uric acid has been researched along with Bipolar Disorder in 33 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous research has hypothesised increased uric acid levels, possibly because of an amplified purinergic metabolism and a reduced adenosine activity, in subjects with bipolar disorder." | 8.93 | Uric acid levels in subjects with bipolar disorder: A comparative meta-analysis. ( Bartoli, F; Carrà, G; Clerici, M; Crocamo, C; Mazza, MG, 2016) |
| "We aimed to investigate the difference in serum uric acid(SUA)levels between subtypes of depression and normal population, and whether SUA can be used to identify bipolar disorder depressive episode and major depressive disorder and predict the length of hospital stay." | 7.96 | Serum uric acid a depression biomarker. ( Deng, W; Huang, X; Li, J; Li, T; Meng, X, 2020) |
| "Uric acid (UA) has been suggested as a possible biomarker of bipolar disorder (BD) in recent studies." | 7.96 | Comparison of Serum Uric Acid in Major Depressive Disorder and Bipolar Disorder: a Retrospective Chart Review Study. ( Ahn, YM; Kim, S; Rhee, SJ; Song, Y, 2020) |
| " Bipolar disorder was the only diagnostic subgroup significantly associated with increased uric acid levels." | 7.83 | Exploring the association between bipolar disorder and uric acid: A mediation analysis. ( Bartoli, F; Carrà, G; Castagna, G; Clerici, M; Crocamo, C; Gennaro, GM; Trotta, G, 2016) |
| "The aim of this study was to investigate whether uric acid levels are different between patients with remission period of bipolar disorder type I (BD) and patients with remission period of major depressive disorder (MDD)." | 7.80 | Uric acid levels may be a biological marker for the differentiation of unipolar and bipolar disorder: the role of affective temperament. ( Gültekin, BK; Kesebir, S; Süner, O; Tatlıdil Yaylacı, E, 2014) |
| "The uric acid(UA) level was measured using automatic biochemical analyzer, and cognitive function was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Stroop color-word test." | 5.91 | Association between uric acid and cognitive dysfunction: A cross-sectional study with newly diagnosed, drug-naïve with bipolar disorder. ( Chen, J; Li, S; Lu, X; Qiu, Y; Tang, H; Teng, Z; Wang, B; Wu, H; Xiang, H; Xu, X; Zhao, Z, 2023) |
| " In parallel, adenosine deficit is increasingly recognized in epilepsy pathophysiology." | 5.41 | Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence. ( Boison, D; Daniels, SD, 2023) |
| "Uric acid is a key nitrogenous end product of purine metabolism." | 5.36 | Increased uric acid levels in drug-naïve subjects with bipolar disorder during a first manic episode. ( Luckenbaugh, DA; Machado-Vieira, R; Portela, LV; Salvadore, G; Souza, DO; Viale, CI; Zanatto, VC; Zarate, CA, 2010) |
| " Patients treated with olanzapine, however, had significantly greater weight gain and increases in the levels of hepatic enzymes, prolactin, fasting glucose, fasting total cholesterol, and uric acid." | 5.12 | Olanzapine versus placebo in the treatment of adolescents with bipolar mania. ( Biederman, J; Carlson, G; Delbello, M; Dittmann, RW; Findling, R; Kowatch, R; Kryzhanovskaya, L; Lin, D; Robertson-Plouch, C; Tohen, M; Wagner, K; Wozniak, J; Xu, W, 2007) |
| "Previous research has hypothesised increased uric acid levels, possibly because of an amplified purinergic metabolism and a reduced adenosine activity, in subjects with bipolar disorder." | 4.93 | Uric acid levels in subjects with bipolar disorder: A comparative meta-analysis. ( Bartoli, F; Carrà, G; Clerici, M; Crocamo, C; Mazza, MG, 2016) |
