Page last updated: 2024-10-20

uric acid and Dehydration

uric acid has been researched along with Dehydration in 39 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Dehydration: The condition that results from excessive loss of water from a living organism.

Research Excerpts

ExcerptRelevanceReference
"Clinical assessment of dehydration in children with acute gastroenteritis (AGE) is crucial for treatment."6.84Uric acid and dehydration in children with gastroenteritis. ( Hasegawa, Y; Kuge, R; Morikawa, Y, 2017)
" Accelerated generation of uric acid and impaired excretion in the kidney are promoted by several dietary factors, such as foods with higher content of sugars (fructose and xylitol), fat and purine bases, and by alcohol consumption, starvation and dehydration."4.84[How do we set the standard value of serum uric acid levels?]. ( Hamada, T; Hisatome, I; Igawa, O; Shigemasa, C, 2008)
" Some studies have reported substantial weight loss, signs of dehydration, raised serum concentrations of uric acid and cholesterol, etc."3.70[Effects of Ramadan fasting on the health of Muslims]. ( Morimoto, K; Toda, M, 2000)
"Serum uric acid levels were measured in 133 dehydrated patients admitted with diarrhea."3.66Hyperuricemia in diarrheal dehydration. ( Adler, R; Grushkin, C; Pazdral, P; Robinson, R, 1982)
"Clinical assessment of dehydration in children with acute gastroenteritis (AGE) is crucial for treatment."2.84Uric acid and dehydration in children with gastroenteritis. ( Hasegawa, Y; Kuge, R; Morikawa, Y, 2017)
"In the pathway, the solid-state dehydration phase transition occurs inside the crystal prior to its competitive transformation approach mediated by solvent, forming an unconventional core-shell structure."1.91Unusual shape-preserved pathway of a core-shell phase transition triggered by orientational disorder. ( Gong, J; Li, M; Tang, W, 2023)
"Recurrent dehydration, such as commonly occurs with manual labor in tropical environments, has been recently shown to result in chronic kidney injury, likely through the effects of hyperosmolarity to activate both vasopressin and aldose reductase-fructokinase pathways."1.43Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury. ( Arellano-Buendía, AS; Bankir, L; Cristóbal, M; García-Arroyo, FE; Johnson, RJ; Lanaspa, MA; Madero, M; Osorio, H; Roncal-Jiménez, C; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2016)
"Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that might subsequently induce renal injury via metabolism by fructokinase."1.40Fructokinase activity mediates dehydration-induced renal injury. ( Aragón, A; Cicerchi, C; Correa-Rotter, R; Ejaz, AA; Glaser, J; González, MA; Inaba, S; Ishimoto, T; Johnson, RJ; Lanaspa, MA; Le, M; Miyazaki, M; Nakagawa, T; Rivard, CJ; Roncal Jimenez, CA; Sánchez-Lozada, LG; Wesseling, C, 2014)
"Dehydration was defined as uric acid >/= 7 mg dL(-1) according to the standard value."1.34Serum markers of chronic dehydration are associated with saliva spinability. ( Hanada, N; Hirotomi, T; Kondo, T; Miyazaki, H; Takano, N; Yoshihara, A, 2007)
"This study confirms that chronic dehydration represents a real lithogenic risk factor, mainly for uric acid stones, and adequate fluid intake is recommended during hot occupations."1.29Hot occupation and nephrolithiasis. ( Amato, F; Borghi, L; Cigala, F; Meschi, T; Novarini, A; Romanelli, A, 1993)
"Fourteen cases of acute renal failure secondary to administration of radiographic contrast media were observed, eight within a 15-month period."1.26Acute renal failure. Association with administration of radiographic contrast material. ( del Greco, F; Krumlovsky, FA; Pomaranc, MM; Roxe, D; Santhanam, S; Simon, N, 1978)
"Twenty-one patients developed acute renal failure in association with nontraumatic rhabdomyolysis and myoglobinuria."1.26Acute renal failure due to nontraumatic rhabdomyolysis. ( Friedler, RM; Koffler, A; Massry, SG, 1976)
"4."1.25Acute renal failure in multiple myeloma. ( Cooke, CR; Defronzo, RA; Humphrey, RL; Wright, JR, 1975)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199019 (48.72)18.7374
1990's2 (5.13)18.2507
2000's6 (15.38)29.6817
2010's9 (23.08)24.3611
2020's3 (7.69)2.80

