Page last updated: 2024-10-20

uric acid and Atheroma

uric acid has been researched along with Atheroma in 25 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
"Serum uric acid increases with metabolic disorders; however, whether the effects of uric acid on atherosclerosis are different in females and males has not been sufficiently evaluated."8.12Increased Impact of Serum Uric Acid on Arterial Stiffness and Atherosclerosis in Females. ( Dohi, Y; Iwase, M; Nagami, T; Ohte, N; Seo, Y; Sugiura, T; Suzuki, K; Takagi, Y; Takase, H; Tomiishi, T; Yokochi, T; Yoshikane, N, 2022)
"The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo."7.96Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. ( Hosoyamada, M; Kimura, Y; Kono, H; Onda, A; Tsukui, D; Yanagida, T, 2020)
"Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS)."7.88Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study. ( Lin, L; Wang, N; Yu, B; Zhang, D; Zhang, R, 2018)
"To explore the associations between urine uric acid excretion (UUAE) and diabetic retinopathy (DR)/lower limb atherosclerotic lesions in hospitalized Chinese patients with type 2 diabetes."7.81Decreased urine uric acid excretion is associated with diabetic retinopathy but not with lower limb atherosclerosis in hospitalized patients with type 2 diabetes. ( Bao, YQ; Chen, MY; Jia, WP; Li, LX; Li, TT; Lu, JX; Shuai, HP; Wang, JW; Xia, HF; Zhang, R, 2015)
"Although many studies have examined the relationship between uric acid (UA) and coronary artery disease (CAD), whether UA is an independent risk factor contributing to progression of CAD is still controversial."7.80A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China. ( Chen, L; Geng, S; Li, H; Liu, T; Qi, G; Sun, Y; Wu, C; Xu, K; Yu, X; Zhi, Y, 2014)
" Based on preclinical and clinical evidences, this review discusses: (i) stone forming risk factors, crystal nucleation, aggregation, injury-induced crystal retention, and stone formation, (ii) CVD risk factors such as dyslipidemia, perturbation of gut microbiome, obesity, free radical-induced lipoprotein oxidation, and retention in the arterial wall, subsequent foam cell formation, and atherosclerosis, (iii) mechanism by which stone forming risk factors such as oxalate, calcium, uric acid, and infection contribute toward CVDs, and (iv) how CVD risk factors, such as cholesterol, phospholipids, and uric acid, contribute to kidney stone formation are described."4.98Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases. ( Devarajan, A, 2018)
"Serum uric acid increases with metabolic disorders; however, whether the effects of uric acid on atherosclerosis are different in females and males has not been sufficiently evaluated."4.12Increased Impact of Serum Uric Acid on Arterial Stiffness and Atherosclerosis in Females. ( Dohi, Y; Iwase, M; Nagami, T; Ohte, N; Seo, Y; Sugiura, T; Suzuki, K; Takagi, Y; Takase, H; Tomiishi, T; Yokochi, T; Yoshikane, N, 2022)
"The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo."3.96Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. ( Hosoyamada, M; Kimura, Y; Kono, H; Onda, A; Tsukui, D; Yanagida, T, 2020)
"Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS)."3.88Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study. ( Lin, L; Wang, N; Yu, B; Zhang, D; Zhang, R, 2018)
"To explore the associations between urine uric acid excretion (UUAE) and diabetic retinopathy (DR)/lower limb atherosclerotic lesions in hospitalized Chinese patients with type 2 diabetes."3.81Decreased urine uric acid excretion is associated with diabetic retinopathy but not with lower limb atherosclerosis in hospitalized patients with type 2 diabetes. ( Bao, YQ; Chen, MY; Jia, WP; Li, LX; Li, TT; Lu, JX; Shuai, HP; Wang, JW; Xia, HF; Zhang, R, 2015)
"Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS)."3.81Relation of Lipid Content of Coronary Plaque to Level of Serum Uric Acid. ( Fujimoto, Y; Kobayashi, Y; Nakayama, T; Saito, Y; Sugimoto, K, 2015)
"Although many studies have examined the relationship between uric acid (UA) and coronary artery disease (CAD), whether UA is an independent risk factor contributing to progression of CAD is still controversial."3.80A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China. ( Chen, L; Geng, S; Li, H; Liu, T; Qi, G; Sun, Y; Wu, C; Xu, K; Yu, X; Zhi, Y, 2014)
"Acute rupture or erosion of unstable atherosclerotic plaques is a major cause of adverse consequences of atherosclerotic cardiovascular disease, often leading to myocardial infarction or stroke."1.91High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy. ( Chen, B; Cheng, J; He, F; Koyama, H; Liu, W; Lv, J; Wang, Q; Xu, C; Yamamoto, T; Yu, W; Zhao, H, 2023)
"Hyperuricemia was associated with greater NLRP3 and gasdermin-D expression on human atheroma plaques in patients with peripheral artery disease."1.72Birefringent crystals deposition and inflammasome expression in human atheroma plaques by levels of uricemia. ( Andrés, M; Argente-Del-Castillo, E; Mendieta, L; Miñano, A; Pascual, E; Trigueros, M, 2022)
"Coronary atherosclerotic plaques (calcified, mixed, and non-calcified plaques) were assessed using CCTA."1.51Serum uric acid level and subclinical coronary atherosclerosis in asymptomatic individuals: An observational cohort study. ( Choe, J; Choi, SW; Hong, S; Kang, JW; Kim, HK; Kim, YG; Kim, YH; Lee, CK; Lee, SW; Lee, Y; Lim, DH; Lim, TH; Park, GM; Yang, DH; Yoo, B, 2019)
"Atherosclerosis is considered as an inflammatory disease, and carotid artery intima-media thickness (IMT) and carotid plaque are generally used as intermediated phenotype of atherosclerosis."1.42Association of interleukin-10 promoter region polymorphisms with risk factors of Atherosclerosis. ( Cho, HC; Chung, IS; Chung, JH; Jun, SE; Park, KO; Shin, DH; Yu, GI, 2015)
"The total burden of subclinical coronary atherosclerosis is significant in young adults."1.42Evaluation of lipoprotein-associated phosholipase A2 and plaque burden/composition in young adults. ( Akin, F; Akturk, F; Ayca, B; Birand, A; Celik, O; Erturk, M; Kaya, MG; Ozturk, D; Pusuroglu, H; Satilmis, S; Yalcin, AA, 2015)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (72.00)24.3611
2020's7 (28.00)2.80

