uric acid and Aging
uric acid has been researched along with Aging in 236 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum uric acid (sUA) level may be associated with cognitive impairment/dementia." | 8.93 | Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis. ( Dawson, J; Fan, Y; Hewitt, J; Khan, AA; Quinn, TJ, 2016) |
| "Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension." | 7.91 | Age-differential association between serum uric acid and incident hypertension. ( Ahn, SV; Kim, HC; Lee, HY; Lee, SW; Nam, C; Oh, YA; Suh, I, 2019) |
| "Serum uric acid (UA), which has both antioxidant and pro-oxidant properties, is thought to be involved in cellular aging processes." | 7.91 | Negative Association of Serum URIC Acid with Peripheral Blood Cellular Aging Markers. ( He, S; Li, P; Li, W; Li, Y; Liu, H; Liu, Y; Lv, L; Ma, C; Ma, M; Ping, F; Sun, Q; Xu, L; Yu, J; Zhang, H, 2019) |
| "In patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective." | 7.88 | Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study. ( Bardin, T; Debette, S; Latourte, A; Perez-Ruiz, F; Richette, P; Soumaré, A, 2018) |
| "Although it is known that high uric acid (UA) level is associated with type 2 diabetes (T2DM) and metabolic syndrome (MetS), most of the previous studies were focused on adults." | 7.85 | The Role of Uric Acid for Predicting Future Metabolic Syndrome and Type 2 Diabetes in Older People. ( Chang, JB; Chen, YL; Hsieh, CH; Hung, YJ; Lee, CH; Liang, YJ; Lin, CM; Lin, JD; Pei, D; Wu, CZ, 2017) |
| "Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels." | 7.85 | Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause. ( Myint, KZ; Ohta, H; Yoshikata, R, 2017) |
| "Although serum uric acid (sUA) is not a criterion for diagnosing metabolic syndrome (MetS), many studies have identified a positive association between sUA and MetS in patients of various ages and ethnicities." | 7.83 | The Power of Serum Uric Acid in Predicting Metabolic Syndrome Diminishes With Age in an Elderly Chinese Population. ( Chang, HW; Chen, JH; Chen, YL; Chuang, TJ; Hsieh, CH; Huang, CL; Li, PF; Liu, JS; Pei, D, 2016) |
| "Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated." | 7.83 | Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. ( Abe, M; Katoh, T; Kawamoto, R; Kohara, K; Kumagi, T; Ninomiya, D, 2016) |
| "Some observational studies have suggested that serum uric acid (SUA) levels are one of the determinants of the metabolic syndrome (MetS)." | 7.83 | Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition. ( Bae, JC; Baek, JH; Jee, JH; Jin, SM; Kim, JH; Lee, MK; Yu, TY, 2016) |
| "Several studies have documented an association between serum uric acid (SUA) concentration and cardiac hypertrophy in hypertensive patients; however, the association remains unclear in chronic kidney disease (CKD) patients." | 7.80 | Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease. ( Fukui, A; Ikeda, H; Kitazono, T; Nakayama, M; Oniki, H; Tsuchihashi, T; Tsuruya, K; Ura, Y; Yoshitomi, R, 2014) |
| "Here we quantified the uric acid (UA) levels in 11 tissues and plasma of C57BL/6 male mice to track its turnover during 3 to 30 months of aging." | 7.78 | Uric acid levels in tissues and plasma of mice during aging. ( Ishigami, A; Iwama, M; Kondo, Y; Maruyama, N; Shimokado, K, 2012) |
| " Associations between uric acid (UA), metabolic syndrome (MetS) and carotid IMT have been reported, but findings regarding the relationship have been inconsistent." | 7.78 | Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome. ( Abe, M; Kawamoto, R; Kusunoki, T; Onji, M; Takayama, S, 2012) |
| "The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men." | 7.77 | Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. ( Chang, Y; Cho, J; Guallar, E; Kim, SG; Ryu, S, 2011) |
| " We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults." | 7.75 | Serum uric acid and prehypertension among Chinese adults. ( Liang, J; Qi, L; Song, H; Xue, Y; Zhang, T; Zou, C, 2009) |
| "We examined the association between serum uric acid (SUA) level and the frequency, risk, and cost of gout flares among the elderly." | 7.75 | Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter? ( Cahill, KE; Krishnan, E; Mody, RR; Patel, PA; Tang, J; Wu, EQ; Yu, AP, 2009) |
| "Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension." | 7.73 | Uric acid and the development of hypertension: the normative aging study. ( Gaziano, M; Gumieniak, O; Litonjua, AA; Perlstein, TS; Sparrow, D; Vokonas, PS; Weiss, ST; Williams, GH, 2006) |
| " Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, plasma glucose, body weight and chemiluminescence monitored oxidative stress in broiler chickens." | 7.71 | Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. ( Iqbal, M; Klandorf, H; Rathore, DS; Shi, X; Van Dyke, K, 2001) |
| "Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease." | 7.69 | Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. ( Landsberg, L; Lee, J; Sparrow, D; Vokonas, PS; Weiss, ST, 1995) |
| "In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated." | 7.68 | The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991) |
| "Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age." | 7.68 | Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991) |
| "The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago." | 7.66 | Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981) |
| "Hyperuricemia is a recognized risk factor for cardiovascular diseases." | 6.80 | Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension. ( Chen, YM; Ho, CS; Liu, ZM; Woo, J, 2015) |
| "Hyperuricemia was present in 29% of men and 34% of women." | 5.91 | Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid. ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Laucevičius, A; Rinkūnienė, E; Ryliškytė, L, 2023) |
| "Allantoin is a nonenzymatic oxidative product of uric acid in human." | 5.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
| "Uric acid is a powerful antioxidant and is a scavenger of singlet oxygen and radicals." | 5.26 | Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. ( Ames, BN; Cathcart, R; Hochstein, P; Schwiers, E, 1981) |
| "Although many studies have indicated a relationship between nonalcoholic fatty liver disease (NAFLD) and hyperuricemia, a few studies specifically examining the effects of the severity of liver fat content (LFC) on serum uric acid (SUA) and the presence of hyperuricemia because of the limitation of the examination methods for NAFLD." | 5.20 | Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study. ( Gao, X; Li, Q; Li, X; Lin, H; Liu, X; Ma, H; Pan, B; Wang, D; Wu, J; Xia, M; Zhao, N, 2015) |
| "Serum uric acid (sUA) level may be associated with cognitive impairment/dementia." | 4.93 | Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis. ( Dawson, J; Fan, Y; Hewitt, J; Khan, AA; Quinn, TJ, 2016) |
| "High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e." | 4.91 | The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015) |
| " Carotid-femoral pulse wave velocity (cfPWV), assessed using applanation tonometry, was evaluated as an early vascular aging parameter in patients with hyperuricemia and with normal serum uric acid (sUA) levels." | 4.31 | The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients. ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Kazėnaitė, E; Rinkūnienė, E; Rugienė, R; Ryliškytė, L, 2023) |
| " Hyperuricemia was defined using uric acid levels as > 420 μmol/L and > 350 μmol/L in NHANES for men and women, respectively; in the NILS-LSA, serum uric acid was repeatedly measured at baseline and follow-up surveys." | 4.31 | Mushroom consumption and hyperuricemia: results from the National Institute for Longevity Sciences-Longitudinal Study of Aging and the National Health and Nutrition Examination Survey (2007-2018). ( Ba, DM; Gao, X; Muscat, J; Nishita, Y; Otsuka, R; Qiu, T; Tange, C; Zhang, S, 2023) |
| "Serum uric acid (UA), which has both antioxidant and pro-oxidant properties, is thought to be involved in cellular aging processes." | 3.91 | Negative Association of Serum URIC Acid with Peripheral Blood Cellular Aging Markers. ( He, S; Li, P; Li, W; Li, Y; Liu, H; Liu, Y; Lv, L; Ma, C; Ma, M; Ping, F; Sun, Q; Xu, L; Yu, J; Zhang, H, 2019) |
| "Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension." | 3.91 | Age-differential association between serum uric acid and incident hypertension. ( Ahn, SV; Kim, HC; Lee, HY; Lee, SW; Nam, C; Oh, YA; Suh, I, 2019) |
| "In patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective." | 3.88 | Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study. ( Bardin, T; Debette, S; Latourte, A; Perez-Ruiz, F; Richette, P; Soumaré, A, 2018) |
| "It was shown the alterations in hydrogen sulfide (H(2)S) metabolism and the development of oxidative and nitrozative stress in cardiovascular system by aging." | 3.85 | [PYRIDOXAL-5-PHOSPHATE RESTORES HYDROGEN SULFIDE SYNTHES AND REDOX STATE OF HEART AND BLOOD VESSELS TISSUE IN OLD ANIMALS]. ( Budko, AY; Mys, LA; Sagach, VF; Strutynska, NA, 2017) |
