uric acid and Body Weight studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
" Compared with the placebo group, the empagliflozin group showed significant decreases in body weight, systolic blood pressure, and uric acid."	9.34	Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus: the EMBODY trial. ( Asai, K; Hoshika, Y; Ishikawa, M; Iwasaki, YK; Kodani, E; Kubota, Y; Maruyama, M; Miyamoto, M; Miyauchi, Y; Mozawa, K; Ogano, M; Shimizu, W; Takano, H; Tanabe, J; Tara, S; Tokita, Y; Tsukada, Y; Yamamoto, T; Yodogawa, K, 2020)
" All patients underwent at entry a physical examination, measurement of body weight (BW), blood pressure (BP), heart rate (HR), evaluation of signs of CHF, and controls of serum Na, K, Cl, bicarbonate, albumin, uric acid, creatinine, urea and glycemia and daily during hospitalization, as well as the daily output of urine for, Na, K and Cl measurements."	9.09	Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. ( Amato, P; Cardinale, A; Di Pasquale, P; Follone, G; Giubilato, A; Licata, G; Parrinello, G; Paterna, S, 2000)
"The pharmacodynamics of torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea), a new potent loop diuretic, were compared to those of furosemide in a double-blind controlled study in 18 patients with oedema of various origin."	9.06	Comparative pharmacodynamics of torasemide and furosemide in patients with oedema. ( Broekhuysen, J; Deger, F; Douchamps, J; Ducarne, H; Herchuelz, A, 1988)
"One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12."	9.06	Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986)
" A double-blind comparison of the effect of tienylic acid and hydrochlorothiazide on blood pressure was made in patients with moderate hypertension."	9.04	A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension. ( Gillies, AH; Morgan, TO, 1978)
"75 percent ethylene glycol (v/v) in their drinking water for six weeks to induce hyperoxaluria."	8.31	The preventive effects of Ulva lactuca aqueous extract, ulvan polysaccharides and atorvastatin on ethylene glycol-induced hyperoxaluria. ( Abdel-Gabbar, M; Abdelaziz, MA; Abdelzaher, MH; Ahmed, OM; Geddawy, AI; Ibrahim, SR; Moawd, SA; Mohammad, MR; Mohideen, AP, 2023)
"Despite the promising neuroprotective effects of uric acid (UA) in acute ischemic stroke, the seemingly pleiotropic underlying mechanisms are not completely understood."	8.02	Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke. ( Aliena-Valero, A; Baixauli-Martín, J; Chamorro, Á; Pérez, S; Rius-Pérez, S; Salom, JB; Torregrosa, G, 2021)
" Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight."	8.02	Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice. ( Akari, S; Katoh, N; Mizukami, H; Murase, T; Nakamura, T; Nampei, M; Satoh, E, 2021)
" The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)."	8.02	Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021)
"To compare the distribution of uric acid (UA) concentration in women with normal and preeclamptic pregnancy, to investigate the significance of UA concentration in diagnosis of preeclampsia, and to estimate the UA rate of change over time before delivery."	7.96	Investigating the diagnostic capacity of uric acid in the occurrence of preeclampsia. ( Pasyar, S; Peng, YP; Pudwell, J; Smith, GN; Wilson, LM, 2020)
"This study aimed to investigate effects of curcumin on high fructose diet (HFD)-induced metabolic syndrome (MetS) in rats and the possible mechanisms involved."	7.85	Curcumin improves the metabolic syndrome in high-fructose-diet-fed rats: role of TNF-α, NF-κB, and oxidative stress. ( Hakami, TM; Kelany, ME; Omar, AH, 2017)
"To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity."	7.81	[The role of uric acid in the insulin resistance in children and adolescents with obesity]. ( Almeida, GG; Belo, VA; Cunha, MB; de Miranda, JA; dos Santos, JE; Lanna, CM; Martins, RI; Mourão-Júnior, CA, 2015)
" Fructose administration resulted in significant increase in body weight, elevations of blood glucose, serum insulin, cholesterol, triglycerides, advanced glycation end products (AGEs), uric acid levels, insulin resistance index and blood pressure compared to control rats."	7.80	Ursodeoxycholic acid ameliorates fructose-induced metabolic syndrome in rats. ( Elshazly, SM; Mahmoud, AA, 2014)
"In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats."	7.78	Melatonin improves metabolic syndrome induced by high fructose intake in rats. ( Kitagawa, A; Ohashi, K; Ohta, Y, 2012)
" At the end of the feeding schedule, Dia group had insulin resistance along with increased blood glucose, triglyceride, uric acid and nitric oxide (NO) levels."	7.78	Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. ( Bagul, PK; Banerjee, SK; Bastia, T; Chakravarty, S; Madhusudana, K; Matapally, S; Middela, H; Padiya, R; Reddy, BR, 2012)
"To investigate if increased lipid peroxidation is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions."	7.73	Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats. ( Atarashi, K; Ishiyama, A; Minami, M; Omata, M; Takagi, M, 2005)
"Apocynin but not allopurinol prevented and reversed ACTH-induced hypertension in the rat."	7.73	Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat. ( Andrews, MC; Chan, MM; Croft, KD; McKenzie, KU; Mori, TA; Schyvens, CG; Whitworth, JA; Zhang, Y, 2005)
"Body weight and BP decreased significantly in the diet group but not in the troglitazone group at the end of the intervention periods."	7.71	Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. ( Kamide, K; Kawano, Y; Minami, J; Tsunoda, S, 2002)
" The aim of this study was to analyse the role of different variables of metabolic syndrome, including leptin, in 74 non-obese children and 68 children with non-syndromal obesity."	7.71	Leptin and metabolic syndrome in obese and non-obese children. ( Bueno, M; Fleta, J; Giner, A; Juste, MG; Moreno, LA; Pineda, I; Rodríguez, G; Sarría, A, 2002)
" Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, plasma glucose, body weight and chemiluminescence monitored oxidative stress in broiler chickens."	7.71	Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. ( Iqbal, M; Klandorf, H; Rathore, DS; Shi, X; Van Dyke, K, 2001)
"Survey of the serum lipoprotein profile, uric acid levels and body weight in Chinese patients with spinal cord injury (SCI) one year after injury, and to report the data of patients with SCI at different levels."	7.71	Body weight, serum uric acid and lipid profile one year after spinal cord injury. ( Chu, NK; Tang, FT; Wang, YC; Wong, MK; Wong, PY, 2001)
"Influence of dietary habits, body weight on blood uric acid was studied in 416 elderly people."	7.70	[Influence of dietary habits and body weight on blood uric acid in the elderly]. ( Tang, D; Xia, B, 1998)
"The relationship between elevated serum uric acid (SUA) and coronary heart disease (CHD) is discussed controversially."	7.68	Association of elevated serum uric acid with coronary heart disease in diabetes mellitus. ( Dannehl, K; Gries, FA; Hauner, H; Rathmann, W, 1993)
"Changes in serum lipids, apolipoproteins, and lipoproteins including high-density lipoprotein (HDL) subfractions following administration of captopril in patients with hypertension were studied."	7.67	Effect of captopril on high-density lipoprotein subfractions in patients with mild to moderate essential hypertension. ( Arakawa, K; Sasaki, J, 1989)
"Intrarenal handling of uric acid was studied in 12 patients with essential hypertension under spironolactone treatment (200 mg/day)."	7.66	Changes in intrarenal uric acid handling during chronic spironolactone treatment in patients with essential hypertension. ( Boer, P; Dorhout Mees, EJ; Peuker, KH; Roos, JC, 1982)
"Male and female, Sprague-Dawley rats, with and without arteriosclerosis, were subjected to chronic treatment with furosemide for 4 weeks."	7.66	Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats. ( Wexler, BC, 1981)
"The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension."	7.66	A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980)
"Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension."	7.66	Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study. ( Helgeland, A; Hjermann, I; Holme, I; Leren, P, 1978)
"Clinical assessment of dehydration in children with acute gastroenteritis (AGE) is crucial for treatment."	6.84	Uric acid and dehydration in children with gastroenteritis. ( Hasegawa, Y; Kuge, R; Morikawa, Y, 2017)
"A total of 422 patients with type 2 diabetes who were hypertensive [sitting systolic blood pressure (SBP) > or = 140 mmHg and/or diastolic blood pressure (DBP) > or = 90 mmHg] and microalbuminuric [urinary albumin excretion (UAE) 30-300 mg/day] were eligible for the study."	6.70	Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics. ( Aznar, J; Llisterri, JL; Lozano, JV; Redon, J, 2001)
"Bendroflumethiazide 5 mg was given to 17 patients with essential hypertension who had persistent mild to moderate hypertension despite treatment with nifedipine slow-release tablets 20 mg bid."	6.66	The effects of bendroflumethiazide added to nifedipine in patients with hypertension. ( Beevers, DG; Gill, JS; Zezulka, AV, 1987)
" Compared with baseline, all 3-month treatments significantly reduce body weight and subcutaneous fat area, but only TRE and combination treatment reduce visceral fat area (VFA), fasting blood glucose, uric acid (UA), and dyslipidemia."	5.51	Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial. ( Chen, H; Chen, Z; Deji, C; Geng, H; Guo, H; Guo, X; He, M; Hui, CC; Li, M; Liang, Q; Liu, Y; Ma, M; Qian, B; Rensen, PCN; Shi, B; Su, S; Sui, J; Wang, J; Wang, Y; Wang, YW; Zhang, M; Zheng, Y; Zhou, WX; Zhu, WZ, 2022)
" Compared with the placebo group, the empagliflozin group showed significant decreases in body weight, systolic blood pressure, and uric acid."	5.34	Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus: the EMBODY trial. ( Asai, K; Hoshika, Y; Ishikawa, M; Iwasaki, YK; Kodani, E; Kubota, Y; Maruyama, M; Miyamoto, M; Miyauchi, Y; Mozawa, K; Ogano, M; Shimizu, W; Takano, H; Tanabe, J; Tara, S; Tokita, Y; Tsukada, Y; Yamamoto, T; Yodogawa, K, 2020)
" SGLT2 inhibitors ameliorate cardiovascular morbidity and mortality as well as kidney disease progression by reducing body weight (BW), blood pressure (BP), visceral adiposity, albuminuria, and serum uric acid and blood glucose levels."	5.34	Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients. ( Aoki, T; Fujikura, T; Hashimoto, T; Ishigaki, S; Isobe, S; Kato, A; Matsuyama, T; Morita, H; Ohashi, N; Tsuriya, D; Yasuda, H, 2020)
"Celecoxib was administered i."	5.31	Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. ( Blumenthal, RD; Burton, J; Flefleh, C; Goldenberg, DM; Lew, W; Waskewich, C, 2001)
"Uric acid, which is an endogenous antioxidant was statistically significantly decreased in the urine and plasma of SDZ ICT 322 VE/SeD treated rats."	5.30	Enhancement of SDZ ICT 322-induced cataracts and skin changes in rats following vitamin E- and selenium-deficient diet. ( Cordier, A; Längle, UW; Wolf, A, 1997)
" Additional endpoints included other hemodynamic measures, serum uric acid, fasting plasma glucose, body weight, blood lipids and heart rate."	5.22	Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade. ( Alessi, F; Iqbal, N; Mansfield, TA; Parikh, S; Ptaszynska, A; Weber, MA, 2016)
" No significant changes were observed in fasting plasma glucose, quantitative insulin sensitivity check index, hs-CRP, superoxide dismutase, catalase and uric acid in the RS2 group as compared with the control group."	5.22	The Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial. ( Dehghan, P; Farhangi, MA; Gargari, BP; Karimi, P; Pouraghaei, M; Sarmadi, B; Zare Javid, A, 2016)
"Tolvaptan exerts diuretic effects and causes body weight loss at the low dose of 7."	5.15	Phase III clinical pharmacology study of tolvaptan. ( Hirayama, A; Hori, M; Inomata, T; Izumi, T; Matsuzaki, M, 2011)
"Uric acid is a strong scavenger of reactive oxygen species, which are known to contribute to the development of atherosclerosis, while the incidence of atherosclerotic diseases is rather high in patients with gout."	5.11	Oxidized low-density lipoprotein autoantibodies in patients with primary gout: effect of urate-lowering therapy. ( Ka, T; Moriwaki, Y; Takahashi, S; Tsutsumi, Z; Yamamoto, T, 2004)
" All patients underwent at entry a physical examination, measurement of body weight (BW), blood pressure (BP), heart rate (HR), evaluation of signs of CHF, and controls of serum Na, K, Cl, bicarbonate, albumin, uric acid, creatinine, urea and glycemia and daily during hospitalization, as well as the daily output of urine for, Na, K and Cl measurements."	5.09	Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. ( Amato, P; Cardinale, A; Di Pasquale, P; Follone, G; Giubilato, A; Licata, G; Parrinello, G; Paterna, S, 2000)
