Page last updated: 2024-10-20

uric acid and Bone Loss, Perimenopausal

uric acid has been researched along with Bone Loss, Perimenopausal in 12 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
"Although the positive correlation between serum uric acid (UA) levels and bone mineral density (BMD) has been reported in the general population, there are little data regarding the effect of serum UA levels on bone loss in patients with rheumatoid arthritis (RA)."7.96Higher serum uric acid levels are associated with reduced risk of hip osteoporosis in postmenopausal women with rheumatoid arthritis. ( Kim, A; Kim, GT; Kim, Y; Lee, HN; Lee, SG; Sohn, DH, 2020)
"Although the positive correlation between serum uric acid (UA) levels and bone mineral density (BMD) has been reported in the general population, there are little data regarding the effect of serum UA levels on bone loss in patients with rheumatoid arthritis (RA)."3.96Higher serum uric acid levels are associated with reduced risk of hip osteoporosis in postmenopausal women with rheumatoid arthritis. ( Kim, A; Kim, GT; Kim, Y; Lee, HN; Lee, SG; Sohn, DH, 2020)
"When calcium citrate was combined with potassium citrate, urinary calcium remained high, urinary citrate increased even further and urinary oxalate remained reduced from the calcium citrate alone, thereby marginally decreasing the urinary saturation of calcium oxalate."2.71Stone forming risk of calcium citrate supplementation in healthy postmenopausal women. ( Griffith, CS; Pak, CY; Poindexter, JR; Sakhaee, K, 2004)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (33.33)29.6817
2010's5 (41.67)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Lee, HN1
Kim, A1
Kim, Y1
Kim, GT1
Sohn, DH1
Lee, SG1
Zhao, X1
Yu, X1
Zhang, X1
Han, W2
Bai, X2
Han, L2
Sun, X2
Chen, X2
Wang, N1
Yan, DD1
Wang, J2
Hou, XH1
Bao, YQ1
Zhang, ZL1
Hu, C1
Jia, WP1
Ishii, S1
Miyao, M1
Mizuno, Y1
Tanaka-Ishikawa, M1
Akishita, M1
Ouchi, Y1
Dalbeth, N1
Gamble, GD1
Horne, A1
Reid, IR1
Pirro, M1
Mannarino, MR1
Bianconi, V1
De Vuono, S1
Sahebkar, A1
Bagaglia, F1
Franceschini, L1
Scarponi, AM1
Mannarino, E1
Merriman, T1
Black, DM1
Greenspan, SL1
Ensrud, KE1
Palermo, L1
McGowan, JA1
Lang, TF1
Garnero, P1
Bouxsein, ML1
Bilezikian, JP1
Rosen, CJ1
Sakhaee, K1
Poindexter, JR1
Griffith, CS1
Pak, CY1
Deal, C1
Omizo, M1
Schwartz, EN1
Eriksen, EF1
Cantor, P1
Glass, EV1
Myers, SL1
Krege, JH1
Yanik, B1
Bavbek, N1
Yanik, T1
Inegöl, I1
Kanbay, M1
Turgut, FH1
Uz, E1
Akçay, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Trial of Parathyroid Hormone (PTH) and Alendronate in Combination in the Treatment of Osteoporosis[NCT00005005]Phase 2238 participants (Actual)Interventional1999-10-31Completed
The Denosumab And Teriparatide Administration Study (DATA)[NCT00926380]Phase 294 participants (Actual)Interventional2009-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Spine Bone Density From Baseline to 2 Years

(NCT00926380)
Timeframe: Baseline and 2 years

Interventionpercent change (Mean)
Denosumab ONLY8.3
Teriparatide (Forteo®) ONLY9.5
Denosumab and Teriparatide (Forteo®)12.9

Trials

5 trials available for uric acid and Bone Loss, Perimenopausal

ArticleYear
Relationship Between Changes in Serum Urate and Bone Mineral Density During Treatment with Thiazide Diuretics: Secondary Analysis from a Randomized Controlled Trial.
    Calcified tissue international, 2016, Volume: 98, Issue:5