| "Although it is known that high uric acid (UA) level is associated with type 2 diabetes (T2DM) and metabolic syndrome (MetS), most of the previous studies were focused on adults." | 3.85 | The Role of Uric Acid for Predicting Future Metabolic Syndrome and Type 2 Diabetes in Older People. ( Chang, JB; Chen, YL; Hsieh, CH; Hung, YJ; Lee, CH; Liang, YJ; Lin, CM; Lin, JD; Pei, D; Wu, CZ, 2017) |
| "Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels." | 3.85 | Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause. ( Myint, KZ; Ohta, H; Yoshikata, R, 2017) |
| "The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in endothelial function (EF) has been tested only in middle-aged subjects affected by specific diseases." | 3.85 | Uric acid and endothelial function in elderly community-dwelling subjects. ( Aloe, R; Ceda, GP; Cederholm, T; Ferrucci, L; Larsson, A; Lauretani, F; Lind, L; Maggio, M; Meschi, T; Ruggiero, C; Ticinesi, A, 2017) |
| "Some observational studies have suggested that serum uric acid (SUA) levels are one of the determinants of the metabolic syndrome (MetS)." | 3.83 | Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition. ( Bae, JC; Baek, JH; Jee, JH; Jin, SM; Kim, JH; Lee, MK; Yu, TY, 2016) |
| "Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated." | 3.83 | Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. ( Abe, M; Katoh, T; Kawamoto, R; Kohara, K; Kumagi, T; Ninomiya, D, 2016) |
| "Although serum uric acid (sUA) is not a criterion for diagnosing metabolic syndrome (MetS), many studies have identified a positive association between sUA and MetS in patients of various ages and ethnicities." | 3.83 | The Power of Serum Uric Acid in Predicting Metabolic Syndrome Diminishes With Age in an Elderly Chinese Population. ( Chang, HW; Chen, JH; Chen, YL; Chuang, TJ; Hsieh, CH; Huang, CL; Li, PF; Liu, JS; Pei, D, 2016) |
| "Several studies have documented an association between serum uric acid (SUA) concentration and cardiac hypertrophy in hypertensive patients; however, the association remains unclear in chronic kidney disease (CKD) patients." | 3.80 | Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease. ( Fukui, A; Ikeda, H; Kitazono, T; Nakayama, M; Oniki, H; Tsuchihashi, T; Tsuruya, K; Ura, Y; Yoshitomi, R, 2014) |
| " Associations between uric acid (UA), metabolic syndrome (MetS) and carotid IMT have been reported, but findings regarding the relationship have been inconsistent." | 3.78 | Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome. ( Abe, M; Kawamoto, R; Kusunoki, T; Onji, M; Takayama, S, 2012) |
| "The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men." | 3.77 | Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. ( Chang, Y; Cho, J; Guallar, E; Kim, SG; Ryu, S, 2011) |
| " DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities as well as the level of nonenzymatic antioxidants--urea and uric acids, because during organism aging the antioxidant defense systems are being suppressed." | 3.77 | [Mechanism of delta-sleep inducing peptide geroprotective activity]. ( Bondarenko, TI; Maĭboroda, EA; Mikhaleva, II; Prudchenko, IA, 2011) |
| "Epidemiological studies have shown that increased serum uric acid (SUA) level is associated with coronary artery disease (CAD)." | 3.75 | Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burden. ( Boyaci, B; Cemri, M; Cengel, A; Kocaman, SA; Sahinarslan, A; Timurkaynak, T, 2009) |
| " We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults." | 3.75 | Serum uric acid and prehypertension among Chinese adults. ( Liang, J; Qi, L; Song, H; Xue, Y; Zhang, T; Zou, C, 2009) |
| "We examined the association between serum uric acid (SUA) level and the frequency, risk, and cost of gout flares among the elderly." | 3.75 | Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter? ( Cahill, KE; Krishnan, E; Mody, RR; Patel, PA; Tang, J; Wu, EQ; Yu, AP, 2009) |
| "Sarcopenia may be related to increases in reactive oxygen species formation and inflammation, both of which are associated with elevations in serum uric acid." | 3.75 | Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III. ( Beavers, DP; Beavers, KM; Bowden, RG; Serra, MC; Wilson, RL, 2009) |
| " Since uric acid (UA), has strong antioxidant properties, we tested the hypothesis that UA levels is cross-sectionaly associated with muscle strength and protective against the decline of strength over the aging process." | 3.74 | Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons. ( Bandinelli, S; Cecchi, F; Ferrucci, L; Guarducci, L; Guralnik, JM; Lauretani, F; Macchi, C; Molino-Lova, R; Polcaro, P, 2008) |
| "Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension." | 3.73 | Uric acid and the development of hypertension: the normative aging study. ( Gaziano, M; Gumieniak, O; Litonjua, AA; Perlstein, TS; Sparrow, D; Vokonas, PS; Weiss, ST; Williams, GH, 2006) |
| " Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, plasma glucose, body weight and chemiluminescence monitored oxidative stress in broiler chickens." | 3.71 | Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. ( Iqbal, M; Klandorf, H; Rathore, DS; Shi, X; Van Dyke, K, 2001) |
| "Aging is a factor known to increase neuronal vulnerability to oxidative stress, which is widely accepted as a mechanism of manganese-induced neuronal damage." | 3.70 | Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats. ( Delogu, MR; Desole, MS; Esposito, G; Fresu, L; Miele, M; Migheli, R; Rocchitta, G; Serra, PA, 2000) |
| "Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease." | 3.69 | Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. ( Landsberg, L; Lee, J; Sparrow, D; Vokonas, PS; Weiss, ST, 1995) |
| "To determine the effect of aging on renal functions, I measured the concentration of blood urea nitrogen (BUN), serum uric acid and serum creatinine." | 3.69 | [The effects of aging on renal function test]. ( Yoshida, K, 1994) |
| "Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age." | 3.68 | Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991) |
| "In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated." | 3.68 | The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991) |
| " Abnormal angiograms were associated with greater age, treated hypertension, current smoking, and lower hemoglobin levels but with higher uric acid, factor VIII, and fibrinogen concentrations." | 3.67 | Arterial disease risk factors and angiographic evidence of atheroma of the carotid artery. ( Harrison, MJ; Hurst, C; Meade, TW; Schneidau, A; Wilkes, HC, 1989) |
| "The concentration of the free aromatic amino acids tryptophan and tyrosine, the antioxidant uric acid and some unidentified compounds have been determined in the water-soluble extracts of parts from clear and nuclear-cataractous human lenses." | 3.67 | Distribution of aromatic and fluorescent compounds within single human lenses. ( Bessems, GJ; Hoenders, HJ, 1987) |
| " From more than 30 variables examined in multivariate analyses, blood pressure, obesity, cigarette smoking, alcohol consumption, serum glucose, uric acid and triglyceride, were inversely associated with staying healthy while forced vital capacity and years spent in Japan were directly associated with health." | 3.67 | Biological and social predictors of health in an aging cohort. ( Benfante, R; Brody, J; Reed, D, 1985) |
| " With aging, there was a significant increase in plasma glucose, glutamic-oxalacetic transaminase (GOT), potassium, cholesterol, uric acid, and albumin." | 3.66 | Blood parameters of one-year-old and seven-year old partridges (Alectoris chukar). ( Mayeda, B; Vohra, P; Woodard, AE, 1983) |
| "Uric acid levels of adult male volunteers in a longitudinal study of human aging rose steadily between 1961 and 1978." | 3.66 | Trends in serum uric acid levels 1961--1980. ( Campion, EW; Glynn, RJ; Silbert, JE, 1983) |
| "The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago." | 3.66 | Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981) |
| "Forty-seven patients with gout, 28 of whom had not previously been treated with allopurinol, and 25 normal subjects, were examined for 24-h urinary excretion of the most important adrenal steroid derivatives." | 3.66 | Hormonal aspects of human gout--excretion of adrenal hormone derivatives in gouty patients. ( Aleo, MF; Bianchi, E; Ferrari, S; Gregolini, L; Marcolongo, R; Marinello, E, 1983) |
| " cholesterol, triglyceride, uric acid in serum; the number of erythrocytes and the components; obesity and blood pressure." | 3.66 | Serum high density lipoprotein cholesterol: as a cholesterol risk factor index for atherosclerotic diseases. ( Murata, K; Nakazawa, K, 1982) |
| "Hyperuricemia is a recognized risk factor for cardiovascular diseases." | 2.80 | Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension. ( Chen, YM; Ho, CS; Liu, ZM; Woo, J, 2015) |
| " Allopurinol is the most commonly used ULT, but there is no consensus on dosing in renal impairment." | 2.47 | The challenges of gout management in the elderly. ( Jordan, S; Stamp, LK, 2011) |
| "Hyperuricemia was present in 29% of men and 34% of women." | 1.91 | Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid. ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Laucevičius, A; Rinkūnienė, E; Ryliškytė, L, 2023) |