"The pharmacodynamics of torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea), a new potent loop diuretic, were compared to those of furosemide in a double-blind controlled study in 18 patients with oedema of various origin."	5.06	Comparative pharmacodynamics of torasemide and furosemide in patients with oedema. ( Broekhuysen, J; Deger, F; Douchamps, J; Ducarne, H; Herchuelz, A, 1988)
"One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12."	5.06	Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. ( Aranda, J; Barra, P; Davidov, M; Ettinger, B; Gorwit, J; McBarron, F; Morledge, JH, 1986)
"The pharmacodynamic effects of torasemide, a new potent loop diuretic, were compared with those of furosemide in a double blind controlled study in 18 hypertensive patients with oedema of various origins."	5.06	Torasemide, a new potent diuretic. Double-blind comparison with furosemide. ( Broekhuysen, J; Deger, F; Douchamps, J; Ducarne, H; Herchuelz, A, 1986)
" No significant differences were found for blood pressure, heart rate, body weight or serum uric acid."	5.04	Comparison between metoprolol and propranolol as antihypertensive agents. A double-blind cross-over study. ( Bengtsson, C, 1976)
"This study was designed to compare the effectiveness of spironolactone, hydrochlorothiazide, and combined spironolactone-hydrochlorothiazide therapy in patients with low renin and those with normal renin essential hypertension."	5.04	Diuretic therapies in low renin and normal renin essential hypertension. ( Brooks, CS; Johnson, CA; Kotchen, JM; Kotchen, TA, 1977)
" A double-blind comparison of the effect of tienylic acid and hydrochlorothiazide on blood pressure was made in patients with moderate hypertension."	5.04	A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension. ( Gillies, AH; Morgan, TO, 1978)
"A crossover comparison of metoprolol and hydrochlorothiazide has been performed in 20 patients with mild hypertension."	5.04	Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents. ( Pedersen, OL, 1976)
" The indirect effects involve a reduction in insulin levels and resistance, uric acid concentration, body weight, and blood pressure."	4.98	The Anticipated Renoprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors. ( Ito, M; Tanaka, T, 2018)
" SGLT2 inhibitors can decrease blood pressure levels and serum uric acid levels and may also reduce the degree of diabetes-related albuminuria."	4.95	Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies. ( Elisaf, MS; Filippatos, TD; Tsimihodimos, V, 2017)
"75 percent ethylene glycol (v/v) in their drinking water for six weeks to induce hyperoxaluria."	4.31	The preventive effects of Ulva lactuca aqueous extract, ulvan polysaccharides and atorvastatin on ethylene glycol-induced hyperoxaluria. ( Abdel-Gabbar, M; Abdelaziz, MA; Abdelzaher, MH; Ahmed, OM; Geddawy, AI; Ibrahim, SR; Moawd, SA; Mohammad, MR; Mohideen, AP, 2023)
"<b>Background and Objective:</b> Hyperuricemia is a disease triggered by disorders of uric acid metabolism."	4.31	Potential of Leave and Fruit Ethanolic Extract of ( Adika, AR; Karyadi, B; Melani, NAA; Nursaadah, E; Parlindungan, D; Ruyani, A, 2023)
" Biochemical evaluation was carried out by assessment of body weights and by estimating renal function tests (plasma urea, plasma creatinine and plasma uric acid), tissue antioxidant enzymes (catalase, SOD) and MDA level."	4.02	Protective role of salicylic acid in gentamicin induced nephrotoxicity. ( Fatimah, SN; Usman, SM, 2021)
"Despite the promising neuroprotective effects of uric acid (UA) in acute ischemic stroke, the seemingly pleiotropic underlying mechanisms are not completely understood."	4.02	Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke. ( Aliena-Valero, A; Baixauli-Martín, J; Chamorro, Á; Pérez, S; Rius-Pérez, S; Salom, JB; Torregrosa, G, 2021)
" Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight."	4.02	Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice. ( Akari, S; Katoh, N; Mizukami, H; Murase, T; Nakamura, T; Nampei, M; Satoh, E, 2021)
" The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA)."	4.02	Resveratrol affects the expression of uric acid transporter by improving inflammation. ( Nie, Q; Song, G; Wang, C; Wang, X; Zhang, F; Zhang, X; Zhang, Z; Zhao, J, 2021)
" Their body weight, water and food consumption, 24-h urine and feces, uric acid in serum and organs, and serum indexes were recorded or assayed."	4.02	Uricase deficiency causes mild and multiple organ injuries in rats. ( Chen, H; Dong, X; Duan, W; Fan, N; Li, L; Li, Y; Xia, H; Yu, Y, 2021)
"To compare the distribution of uric acid (UA) concentration in women with normal and preeclamptic pregnancy, to investigate the significance of UA concentration in diagnosis of preeclampsia, and to estimate the UA rate of change over time before delivery."	3.96	Investigating the diagnostic capacity of uric acid in the occurrence of preeclampsia. ( Pasyar, S; Peng, YP; Pudwell, J; Smith, GN; Wilson, LM, 2020)
"Previously, we formulated a PK-PD model for predicting the hypouricaemic effects of febuxostat as a function of baseline serum urate levels, body weight, renal function and drug dose, using datasets reported in preapproval studies."	3.88	Evaluation of a pharmacokinetic-pharmacodynamic model for hypouricaemic effects of febuxostat using datasets obtained from real-world patients. ( Echizen, H; Hirai, T; Itoh, T; Kimura, T, 2018)
"After the training period, body weight, body fat percentage, body mass index and uric acid levels in serum decreased significantly (p < 0."	3.85	Effects of 6-week Nordic walking training on body composition and antioxidant status for women > 55 years of age. ( Cebula, A; Frączek, B; Pałka, T; Pilch, W; Sztafa-Cabała, K; Szyguła, Z; Tyka, A; Tyka, AK, 2017)
"This study aimed to investigate effects of curcumin on high fructose diet (HFD)-induced metabolic syndrome (MetS) in rats and the possible mechanisms involved."	3.85	Curcumin improves the metabolic syndrome in high-fructose-diet-fed rats: role of TNF-α, NF-κB, and oxidative stress. ( Hakami, TM; Kelany, ME; Omar, AH, 2017)
"To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity."	3.81	[The role of uric acid in the insulin resistance in children and adolescents with obesity]. ( Almeida, GG; Belo, VA; Cunha, MB; de Miranda, JA; dos Santos, JE; Lanna, CM; Martins, RI; Mourão-Júnior, CA, 2015)
"Over a 20-year period, patients on dapagliflozin were projected to experience relative reductions in the incidence of myocardial infarction (MI), stroke, CV death, and all-cause death of 13."	3.80	Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes. ( Alperin, P; Cohen, M; Dziuba, J; Goswami, D; Grossman, HL; Hardy, E; Iloeje, U; Perlstein, I; Racketa, J, 2014)
" Fructose administration resulted in significant increase in body weight, elevations of blood glucose, serum insulin, cholesterol, triglycerides, advanced glycation end products (AGEs), uric acid levels, insulin resistance index and blood pressure compared to control rats."	3.80	Ursodeoxycholic acid ameliorates fructose-induced metabolic syndrome in rats. ( Elshazly, SM; Mahmoud, AA, 2014)
" The feed intake, body weight, blood glucose, interleukin 2 (IL-2), interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-alpha), haematological parameters, serum lipid profile and uric acid, liver reduced glutathione and malodialdehyde were determined."	3.79	Immunomodulatory activities of Yoyo bitters: recommended dose precipitated inflammatory responses in male Wistar rats. ( Adebisi, JA; Adetutu, A; Oyewo, EB, 2013)
"In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats."	3.78	Melatonin improves metabolic syndrome induced by high fructose intake in rats. ( Kitagawa, A; Ohashi, K; Ohta, Y, 2012)
" At the end of the feeding schedule, Dia group had insulin resistance along with increased blood glucose, triglyceride, uric acid and nitric oxide (NO) levels."	3.78	Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. ( Bagul, PK; Banerjee, SK; Bastia, T; Chakravarty, S; Madhusudana, K; Matapally, S; Middela, H; Padiya, R; Reddy, BR, 2012)
"Maximum weight is a strong risk factor for increased uric acid level in the Chinese population, which might serve as a novel clinical indicator suggesting hyperuricemia."	3.78	Association of maximum weight with hyperuricemia risk: a retrospective study of 21,414 Chinese people. ( Chen, F; Fu, J; Gao, B; Ge, J; Ji, Q; Jia, H; Lau, WB; Li, X; Wan, Y; Wang, L; Xing, Y; Zhang, N; Zhang, Y; Zhao, X; Zhou, J, 2012)
" Blood pressure and uric acid was most strongly correlated with body weight and height (heavier and taller boys)."	3.77	Differential relationships between anthropometry measures and cardiovascular risk factors in boys and girls. ( Beilin, LJ; de Klerk, N; Hands, B; Huang, RC; Landau, LI; Mori, TA; Newnham, JP; Oddy, WH; Stanley, FJ, 2011)
"Serum uric acid (UA) is positively associated with hypertension (HTN)."	3.77	Serum uric acid is associated with high blood pressure in pediatric hemodialysis patients. ( Feig, DI; Goldstein, SL; Mattison, P; Midgley, L; Moudgil, A; Silverstein, DM; Srivaths, PR; Upadhyay, K, 2011)
" DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities as well as the level of nonenzymatic antioxidants--urea and uric acids, because during organism aging the antioxidant defense systems are being suppressed."	3.77	[Mechanism of delta-sleep inducing peptide geroprotective activity]. ( Bondarenko, TI; Maĭboroda, EA; Mikhaleva, II; Prudchenko, IA, 2011)
" Daily measurements of body weight, urine volume, and concentration of sodium, potassium and uric acid in urine were performed for each rat."	3.76	Diuretic and antioxidant effects of Cacti-Nea, a dehydrated water extract from prickly pear fruit, in rats. ( Bisson, JF; Daubié, S; Guillemet, D; Hidalgo, S; Linarés, E, 2010)
" We enrolled 777 healthy women and women with breast cancer in our nested case-control study to evaluate the association between MS and breast cancer, analyzing anthropometric parameters (weight, height, BMI, waist and hip circumference), blood pressure, serum HDL-C, triglyceride, fasting plasma glucose, insulin, testosterone and uric acid levels and administering a questionnaire about physical activity, food intake, tobacco use, alcohol abuse, personal and familial history of disease."	3.76	Metabolic syndrome affects breast cancer risk in postmenopausal women: National Cancer Institute of Naples experience. ( Capasso, I; Cavalcanti, E; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Marco, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Giordano, A; Grimaldi, M; Maurea, N; Montella, M; Pedicini, T; Pentimalli, F; Vecchione, A, 2010)
" At moderate or high doses, an effect on any one marker may be absent or even the opposite of that observed at very high or excessive doses; examples include fasting plasma triglyceride, insulin sensitivity, and the putative marker uric acid."	3.75	Fructose ingestion: dose-dependent responses in health research. ( Livesey, G, 2009)
" Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance."	3.74	Thiazide diuretics exacerbate fructose-induced metabolic syndrome. ( Johnson, RJ; Mu, W; Nakagawa, T; Reungjui, S; Roncal, CA; Sirivongs, D; Srinivas, TR, 2007)
"To investigate if increased lipid peroxidation is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions."	3.73	Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats. ( Atarashi, K; Ishiyama, A; Minami, M; Omata, M; Takagi, M, 2005)
"Apocynin but not allopurinol prevented and reversed ACTH-induced hypertension in the rat."	3.73	Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat. ( Andrews, MC; Chan, MM; Croft, KD; McKenzie, KU; Mori, TA; Schyvens, CG; Whitworth, JA; Zhang, Y, 2005)
" In STZ-diabetic group, blood glucose, serum sialic and uric acid levels, serum catalase (CAT) and lactate dehydrogenase (LDH) activities, brain lipid peroxidation (LPO) and nonenzymatic glycosylation (NEG) increased, while brain glutathione (GSH) level and body weight decreased."	3.73	Vanadyl sulfate administration protects the streptozotocin-induced oxidative damage to brain tissue in rats. ( Tunali, S; Yanardag, R, 2006)
"2-5 months-lingth ambulatory tested hypocaloric diet in patients mith obesity makes for normalization of lipid, hydrocarbon metabolism, as creatinine and uric acid in blood against the background of patients body weight reduction."	3.73	[The influence of ambulatory tested hypocaloric diet on biochemical indexes of patients of different ages suffering from obesity]. ( Gapparov, MM; Gavrik, MV, 2006)
"Body weight and BP decreased significantly in the diet group but not in the troglitazone group at the end of the intervention periods."	3.71	Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. ( Kamide, K; Kawano, Y; Minami, J; Tsunoda, S, 2002)
" The aim of this study was to analyse the role of different variables of metabolic syndrome, including leptin, in 74 non-obese children and 68 children with non-syndromal obesity."	3.71	Leptin and metabolic syndrome in obese and non-obese children. ( Bueno, M; Fleta, J; Giner, A; Juste, MG; Moreno, LA; Pineda, I; Rodríguez, G; Sarría, A, 2002)
