uric acid has been researched along with Cognition Disorders in 34 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database." | 7.83 | Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline? ( Ham, JH; Lee, JJ; Lee, PH; Lee, WW; Sohn, YH; Ye, BS, 2016) |
| "High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes." | 7.74 | Cerebral ischemia mediates the effect of serum uric acid on cognitive function. ( Gordon, B; Jinnah, HA; Kraut, M; Schretlen, DJ; Vannorsdall, TD, 2008) |
| "The uric acid(UA) level was measured using automatic biochemical analyzer, and cognitive function was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Stroop color-word test." | 5.91 | Association between uric acid and cognitive dysfunction: A cross-sectional study with newly diagnosed, drug-naïve with bipolar disorder. ( Chen, J; Li, S; Lu, X; Qiu, Y; Tang, H; Teng, Z; Wang, B; Wu, H; Xiang, H; Xu, X; Zhao, Z, 2023) |
| "Hyperuricemia was defined as serum UA ≥7 mg/dl in men and ≥ 6 mg/dl in women." | 5.56 | The relationship between serum uric acid and cognitive function in patients with chronic heart failure. ( Lu, C; Niu, W; Yang, H, 2020) |
| "Uric acid has an anti-oxidative effect." | 5.42 | Association of serum uric acid level with cognitive function among patients with multiple system atrophy. ( Cao, B; Ou, R; Shang, HF; Wei, QQ; Yang, J, 2015) |
| "Uric acid is a risk factor of cardiovascular disease, as well as a major natural antioxidant, prohibiting the occurrence of cellular damage." | 5.35 | Serum uric acid and cognitive function and dementia. ( Breteler, MM; Euser, SM; Hofman, A; Westendorp, RG, 2009) |
| " Disturbance in purine metabolism pathway and a higher level of serum uric acid, called hyperuricemia, is a risk factor of CKD, and it has been linked to increased prevalence and progression of the disease." | 3.88 | Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment. ( Bhattacharjee, A; Borah, A; Mazumder, MK; Phukan, BC, 2018) |
| "The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database." | 3.83 | Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline? ( Ham, JH; Lee, JJ; Lee, PH; Lee, WW; Sohn, YH; Ye, BS, 2016) |
| " In ET patients, cognitive scores were correlated with serum levels of uric acid, education, tremor Rating Scale for Tremor-motor subscale score and depression levels (r = 0." | 3.80 | [Cognitive dysfuctions associated with essential tremor and Parkinson's disease]. ( Chen, J; Chen, Y; Liu, C; Mao, C; Wu, Y; Yao, J, 2014) |
| "High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes." | 3.74 | Cerebral ischemia mediates the effect of serum uric acid on cognitive function. ( Gordon, B; Jinnah, HA; Kraut, M; Schretlen, DJ; Vannorsdall, TD, 2008) |
| "A total of 104 patients with Parkinson's disease were divided into two groups: those with cognitive impairment and those without." | 2.74 | [Study on uric acid and the related factors associated with cognition in the patients with Parkinson's disease]. ( Liu, CF; Luo, WF; Mao, CJ; Wang, L; Wang, LJ; Wang, XJ, 2009) |
