uric acid has been researched along with Autoimmune Diabetes in 113 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The following factors were selected in the stepwise multivariate model as predictors of micro- or macroalbuminuria at the 6-year follow-up visit: baseline serum uric acid levels, HbA(1c) and pre-albuminuria." | 7.76 | Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study. ( Jalal, DI; Johnson, RJ; Maahs, DM; McFann, K; Rewers, M; Rivard, CJ; Snell-Bergeon, JK, 2010) |
| "The relationship between elevated serum uric acid (SUA) and coronary heart disease (CHD) is discussed controversially." | 7.68 | Association of elevated serum uric acid with coronary heart disease in diabetes mellitus. ( Dannehl, K; Gries, FA; Hauner, H; Rathmann, W, 1993) |
| "Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults." | 5.40 | Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. ( Bjornstad, P; Chonchol, MB; Jalal, D; Johnson, RJ; Maahs, DM; McFann, K; Paul Wadwa, R; Rewers, M; Rivard, CJ; Sirota, JC; Snell-Bergeon, JK, 2014) |
| "As the KL-VS haplotype alters secretion and activity of KLOTHO and uric acid (UA) is associated with endothelial dysfunction and inflammation, their mutual links may contribute to microalbuminuria (MA) in patients with type 1 diabetes (T1D)." | 3.96 | A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents. ( Gabig-Cimińska, M; Myśliwiec, M; Ryba-Stanisławowska, M; Skrzypkowska, M; Słomiński, B, 2020) |
| "The following factors were selected in the stepwise multivariate model as predictors of micro- or macroalbuminuria at the 6-year follow-up visit: baseline serum uric acid levels, HbA(1c) and pre-albuminuria." | 3.76 | Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study. ( Jalal, DI; Johnson, RJ; Maahs, DM; McFann, K; Rewers, M; Rivard, CJ; Snell-Bergeon, JK, 2010) |
| "The relationship between elevated serum uric acid (SUA) and coronary heart disease (CHD) is discussed controversially." | 3.68 | Association of elevated serum uric acid with coronary heart disease in diabetes mellitus. ( Dannehl, K; Gries, FA; Hauner, H; Rathmann, W, 1993) |
| "To test the influence of oral fructose and glucose dose-response solutions in blood glucose (BG), glucagon, triglycerides, uricaemia, and malondialdehyde in postprandial states in type 1 diabetes mellitus (T1DM) patients." | 2.90 | Postprandial metabolic effects of fructose and glucose in type 1 diabetes patients: a pilot randomized crossover clinical trial. ( Dantas, JR; Lima, ÉDS; Rodacki, M; Rosado, EL; Souto, DL; Zajdenverg, L, 2019) |
| "A major challenge in preventing diabetic nephropathy is the inability to identify high-risk patients at an early stage, emphasizing the importance of discovering new therapeutic targets and implementation of clinical trials to reduce diabetic nephropathy risk." | 2.50 | Early diabetic nephropathy in type 1 diabetes: new insights. ( Bjornstad, P; Cherney, D; Maahs, DM, 2014) |
| "Uric acid has been associated with renal disease, even though hyperuricemia may be a marker of or by itself be responsible for microvascular disease in diabetes." | 2.47 | Serum uric acid as a new player in the development of diabetic nephropathy. ( Hovind, P; Johnson, RJ; Parving, HH; Rossing, P, 2011) |
| "NAFLD was determined by hepatic ultrasonography, then its clinical features were analyzed and its associated risk factors evaluated." | 1.48 | Prevalence and clinical characteristics of non-alcoholic fatty liver disease in newly diagnosed patients with ketosis-onset diabetes. ( Chen, MY; Jia, WP; Li, LX; Li, TT; Lu, JX; Tang, ZH; Wang, AP; Zhao, CC, 2018) |
| "In patients with Type 1 diabetes, higher PUA correlated with lower PGLO (P = 0." | 1.43 | Plasma uric acid effects on glomerular haemodynamic profile of patients with uncomplicated Type 1 diabetes mellitus. ( Cherney, DZ; Lai, V; Lytvyn, Y; Perkins, BA; Scholey, JW; Škrtić, M; Yang, GK; Yip, PM, 2016) |
| "Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults." | 1.40 | Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. ( Bjornstad, P; Chonchol, MB; Jalal, D; Johnson, RJ; Maahs, DM; McFann, K; Paul Wadwa, R; Rewers, M; Rivard, CJ; Sirota, JC; Snell-Bergeon, JK, 2014) |
| "147 patients (61 women and 86 men) with type 1 diabetes without increased urine albumin excretion were analysed." | 1.40 | Serum uric acid concentration is associated with early changes of glomerular filtration rate in patients with diabetes type 1 without increased albumin excretion. ( Korzeniewska-Dyl, I; Moczulski, D; Spaleniak, S, 2014) |
| "163 children, 116 with type 1 diabetes and 47 healthy controls, at the age 6-19 years were enrolled to the study." | 1.39 | The association between gene polymorphisms of glutathione S-transferase T1/M1 and type 1 diabetes in Slovak children and adolescents. ( Babusíková, E; Ciljaková, M; Durdík, P; Michnová, Z; Turcan, T; Vojtková, J, 2013) |
| "Uric acid was higher in subjects without diabetes than in those with diabetes (P = 0." | 1.37 | Uric acid levels are associated with microvascular endothelial dysfunction in patients with Type 1 diabetes. ( da Silva, PB; de Fátima Bevilácqua da Matta, M; Gomes, MB; Matheus, AS; Tibiriçá, E, 2011) |
