uric acid has been researched along with Apoplexy in 198 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of serum uric acid as a factor in the recurrence of ischemic stroke stays unclear." | 9.41 | Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis. ( Gao, Y; Li, M; Wang, H, 2023) |
| "To investigate the association of baseline serum uric acid (UA) with new-onset diabetes, and to explore the possible effect modifiers in Chinese adults with hypertension." | 9.34 | Positive association of serum uric acid with new-onset diabetes in Chinese women with hypertension in a retrospective analysis of the China Stroke Primary Prevention Trial. ( Hu, W; Liang, M; Liu, C; Liu, L; Liu, M; Nie, J; Qin, X; Song, Y; Wang, B; Wang, X; Xu, X; Zhang, Y; Zhang, Z; Zhou, C, 2020) |
| "Uric acid (UA) is a promising protective treatment in ischaemic stroke, but the precise molecular targets underlying its in vivo beneficial actions remain unclear." | 9.30 | Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension. ( Amaro, S; Chamorro, Á; D'Ocon, P; Dantas, AP; Jiménez-Altayó, F; Masip, N; Planas, AM; Puertas-Umbert, L; Solé, M; Unzeta, M; Vila, E, 2019) |
| "We sought to assess a consecutive number of patients with first-ever acute ischemic stroke (AIS), the clinical relevance in regard to functional outcome of the serum uric acid (SUA) measured at admission." | 9.27 | U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke. ( Ding, L; Li, Y; Sheng, L; Wen, C; Xie, Z; Yang, Y; Zhang, Y, 2018) |
| "Serum uric acid (UA) has been suggested to be correlated with outcomes after stroke." | 9.22 | Uric Acid and Cognitive Impairment in Patients with Acute Ischemic Stroke: A Meta-Analysis. ( Jin, X; Ren, Z; Wang, Y; Wen, Q; Yan, X; Zhang, W, 2022) |
| "The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke remains debatable in human studies, and the sex effect on this association has yet to be explored." | 9.22 | Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial. ( Chen, LH; Geng, D; He, J; Ju, Z; Li, Q; Li, Y; Peng, H; Peng, Y; Wang, A; Wang, J; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2016) |
| "A study was undertaken to test in a subgroup reanalysis of the URICO-ICTUS trial whether uric acid is superior to placebo in improving the functional outcome in patients with acute stroke and hyperglycemia." | 9.20 | Uric acid improves glucose-driven oxidative stress in human ischemic stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Perez, B; Planas, AM; Renú, A; Torres, F; Vila, E, 2015) |
| "In the Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke (URICO-ICTUS) trial, 206 women and 205 men were randomized to UA 1000 mg or placebo." | 9.20 | Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Obach, V; Pérez, B; Planas, A; Renú, A; Urra, X; Vila, E, 2015) |
| "Uric acid is an antioxidant with neuroprotective effects in experimental models of stroke." | 9.19 | Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial. ( Amaro, S; Arenillas, J; Cánovas, D; Carné, X; Castellanos, M; Chamorro, A; Deulofeu, R; Gállego, J; Gomis, M; Krupinski, J; Martí-Fábregas, J; Oleaga, L; Planas, AM; Román, LS; Segura, T; Torres, F, 2014) |
| "To determine whether the combined treatment with uric acid and rtPA is superior to rtPA alone in terms of clinical efficacy in acute ischaemic stroke patients treated within the first 4." | 9.14 | The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms. ( Amaro, S; Cánovas, D; Castellanos, M; Chamorro, A; Gállego, J; Martí-Fèbregas, J; Segura, T, 2010) |
| "Studies on the association of uric acid with mortality and cardiovascular outcomes in patients with hypertension have produced contradictory results." | 9.12 | Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis. ( Jin, Z; Yang, Y; Zhang, X; Zhao, Q, 2021) |
| "Serum uric acid independently predicts cardiovascular events in older persons with isolated systolic hypertension." | 9.09 | Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). ( Applegate, WB; Di Bari, M; Franse, LV; Pahor, M; Shorr, RI; Somes, GW; Wan, JY, 2000) |
| "The issue of whether serum uric acid (SUA) is associated with the outcome of acute ischemic stroke is controversial." | 9.01 | Serum Uric Acid Level and Outcome of Patients With Ischemic Stroke: A Systematic Review and Meta-Analysis. ( Cai, J; Hong, H; Lei, Z; Wang, Y, 2019) |
| "Conflicting findings of the association between serum uric acid (UA) and stroke have been reported in both men and women, and it is unclear whether this association was different between men and women." | 8.95 | Sex-Specific Relationship Between Serum Uric Acid and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies. ( Xu, T; Zhang, Y; Zhong, C; Zhong, X, 2017) |
| "Previous studies assessing the association between serum uric acid levels and neurological outcome after acute ischemic stroke reported conflicting results." | 8.93 | Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke. ( Chen, Y; Li, C; Lin, Y; Liu, Y; Wang, B; Wang, Y; Wang, Z; Yan, S; Zhao, W, 2016) |
| "Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke." | 8.91 | The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature. ( Chen, J; Guo, Y; Huang, C; Li, R; Tan, S, 2015) |
| "Results from the recent meta-analysis suggested that higher serum uric acid (SUA) levels are positively associated with risk of stroke." | 8.90 | Dose-response relationship of serum uric acid levels with risk of stroke mortality. ( Hu, D; Huang, J; Qu, Y; Wang, Y; Zhang, D, 2014) |
| "Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and stroke, the issue remains unresolved and it is not clear whether the correlation between uric acid and stroke is circumstantial or causal." | 8.84 | The role of uric acid in stroke: the issue remains unresolved. ( Dimitroula, HV; Hatzitolios, AI; Karvounis, HI, 2008) |
| "The relationship between serum uric acid (SUA) and poor cognitive performance in patients with ischemic stroke is unclear." | 8.31 | The association between serum uric acid and cognitive performance in patients with ischemic stroke is modified by estimated glomerular filtration rate. ( Bai, B; Gao, H; Li, D; Meng, P; Zhang, C; Zhang, X, 2023) |
| "The validity of high uric acid levels as an independent cause of stroke remains controversial, and the association between its low concentration and stroke is unclear." | 8.31 | Association of serum uric acid with risk of stroke in US adults: A cross-sectional study from NHANES 1999-2020. ( Bao, Y; Gao, B; Liang, X; Lu, Y; Meng, M; Sa, R; Shi, J; Yu, L, 2023) |
| "Evidence on the longitudinal associations between serum uric acid (SUA) and stroke was limited and yielded inconsistent conclusions." | 8.31 | Cumulative Serum Uric Acid Exposure and Its Time Course With the Risk of Incident Stroke. ( Chen, S; Luo, Y; Tian, X; Wang, A; Wang, P; Wu, S; Xu, Q; Zhang, X; Zhang, Y, 2023) |
| "We analyzed 4,621 acute ischemic stroke patients enrolled in the Fukuoka Stroke Registry between June 2007 and September 2019 whose uric acid levels were measured at least twice during hospitalization (including on admission)." | 8.31 | Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study. ( Ago, T; Irie, F; Kamouchi, M; Kitazono, T; Kiyohara, T; Matsuo, R; Nakamura, K; Ueki, K; Wakisaka, Y, 2023) |
| " This study aimed to explore the relationship between total bilirubin-to-uric acid ratio (TUR) and sleep quality after acute ischemic stroke (AIS)." | 8.31 | High total bilirubin-to-uric acid ratio predicts poor sleep quality after acute ischemic stroke: a prospective nested case-control study. ( Chen, J; Geng, D; He, J; Lin, Y; Liu, Y; Tang, W; Wu, B, 2023) |
| "Assessment and prognostic value of serum uric acid (SUA) and neuron-specific enolase (NSE) on the efficacy of intravenous thrombolytic therapy in cerebral infarction." | 8.31 | Assessment and prognostic value of serum uric acid and neuron-specific enolase on the efficacy of intravenous thrombolytic therapy in cerebral infarction. ( Liu, S; Shi, Y; Wang, S; Zang, Y; Zheng, H, 2023) |
| "The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting combined (fatal and non-fatal) cerebrovascular (CBV) events in the whole database." | 8.12 | Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'elia, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Salvetti, M; Spinella, P; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2022) |
| "It is not clear whether serum uric acid (SUA) levels and their changes over time are associated with the risk of stroke." | 8.12 | Serum Uric Acid Levels and Their Changes and Risk of Stroke: A 7-Year Prospective Cohort Study in Northwest China. ( Bai, Y; Cheng, Z; Liu, Y; Luo, Y; Lv, K; Miao, Q; Wang, M; Yin, C; Zhang, D; Zheng, S, 2022) |
| "The role of serum uric acid (SUA) in stroke remains controversial and analyses of changes in SUA and stroke are limited." | 8.12 | Effect of changes in serum uric acid on the risk of stroke and its subtypes. ( Chen, S; Luo, Y; Mo, D; Tian, X; Wang, A; Wang, Y; Wu, S; Zhang, L; Zuo, Y, 2022) |
| "Previous studies have found that uric acid (UA) plays a neuroprotective role in ischemic stroke patients." | 8.12 | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke. ( Li, X; Ma, A; Pan, X; Wei, J; Yin, R, 2022) |
| " Whereas Serum Uric acid acts as a marker of tissue infarction; indicating poor prognosis of ischemic stroke." | 8.12 | A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke. ( Bc, PK; Somannavar, VG, 2022) |
| "Higher serum levels of homocysteine, CRP, and Pro-BNP are associated with a higher risk of acute ischemic stroke." | 8.12 | Role of Serum Homocysteine, C-Reactive Protein (CRP), Uric Acid & Pro-Brain Natriuretic Peptide (Pro-BNP) in Predicting the Functional Outcome in Patients with Ischemic Stroke- A Prospective Observational Study from North India. ( Atam, V; Chauhan, H; Reddy, DH; Sawlani, KK, 2022) |
| "The role of uric acid as a risk factor for cerebrovascular disease, particularly acute ischemic stroke, is controversial and there is little information about this in our setting." | 8.12 | Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh. ( Hossain, MS; Jasmine, T; Kamrul-Hasan, AB; Rahman, MM; Saha, PK; Sarker, MA, 2022) |
| "BACKGROUND Serum uric acid (UA) is involved in the development of hypertension." | 8.02 | U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study. ( Chen, K; Han, P; You, H; Yue, C; Zhao, X, 2021) |
| "Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT)." | 8.02 | Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke. ( Chen, S; Cheng, Q; Dai, Y; Fan, K; He, J; Hu, J; Huang, G; Huang, Q; Liu, Y; Ren, W; Wang, L; Wu, C; Xu, M; Xu, R; Xue, L; Yan, F; Zhang, W; Zhu, Z, 2021) |
| "Uric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models." | 7.96 | Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke. ( Cheng, Y; Liu, J; Liu, M; Song, Q; Wang, Y; Wei, C, 2020) |
| "The role of serum uric acid as a predictor of stroke among the general Japanese population remains controversial." | 7.96 | Serum uric acid and risk of stroke and its types: the Circulatory Risk in Communities Study (CIRCS). ( Cui, R; Hayama-Terada, M; Imano, H; Iso, H; Kitamura, A; Kiyama, M; Li, J; Muraki, I; Ohira, T; Okada, T; Sankai, T; Tanigawa, T; Umesawa, M; Yamagishi, K, 2020) |
| "According to the results of this study, uric acid medians in patients with stroke and controls were 4." | 7.96 | Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke. ( Ahmadi, Z; Amirabadizadeh, A; Mousavi-Mirzaei, SM; Nakhaee, S; Talebi, A, 2020) |
| " Previous studies have shown that high serum uric acid (SUA) levels are an independent risk factor for hypertension, cardiovascular disease (CVD), and ischemic stroke." | 7.96 | Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis. ( Bai, CX; Chen, JZ; Ge, J; Hui, RT; Li, H; Liu, TL; Song, L; Song, WH; Sun, YY; Wen, HY; Xiao, N; Xu, HC; Zhang, YH, 2020) |
| "Increased level of serum uric acid (SUA) is often considered a risk factor for ischemic stroke." | 7.96 | Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh. ( Al Mamun, MA; Barman, N; Haque, MA; Khalil, MI; Salwa, M; Sultana, S, 2020) |
| "The role of serum uric acid in ischemic stroke is controversial." | 7.91 | Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles Pérez-Monteoliva, NR, 2019) |
| "This study investigated the association between serum uric acid (sUA) and stroke risk in men with hypertriglyceridemia." | 7.91 | Is serum uric acid a predictive factor for stroke in men with hypertriglyceridemia? ( Hsu, CY; Lai, YJ, 2019) |
| "Uric acid has gained considerable attention as a potential neuroprotective agent in stroke during the last decades, however, its role in the pathophysiology of ischemic stroke remains poorly understood." | 7.91 | Relationship between infarct size and serum uric acid levels during the acute phase of stroke. ( Bustamante, G; Cavada, G; Cortés-Fuentes, IA; Fernández-Gajardo, R; Feuerhake, W; Guerrero, R; Gutiérrez, R; Lozano, P; Matamala, JM; Pasten, JA; Reyes, P; Rodrigo, R; Sotomayor, CG; Vargas, G, 2019) |