" We investigated the effect of such a combination therapy, using the Ephedra herb, which is a common ingredient of Kakkon-to and Mao-to, and Loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID), on fever induced in an experimental model of mice under strong stress."	3.71	The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice. ( Aikawa, Y; Cho, S; Cyong, JC; Hong, T; Jin, GB; Miura, M; Yasuno, F; Yoshino, G, 2002)
"To study on effect of obesity on changes in serum hypoxanthine with exercise, exercise stress testing with treadmill was performed on 7 obese subjects (body mass index [BMI], 30."	3.71	Changes in serum hypoxanthine levels by exercise in obese subjects. ( Kamimoto, M; Kohzuki, M; Saiki, S; Sato, T; Yosida, T, 2001)
" Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, plasma glucose, body weight and chemiluminescence monitored oxidative stress in broiler chickens."	3.71	Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. ( Iqbal, M; Klandorf, H; Rathore, DS; Shi, X; Van Dyke, K, 2001)
"Survey of the serum lipoprotein profile, uric acid levels and body weight in Chinese patients with spinal cord injury (SCI) one year after injury, and to report the data of patients with SCI at different levels."	3.71	Body weight, serum uric acid and lipid profile one year after spinal cord injury. ( Chu, NK; Tang, FT; Wang, YC; Wong, MK; Wong, PY, 2001)
" The high prevalence and severity of metabolic disturbances associated with the insulin resistance syndrome (hyperglycaemia, hyperinsulinaemia, decreased HDL cholesterol, hypertriglyceridaemia, elevated fibrinogen levels and hyperuricaemia) before gastroplasty were significantly decreased after weight loss."	3.70	Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity. ( Desaive, C; Dewe, W; Gielen, JE; Lefebvre, PJ; Luyckx, FH; Scheen, AJ, 1998)
"Influence of dietary habits, body weight on blood uric acid was studied in 416 elderly people."	3.70	[Influence of dietary habits and body weight on blood uric acid in the elderly]. ( Tang, D; Xia, B, 1998)
"Behavioural and biological correlates of serum uric acid were investigated in 2487 men who received a retirement health examination at the Self-Defence Forces Fukuoka Hospital from October 1986 through 1990, excluding those under medication for hyperuricaemia, hypertension or hyperlipidaemia."	3.69	Behavioural and biological correlates of serum uric acid: a study of self-defence officials in Japan. ( Honjo, S; Imanishi, K; Kono, S; Shinchi, K; Todoroki, I, 1994)
" The NB diet provoked body weight and feeding efficiency enhancement with a reduction in body density increasing serum lactic acid, uric acid and cholesterol levels."	3.69	Dietary nitrite and scavenger antioxidants trace elements. ( de Angelis, RC; Klemps, I; Scialfa, JH; Terra, IC, 1996)
"The fractional excretion of lithium was inversely associated with body weight, body mass index, diastolic blood pressure, serum triglycerides level and serum uric acid level whereas it was positively associated with serum high-density lipoprotein cholesterol level."	3.69	Increased proximal sodium reabsorption is associated with increased cardiovascular risk in men. ( Cappuccio, FP; Siani, A; Strazzullo, P; Trevisan, M, 1996)
"The relationship between elevated serum uric acid (SUA) and coronary heart disease (CHD) is discussed controversially."	3.68	Association of elevated serum uric acid with coronary heart disease in diabetes mellitus. ( Dannehl, K; Gries, FA; Hauner, H; Rathmann, W, 1993)
"To assess the relationship between obesity and body fat distribution with cardiovascular risk factors in children, various measures of obesity and waist-to-hip circumference ratio (WHR) were related to serum lipids, lipoproteins, apolipoproteins, glucose, insulin, uric acid, systolic (SBP) and diastolic blood pressure (DBP)."	3.68	Cardiovascular risk factors in obese children in relation to weight and body fat distribution. ( Mueller, T; Pakosta, R; Widhalm, K; Zwiauer, KF, 1992)
" Body weights and efficiency of feed utilization were depressed and the activity of serum SDH and GDH and the concentration of uric acid were significantly increased."	3.68	Effect on ochratoxin A on Lohmann-type chicks. ( Adam, SE; Ayed, IA; Dafalla, R; Yagi, AI, 1991)
"In order to evaluate both the hypotensive and uric acid-retaining effects of thiazide diuretics in an animal model with hypertension, the effects of trichlormethiazide were studied using spontaneously hypertensive rats (SHR) under dietary sodium restriction."	3.67	Hypotensive and uric acid-retaining effects of trichlormethiazide under dietary sodium restriction in spontaneously hypertensive rats. ( Ishii, M; Iwaki, K; Yonetani, Y, 1984)
"Changes in serum lipids, apolipoproteins, and lipoproteins including high-density lipoprotein (HDL) subfractions following administration of captopril in patients with hypertension were studied."	3.67	Effect of captopril on high-density lipoprotein subfractions in patients with mild to moderate essential hypertension. ( Arakawa, K; Sasaki, J, 1989)
"The influence of a family history of hypertension on body mass index, serum lipids, uric acid, blood sugar and haematocrit was investigated in 579 young normotensives aged 19-35 years with or without a parental history of hypertension."	3.67	Clinical alterations in normotensive offspring with parental hypertension. ( Fujishima, M; Takishita, S; Tomita, Y; Tsuchihashi, T; Ueno, M, 1988)
"The relationship between body weight and blood pressure, total serum cholesterol, triglycerides, uric acid and glucose was investigated in 203 psoriatic patients in comparison with 904 healthy controls."	3.67	Relationship between body weight and blood pressure and some metabolic parameters in psoriatic patients. ( Ambrosio, GB; Bertoli, P; Cipriani, R; Fornasa, CV; Padovan, S; Pagnan, A; Peserico, A; Zamboni, S; Zanetti, G, 1988)
"Uric acid levels of adult male volunteers in a longitudinal study of human aging rose steadily between 1961 and 1978."	3.66	Trends in serum uric acid levels 1961--1980. ( Campion, EW; Glynn, RJ; Silbert, JE, 1983)
"Intrarenal handling of uric acid was studied in 12 patients with essential hypertension under spironolactone treatment (200 mg/day)."	3.66	Changes in intrarenal uric acid handling during chronic spironolactone treatment in patients with essential hypertension. ( Boer, P; Dorhout Mees, EJ; Peuker, KH; Roos, JC, 1982)
"Male and female, Sprague-Dawley rats, with and without arteriosclerosis, were subjected to chronic treatment with furosemide for 4 weeks."	3.66	Furosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic rats. ( Wexler, BC, 1981)
" Trials with four commercial strains of broiler chicks revealed strain differences with respect to the requirement when body weight gain, feed conversion, liver storage of the vitamin, and blood uric acid were used as indicators of vitamin A status."	3.66	Vitamin A requirement of broiler chicks in Nigeria. ( Ogunmodede, BK, 1981)
" In experiment 1, equal amounts of a PF or MA diet were given and body weight change, N excretion, N balance and uric acid N excretion were measured to serve as criteria in determining the nitrogen sparing action."	3.66	Influence of dietary energy on the nitrogen sparing action of methionine and arginine in chicks fed a protein-free diet. ( Muramatsu, T; Okumura, JI, 1980)
" Regression analysis revealed statistically significant changes of systolic and diastolic blood pressures, fasting blood glucose, serum cholesterol, serum triglycerides and serum uric acid with changes in body weight."	3.66	Body weight change in relation to incidence of ischemic heart disease and change in risk factors for ischemic heart disease. ( Noppa, H, 1980)
"The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension."	3.66	A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980)
" Criteria measured were body weight, feed efficiency, plasma urea nitrogen, serum uric acid, serum total protein, albumin, globulin and albumin-globulin ratios."	3.66	Blood constituents of yeast fed chicks. ( Daghir, NJ; Saoud, NB, 1980)
"Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension."	3.66	Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study. ( Helgeland, A; Hjermann, I; Holme, I; Leren, P, 1978)
" These changes include hydronephrosis, decreased BUN and uric acid, proteinuria and glycosuria (70 percent one time), frequency, nocturia, edema (80 percent) and reductions in blood pressure."	3.66	The kidney and pregnancy. ( Chester, AC; Harris, JP; Schreiner, GE, 1978)
"The relationship between the dosage of pancreatic extract and the excretion of uric acid was investigated in 29 patients with cystic fibrosis and exocrine pancreatic insufficiency."	3.65	Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. ( Kennedy, J; Linshaw, MA; Nouisa-Arvanitakis, S; Stapleton, FB, 1977)
"Plasma uric acid levels in 35 obese gouty and non-gouty subjects showed a highly significant mean fall of 0."	3.65	The effect of weight loss on plasma and urinary uric acid and lipid levels. ( Scott, JT; Sturge, RA, 1977)
" Data on blood pressure, obesity and serum lipids are presented here, and are discussed together with smoking and serum uric acid."	3.65	Coronary risk factors in New Zealand Maori and European adolescents: The Rotoua Lakes Study 2. ( Malcolm, JB; Stanhope, JM, 1975)
"The etiology of hyperuricemia following myocardial infarction was investigated by uric acid kinetic studies carried out on seven male patients following myocardial infarction and on two control subjects."	3.65	Uric acid kinetic studies in the immediate post-myocardial-infarction period. ( Crawhall, JC; Dosman, JA; Klassen, GA, 1975)
"Fourteen subjects with type 2 diabetes (aged 49·5 (sd 8·6) years, BMI 29·4 (sd 4·5) kg/m2, low habitual Ca consumption (<600 mg/d)) were included in this randomised, crossover clinical trial."	2.90	High calcium intake from fat-free milk, body composition and glycaemic control in adults with type 2 diabetes: a randomised crossover clinical trial. ( Alfenas, RCG; de Assis Costa, J; Gomes, JMG; Ribeiro, PVM, 2019)
"Clinical assessment of dehydration in children with acute gastroenteritis (AGE) is crucial for treatment."	2.84	Uric acid and dehydration in children with gastroenteritis. ( Hasegawa, Y; Kuge, R; Morikawa, Y, 2017)
" The dosing regimens to maintain uric acid levels below the therapeutic target of 6 mg/dL were then predicted by the model."	2.73	Population pharmacokinetic and pharmacodynamic analysis of pegloticase in subjects with hyperuricemia and treatment-failure gout. ( Alton, M; Huang, W; Marco, MD; Maroli, AN; Waltrip, RW; Wright, D; Yue, CS, 2008)
"A total of 422 patients with type 2 diabetes who were hypertensive [sitting systolic blood pressure (SBP) > or = 140 mmHg and/or diastolic blood pressure (DBP) > or = 90 mmHg] and microalbuminuric [urinary albumin excretion (UAE) 30-300 mg/day] were eligible for the study."	2.70	Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics. ( Aznar, J; Llisterri, JL; Lozano, JV; Redon, J, 2001)
"Bendroflumethiazide 5 mg was given to 17 patients with essential hypertension who had persistent mild to moderate hypertension despite treatment with nifedipine slow-release tablets 20 mg bid."	2.66	The effects of bendroflumethiazide added to nifedipine in patients with hypertension. ( Beevers, DG; Gill, JS; Zezulka, AV, 1987)
" Blood pressure was significantly reduced with both medications, although most patients required an increase in dosage from 250 to 500 mg ticrynafen daily."	2.64	Clinical study of ticrynafen. A new diuretic, antihypertensive, and uricosuric agent. ( Freis, ED; Kyle, MC; Nemati, M, 1977)
"Gout is one of the most prevalent inflammatory rheumatic disease."	2.61	Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review. ( de Vries, R; Gerritsen, M; Heslinga, M; Nurmohamed, M; van Schaardenburg, D; Vedder, D; Walrabenstein, W, 2019)
"Xipamide is a diuretic derived from salicylic acid and has a structural resemblance to chlorthalidone."	2.37	Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. ( Brogden, RN; Prichard, BN, 1985)
"Hyperuricemia has been recognized as a risk factor for insulin resistance as well as one of the factors leading to diabetic kidney disease (DKD)."	1.51	Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice. ( Asano, T; Fujishiro, M; Inoue, MK; Kikuchi, T; Kushiyama, A; Masaki, T; Matsunaga, Y; Mizuno, Y; Morii, K; Nakatsu, Y; Ono, H; Sakoda, H; Sasaki, K; Takahashi, M; Ueda, K; Yamamotoya, T, 2019)
"Indication-based, low-dose rasburicase displayed significantly more value when compared to weight-based dosing as shown by achieving cost savings without compromising clinical efficacy."	1.51	The value of fixed rasburicase dosing versus weight-based dosing in the treatment and prevention of tumor lysis syndrome. ( Blackman, A; Boutin, A; Forcello, N; O'Sullivan, DM, 2019)