| "We found a clear dose-response relation between serum uric acid and risk of early GFR loss in patients with type 1 diabetes." | 1.36 | High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up. ( Aschengrau, A; Doria, A; Eckfeldt, JH; Ficociello, LH; Galecki, AT; Krolewski, AS; Maselli, NJ; Niewczas, MA; Rosolowsky, ET; Stanton, RC; Warram, JH; Weinberg, JM, 2010) |
| "Uric acid was measured 3 years after onset of diabetes and before any patient developed microalbuminuria." | 1.35 | Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study. ( Hovind, P; Johnson, RJ; Parving, HH; Rossing, P; Tarnow, L, 2009) |
| "Adiponectin levels were higher in type 1 diabetes." | 1.35 | Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link. ( Boras, J; Erzen, DJ; Jazbec, A; Ljubic, S; Lovrencic, MV; Mileta, D; Vidjak, V, 2009) |
| "Sixteen patients with type 1 diabetes mellitus (DM), 25 patients with type 2 DM, and 24 systemically healthy patients, all with inflammatory periodontal disease, were recruited." | 1.35 | Salivary antioxidants in patients with type 1 or 2 diabetes and inflammatory periodontal disease: a case-control study. ( Buduneli, N; Cetinkalp, S; Gümüş, P; Hawkins, SI; Kinane, DF; Renaud, D; Scott, DA, 2009) |
| "Patients with type 1 diabetes and normoalbuminuria or microalbuminuria were recruited to the Second Joslin Kidney Study." | 1.35 | High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes. ( Binns, AL; Ficociello, LH; Krolewski, AS; Maselli, NJ; Niewczas, MA; Roshan, B; Rosolowsky, ET; Warram, JH, 2008) |
| "Uric acid was suppressed by 20% in the diabetic patients (P < 0." | 1.31 | Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes. ( Bryner, KD; Christie, I; Ganser, G; Hobbs, GR; Hoeldtke, RD; McNeill, DR; Riggs, JE; Van Dyke, K; Warehime, SS, 2002) |
| "Non-insulin-dependent DM (NIDDM) and insulin-dependent DM (IDDM) were diagnosed in 369 and 166 patients, respectively." | 1.31 | [Main causes of hyperuricemia in diabetes mellitus]. ( Balabolkin, MI; Madianov, IV; Markov, DS; Markova, TN, 2000) |
| "The incidence of preeclampsia was significantly associated with increasing urinary albumin excretion rate, primiparity, and ambulatory blood pressure." | 1.31 | Ambulatory blood pressure as predictor of preeclampsia in diabetic pregnancies with respect to urinary albumin excretion rate and glycemic regulation. ( Klebe, JG; Klebe, TM; Lauszus, FF; Lousen, T; Rasmussen, OW, 2001) |
| "We conclude that PIDDM patients have more severe renal dysfunction than NIDDM patients and, since glycosylated haemoglobin concentrations are comparable in these groups, we attribute this to a renal insult due to malnutrition predating the onset of the PIDDM." | 1.30 | Kidney function in phasic insulin dependent diabetes mellitus in Jamaica. ( Bennett, F; Morrison, EY; Ragoobirsingh, D, 1997) |
| "The uric acid tubular load was similar in both groups (2." | 1.29 | [Renal hypouricemia in juvenile diabetes mellitus]. ( Casero Ariza, J; Durá Travé, T; Moya Benavent, M, 1996) |
| "Epidemiologically, diabetes mellitus affects men by 64% and women by 36%." | 1.29 | [Diabetes mellitus at the National Hospital Center of Ouagadougou (Burkina Faso)]. ( Drabo, PY; Ilboudo, PD; Kabore, J; Lengani, A, 1996) |
| "The mean serum uric acid was lower in IDDM patients than in normal controls (4." | 1.28 | Urine uric acid excretion in patients with insulin-dependent diabetes mellitus. ( Boner, G; Carel, R; Erdberg, A; van Dyk, DJ, 1992) |
| "This increased variability in IDDM patients may be caused by variations in osmotic diuresis." | 1.27 | Intra-individual variation of some analytes in serum of patients with insulin-dependent diabetes mellitus. ( Hölzel, WG, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (12.39) | 18.7374 |
| 1990's | 21 (18.58) | 18.2507 |
| 2000's | 17 (15.04) | 29.6817 |
| 2010's | 39 (34.51) | 24.3611 |
| 2020's | 22 (19.47) | 2.80 |
| Authors | Studies |
|---|---|
| Cherney, DZI | 3 |
| Bjornstad, P | 8 |
| Perkins, BA | 6 |
| Rosenstock, J | 1 |
| Neubacher, D | 1 |
| Marquard, J | 1 |
| Soleymanlou, N | 1 |
| Sun, W | 1 |
| Shi, Y | 2 |
| Yang, J | 1 |
| Song, X | 1 |
| Zhang, Y | 2 |
| Zhang, W | 1 |
| Zhou, X | 3 |
| Di Bonito, P | 1 |
| Rosanio, FM | 1 |
| Marcovecchio, ML | 1 |
| Cherubini, V | 1 |
| Delvecchio, M | 1 |
| Di Candia, F | 1 |
| Iafusco, D | 1 |
| Zanfardino, A | 1 |
| Iovane, B | 1 |
| Maffeis, C | 1 |
| Maltoni, G | 1 |
| Ripoli, C | 3 |
| Piccinno, E | 1 |
| Piona, CA | 1 |
| Ricciardi, MR | 3 |
| Schiaffini, R | 1 |
| Franzese, A | 1 |
| Mozzillo, E | 1 |
| Zuncheddu, E | 2 |
| Angelo, MR | 2 |
| Pinna, AP | 2 |
| Ripoli, D | 2 |
| Jiang, J | 3 |
| Lan, L | 3 |
| Weng, J | 1 |
| Ren, W | 3 |
| Chen, W | 1 |
| Lu, D | 1 |
| Huang, Z | 1 |
| Xiao, L | 1 |
| Pilemann-Lyberg, S | 4 |
| Hansen, TW | 3 |
| Rossing, P | 7 |
| Słomiński, B | 2 |
| Ryba-Stanisławowska, M | 2 |
| Skrzypkowska, M | 2 |
| Gabig-Cimińska, M | 1 |
| Myśliwiec, M | 1 |
| Lee, WL | 1 |
| Wang, PH | 1 |
| Doria, A | 4 |
| Galecki, AT | 2 |
| Spino, C | 1 |
| Pop-Busui, R | 1 |
| Cherney, DZ | 4 |
| Lingvay, I | 1 |
| Parsa, A | 1 |
| Sigal, RJ | 1 |
| Afkarian, M | 1 |
| Aronson, R | 1 |
| Caramori, ML | 1 |