| "Metabolic syndrome was considered a proxy for overall cardiometabolic risk." | 1.48 | Association between serum activin A and metabolic syndrome in older adults: Potential of activin A as a biomarker of cardiometabolic disease. ( Chen, LK; Chou, MY; Kojima, T; Lee, WJ; Liang, CK; Lin, MH; Loh, CH; Peng, LN, 2018) |
| "Uric acid also plays important roles in primates but causes gout when present in excess in humans." | 1.46 | Uric acid, an important antioxidant contributing to survival in termites. ( Iuchi, Y; Matsuura, K; Nitao, M; Sakurai, H; Tasaki, E, 2017) |
| "Uric acid has been associated as a risk factor for cardiovascular disease." | 1.42 | Lower uric Acid linked with cognitive dysfunction in the elderly. ( Arias-Carrión, O; Barraza-Salas, M; Cisneros-Martínez, J; Méndez-Hernández, E; Ruano-Calderón, L; Salas-Pacheco, J; Téllez-Valencia, A, 2015) |
| "Hyperuricemia was defined as serum uric acid (SUA) >420 μmol/L for men, >360 μmol/L for women." | 1.37 | Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese. ( Lou, S; Meng, Z; Ren, X; Zhang, Q, 2011) |
| "Endotracheal infection, septicaemia, and gestational age, rather than antioxidant concentrations, are the most powerful predictors of the development of BPD." | 1.32 | Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies. ( Collard, KJ; Godeck, S; Holley, JE; Quinn, MW, 2004) |
| "Allantoin is a nonenzymatic oxidative product of uric acid in human." | 1.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
| "Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss." | 1.31 | Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. ( Brundin, P; Castilho, RF; DiFiglia, M; Hansson, O; Petersén, A; Przedborski, S; Puschban, Z; Rice, M; Romero, N; Sapp, E; Sulzer, D, 2001) |
| "We analyzed cancer mortality trends in 3282 elderly subjects from two general Italian populations with different life-style patterns taking part in the Cardiovascular Study in the Elderly (CASTEL)." | 1.30 | Cancer mortality trends in two cohorts of elderly people having different life-styles. ( Biasin, R; Casiglia, E; Mazza, A; Pessina, AC; Pizziol, A; Privato, G; Scarpa, R; Sica, E, 1999) |
| "Uric acid is a powerful antioxidant and is a scavenger of singlet oxygen and radicals." | 1.26 | Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. ( Ames, BN; Cathcart, R; Hochstein, P; Schwiers, E, 1981) |
Research
Studies (236)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 85 (36.02) | 18.7374 |
| 1990's | 39 (16.53) | 18.2507 |
| 2000's | 43 (18.22) | 29.6817 |
| 2010's | 61 (25.85) | 24.3611 |
| 2020's | 8 (3.39) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Čypienė, A | 2 |
| Gimžauskaitė, S | 2 |
| Rinkūnienė, E | 2 |
| Jasiūnas, E | 2 |
| Rugienė, R | 1 |
| Kazėnaitė, E | 1 |
| Ryliškytė, L | 2 |
| Badarienė, J | 2 |
| Laucevičius, A | 1 |
| Ba, DM | 1 |
| Zhang, S | 1 |
| Nishita, Y | 1 |
| Tange, C | 1 |
| Qiu, T | 1 |
| Gao, X | 2 |
| Muscat, J | 1 |
| Otsuka, R | 1 |
| García, GO | 1 |
| Paterlini, CA | 1 |
| Hernandez, MM | 1 |
| Behotas, RT | 1 |
| Favero, M | 1 |
| Seco Pon, JP | 1 |
| Liu, J | 1 |
| Yang, W | 1 |
| Li, Y | 4 |
| Wei, Z | 1 |
| Dan, X | 1 |
| Alves, PC | 1 |
| Santos, N | 1 |
| Guo, SM | 1 |
| Liu, YT | 1 |
| He, SR | 1 |
| Wu, MS | 1 |
| Tseng, WT | 1 |
| Wu, RC | 1 |
| Wu, IC | 1 |
| Li, L | 1 |
| Luo, J | 1 |
| Jiang, Y | 1 |
| Zhao, Z | 1 |
| Chen, Y | 2 |
| Huang, Q | 1 |
| Zhang, L | 1 |
| Wu, T | 1 |
| Pang, J | 1 |
| Ya, Z | 1 |
| Fei, L | 1 |
| Yue, Z | 1 |
| Dan, L | 1 |
| Neng-Bo, L | 1 |
| Yi, L | 1 |
| Ying, M | 1 |
| Qin, W | 1 |
| López, J | 1 |
| Waters, M | 1 |
| Routh, A | 1 |
| Rakotonanahary, TF | 1 |
| Woolaver, L | 1 |
| Thomasson, A | 1 |
| Holmes, E | 1 |
| Steinmetz, HW | 1 |
| Tasaki, E | 1 |
| Sakurai, H | 1 |
| Nitao, M | 1 |
| Matsuura, K | 1 |
| Iuchi, Y | 1 |
| Latourte, A | 1 |
| Soumaré, A | 1 |
| Bardin, T | 1 |
| Perez-Ruiz, F | 1 |
| Debette, S | 1 |
| Richette, P | 1 |
| Dye, JA | 1 |
| Gibbs-Flournoy, EA | 1 |
| Richards, JH | 1 |
| Norwood, J | 1 |
| Kraft, K | 1 |
| Hatch, GE | 1 |
| Adamovicz, LA | 1 |
| Trosclair, MR | 1 |
| Lewbart, GA | 1 |
| Kueider, AM | 2 |
| An, Y | 1 |
| Tanaka, T | 2 |
| Kitner-Triolo, MH | 1 |
| Studenski, S | 2 |
| Ferrucci, L | 4 |
| Thambisetty, M | 1 |
| Wang, LX | 1 |
| Filipp, SL | 1 |
| Urbina, EM | 1 |
| Gurka, MJ | 1 |
| DeBoer, MD | 1 |
| Chang, CC | 1 |
| Wu, CH | 1 |
| Liu, LK | 1 |
| Chou, RH | 1 |
| Kuo, CS | 1 |
| Huang, PH | 1 |
| Chen, LK | 2 |
| Lin, SJ | 1 |
| Yang, JJ | 1 |
| Jeong, DH | 1 |
| Lim, YK | 1 |
| Mys, LA | 1 |
| Budko, AY | 1 |
| Strutynska, NA | 1 |
| Sagach, VF | 2 |
| Peng, LN | 1 |
| Chou, MY | 1 |
| Liang, CK | 1 |
| Lee, WJ | 1 |
| Kojima, T | 1 |
| Lin, MH | 1 |
| Loh, CH | 1 |
| Lee, SW | 1 |
| Kim, HC | 1 |
| Nam, C | 1 |
| Lee, HY | 1 |
| Ahn, SV | 1 |
| Oh, YA | 1 |
| Suh, I | 1 |
| Oki, Y | 1 |
| Kawai, M | 1 |
| Minai, K | 1 |
| Ogawa, K | 1 |
| Inoue, Y | 1 |
| Morimoto, S | 1 |
| Nagoshi, T | 1 |
| Ogawa, T | 1 |
| Yoshimura, M | 1 |
| Ratliff, C | 1 |
| Hartup, BK | 1 |
| Yu, J | 1 |
| Liu, H | 1 |
| He, S | 1 |
| Li, P | 1 |
| Ma, C | 1 |
| Ping, F | 1 |
| Zhang, H | 1 |
| Li, W | 1 |
| Sun, Q | 1 |
| Ma, M | 1 |
| Liu, Y | 1 |
| Lv, L | 1 |
| Xu, L | 1 |
| Karimi, F | 1 |
| Dabbaghmanesh, MH | 1 |
| Omrani, GR | 1 |
| Kuroda, Y | 1 |
| Taguchi, K | 1 |
| Enoki, Y | 1 |
| Matsumoto, K | 1 |
| Hori, S | 1 |
| Kizu, J | 1 |
| Ogunro, PS | 1 |
| Ogungbamigbe, TO | 1 |
| Yoshitomi, R | 1 |
| Fukui, A | 1 |
| Nakayama, M | 1 |
| Ura, Y | 1 |
| Ikeda, H | 1 |
| Oniki, H | 1 |
| Tsuchihashi, T | 1 |
| Tsuruya, K | 1 |
| Kitazono, T | 1 |
| Ishii, S | 1 |
| Miyao, M | 1 |
| Mizuno, Y | 1 |
| Tanaka-Ishikawa, M | 1 |
| Akishita, M | 1 |
| Ouchi, Y | 1 |
| Bindler, RC | 1 |
| Daratha, KB | 1 |
| Bindler, RJ | 1 |
| Short, R | 1 |
| Liu, ZM | 1 |
| Ho, CS | 1 |
| Chen, YM | 1 |
| Woo, J | 2 |
| Krishnan, E | 2 |
| Bennett, M | 1 |
| Chen, L | 1 |
| Vannorsdall, TD | 1 |
| Carlson, MC | 1 |
| Schretlen, DJ | 2 |
| Wakuda, H | 1 |
| Uchida, S | 1 |
| Ikeda, M | 1 |
| Tabuchi, M | 1 |
| Akahoshi, Y | 1 |
| Shinozuka, K | 1 |
| Yamada, S | 1 |
| Polidori, MC | 4 |
| Ruggiero, C | 2 |
| Croce, MF | 1 |
| Raichi, T | 1 |
| Mangialasche, F | 1 |
| Cecchetti, R | 3 |
| Pelini, L | 1 |
| Paolacci, L | 1 |
| Ercolani, S | 1 |
| Mecocci, P | 4 |
| Méndez-Hernández, E | 1 |
| Salas-Pacheco, J | 1 |
| Ruano-Calderón, L | 1 |
| Téllez-Valencia, A | 1 |
| Cisneros-Martínez, J | 1 |
| Barraza-Salas, M | 1 |
| Arias-Carrión, O | 1 |
| Cutler, RG | 3 |
| Camandola, S | 1 |
| Malott, KF | 1 |
| Edelhauser, MA | 1 |
| Mattson, MP | 1 |
| Ogura, J | 1 |
| Kuwayama, K | 1 |
| Sasaki, S | 1 |
| Kaneko, C | 1 |
| Koizumi, T | 1 |
| Yabe, K | 1 |
| Tsujimoto, T | 1 |
| Takeno, R | 1 |
| Takaya, A | 1 |
| Kobayashi, M | 1 |
| Yamaguchi, H | 1 |
| Iseki, K | 2 |
| Qu, BG | 1 |
| Wang, H | 1 |
| Liu, YX | 1 |
| Jia, YG | 1 |
| Su, JL | 1 |
| Wang, ZD | 1 |
| Wang, YF | 1 |
| Han, XH | 1 |
| Pan, JD | 1 |
| Lin, H | 2 |
| Li, Q | 1 |
| Liu, X | 1 |
| Ma, H | 1 |
| Xia, M | 1 |
| Wang, D | 1 |
| Li, X | 1 |
| Wu, J | 1 |
| Zhao, N | 1 |
| Pan, B | 1 |
| Drachuk, KO | 1 |
| Dorofeyeva, NA | 1 |
| Kotsjuruba, AV | 1 |
| Kawamoto, R | 2 |
| Katoh, T | 1 |
| Ninomiya, D | 1 |
| Kumagi, T | 1 |
| Abe, M | 3 |
| Kohara, K | 1 |
| Khan, AA | 1 |
| Quinn, TJ | 1 |
| Hewitt, J | 1 |
| Fan, Y | 1 |
| Dawson, J | 1 |
| He, YH | 1 |
| Pu, SY | 1 |
| Xiao, FH | 1 |
| Chen, XQ | 1 |
| Yan, DJ | 1 |
| Liu, YW | 1 |
| Lin, R | 1 |
| Liao, XP | 1 |
| Yu, Q | 1 |
| Yang, LQ | 1 |
| Yang, XL | 1 |
| Ge, MX | 1 |
| Jiang, JJ | 1 |
| Cai, WW | 1 |
| Kong, QP | 1 |
| Yu, TY | 1 |
| Jee, JH | 1 |
| Bae, JC | 1 |
| Jin, SM | 1 |
| Baek, JH | 1 |
| Lee, MK | 1 |
| Kim, JH | 1 |
| Hulsegge, G | 1 |
| Herber-Gast, GC | 1 |
| Spijkerman, AM | 1 |
| Susan, H | 1 |
| Picavet, J | 1 |
| van der Schouw, YT | 1 |
| Bakker, SJ | 1 |
| Gansevoort, RT | 1 |
| Dollé, ME | 1 |
| Smit, HA | 1 |
| Monique Verschuren, WM | 1 |
| Yoshikata, R | 1 |
| Myint, KZ | 1 |
| Ohta, H | 1 |
| Gradinaru, D | 1 |
| Margina, D | 1 |
| Borsa, C | 1 |
| Ionescu, C | 1 |
| Ilie, M | 1 |
| Costache, M | 1 |
| Dinischiotu, A | 1 |
| Prada, GI | 1 |
| Chen, JH | 1 |
| Hsieh, CH | 2 |
| Liu, JS | 1 |
| Chuang, TJ | 1 |
| Chang, HW | 1 |
| Huang, CL | 1 |
| Li, PF | 1 |
| Pei, D | 2 |
| Chen, YL | 2 |
| Xiu, S | 1 |
| Zheng, Z | 1 |
| Guan, S | 1 |
| Zhang, J | 1 |
| Ma, J | 1 |
| Chan, P | 1 |
| Canepa, M | 1 |
| Viazzi, F | 1 |
| Strait, JB | 1 |
| Ameri, P | 1 |
| Pontremoli, R | 1 |
| Brunelli, C | 1 |
| Lakatta, EG | 1 |
| AlGhatrif, M | 1 |
| Sohn, JA | 1 |
| Kim, HS | 1 |
| Oh, J | 1 |
| Cho, JY | 1 |
| Yu, KS | 1 |
| Lee, J | 2 |
| Shin, SH | 1 |
| Lee, JA | 1 |
| Choi, CW | 1 |
| Kim, EK | 1 |
| Kim, BI | 1 |
| Park, EA | 1 |
| Ticinesi, A | 1 |
| Lauretani, F | 2 |
| Ceda, GP | 1 |
| Aloe, R | 1 |
| Larsson, A | 1 |
| Cederholm, T | 1 |
| Lind, L | 1 |
| Meschi, T | 1 |
| Maggio, M | 1 |
| Chang, JB | 1 |
| Hung, YJ | 1 |
| Lee, CH | 1 |
| Lin, JD | 1 |
| Wu, CZ | 1 |
| Liang, YJ | 1 |
| Lin, CM | 1 |
| Macchi, C | 1 |
| Molino-Lova, R | 1 |
| Polcaro, P | 1 |
| Guarducci, L | 1 |
| Cecchi, F | 1 |
| Bandinelli, S | 1 |
| Guralnik, JM | 1 |
