Page last updated: 2024-10-20

uric acid and Autoimmune Disease

uric acid has been researched along with Autoimmune Disease in 22 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
" The objective is to determine whether therapy with TNF inhibitors (TNFis) affects SUA levels in patients with systemic autoimmune rheumatic diseases (SARDs) and whether SUA changes correlate with pro-inflammatory cytokines or with the oxidative stress marker allantoin."7.91Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors. ( Hasikova, L; Herrmann, M; Hulejova, H; Kalikova, K; Kozlik, P; Mahajan, A; Pavlikova, M; Stiburkova, B; Zavada, J, 2019)
"To quantify serum uric acid (UA) levels in autoimmune myelopathy (AMs) patients and analyze the clinical relevance."7.81[Serum uric acid level and clinical relevance analysis in autoimmune myelopathy]. ( Jiao, J; Jiao, Y; Zhang, J; Zhang, W, 2015)
"Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine."7.73[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout]. ( Anan'eva, MN; Dubiaga, VV; Nikolenko, IuI; Nikolenko, VIu; Shchukin, IN; Siniachenko, OV, 2005)
"In patients with healthy native kidneys, long-term cyclosporine therapy, even at a low dose (5 mg/kg per day), is nephrotoxic and is associated with a high incidence of hypertension."7.68Renal function and blood pressure in patients receiving long-term, low-dose cyclosporine therapy for idiopathic autoimmune uveitis. ( Aupetit, B; Baumelou, A; Benhmida, M; Deray, G; Jacobs, C; Le Hoang, P; Maksud, P, 1992)
" The objective is to determine whether therapy with TNF inhibitors (TNFis) affects SUA levels in patients with systemic autoimmune rheumatic diseases (SARDs) and whether SUA changes correlate with pro-inflammatory cytokines or with the oxidative stress marker allantoin."3.91Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors. ( Hasikova, L; Herrmann, M; Hulejova, H; Kalikova, K; Kozlik, P; Mahajan, A; Pavlikova, M; Stiburkova, B; Zavada, J, 2019)
"To quantify serum uric acid (UA) levels in autoimmune myelopathy (AMs) patients and analyze the clinical relevance."3.81[Serum uric acid level and clinical relevance analysis in autoimmune myelopathy]. ( Jiao, J; Jiao, Y; Zhang, J; Zhang, W, 2015)
"Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine."3.73[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout]. ( Anan'eva, MN; Dubiaga, VV; Nikolenko, IuI; Nikolenko, VIu; Shchukin, IN; Siniachenko, OV, 2005)
"In patients with healthy native kidneys, long-term cyclosporine therapy, even at a low dose (5 mg/kg per day), is nephrotoxic and is associated with a high incidence of hypertension."3.68Renal function and blood pressure in patients receiving long-term, low-dose cyclosporine therapy for idiopathic autoimmune uveitis. ( Aupetit, B; Baumelou, A; Benhmida, M; Deray, G; Jacobs, C; Le Hoang, P; Maksud, P, 1992)
"Antioxidants (ascorbic acid, glutathione, cysteine, alpha-tocopherol) and uric acid were measured using two high-pressure liquid chromatographic methods in 3 regions (cervical, thoracic, lumbar) of the spinal cord and in blood of Lewis rats during the attack and recovery of experimental autoimmune encephalomyelitis (EAE)."3.67Measurement of free radical scavengers in the spinal cord of rats with experimental autoimmune encephalomyelitis. ( Honegger, CG; Krenger, W; Langemann, H, 1989)
"Hypothyroidism is a frequently diagnosed endocrine disorder that has characteristic clinical signs and symptoms."2.37Unusual manifestations of hypothyroidism. ( Klein, I; Levey, GS, 1984)
" A comparison of baseline blood metabolites with those obtained after the full Cy dosage (day 0) revealed a significant increase in blood glucose and uric acid levels with an associated decrease in serum calcium, sodium, and potassium levels."1.91Serum Electrolyte and Metabolic Changes During Conditioning of Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases: A Prospective Study in a Single Institution. ( Gallardo-Pérez, MM; Méndez-Laureano, BJ; Minutti-Zanella, C; Ruiz-Argüelles, GJ, 2023)
"Patients without pneumonitis had a significantly higher RVSP value than those with pneumonitis (77."1.33Pulmonary arterial hypertension in autoimmune diseases: an analysis of 19 cases from a medical center in northern Taiwan. ( Chen, CH; Chen, HA; Chou, CT; Huang, DF; Liao, HT; Wang, HP, 2006)
" This study describes the observed adverse reactions in this group of patients not undergoing transplantation."1.27Side effects of systemic cyclosporine in patients not undergoing transplantation. ( Chan, CC; Nussenblatt, RB; Palestine, AG, 1984)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19909 (40.91)18.7374
1990's1 (4.55)18.2507
2000's5 (22.73)29.6817
2010's3 (13.64)24.3611
2020's4 (18.18)2.80