| Crandall, JP | 1 |
| de Boer, IH | 1 |
| Elliott, TG | 1 |
| Goldfine, AB | 1 |
| Haw, JS | 1 |
| Hirsch, IB | 1 |
| Karger, AB | 1 |
| Maahs, DM | 7 |
| McGill, JB | 1 |
| Molitch, ME | 1 |
| Polsky, S | 1 |
| Pragnell, M | 1 |
| Robiner, WN | 1 |
| Rosas, SE | 1 |
| Senior, P | 1 |
| Tuttle, KR | 1 |
| Umpierrez, GE | 1 |
| Wallia, A | 2 |
| Weinstock, RS | 1 |
| Wu, C | 1 |
| Mauer, M | 2 |
| Badve, SV | 1 |
| Pascoe, EM | 1 |
| Tiku, A | 1 |
| Boudville, N | 1 |
| Brown, FG | 1 |
| Cass, A | 1 |
| Clarke, P | 1 |
| Dalbeth, N | 1 |
| Day, RO | 1 |
| de Zoysa, JR | 1 |
| Douglas, B | 1 |
| Faull, R | 1 |
| Harris, DC | 1 |
| Hawley, CM | 1 |
| Jones, GRD | 1 |
| Kanellis, J | 1 |
| Palmer, SC | 1 |
| Perkovic, V | 1 |
| Rangan, GK | 1 |
| Reidlinger, D | 1 |
| Robison, L | 1 |
| Walker, RJ | 1 |
| Walters, G | 1 |
| Johnson, DW | 1 |
| Feig, DI | 1 |
| Zou, L | 1 |
| Wang, Y | 2 |
| Qiu, J | 1 |
| Yu, R | 1 |
| Pyne, L | 1 |
| Walsh, M | 1 |
| Pooni, RS | 1 |
| Corbett, R | 1 |
| Kang, DH | 1 |
| Sanchez-Lozada, LG | 1 |
| Johnson, RJ | 10 |
| Ponticelli, C | 1 |
| Podestà, MA | 1 |
| Conway, R | 1 |
| McCormick, N | 1 |
| Choi, HK | 1 |
| Fernandez-Prado, R | 1 |
| Ortiz, A | 1 |
| Perez-Gomez, MV | 1 |
| Floege, J | 1 |
| Jenkins, AJ | 1 |
| Braffett, BH | 1 |
| Basu, A | 1 |
| Bebu, I | 1 |
| Dagogo-Jack, S | 1 |
| Orchard, TJ | 1 |
| Lopes-Virella, MF | 1 |
| Garvey, WT | 1 |
| Lachin, JM | 1 |
| Lyons, TJ | 1 |
| Piani, F | 1 |
| Melena, I | 1 |
| Severn, C | 1 |
| Chung, LT | 1 |
| Vinovskis, C | 1 |
| Cherney, D | 2 |
| Pyle, L | 3 |
| Roncal-Jimenez, CA | 1 |
| Lanaspa, MA | 3 |
| Rewers, A | 1 |
| van Raalte, DH | 1 |
| Obeid, W | 1 |
| Parikh, C | 1 |
| Nelson, RG | 1 |
| Pavkov, ME | 1 |
| Nadeau, KJ | 1 |
| Gul, A | 1 |
| Harford, A | 1 |
| Zager, P | 1 |
| Lytvyn, Y | 5 |
| Har, R | 2 |
| Locke, A | 1 |
| Lai, V | 3 |
| Fong, D | 1 |
| Advani, A | 2 |
| Toyoki, D | 1 |
| Shibata, S | 1 |
| Kuribayashi-Okuma, E | 1 |
| Xu, N | 1 |
| Ishizawa, K | 1 |
| Hosoyamada, M | 1 |
| Uchida, S | 2 |
| Ma, Y | 1 |
| Cao, H | 1 |
| Li, Z | 1 |
| Fang, J | 1 |
| Wei, X | 1 |
| Cheng, P | 1 |
| Jiao, R | 1 |
| Liu, X | 1 |
| Li, Y | 1 |
| Xing, Y | 1 |
| Tang, J | 1 |
| Jin, L | 1 |
| Li, T | 1 |
| Bai, Y | 1 |
| Yang, R | 1 |
| Song, Y | 1 |
| Persson, F | 2 |
| Frystyk, J | 2 |
| Brandt, A | 1 |
| Li, TT | 1 |
| Wang, AP | 1 |
| Lu, JX | 1 |
| Chen, MY | 1 |
| Zhao, CC | 1 |
| Tang, ZH | 1 |
| Li, LX | 1 |
| Jia, WP | 1 |
| Theilade, S | 2 |
| Singh Ahluwalia, T | 1 |
| Zhou, XW | 1 |
| Fei, YY | 1 |
| Peng, L | 1 |
| Jiang, JL | 1 |
| Ye, SD | 1 |
| Lovshin, JA | 1 |
| Singh, SK | 1 |
| Boulet, G | 1 |
| Farooqi, MA | 1 |
| Tse, J | 1 |
| Cham, L | 1 |
| Lovblom, LE | 1 |
| Weisman, A | 1 |
| Keenan, HA | 1 |
| Brent, MH | 1 |
| Paul, N | 1 |
| Bril, V | 1 |
| Sochett, E | 2 |
| Tofte, N | 1 |
| Winther, SA | 1 |
| Ahluwalia, TS | 1 |
| Souto, DL | 1 |
| Lima, ÉDS | 1 |
| Dantas, JR | 1 |
| Zajdenverg, L | 1 |
| Rodacki, M | 1 |
| Rosado, EL | 1 |
| Simon, MC | 1 |
| Bilan, S | 1 |
| Nowotny, B | 1 |
| Dickhaus, T | 1 |
| Burkart, V | 1 |
| Schloot, NC | 1 |
| Krolewski, AS | 3 |
| Niewczas, MA | 3 |
| Skupien, J | 1 |
| Gohda, T | 1 |
| Smiles, A | 1 |
| Eckfeldt, JH | 2 |
| Warram, JH | 3 |
| Vojtková, J | 1 |
| Durdík, P | 1 |
| Ciljaková, M | 1 |
| Michnová, Z | 1 |
| Turcan, T | 1 |
| Babusíková, E | 1 |
| Ruilope, LM | 1 |
| Paul Wadwa, R | 1 |
| Sirota, JC | 1 |
| Snell-Bergeon, JK | 5 |
| McFann, K | 2 |
| Rewers, M | 3 |
| Rivard, CJ | 3 |
| Jalal, D | 2 |
| Chonchol, MB | 1 |
| Pafili, K | 1 |
| Katsiki, N | 2 |
| Mikhailidis, DP | 2 |
| Papanas, N | 2 |
| Malardé, L | 1 |
| Groussard, C | 1 |
| Lefeuvre-Orfila, L | 1 |
| Vincent, S | 1 |
| Efstathiou, T | 1 |
| Gratas-Delamarche, A | 1 |
| Škrtić, M | 2 |
| Yang, GK | 2 |
| Yip, PM | 2 |
| Spaleniak, S | 1 |
| Korzeniewska-Dyl, I | 1 |
| Moczulski, D | 1 |
| Ishimoto, T | 1 |
| Kosugi, T | 1 |
| Kume, S | 1 |
| Nakagawa, T | 1 |
| Scholey, JW | 2 |
| Roncal, C | 1 |
| Milagres, T | 1 |
| Bishop, FK | 1 |
| Wadwa, RP | 1 |
| Mahmud, FH | 1 |
| Daneman, D | 1 |
| Deda, L | 1 |
| Dunger, DB | 1 |
| Deanfield, J | 1 |
| Dalton, RN | 1 |
| Elia, Y | 1 |
| Bradley, TJ | 1 |
| Slorach, C | 1 |
| Hui, W | 1 |
| Moineddin, R | 1 |
| Reich, HN | 1 |
| Mertens, L | 1 |
| Selim, ME | 1 |
| Hendi, AA | 1 |
| Alfallaj, E | 1 |
| Ahola, AJ | 1 |
| Sandholm, N | 1 |
| Forsblom, C | 1 |
| Harjutsalo, V | 1 |
| Dahlström, E | 1 |
| Groop, PH | 1 |
| Hovind, P | 2 |
| Tarnow, L | 1 |
| Parving, HH | 2 |
| Cambuli, VM | 1 |
| Incani, M | 1 |
| Pilia, S | 1 |
| Congiu, T | 1 |
| Cavallo, MG | 1 |
| Cossu, E | 1 |
| Sentinelli, F | 1 |
| Mariotti, S | 1 |
| Loche, S | 1 |
| Baroni, MG | 1 |
| Ljubic, S | 1 |
| Boras, J | 1 |
| Jazbec, A | 1 |
| Lovrencic, MV | 1 |
| Vidjak, V | 1 |
| Erzen, DJ | 1 |
| Mileta, D | 1 |
| Gümüş, P | 1 |
| Buduneli, N | 1 |
| Cetinkalp, S | 1 |
| Hawkins, SI | 1 |
| Renaud, D | 1 |
| Kinane, DF | 1 |
| Scott, DA | 1 |
| Pitocco, D | 1 |
| Zaccardi, F | 1 |
| Di Stasio, E | 1 |
| Romitelli, F | 1 |
| Martini, F | 1 |
| Scaglione, GL | 1 |
| Speranza, D | 1 |
| Santini, S | 1 |
| Zuppi, C | 1 |
| Ghirlanda, G | 1 |
| Jalal, DI | 1 |