| "The uric acid(UA) level was measured using automatic biochemical analyzer, and cognitive function was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Stroop color-word test." | 1.91 | Association between uric acid and cognitive dysfunction: A cross-sectional study with newly diagnosed, drug-naïve with bipolar disorder. ( Chen, J; Li, S; Lu, X; Qiu, Y; Tang, H; Teng, Z; Wang, B; Wu, H; Xiang, H; Xu, X; Zhao, Z, 2023) |
| "Hyperuricemia was defined as serum UA ≥7 mg/dl in men and ≥ 6 mg/dl in women." | 1.56 | The relationship between serum uric acid and cognitive function in patients with chronic heart failure. ( Lu, C; Niu, W; Yang, H, 2020) |
| "Uric acid (UA) is a powerful antioxidant that may have neuroprotective properties, yet it is also a risk factor of vascular disease that predisposes individuals to cognitive impairment." | 1.46 | A Prospective Study on the Association between Uric Acid and Cognitive Function among Middle-Aged and Older Chinese. ( Sun, Y; Wang, T; Wu, Y; Zhai, L; Zhang, D, 2017) |
| "Uric acid (UA) is a purine metabolite that in most mammals is degraded by the hepatic enzyme uricase to allantoin." | 1.43 | Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans. ( Cen, X; Gao, F; Hu, J; Jie, H; Li, D; Li, Y; Lu, W; Shao, X; Zhao, Y; Zuo, Z, 2016) |
| "Uric acid (UA) has a contradictory effect on cognitive function and several lines of evidence suggest that UA may modulate outcome in neurological diseases." | 1.42 | Relation between uric acid and Alzheimer's disease in elderly Jordanians. ( Al-khateeb, E; Al-khateeb, M; Al-Musawi, H; Al-Shweiki, S; Althaher, A; Azzouqah, O; Shafagoj, Y, 2015) |
| "Uric acid has been associated as a risk factor for cardiovascular disease." | 1.42 | Lower uric Acid linked with cognitive dysfunction in the elderly. ( Arias-Carrión, O; Barraza-Salas, M; Cisneros-Martínez, J; Méndez-Hernández, E; Ruano-Calderón, L; Salas-Pacheco, J; Téllez-Valencia, A, 2015) |
| "Uric acid has an anti-oxidative effect." | 1.42 | Association of serum uric acid level with cognitive function among patients with multiple system atrophy. ( Cao, B; Ou, R; Shang, HF; Wei, QQ; Yang, J, 2015) |
| "Cognitive changes are common in Parkinson's disease (PD)." | 1.37 | Uric acid and cognition in Parkinson's disease: a follow-up study. ( Annanmaki, T; Hakkinen, P; Murros, K; Parviainen, T; Pohja, M, 2011) |
| "Uric acid is a risk factor of cardiovascular disease, as well as a major natural antioxidant, prohibiting the occurrence of cellular damage." | 1.35 | Serum uric acid and cognitive function and dementia. ( Breteler, MM; Euser, SM; Hofman, A; Westendorp, RG, 2009) |
| "Cognitive dysfunction is common in Parkinson's disease (PD)." | 1.35 | Uric acid associates with cognition in Parkinson's disease. ( Annanmaki, T; Hokkanen, L; Murros, K; Pessala-Driver, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 22 (64.71) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Fernández, JR | 1 |
| Sweet, ES | 1 |
| Welsh, WJ | 1 |
| Firestein, BL | 1 |
| Li, S | 1 |
| Lu, X | 2 |
| Qiu, Y | 1 |
| Teng, Z | 1 |
| Zhao, Z | 1 |
| Xu, X | 1 |
| Tang, H | 1 |
| Xiang, H | 1 |
| Chen, J | 2 |
| Wang, B | 1 |
| Wu, H | 1 |
| Niu, W | 1 |
| Yang, H | 1 |
| Lu, C | 1 |
| Wang, T | 1 |
| Wu, Y | 3 |
| Sun, Y | 1 |
| Zhai, L | 1 |
| Zhang, D | 2 |
| Mazumder, MK | 1 |
| Phukan, BC | 1 |
| Bhattacharjee, A | 1 |
| Borah, A | 1 |
| Al-khateeb, E | 1 |
| Althaher, A | 1 |
| Al-khateeb, M | 1 |