Authors

AuthorsStudies
Kang, Y1
Yang, Z1
Wang, T1
Chen, X1
Zhang, Q1
Xie, Q1
Wang, M1
Méndez-Laureano, BJ1
Gallardo-Pérez, MM1
Minutti-Zanella, C1
Ruiz-Argüelles, GJ1
Duhalde Vega, M1
Aparicio, JL1
Mandour, MF1
Retegui, LA1
Wang, B1
Chen, S1
Qian, H1
Zheng, Q1
Chen, R1
Liu, Y1
Shi, G1
Li, X1
Meng, X1
Spiliopoulou, A1
Timofeeva, M1
Wei, WQ1
Gifford, A1
Shen, X1
He, Y1
Varley, T1
McKeigue, P1
Tzoulaki, I1
Wright, AF1
Joshi, P1
Denny, JC1
Campbell, H1
Theodoratou, E1
Hasikova, L1
Pavlikova, M1
Hulejova, H1
Kozlik, P1
Kalikova, K1
Mahajan, A1
Herrmann, M1
Stiburkova, B1
Zavada, J1
Zhang, W1
Zhang, J1
Jiao, Y1
Jiao, J1
Orsoni, JG1
Zavota, L1
Mora, P1
Rubino, P1
Manzotti, F1
Pellistri, I1
Abrams, B1
Martinon, F1
Mayor, A1
Tschopp, J1
Nikolenko, IuI1
Siniachenko, OV1
Anan'eva, MN1
Nikolenko, VIu1
Dubiaga, VV1
Shchukin, IN1
Chen, CH1
Chen, HA1
Wang, HP1
Liao, HT1
Chou, CT1
Huang, DF1
Schattenkirchner, M1
Klein, I1
Levey, GS1
Palestine, AG1
Nussenblatt, RB1
Chan, CC1
Turner, RA1
Pisko, EJ1
Agudelo, CA1
Counts, GB1
Foster, SL1
Treadway, WJ1
Deray, G1
Benhmida, M1
Le Hoang, P1
Maksud, P1
Aupetit, B1
Baumelou, A1
Jacobs, C1
Honegger, CG1
Krenger, W1
Langemann, H1
Brittinger, G1
Christian, CL1
Butler, VP1
Hamerman, D1
Krane, SM1
Larson, CB1
Malawista, SE1
Mikkelsen, WM1
Pearson, CM1
Symthe, HA1
Taranta, A1
Tomasi, TB1
Ward, LE1
Weinberger, HJ1
Glynn, LE1
Masszi, J1
Horváth, A1
Mecher, T1
Kulcsár, G1

Reviews

5 reviews available for uric acid and Autoimmune Disease

ArticleYear
Role of T cells in the pathogenesis and treatment of gout.
    International immunopharmacology, 2020, Volume: 88

    Topics: Animals; Arthritis, Gouty; Autoimmune Diseases; Cytokines; Humans; Inflammasomes; T-Lymphocyte Subse

2020
The inflammasomes: guardians of the body.
    Annual review of immunology, 2009, Volume: 27

    Topics: Animals; Autoimmune Diseases; Carrier Proteins; Humans; Immunity, Innate; Inflammation; Interleukin-

2009
Unusual manifestations of hypothyroidism.
    Archives of internal medicine, 1984, Volume: 144, Issue:1

    Topics: Adult; Anemia; Arthritis, Rheumatoid; Autoimmune Diseases; Cardiomegaly; Electromyography; Female; H

1984
[Non-specific basic therapy of leukemias and their complications].
    Medizinische Klinik, 1974, Aug-23, Volume: 69, Issue:34

    Topics: Acute Disease; Adrenal Cortex Hormones; Allopurinol; Anemia; Autoimmune Diseases; Blood Coagulation

1974
Eighteenth rheumatism review. Review of American and English literature for the years 1965 and 1966.
    Arthritis and rheumatism, 1968, Volume: 11, Issue:3

    Topics: Adult; Animals; Arthritis, Infectious; Arthritis, Rheumatoid; Autoimmune Diseases; Bone Diseases; Ca

1968

Other Studies

17 other studies available for uric acid and Autoimmune Disease

ArticleYear
Impact of serum uric acid on left ventricular diastolic function in patients with autoimmune diseases.
    Chinese medical journal, 2022, 08-05, Volume: 135, Issue:15