| Ficociello, LH | 2 |
| Rosolowsky, ET | 2 |
| Maselli, NJ | 2 |
| Weinberg, JM | 1 |
| Aschengrau, A | 1 |
| Stanton, RC | 1 |
| Matheus, AS | 1 |
| Tibiriçá, E | 1 |
| da Silva, PB | 1 |
| de Fátima Bevilácqua da Matta, M | 1 |
| Gomes, MB | 1 |
| Haeri, MR | 1 |
| Limaki, HK | 1 |
| White, CJ | 1 |
| White, KN | 1 |
| Fonseca, VA | 1 |
| Maltezos, E | 1 |
| Hoeldtke, RD | 2 |
| Bryner, KD | 1 |
| McNeill, DR | 1 |
| Hobbs, GR | 1 |
| Riggs, JE | 1 |
| Warehime, SS | 1 |
| Christie, I | 1 |
| Ganser, G | 1 |
| Van Dyke, K | 1 |
| Martín-Gallán, P | 1 |
| Carrascosa, A | 1 |
| Gussinye, M | 1 |
| Domínguez, C | 1 |
| Galusha, SA | 1 |
| Rock, KL | 1 |
| Reznick, AZ | 1 |
| Shehadeh, N | 1 |
| Shafir, Y | 1 |
| Nagler, RM | 1 |
| Waring, WS | 1 |
| McKnight, JA | 1 |
| Webb, DJ | 1 |
| Maxwell, SR | 2 |
| Binns, AL | 1 |
| Roshan, B | 1 |
| Sinagra, D | 2 |
| Amato, MP | 1 |
| Cangemi, C | 1 |
| La Sala, MS | 1 |
| Baggio, B | 1 |
| Gambaro, G | 1 |
| Marchi, A | 1 |
| Cicerello, E | 1 |
| Favaro, S | 1 |
| Borsatti, A | 1 |
| Botta, RM | 1 |
| Migliore, MG | 1 |
| Verga, S | 1 |
| García Puig, J | 2 |
| Mateos Antón, F | 2 |
| Grande Arajoú, C | 1 |
| Pallardo, LF | 2 |
| Arnalich, F | 2 |
| Montero García, A | 1 |
| Grande, C | 1 |
| Gaspar, G | 1 |
| Gil, A | 1 |
| Vázquez, JJ | 1 |
| Montero, A | 1 |
| Griesmacher, A | 1 |
| Kindhauser, M | 1 |
| Andert, SE | 1 |
| Schreiner, W | 1 |
| Toma, C | 1 |
| Knoebl, P | 1 |
| Pietschmann, P | 1 |
| Prager, R | 1 |
| Schnack, C | 1 |
| Schernthaner, G | 1 |
| Eggenberger, M | 1 |
| Asayama, K | 1 |
| Uchida, N | 1 |
| Nakane, T | 1 |
| Hayashibe, H | 1 |
| Dobashi, K | 1 |
| Amemiya, S | 1 |
| Kato, K | 1 |
| Nakazawa, S | 1 |
| Pearl, A | 1 |
| Hale, A | 1 |
| Whitehead, T | 1 |
| Rathmann, W | 1 |
| Hauner, H | 1 |
| Dannehl, K | 1 |
| Gries, FA | 1 |
| Zazgornik, J | 1 |
| Biesenbach, G | 1 |
| Janko, O | 1 |
| Grafinger, P | 1 |
| Kaiser, W | 1 |
| Stuby, U | 1 |
| Hubmann, R | 1 |
| Georgadze, ZO | 1 |
| Balabolkin, MI | 2 |
| Mamaeva, GG | 1 |
| Liudina, LI | 1 |
| Mishchenko, BP | 1 |
| Arbuzova, MI | 1 |
| Elbagir, MN | 1 |
| Eltom, MA | 1 |
| Mahadi, EO | 1 |
| Berne, C | 1 |
| Durá Travé, T | 1 |
| Moya Benavent, M | 1 |
| Casero Ariza, J | 1 |
| Drabo, PY | 1 |
| Kabore, J | 1 |
| Lengani, A | 1 |
| Ilboudo, PD | 1 |
| Ragoobirsingh, D | 1 |
| Bennett, F | 1 |
| Morrison, EY | 1 |
| Thomason, H | 1 |
| Sandler, D | 1 |
| Leguen, C | 1 |
| Baxter, MA | 1 |
| Thorpe, GH | 1 |
| Jones, AF | 1 |
| Barnett, AH | 1 |
| Vucić, M | 1 |
| Rocić, B | 1 |
| Bozikov, V | 1 |
| Ashcroft, SJ | 1 |
| González-Sicilia, L | 1 |
| García-Estañ, J | 1 |
| Martínez-Blázquez, A | 1 |
| Fernández-Pardo, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PERL: A Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D[NCT02017171] | Phase 3 | 530 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Diabetes Control and Complications Trial (DCCT)[NCT00360815] | 1,441 participants | Interventional | 1983-08-31 | Completed | |||
| Epidemiology of Diabetes Interventions and Complications (EDIC)[NCT00360893] | 1,441 participants (Actual) | Observational | 1994-04-30 | Active, not recruiting | |||
| A Deep Phenotyping Approach to Assess the Effect of Uric Acid Lowering in Patients With Uncomplicated Type 1 Diabetes Mellitus[NCT02344602] | Phase 4 | 73 participants (Actual) | Interventional | 2012-12-18 | Completed | ||
| Effect of Fructose and Glucose and TAS1R2 in Glucose, Triglycerides, Uremia, Oxidative Stress, Feelings Related to Food Intake of Individuals With Type 1 Diabetes[NCT01713023] | 16 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial[NCT02502071] | Phase 4 | 45 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| The Effect of Acute Fructose Load in Patients With Chronic Kidney Disease and Patients With Type 2 Diabetes Compared to Healthy Subjects[NCT03157960] | 20 participants (Actual) | Interventional | 2012-02-01 | Completed | |||
| Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 As Biomarkers of Acute Kidney Injury in Children With Diabetic Ketoacidosis[NCT06032325] | 48 participants (Anticipated) | Observational [Patient Registry] | 2024-01-01 | Not yet recruiting | |||
| Diabetic Kidney Alarm (DKA) Study - Tubulopathy in Diabetic Ketoacidosis[NCT03128229] | 41 participants (Actual) | Observational | 2017-06-01 | Completed | |||
| Effects of Low Intensity Aerobic Exercise Training on the Microvascular Endothelial Function of Patients With Type 1 Diabetes: a Non-pharmacological Interventional Study[NCT02441504] | 22 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Geometric mean of urinary albumin excretion rate (AER) during the last three months of the treatment period (Visits 15 and 16), adjusted for the mean urinary AER at baseline. Results are expressed as least square means of the geometric means in each subject in each group. (NCT02017171)
Timeframe: Last three months of treatment period (Weeks 142 and 156)
| Intervention | ug/min (Least Squares Mean) |
|---|---|
| Allopurinol | 47.9 |
| Placebo | 37.4 |