| Koga, M | 1 |
| Saito, H | 1 |
| Mukai, M | 1 |
| Kasayama, S | 1 |
| Yamamoto, T | 1 |
| Mallikarjuna, K | 1 |
| Nishanth, K | 1 |
| Hou, CW | 1 |
| Kuo, CH | 1 |
| Sathyavelu Reddy, K | 1 |
| Beavers, KM | 1 |
| Beavers, DP | 1 |
| Serra, MC | 1 |
| Bowden, RG | 1 |
| Wilson, RL | 1 |
| Wu, EQ | 1 |
| Patel, PA | 1 |
| Mody, RR | 1 |
| Yu, AP | 1 |
| Cahill, KE | 1 |
| Tang, J | 1 |
| Cambuli, VM | 1 |
| Incani, M | 1 |
| Pilia, S | 1 |
| Congiu, T | 1 |
| Cavallo, MG | 1 |
| Cossu, E | 1 |
| Sentinelli, F | 1 |
| Mariotti, S | 1 |
| Loche, S | 1 |
| Baroni, MG | 1 |
| Liang, J | 1 |
| Xue, Y | 1 |
| Zou, C | 1 |
| Zhang, T | 1 |
| Song, H | 1 |
| Qi, L | 1 |
| Kocaman, SA | 1 |
| Sahinarslan, A | 1 |
| Cemri, M | 1 |
| Timurkaynak, T | 1 |
| Boyaci, B | 1 |
| Cengel, A | 1 |
| Kayali, R | 1 |
| Aydin, S | 1 |
| Cakatay, U | 1 |
| Peckova, L | 1 |
| Bandouchova, H | 1 |
| Hilscherova, K | 1 |
| Damkova, V | 1 |
| Sedlackova, J | 1 |
| Vitula, F | 1 |
| Paskova, V | 1 |
| Pohanka, M | 1 |
| Kohoutek, J | 1 |
| Pikula, J | 1 |
| Alatalo, P | 1 |
| Koivisto, H | 1 |
| Kultti, J | 1 |
| Bloigu, R | 1 |
| Niemelä, O | 1 |
| Houlihan, LM | 1 |
| Wyatt, ND | 1 |
| Harris, SE | 1 |
| Hayward, C | 1 |
| Gow, AJ | 1 |
| Marioni, RE | 1 |
| Strachan, MW | 1 |
| Price, JF | 1 |
| Starr, JM | 1 |
| Wright, AF | 1 |
| Deary, IJ | 1 |
| Park, KH | 1 |
| Shin, DG | 1 |
| Kim, JR | 1 |
| Cho, KH | 1 |
| Ryu, S | 1 |
| Chang, Y | 1 |
| Kim, SG | 1 |
| Cho, J | 1 |
| Guallar, E | 1 |
| Zhang, Q | 1 |
| Lou, S | 1 |
| Meng, Z | 1 |
| Ren, X | 1 |
| Bondarenko, TI | 1 |
| Maĭboroda, EA | 1 |
| Mikhaleva, II | 1 |
| Prudchenko, IA | 1 |
| Stamp, LK | 1 |
| Jordan, S | 1 |
| Takayama, S | 1 |
| Kusunoki, T | 1 |
| Onji, M | 1 |
| Wonisch, W | 1 |
| Falk, A | 1 |
| Sundl, I | 1 |
| Winklhofer-Roob, BM | 1 |
| Lindschinger, M | 1 |
| Nagaya, T | 1 |
| Kondo, Y | 2 |
| Okinaka, T | 1 |
| Iwama, M | 1 |
| Shimokado, K | 1 |
| Maruyama, N | 1 |
| Ishigami, A | 1 |
| Musso, CG | 1 |
| Juarez, R | 1 |
| Vilas, M | 1 |
| Navarro, M | 1 |
| Rivera, H | 1 |
| Jauregui, R | 1 |
| Jiang, S | 1 |
| Sun, X | 1 |
| Gu, H | 1 |
| Xi, C | 1 |
| Qiao, X | 1 |
| Chen, X | 1 |
| Léa Correa Leite, M | 1 |
| Lima-Costa, MF | 1 |
| Moriguchi, EH | 1 |
| Wu, Y | 1 |
| Zhang, D | 1 |
| Pang, Z | 1 |
| Jiang, W | 1 |
| Wang, S | 2 |
| Tan, Q | 1 |
| Kuzuya, M | 1 |
| Ando, F | 1 |
| Iguchi, A | 1 |
| Shimokata, H | 1 |
| Wu, MT | 1 |
| Kelsey, K | 1 |
| Schwartz, J | 1 |
| Sparrow, D | 4 |
| Weiss, S | 1 |
| Hu, H | 1 |
| Maggio, D | 1 |
| Barabani, M | 1 |
| Pierandrei, M | 1 |
| Catani, M | 1 |
| Senin, U | 3 |
| Pacifici, R | 1 |
| Cherubini, A | 2 |
| GERTLER, MM | 1 |
| OPPENHEIMER, BS | 1 |
| EVERITT, AV | 1 |
| PAUL, AK | 1 |
| CHANDA, R | 1 |
| CHAKRABORTY, BC | 1 |
| TOURNUT, J | 1 |
| MONTLAUR-FERRADOU, P | 1 |
| GEPHARDT, MC | 1 |
| HANLON, TJ | 1 |
| MATSON, CF | 1 |
| BARZEL, US | 1 |
| SPERLING, O | 1 |
| FRANK, M | 1 |
| DEVRIES, A | 1 |
| KUZELL, WC | 1 |
| GLOVER, RP | 1 |
| GIBBS, JO | 1 |
| BLAU, RA | 1 |
| OTT, H | 1 |
| ZAHND, G | 1 |
| ZENDER, R | 1 |
| BEAUMONT, JL | 1 |
| SCHWARTZ, D | 1 |
| MIKKELSEN, WM | 2 |
| DODGE, HJ | 2 |
| VALKENBURG, H | 1 |
| MORGAN, AF | 1 |
| MURAI, M | 1 |
| GILLUM, HL | 1 |
| Yasumasu, T | 1 |
| Takahara, K | 1 |
| Sadayasu, T | 1 |
| Date, H | 1 |
| Isozumi, K | 1 |
| Kouzuma, R | 1 |
| Nakashima, Y | 1 |
| Kohen, R | 2 |
| Oron, M | 1 |
| Zelkowicz, A | 1 |
| Kanevsky, E | 2 |
| Farfouri, S | 1 |
| Wormser, U | 1 |
| Hayashi, N | 1 |
| Togawa, K | 1 |
| Yanagisawa, M | 1 |
| Hosogi, J | 1 |
| Mimura, D | 1 |
| Yamamoto, Y | 1 |
| Zitnanová, I | 1 |
| Korytár, P | 1 |
| Aruoma, OI | 1 |
| Sustrová, M | 1 |
| Garaiová, I | 1 |
| Muchová, J | 1 |
| Kalnovicová, T | 1 |
| Pueschel, S | 1 |
| Duracková, Z | 2 |
| Collard, KJ | 1 |
| Godeck, S | 1 |
| Holley, JE | 1 |
| Quinn, MW | 1 |
| Rodríguez, P | 1 |
| Tortosa, FS | 1 |
| Millán, J | 1 |
| Gortázar, C | 1 |
| Palmer, BF | 1 |
| Moor, E | 1 |
| Shohami, E | 1 |
| Grigoriadis, N | 1 |
| Symeonidou, C | 1 |
| Gil, L | 1 |
| Siems, W | 2 |
| Mazurek, B | 1 |
| Gross, J | 1 |
| Schroeder, P | 1 |
| Voss, P | 2 |
| Grune, T | 1 |
| Hartman, S | 1 |
| Taleb, SA | 1 |
| Geng, T | 1 |
| Gyenai, K | 1 |
| Guan, X | 1 |
| Smith, E | 1 |
| Perlstein, TS | 1 |
| Gumieniak, O | 1 |
| Williams, GH | 1 |
| Vokonas, PS | 3 |
| Gaziano, M | 1 |
| Weiss, ST | 2 |
| Litonjua, AA | 1 |
| Sivonová, M | 1 |
| Tatarková, Z | 1 |
| Dobrota, D | 1 |
| Lehotský, J | 1 |
| Matáková, T | 1 |
| Kaplán, P | 1 |
| Inscore, AB | 1 |
| Jinnah, HA | 1 |
| Rao, V | 1 |
| Gordon, B | 1 |
| Pearlson, GD | 1 |
| Mariani, E | 1 |
| Baggio, G | 1 |
| Deiana, L | 1 |
| Carru, C | 1 |
| Pes, GM | 1 |
| Franceschi, C | 2 |
| Guarrera, M | 1 |
| Rebora, A | 1 |
| De Vos, D | 1 |
| Decuypere, E | 1 |
| Buyse, J | 1 |
| Montoye, HJ | 1 |
| Faulkner, JA | 1 |
| Willis, PW | 1 |
| Block, WD | 1 |
| Ruiz-Torres, A | 1 |
| Tapia, A | 1 |
| Gregolini, L | 1 |
| Ferrari, S | 1 |
| Marcolongo, R | 1 |
| Aleo, MF | 1 |
| Marinello, E | 1 |
| Bianchi, E | 1 |
| Ames, BN | 2 |
| Andreasen, F | 1 |
| Hansen, U | 1 |
| Husted, SE | 1 |
| Mogensen, CE | 1 |
| Woodard, AE | 1 |
| Vohra, P | 1 |
| Mayeda, B | 1 |
| Driver, CJ | 1 |
| Lamb, MJ | 1 |
| Bartolin, R | 1 |
| Bouvenot, G | 1 |
| Delboy, C | 1 |
| Soula, G | 1 |
| Levy, S | 1 |
| Glynn, RJ | 2 |
| Campion, EW | 2 |
| Silbert, JE | 1 |
| Hofman, A | 1 |
| Valkenburg, HA | 1 |
| Reedy, PR | 1 |
| Smith, RC | 2 |
| Cathcart, R | 1 |
| Schwiers, E | 1 |
| Hochstein, P | 1 |
| Murphy, HM | 1 |
| Wideman, CH | 1 |
| Nakazawa, K | 1 |
| Murata, K | 1 |
| Yu, TF | 2 |
| Roboz, J | 1 |
| Reuter, W | 3 |
| Sauer, I | 4 |
| Ries, W | 2 |
| Charrier, M | 1 |
| Daguzan, J | 1 |
| Kinner, B | 1 |
| Cognazzo, A | 1 |
| Grasso, E | 1 |
| Gerbino Promis, PC | 1 |
| Zagnoni, P | 1 |
| Woodbury, MA | 1 |
| Manton, KG | 1 |
| Stallard, E | 1 |
| Goldbourt, U | 1 |
| Medalie, JH | 1 |
| Herman, JB | 1 |
| Neufeld, HN | 1 |
| Stavroulaki-Tsapara, A | 1 |
| Papanayiotou, P | 1 |
| Dontas, AS | 1 |
| Beaglehole, R | 1 |
| Trost, DC | 1 |
| Tamir, I | 1 |
| Kwiterovich, P | 1 |
| Glueck, CJ | 1 |
| Insull, W | 1 |
| Christensen, B | 1 |
| Barnett, YA | 3 |
| King, CM | 3 |
| Desole, MS | 5 |
| Esposito, G | 5 |
| Migheli, R | 4 |
| Fresu, L | 4 |
| Sircana, S | 1 |
| Zangani, D | 1 |
| Miele, M | 5 |
| Miele, E | 3 |
| Landsberg, L | 1 |
| Enrico, P | 2 |
| De Natale, G | 2 |
| Yoshida, K | 1 |
| Swaminathan, R | 1 |
| Cockram, C | 1 |
| Lau, E | 1 |
| Chan, A | 1 |
| van Zoeren-Grobben, D | 1 |
| Lindeman, JH | 1 |
| Houdkamp, E | 1 |
| Brand, R | 1 |
| Schrijver, J | 1 |
| Berger, HM | 1 |
| Grella, G | 1 |
| Tohgi, H | 1 |
| Takahashi, S | 1 |
| Abe, T | 1 |
| Finelli, C | 2 |
| Guarnieri, C | 2 |
| Muscari, C | 2 |
| Ventura, C | 1 |
| Caldarera, CM | 2 |
| Stefanelli, C | 1 |
| Flamigni, F | 1 |
| Meydani, M | 1 |
| Evans, WJ | 1 |
| Handelman, G | 1 |
| Biddle, L | 1 |
| Fielding, RA | 1 |
| Meydani, SN | 1 |
| Burrill, J | 1 |
| Fiatarone, MA | 1 |
| Blumberg, JB | 1 |
| Cannon, JG | 1 |
| Fowkes, FG | 1 |
| Lowe, GD | 1 |
| Rumley, A | 1 |
| Lennie, SE | 1 |
| Smith, FB | 1 |
| Donnan, PT | 1 |
| Jaccard, YB | 1 |
| Gerster, JC | 1 |
| Calame, L | 1 |
| Seaton, K | 1 |
| Sweid, HA | 1 |
| Bagga, A | 1 |
| Vaswani, M | 1 |
| Vasudev, V | 1 |
| Ahuja, RK | 1 |
| Srivastava, RN | 1 |
| Aejmelaeus, RT | 1 |
| Holm, P | 1 |
| Kaukinen, U | 1 |
| Metsä-Ketelä, TJ | 1 |
| Laippala, P | 1 |
| Hervonen, AL | 1 |
| Alho, HE | 1 |
| Bristow-Craig, HE | 1 |
| Gillespie, ES | 1 |
| Funaba, M | 1 |
| Kagiyama, K | 1 |
| Iriki, T | 1 |
| Nilsson, P | 1 |
| Möller, L | 1 |
| Köster, A | 1 |
| Hollnagel, H | 1 |
| Kakino, J | 1 |
| Sato, R | 1 |
| Naito, Y | 1 |
| Navarro-Alarcón, M | 1 |
| de la Serrana, HL | 1 |
| Pérez-Valero, V | 1 |
| López-Martínez, C | 1 |
| Bottje, WG | 1 |
| Beers, KW | 1 |
| Cawthon, D | 1 |
| Tateishi, T | 1 |
| Asoh, M | 1 |
| Yamaguchi, A | 1 |
| Yoda, T | 1 |
| Okano, YJ | 1 |
| Koitabashi, Y | 1 |
| Kobayashi, S | 1 |
| Bailey, TA | 1 |
| Wernery, U | 1 |
| Howlett, J | 1 |
| Naldo, J | 1 |
| Samour, JH | 1 |
| Facino, RM | 1 |
| Carini, M | 1 |
| Aldini, G | 1 |
| Berti, F | 1 |
| Rossoni, G | 1 |
| Bombardelli, E | 1 |
| Morazzoni, P | 1 |
| Morita, K | 1 |
| Maeda, Y | 1 |
| Masuda, M | 1 |
| Kazusaka, A | 1 |
| Imaoka, S | 1 |
| Funae, Y | 1 |
| Fujita, S | 1 |
| Iqbal, M | 2 |
| Probert, LL | 1 |
| Alhumadi, NH | 1 |
| Klandorf, H | 2 |
| Mazza, A | 1 |
| Casiglia, E | 1 |
| Scarpa, R | 1 |
| Sica, E | 1 |
| Biasin, R | 1 |
| Privato, G | 1 |
| Pizziol, A | 1 |
| Pessina, AC | 1 |
| Culleton, BF | 1 |
| Larson, MG | 1 |
| Kannel, WB | 1 |
| Levy, D | 1 |
| Lip, GY | 1 |
| Beevers, M | 1 |
| Beevers, DG | 1 |
| Wakabayashi, I | 1 |
| Troiano, L | 1 |
| Pini, G | 1 |
| Straatman, M | 1 |
| Monti, D | 1 |
| Stahl, W | 1 |
| Sies, H | 1 |
| Benzie, IF | 1 |
| Bowerman, WW | 1 |
| Stickle, JE | 1 |
| Giesy, JP | 1 |
| Serra, PA | 2 |
| Delogu, MR | 2 |
| Rocchitta, G | 2 |
| Thiele, JJ | 1 |
| Schroeter, C | 1 |
| Hsieh, SN | 1 |
| Podda, M | 1 |
| Packer, L | 1 |
| Nakayama, H | 1 |
| Akiyama, S | 1 |
| Inagaki, M | 1 |
| Gotoh, Y | 1 |
| Oguchi, K | 1 |
| Rathore, DS | 1 |
