uric acid has been researched along with Alzheimer Disease in 54 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson's disease dementia (PDD), a meta-analysis was conducted." | 9.41 | Uric acid levels and their association with vascular dementia and Parkinson's disease dementia: a meta-analysis. ( Cen, K; Cui, Y; Feng, X; Hou, X; Li, Q, 2023) |
| "The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database." | 7.83 | Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline? ( Ham, JH; Lee, JJ; Lee, PH; Lee, WW; Sohn, YH; Ye, BS, 2016) |
| "Our findings support that hyperhomocysteinemia is a risk factor for AD in an Algerian population and is also associated with vitamin B12 deficiency." | 7.80 | Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population. ( Belarbi, S; Bendini, M; Chelouti, H; Djerdjouri, B; El Hadi Cherifi, M; Kacimi, G; Khelil, M; Nazef, K; Tazir, M, 2014) |
| "Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs." | 6.82 | Inosine in Neurodegenerative Diseases: From the Bench to the Bedside. ( Basile, MS; Bramanti, P; Mazzon, E, 2022) |
| "However, whether SUA impacts Alzheimer's disease (AD) pathology remains unclear." | 5.62 | Serum Uric Acid May Aggravate Alzheimer's Disease Risk by Affecting Amyloidosis in Cognitively Intact Older Adults: The CABLE Study. ( Bi, YL; Dong, Q; Hou, XH; Hu, H; Li, LL; Ma, YH; Shen, XN; Sun, FR; Tan, L; Xu, W; Yang, JL; Yu, JT, 2021) |
| "To explore the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson's disease dementia (PDD), a meta-analysis was conducted." | 5.41 | Uric acid levels and their association with vascular dementia and Parkinson's disease dementia: a meta-analysis. ( Cen, K; Cui, Y; Feng, X; Hou, X; Li, Q, 2023) |
| "The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database." | 3.83 | Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline? ( Ham, JH; Lee, JJ; Lee, PH; Lee, WW; Sohn, YH; Ye, BS, 2016) |
| "Our findings support that hyperhomocysteinemia is a risk factor for AD in an Algerian population and is also associated with vitamin B12 deficiency." | 3.80 | Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population. ( Belarbi, S; Bendini, M; Chelouti, H; Djerdjouri, B; El Hadi Cherifi, M; Kacimi, G; Khelil, M; Nazef, K; Tazir, M, 2014) |
| "Concentrations of hypoxanthine, xanthine, uric acid and creatinine were measured in CSF of patients suffering form presenile and senile dementia of Alzheimer type (PDAT, SDAT) and multi infarct dementia (MID) and in a reference group of young neurotic patients." | 3.67 | Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type, and in multi infarct dementia. ( Degrell, I; Niklasson, F, 1988) |
| " This article examined the association between long-term use of ULT and cognitive decline among community-dwelling older adults with spontaneous memory complaints." | 3.11 | Association between urate-lowering therapies and cognitive decline in community-dwelling older adults. ( Cantet, C; de Souto Barreto, P; Giudici, KV; Molet-Benhamou, L; Rolland, Y, 2022) |
