uric acid has been researched along with Brain Ischemia in 120 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of serum uric acid as a factor in the recurrence of ischemic stroke stays unclear." | 9.41 | Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis. ( Gao, Y; Li, M; Wang, H, 2023) |
| "We sought to assess a consecutive number of patients with first-ever acute ischemic stroke (AIS), the clinical relevance in regard to functional outcome of the serum uric acid (SUA) measured at admission." | 9.27 | U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke. ( Ding, L; Li, Y; Sheng, L; Wen, C; Xie, Z; Yang, Y; Zhang, Y, 2018) |
| "The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke remains debatable in human studies, and the sex effect on this association has yet to be explored." | 9.22 | Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial. ( Chen, LH; Geng, D; He, J; Ju, Z; Li, Q; Li, Y; Peng, H; Peng, Y; Wang, A; Wang, J; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2016) |
| "A study was undertaken to test in a subgroup reanalysis of the URICO-ICTUS trial whether uric acid is superior to placebo in improving the functional outcome in patients with acute stroke and hyperglycemia." | 9.20 | Uric acid improves glucose-driven oxidative stress in human ischemic stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Perez, B; Planas, AM; Renú, A; Torres, F; Vila, E, 2015) |
| "In the Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke (URICO-ICTUS) trial, 206 women and 205 men were randomized to UA 1000 mg or placebo." | 9.20 | Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Obach, V; Pérez, B; Planas, A; Renú, A; Urra, X; Vila, E, 2015) |
| "To determine whether the combined treatment with uric acid and rtPA is superior to rtPA alone in terms of clinical efficacy in acute ischaemic stroke patients treated within the first 4." | 9.14 | The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms. ( Amaro, S; Cánovas, D; Castellanos, M; Chamorro, A; Gállego, J; Martí-Fèbregas, J; Segura, T, 2010) |
| "The issue of whether serum uric acid (SUA) is associated with the outcome of acute ischemic stroke is controversial." | 9.01 | Serum Uric Acid Level and Outcome of Patients With Ischemic Stroke: A Systematic Review and Meta-Analysis. ( Cai, J; Hong, H; Lei, Z; Wang, Y, 2019) |
| "Previous studies assessing the association between serum uric acid levels and neurological outcome after acute ischemic stroke reported conflicting results." | 8.93 | Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke. ( Chen, Y; Li, C; Lin, Y; Liu, Y; Wang, B; Wang, Y; Wang, Z; Yan, S; Zhao, W, 2016) |
| "Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke." | 8.91 | The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature. ( Chen, J; Guo, Y; Huang, C; Li, R; Tan, S, 2015) |
| "Assessment and prognostic value of serum uric acid (SUA) and neuron-specific enolase (NSE) on the efficacy of intravenous thrombolytic therapy in cerebral infarction." | 8.31 | Assessment and prognostic value of serum uric acid and neuron-specific enolase on the efficacy of intravenous thrombolytic therapy in cerebral infarction. ( Liu, S; Shi, Y; Wang, S; Zang, Y; Zheng, H, 2023) |
| "Previous studies have found that uric acid (UA) plays a neuroprotective role in ischemic stroke patients." | 8.12 | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke. ( Li, X; Ma, A; Pan, X; Wei, J; Yin, R, 2022) |
| " Whereas Serum Uric acid acts as a marker of tissue infarction; indicating poor prognosis of ischemic stroke." | 8.12 | A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke. ( Bc, PK; Somannavar, VG, 2022) |
| "Higher serum levels of homocysteine, CRP, and Pro-BNP are associated with a higher risk of acute ischemic stroke." | 8.12 | Role of Serum Homocysteine, C-Reactive Protein (CRP), Uric Acid & Pro-Brain Natriuretic Peptide (Pro-BNP) in Predicting the Functional Outcome in Patients with Ischemic Stroke- A Prospective Observational Study from North India. ( Atam, V; Chauhan, H; Reddy, DH; Sawlani, KK, 2022) |
| "The role of uric acid as a risk factor for cerebrovascular disease, particularly acute ischemic stroke, is controversial and there is little information about this in our setting." | 8.12 | Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh. ( Hossain, MS; Jasmine, T; Kamrul-Hasan, AB; Rahman, MM; Saha, PK; Sarker, MA, 2022) |
| "Uric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models." | 7.96 | Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke. ( Cheng, Y; Liu, J; Liu, M; Song, Q; Wang, Y; Wei, C, 2020) |
| "According to the results of this study, uric acid medians in patients with stroke and controls were 4." | 7.96 | Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke. ( Ahmadi, Z; Amirabadizadeh, A; Mousavi-Mirzaei, SM; Nakhaee, S; Talebi, A, 2020) |
| "A total of 3284 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) with creatinine and uric acid measurements were included in this analysis." | 7.96 | Effect of renal function on association between uric acid and prognosis in acute ischemic stroke patients with elevated systolic blood pressure. ( Bu, X; Chen, J; Geng, D; Guo, D; He, J; Ju, Z; Peng, H; Peng, Y; Wang, A; Xu, T; Zhang, Y; Zheng, X; Zhong, C; Zhu, Z, 2020) |
| "Increased level of serum uric acid (SUA) is often considered a risk factor for ischemic stroke." | 7.96 | Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh. ( Al Mamun, MA; Barman, N; Haque, MA; Khalil, MI; Salwa, M; Sultana, S, 2020) |
| "The role of serum uric acid in ischemic stroke is controversial." | 7.91 | Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles Pérez-Monteoliva, NR, 2019) |
| "This was a hospital-based prospective cohort study that included patients with ischemic stroke with baseline uric acid levels and 3-month post-stroke follow-up data." | 7.88 | The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans. ( Ayeah, CM; Ba, H; Hentchoya, R; Luma, HN; Mapoure, YN, 2018) |
| "The relationship between serum uric acid (SUA) levels and stroke is controversial." | 7.88 | Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles, NR, 2018) |
| "Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke." | 7.88 | High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke. ( Lai, R; Li, JX; Sheng, WL; Sun, XS; Wang, YF, 2018) |
| "Uric acid (UA), an antioxidant with neuroprotective effects, favorably affects stroke outcome." | 7.88 | Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone. ( Ando, Y; Inatomi, Y; Naganuma, M; Nakajima, M; Yonehara, T, 2018) |
| "Preclinical and clinical studies support a promising, albeit not definitive, neuroprotective effect of emergent uric acid (UA) administration in ischemic stroke." | 7.88 | Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats. ( Aliena-Valero, A; Burguete, MC; Castelló-Ruiz, M; Chamorro, Á; Hervás, D; Jover-Mengual, T; Leira, EC; López-Morales, MA; Salom, JB; Torregrosa, G, 2018) |
| "Uric acid is a molecule that is known to act as a natural antioxidant in acute oxidative stress conditions such as acute ischemic stroke (AIS)." | 7.88 | Can high uric acid levels be an independent risk factor for acute ischemic stroke due to large-artery atherosclerosis? ( Acar, AB; Acar, T; Gül, SS; Güzey Aras, Y, 2018) |
| "The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection via activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and regulating neurotrophic factors in the cerebral cortices after transient focal cerebral ischemia/reperfusion (FCI/R) in rats." | 7.88 | Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression. ( Bai, B; Chen, L; Cheng, HJ; Li, HF; Li, WJ; Liu, Q; Liu, WY; Wang, Y; Ya, BL; Yu, T; Yuan, LL, 2018) |
| "Our aim was to investigate the association between serum uric acid (SUA) levels and the risk of first stroke in a Chinese population of hypertensive patients." | 7.85 | Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort. ( Cai, Y; Dong, Q; Fu, J; He, M; Huo, Y; Li, J; Qin, X; Shi, X; Tang, G; Wang, B; Wang, K; Wang, L; Xu, X; Yang, J; Zhang, C; Zhang, Y; Zhao, G; Zhao, M, 2017) |