| "This was a hospital-based prospective cohort study that included patients with ischemic stroke with baseline uric acid levels and 3-month post-stroke follow-up data." | 7.88 | The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans. ( Ayeah, CM; Ba, H; Hentchoya, R; Luma, HN; Mapoure, YN, 2018) |
| "The relationship between serum uric acid (SUA) levels and stroke is controversial." | 7.88 | Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles, NR, 2018) |
| "Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke." | 7.88 | High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke. ( Lai, R; Li, JX; Sheng, WL; Sun, XS; Wang, YF, 2018) |
| "Uric acid (UA), an antioxidant with neuroprotective effects, favorably affects stroke outcome." | 7.88 | Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone. ( Ando, Y; Inatomi, Y; Naganuma, M; Nakajima, M; Yonehara, T, 2018) |
| "Preclinical and clinical studies support a promising, albeit not definitive, neuroprotective effect of emergent uric acid (UA) administration in ischemic stroke." | 7.88 | Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats. ( Aliena-Valero, A; Burguete, MC; Castelló-Ruiz, M; Chamorro, Á; Hervás, D; Jover-Mengual, T; Leira, EC; López-Morales, MA; Salom, JB; Torregrosa, G, 2018) |
| "Uric acid is a molecule that is known to act as a natural antioxidant in acute oxidative stress conditions such as acute ischemic stroke (AIS)." | 7.88 | Can high uric acid levels be an independent risk factor for acute ischemic stroke due to large-artery atherosclerosis? ( Acar, AB; Acar, T; Gül, SS; Güzey Aras, Y, 2018) |
| "Our aim was to investigate the association between serum uric acid (SUA) levels and the risk of first stroke in a Chinese population of hypertensive patients." | 7.85 | Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort. ( Cai, Y; Dong, Q; Fu, J; He, M; Huo, Y; Li, J; Qin, X; Shi, X; Tang, G; Wang, B; Wang, K; Wang, L; Xu, X; Yang, J; Zhang, C; Zhang, Y; Zhao, G; Zhao, M, 2017) |
| "An association between serum uric acid and outcomes of ischemic stroke has been reported, but the results are controversial." | 7.85 | Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke. ( Fukuda, H; Kawase, S; Kowa, H; Kusumi, M; Nakashima, K; Nakayasu, H; Suto, Y, 2017) |
| " This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population." | 7.85 | Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study. ( Asahi, K; Fujimoto, S; Hirayama, A; Ichikawa, K; Iseki, K; Kamei, K; Kasahara, M; Kondo, M; Konta, T; Kubota, I; Moriyama, T; Narita, I; Shibagaki, Y; Tsuruya, K; Watanabe, T; Yamagata, K, 2017) |
| "Conflicting results on the correlation between hyperuricemia and the prognosis of stroke had been reported and the close association between serum uric acid (SUA) and abnormal glycomatabolism might further complicate the assessment of the correlation." | 7.85 | Lower serum uric acid level strongly predict short-term poor functional outcome in acute stroke with normoglycaemia: a cohort study in China. ( Jun, WY; Pan, Y; Wang, C; Wu, S; Zhang, N, 2017) |
| "The importance and function of serum uric acid (UA) levels in patients with cardiovascular disease or stroke are unclear." | 7.83 | Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients. ( Cao, YJ; Huang, ZC; Liu, CF; Lu, TS; You, SJ; Zhang, X, 2016) |
| "In matched analysis, risk of ischaemic stroke increased by 15% for each 1 mg/dl increase in plasma uric acid [95% confidence interval (CI) 3%-28%], but was no longer significant after adjustment for cardiovascular risk factors, particularly history of hypertension." | 7.83 | Plasma uric acid concentrations and risk of ischaemic stroke in women. ( Choi, HK; Curhan, GC; Forman, JP; Jiménez, MC; Rexrode, KM, 2016) |
| "Although high uric acid levels have been reported to be a risk factor for cardiovascular disease and stroke, the relationship between serum uric acid (SUA) levels and cardioembolic stroke (CES) has not been fully elucidated." | 7.83 | Association of serum uric acid and cardioembolic stroke in patients with acute ischemic stroke. ( Jung, S; Kim, CK; Kim, TJ; Kim, Y; Lee, SH; Yang, XL, 2016) |
| "No evidence is currently provided on the involvement of uric acid (UA) and Cu/Zn Superoxide Dismutase (Cu/Zn SOD) in functional recovery of stroke patients after neurorehabilitation." | 7.81 | Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation. ( Ciancarelli, I; De Amicis, D; Di Massimo, C; Pistarini, C; Tozzi Ciancarelli, MG, 2015) |
| "Exogenous uric acid (UA) is a neuroprotective antioxidant that reinforces the benefits of intravenous recombinant tissue plasminogen activator thrombolysis in animal thromboembolic stroke." | 7.81 | Serum uric acid is neuroprotective in Chinese patients with acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator. ( Chen, M; Ge, QM; Liu, M; Liu, X; Pan, SM, 2015) |
| "To evaluate the relation of serum uric acid levels on admission with short-term clinical outcome and hemorrhagic transformation (HT) in patients with acute ischemic stroke treated with thrombolysis." | 7.81 | [Association study of serum uric acid levels with clinical outcome and hemorrhagic transformation in stroke patients with rt-PA intravenous thrombolysis]. ( Cao, Y; Jiang, C; Liu, C; Shi, J; Xu, J; You, S; Yu, X, 2015) |
| "The relationship between uric acid and stroke prognosis is ambiguous." | 7.80 | Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patients. ( Jia, Q; Liu, G; Liu, L; Pu, Y; Wang, C; Wang, Y; Wu, H; Zhao, X, 2014) |
| "Between 2009 and 2012, we conducted a study among 406 consecutive first-ever ischemic stroke patients to assess the relationship between uric acid and carotid artery." | 7.80 | Association of uric acid and carotid artery disease in patients with ischemic stroke. ( Kabaroglu, C; Karaman, B; Kumral, E; Orman, M, 2014) |
| "To clarify the correlation of fatigue during the acute stage of stroke with serum uric acid (UA) and glucose levels, depression, and disability." | 7.80 | Correlation of fatigue during the acute stage of stroke with serum uric acid and glucose levels, depression, and disability. ( Huang, K; Shang, X; Teng, W; Wang, L; Wu, D, 2014) |
| "Current evidence shows that uric acid is a potent antioxidant whose serum concentration increases rapidly after acute ischemic stroke (AIS)." | 7.79 | Serum uric acid and outcome after acute ischemic stroke: PREMIER study. ( Arauz, A; Barinagarrementeria, F; Cantú-Brito, C; Chiquete, E; León-Jiménez, C; Murillo-Bonilla, LM; Ochoa-Guzmán, A; Orozco-Valera, DR; Ramos-Moreno, A; Ruiz-Sandoval, JL; Villarreal-Careaga, J, 2013) |
| "Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke." | 7.79 | Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke. ( Kim, BJ; Kim, CK; Lee, SH; Ryu, WS, 2013) |
| "The prognostic value of serum uric acid (UA) in acute ischemic stroke is controversial." | 7.78 | Lack of association between serum uric acid levels and outcome in acute ischemic stroke. ( de Keyser, J; Koch, M; Kremer, B; Luijckx, GJ; Miedema, I; Uyttenboogaart, M, 2012) |
| "To investigate the association between serum uric acid (SUA) and early clinical outcome among patients with acute stroke." | 7.78 | [Association between serum uric acid and short-term clinical outcome among patients with acute stroke]. ( Peng, Y; Xu, Y; Zhang, JT; Zhang, XL; Zhang, YH, 2012) |
| "Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population." | 7.77 | Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients. ( Chen, Y; Ding, X; Fang, Y; Liu, Z; Shen, B; Teng, J; Wang, Y; Xu, S; Zhong, Y; Zou, J, 2011) |
| " Mortality from all causes, total cardiovascular disease (CVD), ischemic stroke, congestive heart failure, hypertensive disease, and coronary heart disease were compared according to increasing serum uric acid levels." | 7.75 | Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. ( Chen, HJ; Chen, JH; Chuang, SY; Pan, WH; Yeh, WT, 2009) |
| "Few studies have simultaneously analysed the influence of elevated serum uric acid (UA) on acute myocardial infarction (AMI), ischaemic and haemorrhagic stroke (IS, HS) and congestive heart failure (CHF) in large healthy populations." | 7.75 | Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). ( Aastveit, AH; Hammar, N; Holme, I; Jungner, I; Walldius, G, 2009) |
| "Bilirubin (Bil) and uric acid (UA) are the endogenous antioxidant compounds possibly involved in the pathogenesis of ischemic stroke (IS)." | 7.75 | Serum bilirubin and uric acid levels as the bad prognostic factors in the ischemic stroke. ( Bartosik-Psujek, H; Bielewicz, J; Kurzepa, J; Stelmasiak, Z, 2009) |
| "The prognostic significance of uric acid (UA) levels in acute stroke is unclear, so the objective of this study was to determine the association between levels of serum UA (SUA) and mortality in acute stroke." | 7.74 | Serum uric acid as an independent predictor of early death after acute stroke. ( Athyros, VG; Gossios, T; Kakafika, A; Karagiannis, A; Krikis, N; Mikhailidis, DP; Moschou, I; Savvatianos, S; Sileli, M; Tziomalos, K; Xochellis, M, 2007) |
| "Since serum uric acid (UA) is strongly associated with cardiovascular risk factors, it has been debated whether serum UA is a stroke risk factor or whether UA may be simply "marking" subjects with other, causal risk factors." | 7.73 | Serum uric acid and risk of ischemic stroke: the ARIC Study. ( Folsom, AR; Hozawa, A; Ibrahim, H; Nieto, FJ; Rosamond, WD; Shahar, E, 2006) |
| "The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke." | 7.73 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. ( Bos, MJ; Breteler, MM; Hofman, A; Koudstaal, PJ; Witteman, JC, 2006) |
| "Uric acid is the end product of purine metabolism and a powerful water-soluble antioxidant and radical scavenger in humans whose generation is increased in situations of oxidative stress, such as brain ischemia." | 7.72 | Uric acid administration for neuroprotection in patients with acute brain ischemia. ( Chamorro, A; Deulofeu, R; Muner, DS; Planas, AM, 2004) |
| "Male type 2 diabetic patients with stroke had significantly higher mean levels of serum uric acid than simple diabetic patients, but such patients of both genders all had lower HDL levels." | 7.71 | [Serum uric acid in type 2 diabetic patients complicated by stroke]. ( Gao, F; Guan, MP; Li, CZ; Liu, SQ; Shen, J; Xue, YM; Zhou, L, 2002) |
| "We sought to assess in 881 consecutive patients with acute ischemic stroke the clinical relevance in regard to functional outcome of the natural antioxidant uric acid measured at hospital admission." | 7.71 | Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. ( Aponte, JH; Cervera, A; Chamorro, A; Deulofeu, R; Obach, V; Revilla, M, 2002) |
| "Uric acid is an endogenous antioxidant making it a drug candidate to improve stroke outcomes." | 6.84 | Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy. ( Amaro, S; Arenillas, JF; Blasco, J; Cánovas, D; Castellanos, M; Chamorro, Á; Gomis, M; Leira, EC; Macho, J; Marti-Fabregas, J; Muñoz, R; Planas, AM; Román, LS; Urra, X, 2017) |
| "Calcium antagonists are used in the treatment of hypertension and angina." | 6.44 | The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension. ( Coca, A; Sierra, C, 2008) |
| "Uric acid was the leading metabolite in univariate analysis of both hyperglycemia (OR 19." | 5.62 | Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke. ( Acharjee, A; Ament, Z; Bevers, MB; Kimberly, WT; Wolcott, Z, 2021) |
| "Uric acid (UA) is an important endogenous free radical scavenger that has been found to have a neuroprotective effect." | 5.62 | Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy. ( Cui, T; Hao, Z; Wang, A; Wang, C; Wang, L; Wu, B; Yuan, Y; Zhu, Q, 2021) |
| "Allopurinol is a urate-lowering therapy used to treat patients with gout." | 5.51 | Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial. ( Avery, AJ; Barr, RJ; Begg, AG; Duce, SL; Dumbleton, JS; Ford, I; Greenlaw, N; Hawkey, CJ; MacDonald, TM; Mackenzie, IS; Pigazzani, F; Ritchie, LD; Rogers, A; Rooke, ED; Struthers, AD; Taggar, JS; Townend, JN; Walker, A; Wei, L, 2022) |
| "Uric acid has neuroprotective properties in experimental and clinical studies of neurodegenerative disease." | 5.48 | Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke. ( Liu, H; Reynolds, GP; Wang, W; Wei, X, 2018) |
| "Uric acid (UA) plays an important role in the oxidant stress that causes inflammation." | 5.43 | Association of uric acid with traditional inflammatory factors in stroke. ( Xiong, G; Zhang, J; Zhu, A; Zou, T, 2016) |
| "Uric acid level was elevated in ischemic stroke than haemorrhagic stroke patients (p<0." | 5.43 | Serum Uric Acid Level among Acute Stroke Patients. ( Bhuiyan, AS; Chowdhury, M; Das, BR; Das, SN; Haque, MF; Jahan, MK; Mohsin, M; Rahman, MM; Saha, PL; Shikha, SS, 2016) |
| "The role of serum uric acid as a factor in the recurrence of ischemic stroke stays unclear." | 5.41 | Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis. ( Gao, Y; Li, M; Wang, H, 2023) |
| "Uric acid (UA) is a strong endogenous antioxidant that neutralizes the toxicity of peroxynitrite and other reactive species on the neurovascular unit generated during and after acute brain ischemia." | 5.41 | Uric Acid: A Translational Journey in Cerebroprotection That Spanned Preclinical and Human Data. ( Chamorro, A; Chauhan, AK; Leira, EC; Planas, AM, 2023) |