| "In summary, we propose that Alzheimer's disease may be the consequence of a maladaptation to an evolutionary-based survival pathway and what had served to enhance survival acutely becomes injurious when engaged for extensive periods." | 3.01 | Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? ( Bredesen, D; Burtis, S; Fini, M; Johnson, RJ; Lanaspa, MA; Nagel, M; Perlmutter, D; Sánchez-Lozada, LG; Tolan, DR, 2023) |
| "Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs." | 2.82 | Inosine in Neurodegenerative Diseases: From the Bench to the Bedside. ( Basile, MS; Bramanti, P; Mazzon, E, 2022) |
| "It is known that hyperuricemia is recognized as an independent cardiovascular risk factor." | 2.82 | [The role of hyperuricemia in the development of cognitive changes in the elderly.] ( Ariev, AL; Kunitskaya, NA, 2022) |
| "Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies." | 2.58 | Uric Acid and Cognitive Function in Older Individuals. ( Meschi, T; Nouvenne, A; Prati, B; Tana, C; Ticinesi, A, 2018) |
| "The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence." | 2.53 | Inverse Association Between Serum Uric Acid Levels and Alzheimer's Disease Risk. ( Chen, Y; Du, N; Hou, X; Li, X; Liu, C; Song, X; Wang, Y; Xu, D, 2016) |
| "Uric acid (UA) is an endogenous antioxidant, low levels of which are also implicated in neurodegenerative disease." | 1.91 | The Influence of Agricultural Work and Plasma Uric Acid on Hospital Admission for Alzheimer's Disease. ( Liu, H; Reynolds, GP; Wei, X, 2023) |
| "Uric acid (UA) is an important endogenous antioxidant that protects against oxidative stress, yet its exact role in neurodegeneration remains unclear." | 1.72 | Serum Uric Acid Levels in Neurodegenerative Disorders: A Cross-Sectional Study. ( Aerqin, Q; Chen, KL; Chen, SF; Dong, Q; Huang, YY; Jia, SS; Li, Q; Ou, YN; Shen, XN; Yu, JT, 2022) |
| "However, whether SUA impacts Alzheimer's disease (AD) pathology remains unclear." | 1.62 | Serum Uric Acid May Aggravate Alzheimer's Disease Risk by Affecting Amyloidosis in Cognitively Intact Older Adults: The CABLE Study. ( Bi, YL; Dong, Q; Hou, XH; Hu, H; Li, LL; Ma, YH; Shen, XN; Sun, FR; Tan, L; Xu, W; Yang, JL; Yu, JT, 2021) |
| "Uric acid (UA) is a major contributor to naturally-occurring antioxidant activity and is thought to have protective effects against neurodegenerative processes." | 1.56 | Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer's Disease and Vascular Dementia. ( Liu, H; Reynolds, GP; Wei, X, 2020) |
| "Uric acid (UA) has a contradictory effect on cognitive function and several lines of evidence suggest that UA may modulate outcome in neurological diseases." | 1.42 | Relation between uric acid and Alzheimer's disease in elderly Jordanians. ( Al-khateeb, E; Al-khateeb, M; Al-Musawi, H; Al-Shweiki, S; Althaher, A; Azzouqah, O; Shafagoj, Y, 2015) |
| "Uric acid (UA) is a potent hydrophilic antioxidant that is modified by diet and drug." | 1.36 | Uric acid as a CNS antioxidant. ( Bowman, GL; Frei, B; Kaye, JA; Quinn, JF; Shannon, J, 2010) |
| "The blood redox status of probable Alzheimer's Disease (AD) patients and control subjects with distinct Apo E genotypes was investigated." | 1.30 | Influence of apolipoprotein E genotype on blood redox status of Alzheimer's disease patients. ( Fernandes, AI; Fernandes, MA; Grazina, MM; Nogueira, AJ; Oliveira, CR; Oliveira, LM; Proenca, MT; Santana, I; Santiago, B, 1999) |