Geometric mean of two urinary albumin excretion (AER) measurements at the end of the 2-month wash-out period following the 3-year treatment period, adjusted for the mean urinary AER at baseline. Results are expressed as least square means of the geometric means in each subject in each group. (NCT02017171)
Timeframe: End of the 2-month wash-out period following the 3-year treatment period (week 164)
| Intervention | ug/min (Least Squares Mean) |
|---|---|
| Allopurinol | 42.9 |
| Placebo | 31.7 |
Glomerular filtration rate (GFR) at 4 months after randomization, estimated from serum creatinine and cystatin C and adjusted for the eGFR at baseline. (NCT02017171)
Timeframe: 4 months after randomization (week 16)
| Intervention | ml/min/1.73 m2 (Least Squares Mean) |
|---|---|
| Allopurinol | 70.3 |
| Placebo | 70.0 |
Glomerular filtration rate time trajectory from baseline to end of the 2-month wash-out period (week 164) estimated from quarterly serum creatinine measurements (eGFR). eGFR slopes were estimated by a linear mixed-effects model for longitudinal eGFR measures using a multiple imputation technique for missing values. Positive values denote increasing eGFR over time, negative values denote declining eGFR over time. (NCT02017171)
Timeframe: Weeks 0, 4, 16, 32, 48, 64, 80, 96, 112, 128, 156, and 164 (from baseline to the end of washout period)
| Intervention | ml/min/1.73 m2/year (Least Squares Mean) |
|---|---|
| Allopurinol | -2.4 |
| Placebo | -2.1 |
Risk of cardiovascular events defined as the composite of CVD death (ICD-10 code I10 to I74.9), myocardial infarction, stroke (ischemic or hemorrhagic), coronary artery bypass grafting, or percutaneous coronary intervention in the allopurinol arm as compared to placebo.Results are expressed as the number of participants who experienced an event in each treatment group. The risk of an event in the allopurinol group as compared to the risk in the placebo group is expressed as hazard ratio (estimated by means of proportional hazard regression). (NCT02017171)
Timeframe: Up to the end of the 2-month wash-out period following the 3-year treatment period (week 0 to 164)
| Intervention | Participants (Count of Participants) |
|---|---|
| Allopurinol | 15 |
| Placebo | 9 |
Glomerular filtration rate (GFR) at the end of the 2-month wash-out period following the 3-year treatment period, measured by the plasma disappearance of non-radioactive iohexol (iGFR) and adjusted for the iGFR at baseline. (NCT02017171)
Timeframe: End of the 2-month wash-out period following the 3-year treatment period (week 164)
| Intervention | ml/min/1.73 m^2 (Least Squares Mean) |
|---|---|
| Allopurinol | 61.2 |
| Placebo | 61.2 |
Glomerular filtration rate (GFR) at the end of the 3-year treatment period, measured by the plasma disappearance of non-radioactive iohexol (iGFR) and adjusted for the iGFR at baseline. (NCT02017171)
Timeframe: End of the 3-yr treatment period (week 156)
| Intervention | ml/min/1.73 m2 (Least Squares Mean) |
|---|---|
| Allopurinol | 61.3 |
| Placebo | 61.0 |
Glomerular filtration rate time trajectory estimated from iohexol disappearance GFR (iGFR) measurements at weeks 0, 80, 156, and 164. iGFR slopes were estimated by a linear mixed-effects model for longitudinal iGFR measures using a multiple imputation technique for missing values. Positive values denote increasing GFR over time, negative values denote declining iGFR over time. (NCT02017171)
Timeframe: Weeks 0, 80, 156, and 164 (from baseline to the end of washout period)
| Intervention | ml/min/1.73 m2/year (Least Squares Mean) |
|---|---|
| Allopurinol | -3.0 |
| Placebo | -2.5 |
Risk of serum creatinine doubling or end stage renal disease (ESRD) in the allopurinol arm as compared to placebo. Results are expressed as the number of participants who experienced an event in each treatment group. The risk of an event in the allopurinol group as compared to the risk in the placebo group is expressed as hazard ratio (estimated by means of proportional hazard regression). (NCT02017171)
Timeframe: Up to the end of the 2-month wash-out period following the 3-year treatment period (Week 0 to Week 164)
| Intervention | Participants (Count of Participants) |
|---|---|
| Allopurinol | 13 |
| Placebo | 11 |
Urine uric acid crystals were identified by polarized microscopy (Polarized light imaging Zeiss Axiovert 135; 0.3NA objective), and pictures were captured from each urine sample. UA crystals were defined dichotomously as being present or absent. (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)
| Intervention | participants (Number) | |
|---|---|---|
| Day 1 (pre-therapy) | Day 2 (post-therapy) | |
| Sodium Bicarbonate | 14 | 3 |
Urine uric acid were evaluated using a QuantiChrom UA kit assay (DIUA-250) with quantitative colorimetric UA determination at 590 nm (BioAssay System, California, USA). (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)
| Intervention | mg/dl (Geometric Mean) | |
|---|---|---|
| Day 1 (pre-therapy) | Day 2 (post-therapy) | |
| Sodium Bicarbonate | 23.81 | 22.30 |
7 reviews available for uric acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Uric Acid and Diabetic Nephropathy Risk.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Progression; Glomerular Filt | 2018 |
Early diabetic nephropathy in type 1 diabetes: new insights.