" Therefore, this study deduces that alpha-tocopherol administration may ameliorate the adverse effects of subacute exposure to MT on rat liver and kidney and this antioxidant can protect PON1 from oxidative stress induced by this organophosphorus pesticide."	1.43	Toxic effects of methamidophos on paraoxonase 1 activity and on rat kidney and liver and ameliorating effects of alpha-tocopherol. ( Araoud, M; Douki, W; Houas, Z; Kenani, A; Khaled, L; Najjar, MF; Neffeti, F, 2016)
"Heavy metals are known to be toxic to organisms."	1.43	Nephrotoxic effects of lead nitrate exposure in diabetic and nondiabetic rats: Involvement of oxidative stress and the protective role of sodium selenite. ( Baş, H; Kalender, Y, 2016)
"Experimental diabetes mellitus was produced by a single intraperitoneal injection of STZ (55mg/kg b."	1.43	Antihyperglycemic and antidiabetic effects of Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate in streptozotocin-induced diabetic Wistar rats. ( Berredjem, H; Berredjem, M; Bouzerna, N; Cheloufi, H; Réggami, Y, 2016)
" According to ADME (absorption, distribution, metabolism, and excretion) simulation in silico, flazin had good oral bioavailability in vivo."	1.43	Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor. ( Li, H; Lin, L; Su, G; Wang, Y; Zhao, M, 2016)
" Both biochemical and morphological studies clearly revealed that chrysin protects against cell injury induced by ammonia intoxication in a dose-response manner with respect to endogenous antioxidants and hypoammonemic effects."	1.43	Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study. ( Ramakrishnan, A; Renuka, M; Vijayakumar, N, 2016)
"Overweight and obesity are becoming more and more relevant for armed forces in westernized countries, especially with respect to the impact on recruitment and soldiers' performance."	1.42	Results of a course based obesity intervention program during work. ( Sammito, S, 2015)
"To evaluate single fixed dosing versus weight-based dosing strategies for rasburicase to determine the minimum dose required to mitigate hyperuricemia in the treatment or prevention of tumor lysis syndrome."	1.39	Comparative evaluation of single fixed dosing and weight-based dosing of rasburicase for tumor lysis syndrome. ( Augustin, KM; Boehmer, L; Butler, SK; Lathon, SC; McBride, A; Westervelt, P, 2013)
"A perspective adsorptive method to minimize systemic toxic effects of chemotherapy is enterosorption (ES)."	1.39	Enterosorption as a method to decrease the systemic toxicity of cisplatin. ( Bardakhivskaya, KI; Ivanyuk, AA; Korotich, VG; Maslenniy, VN; Nikolaev, VG; Nikolaeva, VV; Sakhno, LA; Shevchuk, OO; Yurchenko, OV, 2013)
" These findings suggest that furocoumarins may interfere in metabolism, excretion and bioavailability of endogenous and exogenous compounds to impair liver and kidney functions mediated by affecting hepatic CYP450 and renal organic ion transport system."	1.38	Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice. ( Kong, LD; Lou, YJ; Shi, YW; Wang, MX; Wang, X; Xu, HX, 2012)
"Cachexia is a common co-morbidity in cancer occurring in up to 80% of patients depending on the type of cancer."	1.38	Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia. ( Adams, V; Anker, SD; Argiles, JM; Doehner, W; Hartman, K; Köhrle, J; Möller, N; Palus, S; Ruis, SB; Springer, J; Tschirner, A; von Haehling, S; Wirth, EK, 2012)
"The treatment of quercetin and allopurinol regulated renal urate transport-related proteins to reduce hyperuricemia, and lipid metabolism-related genes to alleviate kidney lipid accumulation in STZ-treated rats."	1.38	Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. ( Kong, LD; Pan, Y; Wang, C; Wang, FM; Zhang, QY, 2012)
"The development of obesity is determined by lifestyle and genetic mechanisms."	1.38	[The Trp64Arg polymorphism of beta3-adrenoreceptor gene study in persons with overweight and obesity]. ( Baturin, AK; Makurina, ON; Pogozheva, AV; Sorokina, EIu; Tutel'ian, VA, 2012)
"Effects of the dosing matrix and timing on the onset of renal crystal formation were evaluated in male and non-pregnant female rats (Fisher 344) exposed to both melamine (MEL) and cyanuric acid (CYA) for 28 days."	1.38	Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: gavage vs. feeding. ( Bandele, O; Black, T; Crosby, T; Evans, E; Ferguson, M; Gamboa da Costa, G; Keltner, Z; Loukotková, L; Nemser, SM; Olejnik, N; Reimschuessel, R; Scott, M; Sprando, RL; Stine, CB; Tkachenko, A; Woodling, K, 2012)
" Weaning rats (F0) were fed with NTs at the dosage of 0."	1.38	Multigenerations assessment of dietary nucleotides consumption in weaned rats. ( Li, Y; Ma, Y; Xu, L; Xu, M; Xu, Y, 2012)
"96 million (96%) direct cost savings for the 48 patients in this study when compared to the cost of manufacturer's dosing recommendation."	1.37	Evaluation of a low, weight-based dose of rasburicase in adult patients for the treatment or prophylaxis of tumor lysis syndrome. ( Crank, CW; Knoebel, RW; Lo, M, 2011)
" (no observed adverse effects level, NOAEL) and 1."	1.37	Adverse effects of exposure to low doses of chlorpyrifos in lactating rats. ( Mansour, SA; Mossa, AT, 2011)
"Metabolic syndrome was induced in rats over 8 wk by either a high-fructose diet (60%, F60, n = 7) or by adding fructose to drinking water (10%, F10, n = 7)."	1.34	Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. ( Avila-Casado, C; Bautista, P; Cristóbal, M; Franco, M; Herrera-Acosta, J; Jiménez, A; Johnson, RJ; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007)
"Glycerol levels were negatively related to the rate of mass change (independent of diet), and butyrate was negatively related to the rate of mass change on both diets (though the slope of this relationship was diet dependent)."	1.33	Effects of physiological state, mass change and diet on plasma metabolite profiles in the western sandpiper Calidris mauri. ( Guglielmo, CG; Seaman, DA; Williams, TD, 2005)
"Insulin resistance was measured by homeostasis model assessment (HOMA)."	1.33	Serum resistin level among healthy subjects: relationship to anthropometric and metabolic parameters. ( Chen, CC; Li, CI; Li, TC; Lin, CC; Liu, CS; Wang, HJ, 2005)
" However, long-term use of PTD to replace enzymes in animal models or patients has not previously been described."	1.33	TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. ( Grunebaum, E; Toro, A, 2006)
"Body weights were measured biweekly throughout the study, and blood samples were drawn from wk 8 to 10 for determination of PUA concentration, leukocyte oxidative activity (LOA), and differential leukocyte counts."	1.32	Fructose and its effect on turkey plasma uric acid levels and productive performance. ( Klandorf, H; Simoyi, MF, 2003)
"To investigate the impact of obstructive sleep apnea syndrome (OSAS) on testosterone levels and on the main parameters of the metabolic syndrome in abdominally obese men, 15 male subjects with abdominal obesity phenotype and polysomnographic diagnosis of OSAS (OB-OSAS) and 15 controls matched for age and anthropometric parameters (OB) were investigated."	1.32	Testosterone levels in obese male patients with obstructive sleep apnea syndrome: relation to oxygen desaturation, body weight, fat distribution and the metabolic parameters. ( Gambineri, A; Pasquali, R; Pelusi, C, 2003)
"Uric acid is an important antioxidant and methods to elevate its plasma concentration may be important in animal health."	1.32	Increased dietary protein elevates plasma uric acid and is associated with decreased oxidative stress in rapidly-growing broilers. ( Blemings, KP; Klandorf, H; Machín, M; Simoyi, MF, 2004)
" In Experiment 1, vitamin D3 was supplemented at a dosage of either 2,064 IU/kg (low level) or 4,128 IU/kg (high level) in drinking water provided ad libitum only from Days 1 through 5 after hatch."	1.31	The effect of vitamin D3 on resistance to stress-related infection in an experimental model of turkey osteomyelitis complex. ( Balog, JM; Huff, GR; Huff, WE; Rath, NC, 2000)
"Celecoxib was administered i."	1.31	Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. ( Blumenthal, RD; Burton, J; Flefleh, C; Goldenberg, DM; Lew, W; Waskewich, C, 2001)
"Uric acid, which is an endogenous antioxidant was statistically significantly decreased in the urine and plasma of SDZ ICT 322 VE/SeD treated rats."	1.30	Enhancement of SDZ ICT 322-induced cataracts and skin changes in rats following vitamin E- and selenium-deficient diet. ( Cordier, A; Längle, UW; Wolf, A, 1997)
"L-Carnitine treatment for 6 weeks lowered significantly both the systolic and mean arterial pressure of SHR but its influence on diastolic and pulse pressure was only modest."	1.30	The effect of chronic L-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats. ( Dobesová, Z; Drahota, Z; Kunes, J; Rauchová, H; Zicha, J, 1998)
"In conclusion, the data suggest that NIDDM, hypertension, tallness, obesity, high insulin and low HDL cholesterol levels constitute risk factors for the development of BPH."	1.30	Clinical, anthropometric, metabolic and insulin profile of men with fast annual growth rates of benign prostatic hyperplasia. ( Hammarsten, J; Högstedt, B, 1999)
" Female turkeys, 8 weeks of age, were dually cannulated via the right jugular for intermittent (10 min every 2 hr) infusion of tGH at a low dosage (4."	1.29	Responses to exogenous pulsatile turkey growth hormone by growing 8-week-old female turkeys. ( Bacon, WL; Long, DW; Vasilatos-Younken, R, 1995)
"When the deaths from cancer were classified as "early" or "late"--that is, occurring less than or more than 2."	1.27	Raised serum urate concentration as risk factor for premature mortality in middle aged men: relation to death from cancer. ( Petersson, B; Trell, E, 1983)
" Results suggest that very-low-calorie diets can be an effective and safe means of substantial weight reduction."	1.27	Safety and effectiveness of weight reduction using a very-low-calorie formulated food. ( Budell, W; Clements, M; Kreitzman, SN; Krissman, P; Nichols, D; Pedersen, M, 1984)
"Body weights were relatively stable over the period of observation."	1.27	Long-term biochemical and physiologic effects of surgically placed portacaval shunts in dogs. ( Buffington, CA; Rogers, QR; Schaeffer, MC; Strombeck, DR; Wolfe, BM, 1986)
" M at a lower dosage than F has demonstrated an effective diuretic response irrespective the degree of renal impairment."	1.27	Step-dose of muzolimine at different stages of chronic renal failure: comparison with furosemide. ( Bazzato, G; Coli, U; Fracasso, A; Landini, S; Morachiello, P; Righetto, F; Scanferla, F, 1985)
"Trichlormethiazide treatment and continued sodium deprivation caused marked losses of body weight and food intake and promotions of urine output and water intake."	1.27	[Decreased renal excretory capacity of uric acid in rats fed a low sodium diet under consecutive administration of thiazide diuretics]. ( Iwaki, K; Yonetani, Y, 1985)
"The urea contents were higher in CG-25."	1.26	The nutritive value and some biochemical aspects of single cell protein obtained from "Saccharomyces, sp.", in rat feeding. ( de Moura, EC; Zucas, SM, 1981)
"It is shown that in osteoarthrosis the clinical characteristics vary from one joint group to another."	1.26	Heberden Oration 1981: epidemiology and the arthritides. ( Acheson, RM, 1982)
"Obesity is very common in South Africal Black girls aged 18 - 20 years."	1.26	Serum high-density lipoprotein cholesterol, glucose tolerance and other variables in obese black adolescent girls. ( Bhamjee, D; Martin, AP; Walker, AR; Walker, BF, 1979)
"Body weight was the most important predictor of SUA in both men and women and superior to measurements involving correction for height, such as ponderal index and calculated lean body mass."	1.26	Serum uric acid in England and Scotland. ( Buchanan, WW; Hart, DP; Kennedy, AC; Scott, JT; Sturge, RA, 1977)
"Forty patients with generalized cancer complicated by water and electrolyte retention were treated with "medium" and "large" doses of furosemide and bumetanide with 35% and 40% objective positive response, respectively."	1.26	Diuretics in malignant effusions and edemas of generalized cancer. ( Athanasiou, A; Dadiotis, L; Razis, DV, 1976)
"the uric acid level was correlated to both the VLDL TG concentration and body weight independently."	1.25	Studies in asymptomatic primary hyperlipidaemia II. Clinical findings. ( Olsson, AG, 1975)
"Obesity was found in 19 per cent of all patients and serum uric acid levels over 0."	1.25	Myocardial infarction in young men. Study of risk factors in nine countries. ( Dolder, MA; Oliver, MF, 1975)
"Osteoarthrosis (OA) scores for the hand and for all body sites were computed for each subject by summing the number of affected joints."	1.25	New Haven survey of joint diseases. XVII. Relationship between some systemic characteristics and osteoarthrosis in a general population. ( Acheson, RM; Collart, AB, 1975)

