uric acid has been researched along with Cystic Fibrosis in 24 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using mass spectrometry, oxidation products of glutathione and uric acid were measured in matched samples of bronchoalveolar lavage (BAL), serum and urine from 36 infants and children with CF, and related to markers of neutrophilic inflammation and infection in BAL." | 7.85 | Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. ( Dickerhof, N; Fantino, E; Kettle, AJ; Khalilova, I; Sly, PD; Turner, R, 2017) |
| "Using mass spectrometry, oxidation products of glutathione and uric acid were measured in matched samples of bronchoalveolar lavage (BAL), serum and urine from 36 infants and children with CF, and related to markers of neutrophilic inflammation and infection in BAL." | 3.85 | Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. ( Dickerhof, N; Fantino, E; Kettle, AJ; Khalilova, I; Sly, PD; Turner, R, 2017) |
| "Uric acid metabolism was evaluated in 16 Israeli cystic fibrosis patients, all of whom were taking pancreatic enzyme supplements." | 3.66 | Hyperuricosuria in cystic fibrosis patients treated with pancreatic enzyme supplements. A study of 16 patients in Israel. ( Ben-Zaray, S; Blau, H; Goldfarb, D; Katznelson, D; Sack, J, 1980) |
| " Although the additional daily urate intake through the ingestion of pancreatic enzyme preparations was less than 70 mg in 16 of 18 cystic fibrosis patients, uric acid excretion was astoundingly high." | 3.66 | Studies on the cause of hyperuricosuria in cystic fibrosis patients. ( Niessen, KH; Wolf, A, 1982) |
| "The relationship between the dosage of pancreatic extract and the excretion of uric acid was investigated in 29 patients with cystic fibrosis and exocrine pancreatic insufficiency." | 3.65 | Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. ( Kennedy, J; Linshaw, MA; Nouisa-Arvanitakis, S; Stapleton, FB, 1977) |
| "Dysuria, uric acid crystalluria and hyperuricosuria developed in a child with cystic fibrosis and normal serum uric acid." | 3.65 | Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis. ( Kennedy, J; Linshaw, MA; Nousia-Arvanitakis, S; Stapleton, FB, 1976) |
| " These data suggest that large doses of EC enzymes reduce steatorrhea and are safe in patients who have malabsorbtion with small doses." | 2.67 | Effectiveness and safety of small vs. large doses of enteric coated pancreatic enzymes in reducing steatorrhea in children with cystic fibrosis: a prospective randomized study. ( Brady, MS; Eigen, H; Rickard, K; Yu, PL, 1991) |
| "Urinary tract infections (UTIs) were detected in 65." | 1.39 | Urinary stone disease in the first year of life: is it dangerous? ( Alpay, H; Bıyıklı, N; Gokce, I; Özen, A, 2013) |
| "Gout has not been described previously as a complication in cystic fibrosis (CF)." | 1.37 | Gout and hyperuricaemia in adults with cystic fibrosis. ( Brennan, A; Bright-Thomas, R; Helm, J; Horsley, A; Jones, A; Webb, K, 2011) |
| "The uric acid excretion was lower than in the nocturnal period before the test." | 1.28 | Uric acid serum concentrations in CF-children after pancreatic enzyme supplementation. ( Ballke, EH; Paul, W; Wiersbitzky, S; Wolf, E, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (50.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dickerhof, N | 1 |