| "An association between serum uric acid and outcomes of ischemic stroke has been reported, but the results are controversial." | 7.85 | Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke. ( Fukuda, H; Kawase, S; Kowa, H; Kusumi, M; Nakashima, K; Nakayasu, H; Suto, Y, 2017) |
| "The importance and function of serum uric acid (UA) levels in patients with cardiovascular disease or stroke are unclear." | 7.83 | Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients. ( Cao, YJ; Huang, ZC; Liu, CF; Lu, TS; You, SJ; Zhang, X, 2016) |
| "In matched analysis, risk of ischaemic stroke increased by 15% for each 1 mg/dl increase in plasma uric acid [95% confidence interval (CI) 3%-28%], but was no longer significant after adjustment for cardiovascular risk factors, particularly history of hypertension." | 7.83 | Plasma uric acid concentrations and risk of ischaemic stroke in women. ( Choi, HK; Curhan, GC; Forman, JP; Jiménez, MC; Rexrode, KM, 2016) |
| "Although high uric acid levels have been reported to be a risk factor for cardiovascular disease and stroke, the relationship between serum uric acid (SUA) levels and cardioembolic stroke (CES) has not been fully elucidated." | 7.83 | Association of serum uric acid and cardioembolic stroke in patients with acute ischemic stroke. ( Jung, S; Kim, CK; Kim, TJ; Kim, Y; Lee, SH; Yang, XL, 2016) |
| "No evidence is currently provided on the involvement of uric acid (UA) and Cu/Zn Superoxide Dismutase (Cu/Zn SOD) in functional recovery of stroke patients after neurorehabilitation." | 7.81 | Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation. ( Ciancarelli, I; De Amicis, D; Di Massimo, C; Pistarini, C; Tozzi Ciancarelli, MG, 2015) |
| "To evaluate the relation of serum uric acid levels on admission with short-term clinical outcome and hemorrhagic transformation (HT) in patients with acute ischemic stroke treated with thrombolysis." | 7.81 | [Association study of serum uric acid levels with clinical outcome and hemorrhagic transformation in stroke patients with rt-PA intravenous thrombolysis]. ( Cao, Y; Jiang, C; Liu, C; Shi, J; Xu, J; You, S; Yu, X, 2015) |
| "The relationship between uric acid and stroke prognosis is ambiguous." | 7.80 | Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patients. ( Jia, Q; Liu, G; Liu, L; Pu, Y; Wang, C; Wang, Y; Wu, H; Zhao, X, 2014) |
| "Current evidence shows that uric acid is a potent antioxidant whose serum concentration increases rapidly after acute ischemic stroke (AIS)." | 7.79 | Serum uric acid and outcome after acute ischemic stroke: PREMIER study. ( Arauz, A; Barinagarrementeria, F; Cantú-Brito, C; Chiquete, E; León-Jiménez, C; Murillo-Bonilla, LM; Ochoa-Guzmán, A; Orozco-Valera, DR; Ramos-Moreno, A; Ruiz-Sandoval, JL; Villarreal-Careaga, J, 2013) |
| "The prognostic value of serum uric acid (UA) in acute ischemic stroke is controversial." | 7.78 | Lack of association between serum uric acid levels and outcome in acute ischemic stroke. ( de Keyser, J; Koch, M; Kremer, B; Luijckx, GJ; Miedema, I; Uyttenboogaart, M, 2012) |
| "Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population." | 7.77 | Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients. ( Chen, Y; Ding, X; Fang, Y; Liu, Z; Shen, B; Teng, J; Wang, Y; Xu, S; Zhong, Y; Zou, J, 2011) |
| "Bilirubin (Bil) and uric acid (UA) are the endogenous antioxidant compounds possibly involved in the pathogenesis of ischemic stroke (IS)." | 7.75 | Serum bilirubin and uric acid levels as the bad prognostic factors in the ischemic stroke. ( Bartosik-Psujek, H; Bielewicz, J; Kurzepa, J; Stelmasiak, Z, 2009) |
| "High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes." | 7.74 | Cerebral ischemia mediates the effect of serum uric acid on cognitive function. ( Gordon, B; Jinnah, HA; Kraut, M; Schretlen, DJ; Vannorsdall, TD, 2008) |
| "The prognostic significance of uric acid (UA) levels in acute stroke is unclear, so the objective of this study was to determine the association between levels of serum UA (SUA) and mortality in acute stroke." | 7.74 | Serum uric acid as an independent predictor of early death after acute stroke. ( Athyros, VG; Gossios, T; Kakafika, A; Karagiannis, A; Krikis, N; Mikhailidis, DP; Moschou, I; Savvatianos, S; Sileli, M; Tziomalos, K; Xochellis, M, 2007) |
| "Since serum uric acid (UA) is strongly associated with cardiovascular risk factors, it has been debated whether serum UA is a stroke risk factor or whether UA may be simply "marking" subjects with other, causal risk factors." | 7.73 | Serum uric acid and risk of ischemic stroke: the ARIC Study. ( Folsom, AR; Hozawa, A; Ibrahim, H; Nieto, FJ; Rosamond, WD; Shahar, E, 2006) |
| "The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke." | 7.73 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. ( Bos, MJ; Breteler, MM; Hofman, A; Koudstaal, PJ; Witteman, JC, 2006) |
| "Uric acid is the end product of purine metabolism and a powerful water-soluble antioxidant and radical scavenger in humans whose generation is increased in situations of oxidative stress, such as brain ischemia." | 7.72 | Uric acid administration for neuroprotection in patients with acute brain ischemia. ( Chamorro, A; Deulofeu, R; Muner, DS; Planas, AM, 2004) |
| "We sought to assess in 881 consecutive patients with acute ischemic stroke the clinical relevance in regard to functional outcome of the natural antioxidant uric acid measured at hospital admission." | 7.71 | Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. ( Aponte, JH; Cervera, A; Chamorro, A; Deulofeu, R; Obach, V; Revilla, M, 2002) |
| "In this study, we examine the relationship between serum lipids and uric acid in nonembolic cerebral ischemia (NECI) patients." | 7.70 | The presentation of serum lipids and uric acid in cerebral ischemia. ( Chen, WH; Kao, YF; Liu, JS; Yin, HL, 1999) |
| "Changes in cerebral free amino acids, catecholamines and uric acid levels were explored for up to 7 days after cerebral ischemia in the rat." | 7.67 | [Biochemical studies of the cerebral ischemia in the rat--changes in cerebral free amino acids, catecholamines and uric acid]. ( Kaneko, D, 1986) |
| "Uric acid is an endogenous antioxidant making it a drug candidate to improve stroke outcomes." | 6.84 | Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy. ( Amaro, S; Arenillas, JF; Blasco, J; Cánovas, D; Castellanos, M; Chamorro, Á; Gomis, M; Leira, EC; Macho, J; Marti-Fabregas, J; Muñoz, R; Planas, AM; Román, LS; Urra, X, 2017) |
| "Uric acid was the leading metabolite in univariate analysis of both hyperglycemia (OR 19." | 5.62 | Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke. ( Acharjee, A; Ament, Z; Bevers, MB; Kimberly, WT; Wolcott, Z, 2021) |
| "Uric acid (UA) is an important endogenous free radical scavenger that has been found to have a neuroprotective effect." | 5.62 | Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy. ( Cui, T; Hao, Z; Wang, A; Wang, C; Wang, L; Wu, B; Yuan, Y; Zhu, Q, 2021) |
| "Uric acid has neuroprotective properties in experimental and clinical studies of neurodegenerative disease." | 5.48 | Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke. ( Liu, H; Reynolds, GP; Wang, W; Wei, X, 2018) |
| "After establishing middle cerebral artery occlusion of male rats with suture method, damage and increase of ROS production in brain tissue could be seen, and after adding suitable concentration of uric acid, the degree of brain damage and ROS production was reduced." | 5.46 | Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury. ( Lin, SP; Yang, N; Zhang, B; Zhang, F, 2017) |
| "Hyperglycemia was induced by i." | 5.46 | Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice. ( Castellví, C; Chamorro, Á; Deddens, LH; Dijkhuizen, RM; Justicia, C; Pérez-de-Puig, I; Planas, AM; Salas-Perdomo, A; van Tilborg, GAF, 2017) |
| "The role of serum uric acid as a factor in the recurrence of ischemic stroke stays unclear." | 5.41 | Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis. ( Gao, Y; Li, M; Wang, H, 2023) |