Authors

AuthorsStudies
Kawaguchi, Y1
Hanafusa, N1
Sakurai, S1
Miyaji, M1
Toda, N1
Iwadoh, K1
Tsuchiya, K1
Li, M1
Tang, W1
Gong, J1
Ito, H1
Kuge, R1
Morikawa, Y1
Hasegawa, Y1
Zafar, MN1
Ayub, S1
Tanwri, H1
Naqvi, SAA1
Rizvi, SAH1
Roncal Jimenez, CA1
Ishimoto, T1
Lanaspa, MA2
Rivard, CJ1
Nakagawa, T1
Ejaz, AA1
Cicerchi, C1
Inaba, S1
Le, M1
Miyazaki, M1
Glaser, J1
Correa-Rotter, R1
González, MA1
Aragón, A1
Wesseling, C2
Sánchez-Lozada, LG2
Johnson, RJ3
Hou, SK1
Chiu, YH1
Tsai, YF1
Tai, LC1
Hou, PC1
How, CK1
Yang, CC1
Kao, WF1
Roncal-Jimenez, CA1
García-Trabanino, R1
García-Arroyo, FE1
Cristóbal, M1
Arellano-Buendía, AS1
Osorio, H1
Tapia, E1
Soto, V1
Madero, M1
Roncal-Jiménez, C1
Bankir, L1
Lotan, Y1
Antonelli, J1
Jiménez, IB1
Gharbi, H1
Herring, R1
Beaver, A1
Dennis, A1
Von Merveldt, D1
Carter, S1
Cohen, A1
Poindexter, J1
Moe, OW1
Pearle, MS1
Okubo, K1
Okubo, H1
Kamijo, Y1
Higuchi, M1
Trabelsi, K1
Stannard, SR1
Maughan, RJ1
Jammoussi, K1
Zeghal, K1
Hakim, A1
Büyükgebiz, B1
Arslan, N1
Oztürk, Y1
Soylu, A1
Kavukçu, S1
Todd, CD1
Tipton, PA1
Blevins, DG1
Piedras, P1
Pineda, M1
Polacco, JC1
Yoshihara, A1
Hirotomi, T1
Takano, N1
Kondo, T1
Hanada, N1
Miyazaki, H1
Choi, HD1
Kang, HE1
Chung, HJ1
Bae, SK1
Shin, KN1
Lee, MG1
Hamada, T1
Igawa, O1
Shigemasa, C1
Hisatome, I1
Sachdev, HP1
Singh, HP1
Daral, TS1
Mohan, M1
Adler, R1
Robinson, R1
Pazdral, P1
Grushkin, C1
Borghi, L1
Meschi, T1
Amato, F1
Novarini, A1
Romanelli, A1
Cigala, F1
Palla, G1
Ughi, C1
Cesaretti, G1
Ventura, A1
Maggiore, G1
Toda, M1
Morimoto, K1
Broadus, AE1
Thier, SO1
Martines-Maldonado, M1
Stavroulaki-Tsapara, A1
Tsaparas, N1
Suki, WN1
Eknoyan, G1
Krumlovsky, FA1
Simon, N1
Santhanam, S1
del Greco, F1
Roxe, D1
Pomaranc, MM1
Koffler, A1
Friedler, RM1
Massry, SG1
Defronzo, RA1
Humphrey, RL1
Wright, JR1
Cooke, CR1
Lenert, P1
Drazen, F1
Tepavcević, P1
Pejin, D1
Curić, S1
Ilić, V1
Uzurov, V1
Popowić, S1
Zupunski, A1
Djisalov, M1
Burmeister, H1
Ohlmeier, H1
Baethke, R1
Feldman, HA1
Goldfarb, S1
McCurdy, DK1
Mathew, T1
Curtis, J1
Horrigan, F1
Ahearn, D1
Varney, R1
Sandler, SG1
Taitz, LS1
Byers, HD1
Sutton, J1
Coleman, MJ1
Millar, AP1
Lazarus, L1
Russo, P1
Gigax, JH1
Leach, JR1
Leu, ML1
Strickland, GT1
Gutman, RA1
Johnson, RH1
Corbett, JL1
Wilkinson, RH1
Horne, FR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Variation in Urine Electrolytes, pH and Specific Gravity Throughout the Day and the Effect of Increased Fluid Intake on Intra-Day Urine Composition[NCT03645785]23 participants (Actual)Interventional2018-08-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Calcium / Creatinine

Ca/Cr at 4 voids throughout the day. Pre = baseline fluid intake; Post = increased fluid and citrate supplementation (NCT03645785)
Timeframe: Day 1 (first void, 9-10 am, 1-2 pm and 5 pm) and Day 4 (first void, 9-10 am, 1-2 pm and 5 pm)