| "We aimed to investigate the difference in serum uric acid(SUA)levels between subtypes of depression and normal population, and whether SUA can be used to identify bipolar disorder depressive episode and major depressive disorder and predict the length of hospital stay." | 3.96 | Serum uric acid a depression biomarker. ( Deng, W; Huang, X; Li, J; Li, T; Meng, X, 2020) |
| "Uric acid (UA) has been suggested as a possible biomarker of bipolar disorder (BD) in recent studies." | 3.96 | Comparison of Serum Uric Acid in Major Depressive Disorder and Bipolar Disorder: a Retrospective Chart Review Study. ( Ahn, YM; Kim, S; Rhee, SJ; Song, Y, 2020) |
| "Bipolar disorder (BD) patients have increased serum Uric Acid (UA) levels as compared to their healthy counterparts." | 3.88 | Serum uric acid levels in first episode mania, effect on clinical presentation and treatment response: Data from a case control study. ( Chatterjee, SS; Ghosal, MK; Ghosal, S; Mallik, N; Mitra, S, 2018) |
| " Hyperuricemia was determined as serum uric acid level above 420 μmol/L in men and 360 μmol/L in women (N Engl J Med 359(17):1811-1821, 2008)." | 3.88 | Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder. ( Chen, H; Chen, J; Feng, J; Huang, XF; Jones, A; Li, J; Li, R; Tan, Y; Wang, S; Wilson, I; Yang, F; Zhang, L, 2018) |
| "This study aimed to a) examine IR and β-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and β cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or without MetS and TUD, versus 46 healthy controls, and b) whether IR is associated with IO&NS biomarkers, including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), plasma advanced oxidation protein products (AOPP), C-reactive protein (CRP), haptoglobin (Hp) and uric acid." | 3.85 | Indices of insulin resistance and glucotoxicity are not associated with bipolar disorder or major depressive disorder, but are differently associated with inflammatory, oxidative and nitrosative biomarkers. ( Berk, M; Camargo, AEI; de Farias, CC; Dodd, S; Favaro Soares, J; Gastaldello Moreira, E; Higachi, L; Landucci Bonifácio, K; Maes, M; Nunes, SOV; Odebrecht Vargas, H; Sabbatini Barbosa, D, 2017) |
| "Findings of this study add evidence to the role of uric acid as state, rather than trait, marker in bipolar disorders." | 3.85 | Purinergic system dysfunctions in subjects with bipolar disorder: A comparative cross-sectional study. ( Bartoli, F; Brosio, E; Capuzzi, E; Carrà, G; Clerici, M; Crocamo, C; Dakanalis, A; Miotto, A, 2017) |
| " Bipolar disorder was the only diagnostic subgroup significantly associated with increased uric acid levels." | 3.83 | Exploring the association between bipolar disorder and uric acid: A mediation analysis. ( Bartoli, F; Carrà, G; Castagna, G; Clerici, M; Crocamo, C; Gennaro, GM; Trotta, G, 2016) |
| "This study examines the effects of malondialdehyde (MDA) and uric acid on insulin resistance and atherogenicity in subjects with and without mood disorders, the metabolic syndrome (MetS) and tobacco use disorder (TUD)." | 3.81 | Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder. ( Barbosa, DS; Berk, M; Bortolasci, CC; de Castro, MR; de Melo, LG; Dodd, S; Maes, M; Moreira, EG; Vargas Nunes, SO; Vargas, HO, 2015) |
| "The aim of this study was to investigate whether uric acid levels are different between patients with remission period of bipolar disorder type I (BD) and patients with remission period of major depressive disorder (MDD)." | 3.80 | Uric acid levels may be a biological marker for the differentiation of unipolar and bipolar disorder: the role of affective temperament. ( Gültekin, BK; Kesebir, S; Süner, O; Tatlıdil Yaylacı, E, 2014) |