| "Uric acid (UA) is a strong endogenous antioxidant that neutralizes the toxicity of peroxynitrite and other reactive species on the neurovascular unit generated during and after acute brain ischemia." | 5.41 | Uric Acid: A Translational Journey in Cerebroprotection That Spanned Preclinical and Human Data. ( Chamorro, A; Chauhan, AK; Leira, EC; Planas, AM, 2023) |
| "Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke." | 5.34 | Serum uric acid and brain ischemia in normal elderly adults. ( Gordon, B; Inscore, AB; Jinnah, HA; Kraut, M; Pearlson, GD; Schretlen, DJ; Vannorsdall, TD, 2007) |
| " We report a post hoc analysis of the URICO-ICTUS trial (NCT00860366) assessing the modifying treatment effect of pretreatment collaterals on clinical and radiological outcomes in patients with large-vessel acute ischemic stroke receiving uric acid therapy or placebo." | 5.30 | Relevance of Collaterals for the Success of Neuroprotective Therapies in Acute Ischemic Stroke: Insights from the Randomized URICO-ICTUS Trial. ( Amaro, S; Arenillas, JF; Castellanos, M; Chamorro, Á; Laredo, C; Llull, L; Obach, V; Renú, A; Rudilloso, S; Urra, X, 2019) |
| "We sought to assess a consecutive number of patients with first-ever acute ischemic stroke (AIS), the clinical relevance in regard to functional outcome of the serum uric acid (SUA) measured at admission." | 5.27 | U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke. ( Ding, L; Li, Y; Sheng, L; Wen, C; Xie, Z; Yang, Y; Zhang, Y, 2018) |
| "The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke remains debatable in human studies, and the sex effect on this association has yet to be explored." | 5.22 | Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial. ( Chen, LH; Geng, D; He, J; Ju, Z; Li, Q; Li, Y; Peng, H; Peng, Y; Wang, A; Wang, J; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2016) |
| "A study was undertaken to test in a subgroup reanalysis of the URICO-ICTUS trial whether uric acid is superior to placebo in improving the functional outcome in patients with acute stroke and hyperglycemia." | 5.20 | Uric acid improves glucose-driven oxidative stress in human ischemic stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Perez, B; Planas, AM; Renú, A; Torres, F; Vila, E, 2015) |
| "In the Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke (URICO-ICTUS) trial, 206 women and 205 men were randomized to UA 1000 mg or placebo." | 5.20 | Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Obach, V; Pérez, B; Planas, A; Renú, A; Urra, X; Vila, E, 2015) |
| "To determine whether the combined treatment with uric acid and rtPA is superior to rtPA alone in terms of clinical efficacy in acute ischaemic stroke patients treated within the first 4." | 5.14 | The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms. ( Amaro, S; Cánovas, D; Castellanos, M; Chamorro, A; Gállego, J; Martí-Fèbregas, J; Segura, T, 2010) |
| "We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-alpha and interleukin-1beta, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF2alpha) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects." | 5.11 | Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. ( Dashe, JF; Folstein, MF; Martin, A; Sánchez-Moreno, C; Scott, T; Thaler, D, 2004) |
| "The issue of whether serum uric acid (SUA) is associated with the outcome of acute ischemic stroke is controversial." | 5.01 | Serum Uric Acid Level and Outcome of Patients With Ischemic Stroke: A Systematic Review and Meta-Analysis. ( Cai, J; Hong, H; Lei, Z; Wang, Y, 2019) |
| "Previous studies assessing the association between serum uric acid levels and neurological outcome after acute ischemic stroke reported conflicting results." | 4.93 | Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke. ( Chen, Y; Li, C; Lin, Y; Liu, Y; Wang, B; Wang, Y; Wang, Z; Yan, S; Zhao, W, 2016) |
| "Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke." | 4.91 | The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature. ( Chen, J; Guo, Y; Huang, C; Li, R; Tan, S, 2015) |
| "Assessment and prognostic value of serum uric acid (SUA) and neuron-specific enolase (NSE) on the efficacy of intravenous thrombolytic therapy in cerebral infarction." | 4.31 | Assessment and prognostic value of serum uric acid and neuron-specific enolase on the efficacy of intravenous thrombolytic therapy in cerebral infarction. ( Liu, S; Shi, Y; Wang, S; Zang, Y; Zheng, H, 2023) |
| "05 included blood pressure, uric acid, glucose level, triglyceride level, total cholesterol level, homocysteine level, duration of disease, and cerebral infarction site." | 4.31 | Factors influencing TCM syndrome types of acute cerebral infarction: A binomial logistic regression analysis. ( Yang, J; Zhang, S, 2023) |
| "Previous studies have found that uric acid (UA) plays a neuroprotective role in ischemic stroke patients." | 4.12 | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke. ( Li, X; Ma, A; Pan, X; Wei, J; Yin, R, 2022) |
| " Whereas Serum Uric acid acts as a marker of tissue infarction; indicating poor prognosis of ischemic stroke." | 4.12 | A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke. ( Bc, PK; Somannavar, VG, 2022) |
| "Higher serum levels of homocysteine, CRP, and Pro-BNP are associated with a higher risk of acute ischemic stroke." | 4.12 | Role of Serum Homocysteine, C-Reactive Protein (CRP), Uric Acid & Pro-Brain Natriuretic Peptide (Pro-BNP) in Predicting the Functional Outcome in Patients with Ischemic Stroke- A Prospective Observational Study from North India. ( Atam, V; Chauhan, H; Reddy, DH; Sawlani, KK, 2022) |
| "The role of uric acid as a risk factor for cerebrovascular disease, particularly acute ischemic stroke, is controversial and there is little information about this in our setting." | 4.12 | Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh. ( Hossain, MS; Jasmine, T; Kamrul-Hasan, AB; Rahman, MM; Saha, PK; Sarker, MA, 2022) |
| "The final model included seven independent predictors: gender, age, baseline National Institute of Health Stroke Scale (NIHSS), hypertension, diabetes mellitus, white blood cell and serum uric acid." | 4.02 | Prognostic nomogram for patients with minor stroke and transient ischaemic attack. ( Feng, H; Lai, Y; Lei, Z; Li, C; Li, S; Ren, L; Zhou, Y, 2021) |
| "Recent studies on uric acid as a biomarker for the prognosis of acute stroke have found conflicting results." | 4.02 | Hyperuricaemia as a prognostic factor for acute ischaemic stroke. ( Cabrera Naranjo, FH; Fabre Pi, O; González Hernández, A; Saavedra Santana, P; Sosa-Henríquez, M, 2021) |
| "Uric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models." | 3.96 | Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke. ( Cheng, Y; Liu, J; Liu, M; Song, Q; Wang, Y; Wei, C, 2020) |
| "According to the results of this study, uric acid medians in patients with stroke and controls were 4." | 3.96 | Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke. ( Ahmadi, Z; Amirabadizadeh, A; Mousavi-Mirzaei, SM; Nakhaee, S; Talebi, A, 2020) |
| "A total of 3284 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) with creatinine and uric acid measurements were included in this analysis." | 3.96 | Effect of renal function on association between uric acid and prognosis in acute ischemic stroke patients with elevated systolic blood pressure. ( Bu, X; Chen, J; Geng, D; Guo, D; He, J; Ju, Z; Peng, H; Peng, Y; Wang, A; Xu, T; Zhang, Y; Zheng, X; Zhong, C; Zhu, Z, 2020) |
| "Increased level of serum uric acid (SUA) is often considered a risk factor for ischemic stroke." | 3.96 | Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh. ( Al Mamun, MA; Barman, N; Haque, MA; Khalil, MI; Salwa, M; Sultana, S, 2020) |
| "The role of serum uric acid in ischemic stroke is controversial." | 3.91 | Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles Pérez-Monteoliva, NR, 2019) |
| "This was a hospital-based prospective cohort study that included patients with ischemic stroke with baseline uric acid levels and 3-month post-stroke follow-up data." | 3.88 | The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans. ( Ayeah, CM; Ba, H; Hentchoya, R; Luma, HN; Mapoure, YN, 2018) |