| "Uric acid (UA) has been known to be a neuroprotective antioxidant because of its free radical scavenger activity." | 5.40 | Effects of uric acid levels on outcome in severe ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator. ( Chang, DI; Heo, SH; Kim, HY; Kim, JH; Kim, YS; Koh, SH; Lee, D; Lee, JS; Lee, SH, 2014) |
| "To investigate the association of baseline serum uric acid (UA) with new-onset diabetes, and to explore the possible effect modifiers in Chinese adults with hypertension." | 5.34 | Positive association of serum uric acid with new-onset diabetes in Chinese women with hypertension in a retrospective analysis of the China Stroke Primary Prevention Trial. ( Hu, W; Liang, M; Liu, C; Liu, L; Liu, M; Nie, J; Qin, X; Song, Y; Wang, B; Wang, X; Xu, X; Zhang, Y; Zhang, Z; Zhou, C, 2020) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 5.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "Uric acid (UA) is a promising protective treatment in ischaemic stroke, but the precise molecular targets underlying its in vivo beneficial actions remain unclear." | 5.30 | Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension. ( Amaro, S; Chamorro, Á; D'Ocon, P; Dantas, AP; Jiménez-Altayó, F; Masip, N; Planas, AM; Puertas-Umbert, L; Solé, M; Unzeta, M; Vila, E, 2019) |
| " We report a post hoc analysis of the URICO-ICTUS trial (NCT00860366) assessing the modifying treatment effect of pretreatment collaterals on clinical and radiological outcomes in patients with large-vessel acute ischemic stroke receiving uric acid therapy or placebo." | 5.30 | Relevance of Collaterals for the Success of Neuroprotective Therapies in Acute Ischemic Stroke: Insights from the Randomized URICO-ICTUS Trial. ( Amaro, S; Arenillas, JF; Castellanos, M; Chamorro, Á; Laredo, C; Llull, L; Obach, V; Renú, A; Rudilloso, S; Urra, X, 2019) |
| "We sought to assess a consecutive number of patients with first-ever acute ischemic stroke (AIS), the clinical relevance in regard to functional outcome of the serum uric acid (SUA) measured at admission." | 5.27 | U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke. ( Ding, L; Li, Y; Sheng, L; Wen, C; Xie, Z; Yang, Y; Zhang, Y, 2018) |
| "Serum uric acid (UA) has been suggested to be correlated with outcomes after stroke." | 5.22 | Uric Acid and Cognitive Impairment in Patients with Acute Ischemic Stroke: A Meta-Analysis. ( Jin, X; Ren, Z; Wang, Y; Wen, Q; Yan, X; Zhang, W, 2022) |
| "The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke remains debatable in human studies, and the sex effect on this association has yet to be explored." | 5.22 | Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial. ( Chen, LH; Geng, D; He, J; Ju, Z; Li, Q; Li, Y; Peng, H; Peng, Y; Wang, A; Wang, J; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2016) |
| "A study was undertaken to test in a subgroup reanalysis of the URICO-ICTUS trial whether uric acid is superior to placebo in improving the functional outcome in patients with acute stroke and hyperglycemia." | 5.20 | Uric acid improves glucose-driven oxidative stress in human ischemic stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Perez, B; Planas, AM; Renú, A; Torres, F; Vila, E, 2015) |
| "In the Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke (URICO-ICTUS) trial, 206 women and 205 men were randomized to UA 1000 mg or placebo." | 5.20 | Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke. ( Amaro, S; Chamorro, Á; Laredo, C; Llull, L; Obach, V; Pérez, B; Planas, A; Renú, A; Urra, X; Vila, E, 2015) |
| "Uric acid is an antioxidant with neuroprotective effects in experimental models of stroke." | 5.19 | Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial. ( Amaro, S; Arenillas, J; Cánovas, D; Carné, X; Castellanos, M; Chamorro, A; Deulofeu, R; Gállego, J; Gomis, M; Krupinski, J; Martí-Fábregas, J; Oleaga, L; Planas, AM; Román, LS; Segura, T; Torres, F, 2014) |
| "To determine whether the combined treatment with uric acid and rtPA is superior to rtPA alone in terms of clinical efficacy in acute ischaemic stroke patients treated within the first 4." | 5.14 | The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms. ( Amaro, S; Cánovas, D; Castellanos, M; Chamorro, A; Gállego, J; Martí-Fèbregas, J; Segura, T, 2010) |
| "Studies on the association of uric acid with mortality and cardiovascular outcomes in patients with hypertension have produced contradictory results." | 5.12 | Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis. ( Jin, Z; Yang, Y; Zhang, X; Zhao, Q, 2021) |
| "We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-alpha and interleukin-1beta, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF2alpha) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects." | 5.11 | Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. ( Dashe, JF; Folstein, MF; Martin, A; Sánchez-Moreno, C; Scott, T; Thaler, D, 2004) |
| "To examine the relationship between raised serum uric acid and subsequent cardiovascular events (mortality, myocardial infarction, stroke)." | 5.09 | Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans? ( Longo-Mbenza, B; Luila, EL; Mbete, P; Vita, EK, 1999) |
| "Serum uric acid independently predicts cardiovascular events in older persons with isolated systolic hypertension." | 5.09 | Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). ( Applegate, WB; Di Bari, M; Franse, LV; Pahor, M; Shorr, RI; Somes, GW; Wan, JY, 2000) |
| "The issue of whether serum uric acid (SUA) is associated with the outcome of acute ischemic stroke is controversial." | 5.01 | Serum Uric Acid Level and Outcome of Patients With Ischemic Stroke: A Systematic Review and Meta-Analysis. ( Cai, J; Hong, H; Lei, Z; Wang, Y, 2019) |
| "Conflicting findings of the association between serum uric acid (UA) and stroke have been reported in both men and women, and it is unclear whether this association was different between men and women." | 4.95 | Sex-Specific Relationship Between Serum Uric Acid and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies. ( Xu, T; Zhang, Y; Zhong, C; Zhong, X, 2017) |
| "Previous studies assessing the association between serum uric acid levels and neurological outcome after acute ischemic stroke reported conflicting results." | 4.93 | Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke. ( Chen, Y; Li, C; Lin, Y; Liu, Y; Wang, B; Wang, Y; Wang, Z; Yan, S; Zhao, W, 2016) |
| "Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke." | 4.91 | The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature. ( Chen, J; Guo, Y; Huang, C; Li, R; Tan, S, 2015) |
| "Results from the recent meta-analysis suggested that higher serum uric acid (SUA) levels are positively associated with risk of stroke." | 4.90 | Dose-response relationship of serum uric acid levels with risk of stroke mortality. ( Hu, D; Huang, J; Qu, Y; Wang, Y; Zhang, D, 2014) |
| " Prospective cohort studies were included only if they contained data on stroke incidences or mortalities related to serum uric acid levels in adults." | 4.85 | Hyperuricemia and risk of stroke: a systematic review and meta-analysis. ( Albert, DA; Choi, HK; Guevara, JP; Heitjan, DF; Kim, KM; Kim, SY, 2009) |
| "Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and stroke, the issue remains unresolved and it is not clear whether the correlation between uric acid and stroke is circumstantial or causal." | 4.84 | The role of uric acid in stroke: the issue remains unresolved. ( Dimitroula, HV; Hatzitolios, AI; Karvounis, HI, 2008) |
| "The relationship between serum uric acid (SUA) and poor cognitive performance in patients with ischemic stroke is unclear." | 4.31 | The association between serum uric acid and cognitive performance in patients with ischemic stroke is modified by estimated glomerular filtration rate. ( Bai, B; Gao, H; Li, D; Meng, P; Zhang, C; Zhang, X, 2023) |
| "The validity of high uric acid levels as an independent cause of stroke remains controversial, and the association between its low concentration and stroke is unclear." | 4.31 | Association of serum uric acid with risk of stroke in US adults: A cross-sectional study from NHANES 1999-2020. ( Bao, Y; Gao, B; Liang, X; Lu, Y; Meng, M; Sa, R; Shi, J; Yu, L, 2023) |
| "Evidence on the longitudinal associations between serum uric acid (SUA) and stroke was limited and yielded inconsistent conclusions." | 4.31 | Cumulative Serum Uric Acid Exposure and Its Time Course With the Risk of Incident Stroke. ( Chen, S; Luo, Y; Tian, X; Wang, A; Wang, P; Wu, S; Xu, Q; Zhang, X; Zhang, Y, 2023) |
| "We analyzed 4,621 acute ischemic stroke patients enrolled in the Fukuoka Stroke Registry between June 2007 and September 2019 whose uric acid levels were measured at least twice during hospitalization (including on admission)." | 4.31 | Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study. ( Ago, T; Irie, F; Kamouchi, M; Kitazono, T; Kiyohara, T; Matsuo, R; Nakamura, K; Ueki, K; Wakisaka, Y, 2023) |
| " This study aimed to explore the relationship between total bilirubin-to-uric acid ratio (TUR) and sleep quality after acute ischemic stroke (AIS)." | 4.31 | High total bilirubin-to-uric acid ratio predicts poor sleep quality after acute ischemic stroke: a prospective nested case-control study. ( Chen, J; Geng, D; He, J; Lin, Y; Liu, Y; Tang, W; Wu, B, 2023) |
| "Assessment and prognostic value of serum uric acid (SUA) and neuron-specific enolase (NSE) on the efficacy of intravenous thrombolytic therapy in cerebral infarction." | 4.31 | Assessment and prognostic value of serum uric acid and neuron-specific enolase on the efficacy of intravenous thrombolytic therapy in cerebral infarction. ( Liu, S; Shi, Y; Wang, S; Zang, Y; Zheng, H, 2023) |
| "05 included blood pressure, uric acid, glucose level, triglyceride level, total cholesterol level, homocysteine level, duration of disease, and cerebral infarction site." | 4.31 | Factors influencing TCM syndrome types of acute cerebral infarction: A binomial logistic regression analysis. ( Yang, J; Zhang, S, 2023) |
| "The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting combined (fatal and non-fatal) cerebrovascular (CBV) events in the whole database." | 4.12 | Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study. ( Barbagallo, CM; Bombelli, M; Borghi, C; Casiglia, E; Cicero, AFG; Cirillo, M; Cirillo, P; D'elia, L; Desideri, G; Ferri, C; Galletti, F; Gesualdo, L; Giannattasio, C; Grassi, G; Iaccarino, G; Mallamaci, F; Maloberti, A; Masi, S; Mazza, A; Muiesan, ML; Nazzaro, P; Palatini, P; Parati, G; Pontremoli, R; Quarti-Trevano, F; Rattazzi, M; Rivasi, G; Salvetti, M; Spinella, P; Tikhonoff, V; Tocci, G; Ungar, A; Verdecchia, P; Viazzi, F; Virdis, A; Volpe, M, 2022) |
| "It is not clear whether serum uric acid (SUA) levels and their changes over time are associated with the risk of stroke." | 4.12 | Serum Uric Acid Levels and Their Changes and Risk of Stroke: A 7-Year Prospective Cohort Study in Northwest China. ( Bai, Y; Cheng, Z; Liu, Y; Luo, Y; Lv, K; Miao, Q; Wang, M; Yin, C; Zhang, D; Zheng, S, 2022) |
| "The role of serum uric acid (SUA) in stroke remains controversial and analyses of changes in SUA and stroke are limited." | 4.12 | Effect of changes in serum uric acid on the risk of stroke and its subtypes. ( Chen, S; Luo, Y; Mo, D; Tian, X; Wang, A; Wang, Y; Wu, S; Zhang, L; Zuo, Y, 2022) |
| "Previous studies have found that uric acid (UA) plays a neuroprotective role in ischemic stroke patients." | 4.12 | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke. ( Li, X; Ma, A; Pan, X; Wei, J; Yin, R, 2022) |
| " Whereas Serum Uric acid acts as a marker of tissue infarction; indicating poor prognosis of ischemic stroke." | 4.12 | A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke. ( Bc, PK; Somannavar, VG, 2022) |
| "Higher serum levels of homocysteine, CRP, and Pro-BNP are associated with a higher risk of acute ischemic stroke." | 4.12 | Role of Serum Homocysteine, C-Reactive Protein (CRP), Uric Acid & Pro-Brain Natriuretic Peptide (Pro-BNP) in Predicting the Functional Outcome in Patients with Ischemic Stroke- A Prospective Observational Study from North India. ( Atam, V; Chauhan, H; Reddy, DH; Sawlani, KK, 2022) |
| "The role of uric acid as a risk factor for cerebrovascular disease, particularly acute ischemic stroke, is controversial and there is little information about this in our setting." | 4.12 | Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh. ( Hossain, MS; Jasmine, T; Kamrul-Hasan, AB; Rahman, MM; Saha, PK; Sarker, MA, 2022) |
| "The final model included seven independent predictors: gender, age, baseline National Institute of Health Stroke Scale (NIHSS), hypertension, diabetes mellitus, white blood cell and serum uric acid." | 4.02 | Prognostic nomogram for patients with minor stroke and transient ischaemic attack. ( Feng, H; Lai, Y; Lei, Z; Li, C; Li, S; Ren, L; Zhou, Y, 2021) |
| "BACKGROUND Serum uric acid (UA) is involved in the development of hypertension." | 4.02 | U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study. ( Chen, K; Han, P; You, H; Yue, C; Zhao, X, 2021) |
