Page last updated: 2024-10-20

uric acid and Cataract

uric acid has been researched along with Cataract in 17 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"To examine the involvement of uric acid (UA) in the pathogenesis of posterior subcapsular cataract (PSC)."7.96Elevated level of uric acid in aqueous humour is associated with posterior subcapsular cataract in human lens. ( Chan, SO; Chen, YL; Chu, WK; Lin, HL; Niu, YY; Pang, CP; Qin, YJ; Xie, WJ; Zhang, HY; Zhang, YQ, 2020)
"High-performance liquid chromatography measured levels of uric acid and xanthine in aqueous humor samples of patients with retinoblastoma, melanoma, Coats' disease, adult cataract, and congenital cataract."7.70Uric acid in the aqueous humor and tears of retinoblastoma patients. ( Abramson, DH; Gamache, PH; Mendelsohn, ME; Senft, S; Servodidio, CA, 1998)
"Uric acid was marked by indirect method with uricase."6.68[Level of uric acid in aqueous humor of patients with cataract]. ( Kałuzny, J; Kałuzny, JJ; Raukuć, D, 1996)
"Uric acid was marked by indirect method with uricase."6.68[Uric acid level in aqueous humor of patients with cataract]. ( Kałuzny, J; Kałuzny, JJ; Raukuć, D, 1996)
"Uric acid, which is an endogenous antioxidant was statistically significantly decreased in the urine and plasma of SDZ ICT 322 VE/SeD treated rats."5.30Enhancement of SDZ ICT 322-induced cataracts and skin changes in rats following vitamin E- and selenium-deficient diet. ( Cordier, A; Längle, UW; Wolf, A, 1997)
"To examine the involvement of uric acid (UA) in the pathogenesis of posterior subcapsular cataract (PSC)."3.96Elevated level of uric acid in aqueous humour is associated with posterior subcapsular cataract in human lens. ( Chan, SO; Chen, YL; Chu, WK; Lin, HL; Niu, YY; Pang, CP; Qin, YJ; Xie, WJ; Zhang, HY; Zhang, YQ, 2020)
"The aim of this investigation was to assess and compare levels of uric acid in human tear fluid, aqueous humour and serum in cataract patients in order to obtain information about uric acid-dependent antioxidative status."3.75Determination of uric acid concentrations in human tear fluid, aqueous humour and serum. ( Faschinger, C; Horwath-Winter, J; Kirchengast, S; Meinitzer, A; Schmut, O; Wachswender, C, 2009)
"The levels of the two major primate UV filters, 3-hydroxykynurenine glucoside (3OHKG) and 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid glucoside (AHBG), in cataract lenses were markedly decreased compared with levels in normal lenses."3.72Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients. ( Jamie, JF; Streete, IM; Truscott, RJ, 2004)
"High-performance liquid chromatography measured levels of uric acid and xanthine in aqueous humor samples of patients with retinoblastoma, melanoma, Coats' disease, adult cataract, and congenital cataract."3.70Uric acid in the aqueous humor and tears of retinoblastoma patients. ( Abramson, DH; Gamache, PH; Mendelsohn, ME; Senft, S; Servodidio, CA, 1998)
"The concentration of the free aromatic amino acids tryptophan and tyrosine, the antioxidant uric acid and some unidentified compounds have been determined in the water-soluble extracts of parts from clear and nuclear-cataractous human lenses."3.67Distribution of aromatic and fluorescent compounds within single human lenses. ( Bessems, GJ; Hoenders, HJ, 1987)
"Uric acid was marked by indirect method with uricase."2.68[Level of uric acid in aqueous humor of patients with cataract]. ( Kałuzny, J; Kałuzny, JJ; Raukuć, D, 1996)
"Uric acid was marked by indirect method with uricase."2.68[Uric acid level in aqueous humor of patients with cataract]. ( Kałuzny, J; Kałuzny, JJ; Raukuć, D, 1996)
"Uric acid, which is an endogenous antioxidant was statistically significantly decreased in the urine and plasma of SDZ ICT 322 VE/SeD treated rats."1.30Enhancement of SDZ ICT 322-induced cataracts and skin changes in rats following vitamin E- and selenium-deficient diet. ( Cordier, A; Längle, UW; Wolf, A, 1997)
"Lens opacities were associated with lower levels of riboflavin, vitamin E, iron, and protein nutritional status."1.29Biochemical factors in the lens opacities. Case-control study. The Lens Opacities Case-Control Study Group. ( Ansari, N; Chylack, LT; Hyman, L; Leske, MC; Milton, RC; Sperduto, R; Srivastava, S; Underwood, B; Wu, SY, 1995)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19904 (23.53)18.7374
1990's8 (47.06)18.2507
2000's3 (17.65)29.6817
2010's0 (0.00)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Bouchemi, M1
Soualmia, H1
Midani, F1
El Afrit, MA1
El Asmi, M1
Feki, M1
Qin, YJ1
Chan, SO1
Lin, HL1
Zhang, YQ1
Chen, YL1
Niu, YY1
Xie, WJ1
Chu, WK1
Pang, CP1
Zhang, HY1
Horwath-Winter, J1
Kirchengast, S1
Meinitzer, A1
Wachswender, C1
Faschinger, C1
Schmut, O1
Streete, IM1
Jamie, JF1
Truscott, RJ1
Leske, MC1
Wu, SY1
Hyman, L1
Sperduto, R1
Underwood, B1
Chylack, LT1
Milton, RC1
Srivastava, S1
Ansari, N1
Kałuzny, J2
Kałuzny, JJ2
Raukuć, D2
Längle, UW1
Wolf, A1
Cordier, A1
Richer, SP1
Rose, RC1
Mendelsohn, ME1
Abramson, DH1
Senft, S1
Servodidio, CA1
Gamache, PH1
Aksoy, H1
Keles, S1
Koçer, I1
Akçay, F1
Bässler, KH1
Szczypka, M1
Gajewski, J1
Laskowska-Klita, T1
Zbieg-Sendecka, E1
Brás, A1
Monteiro, C1
Rueff, J1
Bessems, GJ1
Hoenders, HJ1
Paulson, GW1
Son, CD1
Nance, WE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Laser Species and Ocular Antioxidant Activity on Postoperative Inflammation and Visual Prognosis in Patients Undergoing Ophthalmic Surgery - a Comparative Study[NCT05905237]1,000 participants (Anticipated)Observational2022-07-12Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for uric acid and Cataract