| "The relationship between serum uric acid (SUA) levels and stroke is controversial." | 3.88 | Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles, NR, 2018) |
| "Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke." | 3.88 | High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke. ( Lai, R; Li, JX; Sheng, WL; Sun, XS; Wang, YF, 2018) |
| "Uric acid (UA), an antioxidant with neuroprotective effects, favorably affects stroke outcome." | 3.88 | Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone. ( Ando, Y; Inatomi, Y; Naganuma, M; Nakajima, M; Yonehara, T, 2018) |
| "Preclinical and clinical studies support a promising, albeit not definitive, neuroprotective effect of emergent uric acid (UA) administration in ischemic stroke." | 3.88 | Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats. ( Aliena-Valero, A; Burguete, MC; Castelló-Ruiz, M; Chamorro, Á; Hervás, D; Jover-Mengual, T; Leira, EC; López-Morales, MA; Salom, JB; Torregrosa, G, 2018) |
| "Uric acid is a molecule that is known to act as a natural antioxidant in acute oxidative stress conditions such as acute ischemic stroke (AIS)." | 3.88 | Can high uric acid levels be an independent risk factor for acute ischemic stroke due to large-artery atherosclerosis? ( Acar, AB; Acar, T; Gül, SS; Güzey Aras, Y, 2018) |
| "The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection via activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and regulating neurotrophic factors in the cerebral cortices after transient focal cerebral ischemia/reperfusion (FCI/R) in rats." | 3.88 | Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression. ( Bai, B; Chen, L; Cheng, HJ; Li, HF; Li, WJ; Liu, Q; Liu, WY; Wang, Y; Ya, BL; Yu, T; Yuan, LL, 2018) |
| "Our aim was to investigate the association between serum uric acid (SUA) levels and the risk of first stroke in a Chinese population of hypertensive patients." | 3.85 | Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort. ( Cai, Y; Dong, Q; Fu, J; He, M; Huo, Y; Li, J; Qin, X; Shi, X; Tang, G; Wang, B; Wang, K; Wang, L; Xu, X; Yang, J; Zhang, C; Zhang, Y; Zhao, G; Zhao, M, 2017) |
| "An association between serum uric acid and outcomes of ischemic stroke has been reported, but the results are controversial." | 3.85 | Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke. ( Fukuda, H; Kawase, S; Kowa, H; Kusumi, M; Nakashima, K; Nakayasu, H; Suto, Y, 2017) |
| "The importance and function of serum uric acid (UA) levels in patients with cardiovascular disease or stroke are unclear." | 3.83 | Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients. ( Cao, YJ; Huang, ZC; Liu, CF; Lu, TS; You, SJ; Zhang, X, 2016) |
| "In matched analysis, risk of ischaemic stroke increased by 15% for each 1 mg/dl increase in plasma uric acid [95% confidence interval (CI) 3%-28%], but was no longer significant after adjustment for cardiovascular risk factors, particularly history of hypertension." | 3.83 | Plasma uric acid concentrations and risk of ischaemic stroke in women. ( Choi, HK; Curhan, GC; Forman, JP; Jiménez, MC; Rexrode, KM, 2016) |
| "Although high uric acid levels have been reported to be a risk factor for cardiovascular disease and stroke, the relationship between serum uric acid (SUA) levels and cardioembolic stroke (CES) has not been fully elucidated." | 3.83 | Association of serum uric acid and cardioembolic stroke in patients with acute ischemic stroke. ( Jung, S; Kim, CK; Kim, TJ; Kim, Y; Lee, SH; Yang, XL, 2016) |
| "No evidence is currently provided on the involvement of uric acid (UA) and Cu/Zn Superoxide Dismutase (Cu/Zn SOD) in functional recovery of stroke patients after neurorehabilitation." | 3.81 | Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation. ( Ciancarelli, I; De Amicis, D; Di Massimo, C; Pistarini, C; Tozzi Ciancarelli, MG, 2015) |
| "We demonstrated that 3-nitrotyrosine and 4-hydroxy-2-nonenal levels in mouse brain were elevated from 1 h until 8 h after global brain ischemia for 14 min induced with the 3-vessel occlusion model; this result indicates that ischemia reperfusion injury generated oxidative stress." | 3.81 | The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice. ( Fuse, A; Kusano, T; Matsuda, Y; Okamoto, K; Suzuki, G; Yamaguchi, M; Yokota, H, 2015) |
| "To evaluate the relation of serum uric acid levels on admission with short-term clinical outcome and hemorrhagic transformation (HT) in patients with acute ischemic stroke treated with thrombolysis." | 3.81 | [Association study of serum uric acid levels with clinical outcome and hemorrhagic transformation in stroke patients with rt-PA intravenous thrombolysis]. ( Cao, Y; Jiang, C; Liu, C; Shi, J; Xu, J; You, S; Yu, X, 2015) |
| "The relationship between uric acid and stroke prognosis is ambiguous." | 3.80 | Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patients. ( Jia, Q; Liu, G; Liu, L; Pu, Y; Wang, C; Wang, Y; Wu, H; Zhao, X, 2014) |
| "Current evidence shows that uric acid is a potent antioxidant whose serum concentration increases rapidly after acute ischemic stroke (AIS)." | 3.79 | Serum uric acid and outcome after acute ischemic stroke: PREMIER study. ( Arauz, A; Barinagarrementeria, F; Cantú-Brito, C; Chiquete, E; León-Jiménez, C; Murillo-Bonilla, LM; Ochoa-Guzmán, A; Orozco-Valera, DR; Ramos-Moreno, A; Ruiz-Sandoval, JL; Villarreal-Careaga, J, 2013) |
| "The prognostic value of serum uric acid (UA) in acute ischemic stroke is controversial." | 3.78 | Lack of association between serum uric acid levels and outcome in acute ischemic stroke. ( de Keyser, J; Koch, M; Kremer, B; Luijckx, GJ; Miedema, I; Uyttenboogaart, M, 2012) |
| "Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population." | 3.77 | Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients. ( Chen, Y; Ding, X; Fang, Y; Liu, Z; Shen, B; Teng, J; Wang, Y; Xu, S; Zhong, Y; Zou, J, 2011) |
| "Bilirubin (Bil) and uric acid (UA) are the endogenous antioxidant compounds possibly involved in the pathogenesis of ischemic stroke (IS)." | 3.75 | Serum bilirubin and uric acid levels as the bad prognostic factors in the ischemic stroke. ( Bartosik-Psujek, H; Bielewicz, J; Kurzepa, J; Stelmasiak, Z, 2009) |
| "High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes." | 3.74 | Cerebral ischemia mediates the effect of serum uric acid on cognitive function. ( Gordon, B; Jinnah, HA; Kraut, M; Schretlen, DJ; Vannorsdall, TD, 2008) |
| "The prognostic significance of uric acid (UA) levels in acute stroke is unclear, so the objective of this study was to determine the association between levels of serum UA (SUA) and mortality in acute stroke." | 3.74 | Serum uric acid as an independent predictor of early death after acute stroke. ( Athyros, VG; Gossios, T; Kakafika, A; Karagiannis, A; Krikis, N; Mikhailidis, DP; Moschou, I; Savvatianos, S; Sileli, M; Tziomalos, K; Xochellis, M, 2007) |
| "Since serum uric acid (UA) is strongly associated with cardiovascular risk factors, it has been debated whether serum UA is a stroke risk factor or whether UA may be simply "marking" subjects with other, causal risk factors." | 3.73 | Serum uric acid and risk of ischemic stroke: the ARIC Study. ( Folsom, AR; Hozawa, A; Ibrahim, H; Nieto, FJ; Rosamond, WD; Shahar, E, 2006) |
| "The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke." | 3.73 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. ( Bos, MJ; Breteler, MM; Hofman, A; Koudstaal, PJ; Witteman, JC, 2006) |
| "Uric acid is the end product of purine metabolism and a powerful water-soluble antioxidant and radical scavenger in humans whose generation is increased in situations of oxidative stress, such as brain ischemia." | 3.72 | Uric acid administration for neuroprotection in patients with acute brain ischemia. ( Chamorro, A; Deulofeu, R; Muner, DS; Planas, AM, 2004) |
| "We sought to assess in 881 consecutive patients with acute ischemic stroke the clinical relevance in regard to functional outcome of the natural antioxidant uric acid measured at hospital admission." | 3.71 | Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. ( Aponte, JH; Cervera, A; Chamorro, A; Deulofeu, R; Obach, V; Revilla, M, 2002) |