InterventionRatio (Mean)
5pm Void Post0.162234
5p.m. Pre0.161287
1-2 pm Post0.137398
1-2pm Void Pre0.140431
9-10AM Post0.126269
9-10AM Pre0.111446
First Void Pre0.160932
First Void Post0.142987

Citrate/Creatinine Ratio

Citrate/Cr at 4 voids throughout the day. Pre = baseline fluid intake; Post = increased fluid and citrate supplementation (NCT03645785)
Timeframe: Day 1 (first void, 9-10 am, 1-2 pm and 5 pm) and Day 4 (first void, 9-10 am, 1-2 pm and 5 pm)

Interventionratio (Mean)
5pm Void Post0.658644
5p.m. Pre0.584115
1-2 pm Post0.562886
1-2pm Void Pre0.540394
9-10AM Post0.490685
9-10AM Pre0.441938
First Void Pre0.423415
First Void Post0.404892

pH

pH at 4 voids throughout the day. Pre = baseline fluid intake; Post (NCT03645785)
Timeframe: Day 1 (first void, 9-10 am, 1-2 pm and 5 pm) and Day 4 (first void, 9-10 am, 1-2 pm and 5 pm)

InterventionpH (Mean)
5pm Void Post6.52770
5p.m. Pre6.32645
1-2 pm Post6.34060
1-2pm Void Pre6.37845
9-10AM Post6.43430
9-10AM Pre6.24125
First Void Pre6.08345
First Void Post6.01865

Specific Gravity (SG)

SG at 4 voids throughout the day. Pre = baseline fluid intake; Post (NCT03645785)
Timeframe: Day 1 (first void, 9-10 am, 1-2 pm and 5 pm) and Day 4 (first void, 9-10 am, 1-2 pm and 5 pm)

Interventiong/mL (Mean)
5pm Void Post1.01725
5p.m. Pre1.01525
1-2 pm Post1.01725
1-2pm Void Pre1.01850
9-10AM Post1.01950
9-10AM Pre1.02051
First Void Pre1.02000
First Void Post1.01825

Total Fluid Intake

(NCT03645785)
Timeframe: Over 4 day study period

InterventionmL (Mean)
Day 12416.854
Day 22625.093
Day 33116.562
Day 43396.781

Reviews

3 reviews available for uric acid and Dehydration

ArticleYear
Mesoamerican Nephropathy or Global Warming Nephropathy?
    Blood purification, 2016, Volume: 41, Issue:1-3

    Topics: Adult; Agricultural Workers' Diseases; Aldehyde Reductase; Central America; Creatinine; Dehydration;

2016
Update on ureide degradation in legumes.
    Journal of experimental botany, 2006, Volume: 57, Issue:1

    Topics: Allantoin; Dehydration; Fabaceae; Manganese; Nitrogen; Nitrogen Fixation; Urea; Uric Acid

2006
[How do we set the standard value of serum uric acid levels?].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:4

    Topics: Alcoholic Beverages; Biomarkers; Catalase; Colorimetry; Dehydration; Diet; Humans; Hyperuricemia; Pe

2008

Trials

2 trials available for uric acid and Dehydration

ArticleYear
Uric acid and dehydration in children with gastroenteritis.
    Pediatrics international : official journal of the Japan Pediatric Society, 2017, Volume: 59, Issue:11

    Topics: Biomarkers; Body Weight; Child, Preschool; Dehydration; Female; Fluid Therapy; Gastroenteritis; Huma

2017
The kidney stone and increased water intake trial in steel workers: results from a pilot study.
    Urolithiasis, 2017, Volume: 45, Issue:2

    Topics: Adult; Aged; Calcium; Cross-Sectional Studies; Dehydration; Drinking; Female; Humans; Kidney Calculi

2017

Other Studies

34 other studies available for uric acid and Dehydration

ArticleYear
The uric acid-urea distribution volume ratio is a potential marker of hydration status in patients on hemodialysis.
    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2023, Volume: 26, Issue:4

    Topics: Body Water; Dehydration; Electric Impedance; Humans; Renal Dialysis; Uric Acid; Water; Water Intoxic

2023
Unusual shape-preserved pathway of a core-shell phase transition triggered by orientational disorder.
    IUCrJ, 2023, 01-01, Volume: 10, Issue:Pt 1

    Topics: Crystallization; Dehydration; Humans; Phase Transition; Solvents; Uric Acid