Topics: Angiotensin II Type 2 Receptor Blockers; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease | 2014 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Fructose and uric acid in diabetic nephropathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2015 |
Serum uric acid as a new player in the development of diabetic nephropathy.
Topics: Allopurinol; Animals; Antimetabolites; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Mo | 2011 |
Uric acid and diabetes: Is there a link?
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies | 2013 |
[Hypertension, Type II diabetes mellitus and macroangiopathy: risk factors and their association].
Topics: Albuminuria; Alcohol Drinking; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Exercise; Female; H | 1994 |
[Proximal renal tubular dysfunction in insulin-dependent diabetes mellitus].
Topics: Calcium; Diabetes Mellitus, Type 1; Fanconi Syndrome; Humans; Kidney Tubules; Magnesium; Uric Acid | 2001 |
7 trials available for uric acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
Topics: Adult; Aged; Allopurinol; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Double-Blind Method; En | 2020 |
Effects of Allopurinol on the Progression of Chronic Kidney Disease.
Topics: Aged; Allopurinol; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Progression; Double-Bl | 2020 |
Serum urate and cardiovascular events in the DCCT/EDIC study.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Female; Heart Disease Risk Factors; Human | 2021 |
Serum urate and cardiovascular events in the DCCT/EDIC study.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Female; Heart Disease Risk Factors; Human | 2021 |
Serum urate and cardiovascular events in the DCCT/EDIC study.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Female; Heart Disease Risk Factors; Human | 2021 |
Serum urate and cardiovascular events in the DCCT/EDIC study.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Female; Heart Disease Risk Factors; Human | 2021 |
The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial.
Topics: Albuminuria; Allopurinol; Creatinine; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetic Nephro | 2018 |
Postprandial metabolic effects of fructose and glucose in type 1 diabetes patients: a pilot randomized crossover clinical trial.
Topics: Adolescent; Adult; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 1; Dose-Response Relat | 2019 |
Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study.
Topics: Adult; Calcinosis; Coronary Artery Disease; Coronary Vessels; Diabetes Mellitus, Type 1; Diabetic An | 2014 |
Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers.
Topics: Acetylcholine; Adult; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Blood Pressure; Body Mass In | 2006 |
99 other studies available for uric acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Kidney Effects of Empagliflozin in People with Type 1 Diabetes.
Topics: Albuminuria; Benzhydryl Compounds; Clinical Trials, Phase III as Topic; Controlled Clinical Trials a | 2021 |
Transthyretin and retinol-binding protein as discriminators of diabetic retinopathy in type 1 diabetes mellitus.
Topics: Apolipoproteins B; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Homocysteine; Humans; Prealbumin | 2022 |
Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes.
Topics: Adolescent; Blood Pressure; Cardiovascular Diseases; Child; Cholesterol, HDL; Diabetes Mellitus, Typ | 2022 |
Emotional eating and disordered eating behaviors in children and adolescents with type 1 diabetes.
Topics: Adolescent; Child; Diabetes Mellitus, Type 1; Feeding and Eating Disorders; Glycated Hemoglobin; Hum | 2022 |
Emotional eating and disordered eating behaviors in children and adolescents with type 1 diabetes.
Topics: Adolescent; Child; Diabetes Mellitus, Type 1; Feeding and Eating Disorders; Glycated Hemoglobin; Hum | 2022 |
Emotional eating and disordered eating behaviors in children and adolescents with type 1 diabetes.
Topics: Adolescent; Child; Diabetes Mellitus, Type 1; Feeding and Eating Disorders; Glycated Hemoglobin; Hum | 2022 |
Emotional eating and disordered eating behaviors in children and adolescents with type 1 diabetes.
Topics: Adolescent; Child; Diabetes Mellitus, Type 1; Feeding and Eating Disorders; Glycated Hemoglobin; Hum | 2022 |
The correlation between serum uric acid and diabetic kidney disease in adult-onset type 1 diabetes patients in China.
Topics: Adult; China; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glomerul | 2023 |
The correlation between serum uric acid and diabetic kidney disease in type 1 diabetes patients in Anhui, China.
Topics: China; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Humans; Hyperuricemia; Uric Acid | 2023 |
Comment on Pilemann-Lyberg et al. Uric Acid Is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Events, and Mortality in Patients With Type 1 Diabetes. Diabetes Care 2019;42:1088-1094.
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Risk Factors; | 2019 |
Response to Comment on Pilemann-Lyberg et al. Uric Acid Is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Events, and Mortality in Patients With Type 1 Diabetes. Diabetes Care 2019;42:1088-1094.
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Risk Factors; | 2019 |
A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents.
Topics: Adolescent; Biomarkers; Blood Pressure; Cytokines; Diabetes Mellitus, Type 1; Female; Genotype; Gluc | 2020 |
Uric acid in diabetic nephropathy.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; | 2020 |
Urate-Lowering Therapy and Chronic Kidney Disease Progression.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Disease Progression; Gout Suppressants; Humans; Renal Insuff | 2020 |
Comment on "Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?"
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Uric Acid | 2020 |
Allopurinol: Good for Gout But Not for Preventing Loss of Kidney Function.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout; Gout Suppressants; Humans; Kidney; Uric Acid | 2021 |
Research in brief: Serum urate reduction and its effect on the progression of chronic kidney disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Disease Progression; Gout; Humans; Kidney; Renal Insufficien | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uri | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uri | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uri | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uri | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uri | 2020 |
Hyperuricemia and progression of chronic kidney disease: to treat or not to treat?
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Hyperuricemia; Kidney; Renal Insu | 2021 |
Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study.
Topics: Acute Kidney Injury; Adolescent; Biomarkers; Child; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis | 2021 |
Mendelian randomization to establish the causality of uric acid with diabetic nephropathy in type 1 diabetics.
Topics: Diabetes Mellitus, Type 1; Diabetic Nephropathies; Humans; Hyperuricemia; Random Allocation; Uric Ac | 2017 |
Renal and Vascular Effects of Uric Acid Lowering in Normouricemic Patients With Uncomplicated Type 1 Diabetes.
Topics: Adult; Angiotensin II; Blood Pressure; Case-Control Studies; Diabetes Mellitus, Type 1; Febuxostat; | 2017 |
Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2.
Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood Gl | 2017 |
A Novel Multi-Epitope Vaccine Based on Urate Transporter 1 Alleviates Streptozotocin-Induced Diabetes by Producing Anti-URAT1 Antibody and an Immunomodulatory Effect in C57BL/6J Mice.