Research

Studies (751)

Authors

Clinical Trials (20)

Trial Overview

Trial Outcomes

Change in Diastolic Blood Pressure by Cuff 8-10 Weeks Minus Baseline

Timeframe	Studies, this research(%)	All Research%
pre-1990	497 (66.18)	18.7374
1990's	53 (7.06)	18.2507
2000's	80 (10.65)	29.6817
2010's	99 (13.18)	24.3611
2020's	22 (2.93)	2.80

Authors	Studies
Fatimah, SN	1
Usman, SM	1
He, H	1
Pan, L	1
Ren, X	1
Wang, D	1
Du, J	1
Cui, Z	2
Zhao, J	2
Wang, H	1
Wang, X	3
Liu, F	1
Pa, L	1
Peng, X	2
Wang, Y	4
Yu, C	1
Shan, G	1
Vieira, AF	1
Moritz, CEJ	1
Ramis, TR	1
Boeno, FP	1
Dos Santos, GC	1
Lisboa, SC	1
Teodoro, JL	1
Costa, RR	1
Macedo, RCO	1
Reischak-Oliveira, A	1
Yang, F	1
Shi, X	2
Yang, W	1
Gao, C	1
Wang, W	2
He, M	1
Wang, J	1
Liang, Q	1
Li, M	1
Guo, H	1
Deji, C	1
Sui, J	1
Wang, YW	1
Liu, Y	1
Zheng, Y	1
Qian, B	1
Chen, H	2
Ma, M	1
Su, S	1
Geng, H	1
Zhou, WX	1
Guo, X	1
Zhu, WZ	1
Zhang, M	1
Chen, Z	2
Rensen, PCN	1
Hui, CC	1
Shi, B	1
Demirbaş, S	1
Demirbaş, ZA	1
Beyazal, M	1
Kara, E	1
Abdelaziz, MA	1
Ahmed, OM	1
Abdel-Gabbar, M	1
Mohammad, MR	1
Ibrahim, SR	1
Abdelzaher, MH	1
Mohideen, AP	1
Moawd, SA	1
Geddawy, AI	1
Farooq, M	1
Khan, AA	1
Karyadi, B	1
Adika, AR	1
Melani, NAA	1
Parlindungan, D	1
Nursaadah, E	1
Ruyani, A	1
Li, H	3
Fang, G	1
Huang, C	1
An, W	1
Bai, X	1
Huang, Y	1
Mizuno, Y	1
Yamamotoya, T	1
Nakatsu, Y	1
Ueda, K	1
Matsunaga, Y	1
Inoue, MK	1
Sakoda, H	1
Fujishiro, M	1
Ono, H	1
Kikuchi, T	1
Takahashi, M	2
Morii, K	1
Sasaki, K	1
Masaki, T	1
Asano, T	1
Kushiyama, A	1
Vedder, D	1
Walrabenstein, W	1
Heslinga, M	1
de Vries, R	1
Nurmohamed, M	1
van Schaardenburg, D	1
Gerritsen, M	1
Pasyar, S	1
Wilson, LM	1
Pudwell, J	1
Peng, YP	1
Smith, GN	1
Oke, OE	1
Alo, ET	1
Oke, FO	1
Oyebamiji, YA	1
Ijaiya, MA	1
Odefemi, MA	1
Kazeem, RY	1
Soyode, AA	1
Aruwajoye, OM	1
Ojo, RT	1
Adeosun, SM	1
Onagbesan, OM	1
Hlophe, NB	1
Opoku, AR	1
Osunsanmi, FO	1
Djarova-Daniels, TG	1
Lawal, OA	1
Mosa, RA	1
Aliena-Valero, A	1
Rius-Pérez, S	1
Baixauli-Martín, J	1
Torregrosa, G	1
Chamorro, Á	1
Pérez, S	1
Salom, JB	1
Shimizu, W	1
Kubota, Y	1
Hoshika, Y	1
Mozawa, K	1
Tara, S	1
Tokita, Y	1
Yodogawa, K	1
Iwasaki, YK	1
Yamamoto, T	3
Takano, H	1
Tsukada, Y	1
Asai, K	1
Miyamoto, M	1
Miyauchi, Y	1
Kodani, E	1
Ishikawa, M	1
Maruyama, M	1
Ogano, M	1
Tanabe, J	1
Ohashi, N	1
Aoki, T	1
Matsuyama, T	1
Ishigaki, S	1
Isobe, S	1
Fujikura, T	1
Hashimoto, T	1
Tsuriya, D	1
Morita, H	1
Kato, A	1
Yasuda, H	1
Xun, ZM	1
Zhao, QH	1
Zhang, Y	5
Ju, FD	1
He, J	1
Yao, TT	1
Zhang, XK	1
Yi, Y	1
Ma, SN	1
Zhao, PX	1
Jin, XY	1
Li, YX	1
Li, XY	1
Ma, XM	1
Xie, F	1
Nakamura, T	1
Nampei, M	1
Murase, T	1
Satoh, E	1
Akari, S	1
Katoh, N	1
Mizukami, H	1
Mahdavi-Roshan, M	1
Salari, A	1
Ghorbani, Z	1
Nikpey, Z	1
Haghighatkhah, M	1
Fakhr Mousavi, A	1
Gholipour, M	1
Pourfarzad, A	1
Zhang, X	1
Nie, Q	1
Zhang, Z	1
Zhang, F	1
Wang, C	2
Song, G	1
Fan, N	1
Yu, Y	1
Li, L	1
Xia, H	1
Dong, X	1
Li, Y	2
Duan, W	1
Cebula, A	1
Tyka, AK	1
Pilch, W	1
Szyguła, Z	1
Pałka, T	1
Sztafa-Cabała, K	1
Frączek, B	1
Tyka, A	1
Kuge, R	1
Morikawa, Y	1
Hasegawa, Y	1
Viblanc, VA	1
Schull, Q	1
Cornioley, T	1
Stier, A	1
Ménard, JJ	1
Groscolas, R	3
Robin, JP	3
Dye, JA	1
Gibbs-Flournoy, EA	1
Richards, JH	1
Norwood, J	1
Kraft, K	1
Hatch, GE	1
Deng, T	1
Mai, Z	1
Cai, C	1
Duan, X	1
Zhu, W	1
Zhang, T	1
Wu, W	1
Zeng, G	1
Liu, JR	1
Liu, BW	1
Yin, FZ	1
Maness, TJ	1
Anderson, DJ	1
Boutin, A	1
Blackman, A	1
O'Sullivan, DM	1
Forcello, N	1
Mojto, V	1
Gvozdjakova, A	1
Kucharska, J	1
Rausova, Z	1
Vancova, O	1
Valuch, J	1
Ito, M	1
Tanaka, T	1
Büsing, F	1
Hägele, FA	1
Nas, A	1
Döbert, LV	1
Fricker, A	1
Dörner, E	1
Podlesny, D	1
Aschoff, J	1
Pöhnl, T	1
Schweiggert, R	1
Fricke, WF	1
Carle, R	1
Bosy-Westphal, A	2
Hirai, T	1
Itoh, T	1
Kimura, T	1
Echizen, H	1
Saeed, OA	1
Sazili, AQ	1
Akit, H	1
Alimon, AR	1
Samsudin, AAB	1
Park, SK	1
Rosenthal, TR	1
Williams, JS	1
Shelton, JM	1
Zhang, S	1
Bobulescu, IA	1
Adewole, KE	1
Adebayo, JO	1
Ferron, AJT	1
Francisqueti, FV	1
Minatel, IO	1
Silva, CCVA	1
Bazan, SGZ	1
Kitawara, KAH	1
Garcia, JL	1
Corrêa, CR	1
Moreto, F	1
Ferreira, ALA	1
Tian, TT	1
Chen, SJ	1
Wang, Q	1
Tian, QW	1
Zhang, BB	1
Zhu, J	1
He, GW	1
Lun, LM	1
Xuan, C	1
Saleem, M	1
Javed, F	1
Asif, M	1
Baig, MK	1
Arif, M	1
Badejogbin, C	1
Areola, DE	1
Olaniyi, KS	1
Adeyanju, OA	1
Adeosun, IO	1
Srettabunjong, S	1
Thongphap, W	1
Chittamma, A	1
Gomes, JMG	1
de Assis Costa, J	1
Ribeiro, PVM	1
Alfenas, RCG	1
McBride, A	1
Lathon, SC	1
Boehmer, L	1
Augustin, KM	1
Butler, SK	1
Westervelt, P	1
Sakhno, LA	1
Yurchenko, OV	1
Maslenniy, VN	1
Bardakhivskaya, KI	1
Nikolaeva, VV	1
Ivanyuk, AA	1
Shevchuk, OO	1
Korotich, VG	1
Nikolaev, VG	1
Meitern, R	1
Sild, E	1
Kilk, K	1
Porosk, R	1
Hõrak, P	1
Perry, GM	1
Scheinman, SJ	1
Asplin, JR	1
Dalbeth, N	1
Pool, B	1
Yip, S	1
Cornish, J	1
Murphy, R	1
Kemter, E	2
Prueckl, P	1
Sklenak, S	1
Rathkolb, B	2
Habermann, FA	1
Hans, W	2
Gailus-Durner, V	2
Fuchs, H	2
Hrabě de Angelis, M	2
Wolf, E	2
Aigner, B	2
Wanke, R	2
Ogunlana, OO	1
Ogunlana, OE	1
Adeneye, AA	1
Udo-Chijioke, O	1
Dare-Olipede, T	1
Olagunju, JA	1
Akindahunsi, AA	1
Dziuba, J	1
Alperin, P	1
Racketa, J	1
Iloeje, U	1
Goswami, D	1
Hardy, E	1
Perlstein, I	1
Grossman, HL	1
Cohen, M	1
Bindler, RC	1
Daratha, KB	1
Bindler, RJ	1
Short, R	1
Oyewo, EB	1
Adetutu, A	1
Adebisi, JA	1
Al Wakeel, JS	1
Jówko, E	1
Długołęcka, B	1
Makaruk, B	1
Cieśliński, I	1
Mahmoud, AA	1
Elshazly, SM	1
Foerster, J	1
Maskarinec, G	1
Reichardt, N	1
Tett, A	1
Narbad, A	1
Blaut, M	1
Boeing, H	1
Angelopoulos, TJ	1
Lowndes, J	1
Sinnett, S	1
Rippe, JM	1
Araoud, M	1
Neffeti, F	1
Douki, W	1
Khaled, L	1
Najjar, MF	1
Kenani, A	1
Houas, Z	1
Kuriyama, S	1
Nakano, T	1
Maruyama, Y	1
Sugano, N	1
Takane, K	1
Suetsugu, Y	1
Takahashi, Y	1
Kobayashi, C	1
Nishio, S	1
Takahashi, D	1
Kidoguchi, S	1
Ichida, K	1
Ohno, I	1
Hosoya, T	1
Yokoo, T	1
Ibrahim, SM	1
El-Denshary, ES	1
Abdallah, DM	1
Baş, H	1
Kalender, Y	1
Chin, SC	1
Lien, CY	1
Chan, Y	1
Chen, CL	1
Yang, Y	1
Yeh, LS	1
Wu, Y	1
Liu, L	1
de Miranda, JA	1
Almeida, GG	1
Martins, RI	1
Cunha, MB	1
Belo, VA	1
dos Santos, JE	1
Mourão-Júnior, CA	1
Lanna, CM	1
Liang, N	1
Wang, F	1
Fang, J	1
Cui, H	1
Lai, W	1
Zhou, Y	1
Geng, Y	1
Weber, MA	1
Mansfield, TA	1
Alessi, F	1
Iqbal, N	1
Parikh, S	1
Ptaszynska, A	1
Karimi, P	1
Farhangi, MA	1
Sarmadi, B	1
Gargari, BP	1
Zare Javid, A	1
Pouraghaei, M	1
Dehghan, P	1
Bertoli, S	1
Leone, A	1
Vignati, L	1
Spadafranca, A	1
Bedogni, G	1
Vanzulli, A	1
Rodeschini, E	1
Battezzati, A	1
Kastorini, CM	1
Panagiotakos, DB	1
Georgousopoulou, EN	1
Laskaris, A	1
Skourlis, N	1
Zana, A	1
Chatzinikolaou, C	1
Chrysohoou, C	1
Puddu, PE	1
Tousoulis, D	1
Stefanadis, C	1
Pitsavos, C	1
Sammito, S	1
Chen, YM	1
Lin, CL	1
Wei, L	2
Hsu, YJ	1
Chen, KN	1
Huang, CC	1
Kao, CH	1
Wu, L	1
Song, X	1
Luo, C	1
Meng, X	1
Yuan, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
An Intervention Study of Intermittent Fasting and Low Carbon Diet in Patients With Metabolic Syndrome[NCT04475822]		169 participants (Actual)	Interventional	2020-07-12	Completed
Molecular Targets Open for Regulation by the Gut Flora - New Avenues for Improved Diet to Optimize European Health (TORANDO): WP2 Individual Intervention Studies- Effect of Diet on Intestinal Microbiota and Obesity Markers in Adults[NCT01449383]		20 participants (Actual)	Interventional	2010-11-30	Completed
A Comparison of the Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels on Liver and Muscle Fatty Infiltration, Insulin Resistance, Glucose, Insulin, Leptin, Ghrelin, Postprandial Triglycerides[NCT01797042]		366 participants (Actual)	Interventional	2012-03-31	Completed
A Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes[NCT02887677]	Phase 4	85 participants (Actual)	Interventional	2016-10-31	Terminated (stopped due to On February 2019 Astra-Zeneca Greece decided to stop the financial support of the study.)
Evaluation of Quercetin in Type 2 Diabetes: Impact on Glucose Tolerance and Postprandial Endothelial Function.[NCT01839344]	Phase 2	19 participants (Actual)	Interventional	2013-05-31	Completed
Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I[NCT03665636]	Early Phase 1	4 participants (Actual)	Interventional	2020-10-16	Completed
Monitoring of Metabolic Adverse Events of Second Generation Antipsychotics in a Naive Pediatric Population Followed in Mental Health Outpatient and Inpatient Clinical Settings (MEMAS Prospective Study)[NCT04395326]		120 participants (Anticipated)	Observational	2017-01-01	Recruiting
Uric Acid and Hypertension in African Americans[NCT00241839]	Phase 3	150 participants (Actual)	Interventional	2005-08-31	Completed
[NCT00000482]	Phase 3	0 participants	Interventional	1965-04-30	Completed
[NCT00005140]		0 participants	Observational	1977-09-30	Completed
[NCT00005128]		0 participants	Observational	1972-07-31	Completed
Hypertonic Saline With Furosemide and a Normosodic Diet for the Treatment of Decompensated Congestive Heart Failure With Prerenal Physiology[NCT00575484]	Phase 2	11 participants (Actual)	Interventional	2007-11-30	Terminated
HSS (Hypertonic Saline Solution) Plus High Dose Furosemide vs High Dose Furosemide in Nephrotic Syndrome - a Randomized Trial[NCT03750136]		30 participants (Anticipated)	Interventional	2018-12-15	Recruiting
[NCT00005125]		0 participants	Observational	1970-07-31	Completed
Pancreatic Enzyme Replacement Therapy (PERT) for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer[NCT02985801]	Phase 1/Phase 2	16 participants (Actual)	Interventional	2016-12-31	Terminated (stopped due to Study was terminated due to difficulty in recruiting subjects.)
[NCT00005123]		0 participants	Observational	1965-07-31	Completed
[NCT00000485]	Phase 3	0 participants	Interventional	1971-05-31	Completed
[NCT00005122]		0 participants	Observational	1958-07-31	Completed
[NCT00000487]	Phase 3	0 participants	Interventional	1972-06-30	Completed
The Relationship Between Uric Acid and Inflammatory Markers[NCT01323335]	Phase 1	97 participants (Actual)	Interventional	2009-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo

