uric acid has been researched along with Allergic Encephalomyelitis in 13 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid (UA) is a purine metabolite that selectively inhibits peroxynitrite-mediated reactions implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative diseases." | 7.71 | Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. ( Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV, 2002) |
| "Uric acid (UA), a product of purine metabolism, is a known scavenger of peroxynitrite (ONOO(-)), which has been implicated in the pathogenesis of multiple sclerosis and experimental allergic encephalomyelitis (EAE)." | 7.70 | The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "We investigated the effects of chronic relapsing experimental allergic encephalomyelitis (first attack and first recovery) on uric acid (UR) concentrations in Lewis rat spinal cord." | 7.67 | Increased concentrations of uric acid in the spinal cord of rats with chronic relapsing experimental allergic encephalomyelitis. ( Honegger, CG; Krenger, W; Langemann, H, 1986) |
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 5.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| "Uric acid (UA) is a purine metabolite that selectively inhibits peroxynitrite-mediated reactions implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative diseases." | 3.71 | Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. ( Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV, 2002) |
| "Uric acid (UA), a product of purine metabolism, is a known scavenger of peroxynitrite (ONOO(-)), which has been implicated in the pathogenesis of multiple sclerosis and experimental allergic encephalomyelitis (EAE)." | 3.70 | The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "Uric acid (UA) is a natural scavenger of ONOO(-) that is present at high levels in the sera of humans and other higher order primates relative to most lower mammals." | 1.31 | Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 1.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| "Uric acid was successfully used to treat experimental allergic encephalomyelitis, the mouse model of multiple sclerosis (M." | 1.30 | [Uric acid as a scavenger in oxidative stress]. ( Staub, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| You, Z | 1 |
| Timilshina, M | 1 |
| Jeong, BS | 1 |
| Chang, JH | 1 |
| Spitsin, SV | 6 |
| Scott, GS | 6 |
| Mikheeva, T | 6 |
| Zborek, A | 3 |
| Kean, RB | 7 |
| Brimer, CM | 2 |
| Koprowski, H | 5 |
| Hooper, DC | 8 |
| Fabis, MJ | 1 |
| Phares, TW | 1 |
| Allameh, A | 1 |
| Maleklou, N | 1 |
| Zargari, M | 1 |
| Sanati, MH | 1 |
| Bagasra, O | 1 |
| Marini, JC | 1 |
| Ohnishi, ST | 1 |
| Kean, R | 1 |
| Champion, JM | 2 |
| Sarker, AB | 1 |
| Bobroski, L | 1 |
| Farber, JL | 1 |
| Akaike, T | 1 |
| Maeda, H | 1 |
| Spitsin, S | 1 |
| Dickson, GM | 1 |
| Chaudhry, I | 1 |
| Staub, M | 1 |
| Honegger, CG | 1 |
| Krenger, W | 1 |
| Langemann, H | 1 |
| Rosenthale, ME | 1 |
| Begany, AJ | 1 |
| Dervinis, A | 1 |
| Malis, JL | 1 |
| Shriver, DA | 1 |
| Datko, SL | 1 |
| Gluckman, MI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Multiple Sclerosis Using Over the Counter Inosine[NCT00067327] | Phase 2 | 30 participants | Interventional | 2002-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for uric acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway.
Topics: Aminopyridines; Animals; Benzamides; Cell Differentiation; Cells, Cultured; Encephalomyelitis, Autoi | 2017 |
Comparison of uric acid and ascorbic acid in protection against EAE.
Topics: Albumins; Animals; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Cell Line; Encephalomyelitis, A | 2002 |
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Drug Evaluat | 2002 |
ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity.
Topics: Animals; Blood-Brain Barrier; Chemotaxis, Leukocyte; Disease Models, Animal; Encephalomyelitis, Auto | 2004 |
The influence of uric acid treatments on liver glutathione system prevent oxidative damages in experimental autoimmune encephalomyelitis mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Glutathi | 2008 |
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.
Topics: Animals; Brain; Bridged-Ring Compounds; Cyclic N-Oxides; Encephalomyelitis, Autoimmune, Experimental | 1997 |
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice; Mice, Knockout; Multiple | 1998 |
[Uric acid as a scavenger in oxidative stress].
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Free Rad | 1999 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Expe | 2000 |
Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; F | 2000 |
The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cell Movement; Central Nervous System; Encepha | 2000 |
Increased concentrations of uric acid in the spinal cord of rats with chronic relapsing experimental allergic encephalomyelitis.
Topics: Animals; Blood-Brain Barrier; Encephalomyelitis, Autoimmune, Experimental; Male; Rats; Rats, Inbred | 1986 |
Anti-inflammatory properties of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin).
Topics: Airway Obstruction; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; B | 1974 |