Topics: Animals; Antioxidants; Autoantibodies; Autoantigens; Cytokines; Diabetes Mellitus, Experimental; Dia | 2017 |
Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages.
Topics: Adult; Aged; Biomarkers; Deoxyglucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabeti | 2019 |
Sex-related association of serum uric acid with inflammation, kidney function and blood pressure in type 1 diabetic patients.
Topics: Adolescent; Blood Pressure; Child; Cohort Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies | 2018 |
Prevalence and clinical characteristics of non-alcoholic fatty liver disease in newly diagnosed patients with ketosis-onset diabetes.
Topics: Adult; Aged; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ | 2018 |
Uric acid is not associated with diabetic nephropathy and other complications in type 1 diabetes.
Topics: Biomarkers; Blood Pressure Determination; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes | 2019 |
[Related factors of diabetic nephropathy in patients with type 1 diabetes mellitus].
Topics: Blood Glucose; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2018 |
Association between uric acid, renal haemodynamics and arterial stiffness over the natural history of type 1 diabetes.
Topics: Adolescent; Adult; Age Factors; Aged; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; | 2019 |
Uric Acid Is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Events, and Mortality in Patients With Type 1 Diabetes.
Topics: Adult; Aged; Albuminuria; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mel | 2019 |
Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes.
Topics: Adult; alpha-Linolenic Acid; Case-Control Studies; Chemokines; Cytokines; Diabetes Mellitus, Type 1; | 2013 |
Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria.
Topics: Adult; Albuminuria; Creatinine; Cystatin C; Diabetes Mellitus, Type 1; Disease Progression; Female; | 2014 |
The association between gene polymorphisms of glutathione S-transferase T1/M1 and type 1 diabetes in Slovak children and adolescents.
Topics: Adolescent; Adult; Child; Diabetes Mellitus, Type 1; Female; Genetic Predisposition to Disease; Glut | 2013 |
Blood pressure and uric acid in diabetes mellitus.
Topics: Blood Pressure; Diabetes Mellitus, Type 1; Female; Humans; Hypertension; Male; Uric Acid | 2014 |
Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes.
Topics: Adult; Blood Pressure; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabe | 2014 |
Serum uric acid as a predictor of vascular complications in diabetes: an additional case for neuropathy.
Topics: Coronary Artery Disease; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Humans; Male; Uri | 2014 |
Fermented soy permeate reduces cytokine level and oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Diabet | 2015 |
Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus.
Topics: Adult; Benzhydryl Compounds; Case-Control Studies; Diabetes Mellitus, Type 1; Female; Glucosides; Gl | 2015 |
Serum uric acid concentration is associated with early changes of glomerular filtration rate in patients with diabetes type 1 without increased albumin excretion.
Topics: Adult; Albuminuria; Biomarkers; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Early Diagnosis; | 2014 |
Plasma uric acid effects on glomerular haemodynamic profile of patients with uncomplicated Type 1 diabetes mellitus.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Hemodyna | 2016 |
Hyperfiltration and uricosuria in adolescents with type 1 diabetes.
Topics: Adolescent; Age Factors; Biomarkers; Case-Control Studies; Child; Creatinine; Cross-Sectional Studie | 2016 |
Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes.
Topics: Adolescent; Blood Pressure; Cardio-Renal Syndrome; Cardiovascular System; Case-Control Studies; Chil | 2016 |
The possible counteractive effect of gold nanoparticles against streptozotocin-induced type 1 diabetes in young male albino rats.
Topics: Age Factors; Animals; Antioxidants; Biomarkers; Blood Glucose; Blood Urea Nitrogen; Creatinine; Diab | 2016 |
The serum uric acid concentration is not causally linked to diabetic nephropathy in type 1 diabetes.
Topics: Adult; Albuminuria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetic Nephrop | 2017 |
Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study.
Topics: Adolescent; Adult; Albuminuria; Blood Pressure; Cohort Studies; Diabetes Mellitus, Type 1; Diabetic | 2009 |
Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes.
Topics: Adolescent; Aging; Blood Glucose; Body Mass Index; Child; Cohort Studies; Diabetes Mellitus, Type 1; | 2009 |
Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link.
Topics: Adiponectin; Adult; C-Peptide; C-Reactive Protein; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ | 2009 |
Salivary antioxidants in patients with type 1 or 2 diabetes and inflammatory periodontal disease: a case-control study.
Topics: Adolescent; Adult; Aged; Antioxidants; Ascorbic Acid; Case-Control Studies; Dental Plaque Index; Dia | 2009 |
Role of asymmetric-dimethyl-L-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitus.
Topics: Adult; Arginine; Blood Glucose; Blood Specimen Collection; Cholesterol; Cholesterol, HDL; Cholestero | 2009 |
Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study.
Topics: Adult; Albuminuria; Biomarkers; Cohort Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; F | 2010 |
High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up.
Topics: Adolescent; Adult; Albuminuria; Creatinine; Cystatin C; Diabetes Mellitus, Type 1; Disease Progressi | 2010 |
Uric acid levels are associated with microvascular endothelial dysfunction in patients with Type 1 diabetes.
Topics: Adult; Analysis of Variance; Biomarkers; Blood Glucose; Coronary Artery Disease; Cross-Sectional Stu | 2011 |
Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hypoglycemic Age | 2012 |
Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes.
Topics: Adolescent; Adult; Autonomic Nervous System; Child; Diabetes Mellitus, Type 1; Dinoprost; F2-Isopros | 2002 |
Nitrosative stress in early Type 1 diabetes. David H. P. Streeten Memorial Lecture.
Topics: Adolescent; Adult; Autonomic Nervous System; Child; Diabetes Mellitus, Type 1; Female; Hemodynamics; | 2003 |
Estimation of lipoperoxidative damage and antioxidant status in diabetic children: relationship with individual antioxidants.
Topics: Adolescent; alpha-Tocopherol; Antioxidants; Biomarkers; Child; Cholesterol; Diabetes Mellitus, Type | 2005 |
Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model.
Topics: Adjuvants, Immunologic; Adoptive Transfer; Animals; Antigen-Presenting Cells; Antigens; Autoimmunity | 2006 |
Free radicals related effects and antioxidants in saliva and serum of adolescents with Type 1 diabetes mellitus.
Topics: Adolescent; Adult; Amylases; Antioxidants; Biomarkers; Blood Glucose; Case-Control Studies; Chi-Squa | 2006 |
High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes.
Topics: Adult; Age Factors; Albuminuria; Antihypertensive Agents; Blood Pressure; Cross-Sectional Studies; C | 2008 |
[Various biohumoral parameters (blood triglycerides, blood cholesterol, blood uric acid, blood electrolytes) after automatic control by an artificial pancreas in subjects with type I diabetes mellitus].