Change in Overall Mean BP From Those Obtained by 24 Hour Ambulatory Blood Pressure Measurements (ABPM) 8-10 Weeks Minus Baseline.

Intervention	mm Hg (Mean)
A (Allopurinol)	3.44
B (Placebo)	-0.83

Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)

Change in Systolic Blood Pressure by Cuff After 8-10 Weeks Minus Baseline

Intervention	mm Hg (Mean)
A (Allopurinol)	-5.9
B (Placebo)	0.90

"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo

Change in Uric Acid (UA) Levels: Baseline Less End of Treatment

Intervention	mm Hg (Mean)
A (Allopurinol)	0.21
B (Placebo)	-0.95

Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)

Article	Year
Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review. Nutrients, 2019, Dec-04, Volume: 11, Issue:12 Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Weight; Cardiovascular Diseases; Dietary Supplement	2019
The Anticipated Renoprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors. Internal medicine (Tokyo, Japan), 2018, Aug-01, Volume: 57, Issue:15 Topics: Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Fibrosis; Glucose; Humans; Hypoglycemic Agen	2018
New Oral Hypoglycemic Agents and Cardiovascular Risk. Crossing the Metabolic Border. Revista espanola de cardiologia (English ed.), 2016, Volume: 69, Issue:11 Topics: Benzhydryl Compounds; Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Cardiovascular Dise	2016
Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies. Expert opinion on drug metabolism & toxicology, 2017, Volume: 13, Issue:4 Topics: Albuminuria; Animals; Blood Pressure; Body Weight; Cholesterol, LDL; Diabetes Mellitus, Type 2; Gluc	2017
[SIGNIFICANCE OF THE INTRAVENOUS USE OF EMULSIONS PRE- AND POST-OPERATIVELY WITH SPECIAL REFERENCE TO OLD PEOPLE]. [Sogo rinsho] Clinic all-round, 1964, Volume: 13 Topics: Amino Acids; Blood Proteins; Body Weight; Cholesterol; Emulsions; Fever; Gastrectomy; Geriatrics; Gl	1964
[Hyperuric acidemia and obesity]. Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53 Suppl Topics: Age Factors; Body Weight; Diet; Female; Humans; Male; Obesity; Uric Acid	1995
Jejunoileal bypass for morbid obesity. A critical appraisal. The American journal of medicine, 1978, Volume: 64, Issue:3 Topics: Adaptation, Physiological; Adult; Blood Glucose; Blood Pressure; Body Weight; Cholelithiasis; Humans	1978
Dietetic treatment of obesity with low and high-carbohydrate diets: comparative studies and clinical results. International journal of obesity, 1979, Volume: 3, Issue:3 Topics: Adult; Blood Glucose; Body Weight; Cholesterol; Diet, Reducing; Dietary Carbohydrates; Dietary Fats;	1979
[Significance of physical activity in the prevention of degenerative heart and vascular diseases?]. Deutsche medizinische Wochenschrift (1946), 1976, Feb-06, Volume: 101, Issue:6 Topics: Adult; Age Factors; Arteriosclerosis; Body Weight; Cerebral Hemorrhage; Cerebrovascular Disorders; C	1976
[The Fuenlabrada study: lipids and lipoproteins in children and adolescents]. Anales espanoles de pediatria, 1989, Volume: 31, Issue:4 Topics: Adolescent; Age Factors; Blood Glucose; Body Height; Body Weight; Child; Child, Preschool; Female; H	1989
Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs, 1985, Volume: 30, Issue:4 Topics: Animals; Body Weight; Diuretics; Edema; Electrolytes; Half-Life; Humans; Hypertension; Intestinal Ab	1985
Fasting in the treatment of obesity. The Practitioner, 1972, Volume: 208, Issue:246 Topics: Adolescent; Body Weight; Diet, Reducing; Fasting; Hospitalization; Humans; Hypokalemia; Middle Aged;	1972
The pathogenesis of hypercholesterolemia. Annals of internal medicine, 1974, Volume: 80, Issue:6 Topics: Age Factors; Animals; Anxiety; Body Weight; Cholesterol; Diabetes Complications; Diet; Dietary Fats;	1974
Hypertension and renal disease in pregnancy. The Medical clinics of North America, 1971, Volume: 55, Issue:1 Topics: Adrenal Cortex Hormones; Animals; Biopsy; Body Weight; Diet, Sodium-Restricted; Eclampsia; Edema; Fe	1971