| "The uric acid(UA) level was measured using automatic biochemical analyzer, and cognitive function was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Stroop color-word test." | 1.91 | Association between uric acid and cognitive dysfunction: A cross-sectional study with newly diagnosed, drug-naïve with bipolar disorder. ( Chen, J; Li, S; Lu, X; Qiu, Y; Tang, H; Teng, Z; Wang, B; Wu, H; Xiang, H; Xu, X; Zhao, Z, 2023) |
| "Uric acid is a key nitrogenous end product of purine metabolism." | 1.36 | Increased uric acid levels in drug-naïve subjects with bipolar disorder during a first manic episode. ( Luckenbaugh, DA; Machado-Vieira, R; Portela, LV; Salvadore, G; Souza, DO; Viale, CI; Zanatto, VC; Zarate, CA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 18 (54.55) | 24.3611 |
| 2020's | 9 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Z | 1 |
| Wang, Y | 1 |
| Xun, G | 1 |
| Malewska-Kasprzak, M | 1 |
| Permoda, A | 1 |
| Rybakowski, JK | 1 |
| Zhu, Y | 1 |
| Wu, X | 1 |
| Liu, H | 1 |
| Niu, Z | 1 |
| Zhao, J | 1 |
| Wang, F | 1 |
| Mao, R | 1 |
| Guo, X | 1 |
| Zhang, C | 1 |
| Wang, Z | 1 |
| Chen, J | 3 |
| Fang, Y | 1 |
| Jiménez-Fernández, S | 1 |
| Gurpegui, M | 1 |
| Garrote-Rojas, D | 1 |
| Gutiérrez-Rojas, L | 1 |
| Carretero, MD | 1 |
| Correll, CU | 1 |
| Li, S | 1 |
| Lu, X | 1 |
| Qiu, Y | 1 |
| Teng, Z | 1 |
| Zhao, Z | 1 |
| Xu, X | 1 |
| Tang, H | 1 |
| Xiang, H | 1 |
| Wang, B | 1 |
| Wu, H | 1 |
| Daniels, SD | 1 |
| Boison, D | 1 |
| Meng, X | 1 |
| Huang, X | 1 |
| Deng, W | 1 |
| Li, J | 2 |
| Li, T | 1 |
| Kim, S | 1 |
| Rhee, SJ | 1 |
| Song, Y | 1 |
| Ahn, YM | 1 |
| Landucci Bonifácio, K | 1 |
| Sabbatini Barbosa, D | 1 |
| Gastaldello Moreira, E | 1 |
| de Farias, CC | 1 |
| Higachi, L | 1 |
| Camargo, AEI | 1 |
| Favaro Soares, J | 1 |
| Odebrecht Vargas, H | 1 |
| Nunes, SOV | 1 |
| Berk, M | 2 |
| Dodd, S | 2 |
| Maes, M | 2 |
| Chatterjee, SS | 1 |
| Ghosal, S | 1 |
| Mitra, S | 1 |
| Mallik, N | 1 |
| Ghosal, MK | 1 |
| Dos Santos Oliveira, PM | 1 |
| Santos, V | 1 |
| Coroa, M | 1 |
| Ribeiro, J | 1 |
| Madeira, N | 1 |
| Chen, H | 1 |
| Feng, J | 1 |
| Zhang, L | 1 |
| Li, R | 1 |
| Wang, S | 1 |
| Wilson, I | 1 |
| Jones, A | 1 |
| Tan, Y | 1 |
| Yang, F | 1 |
| Huang, XF | 1 |
| Bartoli, F | 6 |
| Crocamo, C | 4 |
| Carrà, G | 6 |
| Tatay-Manteiga, A | 1 |
| Balanzá-Martínez, V | 1 |
| Bristot, G | 1 |
| Tabarés-Seisdedos, R | 1 |
| Kapczinski, F | 4 |
| Cauli, O | 1 |
| Wiener, C | 1 |
| Rassier, GT | 1 |
| Kaster, MP | 1 |
| Jansen, K | 1 |
| Pinheiro, RT | 1 |
| Klamt, F | 1 |
| Magalhães, PV | 1 |
| Ghisleni, G | 1 |
| da Silva, RA | 1 |
| Kesebir, S | 1 |
| Tatlıdil Yaylacı, E | 1 |
| Süner, O | 1 |
| Gültekin, BK | 1 |
| Albert, U | 1 |
| De Cori, D | 1 |
| Aguglia, A | 1 |
| Barbaro, F | 1 |
| Bogetto, F | 1 |
| Maina, G | 1 |
| Muti, M | 1 |
| Del Grande, C | 1 |
| Musetti, L | 1 |
| Marazziti, D | 1 |
| Turri, M | 1 |
| Cirronis, M | 1 |
| Pergentini, I | 1 |
| Corsi, M | 1 |
| Dell'Osso, L | 1 |
| Corsini, GU | 1 |
| Bortolasci, CC | 1 |
| Vargas, HO | 1 |
| Vargas Nunes, SO | 1 |
| de Melo, LG | 1 |
| de Castro, MR | 1 |
| Moreira, EG | 1 |
| Barbosa, DS | 1 |
| Gennaro, GM | 1 |
| Castagna, G | 1 |
| Trotta, G | 1 |
| Clerici, M | 5 |
| Mazza, MG | 1 |
| Dakanalis, A | 1 |
| Brosio, E | 1 |
| Miotto, A | 1 |
| Capuzzi, E | 1 |
| Machado-Vieira, R | 5 |
| Salem, H | 1 |
| Frey, BN | 1 |
| Barbosa, IG | 1 |
| Teixeira, AL | 1 |
| Salvadore, G | 1 |
| Viale, CI | 1 |
