uric acid has been researched along with Brain Edema in 9 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite the promising neuroprotective effects of uric acid (UA) in acute ischemic stroke, the seemingly pleiotropic underlying mechanisms are not completely understood." | 8.02 | Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke. ( Aliena-Valero, A; Baixauli-Martín, J; Chamorro, Á; Pérez, S; Rius-Pérez, S; Salom, JB; Torregrosa, G, 2021) |
| "High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes." | 7.74 | Cerebral ischemia mediates the effect of serum uric acid on cognitive function. ( Gordon, B; Jinnah, HA; Kraut, M; Schretlen, DJ; Vannorsdall, TD, 2008) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 5.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "Despite the promising neuroprotective effects of uric acid (UA) in acute ischemic stroke, the seemingly pleiotropic underlying mechanisms are not completely understood." | 4.02 | Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke. ( Aliena-Valero, A; Baixauli-Martín, J; Chamorro, Á; Pérez, S; Rius-Pérez, S; Salom, JB; Torregrosa, G, 2021) |
| "High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes." | 3.74 | Cerebral ischemia mediates the effect of serum uric acid on cognitive function. ( Gordon, B; Jinnah, HA; Kraut, M; Schretlen, DJ; Vannorsdall, TD, 2008) |
| " To further explore the possible role of XO, we examined the effect of various doses of allopurinol (5, 20, or 100 mg/kg given 1 h before MCAO or 100 mg/kg given 48, 24, and 1 h before MCAO) on uric acid accumulation, brain edema formation, and cerebral blood flow (CBF) 24 h after MCAO." | 3.68 | Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia. ( Betz, AL; Martz, D; Randall, J, 1991) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 1.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Aliena-Valero, A | 1 |
| Rius-Pérez, S | 1 |
| Baixauli-Martín, J | 1 |
| Torregrosa, G | 1 |
| Chamorro, Á | 2 |
| Pérez, S | 1 |
| Salom, JB | 1 |
| Vannorsdall, TD | 1 |
| Jinnah, HA | 1 |
| Gordon, B | 1 |
| Kraut, M | 1 |
| Schretlen, DJ | 1 |
| Romanos, E | 1 |
| Planas, AM | 1 |
| Amaro, S | 1 |
| Landolt, H | 2 |
| Langemann, H | 2 |
| Probst, A | 1 |
| Gratzl, O | 2 |
| Mendelowitsch, A | 1 |
| Mayatepek, E | 1 |
| Koch, HG | 1 |
| Hoffmann, GF | 1 |
| Betz, AL | 1 |
| Randall, J | 1 |
| Martz, D | 1 |
| Ogawa, T | 1 |
| Gitsch, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset[NCT00860366] | Phase 2/Phase 3 | 421 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for uric acid and Brain Edema
| Article | Year |
|---|---|
Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Brain Edema; Brain Infarction; Cytokines; Gene Expres | 2021 |
Cerebral ischemia mediates the effect of serum uric acid on cognitive function.
Topics: Adult; Aged; Brain; Brain Edema; Brain Ischemia; Cognition Disorders; Female; Humans; Hyperuricemia; | 2008 |
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Humans; Infarction, Middle Cerebral Artery; Male; Neuro | 2007 |
Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue.
Topics: Adult; Aged; Antioxidants; Artifacts; Ascorbic Acid; Astrocytoma; Biopsy; Brain Chemistry; Brain Ede | 1994 |
Neurochemical monitoring and on-line pH measurements using brain microdialysis in patients in intensive care.
Topics: Acid-Base Equilibrium; Adult; Ascorbic Acid; Blood Glucose; Blood-Brain Barrier; Brain Edema; Brain | 1994 |
Hyperuricaemia and medium-chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Blood Glucose; Brain Edema; Female; Humans; Hypogly | 1997 |
Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia.
Topics: Allopurinol; Animals; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dose-Response | 1991 |
[Pathological and biochemical studies of unilateral cold-induced brain edema in the rat].
Topics: Amino Acids; Animals; Body Water; Brain; Brain Edema; Catecholamines; Cold Temperature; In Vitro Tec | 1987 |
[Early diagnosis, prevention and basic pathology of EPH gestosis].
Topics: Brain Edema; Diet, Sodium-Restricted; Edema; Energy Intake; Female; Humans; Hypertension; Pre-Eclamp | 1985 |