2023
Serum uric acid levels: A surrogate marker of oxidative stress or dehydration?
    European journal of internal medicine, 2021, Volume: 86

    Topics: Acute Coronary Syndrome; Biomarkers; Dehydration; Hospitals; Humans; Oxidative Stress; Uric Acid

2021
Composition of urinary calculi in infants: a report from an endemic country.
    Urolithiasis, 2018, Volume: 46, Issue:5

    Topics: Calcium Oxalate; Dehydration; Diarrhea, Infantile; Endemic Diseases; Female; Humans; Infant; Infant

2018
Fructokinase activity mediates dehydration-induced renal injury.
    Kidney international, 2014, Volume: 86, Issue:2

    Topics: Aldehyde Reductase; Animals; Blood Pressure; Dehydration; Disease Models, Animal; Fructokinases; Kid

2014
Clinical Impact of Speed Variability to Identify Ultramarathon Runners at Risk for Acute Kidney Injury.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Acute Kidney Injury; Adult; Athletes; Biomechanical Phenomena; Body Mass Index; Dehydration; Early D

2015
Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2016, 07-01, Volume: 311, Issue:1

    Topics: Animals; Blood Pressure; Carbonated Beverages; Dehydration; Fluid Therapy; Fructose; Glycopeptides;

2016
Pink urine syndrome.
    Internal medicine (Tokyo, Japan), 2011, Volume: 50, Issue:18

    Topics: Acidosis; Adult; Color; Dehydration; Humans; Hydrogen-Ion Concentration; Male; Syndrome; Uric Acid;

2011
Effect of resistance training during Ramadan on body composition and markers of renal function, metabolism, inflammation, and immunity in recreational bodybuilders.
    International journal of sport nutrition and exercise metabolism, 2012, Volume: 22, Issue:4

    Topics: Adult; Biomarkers; Body Composition; Body Mass Index; Carbon Dioxide; Cholesterol, LDL; Creatinine;

2012
Complication of short bowel syndrome: an infant with short bowel syndrome developing ammonium acid urate urolithiasis.
    Pediatrics international : official journal of the Japan Pediatric Society, 2003, Volume: 45, Issue:2

    Topics: Dehydration; Humans; Infant; Intestinal Obstruction; Kidney Calculi; Male; Short Bowel Syndrome; Uri

2003
Serum markers of chronic dehydration are associated with saliva spinability.
    Journal of oral rehabilitation, 2007, Volume: 34, Issue:10

    Topics: Aged; Biomarkers; Blood Urea Nitrogen; Chronic Disease; Creatinine; Dehydration; Elasticity; Female;

2007
Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats.
    Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:8

    Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Bronchodilator Agents; Dehydration;

2007
Hyperuricemia in acute dehydrating diarrhea.
    Indian pediatrics, 1984, Volume: 21, Issue:11

    Topics: Acute Disease; Child; Child, Preschool; Dehydration; Diarrhea; Fluid Therapy; Humans; Prospective St

1984
Hyperuricemia in diarrheal dehydration.
    American journal of diseases of children (1960), 1982, Volume: 136, Issue:3

    Topics: Blood Urea Nitrogen; Child, Preschool; Dehydration; Diarrhea; Humans; Hypernatremia; Infant; Infant,

1982
Hot occupation and nephrolithiasis.
    The Journal of urology, 1993, Volume: 150, Issue:6

    Topics: Adult; Dehydration; Hot Temperature; Humans; Incidence; Italy; Kidney Calculi; Male; Occupational Di

1993
"Automatic" diagnosis of viral enteritis.
    The Journal of pediatrics, 1997, Volume: 130, Issue:6

    Topics: Child, Preschool; Dehydration; Enteritis; Humans; Retrospective Studies; Salmonella; Uric Acid

1997
[Effects of Ramadan fasting on the health of Muslims].
    Nihon eiseigaku zasshi. Japanese journal of hygiene, 2000, Volume: 54, Issue:4

    Topics: Cholesterol; Dehydration; Fasting; Humans; Hypertension; Islam; Life Style; Uric Acid; Weight Loss

2000
Metabolic basis of renal-stone disease.
    The New England journal of medicine, 1979, Apr-12, Volume: 300, Issue:15

    Topics: Animals; Calcium; Calcium Oxalate; Calcium Phosphates; Cyclic AMP; Cystine; Cystinuria; Dehydration;

1979
Renal effects of lithium administration in rats: alterations in water and electrolyte metabolism and the response to vasopressin and cyclic-adenosine monophosphate during prolonged administration.
    The Journal of laboratory and clinical medicine, 1975, Volume: 86, Issue:3