| Shi, X | 1 |
| Van Dyke, K | 1 |
| Garrapa, GG | 1 |
| Pantanetti, P | 1 |
| Arnaldi, G | 1 |
| Mantero, F | 1 |
| Faloia, E | 1 |
| Petersén, A | 1 |
| Hansson, O | 1 |
| Puschban, Z | 1 |
| Sapp, E | 1 |
| Romero, N | 1 |
| Castilho, RF | 1 |
| Sulzer, D | 1 |
| Rice, M | 1 |
| DiFiglia, M | 1 |
| Przedborski, S | 1 |
| Brundin, P | 1 |
| Oshiro, S | 1 |
| Tozawa, M | 1 |
| Iseki, C | 1 |
| Ikemiya, Y | 1 |
| Takishita, S | 1 |
| Hu, P | 1 |
| Seeman, TE | 1 |
| Harris, TB | 1 |
| Reuben, DB | 1 |
| Bancroft, HR | 1 |
| Moore, CA | 1 |
| Frazier, JL | 1 |
| Stricker, CM | 1 |
| Scott, JT | 1 |
| Hewitt, WR | 1 |
| Wagner, PA | 1 |
| Bostwick, EF | 1 |
| Hook, JB | 1 |
| Oreopoulos, DG | 1 |
| Amery, A | 1 |
| Berthaux, P | 1 |
| Birkenhäger, W | 1 |
| Boel, A | 1 |
| Brixko, P | 1 |
| Bulpitt, C | 1 |
| Clement, D | 1 |
| De Padua, F | 1 |
| Deruyttere, M | 1 |
| De Schaepdryver, A | 1 |
| Dollery, C | 1 |
| Fagard, R | 1 |
| Forette, F | 1 |
| Forte, J | 1 |
| Henry, JF | 1 |
| Hellemans, J | 1 |
| Koistinen, A | 1 |
| Laaser, U | 1 |
| Lund-Johansen, P | 1 |
| MacFarlane, J | 1 |
| Miguel, P | 1 |
| Mutsers, A | 1 |
| Nissinen, A | 1 |
| Ohm, OT | 1 |
| Pelemans, W | 1 |
| Suchett-Kaye, AI | 1 |
| Tuomilehto, J | 1 |
| Willems, J | 1 |
| Willemse, P | 1 |
| Kuntz, D | 1 |
| Chrétien, JM | 1 |
| Ryckewaert, A | 1 |
| Isidor, C | 1 |
| Guize, L | 1 |
| Richet, G | 1 |
| Munan, L | 1 |
| Kelly, A | 1 |
| Aldridge, A | 1 |
| Aranda, JV | 1 |
| Neims, AH | 1 |
| Hunecke, I | 2 |
| Seifart, C | 1 |
| Berger, L | 1 |
| McGill, NW | 1 |
| Dieppe, PA | 1 |
| Swan, A | 1 |
| Guerciolini, R | 1 |
| Szumlanski, C | 1 |
| Weinshilboum, RM | 1 |
| Massie, HR | 1 |
| Shumway, ME | 1 |
| Whitney, SJ | 1 |
| Harkness, RA | 1 |
| McCreanor, GM | 1 |
| Greenwood, R | 1 |
| De Jong, JW | 1 |
| van der Meer, P | 1 |
| Huizer, T | 1 |
| Serruys, PW | 1 |
| Bos, E | 1 |
| Roelandt, JR | 1 |
| Gresser, U | 1 |
| Gathof, B | 1 |
| Zöllner, N | 2 |
| Hunter, RE | 1 |
| Barrera, CM | 1 |
| Dohanich, GP | 1 |
| Dunlap, WP | 1 |
| Schneidau, A | 1 |
| Harrison, MJ | 1 |
| Hurst, C | 1 |
| Wilkes, HC | 1 |
| Meade, TW | 1 |
| Boyes, BE | 1 |
| Walker, DG | 1 |
| McGeer, EG | 1 |
| O'Kusky, JR | 1 |
| Bonnacker, I | 1 |
| Berdel, D | 1 |
| Süverkrüp, R | 1 |
| von Berg, A | 1 |
| Khan, MS | 1 |
| Akhtar, P | 1 |
| Majeed, A | 1 |
| Shin, SG | 1 |
| Juan, D | 1 |
| Rammohan, M | 1 |
| Rikans, LE | 1 |
| Moore, DR | 1 |
| Hyams, DE | 1 |
| Bessems, GJ | 1 |
| Hoenders, HJ | 1 |
| Bergström, G | 1 |
| Bjelle, A | 1 |
| Sorensen, LB | 1 |
| Sundh, V | 1 |
| Svanborg, A | 1 |
| Borkan, GA | 1 |
| Wisniewski, C | 1 |
| Miyahara, T | 1 |
| Murai, A | 1 |
| Fujimoto, N | 1 |
| Matsuda, M | 1 |
| Kameyama, M | 1 |
| DeLabry, LO | 1 |
| Saito, K | 1 |
| Furuta, Y | 1 |
| Omatsu, T | 1 |
| Ooshima, T | 1 |
| Nishimura, Y | 1 |
| Takano, S | 1 |
| Fukuzaki, H | 1 |
| Okishio, T | 1 |
| Sano, H | 1 |
| Hirouchi, H | 1 |
| Frantsova, Zh | 1 |
| Zeidler, RB | 1 |
| Metzler, MH | 1 |
| Moran, JB | 1 |
| Kim, HD | 1 |
| Benfante, R | 1 |
| Reed, D | 1 |
| Brody, J | 1 |
| Grenabo, L | 1 |
| Hedelin, H | 1 |
| Pettersson, S | 1 |
| Caird, FI | 1 |
| Rennick, BR | 1 |
| Barrow, MV | 1 |
| Ramsey, HW | 1 |
| Pinckney, ER | 1 |
| Evans, RM | 1 |
| Scholz, RW | 1 |
| Franke, H | 1 |
| Gall, L | 1 |
| Gross, W | 1 |
| Moll, E | 1 |
| Weisshaar, D | 1 |
| Frey, J | 1 |
| Griebsch, A | 1 |
| van Stekelenburg, GJ | 1 |
| Stoop, JW | 1 |
| Krom, ML | 1 |
| Simon, J | 1 |
| Sova, J | 1 |
| Svojgrová, M | 1 |
| Voleníková, L | 1 |
| Rochová, J | 1 |
| Brown, PR | 1 |
| Parks, RE | 1 |
| Lee, PC | 1 |
| Fisher, JR | 1 |
| McInnes, R | 1 |
| Lamm, P | 1 |
| Clow, CL | 1 |
| Scriver, CR | 1 |
| Takenaka, M | 1 |
| Oshima, S | 1 |
| Aoki, N | 1 |
| Kawano, K | 1 |
| Kawai, T | 1 |
| McFarlane, H | 1 |
| Akinkugbe, OO | 1 |
| Adejuwon, AC | 1 |
| Oforofuo, IA | 1 |
| Onayemi, OA | 1 |
| Longe, O | 1 |
| Ojo, OA | 1 |
| Reddy, S | 1 |
| Burcombe, JV | 1 |
| Hollingsworth, MJ | 1 |
| Gatti, A | 2 |
| Scotti, G | 2 |
| Antonini, FM | 1 |
| Fumagalli, C | 1 |
| Sdraffa, L | 1 |
| Sodi Biagioni, A | 1 |
| Chériè Lignière, G | 1 |
| Menozzi, M | 1 |
| Necchi Della Silva, A | 1 |
Clinical Trials (10)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Bogalusa Heart Study[NCT00005129] | 11,737 participants (Actual) | Observational | 1972-06-30 | Active, not recruiting | |||
| Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept[NCT04012294] | Phase 3 | 200 participants (Anticipated) | Interventional | 2019-08-30 | Recruiting | ||
| A Double-blind Randomized Controlled Trial on Whole Soy and Daidzein Supplementation on Reduction of Blood Pressure in Prehypertensive Postmenopausal Chinese Women[NCT01270737] | 270 participants (Anticipated) | Interventional | 2011-03-31 | Not yet recruiting | |||
| The Effects of Soy Protein and/or Isoflavones on Glycemic Control, Insulin Sensitivity and Cardiovascular Risk Factors-a Six Months RCT Among Postmenopausal Women[NCT00856882] | 0 participants | Interventional | 2007-10-31 | Completed | |||
| [NCT00005128] | 0 participants | Observational | 1972-07-31 | Completed | |||
| [NCT00005282] | 0 participants | Observational | 1981-12-31 | Completed | |||
| Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism[NCT01990560] | Phase 4 | 8 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Study Protocol for a Prospective Observational Study Investigating the Role of Luminal Pressure on Arteriovenous Fistula Maturation[NCT04017806] | 60 participants (Anticipated) | Observational | 2018-09-19 | Recruiting | |||
| Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care[NCT05698680] | Phase 4 | 314 participants (Anticipated) | Interventional | 2023-01-18 | Recruiting | ||
| [NCT00005123] | 0 participants | Observational | 1965-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
A1C Level
Change in hyperglycemia assessed by HbA1c, also known as glycated hemoglobin (NCT01990560)
Timeframe: Baseline, 3 months, and 6 months
| Intervention | percentage of red blood cells (Mean) | ||
|---|---|---|---|
| Baseline | 3 months | 6 months | |
| Mifepristone | 6.2 | 6.1375 | 6.125 |
Body Mass Index (BMI)
Change in metabolic syndrome as assessed by BMI (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | kg/m2 (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 35.1538 | 34.5463 |
CushingQoL
Change in Quality of Life - as assessed by the Cushing's Quality of Life questionnaire (CushingQoL). Patient completed questionnaire, 12 items, each scored on a 5 point score, resulting in a score of 12 (worst) to 60 (best) where higher scores indicate more favorable QOL. (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 37.2857 | 38.7857 |
Fasting Lipid Profile
Change in metabolic syndrome as assessed by fasting lipid profile which includes Low-density lipoproteins ( LDL), High-density lipoproteins (HDL), and Triglycerides (Trigs) levels, and total cholesterol which is the sum of HDL plus LDL and 20% of trigs. (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | mg/dL (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Total Cholesterol Baseline | Total Cholesterol 6 months | LDL baseline | LDL 6 months | HDL Baseline | HDL 6 months | Trigs Baseline | Trigs 6 months | |
| Mifepristone | 178.63 | 171.43 | 97.88 | 104.37 | 59.13 | 46.86 | 107.88 | 100.29 |
HOMA-IR
Change in hyperglycemia assessed by Homeostatic Model Assessment of Insulin Resistance, HOMA-IR (a validated assessment of insulin resistance). HOMA-IR = fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5. (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | HOMA-IR score (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 2.418 | 1.465 |
Hospital Anxiety and Depression Scale (HADS)
Change in Quality of Life as assessed by the Hospital Anxiety and Depression Scale (HADS). Questionnaire with 7 items for anxiety and 7 items for depression, each item is scored on a 4 point response 0 - 3, with full range from 0 to 42, with higher score indicating more severe anxiety or depression (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 16.2857 | 11.1667 |
Nottingham Health Profile (NHP)
Change in Quality of Life as assessed by the Nottingham Health Profile (NHP) which is a patient reported questionnaire to measure a patient's view of their own health status. There are 6 sections (Energy level, Pain, Emotional Reaction, Sleep, Social Isolation, and Physical Abilities. All questions have only yes/no answer options and each section score is weighted so that the possible score range for any section is 0-100. The higher the score, the greater the number and severity of problems. (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Energy Level (EL) Baseline | EL 6 months | Pain (P) Baseline | P 6 months | Emotional Reaction (ER) Baseline | ER 6 months | Sleep (S) Baseline | S 6 months | Social Isolation (SI) Baseline | SI 6 months | Physical Abilities (PA) Baseline | PA 6 months | |
| Mifepristone | 32.60 | 45.40 | 24.88 | 32.08 | 27.03 | 35.09 | 24.87 | 31.15 | 20.09 | 31.15 | 23.06 | 27.49 |
Quality of Life