| "Uric acid has long been considered responsible for a single specific disease, namely gout." | 4.02 | The URRAH study. ( Carubbi, F; Del Pinto, R; Ferri, C; Pontremoli, R; Russo, E; Viazzi, F, 2021) |
| "Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT)." | 4.02 | Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke. ( Chen, S; Cheng, Q; Dai, Y; Fan, K; He, J; Hu, J; Huang, G; Huang, Q; Liu, Y; Ren, W; Wang, L; Wu, C; Xu, M; Xu, R; Xue, L; Yan, F; Zhang, W; Zhu, Z, 2021) |
| "Recent studies on uric acid as a biomarker for the prognosis of acute stroke have found conflicting results." | 4.02 | Hyperuricaemia as a prognostic factor for acute ischaemic stroke. ( Cabrera Naranjo, FH; Fabre Pi, O; González Hernández, A; Saavedra Santana, P; Sosa-Henríquez, M, 2021) |
| "Uric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models." | 3.96 | Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke. ( Cheng, Y; Liu, J; Liu, M; Song, Q; Wang, Y; Wei, C, 2020) |
| "The role of serum uric acid as a predictor of stroke among the general Japanese population remains controversial." | 3.96 | Serum uric acid and risk of stroke and its types: the Circulatory Risk in Communities Study (CIRCS). ( Cui, R; Hayama-Terada, M; Imano, H; Iso, H; Kitamura, A; Kiyama, M; Li, J; Muraki, I; Ohira, T; Okada, T; Sankai, T; Tanigawa, T; Umesawa, M; Yamagishi, K, 2020) |
| "According to the results of this study, uric acid medians in patients with stroke and controls were 4." | 3.96 | Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke. ( Ahmadi, Z; Amirabadizadeh, A; Mousavi-Mirzaei, SM; Nakhaee, S; Talebi, A, 2020) |
| " Previous studies have shown that high serum uric acid (SUA) levels are an independent risk factor for hypertension, cardiovascular disease (CVD), and ischemic stroke." | 3.96 | Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis. ( Bai, CX; Chen, JZ; Ge, J; Hui, RT; Li, H; Liu, TL; Song, L; Song, WH; Sun, YY; Wen, HY; Xiao, N; Xu, HC; Zhang, YH, 2020) |
| "Increased level of serum uric acid (SUA) is often considered a risk factor for ischemic stroke." | 3.96 | Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh. ( Al Mamun, MA; Barman, N; Haque, MA; Khalil, MI; Salwa, M; Sultana, S, 2020) |
| "The role of serum uric acid in ischemic stroke is controversial." | 3.91 | Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles Pérez-Monteoliva, NR, 2019) |
| "This study investigated the association between serum uric acid (sUA) and stroke risk in men with hypertriglyceridemia." | 3.91 | Is serum uric acid a predictive factor for stroke in men with hypertriglyceridemia? ( Hsu, CY; Lai, YJ, 2019) |
| "Uric acid has gained considerable attention as a potential neuroprotective agent in stroke during the last decades, however, its role in the pathophysiology of ischemic stroke remains poorly understood." | 3.91 | Relationship between infarct size and serum uric acid levels during the acute phase of stroke. ( Bustamante, G; Cavada, G; Cortés-Fuentes, IA; Fernández-Gajardo, R; Feuerhake, W; Guerrero, R; Gutiérrez, R; Lozano, P; Matamala, JM; Pasten, JA; Reyes, P; Rodrigo, R; Sotomayor, CG; Vargas, G, 2019) |
| "This was a hospital-based prospective cohort study that included patients with ischemic stroke with baseline uric acid levels and 3-month post-stroke follow-up data." | 3.88 | The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans. ( Ayeah, CM; Ba, H; Hentchoya, R; Luma, HN; Mapoure, YN, 2018) |
| "The relationship between serum uric acid (SUA) levels and stroke is controversial." | 3.88 | Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function. ( Arévalo-Lorido, JC; Carretero-Gómez, J; Robles, NR, 2018) |
| "Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke." | 3.88 | High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke. ( Lai, R; Li, JX; Sheng, WL; Sun, XS; Wang, YF, 2018) |
| "Uric acid (UA), an antioxidant with neuroprotective effects, favorably affects stroke outcome." | 3.88 | Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone. ( Ando, Y; Inatomi, Y; Naganuma, M; Nakajima, M; Yonehara, T, 2018) |
| "Preclinical and clinical studies support a promising, albeit not definitive, neuroprotective effect of emergent uric acid (UA) administration in ischemic stroke." | 3.88 | Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats. ( Aliena-Valero, A; Burguete, MC; Castelló-Ruiz, M; Chamorro, Á; Hervás, D; Jover-Mengual, T; Leira, EC; López-Morales, MA; Salom, JB; Torregrosa, G, 2018) |
| "Uric acid is a molecule that is known to act as a natural antioxidant in acute oxidative stress conditions such as acute ischemic stroke (AIS)." | 3.88 | Can high uric acid levels be an independent risk factor for acute ischemic stroke due to large-artery atherosclerosis? ( Acar, AB; Acar, T; Gül, SS; Güzey Aras, Y, 2018) |
| "Our aim was to investigate the association between serum uric acid (SUA) levels and the risk of first stroke in a Chinese population of hypertensive patients." | 3.85 | Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort. ( Cai, Y; Dong, Q; Fu, J; He, M; Huo, Y; Li, J; Qin, X; Shi, X; Tang, G; Wang, B; Wang, K; Wang, L; Xu, X; Yang, J; Zhang, C; Zhang, Y; Zhao, G; Zhao, M, 2017) |
| "An association between serum uric acid and outcomes of ischemic stroke has been reported, but the results are controversial." | 3.85 | Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke. ( Fukuda, H; Kawase, S; Kowa, H; Kusumi, M; Nakashima, K; Nakayasu, H; Suto, Y, 2017) |
| "Elevated serum uric acid (UA) is known to be associated with stroke." | 3.85 | Sex-dependent effects of uric acid on cerebral microbleed: a cross-sectional study in the general population. ( Jeong, SM; Kim, S; Kim, SH; Kwon, HM; Lee, JE; Lim, JS; Nam, YS; Park, JH; Yoo, TG, 2017) |
| " This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population." | 3.85 | Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study. ( Asahi, K; Fujimoto, S; Hirayama, A; Ichikawa, K; Iseki, K; Kamei, K; Kasahara, M; Kondo, M; Konta, T; Kubota, I; Moriyama, T; Narita, I; Shibagaki, Y; Tsuruya, K; Watanabe, T; Yamagata, K, 2017) |
| "Conflicting results on the correlation between hyperuricemia and the prognosis of stroke had been reported and the close association between serum uric acid (SUA) and abnormal glycomatabolism might further complicate the assessment of the correlation." | 3.85 | Lower serum uric acid level strongly predict short-term poor functional outcome in acute stroke with normoglycaemia: a cohort study in China. ( Jun, WY; Pan, Y; Wang, C; Wu, S; Zhang, N, 2017) |
| "The importance and function of serum uric acid (UA) levels in patients with cardiovascular disease or stroke are unclear." | 3.83 | Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients. ( Cao, YJ; Huang, ZC; Liu, CF; Lu, TS; You, SJ; Zhang, X, 2016) |
| "In matched analysis, risk of ischaemic stroke increased by 15% for each 1 mg/dl increase in plasma uric acid [95% confidence interval (CI) 3%-28%], but was no longer significant after adjustment for cardiovascular risk factors, particularly history of hypertension." | 3.83 | Plasma uric acid concentrations and risk of ischaemic stroke in women. ( Choi, HK; Curhan, GC; Forman, JP; Jiménez, MC; Rexrode, KM, 2016) |
| " After adjustment of age, gender, education level, income, drink, history of myocardial infarction, history of stroke, serum uric acid and C reactive protein level, multiple Cox regression analysis showed that one health score point increase was related to 8% reduction of new onset atrial fibrillation(HR=0." | 3.83 | [Association between the cardiovascular health score and new-onset atrial fibrillation]. ( Ji, CP; Shi, JH; Wang, YZ; Wei, XM; Wu, SL; Xing, AJ; Zhu, CR, 2016) |
| "Although high uric acid levels have been reported to be a risk factor for cardiovascular disease and stroke, the relationship between serum uric acid (SUA) levels and cardioembolic stroke (CES) has not been fully elucidated." | 3.83 | Association of serum uric acid and cardioembolic stroke in patients with acute ischemic stroke. ( Jung, S; Kim, CK; Kim, TJ; Kim, Y; Lee, SH; Yang, XL, 2016) |
| "No evidence is currently provided on the involvement of uric acid (UA) and Cu/Zn Superoxide Dismutase (Cu/Zn SOD) in functional recovery of stroke patients after neurorehabilitation." | 3.81 | Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation. ( Ciancarelli, I; De Amicis, D; Di Massimo, C; Pistarini, C; Tozzi Ciancarelli, MG, 2015) |
| "Exogenous uric acid (UA) is a neuroprotective antioxidant that reinforces the benefits of intravenous recombinant tissue plasminogen activator thrombolysis in animal thromboembolic stroke." | 3.81 | Serum uric acid is neuroprotective in Chinese patients with acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator. ( Chen, M; Ge, QM; Liu, M; Liu, X; Pan, SM, 2015) |
| "Although a direct causal relationship between hyperuricaemia and stroke continues to be debated, strong associations between serum uric acid (SUA) and cerebrovascular disease exist." | 3.81 | Highly Prevalent Hyperuricaemia is Associated with Adverse Clinical Outcomes Among Ghanaian Stroke Patients: An Observational Prospective Study. ( Adamu, S; Akassi, J; Akpalu, A; Antwi, NK; Bedu-Addo, G; Obese, V; Sarfo, FS, 2015) |
| "To evaluate the relation of serum uric acid levels on admission with short-term clinical outcome and hemorrhagic transformation (HT) in patients with acute ischemic stroke treated with thrombolysis." | 3.81 | [Association study of serum uric acid levels with clinical outcome and hemorrhagic transformation in stroke patients with rt-PA intravenous thrombolysis]. ( Cao, Y; Jiang, C; Liu, C; Shi, J; Xu, J; You, S; Yu, X, 2015) |
| "The relationship between uric acid and stroke prognosis is ambiguous." | 3.80 | Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patients. ( Jia, Q; Liu, G; Liu, L; Pu, Y; Wang, C; Wang, Y; Wu, H; Zhao, X, 2014) |
| "Between 2009 and 2012, we conducted a study among 406 consecutive first-ever ischemic stroke patients to assess the relationship between uric acid and carotid artery." | 3.80 | Association of uric acid and carotid artery disease in patients with ischemic stroke. ( Kabaroglu, C; Karaman, B; Kumral, E; Orman, M, 2014) |
| "Over a 20-year period, patients on dapagliflozin were projected to experience relative reductions in the incidence of myocardial infarction (MI), stroke, CV death, and all-cause death of 13." | 3.80 | Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes. ( Alperin, P; Cohen, M; Dziuba, J; Goswami, D; Grossman, HL; Hardy, E; Iloeje, U; Perlstein, I; Racketa, J, 2014) |
| "To clarify the correlation of fatigue during the acute stage of stroke with serum uric acid (UA) and glucose levels, depression, and disability." | 3.80 | Correlation of fatigue during the acute stage of stroke with serum uric acid and glucose levels, depression, and disability. ( Huang, K; Shang, X; Teng, W; Wang, L; Wu, D, 2014) |
| "Current evidence shows that uric acid is a potent antioxidant whose serum concentration increases rapidly after acute ischemic stroke (AIS)." | 3.79 | Serum uric acid and outcome after acute ischemic stroke: PREMIER study. ( Arauz, A; Barinagarrementeria, F; Cantú-Brito, C; Chiquete, E; León-Jiménez, C; Murillo-Bonilla, LM; Ochoa-Guzmán, A; Orozco-Valera, DR; Ramos-Moreno, A; Ruiz-Sandoval, JL; Villarreal-Careaga, J, 2013) |
| "Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke." | 3.79 | Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke. ( Kim, BJ; Kim, CK; Lee, SH; Ryu, WS, 2013) |
| "These were post hoc analyses of datasets from the Aspirin Myocardial Infarction Study, a 1:1 randomized, double-blind clinical trial, conducted from 1975 to 1979, that examined mortality rates following daily aspirin administration over three years in individuals with documented MI." | 3.78 | Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction. ( Dabbous, O; Hariri, A; Krishnan, E; Lingala, B; Pandya, BJ, 2012) |
| "The prognostic value of serum uric acid (UA) in acute ischemic stroke is controversial." | 3.78 | Lack of association between serum uric acid levels and outcome in acute ischemic stroke. ( de Keyser, J; Koch, M; Kremer, B; Luijckx, GJ; Miedema, I; Uyttenboogaart, M, 2012) |
| "To investigate the association between serum uric acid (SUA) and early clinical outcome among patients with acute stroke." | 3.78 | [Association between serum uric acid and short-term clinical outcome among patients with acute stroke]. ( Peng, Y; Xu, Y; Zhang, JT; Zhang, XL; Zhang, YH, 2012) |
| "Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population." | 3.77 | Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients. ( Chen, Y; Ding, X; Fang, Y; Liu, Z; Shen, B; Teng, J; Wang, Y; Xu, S; Zhong, Y; Zou, J, 2011) |
| "There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management." | 3.77 | Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. ( Bleske, BE; Dorsch, MP; Erickson, SR; Gillespie, BW; Weder, AB, 2011) |