| Al-Musawi, H | 1 |
| Azzouqah, O | 1 |
| Al-Shweiki, S | 1 |
| Shafagoj, Y | 1 |
| Yao, J | 1 |
| Chen, Y | 1 |
| Mao, C | 1 |
| Liu, C | 1 |
| Vannorsdall, TD | 2 |
| Kueider, AM | 1 |
| Carlson, MC | 1 |
| Schretlen, DJ | 3 |
| Moccia, M | 1 |
| Lanzillo, R | 1 |
| Costabile, T | 1 |
| Russo, C | 1 |
| Carotenuto, A | 1 |
| Sasso, G | 1 |
| Postiglione, E | 1 |
| De Luca Picione, C | 1 |
| Vastola, M | 1 |
| Maniscalco, GT | 1 |
| Palladino, R | 1 |
| Brescia Morra, V | 1 |
| Molshatzki, N | 1 |
| Weinstein, G | 1 |
| Streifler, JY | 1 |
| Goldbourt, U | 1 |
| Tanne, D | 1 |
| Méndez-Hernández, E | 1 |
| Salas-Pacheco, J | 1 |
| Ruano-Calderón, L | 1 |
| Téllez-Valencia, A | 1 |
| Cisneros-Martínez, J | 1 |
| Barraza-Salas, M | 1 |
| Arias-Carrión, O | 1 |
| Zhang, L | 1 |
| Li, M | 1 |
| Zhan, L | 1 |
| Liang, L | 1 |
| Su, B | 1 |
| Sui, H | 1 |
| Gao, Z | 1 |
| Li, Y | 2 |
| Liu, Y | 1 |
| Wu, B | 1 |
| Liu, Q | 1 |
| Cao, B | 1 |
| Wei, QQ | 1 |
| Ou, R | 1 |
| Yang, J | 1 |
| Shang, HF | 1 |
| Ye, BS | 1 |
| Lee, WW | 1 |
| Ham, JH | 1 |
| Lee, JJ | 1 |
| Lee, PH | 1 |
| Sohn, YH | 1 |
| Beydoun, MA | 1 |
| Canas, JA | 1 |
| Dore, GA | 1 |
| Beydoun, HA | 1 |
| Rostant, OS | 1 |
| Fanelli-Kuczmarski, MT | 1 |
| Evans, MK | 1 |
| Zonderman, AB | 1 |
| Cheung, YT | 1 |
| Edelmann, MN | 1 |
| Mulrooney, DA | 1 |
| Green, DM | 1 |
| Chemaitilly, W | 1 |
| John, N | 1 |
| Robison, LL | 1 |
| Hudson, MM | 1 |
| Krull, KR | 1 |
| Shao, X | 1 |
| Lu, W | 1 |
| Gao, F | 1 |
| Li, D | 1 |
| Hu, J | 1 |
| Zuo, Z | 1 |
| Jie, H | 1 |
| Zhao, Y | 1 |
| Cen, X | 1 |
| Xiu, S | 1 |
| Zheng, Z | 1 |
| Guan, S | 1 |
| Zhang, J | 2 |
| Ma, J | 1 |
| Chan, P | 1 |
| Jinnah, HA | 2 |
| Gordon, B | 1 |
| Kraut, M | 1 |
| Euser, SM | 1 |
| Hofman, A | 1 |
| Westendorp, RG | 1 |
| Breteler, MM | 1 |
| Irizarry, MC | 1 |
| Raman, R | 1 |
| Schwarzschild, MA | 1 |
| Becerra, LM | 1 |
| Thomas, RG | 1 |
| Peterson, RC | 1 |
| Ascherio, A | 1 |
| Aisen, PS | 1 |
| Wang, XJ | 1 |
| Luo, WF | 1 |
| Wang, LJ | 1 |
| Mao, CJ | 1 |
| Wang, L | 1 |
| Liu, CF | 1 |
| Li, J | 1 |
| Dong, BR | 1 |
| Lin, P | 1 |
| Liu, GJ | 1 |
| Ceballos-Picot, I | 1 |
| Torres, RJ | 1 |
| Visser, JE | 1 |
| Verdu, A | 1 |
| Laróvere, LE | 1 |
| Chen, CJ | 1 |
| Cossu, A | 1 |
| Wu, CH | 1 |
| Sampat, R | 1 |
| Chang, SJ | 1 |
| de Kremer, RD | 1 |
| Nyhan, W | 1 |
| Harris, JC | 1 |
| Reich, SG | 1 |
| Puig, JG | 1 |
| Annanmaki, T | 2 |
| Pohja, M | 1 |
| Parviainen, T | 1 |
| Hakkinen, P | 1 |
| Murros, K | 2 |
| Afsar, B | 1 |
| Elsurer, R | 1 |
| Covic, A | 1 |
| Johnson, RJ | 1 |
| Kanbay, M | 1 |
| Maetzler, W | 1 |
| Stapf, AK | 1 |
| Schulte, C | 1 |
| Hauser, AK | 1 |
| Lerche, S | 1 |
| Wurster, I | 1 |
| Schleicher, E | 1 |
| Melms, A | 1 |
| Berg, D | 1 |
| Pang, Z | 1 |
| Jiang, W | 1 |
| Wang, S | 1 |
| Tan, Q | 1 |
| Rinaldi, P | 1 |
| Polidori, MC | 1 |
| Metastasio, A | 1 |
| Mariani, E | 1 |
| Mattioli, P | 1 |
| Cherubini, A | 1 |
| Catani, M | 1 |
| Cecchetti, R | 1 |
| Senin, U | 1 |
| Mecocci, P | 1 |
| Kim, TS | 1 |
| Pae, CU | 1 |
| Yoon, SJ | 1 |
| Jang, WY | 1 |
| Lee, NJ | 1 |
| Kim, JJ | 1 |
| Lee, SJ | 1 |
| Lee, C | 1 |
| Paik, IH | 1 |
| Lee, CU | 1 |
| Pessala-Driver, A | 1 |
| Hokkanen, L | 1 |
