uric acid has been researched along with Bone Loss, Osteoclastic in 19 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether allopurinol dose escalation to achieve serum urate (SU) target can influence bone erosion or monosodium urate (MSU) crystal deposition, as measured by dual-energy computed tomography (DECT) in patients with gout." | 9.30 | Effects of Allopurinol Dose Escalation on Bone Erosion and Urate Volume in Gout: A Dual-Energy Computed Tomography Imaging Study Within a Randomized, Controlled Trial. ( Aati, O; Allan, J; Billington, K; Dalbeth, N; Doyle, A; Drake, J; Frampton, C; Horne, A; Stamp, LK; Tan, P, 2019) |
| "To examine whether allopurinol dose escalation to achieve serum urate (SU) target can influence bone erosion or monosodium urate (MSU) crystal deposition, as measured by dual-energy computed tomography (DECT) in patients with gout." | 5.30 | Effects of Allopurinol Dose Escalation on Bone Erosion and Urate Volume in Gout: A Dual-Energy Computed Tomography Imaging Study Within a Randomized, Controlled Trial. ( Aati, O; Allan, J; Billington, K; Dalbeth, N; Doyle, A; Drake, J; Frampton, C; Horne, A; Stamp, LK; Tan, P, 2019) |
| "Osteoporosis is a common bone metabolic disease in postmenopausal women, diabetic patients and obese patients and is characterized by an imbalance in bone formation and resorption." | 2.82 | Purine metabolism in the development of osteoporosis. ( Li, J; Tao, L; Yang, K, 2022) |
| "Idiopathic hypercalciuria is one of the most important risk factor of calcium nephrolithiasis and is classified into absorptive, resorptive, and renal leak." | 2.47 | [Renal calcium excretion and urolithiasis]. ( Aruga, S; Honma, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, K | 1 |
| Li, J | 1 |
| Tao, L | 1 |
| Sakaguchi, S | 1 |
| Dalbeth, N | 7 |
| Pool, B | 3 |
| Chhana, A | 3 |
| Lin, JM | 1 |
| Tay, ML | 2 |
| Tan, P | 2 |
| Callon, KE | 3 |
| Naot, D | 4 |
| Horne, A | 3 |
| Drake, J | 2 |
| Gamble, GD | 3 |
| Reid, IR | 2 |
| Grey, A | 1 |
| Stamp, LK | 2 |
| Cornish, J | 4 |
| Musson, D | 1 |
| McCarthy, G | 1 |
| McGlashan, S | 1 |
| Billington, K | 1 |
| Doyle, A | 1 |
| Frampton, C | 1 |
| Aati, O | 2 |
| Allan, J | 1 |
| Wu, ZQ | 1 |
| Zhang, Y | 1 |
| Xie, E | 1 |
| Song, WJ | 1 |
| Yang, RX | 1 |
| Yan, CJ | 1 |
| Zhang, BF | 1 |
| Xu, HG | 1 |
| Sapsford, M | 1 |
| Knight, J | 1 |
| Doyle, AJ | 1 |
| Smith, T | 1 |
| Nicolson, B | 1 |
| Clark, B | 1 |
| Callon, K | 1 |
| Haskard, DO | 1 |
| McQueen, FM | 2 |
| Merriman, T | 1 |
| Allaeys, I | 1 |
| Rusu, D | 1 |
| Picard, S | 1 |
| Pouliot, M | 1 |
| Borgeat, P | 1 |
| Poubelle, PE | 1 |
| Yoshihara, A | 1 |
| Hayashi, Y | 1 |
| Miyazaki, H | 1 |
| Watson, M | 1 |
| Aruga, S | 1 |
| Honma, Y | 1 |
| Rico Lenza, H | 1 |
| Huertas García-Alejo, R | 1 |
| Peh, CA | 1 |
| Horowitz, M | 1 |
| Wishart, JM | 1 |
| Need, AG | 1 |
| Morris, HA | 1 |
| Nordin, BE | 1 |
| Alwan, WH | 1 |
| Dieppe, PA | 1 |
| Elson, CJ | 1 |
| Bradfield, JW | 1 |
| Goldwasser, B | 1 |
| Weinerth, JL | 1 |
| Carson, CC | 1 |
| Greul, W | 1 |
| Lozano-Tonkin, C | 1 |
| Quagliata, F | 1 |
| Sanders, PM | 1 |
| Gardner, DL | 1 |
5 reviews available for uric acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Purine metabolism in the development of osteoporosis.