Authors

AuthorsStudies
Tan, Y1
Qing, J1
Wu, G1
Li, X1
Guo, F1
Wang, Y2
Wang, L1
Li, M1
Sugiura, T1
Dohi, Y1
Takagi, Y1
Yokochi, T1
Yoshikane, N1
Suzuki, K1
Tomiishi, T1
Nagami, T1
Iwase, M1
Takase, H1
Ohte, N1
Seo, Y1
Yu, W4
Liu, W4
Wang, Q4
Xu, C4
Zhao, H4
Lv, J4
He, F4
Chen, B4
Yamamoto, T4
Koyama, H4
Cheng, J4
Andrés, M1
Mendieta, L1
Argente-Del-Castillo, E1
Trigueros, M1
Miñano, A1
Pascual, E1
Chu, X1
Lu, Y1
Mei, M1
Peng, P1
Zhao, Y1
Fu, G1
Qiu, F1
Jin, C1
Kimura, Y1
Yanagida, T1
Onda, A1
Tsukui, D1
Hosoyamada, M1
Kono, H1
Zhang, H1
Devarajan, A1
Zhang, D1
Zhang, R2
Wang, N1
Lin, L1
Yu, B1
Lv, S1
Ohene, BE1
Zhou, Y2
Lim, DH1
Lee, Y1
Park, GM1
Choi, SW1
Kim, YG2
Lee, SW1
Kim, YH1
Yang, DH1
Kang, JW1
Lim, TH1
Kim, HK1
Choe, J1
Hong, S1
Lee, CK1
Yoo, B1
Tan, C1
Liu, Y1
Li, W1
Deng, F1
Liu, X1
Wang, X1
Gui, Y1
Qin, L1
Hu, C1
Chen, L2
Sun, Y1
Yu, X1
Zhi, Y1
Geng, S1
Li, H1
Liu, T1
Xu, K1
Wu, C1
Qi, G1
Yu, GI1
Jun, SE1
Cho, HC1
Park, KO1
Chung, JH1
Shin, DH1
Chung, IS1
Celik, O1
Ozturk, D1
Akin, F1
Satilmis, S1
Yalcin, AA1
Erturk, M1
Ayca, B1
Akturk, F1
Birand, A1
Pusuroglu, H1
Kaya, MG1
Kawada, T1
Andou, T1
Fukumitsu, M1
Li, Q1
Dong, K1
Wang, A1
Yang, X1
Zhang, C1
Zhu, Y1
Wu, S1
Zhao, X1
Li, LX1
Lu, JX1
Shuai, HP1
Xia, HF1
Wang, JW1
Chen, MY1
Li, TT1
Bao, YQ1
Jia, WP1
Saito, Y1
Nakayama, T1
Sugimoto, K1
Fujimoto, Y1
Kobayashi, Y1
Ando, K1
Takahashi, H1
Watanabe, T1
Daidoji, H1
Otaki, Y1
Nishiyama, S1
Arimoto, T1
Shishido, T1
Miyashita, T1
Miyamoto, T1
Kubota, I1
Kawasaki, M1
Lee, JH1
Kang, YS1
Jeong, YJ1
Yoon, YS1
Kwack, WG1
Oh, JY1
Iwata, A1
Miura, S1
Tanaka, T1
Ike, A1
Sugihara, M1
Nishikawa, H1
Kawamura, A1
Saku, K1
Jiang, S1
Sun, X1
Gu, H1
Chen, Y1
Xi, C1
Qiao, X1
Chen, X1

