
Topics: Adult; Age Factors; Aged; Cross-Sectional Studies; Depression; Dietary Proteins; Female; Glomerular | 2020 |
Serum uric acid a depression biomarker.
Topics: Adolescent; Adult; Aged; Biomarkers; Bipolar Disorder; Case-Control Studies; China; Depression; Depr | 2020 |
Low levels of serum urate are associated with a higher prevalence of depression in older adults: a nationwide cross-sectional study in Korea.
Topics: Adult; Aged; Cross-Sectional Studies; Depression; Female; Humans; Male; Middle Aged; Nutrition Surve | 2020 |
Association Between Serum Uric Acid and Depression in Patients with Chronic Kidney Disease not Requiring Kidney Dialysis: Cross-Sectional and Longitudinal Analyses.
Topics: Adult; Aged; Cross-Sectional Studies; Depression; Female; Follow-Up Studies; Humans; Longitudinal St | 2020 |
Course of depressive symptomatology and its association with serum uric acid in one-anastomosis gastric bypass patients.
Topics: Adult; Anastomosis, Surgical; Body Mass Index; Depression; Gastric Bypass; Humans; Male; Middle Aged | 2020 |
Genetically predicted serum urate levels have no causal role on depression or other psychiatric disorders.
Topics: Anxiety; Causality; Depression; Depressive Disorder, Major; Genome-Wide Association Study; Gout; Hum | 2021 |
The antioxidant uric acid and depression: clinical evidence and biological hypotheses.
Topics: Antioxidants; Depression; Depressive Disorder; Humans; Oxidative Stress; Uric Acid | 2018 |
Mindfulness meditation improves metabolic profiles in healthy and depressive participants.
Topics: Adolescent; Adult; Aged; Apolipoproteins B; Apolipoproteins E; Blood Glucose; Depression; Female; Hu | 2018 |
Predictive markers of depression in hypertension.
Topics: Age Factors; Aged; Biomarkers; Blood Glucose; Blood Urea Nitrogen; Body Temperature; Case-Control St | 2018 |
Differences in serum uric acid between 'unipolar' and 'bipolar' depression: Preliminary data.
Topics: Bipolar Disorder; Depression; Depressive Disorder, Major; Humans; Preliminary Data; Uric Acid | 2019 |
Associations between serum uric acid and depression among middle-aged and elderly participants in China.
Topics: Aged; Aged, 80 and over; China; Comorbidity; Depression; Female; Humans; Hyperuricemia; Longitudinal | 2019 |
Correlation of fatigue during the acute stage of stroke with serum uric acid and glucose levels, depression, and disability.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Cross-Sectional Studies; Depression; Disability Evalu | 2014 |
[Cognitive dysfuctions associated with essential tremor and Parkinson's disease].
Topics: Cognition; Cognition Disorders; Depression; Depressive Disorder; Essential Tremor; Humans; Language; | 2014 |
High serum uric acid level in adolescent depressive patients.
Topics: Adolescent; Adult; Anxiety; Biomarkers; Brain; Brain Waves; Case-Control Studies; Depression; Electr | 2015 |
Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder.
Topics: Adolescent; Adult; Aged; Atherosclerosis; Biomarkers; Bipolar Disorder; Blood Glucose; Body Mass Ind | 2015 |
Serum uric acid levels and the clinical characteristics of depression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Depression; Female; Humans; Male; | 2012 |
The first era of lithium in medicine. An historical note.
Topics: Chemistry; Depression; Gout; History, 19th Century; History, 20th Century; Humans; Lithium; Mineral | 1983 |
[Young woman with depression, tremors, generalized dystonia and hypouricemia].
Topics: Adult; Brain; Depression; Dystonia; Female; Hepatolenticular Degeneration; Humans; Magnetic Resonanc | 1994 |
Psychologic correlates of serum indicators of stress in man: a longitudinal study.
Topics: Adolescent; Adult; Alabama; Anxiety; Cholesterol; Depression; Female; Hostility; Humans; Hydrocortis | 1979 |
Urinary purine levels in suicide.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Depression; Ethanol; Female; Glycosur | 1975 |
Hypoxanthine, xanthine, urate and creatinine concentration gradients in cerebrospinal fluid.
Topics: Biological Transport, Active; Cisterna Magna; Creatinine; Dementia; Depression; Humans; Hypoxanthine | 1988 |
Combined therapy of E.C.T. and amitriptyline and L-tryptophan in the treatment of severe depression.
Topics: Amitriptyline; Deficiency Diseases; Depression; Electroconvulsive Therapy; Humans; Liver Function Te | 1972 |
Changes in serum uric acid and cholesterol levels in men undergoing job loss.
Topics: Adult; Anxiety; Cholesterol; Depression; Emotions; Humans; Interview, Psychological; Male; Middle Ag | 1968 |