| "We developed a point system to estimate chronic kidney disease risk at 4 years using the following variables: age (8 points), body mass index (2 points), diastolic blood pressure (2 points), and history of type 2 diabetes (1 point) and stroke (4 points) for the clinical model, with the addition of uric acid (2 points), postprandial glucose (1 point), hemoglobin A1c (1 point), and proteinuria 100 mg/dL or greater (6 points) for the biochemical model." | 3.76 | A prediction model for the risk of incident chronic kidney disease. ( Chen, MF; Chien, KL; Hsu, HC; Lee, BC; Lee, YT; Lin, HJ, 2010) |
| " Mortality from all causes, total cardiovascular disease (CVD), ischemic stroke, congestive heart failure, hypertensive disease, and coronary heart disease were compared according to increasing serum uric acid levels." | 3.75 | Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. ( Chen, HJ; Chen, JH; Chuang, SY; Pan, WH; Yeh, WT, 2009) |
| "Few studies have simultaneously analysed the influence of elevated serum uric acid (UA) on acute myocardial infarction (AMI), ischaemic and haemorrhagic stroke (IS, HS) and congestive heart failure (CHF) in large healthy populations." | 3.75 | Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). ( Aastveit, AH; Hammar, N; Holme, I; Jungner, I; Walldius, G, 2009) |
| "Bilirubin (Bil) and uric acid (UA) are the endogenous antioxidant compounds possibly involved in the pathogenesis of ischemic stroke (IS)." | 3.75 | Serum bilirubin and uric acid levels as the bad prognostic factors in the ischemic stroke. ( Bartosik-Psujek, H; Bielewicz, J; Kurzepa, J; Stelmasiak, Z, 2009) |
| "The prognostic significance of uric acid (UA) levels in acute stroke is unclear, so the objective of this study was to determine the association between levels of serum UA (SUA) and mortality in acute stroke." | 3.74 | Serum uric acid as an independent predictor of early death after acute stroke. ( Athyros, VG; Gossios, T; Kakafika, A; Karagiannis, A; Krikis, N; Mikhailidis, DP; Moschou, I; Savvatianos, S; Sileli, M; Tziomalos, K; Xochellis, M, 2007) |
| "The role of serum uric acid (SUA) as an independent risk factor for cardiovascular disease (CVD) remains controversial, and little is known about its prognostic importance for mortality from congestive heart failure (CHF) and stroke." | 3.74 | Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83,683 Austrian men. ( Brant, L; Concin, H; Diem, G; Kelleher, C; Klenk, J; Pfeiffer, K; Ruttmann, E; Strasak, A; Ulmer, H, 2008) |
| "Since serum uric acid (UA) is strongly associated with cardiovascular risk factors, it has been debated whether serum UA is a stroke risk factor or whether UA may be simply "marking" subjects with other, causal risk factors." | 3.73 | Serum uric acid and risk of ischemic stroke: the ARIC Study. ( Folsom, AR; Hozawa, A; Ibrahim, H; Nieto, FJ; Rosamond, WD; Shahar, E, 2006) |
| "The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke." | 3.73 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. ( Bos, MJ; Breteler, MM; Hofman, A; Koudstaal, PJ; Witteman, JC, 2006) |
| "Uric acid is the end product of purine metabolism and a powerful water-soluble antioxidant and radical scavenger in humans whose generation is increased in situations of oxidative stress, such as brain ischemia." | 3.72 | Uric acid administration for neuroprotection in patients with acute brain ischemia. ( Chamorro, A; Deulofeu, R; Muner, DS; Planas, AM, 2004) |
| "There was some evidence of reduction in TAC, despite increased uric acid concentrations, and deterioration in serum vitamin C levels in ischaemic stroke patients compared with controls." | 3.71 | Antioxidant capacity after acute ischaemic stroke. ( Gariballa, SE; Hutchin, TP; Sinclair, AJ, 2002) |
| "Male type 2 diabetic patients with stroke had significantly higher mean levels of serum uric acid than simple diabetic patients, but such patients of both genders all had lower HDL levels." | 3.71 | [Serum uric acid in type 2 diabetic patients complicated by stroke]. ( Gao, F; Guan, MP; Li, CZ; Liu, SQ; Shen, J; Xue, YM; Zhou, L, 2002) |
| "We sought to assess in 881 consecutive patients with acute ischemic stroke the clinical relevance in regard to functional outcome of the natural antioxidant uric acid measured at hospital admission." | 3.71 | Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. ( Aponte, JH; Cervera, A; Chamorro, A; Deulofeu, R; Obach, V; Revilla, M, 2002) |
| " In 273 Type 2 diabetics, serum uric acid was analysed against basic demographic data (age, sex, smoking and alcohol habits, body mass index, number of years since the diagnosis of diabetes), present medications, control of diabetic state (attending physician's estimation of the patient's diet compliance, fasting serum sugar, HbA1c), and complications (serum creatinine, total cholesterol, triglyceride, urine proteinuria, retinopathy, last blood pressure readings, history of hypertension, coronary heart disease, stroke)." | 3.70 | Hyperuricaemia in Type 2 diabetes mellitus. ( Chan, CS; Lui, CS; Wun, YT, 1999) |
| "To investigate the risk factors for acute ischemic stroke (AIS) in patients with type 2 diabetes mellitus (T2DM) patients." | 3.30 | Risk factors for acute ischemic stroke in patients with type 2 diabetes mellitus. ( Li, X; Liu, J; Qu, J, 2023) |
| "Uric acid is an endogenous antioxidant making it a drug candidate to improve stroke outcomes." | 2.84 | Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy. ( Amaro, S; Arenillas, JF; Blasco, J; Cánovas, D; Castellanos, M; Chamorro, Á; Gomis, M; Leira, EC; Macho, J; Marti-Fabregas, J; Muñoz, R; Planas, AM; Román, LS; Urra, X, 2017) |
| "Cardiac death was the primary end-point." | 2.70 | Urate predicts subsequent cardiac death in stroke survivors. ( Crombie, I; Fraser, HW; MacWalter, RS; Ogston, SA; Struthers, AD; Wong, KY, 2002) |
| "Accumulating evidence suggests that hemiparesis exerts a protective effect against gout via the down-regulation of mechanical and neural modulators of inflammation in neurologically impaired extremities." | 2.46 | Polyarticular gout attacks following cerebrovascular accidents: is hemiparesis in fact protective? 2 cases and a review of the literature. ( Furer, V; Hsiao, SJ; Samuels, J; Vaynrub, M, 2010) |
| "Calcium antagonists are used in the treatment of hypertension and angina." | 2.44 | The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension. ( Coca, A; Sierra, C, 2008) |
| "Apparent treatment-resistant hypertension (aTRH) was defined as a SBP ≥ 140 mmHg or DBP ≥ 90 mmHg with concurrent use of three classes of antihypertensive medications, or taking four or more classes of antihypertensive medication regardless of BP level." | 1.91 | Hypertension severity, apparent treatment resistant hypertension and hyperuricemia in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. ( Bridges, SL; Chaudary, N; Colantonio, LD; Cushman, M; Howard, G; Irvin, MR; Limdi, N; Merriman, TR; Muntner, P; Reynolds, RJ; Saag, K; Tanner, RM, 2023) |
| "Uric acid (UA) has both antioxidative and pro-oxidative properties." | 1.72 | U-Shaped Association Between Serum Uric Acid and Hemorrhagic Transformation After Intravenous Thrombolysis. ( Chen, H; Cheng, Z; Fu, Y; Han, Z; Xia, L; Xu, T; Zhan, Z; Zhang, WY, 2022) |
| "Of those, 80% had generalized seizures, 13." | 1.72 | Stroke Characteristics as Predictors of New-onset Seizure in Patients with Acute Ischemic Stroke. ( Ajmal, M; Bhat, NK; Dhar, M; Jose, A; Mohan, L; Saxena, Y, 2022) |
| "Uric acid was the leading metabolite in univariate analysis of both hyperglycemia (OR 19." | 1.62 | Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke. ( Acharjee, A; Ament, Z; Bevers, MB; Kimberly, WT; Wolcott, Z, 2021) |
| "Uric acid (UA) is an important endogenous free radical scavenger that has been found to have a neuroprotective effect." | 1.62 | Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy. ( Cui, T; Hao, Z; Wang, A; Wang, C; Wang, L; Wu, B; Yuan, Y; Zhu, Q, 2021) |
| "In particular, apparent treatment-resistant hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg on 3 antihypertensive medications or use of ≥4 antihypertensive medications) and the count of antihypertensive medication classes significantly reduced the effect of hyperuricemia on ischemic stroke." | 1.56 | Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study. ( Bridges, SL; Chaudhary, NS; Colantonio, LD; Curtis, JR; Cushman, M; Flaherty, ML; Gaffo, A; Howard, G; Irvin, MR; Judd, S; Levitan, EB; Limdi, NA; Rahn, EJ; Reynolds, RJ; Saag, KG; Singh, JA, 2020) |
| " The effect of uricosuric agents on the decrease in hospitalized stroke risk indicated a dose-response relationship." | 1.56 | Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout. ( Hsu, CC; Hwu, CM; Li, HL; Wei, JC; Yen, FS, 2020) |
| "Hyperuricemia was defined as the serum uric acid level of more than 6 mg/dl." | 1.56 | Association between Hyperuricemia and Ischemic Stroke: A Case-Control Study. ( Fatima, T; Iftikhar, S; Qureshi, IH, 2020) |
| "Uric acid has neuroprotective properties in experimental and clinical studies of neurodegenerative disease." | 1.48 | Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke. ( Liu, H; Reynolds, GP; Wang, W; Wei, X, 2018) |
| "Acute ischemic stroke is caused by stenosis of artery supplying to brain." | 1.48 | Serum Calcium is Related to the Degree of Artery Stenosis in Acute Ischemic Stroke. ( Gong, L; Liu, W; Liu, X; Wu, J; Xie, J; Zhao, Y, 2018) |
| "Stroke is a growing disease and it is the second common cause of death in the world after coronary heart disease especially in the elderly." | 1.48 | Serum Uric Acid Levels and Serum Lipid Levels in Patients with Ischemic Cerebrovascular Accident. ( Arora, T; Bidri, RC; Mantur, PG; Mulimani, MS, 2018) |
| "Uric acid (UA) plays an important role in the oxidant stress that causes inflammation." | 1.43 | Association of uric acid with traditional inflammatory factors in stroke. ( Xiong, G; Zhang, J; Zhu, A; Zou, T, 2016) |
| "Uric acid level was elevated in ischemic stroke than haemorrhagic stroke patients (p<0." | 1.43 | Serum Uric Acid Level among Acute Stroke Patients. ( Bhuiyan, AS; Chowdhury, M; Das, BR; Das, SN; Haque, MF; Jahan, MK; Mohsin, M; Rahman, MM; Saha, PL; Shikha, SS, 2016) |
| "Uric acid (UA) has been known to be a neuroprotective antioxidant because of its free radical scavenger activity." | 1.40 | Effects of uric acid levels on outcome in severe ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator. ( Chang, DI; Heo, SH; Kim, HY; Kim, JH; Kim, YS; Koh, SH; Lee, D; Lee, JS; Lee, SH, 2014) |
| "Stroke is an enormous public health problem with an imperative need for more effective therapy." | 1.37 | Translational stroke research of the combination of thrombolysis and antioxidant therapy. ( Amaro, S; Chamorro, Á, 2011) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 1.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "Hypertension is an independent risk factor for peripheral arterial disease." | 1.34 | Prevalence of and risk factors for peripheral arterial disease in the patients with hypertension among Han Chinese. ( Hui, R; Sun, K; Wu, H; Yang, X; Zhang, H; Zhang, W, 2007) |
| "Stroke is a leading cause of mortality and subsequent serious long-term physical and mental disability among survivors." | 1.33 | Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals. ( Bairaktari, ET; Elisaf, MS; Goudevenos, J; Liberopoulos, E; Milionis, HJ; Seferiadis, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.51) | 18.7374 |
| 1990's | 2 (1.01) | 18.2507 |
| 2000's | 47 (23.74) | 29.6817 |
| 2010's | 94 (47.47) | 24.3611 |
| 2020's | 54 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Tikhonoff, V | 1 |
| Casiglia, E | 1 |
| Spinella, P | 1 |
| Barbagallo, CM | 1 |
| Bombelli, M | 1 |
| Cicero, AFG | 1 |
| Cirillo, M | 1 |
| Cirillo, P | 1 |
| Desideri, G | 1 |
| D'elia, L | 1 |
| Ferri, C | 2 |
| Galletti, F | 1 |
| Gesualdo, L | 1 |
| Giannattasio, C | 1 |
| Iaccarino, G | 1 |
| Mallamaci, F | 1 |
| Maloberti, A | 1 |
| Masi, S | 1 |
| Mazza, A | 1 |
| Muiesan, ML | 1 |
| Nazzaro, P | 1 |
| Palatini, P | 1 |
| Parati, G | 1 |
| Pontremoli, R | 2 |
| Quarti-Trevano, F | 1 |
| Rattazzi, M | 1 |
| Rivasi, G | 1 |
| Salvetti, M | 1 |
| Tocci, G | 1 |
| Ungar, A | 1 |
| Verdecchia, P | 1 |
| Viazzi, F | 2 |
| Virdis, A | 1 |
| Volpe, M | 1 |
| Grassi, G | 1 |
| Borghi, C | 1 |
| Zheng, S | 1 |
| Luo, Y | 4 |
| Miao, Q | 1 |
| Cheng, Z | 2 |
| Liu, Y | 4 |
| Lv, K | 1 |
| Zhang, D | 2 |
| Yin, C | 1 |
| Wang, M | 2 |
| Bai, Y | 1 |
| Tian, Y | 1 |
| Xie, Q | 1 |
| You, J | 1 |
| Yang, S | 1 |
| Zhao, H | 1 |
| Song, Y | 2 |
| Wang, A | 6 |
| Tian, X | 4 |
| Zuo, Y | 1 |
| Chen, S | 5 |
| Mo, D | 1 |
| Zhang, L | 3 |
| Wu, S | 4 |
| Wang, Y | 11 |
| Wei, J | 2 |
| Yin, R | 1 |
| Li, X | 2 |
| Pan, X | 1 |
| Ma, A | 1 |
| Liu, L | 4 |
| Zhang, X | 8 |
| Peng, L | 1 |
| Ma, N | 1 |
| Yang, T | 1 |
| Nie, C | 1 |
| Xu, Z | 1 |
| Yang, J | 3 |
| Tang, X | 1 |
| Zheng, L | 1 |
| Zhang, T | 1 |
| Hong, F | 1 |
| Bc, PK | 1 |
| Somannavar, VG | 1 |
| Chauhan, H | 1 |
| Atam, V | 1 |
| Sawlani, KK | 1 |
| Reddy, DH | 1 |
| Yan, X | 1 |
| Ren, Z | 1 |
| Wen, Q | 1 |
| Jin, X | 1 |
| Zhang, W | 4 |
| Rahman, MM | 3 |
| Kamrul-Hasan, AB | 1 |
| Jasmine, T | 1 |