ArticleYear
[Level of uric acid in aqueous humor of patients with cataract].
    Klinika oczna, 1996, Volume: 98, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Cataract; Female; Humans; Male; Middle Aged; Uric Aci

1996
[Uric acid level in aqueous humor of patients with cataract].
    Klinika oczna, 1996, Volume: 98, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Cataract; Female; Humans; Male; Middle Aged; Uric Aci

1996

Other Studies

15 other studies available for uric acid and Cataract

ArticleYear
Impaired nitric oxide production in patients with primary open-angle glaucoma.
    La Tunisie medicale, 2020, Volume: 98, Issue:2

    Topics: Aqueous Humor; Blood Chemical Analysis; Case-Control Studies; Cataract; Female; Glaucoma, Open-Angle

2020
Elevated level of uric acid in aqueous humour is associated with posterior subcapsular cataract in human lens.
    Clinical & experimental ophthalmology, 2020, Volume: 48, Issue:9

    Topics: Aqueous Humor; Cataract; Humans; Lens, Crystalline; Retrospective Studies; Uric Acid

2020
Determination of uric acid concentrations in human tear fluid, aqueous humour and serum.
    Acta ophthalmologica, 2009, Volume: 87, Issue:2

    Topics: Aged; Aged, 80 and over; Antioxidants; Aqueous Humor; Cataract; Chromatography, High Pressure Liquid

2009
Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients.
    Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Cataract; Chromatography, High Pressure Liquid; Glucosides; Humans;

2004
Biochemical factors in the lens opacities. Case-control study. The Lens Opacities Case-Control Study Group.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:9

    Topics: Adult; Aged; Amino Acids; Case-Control Studies; Cataract; Erythrocytes; Female; Glutathione Reductas

1995
Enhancement of SDZ ICT 322-induced cataracts and skin changes in rats following vitamin E- and selenium-deficient diet.
    Archives of toxicology, 1997, Volume: 71, Issue:5

    Topics: Animals; Body Weight; Cataract; Eating; Indoles; Male; Oxidative Stress; Rats; Rats, Wistar; Seleniu

1997
Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide.
    Vision research, 1998, Volume: 38, Issue:19

    Topics: Aged; Analysis of Variance; Animals; Antioxidants; Aqueous Humor; Ascorbic Acid; Cataract; Chromatog

1998
Uric acid in the aqueous humor and tears of retinoblastoma patients.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 1998, Volume: 2, Issue:6

    Topics: Adult; Aqueous Humor; Cataract; Chromatography, High Pressure Liquid; Humans; Infant; Melanoma; Reti

1998
Diabetic cataract and the total antioxidant status in aqueous humor.
    Clinical chemistry and laboratory medicine, 2001, Volume: 39, Issue:2

    Topics: Aged; Antioxidants; Aqueous Humor; Case-Control Studies; Cataract; Diabetes Mellitus, Type 2; Humans

2001
Absorption, metabolism, and tolerance of polyol sugar substitutes.
    Pharmacology and therapeutics in dentistry, 1978, Volume: 3, Issue:2-4

    Topics: Absorption; Cataract; Chemical Phenomena; Chemistry; Diarrhea; Glucuronates; Humans; Intestinal Abso

1978
Risk factors for age-related cortical, nuclear, and posterior subcapsular cataracts. The Italian-American Cataract Study Group.
    American journal of epidemiology, 1991, Mar-15, Volume: 133, Issue:6

    Topics: Adult; Age Factors; Aged; Case-Control Studies; Cataract; Confounding Factors, Epidemiologic; Cortis

1991
Red blood cells and serum antioxidant defense systems of galactosaemic children.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:10

    Topics: Antioxidants; Cataract; Ceruloplasmin; Child; Child, Preschool; Erythrocytes; Galactosemias; Humans;

1990
Oxidative stress in trisomy 21. A possible role in cataractogenesis.
    Ophthalmic paediatrics and genetics, 1989, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Ascorbic Acid; Cataract; Child; Child, Preschool; Down Syndrome; Erythrocytes; Fr

1989
Distribution of aromatic and fluorescent compounds within single human lenses.
    Experimental eye research, 1987, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Fluorescence;

1987
Neurologic aspects of typical and atypical Down's syndrome.
    Diseases of the nervous system, 1969, Volume: 30, Issue:9

    Topics: Cataract; Chromosome Aberrations; Down Syndrome; Gait; Humans; Hydroxyindoleacetic Acid; Intelligenc

1969