    Topics: Autoimmune Diseases; Diastole; Humans; Uric Acid; Ventricular Dysfunction, Left; Ventricular Functio

2022
Serum Electrolyte and Metabolic Changes During Conditioning of Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases: A Prospective Study in a Single Institution.
    Hematology/oncology and stem cell therapy, 2023, Jul-20, Volume: 17, Issue:1

    Topics: Adult; Aged; Autoimmune Diseases; Blood Glucose; Creatinine; Cyclophosphamide; Hematopoietic Stem Ce

2023
The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO).
    Immunology letters, 2020, Volume: 217

    Topics: Alarmins; Animals; Autoantibodies; Autoimmune Diseases; Autoimmunity; Coronavirus Infections; Female

2020
MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.
    Annals of the rheumatic diseases, 2018, Volume: 77, Issue:7

    Topics: Adult; Arthritis; Autoimmune Diseases; Biological Specimen Banks; Celiac Disease; Female; Genetic Pr

2018
Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors.
    Rheumatology international, 2019, Volume: 39, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allantoin; Antirheumatic Agents; Autoimmune Diseases; Bi

2019
[Serum uric acid level and clinical relevance analysis in autoimmune myelopathy].
    Zhonghua yi xue za zhi, 2015, Mar-10, Volume: 95, Issue:9

    Topics: Autoimmune Diseases; Biomarkers; Female; Humans; Magnetic Resonance Imaging; Male; Oximes; Spinal Co

2015
Discontinuous drug combination therapy in autoimmune ocular disorders.
    Acta ophthalmologica, 2009, Volume: 87, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Blood Pressure; Drug Resistance; Dr

2009
How gout inhibits the development of cell-mediated autoimmune disease.
    Medical hypotheses, 2009, Volume: 72, Issue:1

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Gout; Humans; Immunity, Cellular; Uric Acid

2009
[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout].
    Likars'ka sprava, 2005, Issue:4

    Topics: Amino Acids; Autoimmune Diseases; Gout; Humans; Hyperuricemia; Lipid Peroxides; Purines; Uric Acid;

2005
Pulmonary arterial hypertension in autoimmune diseases: an analysis of 19 cases from a medical center in northern Taiwan.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2006, Volume: 39, Issue:2

    Topics: Adult; Aged; Antibodies, Antinuclear; Autoimmune Diseases; Female; Hospitals; Humans; Hypergammaglob

2006
[Pathogenetic mechanisms in joint diseases].
    Medizinische Klinik, 1981, May-08, Volume: 76, Issue:10

    Topics: Arthritis; Arthritis, Infectious; Arthritis, Reactive; Autoimmune Diseases; Chondrocalcinosis; Cryst

1981
Side effects of systemic cyclosporine in patients not undergoing transplantation.
    The American journal of medicine, 1984, Volume: 77, Issue:4

    Topics: Adolescent; Adult; Aged; Anemia; Autoimmune Diseases; Blood Sedimentation; Chemical and Drug Induced

1984
Uric acid effects on in vitro models of rheumatoid inflammatory and autoimmune processes.
    Annals of the rheumatic diseases, 1983, Volume: 42, Issue:3

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Cells, Cultured; Glucuronidase; Humans; Immunoglobulin G

1983
Renal function and blood pressure in patients receiving long-term, low-dose cyclosporine therapy for idiopathic autoimmune uveitis.
    Annals of internal medicine, 1992, Oct-01, Volume: 117, Issue:7

    Topics: Adult; Autoimmune Diseases; Cholesterol; Creatinine; Cyclosporine; Drug Administration Schedule; Fem

1992
Measurement of free radical scavengers in the spinal cord of rats with experimental autoimmune encephalomyelitis.
    Neuroscience letters, 1989, Apr-10, Volume: 98, Issue:3

    Topics: Animals; Antioxidants; Ascorbic Acid; Autoimmune Diseases; Cysteine; Encephalomyelitis; Free Radical

1989
The chronicity of inflammation and its significance in rheumatoid arthritis.
    Annals of the rheumatic diseases, 1968, Volume: 27, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Antibodies; Antigens; Arthritis, Rheumatoid; Autoimmune Diseases; C

1968
[Significance of hyperuricacidemia in psoriasis vulgaris and some other dermatoses].
    Dermatologische Monatschrift, 1972, Volume: 158, Issue:4

    Topics: Adolescent; Adult; Aged; Autoimmune Diseases; Clinical Enzyme Tests; Female; Gout; Humans; Hypersens

1972