Article	Year
Chronic aerobic exercise prevents high-fructose diet-induced impairment in blood pressure in healthy young adults: a double-blind, randomised clinical trial. The British journal of nutrition, 2022, 11-28, Volume: 128, Issue:10 Topics: Blood Glucose; Blood Pressure; Body Weight; Diet; Exercise; Fructose; Glucose; Humans; Uric Acid; Yo	2022
Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial. Cell reports. Medicine, 2022, 10-18, Volume: 3, Issue:10 Topics: Blood Glucose; Body Weight; Diet, Carbohydrate-Restricted; Dyslipidemias; Humans; Intra-Abdominal Fa	2022
Early age thermal manipulation on the performance and physiological response of broiler chickens under hot humid tropical climate. Journal of thermal biology, 2020, Volume: 88 Topics: Animals; Blood Glucose; Body Temperature; Body Weight; Chickens; Creatinine; Hot Temperature; Humidi	2020
Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus: the EMBODY trial. Cardiovascular diabetology, 2020, 09-25, Volume: 19, Issue:1 Topics: 3-Iodobenzylguanidine; Aged; Benzhydryl Compounds; Blood Pressure; Body Weight; Death, Sudden, Cardi	2020
Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients. Medical science monitor : international medical journal of experimental and clinical research, 2020, Oct-02, Volume: 26 Topics: Adiposity; Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle	2020
The effects of rice bran oil on left ventricular systolic function, cardiometabolic risk factors and inflammatory mediators in men with coronary artery disease: a randomized clinical trial. Food & function, 2021, May-21, Volume: 12, Issue:10 Topics: Adult; Aged; Blood Glucose; Body Weight; C-Reactive Protein; Cardiometabolic Risk Factors; Coronary	2021
Uric acid and dehydration in children with gastroenteritis. Pediatrics international : official journal of the Japan Pediatric Society, 2017, Volume: 59, Issue:11 Topics: Biomarkers; Body Weight; Child, Preschool; Dehydration; Female; Fluid Therapy; Gastroenteritis; Huma	2017
High intake of orange juice and cola differently affects metabolic risk in healthy subjects. Clinical nutrition (Edinburgh, Scotland), 2019, Volume: 38, Issue:2 Topics: Adult; Blood Glucose; Body Weight; Carbonated Beverages; Citrus sinensis; Cross-Over Studies; Diet;	2019
High calcium intake from fat-free milk, body composition and glycaemic control in adults with type 2 diabetes: a randomised crossover clinical trial. The British journal of nutrition, 2019, 08-14, Volume: 122, Issue:3 Topics: Adult; Animals; Body Composition; Body Mass Index; Body Weight; Calcium, Dietary; Cross-Over Studies	2019
The effect of green tea extract supplementation on exercise-induced oxidative stress parameters in male sprinters. European journal of nutrition, 2015, Volume: 54, Issue:5 Topics: Ascorbic Acid; beta Carotene; Biomarkers; Body Mass Index; Body Weight; Creatine Kinase; Cross-Over	2015
The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial. PloS one, 2014, Volume: 9, Issue:10 Topics: Actinobacteria; Adult; Bacterial Typing Techniques; Body Weight; Clostridium; Creatinine; Cross-Over	2014
Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption. Journal of clinical hypertension (Greenwich, Conn.), 2015, Volume: 17, Issue:2 Topics: Adult; Blood Pressure; Body Weight; Dietary Carbohydrates; Energy Intake; Female; Fructose; Humans;	2015
Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade. Blood pressure, 2016, Volume: 25, Issue:2 Topics: Adult; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzhydryl Compounds; Blood	2016
The Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial. Annals of nutrition & metabolism, 2016, Volume: 68, Issue:2 Topics: Adult; Aged; Antioxidants; Biomarkers; Blood Glucose; Body Weight; C-Reactive Protein; Diabetes Mell	2016
Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial. BMC cardiovascular disorders, 2016, 10-04, Volume: 16, Issue:1 Topics: Adrenergic beta-1 Receptor Antagonists; Age Factors; Aged; Amiloride; Antihypertensive Agents; Ateno	2016
Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. The British journal of nutrition, 2009, Volume: 102, Issue:7 Topics: Adult; Aged; Anthropometry; Antioxidants; Blood Glucose; Blood Pressure; Body Composition; Body Weig	2009
Phase III clinical pharmacology study of tolvaptan. Cardiovascular drugs and therapy, 2011, Volume: 25 Suppl 1 Topics: Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Asian People; Benzazepines; Body	2011
The effects of surgically removing subcutaneous fat on the metabolic profile and insulin sensitivity in obese women after large-volume liposuction treatment. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2002, Volume: 34, Issue:8 Topics: Adipose Tissue; Adult; Blood Glucose; Body Height; Body Mass Index; Body Weight; Cholesterol, LDL; F	2002
Effect of selective and nonselective beta-blockers on resting energy production rate and total body substrate utilization in chronic heart failure. Journal of cardiac failure, 2002, Volume: 8, Issue:6 Topics: Adipose Tissue; Adrenergic beta-Antagonists; Aged; Basal Metabolism; Bisoprolol; Blood Pressure; Bod	2002
Oxidized low-density lipoprotein autoantibodies in patients with primary gout: effect of urate-lowering therapy. Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 339, Issue:1-2 Topics: Allopurinol; Antioxidants; Autoantibodies; Body Weight; Case-Control Studies; Cholesterol, HDL; Chol	2004
Metabolic and anthropometric changes one year after switching from didanosine/stavudine to tenofovir in HIV-infected patients. European journal of medical research, 2007, Feb-26, Volume: 12, Issue:2 Topics: Adenine; Adult; Aged; Anti-HIV Agents; Body Weight; CD4 Lymphocyte Count; Cholesterol; Cholesterol,	2007
Population pharmacokinetic and pharmacodynamic analysis of pegloticase in subjects with hyperuricemia and treatment-failure gout. Journal of clinical pharmacology, 2008, Volume: 48, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Body Weight; Dose-Response Relationship, Drug; Drug Administration S	2008
Low sodium/high potassium diet for prevention of hypertension: probable mechanisms of action. Lancet (London, England), 1981, Oct-24, Volume: 2, Issue:8252 Topics: Adult; Blood Pressure; Body Weight; Creatine; Diet, Sodium-Restricted; Humans; Hypertension; Male; P	1981
Multicentre controlled trial of tienilic acid in hyperuricaemic, hypertensive subjects, with intensive monitoring of liver function. British journal of clinical pharmacology, 1983, Volume: 15, Issue:5 Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Creatinine; Electrolytes; Female; Glycolates; Hu	1983
Double-blind comparison between propranolol and bendroflumethiazide in captopril-treated resistant hypertensive patients. American heart journal, 1983, Volume: 106, Issue:2 Topics: Bendroflumethiazide; Body Weight; Captopril; Clinical Trials as Topic; Double-Blind Method; Drug Res	1983
Increased plasma vasopressin and serum uric acid in the low renin type of essential hypertension. Acta medica Scandinavica, 1984, Volume: 215, Issue:2 Topics: Atenolol; Blood Pressure; Body Weight; Catecholamines; Heart Rate; Humans; Hypertension; Male; Middl	1984
Blood pressure in survivors of myocardial infarction. The Coronary Drug Project Research Group. Journal of the American College of Cardiology, 1984, Volume: 4, Issue:6 Topics: Adult; Age Factors; Blood Glucose; Blood Pressure; Body Weight; Electrocardiography; Heart Rate; Hum	1984
[Does short-term fasting lower the cardiovascular risk in obesity? Effects of the composition of the reducing diet]. Fortschritte der Medizin, 1983, Sep-15, Volume: 101, Issue:35 Topics: Adult; Blood Glucose; Body Weight; Diet, Reducing; Dietary Fats; Female; Humans; Hypertension; Male;	1983
[Reduction of body weight with diets high in butter and margarine content]. Fortschritte der Medizin, 1983, Nov-03, Volume: 101, Issue:41 Topics: Adult; Blood Glucose; Body Weight; Butter; Diet, Reducing; Dietary Fats; Female; Hemoglobins; Humans	1983
Serum lipoprotein levels during chlorthalidone therapy. A Veterans Administration-National Heart, Lung, and Blood Institute cooperative study on antihypertensive therapy: mild hypertension. JAMA, 1980, Oct-10, Volume: 244, Issue:15 Topics: Adult; Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as T	1980
The action of benzbromarone in relation to age, sex and accompanying diseases. Advances in experimental medicine and biology, 1980, Volume: 122A Topics: Benzbromarone; Benzofurans; Body Height; Body Weight; Clinical Trials as Topic; Female; Follow-Up St	1980
Metabolic effects of substituting carbohydrate for protein in a low-calorie diet: a prolonged study in obese patients. International journal of obesity, 1981, Volume: 5, Issue:3 Topics: 3-Hydroxybutyric Acid; Adult; Body Weight; Diet, Reducing; Dietary Carbohydrates; Dietary Proteins;	1981
The effect of chlorothiazide on bone-related biochemical variables in normal post-menopausal women. Journal of the American Geriatrics Society, 1993, Volume: 41, Issue:5 Topics: Acid-Base Equilibrium; Aged; Biomarkers; Body Weight; Bone Resorption; Calcium; Chlorothiazide; Crea	1993
Metabolic effects of strict salt restriction in essential hypertensive patients. Journal of internal medicine, 1993, Volume: 233, Issue:5 Topics: Adult; Aged; Blood Pressure; Body Weight; Creatinine; Diet, Sodium-Restricted; Double-Blind Method;	1993
[Lactovegetarian diet: effect on changes in body weight, lipid status, fibrinogen and lipoprotein (a) in cardiovascular patients during inpatient rehabilitation treatment]. Zeitschrift fur Kardiologie, 1996, Volume: 85, Issue:6 Topics: Adult; Aged; Body Weight; Cardiac Rehabilitation; Cardiovascular Diseases; Cholesterol; Cholesterol,	1996
A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. The American journal of clinical nutrition, 1996, Volume: 64, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Animals; Blood Pressure; Blood Urea Nitrogen; Body Weight; Chlorides	1996
Urinary excretion of minerals, oxalate, and uric acid in north Indian children. Pediatric nephrology (Berlin, Germany), 1997, Volume: 11, Issue:2 Topics: Adolescent; Aging; Body Height; Body Mass Index; Body Weight; Calcium; Child; Creatinine; Female; Hu	1997
Changes in blood pressure and in vasoactive and volume regulatory hormones during semistarvation in obese subjects. Metabolism: clinical and experimental, 1998, Volume: 47, Issue:5 Topics: Adolescent; Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Blood Urea Nitrogen; Body	1998
Effects of acute and repeated oral doses of D-tagatose on plasma uric acid in normal and diabetic humans. Regulatory toxicology and pharmacology : RTP, 1999, Volume: 29, Issue:2 Pt 2 Topics: Blood Pressure; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diet; Di	1999
Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. European journal of heart failure, 2000, Volume: 2, Issue:3 Topics: Aged; Aged, 80 and over; Blood Pressure; Body Weight; Creatinine; Diuresis; Diuretics; Drug Therapy,	2000
Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. European journal of heart failure, 2000, Volume: 2, Issue:3 Topics: Aged; Aged, 80 and over; Blood Pressure; Body Weight; Creatinine; Diuresis; Diuretics; Drug Therapy,	2000
Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. European journal of heart failure, 2000, Volume: 2, Issue:3 Topics: Aged; Aged, 80 and over; Blood Pressure; Body Weight; Creatinine; Diuresis; Diuretics; Drug Therapy,	2000
Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. European journal of heart failure, 2000, Volume: 2, Issue:3 Topics: Aged; Aged, 80 and over; Blood Pressure; Body Weight; Creatinine; Diuresis; Diuretics; Drug Therapy,	2000
Effect of dietary supplements containing antioxidants on attenuation of muscle damage in exercising sled dogs. American journal of veterinary research, 2000, Volume: 61, Issue:11 Topics: Animals; Antioxidants; Ascorbic Acid; Body Weight; Cholesterol; Creatine Kinase; Dietary Supplements	2000
Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16 Suppl 1 Topics: Albuminuria; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus,	2001
The effect of metoprolol --a new selective adrenergic beta1-receptor blocking agent-- in mild hypertension. Acta medica Scandinavica, 1976, Volume: 199, Issue:1-2 Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Pressure; Body Weight; Clinical Trials as Topic; Depr	1976
Comparison between metoprolol and propranolol as antihypertensive agents. A double-blind cross-over study. Acta medica Scandinavica, 1976, Volume: 199, Issue:1-2 Topics: Adrenergic beta-Antagonists; Blood Pressure; Body Weight; Clinical Trials as Topic; Depression, Chem	1976
Comparison of tienilic acid with cyclopenthiazide in hyperuricaemic hypertensive patients. Lancet (London, England), 1978, Sep-16, Volume: 2, Issue:8090 Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Cyclopenthiazide; Diuretics; Drug Evaluation;	1978