Reviews

1 review available for uric acid and Atheroma

ArticleYear
Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases.
    Clinical science (London, England : 1979), 2018, 03-30, Volume: 132, Issue:6

    Topics: Animals; Arteries; Atherosclerosis; Calcium; Crystallization; Humans; Kidney; Kidney Calculi; Lipids

2018

Trials

1 trial available for uric acid and Atheroma

ArticleYear
The Association between Serum Uric Acid Levels and the Prevalence of Vulnerable Atherosclerotic Carotid Plaque: A Cross-sectional Study.
    Scientific reports, 2015, May-11, Volume: 5

    Topics: Adult; Aged; Carotid Artery Diseases; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Pl

2015

Other Studies

23 other studies available for uric acid and Atheroma

ArticleYear
Correlation between serum uric acid levels and carotid plaque neovascularisation assessed by contrast-enhanced ultrasound.
    Clinical radiology, 2021, Volume: 76, Issue:12

    Topics: Aged; Carotid Stenosis; Cohort Studies; Female; Humans; Male; Middle Aged; Neovascularization, Patho

2021
Increased Impact of Serum Uric Acid on Arterial Stiffness and Atherosclerosis in Females.
    Journal of atherosclerosis and thrombosis, 2022, Nov-01, Volume: 29, Issue:11

    Topics: Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickness; Female; Humans; Male; Middle Aged

2022
High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Animals; Atherosclerosis; Autophagy; Ferroptosis; Hyperuricemia; Mice; NF-E2-Related Factor 2; Plaqu

2022
Birefringent crystals deposition and inflammasome expression in human atheroma plaques by levels of uricemia.
    Joint bone spine, 2022, Volume: 89, Issue:5

    Topics: Caspase 1; Ethanol; Gout; Humans; Hyperuricemia; Inflammasomes; Interleukin-1beta; NLR Family, Pyrin

2022
Correlation Between Serum Uric Acid Levels and Coronary Plaque Characteristics on Optical Coherence Tomography.
    International heart journal, 2022, Sep-30, Volume: 63, Issue:5

    Topics: Acute Coronary Syndrome; Calcinosis; Coronary Angiography; Coronary Artery Disease; Coronary Vessels

2022
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
    Journal of atherosclerosis and thrombosis, 2023, Sep-01, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Mice; Mice, Knockout; Plaque, Atherosclerotic; Uric

2023
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.
    Arteriosclerosis, thrombosis, and vascular biology, 2020, Volume: 40, Issue:3

    Topics: Adult; AMP-Activated Protein Kinases; Animals; Atherosclerosis; Benzbromarone; Biomarkers; Disease M

2020
Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients.
    Journal of diabetes research, 2017, Volume: 2017

    Topics: Adult; Blood Glucose; Calcifediol; Calcium; Carotid Artery Diseases; Carotid Intima-Media Thickness;

2017
Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study.
    BioMed research international, 2018, Volume: 2018