Change in Quality of Life as assessed by the Beck Depression Inventory. a 21-question multiple choice, self-report inventory that is used for measuring the severity of anxiety. Scoring is from a 0 (not at all) to 3 (severe) with a total score range of 0-63. Higher total scores indicate more severe anxiety symptoms. (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 16.1429 | 11.7143 |
State Trait Anxiety Inventory (STAI)
Change in Quality of Life - as assessed by the State Trait Anxiety Inventory (STAI). The State-Trait Anxiety Inventory both state and trait anxiety separately. Each type of anxiety has its own scale of 20 different questions that are scored and averaged. Total scores range from 20 to 80, with higher scores correlating with greater anxiety. (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 25.4286 | 28.8571 |
Waist Circumference
Change in metabolic syndrome as assessed by waist circumference (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | cm (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 103.25 | 99.3125 |
Weight
Change in metabolic syndrome as assessed by weight (NCT01990560)
Timeframe: Baseline and 6 months
| Intervention | kg (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Mifepristone | 99.57 | 97.75 |
Reviews
14 reviews available for uric acid and Aging
| Article | Year |
|---|---|
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom | 2015 |
Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis.
Topics: Aging; Cognition; Cognitive Dysfunction; Dementia; Disease Progression; Humans; Neuropsychological T | 2016 |
The challenges of gout management in the elderly.
Topics: Aged; Aging; Gout; Humans; Uric Acid | 2011 |
Clinical oxidation parameters of aging.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Aldehydes; Amino Acids, Branched-Chain; Antioxidants; Ascorbic A | 2006 |
The detection of environmental mutagens and potential carcinogens.
Topics: Aging; Animals; Biological Assay; Biotransformation; Carcinogens, Environmental; DNA; DNA Repair; Fe | 1984 |
Evolution of antioxidant defence mechanisms.
Topics: Adaptation, Biological; Aging; Antioxidants; Ascorbic Acid; Atmosphere; Biological Evolution; Chroni | 2000 |
The antioxidant network of the stratum corneum.
Topics: Aging; Air Pollutants; Animals; Antioxidants; Arm; Ascorbic Acid; Benzoyl Peroxide; Catalase; Cheek; | 2001 |
New knowledge of the pathogenesis of gout.
Topics: Aging; Complement System Proteins; Crystallization; Endotoxins; Factor XII; Gout; Humans; Hydrogen-I | 1978 |
The elderly patient. A special case for diuretic therapy.
Topics: Aged; Aging; Cerebrovascular Disorders; Diuretics; Heart Failure; Humans; Hyperglycemia; Hyperlipide | 1986 |
[Current aspects of the etiology and pathogenesis of primary gout].
Topics: Adult; Aging; Anaerobiosis; Female; Glycolysis; Gout; Humans; Kidney; Lysosomes; Male; Nutritional P | 1985 |
Antioxidants and longevity of mammalian species.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Body Temperature; Brain; Carotenoids; Catalase; Cerulop | 1985 |
Renal excretion of drugs: tubular transport and metabolism.
Topics: Aging; Aminohippuric Acids; Animals; Biogenic Amines; Biological Transport, Active; Catechols; Cell | 1972 |
Precursors and prevention of coronary artery disease. An overview.
Topics: Aging; Coronary Disease; Diabetes Complications; Diet; Female; Humans; Hypercholesterolemia; Hyperli | 1972 |
The potential toxicity of excessive polyunsaturates. Do not let the patient harm himself.
Topics: Adult; Aging; Coronary Disease; Dietary Fats; Fatty Acids, Unsaturated; Humans; Male; Skin Diseases; | 1973 |
Trials
7 trials available for uric acid and Aging
| Article | Year |
|---|---|
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human | 2015 |
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human | 2015 |
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human | 2015 |
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human | 2015 |
Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study.
Topics: Adipose Tissue; Aged; Aging; China; Female; Humans; Hyperuricemia; Liver; Male; Middle Aged; Non-alc | 2015 |
Postnatal changes in plasma chain-breaking antioxidants in healthy preterm infants fed formula and/or human milk.
Topics: Aging; Antioxidants; Ascorbic Acid; Bilirubin; Humans; Infant Food; Infant, Newborn; Infant, Prematu | 1994 |
Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults.
Topics: Adult; Aged; Aging; Ascorbic Acid; Exercise; Fatty Acids; Humans; Male; Malondialdehyde; Middle Aged | 1993 |
Urinary excretion of minerals, oxalate, and uric acid in north Indian children.
Topics: Adolescent; Aging; Body Height; Body Mass Index; Body Weight; Calcium; Child; Creatinine; Female; Hu | 1997 |
Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome.
Topics: Absorptiometry, Photon; Adipose Tissue; Adrenal Gland Neoplasms; Adult; Aging; Blood Pressure; Body | 2001 |
Antihypertensive therapy in patients above age 60 years (Fourth Interim report of the European Working Party on High Blood pressure in Elderly: EWPHE).
Topics: Aged; Aging; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Doubl | 1978 |
Other Studies
215 other studies available for uric acid and Aging
| Article | Year |
|---|---|
The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients.
Topics: Aging; Blood Pressure; Drinking; Female; Humans; Hyperuricemia; Lithuania; Male; Middle Aged; Pulse | 2023 |
Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid.
Topics: Aging; Alcohol Drinking; Female; Habits; Humans; Hyperuricemia; Male; Metabolic Syndrome; Middle Age | 2023 |
Mushroom consumption and hyperuricemia: results from the National Institute for Longevity Sciences-Longitudinal Study of Aging and the National Health and Nutrition Examination Survey (2007-2018).
Topics: Adult; Agaricales; Aged; Aging; Female; Humans; Hyperuricemia; Longevity; Longitudinal Studies; Male | 2023 |
HEMATOLOGY AND PLASMA CHEMISTRY VALUES IN BEACHED MAGELLANIC PENGUIN (
Topics: Aging; Alkaline Phosphatase; Animals; Animals, Wild; Antibodies, Heterophile; Argentina; Blood Gluco | 2020 |
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.
Topics: Aged; Aged, 80 and over; Aging; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cardiovascu | 2020 |
Sex and Age-Specific Hematology and Biochemistry Reference Intervals of Live Iberian Hares (Lepus granatensis) and Comparison with Postmortem Sampling.
Topics: Aging; Animals; Blood Glucose; Blood Proteins; Calcium; Chlorides; Cholesterol; Erythrocyte Count; E | 2021 |
Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study.
Topics: Aged; Aging; Biomarkers; Cause of Death; Cohort Studies; Female; Hand Strength; Humans; Male; Middle | 2021 |
Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model
Topics: Aging; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Epithelial Cells; Female; Gal | 2021 |
Association between serum gamma-glutamyl transferase and serum uric acid levels in Chinese females: A cross-sectional study.
Topics: Adult; Aged; Aging; Biomarkers; China; Cross-Sectional Studies; Female; gamma-Glutamyltransferase; H | 2017 |
HEMATOLOGY AND PLASMA CHEMISTRY OF THE PLOUGHSHARE TORTOISE (ASTROCHELYS YNIPHORA) IN A CAPTIVE BREEDING PROGRAM.
Topics: Aging; Animal Husbandry; Animals; Blood Cell Count; Breeding; Calcium; Endangered Species; Female; M | 2017 |
Uric acid, an important antioxidant contributing to survival in termites.
Topics: Aging; Animals; Antioxidants; Female; Free Radical Scavengers; Humans; Isoptera; Lipid Peroxidation; | 2017 |
Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study.
Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Brain; Cohort Studies; Dementia; Female; Follow-Up Studi | 2018 |
Neonatal rat age, sex and strain modify acute antioxidant response to ozone.
Topics: Aging; Air Pollutants; Animals; Animals, Newborn; Ascorbic Acid; Body Weight; Female; Glutathione; L | 2017 |
BIOCHEMISTRY PANEL REFERENCE INTERVALS FOR JUVENILE GOLDFISH (CARASSIUS AURATUS).
Topics: Aging; Animals; Aspartate Aminotransferases; Blood Glucose; Calcium; Creatine Kinase; Goldfish; Hema | 2017 |
Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Attention; Brain; Cohort Studies; Executive Function; Female; | 2017 |
Longitudinal Associations of Metabolic Syndrome Severity Between Childhood and Young Adulthood: The Bogalusa Heart Study.
Topics: Adolescent; Adult; Aging; Alabama; Black People; Cardiovascular Diseases; Child; Cross-Sectional Stu | 2018 |
Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study.
Topics: Age Factors; Aged; Aging; Body Mass Index; Cardiovascular Diseases; Carotid Intima-Media Thickness; | 2018 |
Blood Chemistry Reference Values for Free-Ranging Asiatic Black Bears ( Ursus thibetanus) by Season, Age, and Sex.
Topics: Aging; Ammonia; Animals; Bilirubin; Blood Glucose; Blood Urea Nitrogen; Cholesterol; Creatine; Femal | 2018 |
[PYRIDOXAL-5-PHOSPHATE RESTORES HYDROGEN SULFIDE SYNTHES AND REDOX STATE OF HEART AND BLOOD VESSELS TISSUE IN OLD ANIMALS].
Topics: Aging; Animals; Aorta; Cardiotonic Agents; Hydrogen Sulfide; Hydroxyl Radical; Leukotriene C4; Male; | 2017 |
Association between serum activin A and metabolic syndrome in older adults: Potential of activin A as a biomarker of cardiometabolic disease.