Clinical study of ticrynafen. A new diuretic, antihypertensive, and uricosuric agent. JAMA, 1977, Feb-14, Volume: 237, Issue:7 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Diureti	1977
Diuretic therapies in low renin and normal renin essential hypertension. Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:1 Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Combinations	1977
Effects of halofenate and probenecid on serum lipids and uric acid in hyperlipidemic, hyperuricemic adults. Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:3 Topics: Adult; Aged; Body Weight; Cholesterol; Clinical Trials as Topic; Female; Glycolates; Halofenate; Hum	1977
Antihypertensive therapy in elderly patients. Pilot trial of the European Working Party on High Blood Pressure in the Elderly. Gerontology, 1977, Volume: 23, Issue:6 Topics: Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Female; Humans; Hydrochloro	1977
A chronopharmacological study on hydrochlorthiazide. International journal of chronobiology, 1977, Volume: 4, Issue:4 Topics: Adolescent; Adult; Blood Pressure; Body Weight; Calcium; Chlorides; Circadian Rhythm; Clinical Trial	1977
Ticrynafen: a novel uricosuric antihypertensive natriuretic agent. Archives of internal medicine, 1978, Volume: 138, Issue:1 Topics: Blood Pressure; Blood Urea Nitrogen; Blood Volume; Body Weight; Clinical Trials as Topic; Creatinine	1978
Antihypertensive therapy in patients above age 60. Third interim report of the European Working Party on High blood pressure in Elderly (EWPHE). Acta cardiologica, 1978, Volume: 33, Issue:2 Topics: Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Double-Blind Method; Europe	1978
A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension. British journal of clinical pharmacology, 1978, Volume: 6, Issue:4 Topics: Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Chlorides; Clinical T	1978
Antihypertensive therapy in patients above age 60 years (Fourth Interim report of the European Working Party on High Blood pressure in Elderly: EWPHE). Clinical science and molecular medicine. Supplement, 1978, Volume: 4 Topics: Aged; Aging; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Doubl	1978
[A pilot and a controlled study of the influence of ethambutol on serum urate concentration and uric acid clearance (author's transl)]. Praxis und Klinik der Pneumologie, 1979, Volume: 33, Issue:11 Topics: Alcoholism; Body Weight; Creatinine; Ethambutol; Humans; Isoniazid; Rifampin; Streptomycin; Tubercul	1979
Treatment of benign essential hypertension: comparison of furosemide and hydrochlorothiazide. European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6 Topics: Adult; Bicarbonates; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuresis; Dose-Response	1975
Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents. European journal of clinical pharmacology, 1976, Volume: 10, Issue:6 Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart	1976
Effect of diet composition on metabolic adaptations to hypocaloric nutrition: comparison of high carbohydrate and high fat isocaloric diets. The American journal of clinical nutrition, 1977, Volume: 30, Issue:2 Topics: Adolescent; Adult; Blood Glucose; Body Weight; Diet, Reducing; Dietary Carbohydrates; Dietary Fats;	1977
Mechanisms of the uricosuric effect of the diuretic tienilic acid (Ticrynafen) in man. Clinical science and molecular medicine, 1977, Volume: 53, Issue:4 Topics: Adult; Biological Transport; Body Weight; Glomerular Filtration Rate; Glycolates; Humans; Kidney Tub	1977
Wine versus ethanol in human nutrition. I. Nitrogen and calorie balance. The American journal of clinical nutrition, 1976, Volume: 29, Issue:10 Topics: Adult; Blood Proteins; Blood Urea Nitrogen; Body Weight; Creatinine; Energy Metabolism; Ethanol; Hum	1976
A double-blind study in hypertensive patients of an original new compound, indapamide. Current medical research and opinion, 1975, Volume: 3, Issue:1 Topics: Adult; Antihypertensive Agents; Benzamides; Blood Pressure Determination; Blood Proteins; Blood Urea	1975
Clinical use of NISR 440 polycarbonate membrane for hemodialysis. Transactions - American Society for Artificial Internal Organs, 1975, Volume: 21 Topics: Adult; Aged; Biocompatible Materials; Blood Flow Velocity; Blood Urea Nitrogen; Body Weight; Carbona	1975
A double-blind, randomized, placebo-controlled comparison of the metabolic effects of low-dose hydrochlorothiazide and indapamide. Journal of clinical pharmacology, 1991, Volume: 31, Issue:8 Topics: Blood Pressure; Body Weight; Double-Blind Method; Female; Heart Rate; Humans; Hydrochlorothiazide; H	1991
Clinical multicenter study of Hemoflow F6 in comparison with different standard dialyzers. Contributions to nephrology, 1989, Volume: 74 Topics: Adult; Aged; Aged, 80 and over; Antibodies; beta 2-Microglobulin; Biocompatible Materials; Body Weig	1989
Comparison of the metabolic effects of long-term treatment with pindolol or atenolol by hypertensive patients. Cardiovascular drugs and therapy, 1988, Volume: 1, Issue:5 Topics: Adult; Atenolol; Blood Glucose; Body Weight; Cholesterol, LDL; Cholesterol, VLDL; Drug Administratio	1988
Comparative pharmacodynamics of torasemide and furosemide in patients with oedema. Arzneimittel-Forschung, 1988, Volume: 38, Issue:1A Topics: Aged; Aged, 80 and over; Blood Pressure; Blood Urea Nitrogen; Body Weight; Clinical Trials as Topic;	1988
Comparison of efficacy and tolerance of different oral doses of torasemide and furosemide in patients with advanced chronic renal failure. Arzneimittel-Forschung, 1988, Volume: 38, Issue:1A Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Diuretics; Double-Bl	1988
The effects of bendroflumethiazide added to nifedipine in patients with hypertension. Journal of clinical pharmacology, 1987, Volume: 27, Issue:1 Topics: Adult; Bendroflumethiazide; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; De	1987
Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. Journal of the American Geriatrics Society, 1986, Volume: 34, Issue:3 Topics: Age Factors; Aged; Blood Glucose; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic	1986
Torasemide, a new potent diuretic. Double-blind comparison with furosemide. European journal of clinical pharmacology, 1986, Volume: 31 Suppl Topics: Aged; Aged, 80 and over; Body Weight; Clinical Trials as Topic; Creatinine; Diuretics; Double-Blind	1986
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension. Journal of chronic diseases, 1985, Volume: 38, Issue:4 Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D	1985
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension. Journal of chronic diseases, 1985, Volume: 38, Issue:4 Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D	1985
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension. Journal of chronic diseases, 1985, Volume: 38, Issue:4 Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D	1985
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension. Journal of chronic diseases, 1985, Volume: 38, Issue:4 Topics: Blood Glucose; Blood Pressure; Body Weight; Chlorthalidone; Cholesterol; Clinical Trials as Topic; D	1985
Hypertension management in the Multiple Risk Factor Intervention Trial (MRFIT). Six-year intervention results for men in special intervention and usual care groups. Archives of internal medicine, 1985, Volume: 145, Issue:7 Topics: Adult; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clinical Tr	1985
[Esmaloride--a new potassium neutral diuretic combination. Clinical pharmacologic properties]. Fortschritte der Medizin, 1985, Feb-14, Volume: 103, Issue:6 Topics: Aldosterone; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Drug Combinations; F	1985
Studies of bladder stone disease in Thailand. X. Effect of orthophosphate and nonfat dry milk supplementations on urine composition. The American journal of clinical nutrition, 1969, Volume: 22, Issue:2 Topics: Age Factors; Animals; Body Height; Body Weight; Calcium; Child Nutritional Physiological Phenomena;	1969
Clinical trial of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370) in painful osteoarticular conditions. Arzneimittel-Forschung, 1972, Volume: 22, Issue:1 Topics: Adult; Aged; Anti-Inflammatory Agents; Blood Cell Count; Body Weight; Clinical Trials as Topic; Diur	1972
Comparison between alprenolol and chlorthalidone as antihypertensive agents. Acta medica Scandinavica, 1972, Volume: 191, Issue:5 Topics: Adult; Alprenolol; Amino Alcohols; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as T	1972
Comparison between alprenolol and propranolol as antihypertensive agents. A double-blind cross-over study. Acta medica Scandinavica, 1972, Volume: 192, Issue:5 Topics: Adult; Alprenolol; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart Rate; Humans	1972
Moderate sodium restriction and diuretics in the treatment of hypertension. American heart journal, 1973, Volume: 85, Issue:1 Topics: Adult; Body Weight; Clinical Trials as Topic; Diet, Sodium-Restricted; Female; Humans; Hydrochloroth	1973
Biochemical observations during a trial of inosiplex in senile dementia. Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:8 Topics: Aged; Amino Alcohols; Benzoates; Body Weight; Clinical Trials as Topic; Dementia; Humans; Hypoxanthi	1973
Effect of alprenolol and alprenolol in combination with saluretics in hypertension. Acta medica Scandinavica. Supplementum, 1974, Volume: 554 Topics: Adult; Aged; Alprenolol; Benzothiadiazines; Blood Pressure; Body Weight; Clinical Trials as Topic; D	1974
Long-term effect of alprenolol as antihypertensive agent. Acta medica Scandinavica. Supplementum, 1974, Volume: 554 Topics: Adult; Airway Obstruction; Alprenolol; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials	1974
Xipamid in the treatment of oedema in rheumatoid arthritis. Rheumatology and rehabilitation, 1974, Volume: 13, Issue:2 Topics: Aged; Arthritis, Rheumatoid; Body Weight; Clinical Trials as Topic; Diuretics; Edema; Female; Furose	1974
Clinical evaluation of tibric acid (CP 18,524) a new hypolipidemic agent. Pharmacological research communications, 1974, Volume: 6, Issue:5 Topics: Adult; Aged; Benzoates; Body Weight; Cholesterol; Clinical Trials as Topic; Coronary Disease; Female	1974
Renal function following methoxyflurane anaesthesia. British journal of anaesthesia, 1973, Volume: 45, Issue:4 Topics: Adolescent; Anesthesia, Inhalation; Body Weight; Child; Creatinine; Female; Halothane; Humans; Kidne	1973
[Saluretic treatment of hypertension and uric acid level in serum. Clinical test of a combination of hydrochlorothiazide and probenecid]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:11 Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Blood Protein Electrophoresis; Bod	1969
Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA, 1970, Aug-17, Volume: 213, Issue:7 Topics: Adult; Age Factors; Antihypertensive Agents; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Bod	1970
Hypotensive effects of clonidine and chlorthalidone. Controlled clinical trial of drugs administered singly and in combination. American heart journal, 1971, Volume: 82, Issue:3 Topics: Alkaline Phosphatase; Antihypertensive Agents; Aspartate Aminotransferases; Bilirubin; Blood Glucose	1971
Antihypertensive properties of cryptenamine used with reserpine and methyclothiazide. Journal of pharmaceutical sciences, 1971, Volume: 60, Issue:8 Topics: Adult; Aged; Anorexia Nervosa; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight;	1971
Renal dysfunction associated with methoxyflurane anesthesia. A randomized, prospective clinical evaluation. JAMA, 1971, Apr-12, Volume: 216, Issue:2 Topics: Adult; Aged; Anesthetics; Blood Urea Nitrogen; Body Weight; Creatinine; Halothane; Humans; Hypernatr	1971
Refractory obesity and diabetes. Annals of the New York Academy of Sciences, 1968, Mar-26, Volume: 148, Issue:3 Topics: Adult; Body Weight; Diabetes Mellitus; Diet, Diabetic; Fasting; Female; Glucose Tolerance Test; Huma	1968
Metabolic and hypotensive effects of ethacrynic acid. Comparative study with hydrochlorothiazide. JAMA, 1968, Jul-01, Volume: 205, Issue:1 Topics: Analysis of Variance; Aspartate Aminotransferases; Blood Glucose; Blood Pressure; Blood Urea Nitroge	1968
[Effect of ketogenic diet on body weight, intermediary and electrolyte metabolism of obese subjects]. Deutsche medizinische Wochenschrift (1946), 1969, Volume: 94, Issue:2 Topics: Adult; Body Weight; Carbon Dioxide; Creatinine; Diet, Reducing; Diet, Sodium-Restricted; Female; Hum	1969
Long-term effect of probenecid on diuretic-induced hyperuricemia. JAMA, 1966, Oct-10, Volume: 198, Issue:2 Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure Determination; Body Weight; Chlorthalidone; Hum	1966

uric acid and Body Weight