Topics: Adolescent; Cholesterol; Diabetes Mellitus, Type 1; Electrolytes; Female; Humans; Insulin Infusion S | 1984 |
The role of glycosaminoglycans and uric acid in idiopathic calcium nephrolithiasis.
Topics: Calcium Oxalate; Diabetes Mellitus, Type 1; Glomerulonephritis; Glycosaminoglycans; Humans; Kidney C | 1984 |
[Effects of acute ingestion of ethanol on several metabolic parameters (blood sugar, triglycerides, non-esterified fatty acids, lactic acid and uric acid) in subjects with type I diabetes mellitus].
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Ethanol; Fatty Acids, Nonesterified; Fe | 1982 |
[Tubular function and renal acidifying in juvenile diabetes mellitus of short evolution].
Topics: Adolescent; Calcium; Child; Chlorides; Diabetes Mellitus, Type 1; Female; Humans; Hydrogen-Ion Conce | 1981 |
Renal tubular function and urinary acidification capacity in early juvenile diabetes.
Topics: Adolescent; Child; Diabetes Mellitus, Type 1; Electrolytes; Female; Glomerular Filtration Rate; Huma | 1981 |
Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus.
Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus | 1995 |
Antioxidants in the serum of children with insulin-dependent diabetes mellitus.
Topics: Adolescent; Antioxidants; Ascorbic Acid; Child; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Fe | 1993 |
Serum urate as a free radical scavenger in diabetics.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Free Radical Scavengers; Humans; Luminescent M | 1993 |
Association of elevated serum uric acid with coronary heart disease in diabetes mellitus.
Topics: Adolescent; Adult; Aged; Biomarkers; Body Weight; Coronary Disease; Cross-Sectional Studies; Diabete | 1993 |
[Serum uric acid level in type 1 and type 2 diabetic patients].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus | 1996 |
[Kidney lesions in non-insulin dependent diabetes mellitus].
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; G | 1995 |
Pattern of long-term complications in Sudanese insulin-treated diabetic patients.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cerebrovascular Disord | 1995 |
[Renal hypouricemia in juvenile diabetes mellitus].
Topics: Adolescent; Blood Glucose; Child; Child, Preschool; Creatinine; Diabetes Mellitus, Type 1; Diabetic | 1996 |
[Diabetes mellitus at the National Hospital Center of Ouagadougou (Burkina Faso)].
Topics: Adult; Burkina Faso; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetes Me | 1996 |
Kidney function in phasic insulin dependent diabetes mellitus in Jamaica.
Topics: Albuminuria; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathie | 1997 |
Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus.
Topics: Adult; Antioxidants; Ascorbic Acid; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellit | 1997 |
Plasma uric acid and total antioxidant status in patients with diabetes mellitus.
Topics: Adult; Antioxidants; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Human | 1997 |
Renal metabolism of uric acid in type I insulin-dependent diabetic patients: relation to metabolic compensation.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Humans; Kidney; Male; Uric Acid | 1997 |
Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM.
Topics: Adolescent; Antioxidants; Ascorbic Acid; Autoantibodies; Autoimmunity; Child; Diabetes Mellitus, Typ | 1998 |
Purine catabolism: links to mitochondrial respiration and antioxidant defenses?
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Guanine; Guanosin | 1999 |
[Main causes of hyperuricemia in diabetes mellitus].
Topics: Adult; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glycosuria; | 2000 |
Ascorbyl free radical release in diabetic patients.
Topics: Antioxidants; Ascorbic Acid; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Typ | 2000 |
Ambulatory blood pressure as predictor of preeclampsia in diabetic pregnancies with respect to urinary albumin excretion rate and glycemic regulation.
Topics: Adolescent; Adult; Albuminuria; Birth Weight; Blood Glucose; Blood Pressure; Blood Pressure Monitori | 2001 |
Plasma antioxidants in pediatric patients with glycogen storage disease, diabetes mellitus, and hypercholesterolemia.
Topics: Adolescent; Adult; Antioxidants; Ascorbic Acid; Child; Child, Preschool; Cholesterol; Chromatography | 2002 |
[Use of xylitol as sugar substitute in diabetic children].
Topics: Adolescent; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diet, Diabetic; Female; Humans; Male | 1977 |
[Renal regulation of uric acid metabolism in diabetes].
Topics: Adolescent; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Humans; Kidney; Male; Uric A | 1976 |
[Glycoproteins in diabetes mellitus].
Topics: Adolescent; Adult; Aged; alpha 1-Antitrypsin; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Typ | 1975 |
Urine uric acid excretion in patients with insulin-dependent diabetes mellitus.
Topics: Adult; Diabetes Mellitus, Type 1; Female; Glycosuria; Humans; Male; Prevalence; Uric Acid | 1992 |
Plasma urate in diabetes: relationship to glycaemia, glucose disposal, microvascular complications and the variations following oral glucose.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; | 1991 |
Insulin-dependent diabetes and renal hypouricemia.
Topics: Adolescent; Adult; Creatinine; Diabetes Mellitus, Type 1; Female; Humans; Kidney Tubules; Male; Prob | 1991 |
Unilateral renal agenesis associated with various metabolic disorders in three siblings.
Topics: Adult; Aortography; Cholelithiasis; Diabetes Mellitus, Type 1; Female; Humans; Hyperbilirubinemia; K | 1990 |
[Evidence of abnormal kidney processing of uric acid in patients with insulin-dependent diabetes mellitus].
Topics: Adolescent; Adult; Age Factors; Diabetes Mellitus, Type 1; Female; Humans; Kidney Tubules, Proximal; | 1990 |
Early alterations of renal function in insulin-dependent diabetic pregnancies and their importance in predicting pre-eclamptic toxaemia.
Topics: Adult; Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus, Type 1; Female; Glycated Hemogl | 1989 |
Intra-individual variation of some analytes in serum of patients with insulin-dependent diabetes mellitus.
Topics: Adult; Blood Glucose; Blood Proteins; Creatinine; Diabetes Mellitus, Type 1; Electrolytes; Enzymes; | 1987 |
An evaluation of factors associated with proliferative diabetic retinopathy.
Topics: Adult; Angina Pectoris; Blood Coagulation; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neurop | 1985 |
[Glucose, fructose, sorbitol and xylitol metabolism in man].
Topics: Acidosis; Adenine Nucleotides; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Fructose; Glucose; | 1973 |
[Renal excretion of uric acid in diabetic children].
Topics: Adolescent; Child; Diabetes Mellitus, Type 1; Female; Humans; Kidney; Male; Uric Acid | 1971 |
[Behavior and significance of blood uric acid in diabetes mellitus].
Topics: Age Factors; Arteriosclerosis; Diabetes Mellitus; Diabetes Mellitus, Type 1; Female; Humans; Male; M | 1967 |