| Hossain, MS | 1 |
| Saha, PK | 1 |
| Sarker, MA | 1 |
| Zhan, Z | 1 |
| Fu, Y | 1 |
| Zhang, WY | 1 |
| Xia, L | 1 |
| Xu, T | 5 |
| Chen, H | 1 |
| Han, Z | 1 |
| Gong, Y | 1 |
| Zhou, Y | 2 |
| Qin, X | 3 |
| Meng, X | 2 |
| Chen, P | 1 |
| Mackenzie, IS | 1 |
| Hawkey, CJ | 1 |
| Ford, I | 1 |
| Greenlaw, N | 1 |
| Pigazzani, F | 1 |
| Rogers, A | 1 |
| Struthers, AD | 4 |
| Begg, AG | 1 |
| Wei, L | 1 |
| Avery, AJ | 1 |
| Taggar, JS | 1 |
| Walker, A | 1 |
| Duce, SL | 1 |
| Barr, RJ | 1 |
| Dumbleton, JS | 1 |
| Rooke, ED | 1 |
| Townend, JN | 1 |
| Ritchie, LD | 1 |
| MacDonald, TM | 1 |
| Li, YM | 1 |
| Yu, Q | 1 |
| Huang, L | 1 |
| Fu, J | 2 |
| Feng, RJ | 1 |
| Wang, P | 2 |
| Zhang, Y | 9 |
| Xu, Q | 2 |
| Tanner, RM | 1 |
| Chaudary, N | 1 |
| Colantonio, LD | 2 |
| Merriman, TR | 1 |
| Reynolds, RJ | 2 |
| Bridges, SL | 2 |
| Cushman, M | 2 |
| Saag, K | 1 |
| Limdi, N | 1 |
| Muntner, P | 1 |
| Howard, G | 2 |
| Irvin, MR | 2 |
| Zhang, C | 2 |
| Meng, P | 1 |
| Gao, H | 1 |
| Bai, B | 1 |
| Li, D | 1 |
| Li, M | 2 |
| Wang, H | 2 |
| Gao, Y | 1 |
| Gao, B | 1 |
| Bao, Y | 1 |
| Meng, M | 1 |
| Yu, L | 1 |
| Lu, Y | 1 |
| Sa, R | 1 |
| Liang, X | 1 |
| Shi, J | 2 |
| Khaled, Y | 1 |
| Abdelhamid, AA | 1 |
| Al-Mazroey, H | 1 |
| Almannai, AK | 1 |
| Fetais, S | 1 |
| Al-Srami, AS | 1 |
| Ahmed, S | 1 |
| Al-Hajri, N | 1 |
| Mustafa, A | 1 |
| Chivese, T | 1 |
| Djouhri, L | 1 |
| Jose, A | 1 |
| Dhar, M | 1 |
| Ajmal, M | 1 |
| Mohan, L | 1 |
| Saxena, Y | 1 |
| Bhat, NK | 1 |
| Nakamura, K | 1 |
| Ueki, K | 1 |
| Matsuo, R | 1 |
| Kiyohara, T | 1 |
| Irie, F | 1 |
| Wakisaka, Y | 1 |
| Ago, T | 1 |
| Kamouchi, M | 1 |
| Kitazono, T | 1 |
| Dai, Y | 2 |
| Jiang, Y | 2 |
| Qiu, X | 1 |
| Gu, H | 1 |
| Li, Z | 1 |
| McCormick, N | 1 |
| Yokose, C | 1 |
| Lu, N | 1 |
| Wexler, DJ | 1 |
| Aviña-Zubieta, JA | 1 |
| De Vera, MA | 1 |
| Choi, HK | 3 |
| Geng, D | 2 |
| Wu, B | 2 |
| Lin, Y | 3 |
| Chen, J | 2 |
| Tang, W | 1 |
| He, J | 5 |
| Zang, Y | 1 |
| Zheng, H | 1 |
| Liu, S | 1 |
| Wang, S | 1 |
| Shi, Y | 2 |
| Leira, EC | 3 |
| Planas, AM | 13 |
| Chauhan, AK | 1 |
| Chamorro, A | 21 |
| Zhang, S | 2 |
| Liu, J | 2 |
| Qu, J | 1 |
| He, W | 1 |
| Qiu, H | 1 |
| Zhu, J | 1 |
| Feng, W | 1 |
| Shu, M | 1 |
| Shao, Y | 1 |
| Shao, H | 1 |
| Sawhney, MS | 1 |
| Shi, L | 1 |
| Song, Q | 1 |
| Cheng, Y | 1 |
| Wei, C | 1 |
| Liu, M | 3 |
| Chaudhary, NS | 1 |
| Saag, KG | 1 |
| Rahn, EJ | 1 |
| Curtis, JR | 1 |
| Gaffo, A | 1 |
| Limdi, NA | 1 |
| Levitan, EB | 1 |
| Singh, JA | 1 |
| Flaherty, ML | 1 |
| Judd, S | 1 |
| Ae, R | 1 |
| Kanbay, M | 2 |
| Kuwabara, M | 1 |
| Li, J | 3 |
| Muraki, I | 1 |
| Imano, H | 1 |
| Cui, R | 1 |
| Yamagishi, K | 1 |
| Umesawa, M | 1 |
| Hayama-Terada, M | 1 |
| Ohira, T | 1 |
| Kiyama, M | 1 |
| Okada, T | 1 |
| Sankai, T | 1 |
| Tanigawa, T | 1 |
| Kitamura, A | 1 |
| Iso, H | 1 |
| Mazidi, M | 1 |
| Katsiki, N | 1 |
| Mikhailidis, DP | 4 |
| Banach, M | 1 |
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| Longo-Mbenza, B | 1 |
| Luila, EL | 1 |
| Mbete, P | 1 |
| Vita, EK | 1 |
| Wun, YT | 1 |
| Chan, CS | 1 |
| Lui, CS | 1 |
| Franse, LV | 1 |
| Pahor, M | 1 |
| Di Bari, M | 1 |
| Shorr, RI | 1 |
| Wan, JY | 1 |
| Somes, GW | 1 |
| Applegate, WB | 1 |
| Bregnocchi, M | 1 |
| Pezzuto, S | 1 |
| di Iorio, A | 1 |
| Revilla, M | 1 |
| Aponte, JH | 1 |
| Yusuf, S | 1 |
| Bosch, J | 1 |
| Wong, KY | 1 |
| MacWalter, RS | 1 |
| Fraser, HW | 1 |
| Crombie, I | 1 |
| Ogston, SA | 1 |
| Seghieri, G | 1 |
| Moruzzo, D | 1 |
| Fascetti, S | 1 |
| Bambini, C | 1 |
| Anichini, R | 1 |
| De Bellis, A | 1 |
| Alviggi, L | 1 |
| Franconi, F | 1 |
| Torbus-Lisiecka, B | 1 |
| Bukowska, H | 1 |
| Jastrzebska, M | 1 |
| Chelstowski, K | 1 |
| Honczarenko, K | 1 |
| Naruszewicz, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset[NCT00860366] | Phase 2/Phase 3 | 421 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Serum Uric Acid Levels and Initial Presentation of Cardiovascular Diseases: a CALIBER Study[NCT03425305] | 180,000 participants (Actual) | Observational | 1998-01-31 | Active, not recruiting | |||
| Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia[NCT04744987] | 122 participants (Actual) | Observational | 2019-07-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 reviews available for uric acid and Apoplexy
| Article | Year |
|---|---|
Uric Acid and Cognitive Impairment in Patients with Acute Ischemic Stroke: A Meta-Analysis.
Topics: Cognitive Dysfunction; Humans; Ischemic Stroke; Prospective Studies; Stroke; Uric Acid | 2022 |
Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis.
Topics: Brain Ischemia; Case-Control Studies; Humans; Ischemic Stroke; Risk Factors; Stroke; Uric Acid | 2023 |
Uric Acid: A Translational Journey in Cerebroprotection That Spanned Preclinical and Human Data.
Topics: Animals; Brain Ischemia; Female; Humans; Ischemic Stroke; Male; Mice; Microcirculation; Multicenter | 2023 |
Serum uric acid as a risk factor of all-cause mortality and cardiovascular events among type 2 diabetes population: Meta-analysis of correlational evidence.
Topics: Aged; Cardiovascular Diseases; Cause of Death; Diabetes Complications; Diabetes Mellitus, Type 2; Hu | 2019 |
Associations of serum uric acid with total and cause-specific mortality: Findings from individuals and pooling prospective studies.
Topics: Age Distribution; Alcohol Drinking; Cause of Death; Coronary Disease; Diet; Exercise; Female; Humans | 2020 |
Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis.
Topics: Cardiovascular Diseases; Coronary Artery Disease; Humans; Hypertension; Prognosis; Risk Factors; Str | 2021 |
Sex-Specific Relationship Between Serum Uric Acid and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies.
Topics: Female; Humans; Hyperuricemia; Male; Prospective Studies; Risk Factors; Sex Factors; Stroke; Uric Ac | 2017 |
Serum Uric Acid Level and Outcome of Patients With Ischemic Stroke: A Systematic Review and Meta-Analysis.
Topics: Biomarkers; Brain Ischemia; Fibrinolytic Agents; Humans; Prognosis; Stroke; Thrombolytic Therapy; Ti | 2019 |
Dose-response relationship of serum uric acid levels with risk of stroke mortality.
Topics: Female; Humans; Male; Prospective Studies; Risk Assessment; Stroke; Uric Acid | 2014 |
Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke.
Topics: Brain Ischemia; Humans; Publication Bias; Stroke; Treatment Outcome; Uric Acid | 2016 |
The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature.
Topics: Animals; Brain Ischemia; Fibrinolytic Agents; Humans; Neuroprotective Agents; PubMed; Stroke; Tissue | 2015 |
Administration of Uric Acid in the Emergency Treatment of Acute Ischemic Stroke.
Topics: Animals; Brain Ischemia; Emergency Treatment; Fibrinolytic Agents; Humans; Oxidative Stress; Stroke; | 2016 |
The role of uric acid in stroke: the issue remains unresolved.
Topics: Animals; Humans; Hyperuricemia; Risk Factors; Stroke; Uric Acid | 2008 |
The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension.
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Comorbidity; Cor | 2008 |
Hyperuricemia and risk of stroke: a systematic review and meta-analysis.
Topics: Adolescent; Adult; Aged; Female; Humans; Hyperuricemia; Incidence; Male; Middle Aged; Risk Factors; | 2009 |
Polyarticular gout attacks following cerebrovascular accidents: is hemiparesis in fact protective? 2 cases and a review of the literature.
Topics: Central Nervous System; Gout; Humans; Male; Middle Aged; Paresis; Rheumatic Diseases; Stroke; Thromb | 2010 |
Uric acid, hyperuricemia and vascular diseases.
Topics: Coronary Disease; Gout; Humans; Hypertension; Hyperuricemia; Inflammasomes; Inflammation; Metabolic | 2012 |
The role of serum uric acid in cardiovascular disease in type 2 diabetic and non-diabetic subjects: a narrative review.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Hypertension; Risk | 2011 |
Potential markers of oxidative stress in stroke.
Topics: Aldehydes; Animals; Antioxidants; Ascorbic Acid; Biomarkers; DNA Damage; Free Radicals; Humans; Lipi | 2005 |
The pleiotropic effects of angiotensin receptor blockers.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting En | 2006 |
Uric acid administration in patients with acute stroke: a novel approach to neuroprotection.
Topics: Animals; Humans; Neuroprotective Agents; Oxidative Stress; Stroke; Uric Acid | 2008 |
24 trials available for uric acid and Apoplexy
| Article | Year |
|---|---|
Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.
Topics: Aged; Allopurinol; Coronary Artery Disease; Female; Gout; Humans; Male; Myocardial Infarction; Myoca | 2022 |
Risk factors for acute ischemic stroke in patients with type 2 diabetes mellitus.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Biomarkers; C-Reactive Protein; Cholesterol, LDL; Di | 2023 |
Positive association of serum uric acid with new-onset diabetes in Chinese women with hypertension in a retrospective analysis of the China Stroke Primary Prevention Trial.
Topics: Adult; China; Diabetes Mellitus; Female; Humans; Hypertension; Male; Primary Prevention; Prospective | 2020 |
Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy.
Topics: Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Stroke; T | 2017 |
U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke.
Topics: Aged; Brain Ischemia; Disease-Free Survival; Female; Humans; Male; Middle Aged; Prospective Studies; | 2018 |
Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension.
Topics: Animals; Antioxidants; Biomarkers; Blood-Brain Barrier; Brain; Cell Line; Double-Blind Method; Endot | 2019 |
Relevance of Collaterals for the Success of Neuroprotective Therapies in Acute Ischemic Stroke: Insights from the Randomized URICO-ICTUS Trial.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Cerebrovascular Circulation; Collateral Circulation; Double | 2019 |
Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial.
Topics: Aged; Aged, 80 and over; Antioxidants; Brain; Double-Blind Method; Female; Humans; Male; Odds Ratio; | 2014 |
Uric acid improves glucose-driven oxidative stress in human ischemic stroke.
Topics: Aged; Aged, 80 and over; Antioxidants; Blood Glucose; Brain Ischemia; Double-Blind Method; Female; H | 2015 |
Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke.
Topics: Aged; Aged, 80 and over; Antioxidants; Brain Ischemia; Double-Blind Method; Female; Humans; Male; Mi | 2015 |
Uric Acid Therapy Prevents Early Ischemic Stroke Progression: A Tertiary Analysis of the URICO-ICTUS Trial (Efficacy Study of Combined Treatment With Uric Acid and r-tPA in Acute Ischemic Stroke).
Topics: Antioxidants; Brain Ischemia; Double-Blind Method; Drug Therapy, Combination; Fibrinolytic Agents; H | 2016 |
Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial.
Topics: Adult; Aged; Brain Ischemia; China; Female; Humans; Male; Middle Aged; Prognosis; Risk Factors; Sex | 2016 |
Serum urate predicts long-term risk of acute coronary events in women after a transient ischaemic attack and stroke.
Topics: Acute Disease; Aged; Aspirin; Biomarkers; Coronary Disease; Female; Humans; Ischemic Attack, Transie | 2008 |
Allopurinol treatment reduces arterial wave reflection in stroke survivors.
Topics: Aged; Allopurinol; Antioxidants; Arteries; Blood Pressure; Double-Blind Method; Elasticity; Enzyme I | 2008 |
Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke: a proof-of-concept study.
Topics: Aged; Antioxidants; Double-Blind Method; Female; Follow-Up Studies; Humans; Injections, Intravenous; | 2009 |
The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial.
Topics: Aged; Allopurinol; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Double-Blind Me | 2009 |
The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms.
Topics: Adult; Aged; Biomarkers; Brain Ischemia; Clinical Protocols; Double-Blind Method; Drug Therapy, Comb | 2010 |
Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke.
Topics: Aged; Antioxidants; Ascorbic Acid; Biomarkers; Brain Ischemia; C-Reactive Protein; Chemokine CCL2; C | 2004 |
Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study.
Topics: Ascorbic Acid; Aspirin; Carotenoids; Dinoprost; Humans; Kinetics; Lipid Peroxidation; Oxidative Stre | 2005 |
A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Double-Blind Method; Drug Therapy, Combination; Fibrinolyti | 2007 |
Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans?
Topics: Black People; Coronary Disease; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middl | 1999 |
Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP).
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Biomarkers; Cardiovascular Dis | 2000 |
Antioxidant profile and early outcome in stroke patients.
Topics: Aged; Analysis of Variance; Antioxidants; Ascorbic Acid; Brain Ischemia; Chromatography, High Pressu | 2000 |
Urate predicts subsequent cardiac death in stroke survivors.
Topics: Aged; Biomarkers; Death; Female; Follow-Up Studies; Humans; Male; Predictive Value of Tests; Regress | 2002 |
153 other studies available for uric acid and Apoplexy
| Article | Year |
|---|---|
Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study.