| "To study tubular urate transport in Alzheimer's disease (AD) and measure sodium and lithium transport rates in rats exposed to AD plasma." | 1.29 | Hypouricemia, abnormal renal tubular urate transport, and plasma natriuretic factor(s) in patients with Alzheimer's disease. ( Ma, CM; Maesaka, JK; Piccione, JM; Wolf-Klein, G, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.70) | 18.7374 |
| 1990's | 5 (9.26) | 18.2507 |
| 2000's | 9 (16.67) | 29.6817 |
| 2010's | 21 (38.89) | 24.3611 |
| 2020's | 17 (31.48) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, D | 1 |
| Wang, Y | 2 |
| Xu, D | 2 |
| Zhou, G | 1 |
| He, S | 1 |
| Basile, MS | 1 |
| Bramanti, P | 1 |
| Mazzon, E | 1 |
| Ou, YN | 2 |
| Zhao, B | 1 |
| Fu, Y | 1 |
| Sheng, ZH | 1 |
| Gao, PY | 1 |
| Tan, L | 2 |
| Yu, JT | 3 |
| Molet-Benhamou, L | 1 |
| Giudici, KV | 1 |
| de Souto Barreto, P | 1 |
| Cantet, C | 1 |
| Rolland, Y | 1 |
| Aerqin, Q | 1 |
| Jia, SS | 1 |
| Shen, XN | 2 |
| Li, Q | 2 |
| Chen, KL | 1 |
| Huang, YY | 1 |
| Dong, Q | 2 |
| Chen, SF | 1 |
| Şanlı, BA | 1 |
| Whittaker, KJ | 1 |
| Motsi, GK | 1 |
| Shen, E | 1 |
| Julian, TH | 1 |
| Cooper-Knock, J | 1 |
| Kunitskaya, NA | 1 |
| Ariev, AL | 1 |
| Cen, K | 1 |
| Cui, Y | 1 |
| Feng, X | 1 |
| Hou, X | 2 |
| Johnson, RJ | 1 |
| Tolan, DR | 1 |
| Bredesen, D | 1 |
| Nagel, M | 1 |
| Sánchez-Lozada, LG | 1 |
| Fini, M | 1 |
| Burtis, S | 1 |
| Lanaspa, MA | 1 |
| Perlmutter, D | 1 |
| Liu, H | 2 |
| Reynolds, GP | 2 |
| Wei, X | 2 |
| Matsumura, N | 1 |
| Aoyama, K | 1 |
| Wang, Z | 1 |
| Meng, L | 1 |
| Shen, L | 1 |
| Ji, HF | 1 |
| Boccardi, V | 1 |
| Carino, S | 1 |
| Marinelli, E | 1 |
| Lapenna, M | 1 |
| Caironi, G | 1 |
| Bianco, AR | 1 |
| Cecchetti, R | 3 |
| Ruggiero, C | 2 |
| Mecocci, P | 3 |
| Li, LL | 1 |
| Ma, YH | 1 |
| Bi, YL | 1 |
| Sun, FR | 1 |
| Hu, H | 1 |
| Hou, XH | 1 |
| Xu, W | 2 |
| Yang, JL | 1 |
| Qiao, M | 1 |
| Chen, C | 1 |
| Liang, Y | 1 |
| Luo, Y | 1 |
| Wu, W | 1 |
| Lee, YG | 1 |
| Park, M | 1 |
| Jeong, SH | 1 |
| Kang, SW | 1 |
| Baik, K | 1 |
| Jung, JH | 1 |
| Lee, PH | 2 |
| Sohn, YH | 2 |
| Ye, BS | 2 |
| Esteve, C | 1 |
| Jones, EA | 1 |
| Kell, DB | 1 |
| Boutin, H | 1 |
| McDonnell, LA | 1 |
| Pu, Z | 1 |
| Lin, Y | 1 |
| He, J | 1 |
| Huang, M | 1 |
| Schirinzi, T | 1 |
| Di Lazzaro, G | 1 |
| Colona, VL | 1 |
| Imbriani, P | 1 |
| Alwardat, M | 1 |
| Sancesario, GM | 1 |
| Martorana, A | 1 |
| Pisani, A | 1 |
| Zabel, M | 1 |
| Nackenoff, A | 1 |
| Kirsch, WM | 1 |
| Harrison, FE | 1 |
| Perry, G | 1 |
| Schrag, M | 1 |
| Tana, C | 1 |
| Ticinesi, A | 1 |
| Prati, B | 1 |
| Nouvenne, A | 1 |
| Meschi, T | 1 |
| Yuan, H | 1 |
| Yang, W | 1 |
| Williams, DM | 1 |
| Hägg, S | 1 |
| Pedersen, NL | 1 |
| Scheepers, LEJM | 1 |
| Jacobsson, LTH | 1 |
| Kern, S | 1 |
| Johansson, L | 1 |
| Dehlin, M | 1 |
| Skoog, I | 1 |
| McFarland, NR | 1 |
| Burdett, T | 1 |
| Desjardins, CA | 1 |
| Frosch, MP | 1 |
| Schwarzschild, MA | 2 |
| Can, M | 1 |
| Varlibas, F | 1 |
| Guven, B | 1 |
| Akhan, O | 1 |
