Page last updated: 2024-10-20

uric acid and Coma

uric acid has been researched along with Coma in 4 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"This pharmacologic protection trial was conducted to test the hypothesis that allopurinol, a scavenger and inhibitor of oxygen free radical production, could reduce death, seizures, coma, and cardiac events in infants who underwent heart surgery using deep hypothermic circulatory arrest (DHCA)."5.09Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest. ( Clancy, RR; Gaynor, JW; Goin, JE; Hirtz, DG; Jacobs, ML; Mahle, WT; McGaurn, SA; Murphy, JD; Nicolson, SC; Norwood, WI; Spray, TL; Steven, JM; Wernovsky, G, 2001)
"We describe a patient with carnitine-acylcarnitine translocase deficiency (MIM 212138), who presented with neonatal generalized seizures, heart failure, and coma."3.70Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle. ( Dorland, L; Duran, M; IJlst, L; Muntau, AC; Roscher, AA; Röschinger, W; Wanders, RJ, 2000)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Röschinger, W1
Muntau, AC1
Duran, M1
Dorland, L1
IJlst, L1
Wanders, RJ1
Roscher, AA1
Clancy, RR1
McGaurn, SA1
Goin, JE1
Hirtz, DG1
Norwood, WI1
Gaynor, JW1
Jacobs, ML1
Wernovsky, G1
Mahle, WT1
Murphy, JD1
Nicolson, SC1
Steven, JM1
Spray, TL1
Gaab, M1
Trost, HA1
Pflughaupt, KW1
Watschinger, B1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation[NCT02519335]Phase 112 participants (Actual)Interventional2014-09-30Terminated (stopped due to PI no longer at this facility)
Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery[NCT04997291]Phase 112 participants (Anticipated)Interventional2021-04-09Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for uric acid and Coma

ArticleYear
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
    Pediatrics, 2001, Volume: 108, Issue:1

    Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scaveng

2001

Other Studies

3 other studies available for uric acid and Coma

ArticleYear
Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle.
    Clinica chimica acta; international journal of clinical chemistry, 2000, Volume: 298, Issue:1-2

    Topics: Ammonia; Cardiac Output, Low; Carnitine; Carnitine Acyltransferases; Cells, Cultured; Coma; Consangu

2000
The prognostic value of osmolality within the first week of sustaining head injury.
    Acta neurochirurgica. Supplementum, 1979, Volume: 28, Issue:1

    Topics: Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Brain Injuries; Coma; Creatinine; Humans; Osmola

1979
[Kidney and central nervous system].
    Wiener Zeitschrift fur Nervenheilkunde und deren Grenzgebiete, 1971, Volume: 29, Issue:1

    Topics: Blood-Brain Barrier; Coma; Creatinine; Guanidines; Humans; Kidney Failure, Chronic; Neurologic Manif

1971