Topics: Absorptiometry, Photon; Activins; Aged; Aged, 80 and over; Aging; Biomarkers; Body Mass Index; C-Rea | 2018 |
Age-differential association between serum uric acid and incident hypertension.
Topics: Adult; Age Factors; Aged; Aging; Antihypertensive Agents; Asian People; Blood Pressure; Body Mass In | 2019 |
High Serum Uric Acid is Highly Associated with a Reduced Left Ventricular Ejection Fraction Rather than Increased Plasma B-type Natriuretic Peptide in Patients with Cardiovascular Diseases.
Topics: Aged; Aging; Biomarkers; Cardiac Catheterization; Cardiovascular Diseases; Female; Humans; Male; Mid | 2019 |
Serum Biochemical Analytes and Trace Elements in Juvenile Whooping Cranes (
Topics: Acid-Base Equilibrium; Aging; Alkaline Phosphatase; Animals; Animals, Wild; Aspartate Aminotransfera | 2019 |
Negative Association of Serum URIC Acid with Peripheral Blood Cellular Aging Markers.
Topics: Aging; Biomarkers; Cellular Senescence; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; | 2019 |
Association between serum uric acid and bone health in adolescents.
Topics: Absorptiometry, Photon; Adolescent; Aging; Anthropometry; Biomarkers; Body Mass Index; Bone Density; | 2019 |
Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice.
Topics: Aging; Animals; Male; Mice, Inbred ICR; Theophylline; Uric Acid | 2019 |
Influence of ageing process on body composition of antioxidant and lipid peroxidation among healthy individuals in South West Nigeria.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; alpha-Tocopherol; Antioxidants; Asco | 2013 |
Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease.
Topics: Adult; Aged; Aging; Cardiomegaly; Cross-Sectional Studies; Disease Progression; Echocardiography; Fe | 2014 |
Association between serum uric acid and lumbar spine bone mineral density in peri- and postmenopausal Japanese women.
Topics: Aged; Aging; Bone Density; Female; Humans; Lumbar Vertebrae; Menopause; Middle Aged; Osteoporosis, P | 2014 |
Serum uric acid: relationships with biomarkers in adolescents and changes over 1 year.
Topics: Adolescent; Aging; Anthropometry; Biomarkers; Body Weight; Female; Heart Diseases; Humans; Longitudi | 2014 |
Aging, not menopause, is associated with higher prevalence of hyperuricemia among older women.
Topics: Adult; Aged; Aging; Body Mass Index; Cross-Sectional Studies; Diuretics; Female; Glomerular Filtrati | 2014 |
Higher baseline serum uric acid is associated with poorer cognition but not rates of cognitive decline in women.
Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Cognition; Cognition Disorders; Cohort Studies; Cross-Se | 2014 |
Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice.
Topics: Aging; Allopurinol; Animal Feed; Animals; Apolipoproteins E; Arteriosclerosis; Benzbromarone; Diet; | 2014 |
Association of increased carotid intima-media thickness and lower plasma levels of vitamin C and vitamin E in old age subjects: implications for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Ascorbic Acid; Carotid Intima-Media Thickness; Fe | 2015 |
Lower uric Acid linked with cognitive dysfunction in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Humans; Male; Mental Status Schedule; N | 2015 |
Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
Topics: Aging; Allopurinol; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Ca | 2015 |
Causes of Thickening of Carotid Intima-Media Thickness in Patients With Alcoholic Liver Disease: A Prospective Observational Study.
Topics: Aging; Blood Glucose; Body Mass Index; Carotid Arteries; Carotid Intima-Media Thickness; Cytokines; | 2015 |
[EFFECT OF PROPARGYLGLYCINE UPON CARDIOHEMODYNAMICS IN OLD RATS].
Topics: Adenosine Triphosphate; Aging; Alkynes; Animals; Blood Pressure; Diastole; Glycine; Heart Atria; Hyd | 2015 |
Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women.
Topics: Aged; Aging; Exercise Therapy; Female; Humans; Independent Living; Insulin Resistance; Japan; Middle | 2016 |
Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.
Topics: Adult; Aged; Aged, 80 and over; Aging; Asian People; Blood Pressure; Blood Urea Nitrogen; China; Cho | 2016 |
Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition.
Topics: Aging; Blood Glucose; Blood Pressure; Body Composition; Body Mass Index; Female; Follow-Up Studies; | 2016 |
Obesity and Age-Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations.
Topics: Adult; Aged; Aging; Biomarkers; Blood Pressure; Body Mass Index; C-Reactive Protein; Cholesterol, HD | 2016 |
Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause.
Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Aging; Arachidonic Acid; C-Reactive Protein; Collage | 2017 |
Adiponectin: possible link between metabolic stress and oxidative stress in the elderly.
Topics: Adiponectin; Aged; Aging; Biomarkers; Case-Control Studies; Cholesterol, HDL; Female; Humans; Insuli | 2017 |
The Power of Serum Uric Acid in Predicting Metabolic Syndrome Diminishes With Age in an Elderly Chinese Population.
Topics: Aged; Aged, 80 and over; Aging; Asian People; Cross-Sectional Studies; Female; Humans; Longitudinal | 2016 |
Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing.
Topics: Aged; Aged, 80 and over; Aging; Beijing; Cognition; Cognition Disorders; Cross-Sectional Studies; Fe | 2017 |
Longitudinal Association Between Serum Uric Acid and Arterial Stiffness: Results From the Baltimore Longitudinal Study of Aging.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Baltimore; Biomarkers; Blood Pressure; Cardiovas | 2017 |
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants.
Topics: Aging; Apnea; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Female; Genotype; Gestational Age; Hum | 2017 |
Uric acid and endothelial function in elderly community-dwelling subjects.
Topics: Acetylcholine; Aged; Aging; Biomarkers; Brachial Artery; Cardiovascular Diseases; Endothelium, Vascu | 2017 |
The Role of Uric Acid for Predicting Future Metabolic Syndrome and Type 2 Diabetes in Older People.
Topics: Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; | 2017 |
Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons.
Topics: Aged; Aged, 80 and over; Aging; Female; Follow-Up Studies; Hand Strength; Humans; Male; Muscle, Skel | 2008 |
Factors contributing to increased serum urate in postmenopausal Japanese females.
Topics: Adult; Aging; Alcohol Drinking; Body Mass Index; Female; Homeostasis; Humans; Insulin Resistance; Ja | 2009 |
Effect of exercise training on ethanol-induced oxidative damage in aged rats.
Topics: Aging; Alcohol Drinking; Animals; Antioxidants; Ascorbic Acid; Central Nervous System Depressants; E | 2009 |
Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Female; Health Status; Health Survey | 2009 |
Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter?
Topics: Aged; Aging; Blood Chemical Analysis; Female; Gout; Gout Suppressants; Health Expenditures; Humans; | 2009 |
Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes.
Topics: Adolescent; Aging; Blood Glucose; Body Mass Index; Child; Cohort Studies; Diabetes Mellitus, Type 1; | 2009 |
Serum uric acid and prehypertension among Chinese adults.
Topics: Adiposity; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Asian People; Blood Glucose; China; Fe | 2009 |
Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burden.
Topics: Adult; Aged; Aging; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female; | 2009 |
Effect of gender on main clinical chemistry parameters in aged rats.
Topics: Aging; Albumins; Animals; Antioxidants; Bilirubin; Female; Homeostasis; Iron; Lipids; Male; Models, | 2009 |
Biochemical responses of juvenile and adult Japanese quails to cyanobacterial biomass.
Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Biomass; Blood Glucose; Cholesterol, HDL; Coturn | 2009 |
Evaluation of reference intervals for biomarkers sensitive to alcohol consumption, excess body weight and oxidative stress.
Topics: Adolescent; Adult; Aging; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Bioma | 2010 |
Variation in the uric acid transporter gene (SLC2A9) and memory performance.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Body Mass Index; Child; Cognition; Female; Genetic Vari | 2010 |
Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity.
Topics: Aged; Aging; Antioxidants; Apolipoprotein A-I; Apolipoprotein C-III; Aryldialkylphosphatase; Cholest | 2010 |
Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men.
Topics: Adult; Aging; Alcohol Drinking; Blood Chemical Analysis; Body Mass Index; Fatty Liver; Follow-Up Stu | 2011 |
Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese.
Topics: Adult; Aging; Asian People; Body Mass Index; China; Cross-Sectional Studies; Female; Humans; Hyperur | 2011 |
[Mechanism of delta-sleep inducing peptide geroprotective activity].
Topics: Aging; Animals; Antioxidants; Body Weight; Brain; Ceruloplasmin; Delta Sleep-Inducing Peptide; Eryth | 2011 |
Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Asian People; Biomarkers; Carotid Artery Diseases; Caro | 2012 |
Oxidative stress increases continuously with BMI and age with unfavourable profiles in males.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Autoantibodies; Bilirubin; Body Mass Index; Chole | 2012 |
Serum dehydroepiandrosterone-sulfate reflects age better than health status, and may increase with cigarette smoking and alcohol drinking in middle-aged men.
Topics: Adult; Aging; Alcohol Drinking; Biomarkers; Dehydroepiandrosterone Sulfate; Exercise; Health Status; | 2012 |
Uric acid levels in tissues and plasma of mice during aging.
Topics: Aging; Animals; Male; Mice; Mice, Inbred C57BL; Uric Acid | 2012 |
Renal calcium, phosphorus, magnesium and uric acid handling: comparison between stage III chronic kidney disease patients and healthy oldest old.
Topics: Adult; Aged; Aged, 80 and over; Aging; Calcium; Case-Control Studies; Creatinine; Female; Glomerular | 2012 |
Age-related change in kidney function, its influencing factors, and association with asymptomatic carotid atherosclerosis in healthy individuals--a 5-year follow-up study.
Topics: Age Factors; Aged; Aging; Blood Pressure; Carotid Artery Diseases; China; Cholesterol, LDL; Cross-Se | 2012 |
Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambuì Cohort Study of Ageing (1997-2008).
Topics: Aged; Aged, 80 and over; Aging; Alleles; Apolipoproteins E; Blood Pressure; Brazil; Cohort Studies; | 2013 |
Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50-74 years.
Topics: Aged; Aging; China; Cognition; Cognition Disorders; Cross-Sectional Studies; Disease Progression; Fe | 2013 |
Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group.
Topics: Adult; Age Factors; Aging; Alcohol Drinking; Body Mass Index; Cohort Studies; Female; Follow-Up Stud | 2002 |
A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Bone and Bones; Creatinine; Cross-Sectional Studies; Environm | 2003 |
Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.
Topics: Activities of Daily Living; Aged; Aging; Antioxidants; Ascorbic Acid; Body Mass Index; Bone and Bone | 2003 |
Serum uric acid levels in men and women past the age of 65 years.
Topics: Aged; Aging; Female; Humans; Male; Uric Acid | 1953 |
The urinary excretion of protein, non-protein nitrogen, creatinine and uric acid in ageing male rats.
Topics: Aging; Animals; Body Fluids; Creatinine; Male; Nitrogen; Proteinuria; Rats; Uric Acid | 1958 |
Factors affecting the composition of chicken blood and tissues.
Topics: Aging; Animals; Bone and Bones; Chickens; Cholesterol; Growth; Humans; Intestines; Kidney; Lipids; L | 1962 |
[Blood uric acid of chickens. Variations as a function of age and diet].
Topics: Aging; Animals; Chickens; Diet; Humans; Meat; Poultry; Uric Acid | 1962 |
BLOOD URIC ACID VALUES AS RELATED TO SEX AND AGE.