| Yuksel, GA | 1 |
| Lai, SW | 1 |
| Lin, CL | 1 |
| Liao, KF | 1 |
| Cervellati, C | 1 |
| Romani, A | 1 |
| Seripa, D | 1 |
| Cremonini, E | 1 |
| Bosi, C | 1 |
| Magon, S | 1 |
| Passaro, A | 1 |
| Bergamini, CM | 1 |
| Pilotto, A | 1 |
| Zuliani, G | 1 |
| Nazef, K | 1 |
| Khelil, M | 1 |
| Chelouti, H | 1 |
| Kacimi, G | 1 |
| Bendini, M | 1 |
| Tazir, M | 1 |
| Belarbi, S | 1 |
| El Hadi Cherifi, M | 1 |
| Djerdjouri, B | 1 |
| Chen, X | 1 |
| Guo, X | 1 |
| Huang, R | 1 |
| Chen, Y | 2 |
| Zheng, Z | 1 |
| Shang, H | 1 |
| Al-khateeb, E | 1 |
| Althaher, A | 1 |
| Al-khateeb, M | 1 |
| Al-Musawi, H | 1 |
| Azzouqah, O | 1 |
| Al-Shweiki, S | 1 |
| Shafagoj, Y | 1 |
| Polidori, MC | 2 |
| Croce, MF | 1 |
| Raichi, T | 1 |
| Mangialasche, F | 1 |
| Pelini, L | 1 |
| Paolacci, L | 1 |
| Ercolani, S | 1 |
| Du, N | 1 |
| Song, X | 1 |
| Liu, C | 1 |
| Li, X | 1 |
| Yuan, M | 1 |
| Xu, L | 1 |
| Yin, X | 1 |
| Lee, WW | 1 |
| Ham, JH | 1 |
| Lee, JJ | 1 |
| Irizarry, MC | 1 |
| Raman, R | 1 |
| Becerra, LM | 1 |
| Thomas, RG | 1 |
| Peterson, RC | 1 |
| Ascherio, A | 1 |
| Aisen, PS | 1 |
| Cascalheira, JF | 1 |
| João, SS | 1 |
| Pinhanços, SS | 1 |
| Castro, R | 1 |
| Palmeira, M | 1 |
| Almeida, S | 1 |
| Faria, MC | 1 |
| Domingues, FC | 1 |
| Spitsin, S | 1 |
| Koprowski, H | 1 |
| Bowman, GL | 1 |
| Shannon, J | 1 |
| Frei, B | 1 |
| Kaye, JA | 1 |
| Quinn, JF | 1 |
| Rinaldi, P | 1 |
| Metastasio, A | 1 |
| Mariani, E | 1 |
| Mattioli, P | 1 |
| Cherubini, A | 1 |
| Catani, M | 1 |
| Senin, U | 1 |
| Pulido, R | 1 |
| Jiménez-Escrig, A | 2 |
| Orensanz, L | 1 |
| Saura-Calixto, F | 1 |
| Kim, TS | 1 |
| Pae, CU | 1 |
| Yoon, SJ | 1 |
| Jang, WY | 1 |
| Lee, NJ | 1 |
| Kim, JJ | 1 |
| Lee, SJ | 1 |
| Lee, C | 1 |
| Paik, IH | 1 |
| Lee, CU | 1 |
| Reyes, AJ | 2 |
| Gackowski, D | 1 |
| Rozalski, R | 1 |
| Siomek, A | 1 |
| Dziaman, T | 1 |
| Nicpon, K | 1 |
| Klimarczyk, M | 1 |
| Araszkiewicz, A | 1 |
| Olinski, R | 1 |
| Waugh, WH | 1 |
| Tohgi, H | 1 |
| Abe, T | 1 |
| Takahashi, S | 1 |
| Kikuchi, T | 1 |
| Maesaka, JK | 1 |
| Wolf-Klein, G | 1 |
| Piccione, JM | 1 |
| Ma, CM | 1 |
| Aejmelaeus, R | 1 |
| Ketelä, TM | 1 |
| Pirttilä, T | 1 |
| Hervonen, A | 1 |
| Alho, H | 1 |
| Hensley, K | 1 |
| Maidt, ML | 1 |
| Yu, Z | 1 |
| Sang, H | 1 |
| Markesbery, WR | 1 |
| Floyd, RA | 1 |
| Fernandes, MA | 1 |
| Proenca, MT | 1 |
| Nogueira, AJ | 1 |
| Grazina, MM | 1 |
| Oliveira, LM | 1 |
| Fernandes, AI | 1 |
| Santiago, B | 1 |
| Santana, I | 1 |
| Oliveira, CR | 1 |
| Kasa, M | 1 |
| Bierma, TJ | 1 |
| Waterstraat, F | 1 |
| Corsaut, M | 1 |
| Singh, SP | 1 |
| Degrell, I | 1 |
| Niklasson, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Lutein Influence on Macula of Persons Issued From Amd Parents[NCT01269697] | Phase 3 | 120 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for uric acid and Alzheimer Disease
| Article | Year |
|---|---|
Inosine in Neurodegenerative Diseases: From the Bench to the Bedside.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antioxidants; Humans; Inosine; Multiple Sclerosis; | 2022 |
[The role of hyperuricemia in the development of cognitive changes in the elderly.]