    Topics: Acute Coronary Syndrome; Aged; Coronary Vessels; Female; Humans; Lipids; Macrophages; Male; Middle A

2018
Very High Serum Uric Acid Levels, Plaque Morphology, and the Acute Coronary Syndrome.
    Cardiology, 2018, Volume: 141, Issue:4

    Topics: Acute Coronary Syndrome; Coronary Artery Disease; Humans; Plaque, Atherosclerotic; Tomography, Optic

2018
Serum uric acid level and subclinical coronary atherosclerosis in asymptomatic individuals: An observational cohort study.
    Atherosclerosis, 2019, Volume: 288

    Topics: Asymptomatic Diseases; Biomarkers; Computed Tomography Angiography; Coronary Angiography; Coronary A

2019
Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima-media thickness.
    Atherosclerosis, 2014, Volume: 232, Issue:1

    Topics: Adult; Aged; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Chemokine CC

2014
A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China.
    BMC cardiovascular disorders, 2014, Aug-16, Volume: 14

    Topics: Aged; Biomarkers; Chi-Square Distribution; China; Coronary Angiography; Coronary Artery Disease; Cor

2014
Association of interleukin-10 promoter region polymorphisms with risk factors of Atherosclerosis.
    International journal of immunogenetics, 2015, Volume: 42, Issue:1

    Topics: Atherosclerosis; Blood Pressure; Carotid Intima-Media Thickness; Cholesterol; Female; Homocysteine;

2015
Evaluation of lipoprotein-associated phosholipase A2 and plaque burden/composition in young adults.
    Coronary artery disease, 2015, Volume: 26, Issue:3

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adult; Age Factors; Biomarkers; C-Reactive Protein;

2015
Metabolic syndrome showed significant relationship with carotid atherosclerosis.
    Heart and vessels, 2016, Volume: 31, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Carotid Arteries; Carotid Artery Dis

2016
Decreased urine uric acid excretion is associated with diabetic retinopathy but not with lower limb atherosclerosis in hospitalized patients with type 2 diabetes.
    Atherosclerosis, 2015, Volume: 242, Issue:1

    Topics: Aged; Alcohol Drinking; Biomarkers; China; Comorbidity; Constriction, Pathologic; Cross-Sectional St

2015
Relation of Lipid Content of Coronary Plaque to Level of Serum Uric Acid.
    The American journal of cardiology, 2015, Nov-01, Volume: 116, Issue:9

    Topics: Acute Coronary Syndrome; Aged; Biomarkers; Body Mass Index; Calcinosis; Female; Hospitals, Universit

2015
Impact of Serum Uric Acid Levels on Coronary Plaque Stability Evaluated Using Integrated Backscatter Intravascular Ultrasound in Patients with Coronary Artery Disease.
    Journal of atherosclerosis and thrombosis, 2016, Aug-01, Volume: 23, Issue:8

    Topics: Aged; Coronary Artery Disease; Female; Humans; Image Interpretation, Computer-Assisted; Japan; Male;

2016
Tissue Characterization of Coronary Plaques as a Key to Relationship between Serum Uric Acid Level and Cardiovascular Disease: A Direct Risk or an Indirect Marker?
    Journal of atherosclerosis and thrombosis, 2016, Aug-01, Volume: 23, Issue:8

    Topics: Biomarkers; Cardiovascular Diseases; Humans; Plaque, Atherosclerotic; Tissue Distribution; Ultrasono

2016
Relationship between FEV1 and Cardiovascular Risk Factors in General Population without Airflow Limitation.
    Canadian respiratory journal, 2016, Volume: 2016

    Topics: Adult; Age Factors; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Carotid Artery Dise

2016
Plasma pentraxin-3 levels are associated with coronary plaque vulnerability and are decreased by statin.
    Coronary artery disease, 2012, Volume: 23, Issue:5

    Topics: Aged; Angina, Stable; Atorvastatin; Biomarkers; C-Reactive Protein; Case-Control Studies; Chi-Square

2012
Age-related change in kidney function, its influencing factors, and association with asymptomatic carotid atherosclerosis in healthy individuals--a 5-year follow-up study.
    Maturitas, 2012, Volume: 73, Issue:3

    Topics: Age Factors; Aged; Aging; Blood Pressure; Carotid Artery Diseases; China; Cholesterol, LDL; Cross-Se

2012