| Waugh, WH | 1 |
| Cameron, DE | 1 |
| Oettgen, HF | 1 |
| Stephenson, PA | 1 |
| Schwartz, MK | 1 |
| Leeper, RD | 1 |
| Tallai, L | 1 |
| Tan, CC | 1 |
| Clarkson, BD | 1 |
| Golbey, RB | 1 |
| Krakoff, IH | 1 |
| Karnofsky, DA | 1 |
| Murphy, ML | 1 |
| Burchenal, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vitamin D Status and Intakes and Their Association With Cognitive Trajectory in a Longitudinal Study of Urban Adults[NCT03320109] | 3,720 participants (Actual) | Observational | 2004-08-18 | Completed | |||
| Lutein Influence on Macula of Persons Issued From Amd Parents[NCT01269697] | Phase 3 | 120 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for uric acid and Cognition Disorders
| Article | Year |
|---|---|
Attenuated variants of Lesch-Nyhan disease.
Topics: Adolescent; Adult; Age of Onset; Aged; Child; Child, Preschool; Cognition Disorders; Cohort Studies; | 2010 |
Evolving concepts of memory.
Topics: Aged; Aspartate Aminotransferases; Blood Cell Count; Blood Sedimentation; Clinical Trials as Topic; | 1966 |
3 trials available for uric acid and Cognition Disorders
| Article | Year |
|---|---|
[Study on uric acid and the related factors associated with cognition in the patients with Parkinson's disease].
Topics: Aged; Cognition Disorders; Female; Humans; Male; Middle Aged; Parkinson Disease; Risk Factors; Uric | 2009 |
Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Apolipoproteins E; Ascorbic Acid; Caroteno | 2003 |
Evolving concepts of memory.
Topics: Aged; Aspartate Aminotransferases; Blood Cell Count; Blood Sedimentation; Clinical Trials as Topic; | 1966 |
30 other studies available for uric acid and Cognition Disorders
| Article | Year |
|---|---|
Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine.
Topics: Binding Sites; Cognition Disorders; Energy Metabolism; Guanine; Guanine Deaminase; Humans; Kinetics; | 2010 |
Association between uric acid and cognitive dysfunction: A cross-sectional study with newly diagnosed, drug-naïve with bipolar disorder.
Topics: Bipolar Disorder; Cognition Disorders; Cognitive Dysfunction; Cross-Sectional Studies; Female; Human | 2023 |
The relationship between serum uric acid and cognitive function in patients with chronic heart failure.
Topics: Aged; Aged, 80 and over; Biomarkers; Chronic Disease; Cognition; Cognition Disorders; Cross-Sectiona | 2020 |
A Prospective Study on the Association between Uric Acid and Cognitive Function among Middle-Aged and Older Chinese.
Topics: Aged; Aged, 80 and over; Asian People; Cognition; Cognition Disorders; Female; Humans; Linear Models | 2017 |
Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment.
Topics: Acetylcholinesterase; Catalytic Domain; Cognition Disorders; Computational Biology; Disease Progress | 2018 |
Relation between uric acid and Alzheimer's disease in elderly Jordanians.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Female; Geriatrics; Humans; Jordan; | 2015 |
[Cognitive dysfuctions associated with essential tremor and Parkinson's disease].
Topics: Cognition; Cognition Disorders; Depression; Depressive Disorder; Essential Tremor; Humans; Language; | 2014 |
Higher baseline serum uric acid is associated with poorer cognition but not rates of cognitive decline in women.
Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Cognition; Cognition Disorders; Cohort Studies; Cross-Se | 2014 |
Uric acid in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.
Topics: Adolescent; Adult; Analysis of Variance; Cognition Disorders; Disability Evaluation; Disease Progres | 2015 |
Serum uric acid and subsequent cognitive performance in patients with pre-existing cardiovascular disease.
Topics: Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Cognition Disorders; Female; Humans; Male; | 2015 |
Lower uric Acid linked with cognitive dysfunction in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Humans; Male; Mental Status Schedule; N | 2015 |
Plasma metabolomic profiling of patients with diabetes-associated cognitive decline.
Topics: Aged; Area Under Curve; Bile Acids and Salts; Biomarkers; Case-Control Studies; Chromatography, High | 2015 |
Association of serum uric acid level with cognitive function among patients with multiple system atrophy.
Topics: Aged; Analysis of Variance; Cognition Disorders; Female; Humans; Male; Middle Aged; Multiple System | 2015 |
Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition Disorders; Cognitive Dysfunction; | 2016 |
Serum Uric Acid and Its Association with Longitudinal Cognitive Change Among Urban Adults.
Topics: Adult; Age Factors; Attention; Cognition Disorders; Female; Humans; Longitudinal Studies; Male; Ment | 2016 |
Uric Acid and Neurocognitive Function in Survivors of Childhood Acute Lymphoblastic Leukemia Treated with Chemotherapy Only.
Topics: Adolescent; Adult; Antineoplastic Agents; Biomarkers; Cancer Survivors; Cardiovascular Diseases; Cog | 2016 |
Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans.
Topics: Administration, Oral; Animals; Cognition; Cognition Disorders; Cytokines; Encephalitis; Hippocampus; | 2016 |
Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing.
Topics: Aged; Aged, 80 and over; Aging; Beijing; Cognition; Cognition Disorders; Cross-Sectional Studies; Fe | 2017 |
Cerebral ischemia mediates the effect of serum uric acid on cognitive function.
Topics: Adult; Aged; Brain; Brain Edema; Brain Ischemia; Cognition Disorders; Female; Humans; Hyperuricemia; | 2008 |
Serum uric acid and cognitive function and dementia.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Cognition Disorders; Dementia; Female; Follow-Up Studies; | 2009 |
Plasma urate and progression of mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Boston; Cognition Disorders; Confounding Factors, Epidem | 2009 |
Association of cognitive function with serum uric acid level among Chinese nonagenarians and centenarians.
Topics: Aged; Aged, 80 and over; Asian People; Cognition Disorders; Cross-Sectional Studies; Female; Humans; | 2010 |
Uric acid and cognition in Parkinson's disease: a follow-up study.
Topics: Aged; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Ment | 2011 |
Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease.
Topics: Age Factors; Aged; Cerebrovascular Disorders; Cognition Disorders; Educational Status; Female; Human | 2011 |
Serum and cerebrospinal fluid uric acid levels in lewy body disorders: associations with disease occurrence and amyloid-β pathway.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; ATP Binding Cassette Transporter, Subfamily G, Membe | 2011 |
Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50-74 years.
Topics: Aged; Aging; China; Cognition; Cognition Disorders; Cross-Sectional Studies; Disease Progression; Fe | 2013 |
Decreased plasma antioxidants in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Bilirubin; Biomarkers; Cognition Disorders; Female; Humans; Male; Serum Alb | 2006 |
Uric acid associates with cognition in Parkinson's disease.
Topics: Choice Behavior; Cognition Disorders; Female; Humans; Linear Models; Male; Memory; Neuropsychologica | 2008 |
Inhibition of iron-catalyzed oxidations by attainable uric acid and ascorbic acid levels: therapeutic implications for Alzheimer's disease and late cognitive impairment.
Topics: Alzheimer Disease; Antioxidants; Ascorbic Acid; Cognition Disorders; Hemoglobins; Hydrogen Peroxide; | 2008 |
Toxicity of E. coli L-asparaginase in man.
Topics: Adult; Agranulocytosis; Antigen-Antibody Reactions; Asparaginase; Blood Platelet Disorders; Bone Mar | 1970 |