Topics: Aged; Alzheimer Disease; Cognition; Cognitive Dysfunction; Dementia; Dementia, Vascular; Humans; Hyp | 2022 |
Uric acid levels and their association with vascular dementia and Parkinson's disease dementia: a meta-analysis.
Topics: Alzheimer Disease; Dementia; Dementia, Vascular; Humans; Parkinson Disease; Reproducibility of Resul | 2023 |
Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?
Topics: Alzheimer Disease; Fructose; Glucose; Humans; Insulin Resistance; Uric Acid | 2023 |
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Ac | 2023 |
The Influence of Serum Uric Acid Level on Alzheimer's Disease: A Narrative Review.
Topics: Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Humans; Risk Factors; Uric Acid | 2021 |
Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens.
Topics: Alzheimer Disease; Antioxidants; Ascorbic Acid; Biomarkers; Brain; Case-Control Studies; Glutathione | 2018 |
Uric Acid and Cognitive Function in Older Individuals.
Topics: Aged; Alzheimer Disease; Cognition; Cognitive Dysfunction; Dementia; Dementia, Vascular; Disease Pro | 2018 |
Serum uric acid levels in patients with Alzheimer's disease: a meta-analysis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Male; Uric Acid | 2014 |
Inverse Association Between Serum Uric Acid Levels and Alzheimer's Disease Risk.
Topics: Alzheimer Disease; Case-Control Studies; Humans; Publication Bias; Risk Factors; Uric Acid | 2016 |
Role of uric acid in Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Uric Acid | 2010 |
2 trials available for uric acid and Alzheimer Disease
| Article | Year |
|---|---|
Association between urate-lowering therapies and cognitive decline in community-dwelling older adults.
Topics: Aged; Alzheimer Disease; Cognition; Cognitive Dysfunction; Humans; Independent Living; Uric Acid | 2022 |
Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Apolipoproteins E; Ascorbic Acid; Caroteno | 2003 |
41 other studies available for uric acid and Alzheimer Disease
| Article | Year |
|---|---|
Relationship between uric acid and cerebral amyloid angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Amyloid Angiopathy; Cerebral Hemo | 2023 |
The Association of Serum Uric Acid Level, Gout, and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.
Topics: Alzheimer Disease; Genome-Wide Association Study; Gout; Humans; Mendelian Randomization Analysis; Po | 2022 |
Serum Uric Acid Levels in Neurodegenerative Disorders: A Cross-Sectional Study.
Topics: Alzheimer Disease; Cross-Sectional Studies; Frontotemporal Dementia; Humans; Multiple System Atrophy | 2022 |
Unbiased metabolome screen links serum urate to risk of Alzheimer's disease.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Genome-Wide Association Study; Humans; Mendelian R | 2022 |
The Influence of Agricultural Work and Plasma Uric Acid on Hospital Admission for Alzheimer's Disease.
Topics: Alzheimer Disease; Dementia, Vascular; Hospitals; Humans; Neurodegenerative Diseases; Pesticides; Ur | 2023 |
Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer's Disease and Vascular Dementia.
Topics: Aged; Alzheimer Disease; Biomarkers; Brain; Cholesterol, HDL; Dementia, Vascular; Female; Humans; Ma | 2020 |
Impact of modifiable risk factors on Alzheimer's disease: A two-sample Mendelian randomization study.
Topics: Alzheimer Disease; Body Height; Copper; Educational Status; Genome-Wide Association Study; Hippocamp | 2020 |
Uric acid and late-onset Alzheimer's disease: results from the ReGAl 2.0 project.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Female; Humans; Italy | 2021 |
Serum Uric Acid May Aggravate Alzheimer's Disease Risk by Affecting Amyloidosis in Cognitively Intact Older Adults: The CABLE Study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Biomarkers; Cognition; Female; Humans; | 2021 |
Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Apolipoprotein E4; Brain; Cognition; Cogni | 2021 |
Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Disease Models, Animal; H | 2017 |
Oxidative Stress Markers and Metal Ions are Correlated With Cognitive Function in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; C-Reactive Protein; Cations; Ceruloplasmin; | 2017 |
Assessment of serum uric acid as risk factor for tauopathies.