| "The purine metabolite hypoxanthine accumulates with hypoxia ischemia and with reperfusion is converted to uric acid (UA)." | 3.70 | Relationship of uric acid concentrations and severe intraventricular hemorrhage/leukomalacia in the premature infant. ( Perlman, JM; Risser, R, 1998) |
| "In this study, we examine the relationship between serum lipids and uric acid in nonembolic cerebral ischemia (NECI) patients." | 3.70 | The presentation of serum lipids and uric acid in cerebral ischemia. ( Chen, WH; Kao, YF; Liu, JS; Yin, HL, 1999) |
| " To further explore the possible role of XO, we examined the effect of various doses of allopurinol (5, 20, or 100 mg/kg given 1 h before MCAO or 100 mg/kg given 48, 24, and 1 h before MCAO) on uric acid accumulation, brain edema formation, and cerebral blood flow (CBF) 24 h after MCAO." | 3.68 | Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia. ( Betz, AL; Martz, D; Randall, J, 1991) |
| "Cerebral hypoxanthine, xanthine, and uric acid levels were measured by high-performance liquid chromatography (HPLC) for up to 4 hours following focal cerebral ischemia in the rat." | 3.67 | [Early changes of oxypurines in rat brain following focal cerebral ischemia]. ( Nihei, H, 1988) |
| "Changes in cerebral free amino acids, catecholamines and uric acid levels were explored for up to 7 days after cerebral ischemia in the rat." | 3.67 | [Biochemical studies of the cerebral ischemia in the rat--changes in cerebral free amino acids, catecholamines and uric acid]. ( Kaneko, D, 1986) |
| "Uric acid is an endogenous antioxidant making it a drug candidate to improve stroke outcomes." | 2.84 | Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy. ( Amaro, S; Arenillas, JF; Blasco, J; Cánovas, D; Castellanos, M; Chamorro, Á; Gomis, M; Leira, EC; Macho, J; Marti-Fabregas, J; Muñoz, R; Planas, AM; Román, LS; Urra, X, 2017) |
| "Uric acid levels were significantly reduced at both 7 days and 6 weeks in the high-dose group (by 0." | 2.73 | Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial. ( Dawson, J; Harrow, C; Lees, KR; Muir, SW; Sattar, N; Walters, MR; Weir, CJ, 2008) |
| "Uric acid (UA) has both antioxidative and pro-oxidative properties." | 1.72 | U-Shaped Association Between Serum Uric Acid and Hemorrhagic Transformation After Intravenous Thrombolysis. ( Chen, H; Cheng, Z; Fu, Y; Han, Z; Xia, L; Xu, T; Zhan, Z; Zhang, WY, 2022) |
| "Uric acid was the leading metabolite in univariate analysis of both hyperglycemia (OR 19." | 1.62 | Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke. ( Acharjee, A; Ament, Z; Bevers, MB; Kimberly, WT; Wolcott, Z, 2021) |
| "Uric acid (UA) is an important endogenous free radical scavenger that has been found to have a neuroprotective effect." | 1.62 | Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy. ( Cui, T; Hao, Z; Wang, A; Wang, C; Wang, L; Wu, B; Yuan, Y; Zhu, Q, 2021) |
| "Hyperuricemia was defined as the serum uric acid level of more than 6 mg/dl." | 1.56 | Association between Hyperuricemia and Ischemic Stroke: A Case-Control Study. ( Fatima, T; Iftikhar, S; Qureshi, IH, 2020) |
| "Uric acid has neuroprotective properties in experimental and clinical studies of neurodegenerative disease." | 1.48 | Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke. ( Liu, H; Reynolds, GP; Wang, W; Wei, X, 2018) |
| "Stroke is a growing disease and it is the second common cause of death in the world after coronary heart disease especially in the elderly." | 1.48 | Serum Uric Acid Levels and Serum Lipid Levels in Patients with Ischemic Cerebrovascular Accident. ( Arora, T; Bidri, RC; Mantur, PG; Mulimani, MS, 2018) |
| "After establishing middle cerebral artery occlusion of male rats with suture method, damage and increase of ROS production in brain tissue could be seen, and after adding suitable concentration of uric acid, the degree of brain damage and ROS production was reduced." | 1.46 | Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury. ( Lin, SP; Yang, N; Zhang, B; Zhang, F, 2017) |
| "Hyperglycemia was induced by i." | 1.46 | Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice. ( Castellví, C; Chamorro, Á; Deddens, LH; Dijkhuizen, RM; Justicia, C; Pérez-de-Puig, I; Planas, AM; Salas-Perdomo, A; van Tilborg, GAF, 2017) |
| "the bilirubin level was obviously lower while the ua level was significantly higher in the Sivd group when compared with the controls." | 1.40 | Serum antioxidant levels associated with subcortical ischemic vascular disease. ( Hao, J; Liu, H; Sun, Z; Wang, L; Zhang, C; Zhou, X; Zhu, M; Zhu, X, 2014) |
| "Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke." | 1.34 | Serum uric acid and brain ischemia in normal elderly adults. ( Gordon, B; Inscore, AB; Jinnah, HA; Kraut, M; Pearlson, GD; Schretlen, DJ; Vannorsdall, TD, 2007) |
| "Uric acid is a major antioxidant in the blood of humans that can protect cultured neurons against oxidative and metabolic insults." | 1.34 | Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice. ( Arumugam, TV; Cutler, RG; Greig, NH; Guo, Z; Haberman, F; Holloway, HW; Hyun, DH; Mattson, MP; Tang, SC; Yu, QS, 2007) |
| "Stroke is a leading cause of mortality and subsequent serious long-term physical and mental disability among survivors." | 1.33 | Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals. ( Bairaktari, ET; Elisaf, MS; Goudevenos, J; Liberopoulos, E; Milionis, HJ; Seferiadis, K, 2005) |
| "Uric acid was increased, whereas ascorbic acid and glutathione were correspondingly decreased." | 1.28 | Levels of low molecular weight scavengers in the rat brain during focal ischemia. ( Kabiersch, A; Kaeser, H; Landolt, H; Langemann, H; Lyrer, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (7.50) | 18.7374 |
| 1990's | 9 (7.50) | 18.2507 |
| 2000's | 26 (21.67) | 29.6817 |
| 2010's | 52 (43.33) | 24.3611 |
| 2020's | 24 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tian, Y | 2 |
| Xie, Q | 2 |
| You, J | 1 |
| Yang, S | 2 |
| Zhao, H | 3 |
| Song, Y | 2 |
| Wei, J | 1 |
| Yin, R | 1 |
| Li, X | 11 |
| Pan, X | 1 |
| Ma, A | 1 |
| Bc, PK | 1 |
| Somannavar, VG | 1 |
| Chauhan, H | 1 |
| Atam, V | 1 |
| Sawlani, KK | 1 |
| Reddy, DH | 1 |
| Rahman, MM | 3 |
| Kamrul-Hasan, AB | 1 |
| Jasmine, T | 1 |
| Hossain, MS | 1 |
| Saha, PK | 1 |
| Sarker, MA | 1 |
| Cheng, Z | 1 |
| Zhan, Z | 1 |
| Fu, Y | 2 |
| Zhang, WY | 1 |
| Xia, L | 1 |
| Xu, T | 5 |
| Chen, H | 2 |
| Han, Z | 1 |
| Li, M | 2 |
| Wang, H | 4 |
| Gao, Y | 3 |
| Zang, Y | 1 |
| Zheng, H | 1 |
| Liu, S | 1 |
| Wang, S | 3 |
| Shi, Y | 2 |
| Leira, EC | 3 |
| Planas, AM | 7 |
| Chauhan, AK | 1 |
| Chamorro, A | 14 |
| Zhang, S | 4 |
| Yang, J | 2 |
| Song, Q | 1 |
| Wang, Y | 9 |
| Cheng, Y | 1 |
| Liu, J | 1 |
| Wei, C | 1 |
| Liu, M | 1 |
| Ae, R | 1 |
| Kanbay, M | 1 |
| Kuwabara, M | 1 |
| Yuan, K | 1 |
| Zhang, X | 7 |
| Chen, J | 4 |
| Li, S | 3 |
| Yang, D | 2 |
| Xie, Y | 1 |
| Xia, Y | 1 |
| Wu, M | 4 |
| Xu, G | 1 |
| Liu, X | 2 |
| Talebi, A | 1 |
| Amirabadizadeh, A | 1 |
| Nakhaee, S | 1 |
| Ahmadi, Z | 1 |
| Mousavi-Mirzaei, SM | 1 |
| Liu, L | 4 |
| Huang, YQ | 1 |
| Lo, K | 1 |
| Tang, S | 2 |
| Feng, YQ | 1 |
| Zheng, X | 1 |
| Wang, A | 3 |
| Zhu, Z | 1 |
| Peng, Y | 2 |
| Peng, H | 2 |
| Zhong, C | 2 |
| Bu, X | 1 |
| Guo, D | 1 |
| Ju, Z | 2 |
| Geng, D | 2 |
| Zhang, Y | 9 |
| He, J | 3 |
| Khalil, MI | 2 |
| Salwa, M | 1 |
| Sultana, S | 1 |
| Al Mamun, MA | 1 |
| Barman, N | 1 |
| Haque, MA | 2 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 2 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 4 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 2 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 6 |
| Chen, L | 4 |
| Shan, A | 1 |
| Ma, Q | 1 |
| Wang, J | 5 |
| Zhang, E | 1 |
| Zhang, J | 4 |
| Li, Y | 7 |
| Xue, F | 1 |
| Deng, L | 1 |
| Yan, Z | 2 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Ren, Y | 1 |
| Li, J | 8 |
| Li, P | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset[NCT00860366] | Phase 2/Phase 3 | 421 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for uric acid and Brain Ischemia
| Article | Year |
|---|---|
Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis.