| Turner, R | 1 |
| Khalilova, I | 1 |
| Fantino, E | 1 |
| Sly, PD | 1 |
| Kettle, AJ | 1 |
| Livnat, G | 1 |
| Bentur, L | 1 |
| Kuzmisnsky, E | 1 |
| Nagler, RM | 1 |
| Horsley, A | 1 |
| Helm, J | 1 |
| Brennan, A | 1 |
| Bright-Thomas, R | 1 |
| Webb, K | 1 |
| Jones, A | 1 |
| Alpay, H | 1 |
| Gokce, I | 1 |
| Özen, A | 1 |
| Bıyıklı, N | 1 |
| Gibney, EM | 1 |
| Goldfarb, DS | 1 |
| Terribile, M | 1 |
| Capuano, M | 1 |
| Cangiano, G | 1 |
| Carnovale, V | 1 |
| Ferrara, P | 1 |
| Petrarulo, M | 1 |
| Marangella, M | 1 |
| Mandel, ID | 1 |
| Kutscher, A | 1 |
| Denning, CR | 1 |
| Thompson, RH | 1 |
| Zegarelli, EV | 1 |
| Niessen, KH | 2 |
| Sack, J | 1 |
| Blau, H | 1 |
| Goldfarb, D | 1 |
| Ben-Zaray, S | 1 |
| Katznelson, D | 1 |
| Wolf, A | 1 |
| Böhles, H | 1 |
| Michalk, D | 2 |
| Langley, SC | 1 |
| Brown, RK | 2 |
| Kelly, FJ | 2 |
| Wyatt, H | 1 |
| Price, JF | 1 |
| Hoppe, B | 1 |
| Hesse, A | 1 |
| Brömme, S | 1 |
| Rietschel, E | 1 |
| Lands, LC | 1 |
| Grey, VL | 1 |
| Grenier, C | 1 |
| Stanghelle, JK | 1 |
| Koss, JO | 1 |
| Bjørtuft, O | 1 |
| Geiran, O | 1 |
| Davidson, GP | 1 |
| Hassel, FM | 1 |
| Crozier, D | 1 |
| Corey, M | 1 |
| Forstner, GG | 1 |
| Nouisa-Arvanitakis, S | 1 |
| Stapleton, FB | 2 |
| Linshaw, MA | 2 |
| Kennedy, J | 2 |
| Finberg, L | 1 |
| Nousia-Arvanitakis, S | 1 |
| Brady, MS | 1 |
| Rickard, K | 1 |
| Yu, PL | 1 |
| Eigen, H | 1 |
| Wiersbitzky, S | 1 |
| Ballke, EH | 1 |
| Wolf, E | 1 |
| Paul, W | 1 |
| Knoppert, DC | 1 |
| Spino, M | 1 |
| Beck, R | 1 |
| Thiessen, JJ | 1 |
| MacLeod, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pancreatic Enzyme Replacement Therapy (PERT) for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer[NCT02985801] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-12-31 | Terminated (stopped due to Study was terminated due to difficulty in recruiting subjects.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for uric acid and Cystic Fibrosis
| Article | Year |
|---|---|
The association of nephrolithiasis with cystic fibrosis.
Topics: Adolescent; Adult; Animals; Calcium; Calcium Oxalate; Child; Chloride Channels; Citrates; Colon; Cry | 2003 |
[Diseases of the exocrine pancreas in infants and children. A review. 1. Organic pancreatic diseases].
Topics: Amino Acid Metabolism, Inborn Errors; Amylases; Child, Preschool; Cholecystokinin; Cystic Fibrosis; | 1980 |
3 trials available for uric acid and Cystic Fibrosis
| Article | Year |
|---|---|
Urinary excretion substances in patients with cystic fibrosis: risk of urolithiasis?
Topics: Adolescent; Adult; Calcium Oxalate; Calcium Phosphates; Child; Child, Preschool; Cystic Fibrosis; Fe | 1998 |
Effectiveness and safety of small vs. large doses of enteric coated pancreatic enzymes in reducing steatorrhea in children with cystic fibrosis: a prospective randomized study.
Topics: Celiac Disease; Child; Cystic Fibrosis; Dietary Fats; Dietary Proteins; Dose-Response Relationship, | 1991 |
Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease.
Topics: Adolescent; Adult; Biotransformation; Chromatography, High Pressure Liquid; Clinical Trials as Topic | 1988 |
19 other studies available for uric acid and Cystic Fibrosis
| Article | Year |
|---|---|
Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease.