Topics: Humans; Hypertension; Prognosis; Risk Factors; Stroke; Uric Acid | 2022 |
Serum Uric Acid Levels and Their Changes and Risk of Stroke: A 7-Year Prospective Cohort Study in Northwest China.
Topics: China; Cohort Studies; Female; Humans; Hyperuricemia; Male; Prospective Studies; Risk Factors; Strok | 2022 |
Lower uric acid level may be associated with hemorrhagic transformation after intravenous thrombolysis.
Topics: Brain Ischemia; Humans; Ischemic Stroke; Retrospective Studies; Stroke; Thrombolytic Therapy; Uric A | 2022 |
Effect of changes in serum uric acid on the risk of stroke and its subtypes.
Topics: Adult; Humans; Hyperuricemia; Middle Aged; Myocardial Infarction; Prognosis; Risk Factors; Stroke; U | 2022 |
Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke.
Topics: Brain Ischemia; Female; Humans; Ischemic Stroke; Male; Prevalence; Retrospective Studies; Stroke; Ur | 2022 |
Hyperuricemia is Related to the Risk of Cardiovascular Diseases in Ethnic Chinese Elderly Women.
Topics: Adult; Aged; Cardiovascular Diseases; China; Cross-Sectional Studies; Ethnicity; Female; Humans; Hyp | 2022 |
A Study on the Role of Serum Calcium, Serum Albumin and Serum Uric Acid as Markers of Initial Neurological Severity and Short Term Outcome Indicators in Acute Ischemic Stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Calcium; Child, Preschool; Cross-Sectional Studies; Female; Humans | 2022 |
Role of Serum Homocysteine, C-Reactive Protein (CRP), Uric Acid & Pro-Brain Natriuretic Peptide (Pro-BNP) in Predicting the Functional Outcome in Patients with Ischemic Stroke- A Prospective Observational Study from North India.
Topics: Adult; Aged; Biomarkers; Brain Ischemia; C-Reactive Protein; Embolic Stroke; Female; Homocysteine; H | 2022 |
Relationship of Serum Uric Acid Level with Acute Ischemic Stroke: A Single-Center, Hospital-Based Study from Bangladesh.
Topics: Bangladesh; Brain Ischemia; Cholesterol; Cross-Sectional Studies; Hospitals; Humans; Hypertension; H | 2022 |
U-Shaped Association Between Serum Uric Acid and Hemorrhagic Transformation After Intravenous Thrombolysis.
Topics: Brain Ischemia; Fibrinolytic Agents; Humans; Intracranial Hemorrhages; Ischemic Stroke; Retrospectiv | 2022 |
Association between serum uric acid to serum creatinine ratio and poor functional outcomes in patients with acute ischemic stroke.
Topics: Creatinine; Humans; Ischemic Stroke; Prognosis; Stroke; Uric Acid | 2022 |
[Correlations Between Gut Microbiota Changes and Cognitive Function in Patients with Post-Stroke Cognitive Impairment in the Early Stage].
Topics: Bacteria; Bifidobacterium; Biomarkers; Clostridiales; Cognition; Cognitive Dysfunction; Cross-Sectio | 2022 |
Association of serum uric acid to lymphocyte ratio, a novel inflammatory biomarker, with risk of stroke: A prospective cohort study.
Topics: Biomarkers; Humans; Lymphocytes; Prospective Studies; Risk Factors; Stroke; Uric Acid | 2023 |
Hypertension severity, apparent treatment resistant hypertension and hyperuricemia in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Hyperuricemia; Male; R | 2023 |
The association between serum uric acid and cognitive performance in patients with ischemic stroke is modified by estimated glomerular filtration rate.
Topics: Aged; Cognition; Female; Glomerular Filtration Rate; Humans; Ischemic Stroke; Male; Retrospective St | 2023 |
Association of serum uric acid with risk of stroke in US adults: A cross-sectional study from NHANES 1999-2020.
Topics: Adult; Alcoholic Intoxication; Cross-Sectional Studies; Humans; Nutrition Surveys; Stroke; Uric Acid | 2023 |
Higher serum uric acid is associated with poorer cognitive performance in healthy middle-aged people: a cross-sectional study.
Topics: Adult; Aged; Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Male; Middle | 2023 |
Cumulative Serum Uric Acid Exposure and Its Time Course With the Risk of Incident Stroke.
Topics: China; Humans; Ischemic Stroke; Prospective Studies; Risk Factors; Stroke; Uric Acid | 2023 |
Stroke Characteristics as Predictors of New-onset Seizure in Patients with Acute Ischemic Stroke.
Topics: Anticonvulsants; Female; Humans; Ischemic Stroke; Male; Middle Aged; Seizures; Stroke; Uric Acid | 2022 |
Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study.
Topics: Female; Hospitalization; Hospitals; Humans; Ischemic Stroke; Male; Stroke; Uric Acid | 2023 |
Moderate elevation of serum uric acid levels improves short-term functional outcomes of ischemic stroke in patients with type 2 diabetes mellitus.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Ischemic Stroke; Male; Prognosis; Risk Factors; Str | 2023 |
Comparative Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations : A General Population Cohort Study.
Topics: Cohort Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucose; Gout; Hospit | 2023 |
High total bilirubin-to-uric acid ratio predicts poor sleep quality after acute ischemic stroke: a prospective nested case-control study.
Topics: Bilirubin; Biomarkers; Case-Control Studies; Female; Humans; Ischemic Stroke; Prospective Studies; S | 2023 |
Assessment and prognostic value of serum uric acid and neuron-specific enolase on the efficacy of intravenous thrombolytic therapy in cerebral infarction.
Topics: Brain Ischemia; Cerebral Infarction; Fibrinolytic Agents; Humans; Phosphopyruvate Hydratase; Prognos | 2023 |
Factors influencing TCM syndrome types of acute cerebral infarction: A binomial logistic regression analysis.
Topics: Brain Ischemia; Cerebral Infarction; Cholesterol; Homocysteine; Humans; Logistic Models; Medicine, C | 2023 |
The effect of uric acid on sleep quality after acute ischemic stroke.
Topics: Aged; Female; Humans; Male; Middle Aged; Prospective Studies; Sleep Wake Disorders; Stroke; Uric Aci | 2019 |
Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Strok | 2020 |
Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study.
Topics: Aged; Blood Pressure; Cohort Studies; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged | 2020 |
The causality between the serum uric acid level and stroke.
Topics: Brain Ischemia; Cardiovascular System; Humans; Stroke; Uric Acid | 2020 |
Serum uric acid and risk of stroke and its types: the Circulatory Risk in Communities Study (CIRCS).
Topics: Female; Hemorrhagic Stroke; Humans; Incidence; Ischemic Stroke; Male; Middle Aged; Risk; Sex Factors | 2020 |
Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Cross-Sectional Studies; Femal | 2020 |
The association between serum uric acid levels and ischemic stroke in essential hypertension patients.
Topics: Biomarkers; Brain Ischemia; China; Essential Hypertension; Female; Humans; Kaplan-Meier Estimate; Ma | 2020 |
Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis.
Topics: Animals; Cerebral Hemorrhage; Humans; Hypertension; Intracranial Hemorrhage, Hypertensive; MAP Kinas | 2020 |
Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout.
Topics: Adult; Aged; Allopurinol; Female; Gout; Gout Suppressants; Hospital Mortality; Hospitalization; Huma | 2020 |
Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh.
Topics: Aged; Bangladesh; Brain Ischemia; Case-Control Studies; Female; Humans; Logistic Models; Male; Middl | 2020 |
Association between Hyperuricemia and Ischemic Stroke: A Case-Control Study.
Topics: Brain Ischemia; Case-Control Studies; Humans; Hyperuricemia; Ischemic Stroke; Risk Factors; Stroke; | 2020 |
Prognostic nomogram for patients with minor stroke and transient ischaemic attack.
Topics: Adult; Aged; Brain Ischemia; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Nomogram | 2021 |
Elevated postoperative serum uric acid is associated with major adverse events following coronary artery bypass grafting.
Topics: Aged; Biomarkers; Coronary Artery Bypass; Coronary Artery Disease; Female; Hospital Mortality; Human | 2020 |
Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke.
Topics: Brain Ischemia; Gluconates; Humans; Hyperglycemia; Laboratories, Clinical; Stroke; Uric Acid | 2021 |
Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Humans; Ischemic Stroke; Male; Middle Aged; Prognos | 2021 |
Higher uric acid is associated with better discharge recovery and short-term outcome in stroke patients treated with thrombolysis.
Topics: Brain Ischemia; Humans; Patient Discharge; Prognosis; Retrospective Studies; Stroke; Thrombolytic Th | 2021 |
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study.
Topics: Cardiovascular Diseases; Cardiovascular System; Cause of Death; Cohort Studies; Female; Follow-Up St | 2021 |
The URRAH study.
Topics: Diabetes Mellitus, Type 2; Gout; Heart Failure; Humans; Hypertension; Retrospective Studies; Stroke; | 2021 |
Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Case-Control Studies; Dementia; Female; Glucocorticoi | 2021 |
Relation of Serum Uric Acid and Cardiovascular Events in Young Adults Aged 20-49 Years.
Topics: Adult; Atrial Fibrillation; Cardiovascular Diseases; Female; Heart Failure; Humans; Hyperuricemia; I | 2021 |
Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; China; Cross-Sectional Studies; Female; Health Status Dispariti | 2021 |
[The relationship between LDL-C and ischemic stroke in 2 470 patients with nonvalvular atrial fibrillation in Xinjiang region].
Topics: Aged; Atrial Fibrillation; Case-Control Studies; Cholesterol; Cholesterol, LDL; Female; Humans; Male | 2017 |
Relationship between serum uric acid and ischemic stroke in a large type 2 diabetes population in China: A cross-sectional study.
Topics: Age Factors; Aged; Biomarkers; Brain Ischemia; China; Cross-Sectional Studies; Diabetes Mellitus, Ty | 2017 |
Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort.
Topics: Aged; Blood Pressure; Brain Ischemia; China; Diastole; Female; Follow-Up Studies; Humans; Hypertensi | 2017 |
Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Chi-Square Distribu | 2017 |
Sex-dependent effects of uric acid on cerebral microbleed: a cross-sectional study in the general population.
Topics: Adult; Aged; Cerebral Hemorrhage; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Imagin | 2017 |
The impact of acute kidney injury on in-hospital mortality in acute ischemic stroke patients undergoing intravenous thrombolysis.
Topics: Acute Kidney Injury; Administration, Intravenous; Aged; Biomarkers; Brain Ischemia; Female; Fibrinol | 2017 |
The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans.
Topics: Aged; Biomarkers; Black People; Brain Ischemia; Cameroon; Chi-Square Distribution; Female; Humans; H | 2018 |
Long-term supplementation with folic acid and vitamin B-12 has no effect on circulating uric acid concentrations in Norwegian patients with coronary artery disease.
Topics: China; Coronary Artery Disease; Folic Acid; Humans; Norway; Primary Prevention; Stroke; Uric Acid; V | 2018 |
Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Mal | 2018 |
Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Cerebrovascular Circulation; Cohort Studies; Cross-Sectional Studi | 2018 |
Hyperuricaemia as a prognostic factor for acute ischaemic stroke.
Topics: Brain Ischemia; Humans; Hyperuricemia; Ischemic Stroke; Prognosis; Stroke; United States; Uric Acid | 2021 |
High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke.
Topics: Brain Ischemia; Demography; Female; Humans; Male; Prognosis; Sex Characteristics; Stroke; Treatment | 2018 |
Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Disability Evaluation; Edaravone; Female; Free | 2018 |
Serum Calcium is Related to the Degree of Artery Stenosis in Acute Ischemic Stroke.
Topics: Adult; Aged; Calcium; Cluster Analysis; Constriction, Pathologic; Databases, Factual; Down-Regulatio | 2018 |
Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats.
Topics: Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Female; Male; Mec | 2018 |
Can high uric acid levels be an independent risk factor for acute ischemic stroke due to large-artery atherosclerosis?
Topics: Atherosclerosis; Bilirubin; Biomarkers; Brain Ischemia; Carotid Intima-Media Thickness; Carotid Sten | 2018 |
Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Carotid Intima-Media Thickness; Carotid Stenosi | 2019 |
Uric acid enhances longevity and endurance and protects the brain against ischemia.
Topics: Animals; Brain; Brain Ischemia; Humans; Longevity; Mice, Transgenic; Oxidative Stress; Stroke; Uric | 2019 |
Is serum uric acid a predictive factor for stroke in men with hypertriglyceridemia?
Topics: Aged; Biomarkers; Humans; Hypertriglyceridemia; Hyperuricemia; Male; Middle Aged; Predictive Value o | 2019 |
Relationship between infarct size and serum uric acid levels during the acute phase of stroke.
Topics: Antioxidants; Female; Fluorescence Recovery After Photobleaching; Humans; Linear Models; Magnetic Re | 2019 |
The prognostic value of serum uric acid in the acute phase of hemorrhagic stroke patients in black Africans.
Topics: Adult; Aged; Black People; Cameroon; Cohort Studies; Female; Follow-Up Studies; Hospitals, General; | 2019 |
Serum Uric Acid Levels and Serum Lipid Levels in Patients with Ischemic Cerebrovascular Accident.
Topics: Aged; Brain Ischemia; Cholesterol, HDL; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Lipi | 2018 |
Serum uric acid and outcome after acute ischemic stroke: PREMIER study.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Chi-Square Distribution; Disability Eval | 2013 |
Association of serum uric acid with ischemic stroke.
Topics: Aged; Brain Ischemia; Comorbidity; Female; Humans; Logistic Models; Male; Middle Aged; Risk Factors; | 2013 |
Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patients.
Topics: Aged; Biomarkers; Brain Ischemia; Cerebral Hemorrhage; China; Down-Regulation; Female; Humans; Kapla | 2014 |
Association of uric acid and carotid artery disease in patients with ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Carotid Intima-Media Thickness; Carotid Stenosis; Female; Humans; Hy | 2014 |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study.