Topics: Brain Ischemia; Case-Control Studies; Humans; Ischemic Stroke; Risk Factors; Stroke; Uric Acid | 2023 |
Uric Acid: A Translational Journey in Cerebroprotection That Spanned Preclinical and Human Data.
Topics: Animals; Brain Ischemia; Female; Humans; Ischemic Stroke; Male; Mice; Microcirculation; Multicenter | 2023 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Serum Uric Acid Level and Outcome of Patients With Ischemic Stroke: A Systematic Review and Meta-Analysis.
Topics: Biomarkers; Brain Ischemia; Fibrinolytic Agents; Humans; Prognosis; Stroke; Thrombolytic Therapy; Ti | 2019 |
Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke.
Topics: Brain Ischemia; Humans; Publication Bias; Stroke; Treatment Outcome; Uric Acid | 2016 |
The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature.
Topics: Animals; Brain Ischemia; Fibrinolytic Agents; Humans; Neuroprotective Agents; PubMed; Stroke; Tissue | 2015 |
Administration of Uric Acid in the Emergency Treatment of Acute Ischemic Stroke.
Topics: Animals; Brain Ischemia; Emergency Treatment; Fibrinolytic Agents; Humans; Oxidative Stress; Stroke; | 2016 |
13 trials available for uric acid and Brain Ischemia
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy.
Topics: Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Stroke; T | 2017 |
U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke.
Topics: Aged; Brain Ischemia; Disease-Free Survival; Female; Humans; Male; Middle Aged; Prospective Studies; | 2018 |
Relevance of Collaterals for the Success of Neuroprotective Therapies in Acute Ischemic Stroke: Insights from the Randomized URICO-ICTUS Trial.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Cerebrovascular Circulation; Collateral Circulation; Double | 2019 |
Uric acid improves glucose-driven oxidative stress in human ischemic stroke.
Topics: Aged; Aged, 80 and over; Antioxidants; Blood Glucose; Brain Ischemia; Double-Blind Method; Female; H | 2015 |
Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke.
Topics: Aged; Aged, 80 and over; Antioxidants; Brain Ischemia; Double-Blind Method; Female; Humans; Male; Mi | 2015 |
Uric Acid Therapy Prevents Early Ischemic Stroke Progression: A Tertiary Analysis of the URICO-ICTUS Trial (Efficacy Study of Combined Treatment With Uric Acid and r-tPA in Acute Ischemic Stroke).
Topics: Antioxidants; Brain Ischemia; Double-Blind Method; Drug Therapy, Combination; Fibrinolytic Agents; H | 2016 |
Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial.
Topics: Adult; Aged; Brain Ischemia; China; Female; Humans; Male; Middle Aged; Prognosis; Risk Factors; Sex | 2016 |
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomark | 2008 |
The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms.
Topics: Adult; Aged; Biomarkers; Brain Ischemia; Clinical Protocols; Double-Blind Method; Drug Therapy, Comb | 2010 |
Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke.
Topics: Aged; Antioxidants; Ascorbic Acid; Biomarkers; Brain Ischemia; C-Reactive Protein; Chemokine CCL2; C | 2004 |
A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Double-Blind Method; Drug Therapy, Combination; Fibrinolyti | 2007 |
Antioxidant profile and early outcome in stroke patients.
Topics: Aged; Analysis of Variance; Antioxidants; Ascorbic Acid; Brain Ischemia; Chromatography, High Pressu | 2000 |
101 other studies available for uric acid and Brain Ischemia
| Article | Year |
|---|---|
Lower uric acid level may be associated with hemorrhagic transformation after intravenous thrombolysis.
Topics: Brain Ischemia; Humans; Ischemic Stroke; Retrospective Studies; Stroke; Thrombolytic Therapy; Uric A | 2022 |
Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke.
Topics: Brain Ischemia; Female; Humans; Ischemic Stroke; Male; Prevalence; Retrospective Studies; Stroke; Ur | 2022 |
A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Calcium; Child, Preschool; Cross-Sectional Studies; Female; Humans | 2022 |
Role of Serum Homocysteine, C-Reactive Protein (CRP), Uric Acid & Pro-Brain Natriuretic Peptide (Pro-BNP) in Predicting the Functional Outcome in Patients with Ischemic Stroke- A Prospective Observational Study from North India.
Topics: Adult; Aged; Biomarkers; Brain Ischemia; C-Reactive Protein; Embolic Stroke; Female; Homocysteine; H | 2022 |
Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh.
Topics: Bangladesh; Brain Ischemia; Cholesterol; Cross-Sectional Studies; Hospitals; Humans; Hypertension; H | 2022 |
U-Shaped Association Between Serum Uric Acid and Hemorrhagic Transformation After Intravenous Thrombolysis.
Topics: Brain Ischemia; Fibrinolytic Agents; Humans; Intracranial Hemorrhages; Ischemic Stroke; Retrospectiv | 2022 |
Assessment and prognostic value of serum uric acid and neuron-specific enolase on the efficacy of intravenous thrombolytic therapy in cerebral infarction.
Topics: Brain Ischemia; Cerebral Infarction; Fibrinolytic Agents; Humans; Phosphopyruvate Hydratase; Prognos | 2023 |
Factors influencing TCM syndrome types of acute cerebral infarction: A binomial logistic regression analysis.
Topics: Brain Ischemia; Cerebral Infarction; Cholesterol; Homocysteine; Humans; Logistic Models; Medicine, C | 2023 |
Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Strok | 2020 |
The causality between the serum uric acid level and stroke.
Topics: Brain Ischemia; Cardiovascular System; Humans; Stroke; Uric Acid | 2020 |
Uric acid level and risk of symptomatic intracranial haemorrhage in ischaemic stroke treated with endovascular treatment.