    Topics: Animals; Body Weight; Bucladesine; Dehydration; Female; Kidney; Kidney Concentrating Ability; Kidney

1975
Acute renal failure. Association with administration of radiographic contrast material.
    JAMA, 1978, Jan-09, Volume: 239, Issue:2

    Topics: Acute Kidney Injury; Administration, Oral; Adult; Age Factors; Aged; Blood Urea Nitrogen; Contrast M

1978
Acute renal failure due to nontraumatic rhabdomyolysis.
    Annals of internal medicine, 1976, Volume: 85, Issue:1

    Topics: Acidosis; Acute Kidney Injury; Adult; Alcoholic Intoxication; Blood Urea Nitrogen; Calcium; Creatini

1976
Acute renal failure in multiple myeloma.
    Medicine, 1975, Volume: 54, Issue:3

    Topics: Acute Kidney Injury; Adult; Aged; Anti-Bacterial Agents; Bence Jones Protein; Blood Proteins; Calciu

1975
Influence of Bence-Jones proteins, hyperviscosity, hypercalcemia, hyperuricemia and dehydration on development of renal changes in plasma cell dyscrasias.
    Przeglad lekarski, 1985, Volume: 42, Issue:4

    Topics: Acute Kidney Injury; Bence Jones Protein; Blood Viscosity; Dehydration; Female; Humans; Hypercalcemi

1985
Cholecystography and renal failure.
    Lancet (London, England), 1971, Jul-17, Volume: 2, Issue:7716

    Topics: Acute Kidney Injury; Administration, Oral; Animals; Cholecystography; Contrast Media; Crystallizatio

1971
[Side effects and complication possibilities following high-dosage furosemide treatment].
    Medizinische Klinik, 1972, Oct-27, Volume: 67, Issue:43

    Topics: Adult; Aged; Alkalosis; Blood Coagulation Disorders; Blood Glucose; Dehydration; Drug Eruptions; Ear

1972
Recurrent radiographic dye-induced acute renal failure.
    JAMA, 1974, Jul-01, Volume: 229, Issue:1

    Topics: Acute Kidney Injury; Adult; Dehydration; Diabetes Complications; Diatrizoate; Hemodynamics; Humans;

1974
Treatment of renal calculi.
    Drugs, 1974, Volume: 8, Issue:1

    Topics: Alkalies; Allopurinol; Ammonia; Calcium; Cystine; Dehydration; Humans; Kidney Calculi; Magnesium; Ph

1974
Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma.
    JAMA, 1972, Jun-19, Volume: 220, Issue:12

    Topics: Adult; Chlorthalidone; Dehydration; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans;

1972
High calorie-osmolar feeding and hypertonic dehydration.
    Archives of disease in childhood, 1972, Volume: 47, Issue:252

    Topics: Animals; Creatinine; Dehydration; Female; Food Handling; Humans; Infant; Infant Nutritional Physiolo

1972
The medical problems of mass participation in athletic competition. The "City-to-Surf" race.
    The Medical journal of Australia, 1972, Jul-15, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Aspartate Aminotransferases; Blood Glucose; Body Temperature; Creatinine; Dehydra

1972
Uric acid calculi associated with ileostomy for ulcerative colitis.
    The Journal of urology, 1971, Volume: 105, Issue:6

    Topics: Acidosis; Adolescent; Adult; Alkalies; Allopurinol; Child; Colectomy; Colitis, Ulcerative; Dehydrati

1971
Renal function in Wilson's disease: response to penicillamine therapy.
    The American journal of the medical sciences, 1970, Volume: 260, Issue:6

    Topics: Adolescent; Adult; Aminohippuric Acids; Ammonium Chloride; Calcium; Dehydration; Female; Follow-Up S

1970
Desert journeys by Bedouin: sweating and concentration of urine during travel by camel and on foot.
    Nature, 1968, Aug-31, Volume: 219, Issue:5157

    Topics: Animals; Arabia; Camelus; Chlorides; Creatinine; Dehydration; Desert Climate; Humans; Hydrogen-Ion C

1968
Nitrogen excretion in crustacea. I. The herbivorous land crab Cardiosoma guanhumi Latreille.
    Comparative biochemistry and physiology, 1968, Volume: 26, Issue:2

    Topics: Ammonia; Animals; Antifungal Agents; Crustacea; Dehydration; Diet; Female; Gills; Metabolism; Nitrog

1968