    Topics: Aged; Bone Density; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Middle Aged; Osteoporo

2016
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis.
    The New England journal of medicine, 2003, Sep-25, Volume: 349, Issue:13

    Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Alendronate; Biomarkers; Bone Density; Bone Remodel

2003
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis.
    The New England journal of medicine, 2003, Sep-25, Volume: 349, Issue:13

    Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Alendronate; Biomarkers; Bone Density; Bone Remodel

2003
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis.
    The New England journal of medicine, 2003, Sep-25, Volume: 349, Issue:13

    Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Alendronate; Biomarkers; Bone Density; Bone Remodel

2003
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis.
    The New England journal of medicine, 2003, Sep-25, Volume: 349, Issue:13

    Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Alendronate; Biomarkers; Bone Density; Bone Remodel

2003
Stone forming risk of calcium citrate supplementation in healthy postmenopausal women.
    The Journal of urology, 2004, Volume: 172, Issue:3

    Topics: Aged; Calcium; Calcium Citrate; Calcium Phosphates; Citric Acid; Dietary Supplements; Drug Therapy,

2004
Combination teriparatide and raloxifene therapy for postmenopausal osteoporosis: results from a 6-month double-blind placebo-controlled trial.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2005, Volume: 20, Issue:11

    Topics: Aged; Aged, 80 and over; Bone Density; Calcium; Collagen; Collagen Type I; Creatine; Double-Blind Me

2005
The effect of alendronate, risedronate, and raloxifene on renal functions, based on the Cockcroft and Gault method, in postmenopausal women.
    Renal failure, 2007, Volume: 29, Issue:4

    Topics: Aged; Alendronate; Bone Density Conservation Agents; C-Reactive Protein; Calcium; Etidronic Acid; Fe

2007

Other Studies

7 other studies available for uric acid and Bone Loss, Perimenopausal

ArticleYear
Higher serum uric acid levels are associated with reduced risk of hip osteoporosis in postmenopausal women with rheumatoid arthritis.
    Medicine, 2020, Jun-12, Volume: 99, Issue:24

    Topics: Aged; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Middle Aged; Osteoporosis, Pos

2020
Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study.
    Journal of diabetes research, 2020, Volume: 2020

    Topics: Age Factors; Aged; Aged, 80 and over; Body Mass Index; Bone Density; China; Cross-Sectional Studies;

2020
Association between higher serum uric acid levels within the normal physiological range and changes of lumbar spine bone mineral density in healthy Chinese postmenopausal women: a longitudinal follow-up study.
    Menopause (New York, N.Y.), 2021, 08-02, Volume: 28, Issue:10

    Topics: Absorptiometry, Photon; Bone Density; China; Female; Follow-Up Studies; Humans; Longitudinal Studies

2021
Association between lumbar bone mineral density and serum uric acid in postmenopausal women: a cross-sectional study of healthy Chinese population.
    Archives of osteoporosis, 2017, Volume: 12, Issue:1

    Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Body Mass Index; Bone Density; Bone Diseases, Metab

2017
Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population.
    Acta pharmacologica Sinica, 2018, Volume: 39, Issue:4

    Topics: Aged; Asian People; Biomarkers; Bone Remodeling; China; Collagen Type I; Female; Humans; Male; Middl

2018
Association between serum uric acid and lumbar spine bone mineral density in peri- and postmenopausal Japanese women.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014, Volume: 25, Issue:3

    Topics: Aged; Aging; Bone Density; Female; Humans; Lumbar Vertebrae; Menopause; Middle Aged; Osteoporosis, P

2014
Uric acid and bone mineral density in postmenopausal osteoporotic women: the link lies within the fat.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017, Volume: 28, Issue:3

    Topics: Adiposity; Aged; Aged, 80 and over; Alkaline Phosphatase; Anthropometry; Biomarkers; Bone and Bones;

2017