Topics: Brain Ischemia; Endovascular Procedures; Humans; Intracranial Hemorrhages; Ischemic Stroke; Thrombec | 2020 |
Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Cross-Sectional Studies; Femal | 2020 |
The association between serum uric acid levels and ischemic stroke in essential hypertension patients.
Topics: Biomarkers; Brain Ischemia; China; Essential Hypertension; Female; Humans; Kaplan-Meier Estimate; Ma | 2020 |
Effect of renal function on association between uric acid and prognosis in acute ischemic stroke patients with elevated systolic blood pressure.
Topics: Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Biomarkers; Blood Pressure; Blood Pressu | 2020 |
Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh.
Topics: Aged; Bangladesh; Brain Ischemia; Case-Control Studies; Female; Humans; Logistic Models; Male; Middl | 2020 |
Association between Hyperuricemia and Ischemic Stroke: A Case-Control Study.
Topics: Brain Ischemia; Case-Control Studies; Humans; Hyperuricemia; Ischemic Stroke; Risk Factors; Stroke; | 2020 |
Prognostic nomogram for patients with minor stroke and transient ischaemic attack.
Topics: Adult; Aged; Brain Ischemia; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Nomogram | 2021 |
Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke.
Topics: Brain Ischemia; Gluconates; Humans; Hyperglycemia; Laboratories, Clinical; Stroke; Uric Acid | 2021 |
Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Humans; Ischemic Stroke; Male; Middle Aged; Prognos | 2021 |
Higher uric acid is associated with better discharge recovery and short-term outcome in stroke patients treated with thrombolysis.
Topics: Brain Ischemia; Humans; Patient Discharge; Prognosis; Retrospective Studies; Stroke; Thrombolytic Th | 2021 |
Relationship between serum uric acid and ischemic stroke in a large type 2 diabetes population in China: A cross-sectional study.
Topics: Age Factors; Aged; Biomarkers; Brain Ischemia; China; Cross-Sectional Studies; Diabetes Mellitus, Ty | 2017 |
Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort.
Topics: Aged; Blood Pressure; Brain Ischemia; China; Diastole; Female; Follow-Up Studies; Humans; Hypertensi | 2017 |
Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Chi-Square Distribu | 2017 |
The impact of acute kidney injury on in-hospital mortality in acute ischemic stroke patients undergoing intravenous thrombolysis.
Topics: Acute Kidney Injury; Administration, Intravenous; Aged; Biomarkers; Brain Ischemia; Female; Fibrinol | 2017 |
The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans.
Topics: Aged; Biomarkers; Black People; Brain Ischemia; Cameroon; Chi-Square Distribution; Female; Humans; H | 2018 |
Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Mal | 2018 |
Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Cerebrovascular Circulation; Cohort Studies; Cross-Sectional Studi | 2018 |
Hyperuricaemia as a prognostic factor for acute ischaemic stroke.
Topics: Brain Ischemia; Humans; Hyperuricemia; Ischemic Stroke; Prognosis; Stroke; United States; Uric Acid | 2021 |
High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke.
Topics: Brain Ischemia; Demography; Female; Humans; Male; Prognosis; Sex Characteristics; Stroke; Treatment | 2018 |
Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Disability Evaluation; Edaravone; Female; Free | 2018 |
Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats.
Topics: Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Female; Male; Mec | 2018 |
Can high uric acid levels be an independent risk factor for acute ischemic stroke due to large-artery atherosclerosis?
Topics: Atherosclerosis; Bilirubin; Biomarkers; Brain Ischemia; Carotid Intima-Media Thickness; Carotid Sten | 2018 |
Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Carotid Intima-Media Thickness; Carotid Stenosi | 2019 |
Uric acid enhances longevity and endurance and protects the brain against ischemia.
Topics: Animals; Brain; Brain Ischemia; Humans; Longevity; Mice, Transgenic; Oxidative Stress; Stroke; Uric | 2019 |
Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blotting, Western; Brain Ischemia; Cerebral Infarction; Deoxyg | 2018 |
Serum Uric Acid Levels and Serum Lipid Levels in Patients with Ischemic Cerebrovascular Accident.
Topics: Aged; Brain Ischemia; Cholesterol, HDL; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Lipi | 2018 |
Serum uric acid and outcome after acute ischemic stroke: PREMIER study.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Chi-Square Distribution; Disability Eval | 2013 |
Association of serum uric acid with ischemic stroke.
Topics: Aged; Brain Ischemia; Comorbidity; Female; Humans; Logistic Models; Male; Middle Aged; Risk Factors; | 2013 |
Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patients.
Topics: Aged; Biomarkers; Brain Ischemia; Cerebral Hemorrhage; China; Down-Regulation; Female; Humans; Kapla | 2014 |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study.
Topics: Aged; Biomarkers; Brain Ischemia; Cohort Studies; Female; Humans; Male; Middle Aged; Norway; Populat | 2013 |
Serum antioxidant levels associated with subcortical ischemic vascular disease.
Topics: Aged; Antioxidants; Bilirubin; Biomarkers; Brain Ischemia; Cross-Sectional Studies; Dementia, Vascul | 2014 |
Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation.
Topics: Aged; Biomarkers; Brain Ischemia; Female; Humans; Male; Recovery of Function; Stroke; Stroke Rehabil | 2015 |
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice.
Topics: Aldehydes; Allopurinol; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Interleu | 2015 |
Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain Ischemia; Chi-Square Distrib | 2016 |
Response to Letter Regarding Article, "Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke".
Topics: Antioxidants; Brain Ischemia; Female; Humans; Male; Stroke; Uric Acid | 2015 |
Letter by Heo et al Regarding Article, "Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke".
Topics: Antioxidants; Brain Ischemia; Female; Humans; Male; Stroke; Uric Acid | 2015 |
Low Serum Levels of Uric Acid are Associated With Development of Poststroke Depression.
Topics: Aged; Brain Ischemia; Case-Control Studies; Depressive Disorder; Female; Humans; Male; Middle Aged; | 2015 |
[Association study of serum uric acid levels with clinical outcome and hemorrhagic transformation in stroke patients with rt-PA intravenous thrombolysis].
Topics: Administration, Intravenous; Brain Ischemia; Fibrinolytic Agents; Humans; Incidence; Intracranial He | 2015 |
Plasma uric acid concentrations and risk of ischaemic stroke in women.
Topics: Adult; Aged; Brain Ischemia; Case-Control Studies; Cohort Studies; Female; Humans; Hypertension; Mid | 2016 |
Plasma uric acid and risk of ischaemic stroke in women.
Topics: Brain Ischemia; Case-Control Studies; Female; Humans; Risk; Risk Factors; Stroke; Uric Acid | 2016 |
Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Line; Cell Proliferation; Cell Survival; Disease Mod | 2017 |
Association of serum uric acid and cardioembolic stroke in patients with acute ischemic stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Cardiovascular Diseases; Female; Humans; Intracranial Embolism; Lo | 2016 |
Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Hyperglycemia; Intercellular Adhesion Molecule- | 2017 |
Response to comment on plasma uric acid and risk of ischaemic stroke in women.
Topics: Biomarkers; Brain Ischemia; Female; Humans; Risk; Risk Factors; Stroke; Uric Acid | 2017 |
Cerebral ischemia mediates the effect of serum uric acid on cognitive function.
Topics: Adult; Aged; Brain; Brain Edema; Brain Ischemia; Cognition Disorders; Female; Humans; Hyperuricemia; | 2008 |
Baseline serum urate and 90-day functional outcomes following acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Female; Humans; Logistic Models; Male; Middle A | 2009 |
Serum bilirubin and uric acid levels as the bad prognostic factors in the ischemic stroke.
Topics: Aged; Analysis of Variance; Bilirubin; Brain Ischemia; Disability Evaluation; Female; Humans; Male; | 2009 |
Decrease in uric acid in acute ischemic stroke correlates with stroke severity, evolution and outcome.
Topics: Acute Disease; Aged; Aged, 80 and over; Brain Ischemia; Disease Progression; Female; Humans; Kinetic | 2010 |
Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients.
Topics: Adult; Age Factors; Aged; Brain Ischemia; Female; Humans; Inflammation; Kidney Failure, Chronic; Mal | 2011 |
Serum uri acid: neuroprotection in thrombolysis. The Bergen NORSTROKE study.