Topics: Aged; Alzheimer Disease; Biomarkers; Female; Frontotemporal Dementia; Humans; Male; Retrospective St | 2017 |
Genetically Determined Serum Uric Acid and Alzheimer's Disease Risk.
Topics: Alzheimer Disease; Female; Genome-Wide Association Study; Humans; Male; Mendelian Randomization Anal | 2018 |
Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Ascorbic Acid; beta Carotene; Case-Control | 2019 |
Urate and risk of Alzheimer's disease and vascular dementia: A population-based study.
Topics: Adult; Alzheimer Disease; Dementia, Vascular; Female; Humans; Longitudinal Studies; Middle Aged; Ris | 2019 |
Postmortem brain levels of urate and precursors in Parkinson's disease and related disorders.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brain; Case-Control Studies; Femal | 2013 |
Ischemia modified albumin and plasma oxidative stress markers in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Case-Control Studies; Female; gamma-Glutamyltransferase; Humans | 2013 |
No association between gout and Alzheimer's disease: results of a case-control study in older people in Taiwan.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Comorbidity; Female; Gout; Humans; | 2013 |
Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia.
Topics: Advanced Oxidation Protein Products; Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Cogni | 2014 |
Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population.
Topics: Aged; Aged, 80 and over; Algeria; Alzheimer Disease; Case-Control Studies; Cholesterol; Female; Foli | 2014 |
Relation between uric acid and Alzheimer's disease in elderly Jordanians.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Female; Geriatrics; Humans; Jordan; | 2015 |
Association of increased carotid intima-media thickness and lower plasma levels of vitamin C and vitamin E in old age subjects: implications for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Ascorbic Acid; Carotid Intima-Media Thickness; Fe | 2015 |
Uric Acid and the Risk of Alzheimer's Disease: Is There an Association?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Male; Middle Aged; Risk; Uric Acid | 2016 |
Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition Disorders; Cognitive Dysfunction; | 2016 |
Plasma urate and progression of mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Boston; Cognition Disorders; Confounding Factors, Epidem | 2009 |
Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; C-Reactive Protein; Case-Control Studies; Estradiol; Fem | 2009 |
Uric acid as a CNS antioxidant.
Topics: Aged; Alzheimer Disease; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Brain; Female; Humans; Ma | 2010 |
Study of plasma antioxidant status in Alzheimer's disease.
Topics: 2-Aminoadipic Acid; Alzheimer Disease; Antioxidants; Apolipoproteins E; Biomarkers; Fluorescence Rec | 2005 |
Decreased plasma antioxidants in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Bilirubin; Biomarkers; Cognition Disorders; Female; Humans; Male; Serum Alb | 2006 |
Potassium-retaining diuretics and incident Alzheimer disease.
Topics: Aldosterone; Alzheimer Disease; Antioxidants; Brain; Humans; Incidence; Kidney; Neuroprotective Agen | 2006 |
Heart failure, dementia, and diuretics: is uric acid involved?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antihypertensive Agents; Cohort Studies; Dementia; Femal | 2006 |
Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Ascorbic Acid | 2008 |
Inhibition of iron-catalyzed oxidations by attainable uric acid and ascorbic acid levels: therapeutic implications for Alzheimer's disease and late cognitive impairment.
Topics: Alzheimer Disease; Antioxidants; Ascorbic Acid; Cognition Disorders; Hemoglobins; Hydrogen Peroxide; | 2008 |
The urate and xanthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type, Alzheimer type dementia, and Parkinson's disease.
Topics: Aged; Alzheimer Disease; Dementia, Multi-Infarct; Dementia, Vascular; Humans; Parkinson Disease; Psy | 1993 |
Hypouricemia, abnormal renal tubular urate transport, and plasma natriuretic factor(s) in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Biological Assay; Case-Control Studies; Creatinine; Cross-Sectiona | 1993 |
Unidentified antioxidant defences of human plasma in immobilized patients: a possible relation to basic metabolic rate.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Ascorbic Acid; Basal Metabolism; Cerebrova | 1997 |
Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Chemistry; Chromatography, High Pressure Li | 1998 |
Influence of apolipoprotein E genotype on blood redox status of Alzheimer's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Apolipoproteins E; Blood Pl | 1999 |
Routine blood chemistry screen: a diagnostic aid for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Chemical Analysis; Dementia; Discriminant Analysis | 1989 |
Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type, and in multi infarct dementia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Creatinine; Dementia; Humans; Hypoxan | 1988 |