| Luckenbaugh, DA | 1 |
| Zanatto, VC | 1 |
| Portela, LV | 1 |
| Souza, DO | 3 |
| Zarate, CA | 1 |
| Tohen, M | 1 |
| Kryzhanovskaya, L | 1 |
| Carlson, G | 1 |
| Delbello, M | 1 |
| Wozniak, J | 1 |
| Kowatch, R | 1 |
| Wagner, K | 1 |
| Findling, R | 1 |
| Lin, D | 1 |
| Robertson-Plouch, C | 1 |
| Xu, W | 1 |
| Dittmann, RW | 1 |
| Biederman, J | 1 |
| Lara, DR | 2 |
| Brooks, SC | 1 |
| Linn, JJ | 1 |
| Disney, N | 1 |
| Anumonye, A | 1 |
| Reading, HW | 2 |
| Knight, F | 1 |
| Ashcroft, GW | 1 |
| Dewar, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder[NCT00050206] | Phase 4 | 130 participants | Interventional | 2002-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for uric acid and Bipolar Disorder
| Article | Year |
|---|---|
Oxidative stress parameters and antioxidants in adults with unipolar or bipolar depression versus healthy controls: Systematic review and meta-analysis.
Topics: Adult; Antioxidants; Biomarkers; Bipolar Disorder; Catalase; Depression; Glutathione Peroxidase; Hum | 2022 |
Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence.
Topics: Adenosine; Adenosine Triphosphate; Antimanic Agents; Bipolar Disorder; Epilepsy; Humans; Hydrocortis | 2023 |
Uric acid levels in subjects with bipolar disorder: A comparative meta-analysis.
Topics: Bipolar Disorder; Databases, Bibliographic; Humans; Uric Acid | 2016 |
1 trial available for uric acid and Bipolar Disorder
| Article | Year |
|---|---|
Olanzapine versus placebo in the treatment of adolescents with bipolar mania.
Topics: Adolescent; Age Factors; Alanine Transaminase; Antipsychotic Agents; Aspartate Aminotransferases; Be | 2007 |
29 other studies available for uric acid and Bipolar Disorder
| Article | Year |
|---|---|
Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case-control study.
Topics: Adult; Antidepressive Agents; Biomarkers; Bipolar Disorder; Case-Control Studies; Depressive Disorde | 2021 |
Dysfunction of the Purinergic System in Bipolar Disorder.
Topics: Bipolar Disorder; Female; Humans; Male; Mania; Uric Acid | 2022 |
Employing biochemical biomarkers for building decision tree models to predict bipolar disorder from major depressive disorder.
Topics: Bilirubin; Biomarkers; Bipolar Disorder; Decision Trees; Depressive Disorder, Major; Female; Humans; | 2022 |
Association between uric acid and cognitive dysfunction: A cross-sectional study with newly diagnosed, drug-naïve with bipolar disorder.
Topics: Bipolar Disorder; Cognition Disorders; Cognitive Dysfunction; Cross-Sectional Studies; Female; Human | 2023 |
Serum uric acid a depression biomarker.
Topics: Adolescent; Adult; Aged; Biomarkers; Bipolar Disorder; Case-Control Studies; China; Depression; Depr | 2020 |
Comparison of Serum Uric Acid in Major Depressive Disorder and Bipolar Disorder: a Retrospective Chart Review Study.
Topics: Adult; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Biomarkers; Bipolar Disorder; | 2020 |
Indices of insulin resistance and glucotoxicity are not associated with bipolar disorder or major depressive disorder, but are differently associated with inflammatory, oxidative and nitrosative biomarkers.
Topics: Adult; Biomarkers; Bipolar Disorder; Blood Glucose; Body Mass Index; C-Reactive Protein; Cross-Secti | 2017 |
Serum uric acid levels in first episode mania, effect on clinical presentation and treatment response: Data from a case control study.
Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Female; Humans; Male; Middle Aged; Prognosis; | 2018 |
Serum uric acid as a predictor of bipolarity in individuals with a major depressive episode.