Topics: Aged; Brain Ischemia; Female; Humans; Male; Neuroprotective Agents; Norway; Outcome and Process Asse | 2011 |
Lack of association between serum uric acid levels and outcome in acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Humans; Male; Middle Aged; Predictive Value of Test | 2012 |
24-h residual urine volume at hemodialysis initiation: a possible predictor for acute ischemic stroke incurrence in hemodialysis patients.
Topics: Age Factors; Aged; Brain Ischemia; Cerebral Infarction; Data Interpretation, Statistical; Diabetes C | 2013 |
Highly selective electrochemical strategy for monitoring of cerebral Cu2+ based on a carbon Dot-TPEA hybridized surface.
Topics: Amino Acids; Animals; Ascorbic Acid; Brain Ischemia; Carbon; Cerebral Cortex; Copper; Electrochemica | 2013 |
Lack of association between serum uric acid levels and outcome in acute ischemic stroke.
Topics: Brain Ischemia; Female; Humans; Male; Recovery of Function; Stroke; Uric Acid | 2013 |
Editorial comment--Elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective.
Topics: Animals; Antioxidants; Brain Ischemia; Causality; Humans; Hypertension; Hyperuricemia; Neuroprotecti | 2003 |
Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke.
Topics: Acute Disease; Aged; Brain Ischemia; Cerebral Hemorrhage; Female; Follow-Up Studies; Humans; Ischemi | 2003 |
Uric acid administration for neuroprotection in patients with acute brain ischemia.
Topics: Acute Disease; Animals; Antioxidants; Brain Ischemia; Evidence-Based Medicine; Humans; Neuroprotecti | 2004 |
Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia.
Topics: Animals; Antioxidants; Arachidonic Acid; Ascorbic Acid; Brain; Brain Ischemia; Dinoprostone; Disease | 2005 |
Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals.
Topics: Acute Disease; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Cholesterol; Female; F | 2005 |
Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects.
Topics: Aged; Apolipoprotein A-I; Brain Ischemia; Case-Control Studies; Cholesterol; Cholesterol, HDL; Diabe | 2005 |
Serum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly subjects.
Topics: Aged; Body Mass Index; Brain Ischemia; Case-Control Studies; Female; Humans; Hypertension; Lipids; M | 2005 |
Serum uric acid and risk of ischemic stroke: the ARIC Study.
Topics: Biomarkers; Brain Ischemia; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Pre | 2006 |
Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study.
Topics: Aged; Brain Ischemia; Cardiovascular Diseases; Case-Control Studies; Cerebral Hemorrhage; Cohort Stu | 2006 |
Serum uric acid as an independent predictor of early death after acute stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Cerebral Hemorrhage; Cohort Studies; Female; Hospital Morta | 2007 |
Serum uric acid and brain ischemia in normal elderly adults.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brain; Brain Ischemia; Cohort Studies; Cross-Sectional S | 2007 |
Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice.
Topics: Animals; Antioxidants; Blood Flow Velocity; Brain Injuries; Brain Ischemia; Cell Culture Techniques; | 2007 |
Uric acid: neuroprotective or neurotoxic?
Topics: Animals; Antioxidants; Brain Ischemia; Gout; Humans; Hyperuricemia; Lesch-Nyhan Syndrome; Neuroprote | 2008 |
Reversible cerebral ischemias: a comparative analysis of risk factors in TIAs and in RINDs.
Topics: Atrial Fibrillation; Brain Ischemia; Female; Hematocrit; Humans; Hypercholesterolemia; Hypertension; | 1984 |
Stroke and alcohol intake in a hospital population. A case-control study.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholism; Aspartate Aminotransferases; Biomarker | 1995 |
HPLC method for measurement of purine nucleotide degradation products in cerebrospinal fluid.
Topics: Adult; Brain Ischemia; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hyp | 1996 |
Microdialytic monitoring during cerebrovascular surgery.
Topics: Ascorbic Acid; Biomarkers; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Internal; Cerebr | 1996 |
Relationship of uric acid concentrations and severe intraventricular hemorrhage/leukomalacia in the premature infant.
Topics: Birth Weight; Brain Ischemia; Cerebral Hemorrhage; Gestational Age; Humans; Hypoxia; Infant, Newborn | 1998 |
The presentation of serum lipids and uric acid in cerebral ischemia.
Topics: Aged; Brain Ischemia; Carbohydrate Metabolism; Female; Humans; Lipids; Male; Middle Aged; Triglyceri | 1999 |
Chronic effects of an aminosteroid on microdialytically measured parameters after experimental middle cerebral artery occlusion in the rat.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Drug Evaluation, Preclinical; Free Radicals; Glucose; Infarc | 2000 |
Hypoxanthine, uric acid and allantoin as indicators of in vivo free radical reactions. Description of a HPLC method and human brain microdialysis data.
Topics: Allantoin; Biomarkers; Brain Ischemia; Chromatography, High Pressure Liquid; Female; Free Radicals; | 2000 |
The effect of allopurinol on focal cerebral ischaemia: an experimental study in rabbits.
Topics: Allopurinol; Animals; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Chromatography, High Pressu | 2001 |
Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis.
Topics: Adolescent; Brain Ischemia; Child; Child, Preschool; Female; Humans; Infant; Male; Nucleosides; Nucl | 2001 |
Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke.
Topics: Acute Disease; Age Factors; Aged; Antioxidants; Blood Glucose; Blood Sedimentation; Brain Ischemia; | 2002 |
Lp(a), homocysteine and a family history of early ischemic cerebral stroke.
Topics: Adolescent; Adult; Brain Ischemia; Factor VII; Female; Fibrinogen; Genetic Predisposition to Disease | 2001 |
Critical plasma pentobarbital levels in the treatment of acute ischemic stroke.
Topics: Animals; Brain Ischemia; Cats; Cerebrovascular Disorders; Electrocardiography; Pentobarbital; Serum | 1979 |
Low-molecular nitrogenous substances in the cerebrospinal fluid in focal ischemia and brain tumors.
Topics: Ammonia; Brain Ischemia; Brain Neoplasms; Humans; Molecular Weight; Nitrogen; Urea; Uric Acid | 1978 |
Change of xanthine dehydrogenase and xanthine oxidase activities in rat brain following complete ischaemia.
Topics: Animals; Brain Ischemia; Male; Prosencephalon; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Dehyd | 1992 |
Extracellular antioxidants and amino acids in the cortex of the rat: monitoring by microdialysis of early ischemic changes.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Cerebral Cortex; Cysteine; Dialysis; Extracellular Space; Gl | 1992 |
Levels of low molecular weight scavengers in the rat brain during focal ischemia.
Topics: Amino Acids; Animals; Ascorbic Acid; Brain Chemistry; Brain Ischemia; Cerebral Arteries; Cysteine; F | 1991 |
Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia.
Topics: Allopurinol; Animals; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dose-Response | 1991 |
Lipid peroxidation in focal cerebral ischemia.
Topics: Animals; Ascorbic Acid; Brain; Brain Ischemia; Lipid Peroxides; Male; Rats; Rats, Inbred Strains; Ub | 1989 |
[Xanthine oxidoreductase activity in rat brain tissue: the changes after decapitation].
Topics: Allopurinol; Animals; Brain; Brain Ischemia; In Vitro Techniques; Ketone Oxidoreductases; Male; Rats | 1989 |
Allopurinol inhibits uric acid accumulation in the rat brain following focal cerebral ischemia.
Topics: Allopurinol; Animals; Brain; Brain Ischemia; Male; Rats; Rats, Inbred Strains; Uric Acid | 1989 |
[Early changes of oxypurines in rat brain following focal cerebral ischemia].
Topics: Animals; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Hypoxanthine; Hypoxanthines; M | 1988 |
[Biochemical studies of the cerebral ischemia in the rat--changes in cerebral free amino acids, catecholamines and uric acid].
Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Catecholamines; Citric Acid Cycle; | 1986 |
Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries.
Topics: Adenine; Allopurinol; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Ischemia; Cap | 1985 |