Topics: Bone Resorption; Female; Humans; Osteoclasts; Osteoporosis; Reactive Oxygen Species; Uric Acid | 2022 |
Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout.
Topics: Bone Resorption; Crystallization; Glucose Transport Proteins, Facilitative; Gout; Gout Suppressants; | 2009 |
[Renal calcium excretion and urolithiasis].
Topics: Adenylyl Cyclases; Bone Resorption; Calcium; Citric Acid; Dietary Proteins; Humans; Hypercalciuria; | 2011 |
[Calcitonin: a hormone with multisystemic effects].
Topics: Age Factors; Amino Acid Sequence; Amino Acids; Animals; Bone Resorption; Calcitonin; Calcium; Cyclic | 1981 |
Calcium stone disease: an overview.
Topics: Benzothiadiazines; Bone Resorption; Calcium; Calcium Oxalate; Calcium Phosphates; Calcium, Dietary; | 1986 |
2 trials available for uric acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Effects of Allopurinol Dose Escalation on Bone Erosion and Urate Volume in Gout: A Dual-Energy Computed Tomography Imaging Study Within a Randomized, Controlled Trial.
Topics: Aged; Allopurinol; Bone Resorption; Dose-Response Relationship, Drug; Female; Foot Bones; Foot Joint | 2019 |
The effect of chlorothiazide on bone-related biochemical variables in normal post-menopausal women.
Topics: Acid-Base Equilibrium; Aged; Biomarkers; Body Weight; Bone Resorption; Calcium; Chlorothiazide; Crea | 1993 |
12 other studies available for uric acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Repair of Bone Erosion With Effective Urate-Lowering Therapy in a Patient With Tophaceous Gout.
Topics: Benzbromarone; Bone Resorption; Enzyme Inhibitors; Gout; Humans; Male; Metatarsal Bones; Metatarsoph | 2021 |
Lack of Evidence that Soluble Urate Directly Influences Bone Remodelling: A Laboratory and Clinical Study.
Topics: Bone and Bones; Bone Remodeling; Bone Resorption; Cell Differentiation; Humans; Osteoclasts; Osteocy | 2018 |
Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state.
Topics: Animals; Bone Resorption; Cell Survival; Gout; Humans; Inflammation Mediators; Male; Mice; Mice, Inb | 2018 |
High Uric Acid (UA) Negatively Affects Serum Tartrate-Resistant Acid Phosphatase 5b (TRACP 5b) Immunoassay.
Topics: Acid Phosphatase; Adolescent; Adult; Aged; Biomarkers, Tumor; Bone Neoplasms; Bone Resorption; Case- | 2016 |
Relationship of bone erosion with the urate and soft tissue components of the tophus in gout: a dual energy computed tomography study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone Resorption; Female; Foot Joints; Gout; Humans; Line | 2017 |
Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells.
Topics: Acid Phosphatase; Animals; Bone Resorption; Cell Differentiation; Cell Line; Cohort Studies; Fibrobl | 2008 |
Osteoblast retraction induced by adherent neutrophils promotes osteoclast bone resorption: implication for altered bone remodeling in chronic gout.
Topics: Analysis of Variance; Bone Remodeling; Bone Resorption; Cell Adhesion; Flow Cytometry; Gout; Humans; | 2011 |
Relationships among bone turnover, renal function and periodontal disease in elderly Japanese.
Topics: Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Blood Urea Nitrogen; Bone Remodeling; Bone Reso | 2011 |
Monosodium urate monohydrate crystals inhibit osteoblast viability and function: implications for development of bone erosion in gout.
Topics: Animals; Apoptosis; Bone and Bones; Bone Resorption; Cell Death; Cell Differentiation; Cell Survival | 2011 |
Hydroxyapatite and urate crystal induced cytokine release by macrophages.
Topics: Animals; Bone Resorption; Cell Division; Cells, Cultured; Crystallization; Durapatite; Hydroxyapatit | 1989 |
[Hypercalcaemic crisis as primary manifestation of acute leukaemia in an adult (author's transl)].
Topics: Blood Cell Count; Blood Urea Nitrogen; Bone Marrow Examination; Bone Resorption; Creatinine; Cycloph | 1974 |
Inhibition of rat adjuvant arthritis by a new immunosuppressive agent rubidomycin.
Topics: Animals; Antibiotics, Antineoplastic; Arthritis; Bone Resorption; Cellulitis; Freund's Adjuvant; Imm | 1968 |