Topics: Adult; Biomarkers; Bipolar Disorder; Cyclothymic Disorder; Depressive Disorder, Major; Female; Human | 2019 |
Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder.
Topics: Adult; Bipolar Disorder; China; Comorbidity; Correlation of Data; Diagnostic and Statistical Manual | 2018 |
Differences in serum uric acid between 'unipolar' and 'bipolar' depression: Preliminary data.
Topics: Bipolar Disorder; Depression; Depressive Disorder, Major; Humans; Preliminary Data; Uric Acid | 2019 |
Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and in Siblings.
Topics: Adult; Antimanic Agents; Biomarkers; Bipolar Disorder; Case-Control Studies; Cross-Sectional Studies | 2020 |
Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes.
Topics: Adolescent; Adult; Advanced Oxidation Protein Products; Bipolar Disorder; Brazil; Case-Control Studi | 2014 |
Uric acid levels may be a biological marker for the differentiation of unipolar and bipolar disorder: the role of affective temperament.
Topics: Adult; Biomarkers; Bipolar Disorder; Depressive Disorder; Diagnosis, Differential; Female; Humans; M | 2014 |
Increased uric acid levels in bipolar disorder subjects during different phases of illness.
Topics: Adult; Biomarkers; Bipolar Disorder; Cyclothymic Disorder; Diagnostic and Statistical Manual of Ment | 2015 |
Serum uric acid levels and different phases of illness in bipolar I patients treated with lithium.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Carbamazepine; Drug Therapy, Combination; Female; Humans; | 2015 |
Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder.
Topics: Adolescent; Adult; Aged; Atherosclerosis; Biomarkers; Bipolar Disorder; Blood Glucose; Body Mass Ind | 2015 |
Exploring the association between bipolar disorder and uric acid: A mediation analysis.
Topics: Adult; Bipolar Disorder; Cross-Sectional Studies; Female; Humans; Male; Metabolic Syndrome; Middle A | 2016 |
Purinergic system dysfunctions in subjects with bipolar disorder: A comparative cross-sectional study.
Topics: Adolescent; Adult; Aged; Bilirubin; Biomarkers; Bipolar Disorder; Case-Control Studies; Creatinine; | 2017 |
Update on bipolar disorder biomarker candidates: what about uric acid/adenosine hypothesis?
Topics: Adenosine; Biomarkers; Bipolar Disorder; Humans; Uric Acid | 2017 |
Convergent lines of evidence support the role of uric acid levels as a potential biomarker in bipolar disorder.
Topics: Biomarkers; Bipolar Disorder; Humans; Uric Acid | 2017 |
Purinergic dysfunction in bipolar disorder: Any role for the antioxidant uric acid as a trait and state biomarker?
Topics: Antioxidants; Biomarkers; Bipolar Disorder; Humans; Purines; Uric Acid | 2017 |
Increased uric acid levels in drug-naïve subjects with bipolar disorder during a first manic episode.
Topics: Analysis of Variance; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Femal | 2010 |
Purinergic system in the treatment of bipolar disorder: uric acid levels as a screening test in mania.
Topics: Allopurinol; Antimanic Agents; Bipolar Disorder; Diagnostic Tests, Routine; Humans; Mass Screening; | 2012 |
Therapeutic efficacy of allopurinol in mania associated with hyperuricemia.
Topics: Adult; Allopurinol; Bipolar Disorder; Enzyme Inhibitors; Female; Humans; Male; Treatment Outcome; Ur | 2001 |
Purinergic dysfunction in mania: an integrative model.
Topics: Adenosine; Adenosine Triphosphate; Animals; Anticonvulsants; Antimanic Agents; Behavior; Bipolar Dis | 2002 |
Serotonin, folic acid, and uric acid metabolism in the diagnosis of neuropsychiatric disorders.
Topics: Adolescent; Adult; Bipolar Disorder; Brain; Carbolines; Female; Folic Acid; Hallucinations; Humans; | 1978 |
Uric-acid metabolism in manic-depressive illness and during lithium therapy.
Topics: Adult; Aged; Bipolar Disorder; Brain; Female; Humans; Kidney; Lithium; Male; Middle Aged; Uric Acid | 1968 |
Effect of lithinum administration on RNA metabolism in rat brain.
Topics: Animals; Bipolar Disorder; Brain; Carbon Isotopes; Humans; Injections, Intraperitoneal; Lithium; Liv | 1971 |