Topics: Aged; Biomarkers; Brain Ischemia; Cohort Studies; Female; Humans; Male; Middle Aged; Norway; Populat | 2013 |
Effects of uric acid levels on outcome in severe ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator.
Topics: Aged; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Recovery of Function; Stroke; Thrombol | 2014 |
Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes.
Topics: Amputation, Surgical; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Body Weight; Cardiovascul | 2014 |
Uric acid for stroke: glimmer of hope or false dawn?
Topics: Antioxidants; Female; Humans; Male; Stroke; Uric Acid | 2014 |
Urate and neuroprotection trials.
Topics: Antioxidants; Female; Humans; Male; Stroke; Uric Acid | 2014 |
Urate and neuroprotection trials--authors' reply.
Topics: Antioxidants; Female; Humans; Male; Stroke; Uric Acid | 2014 |
Correlation of fatigue during the acute stage of stroke with serum uric acid and glucose levels, depression, and disability.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Cross-Sectional Studies; Depression; Disability Evalu | 2014 |
Uric acid for acute stroke: fantasy or reality?
Topics: Animals; Antioxidants; Fantasy; Humans; Stroke; Treatment Outcome; Uric Acid | 2015 |
Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation.
Topics: Aged; Biomarkers; Brain Ischemia; Female; Humans; Male; Recovery of Function; Stroke; Stroke Rehabil | 2015 |
Serum uric acid is neuroprotective in Chinese patients with acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator.
Topics: Aged; Asian People; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Prospective Studies; ROC | 2015 |
Association of uric acid with traditional inflammatory factors in stroke.
Topics: Cross-Sectional Studies; Female; Humans; Inflammation Mediators; Male; Middle Aged; Stroke; Uric Aci | 2016 |
Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain Ischemia; Chi-Square Distrib | 2016 |
Response to Letter Regarding Article, "Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke".
Topics: Antioxidants; Brain Ischemia; Female; Humans; Male; Stroke; Uric Acid | 2015 |
Letter by Heo et al Regarding Article, "Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke".
Topics: Antioxidants; Brain Ischemia; Female; Humans; Male; Stroke; Uric Acid | 2015 |
Low Serum Levels of Uric Acid are Associated With Development of Poststroke Depression.
Topics: Aged; Brain Ischemia; Case-Control Studies; Depressive Disorder; Female; Humans; Male; Middle Aged; | 2015 |
Highly Prevalent Hyperuricaemia is Associated with Adverse Clinical Outcomes Among Ghanaian Stroke Patients: An Observational Prospective Study.
Topics: Aged; Biomarkers; Female; Ghana; Humans; Hyperuricemia; Kaplan-Meier Estimate; Male; Middle Aged; Pr | 2015 |
[Association study of serum uric acid levels with clinical outcome and hemorrhagic transformation in stroke patients with rt-PA intravenous thrombolysis].
Topics: Administration, Intravenous; Brain Ischemia; Fibrinolytic Agents; Humans; Incidence; Intracranial He | 2015 |
Effects of Acute Stroke Serum on Non-Ischemic Cerebral and Mesenteric Vascular Function.
Topics: Acetylcholine; Aged; Animals; C-Reactive Protein; Cerebral Arteries; Dinoprost; Disease Models, Anim | 2016 |
Genetic Causality in Complex Traits: The Case of Uric Acid.
Topics: Coronary Disease; Diabetes Mellitus, Type 2; Humans; Mendelian Randomization Analysis; Polymorphism, | 2016 |
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.
Topics: Coronary Disease; Diabetes Mellitus, Type 2; Global Health; Humans; Mendelian Randomization Analysis | 2016 |
Plasma uric acid concentrations and risk of ischaemic stroke in women.
Topics: Adult; Aged; Brain Ischemia; Case-Control Studies; Cohort Studies; Female; Humans; Hypertension; Mid | 2016 |
Serum Uric Acid Level among Acute Stroke Patients.
Topics: Adult; Aged; Bangladesh; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Risk Factors; S | 2016 |
Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study.
Topics: Adult; Aged; Biomarkers; Chi-Square Distribution; Databases, Factual; Female; Humans; Hyperuricemia; | 2017 |
Plasma uric acid and risk of ischaemic stroke in women.
Topics: Brain Ischemia; Case-Control Studies; Female; Humans; Risk; Risk Factors; Stroke; Uric Acid | 2016 |
[Association between the cardiovascular health score and new-onset atrial fibrillation].
Topics: Atrial Fibrillation; C-Reactive Protein; Humans; Incidence; Multivariate Analysis; Myocardial Infarc | 2016 |
Association of serum uric acid and cardioembolic stroke in patients with acute ischemic stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Cardiovascular Diseases; Female; Humans; Intracranial Embolism; Lo | 2016 |
Interactive effect of serum uric acid and total bilirubin for cardiovascular disease in Chinese patients with type 2 diabetes.
Topics: Aged; Asian People; Bilirubin; Cardiovascular Diseases; China; Cross-Sectional Studies; Diabetes Mel | 2016 |
Uric Acid as a Marker of Mortality and Morbidity in Fabry Disease.
Topics: Adult; Biomarkers; Disease Progression; Fabry Disease; Female; Follow-Up Studies; Humans; Ischemic A | 2016 |
Response to comment on plasma uric acid and risk of ischaemic stroke in women.
Topics: Biomarkers; Brain Ischemia; Female; Humans; Risk; Risk Factors; Stroke; Uric Acid | 2017 |
Lower serum uric acid level strongly predict short-term poor functional outcome in acute stroke with normoglycaemia: a cohort study in China.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; China; Cohort Studies; Diabetes Mellitus; Female; Humans | 2017 |
Uric acid and neuroprotection.
Topics: Animals; Antioxidants; Humans; Hyperuricemia; Neuroprotective Agents; Oxidative Stress; Stroke; Uric | 2008 |
Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study.
Topics: Adult; Cardiovascular Diseases; Female; Humans; Hyperuricemia; Male; Middle Aged; Proportional Hazar | 2009 |
Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS).
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Confidence Intervals; Female; Heart Failure; Humans; Ma | 2009 |
Baseline serum urate and 90-day functional outcomes following acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Female; Humans; Logistic Models; Male; Middle A | 2009 |
Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Female; Humans; Male; Middle Aged; Prognosis; Prospect | 2010 |
Serum bilirubin and uric acid levels as the bad prognostic factors in the ischemic stroke.
Topics: Aged; Analysis of Variance; Bilirubin; Brain Ischemia; Disability Evaluation; Female; Humans; Male; | 2009 |
Decrease in uric acid in acute ischemic stroke correlates with stroke severity, evolution and outcome.
Topics: Acute Disease; Aged; Aged, 80 and over; Brain Ischemia; Disease Progression; Female; Humans; Kinetic | 2010 |
Influence of recanalization on uric acid patterns in acute ischemic stroke.
Topics: Aged; Allantoin; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Oxidative Stress; P | 2010 |
A prediction model for the risk of incident chronic kidney disease.
Topics: Adult; Age Factors; Aged; Asian People; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; | 2010 |
Is elevated SUA associated with a worse outcome in young Chinese patients with acute cerebral ischemic stroke?
Topics: Adult; Asian People; Biomarkers; Female; Humans; Male; Prognosis; Recovery of Function; Stroke; Uric | 2010 |
Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients.
Topics: Adult; Age Factors; Aged; Brain Ischemia; Female; Humans; Inflammation; Kidney Failure, Chronic; Mal | 2011 |
Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis.
Topics: Adult; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Cholesterol; Heart | 2011 |
Translational stroke research of the combination of thrombolysis and antioxidant therapy.
Topics: Antioxidants; Antipyrine; Biomarkers; Edaravone; Fibrinolytic Agents; Humans; Nitrogen Oxides; Oxida | 2011 |
Serum uri acid: neuroprotection in thrombolysis. The Bergen NORSTROKE study.
Topics: Aged; Brain Ischemia; Female; Humans; Male; Neuroprotective Agents; Norway; Outcome and Process Asse | 2011 |
Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cause of Death; Coronary Artery Disease; Co | 2012 |
Lack of association between serum uric acid levels and outcome in acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Humans; Male; Middle Aged; Predictive Value of Test | 2012 |
Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients.
Topics: Biomarkers; Cardiovascular Diseases; Cohort Studies; Essential Hypertension; Female; Follow-Up Studi | 2012 |
24-h residual urine volume at hemodialysis initiation: a possible predictor for acute ischemic stroke incurrence in hemodialysis patients.
Topics: Age Factors; Aged; Brain Ischemia; Cerebral Infarction; Data Interpretation, Statistical; Diabetes C | 2013 |
[Association between serum uric acid and short-term clinical outcome among patients with acute stroke].
Topics: Aged; Female; Humans; Male; Middle Aged; Prognosis; Stroke; Uric Acid | 2012 |
Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cause of Death; Female; Heart Failure; Huma | 2013 |
Serum uric acid independently predicts cardiovascular events in advanced nephropathy.
Topics: Adult; Aged; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Female; | 2012 |
Lack of association between serum uric acid levels and outcome in acute ischemic stroke.
Topics: Brain Ischemia; Female; Humans; Male; Recovery of Function; Stroke; Uric Acid | 2013 |
Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke.
Topics: Aged; Cerebral Hemorrhage; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; Stroke; Ur | 2013 |
Antioxidant capacity after acute ischaemic stroke.
Topics: Acute Disease; Aged; Analysis of Variance; Antioxidants; Biomarkers; Female; Follow-Up Studies; Huma | 2002 |
Uric acid: an important antioxidant in acute ischaemic stroke.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Humans; Rats; Stroke; Uric Acid | 2002 |
[Serum uric acid in type 2 diabetic patients complicated by stroke].
Topics: Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Diabetes Mellitus, Type 2; Female; Humans; Ma | 2002 |
Editorial comment--Elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective.
Topics: Animals; Antioxidants; Brain Ischemia; Causality; Humans; Hypertension; Hyperuricemia; Neuroprotecti | 2003 |
Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke.
Topics: Acute Disease; Aged; Brain Ischemia; Cerebral Hemorrhage; Female; Follow-Up Studies; Humans; Ischemi | 2003 |
HYPERURICAEMIA AND CEREBRAL APOPLEXY.
Topics: Blood; Cerebrovascular Disorders; Humans; Hyperuricemia; Stroke; Uric Acid | 1964 |
Yin and yang of uric acid in patients with stroke.
Topics: Animals; Humans; Hyperuricemia; Prognosis; Rats; Research Design; Risk Factors; Stroke; Treatment Ou | 2004 |
Uric acid administration for neuroprotection in patients with acute brain ischemia.
Topics: Acute Disease; Animals; Antioxidants; Brain Ischemia; Evidence-Based Medicine; Humans; Neuroprotecti | 2004 |
Serum uric acid and risk of death from cancer, cardiovascular disease or all causes in men.
Topics: Adult; Age Factors; Aged; Diabetes Mellitus; Follow-Up Studies; Humans; Korea; Male; Middle Aged; Mu | 2004 |
Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals.
Topics: Acute Disease; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Cholesterol; Female; F | 2005 |
Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects.
Topics: Aged; Apolipoprotein A-I; Brain Ischemia; Case-Control Studies; Cholesterol; Cholesterol, HDL; Diabe | 2005 |
Serum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly subjects.
Topics: Aged; Body Mass Index; Brain Ischemia; Case-Control Studies; Female; Humans; Hypertension; Lipids; M | 2005 |
Serum uric acid and risk of ischemic stroke: the ARIC Study.
Topics: Biomarkers; Brain Ischemia; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Pre | 2006 |
Serum uric acid and long-term mortality from stroke, coronary heart disease and all causes.
Topics: Biomarkers; Cohort Studies; Coronary Disease; Follow-Up Studies; Humans; Male; Middle Aged; Proporti | 2006 |
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Humans; Infarction, Middle Cerebral Artery; Male; Neuro | 2007 |
Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study.
Topics: Aged; Brain Ischemia; Cardiovascular Diseases; Case-Control Studies; Cerebral Hemorrhage; Cohort Stu | 2006 |
Serum uric acid as an independent predictor of early death after acute stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Cerebral Hemorrhage; Cohort Studies; Female; Hospital Morta | 2007 |
Prevalence of and risk factors for peripheral arterial disease in the patients with hypertension among Han Chinese.
Topics: Adult; Aged; Asian People; Blood Pressure; Cardiovascular Diseases; Case-Control Studies; China; Cho | 2007 |
Fatty liver and uric acid levels predict incident coronary heart disease but not stroke among atomic bomb survivors in Nagasaki.
Topics: Aged; Coronary Disease; Fatty Liver; Female; Humans; Japan; Male; Middle Aged; Nuclear Weapons; Pros | 2007 |
Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83,683 Austrian men.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Austria; Biomarkers; Cardiovascular Diseases; Coronary D | 2008 |
The continued yin and yang of uric acid.
Topics: Antioxidants; Humans; Lipid Peroxidation; Severity of Illness Index; Stroke; Treatment Outcome; Uric | 2008 |
Fractional excretion of uric acid as a therapeutic monitor in cerebral salt wasting syndrome.
Topics: Aged; Biomarkers; Brain Diseases; Humans; Hyponatremia; Male; Stroke; Uric Acid; Wasting Syndrome | 2008 |
The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors.
Topics: Acetylcholine; Aged; Arteries; Carotid Arteries; Cholesterol, HDL; Female; Humans; Male; Middle Aged | 2008 |
Hyperuricaemia in Type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Body Mass Index; Coronary Disease; Creatinine; Cross-Sectional Studies; Diabete | 1999 |
Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke.
Topics: Acute Disease; Age Factors; Aged; Antioxidants; Blood Glucose; Blood Sedimentation; Brain Ischemia; | 2002 |
Urate levels as a predictor of cardiac deaths: causal relation or mere association?
Topics: Biomarkers; Death; Humans; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Str | 2002 |
Increase in serum uric acid is selectively associated with stroke in type 2 diabetes.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Stroke; Uric Acid | 2002 |
Lp(a), homocysteine and a family history of early ischemic cerebral stroke.
Topics: Adolescent; Adult; Brain Ischemia; Factor VII; Female; Fibrinogen; Genetic Predisposition to Disease | 2001 |