uric acid has been researched along with Brain Damage, Chronic in 6 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 5.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 1.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Romanos, E | 1 |
| Planas, AM | 1 |
| Amaro, S | 1 |
| Chamorro, A | 1 |
| Harkness, RA | 1 |
| Lund, RJ | 1 |
| Dorrepaal, CA | 1 |
| Berger, HM | 1 |
| Benders, MJ | 1 |
| van Zoeren-Grobben, D | 1 |
| Van de Bor, M | 1 |
| Van Bel, F | 1 |
| McKeran, RO | 1 |
| Howell, A | 1 |
| Andrews, TM | 1 |
| Watts, RW | 1 |
| Arlett, CF | 1 |
| Coleman, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset[NCT00860366] | Phase 2/Phase 3 | 421 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for uric acid and Brain Damage, Chronic
| Article | Year |
|---|---|
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Humans; Infarction, Middle Cerebral Artery; Male; Neuro | 2007 |
Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and inosine: high concentrations of the ATP metabolite, hypoxanthine, after hypoxia.
Topics: Adult; Asphyxia Neonatorum; Brain Damage, Chronic; Female; Fetal Hypoxia; Humans; Hypoxanthines; Inf | 1983 |
Nonprotein-bound iron in postasphyxial reperfusion injury of the newborn.
Topics: Asphyxia Neonatorum; Brain Damage, Chronic; Creatinine; Humans; Infant, Newborn; Iron; Lipid Peroxid | 1996 |
Observations on the growth in vitro of myeloid progenitor cells and fibroblasts from hemizygotes and heterozygotes for "complete" and "partial" hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency, and their relevance to the pathogenesis of b
Topics: Adult; Bone Marrow; Bone Marrow Cells; Brain; Brain Damage, Chronic; Cell Differentiation; Cell Divi | 1974 |
Reversal of organic brain syndrome with seizures and hyperuricosuria subsequent to allopurinol therapy.
Topics: Allopurinol; Brain Damage, Chronic; Child; Electroencephalography; Humans; Male; Purine-Pyrimidine M | 1971 |
Childhood hyperuricemia with brain disorder.
Topics: Athetosis; Brain Damage, Chronic; Child; Child, Preschool; Humans; Infant; Intellectual Disability; | 1965 |