Topics: Biomarkers; Bronchoalveolar Lavage Fluid; Child, Preschool; Cystic Fibrosis; Early Diagnosis; Female | 2017 |
Salivary profile and oxidative stress in children and adolescents with cystic fibrosis.
Topics: Adolescent; Antioxidants; Bronchiectasis; Child; Cystic Fibrosis; Female; Forced Expiratory Volume; | 2010 |
Gout and hyperuricaemia in adults with cystic fibrosis.
Topics: Adult; Cystic Fibrosis; Female; Gout; Humans; Hyperuricemia; Male; Middle Aged; Prevalence; Uric Aci | 2011 |
Urinary stone disease in the first year of life: is it dangerous?
Topics: Cholelithiasis; Citrates; Cystic Fibrosis; Cystinuria; Epilepsy; Female; Genetic Predisposition to D | 2013 |
Factors increasing the risk for stone formation in adult patients with cystic fibrosis.
Topics: Adult; Calcium Oxalate; Creatinine; Cystic Fibrosis; Female; Heterozygote; Humans; Hydrogen-Ion Conc | 2006 |
Salivary studies in cystic fibrosis.
Topics: Adolescent; Ammonia; Amylases; Calcium; Carbohydrates; Child; Chlorides; Cystic Fibrosis; Electropho | 1967 |
Hyperuricosuria in cystic fibrosis patients treated with pancreatic enzyme supplements. A study of 16 patients in Israel.
Topics: Child; Cystic Fibrosis; Dose-Response Relationship, Drug; Humans; Pancreatic Extracts; Pancreatin; U | 1980 |
Studies on the cause of hyperuricosuria in cystic fibrosis patients.
Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Humans; Pancreatin; Purines; Uric Acid | 1982 |
Is there a risk for kidney stone formation in cystic fibrosis?
Topics: Adolescent; Calcium; Child; Cystic Fibrosis; Female; Humans; Kidney Calculi; Magnesium; Male; Pilot | 1982 |
Reduced free-radical-trapping capacity and altered plasma antioxidant status in cystic fibrosis.
Topics: Adolescent; Antioxidants; Ascorbic Acid; Child; Child, Preschool; Cystic Fibrosis; Free Radicals; Hu | 1993 |
Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress.
Topics: Adolescent; Adult; Antioxidants; Ascorbic Acid; Biomarkers; Child; Child, Preschool; Cystic Fibrosis | 1996 |
Total plasma antioxidant capacity in cystic fibrosis.
Topics: Acute Disease; Adolescent; Adult; Antioxidants; Child; Chromans; Cystic Fibrosis; Female; Glutathion | 2000 |
Marathon with cystic fibrosis and bilateral lung transplant.
Topics: Adult; Creatine Kinase; Cystic Fibrosis; Forced Expiratory Volume; Humans; Hydrocortisone; Lung Tran | 2000 |
Hyperuricemia in cystic fibrosis.
Topics: Cystic Fibrosis; Humans; Pancreatic Extracts; Uric Acid | 1979 |
Iatrogenic hyperuricemia in children with cystic fibrosis.
Topics: Adolescent; Adult; Age Factors; Child; Cystic Fibrosis; Humans; Pancreas; Pancreatic Extracts; Purin | 1978 |
Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis.
Topics: Body Weight; Child; Cystic Fibrosis; Diet Therapy; Dietary Carbohydrates; Dietary Fats; Dietary Prot | 1977 |
Pancreatic extracts in the management of cystic fibrosis.
Topics: Cystic Fibrosis; Humans; Kidney Diseases; Pancreatic Extracts; Uric Acid | 1977 |
Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis.
Topics: Administration, Oral; Child, Preschool; Cystic Fibrosis; Humans; Male; Pancreatic Extracts; Pancreat | 1976 |
Uric acid serum concentrations in CF-children after pancreatic enzyme supplementation.
Topics: Adolescent; Adult; Child; Cystic Fibrosis; Female; Humans; Lipase; Male; Uric Acid | 1989 |