uric acid and Coma
uric acid has been researched along with Coma in 4 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This pharmacologic protection trial was conducted to test the hypothesis that allopurinol, a scavenger and inhibitor of oxygen free radical production, could reduce death, seizures, coma, and cardiac events in infants who underwent heart surgery using deep hypothermic circulatory arrest (DHCA)." | 5.09 | Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest. ( Clancy, RR; Gaynor, JW; Goin, JE; Hirtz, DG; Jacobs, ML; Mahle, WT; McGaurn, SA; Murphy, JD; Nicolson, SC; Norwood, WI; Spray, TL; Steven, JM; Wernovsky, G, 2001) |
| "We describe a patient with carnitine-acylcarnitine translocase deficiency (MIM 212138), who presented with neonatal generalized seizures, heart failure, and coma." | 3.70 | Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle. ( Dorland, L; Duran, M; IJlst, L; Muntau, AC; Roscher, AA; Röschinger, W; Wanders, RJ, 2000) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Röschinger, W | 1 |
| Muntau, AC | 1 |
| Duran, M | 1 |
| Dorland, L | 1 |
| IJlst, L | 1 |
| Wanders, RJ | 1 |
| Roscher, AA | 1 |
| Clancy, RR | 1 |
| McGaurn, SA | 1 |
| Goin, JE | 1 |
| Hirtz, DG | 1 |
| Norwood, WI | 1 |
| Gaynor, JW | 1 |
| Jacobs, ML | 1 |
| Wernovsky, G | 1 |
| Mahle, WT | 1 |
| Murphy, JD | 1 |
| Nicolson, SC | 1 |
| Steven, JM | 1 |
| Spray, TL | 1 |
| Gaab, M | 1 |
| Trost, HA | 1 |
| Pflughaupt, KW | 1 |
| Watschinger, B | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation[NCT02519335] | Phase 1 | 12 participants (Actual) | Interventional | 2014-09-30 | Terminated (stopped due to PI no longer at this facility) | ||
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery[NCT04997291] | Phase 1 | 12 participants (Anticipated) | Interventional | 2021-04-09 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
1 trial available for uric acid and Coma
| Article | Year |
|---|---|
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng | 2001 |
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng | 2001 |
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng | 2001 |
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng | 2001 |
Other Studies
3 other studies available for uric acid and Coma
| Article | Year |
|---|---|
Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle.
Topics: Ammonia; Cardiac Output, Low; Carnitine; Carnitine Acyltransferases; Cells, Cultured; Coma; Consangu | 2000 |
The prognostic value of osmolality within the first week of sustaining head injury.
Topics: Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Brain Injuries; Coma; Creatinine; Humans; Osmola | 1979 |
[Kidney and central nervous system].
Topics: Blood-Brain Barrier; Coma; Creatinine; Guanidines; Humans; Kidney Failure, Chronic; Neurologic Manif | 1971 |