Topics: Aging; Blood; Humans; Research; Sex; Statistics as Topic; Uric Acid | 1964 |
RENAL AMMONIUM EXCRETION AND URINARY PH IN IDIOPATHIC URIC ACID LITHIASIS.
Topics: Aging; Ammonium Chloride; Ammonium Compounds; Biomedical Research; Geriatrics; Humans; Hydrogen-Ion | 1964 |
EFFECT OF SULFINPYRAZONE ON SERUM URIC ACID IN GOUT. A LONG-TERM STUDY.
Topics: Adolescent; Aging; Blood; Drug Therapy; Geriatrics; Gout; Longitudinal Studies; Metabolism; Phenylbu | 1964 |
[DETERMINATION OF BLOOD URIC ACID IN NORMAL SUBJECTS BY THE URICASE METHOD; VARIATIONS AS A FUNCTION OF AGE AND SEX].
Topics: Aging; Biometry; Blood; Colorimetry; Humans; Sex; Spectrophotometry; Statistics as Topic; Urate Oxid | 1964 |
[BLOOD CHOLESTEROL AND TRIGLYCERIDES IN 2 OCCUPATIONAL GROUPS. FIRST RESULTS OF AN EPIDEMIOLOGIC INVESTIGATION ON THE FACTORS OF ATHEROSCLEROSIS].
Topics: Adolescent; Aging; Arteriosclerosis; Atherosclerosis; Blood; Blood Pressure; Body Weight; Cholestero | 1964 |
THE DISTRIBUTION OF SERUM URIC ACID VALUES IN A POPULATION UNSELECTED AS TO GOUT OR HYPERURICEMIA: TECUMSEH, MICHIGAN 1959-1960.
Topics: Aging; Blood Chemical Analysis; Gout; Humans; Hyperuricemia; Mass Screening; Michigan; Sex; Uric Aci | 1965 |
Nutritional status of the aging. VI. Serum protein, blood nonprotein nitrogen, uric acid and creatinine.
Topics: Aged; Aging; Blood; Blood Proteins; Creatinine; Humans; Nitrogen; Nutritional Status; Uric Acid | 1955 |
Influence of coronary artery disease risk factors on baroreflex sensitivity in the elderly.
Topics: Activities of Daily Living; Aged; Aging; Alcohol Drinking; Baroreflex; Blood Cell Count; Blood Gluco | 2003 |
Low molecular weight antioxidants released from the skin's epidermal layers: an age dependent phenomenon in the rat.
Topics: Adult; Aging; Animals; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; Electrophy | 2004 |
Effect of sunlight exposure and aging on skin surface lipids and urate.
Topics: Aging; Chromatography, High Pressure Liquid; Environmental Exposure; Epidermis; Fatty Acids, Noneste | 2003 |
Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
Topics: Adolescent; Aging; Allantoin; Antioxidants; Child; Chromatography, High Pressure Liquid; Down Syndro | 2004 |
Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies.
Topics: Aging; Antioxidants; Ascorbic Acid; Bronchoalveolar Lavage Fluid; Bronchopulmonary Dysplasia; Cohort | 2004 |
Plasma chemistry reference values from captive red-legged partridges (Alectoris rufa).
Topics: Aging; Animals; Blood Glucose; Blood Proteins; Body Weight; Cholesterol; Creatinine; Female; Gallifo | 2004 |
Disturbances in renal autoregulation and the susceptibility to hypertension-induced chronic kidney disease.
Topics: Aging; Animals; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Fetal Growth Retar | 2004 |
Impairment of the ability of the injured aged brain in elevating urate and ascorbate.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Axons; Brain Injuries; Corpus Callosum; Extracellular M | 2006 |
Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aldehydes; Biomarkers; Erythrocytes; Female; Glut | 2006 |
Comparison of plasma uric acid levels in five varieties of the domestic turkey, Meleagris gallopavo.
Topics: Aging; Animals; Female; Male; Turkeys; Uric Acid | 2006 |
Uric acid and the development of hypertension: the normative aging study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Follow-Up Studies; Humans; Hypertension; Hyperuricemia; Longi | 2006 |
Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats.
Topics: Aging; Animals; Antioxidants; Chromans; Comet Assay; DNA; Heart; Lipid Metabolism; Lymphocytes; Male | 2007 |
Serum uric acid and cognitive function in community-dwelling older adults.
Topics: Aged; Aged, 80 and over; Aging; Body Mass Index; Cognition; Female; Geriatric Assessment; Humans; Ma | 2007 |
Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity.
Topics: Aged; Aged, 80 and over; Aging; Antioxidants; Ascorbic Acid; Female; Glutathione Peroxidase; Humans; | 2007 |
Serum antioxidant capacity in polymorphic light eruption.
Topics: Adult; Aged; Aging; Ascorbic Acid; Bilirubin; Case-Control Studies; Female; Glutathione; Humans; Mal | 2007 |
Dynamic changes in parameters of redox balance after mild heat stress in aged laying hens (Gallus gallus domesticus).
Topics: Acute Disease; Age Factors; Aging; Animals; Antioxidants; Biomarkers; Blood Glucose; Body Temperatur | 2008 |
Serum uric acid concentration among business executives. With observations on other coronary heart disease risk factors.
Topics: Adult; Aging; Alcoholic Beverages; Body Constitution; Cholesterol; Coronary Disease; Humans; Male; M | 1967 |
[Aging as inversion of growth: reaction of uric acid (author's transl)].
Topics: Adult; Aged; Aging; Female; Humans; Male; Middle Aged; Nucleic Acids; Sex Factors; Uric Acid | 1981 |
Hormonal aspects of human gout--excretion of adrenal hormone derivatives in gouty patients.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aging; Allopurinol; Androsterone; Dehydroepiandrosterone; Etio | 1983 |
The influence of intravenous furosemide on the renal excretion pattern of protein and protein degradation products.
Topics: Aged; Aging; Albuminuria; beta 2-Microglobulin; Creatine; Furosemide; Humans; Hydrogen-Ion Concentra | 1984 |
Urate and ascorbate: their possible roles as antioxidants in determining longevity of mammalian species.
Topics: Aging; Animals; Ascorbic Acid; Brain; Energy Metabolism; Feeding Behavior; Free Radicals; Humans; Lo | 1984 |
Blood parameters of one-year-old and seven-year old partridges (Alectoris chukar).
Topics: Aging; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Birds; Blood Glucose; Blood Prote | 1983 |
Metabolic changes in ageing Drosophila melanogaster.
Topics: Aging; Animals; Dietary Carbohydrates; Dietary Fats; Drosophila melanogaster; Feces; Glycogen; Male; | 1980 |
[Blood uric acid and coronary disease. Direct role or statistical relation to lipid disorders].
Topics: Adult; Aged; Aging; Coronary Disease; Female; Humans; Lipids; Male; Middle Aged; Sex Factors; Uric A | 1981 |
Trends in serum uric acid levels 1961--1980.
Topics: Adult; Aged; Aging; Alcohol Drinking; Body Weight; Diet; Humans; Longitudinal Studies; Male; Middle | 1983 |
Determinants of change in blood pressure during childhood.
Topics: Adolescent; Adult; Aging; Blood Pressure; Blood Pressure Determination; Body Height; Body Weight; Ch | 1983 |
Synthesis of 3-N-ribosyluric acid 5'-monophosphate by red cells of the bovine fetus.
Topics: Aging; Animals; Cattle; Erythrocytes; Female; Fetus; Orotate Phosphoribosyltransferase; Pregnancy; R | 1983 |
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
Topics: Adult; Aging; Animals; Antioxidants; Ascorbic Acid; Biological Evolution; Brain; Digestive System; E | 1981 |
Basic alterations in serum levels of several chemical substances in Brattleboro rats.
Topics: Aging; Alkaline Phosphatase; Animals; Blood Glucose; Blood Proteins; Creatinine; Diabetes Insipidus; | 1982 |
Serum high density lipoprotein cholesterol: as a cholesterol risk factor index for atherosclerotic diseases.
Topics: Aging; Arteriosclerosis; Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Coronary Dise | 1982 |
Long-term follow-up of incorporation of 15N from glycine into uric acid in gout.
Topics: Adult; Aged; Aging; Follow-Up Studies; Glycine; Gout; Humans; Male; Middle Aged; Nitrogen; Nitrogen | 1981 |
[Serum uric acid - the longitudinal behavior and age (author's transl)].
Topics: Adult; Aged; Aging; Body Weight; Cholesterol; Female; Humans; Longitudinal Studies; Male; Middle Age | 1980 |
[Nitrogen excretion of Helix aspersa Müller (Mollusca Gastropoda Pulmonata)].
Topics: Aging; Ammonia; Animals; Helix, Snails; Nitrogen; Seasons; Urate Oxidase; Urea; Urease; Uric Acid | 1980 |
[Metabolic risk factors in the very old].
Topics: Aged; Aging; Cardiovascular Diseases; Coronary Disease; Diabetes Complications; Female; Humans; Hype | 1981 |
[Frequency of risk factors in cerebrovascular disease and their effect on the course and outcome. Study on 423 hospitalized patients].
Topics: Aged; Aging; Arrhythmias, Cardiac; Cerebrovascular Disorders; Coronary Disease; Diabetes Complicatio | 1981 |
A dynamic analysis of chronic disease development: a study of sex specific changes in coronary heart disease incidence and risk factors in Framingham.
Topics: Adult; Aging; Blood Pressure; Cholesterol; Coronary Disease; Female; Humans; Longitudinal Studies; M | 1981 |
Serum uric acid: correlation with biochemical, anthropometric, clinical and behavioral parameters in 10,000 Israeli men.
Topics: Adult; Aging; Anthropometry; Coronary Disease; Diabetes Mellitus; Epidemiologic Methods; Ethnicity; | 1980 |
Urate excretion in old age.
Topics: Aged; Aging; Bacteriuria; Female; Humans; Male; Middle Aged; Uric Acid | 1980 |
Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study.
Topics: Adolescent; Adult; Aging; Body Height; Body Weight; Child; Cholesterol; Creatinine; Diet; Female; He | 1980 |
An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans.
Topics: Adult; Aged; Aging; Antioxidants; Bilirubin; Catalase; Ceruloplasmin; DNA Damage; DNA Repair; DNA, S | 1995 |
Cellular defence mechanisms in the striatum of young and aged rats subchronically exposed to manganese.
Topics: Aging; Animals; Ascorbic Acid; Dopamine; Glutathione; Male; Manganese Poisoning; Neostriatum; Oxidat | 1995 |
Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Anthropometry; Body Constitution; Cohort St | 1995 |
Oxidative stress and human ageing.
Topics: Adult; Age Factors; Aged; Aging; Antioxidants; Bilirubin; Cells, Cultured; Chromosome Aberrations; D | 1995 |
Monoaminergic systems activity and cellular defense mechanisms in the brainstem of young and aged rats subchronically exposed to manganese.
Topics: Aging; Animals; Biogenic Monoamines; Biomarkers; Brain Stem; Chlorides; Dehydroascorbic Acid; Drug A | 1994 |
[The effects of aging on renal function test].
Topics: Adult; Aged; Aging; Blood Urea Nitrogen; Creatinine; Female; Humans; Kidney Function Tests; Menopaus | 1994 |
Association between serum uric acid and some cardiovascular risk factors in a Chinese population.
Topics: Adult; Aging; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Female; Hong Kong; Humans; Male | 1994 |
Effects of ageing on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Antioxidants; Ascorbic Acid; Brain Stem; Corpus Stri | 1993 |
The effect of age on concentrations of monoamines, amino acids, and their related substances in the cerebrospinal fluid.
Topics: Adult; Aged; Aging; Amino Acids; Biogenic Monoamines; Blood-Brain Barrier; Brain Chemistry; Chromato | 1993 |
Incorporation of [14C]hypoxanthine into cardiac adenine nucleotides: effect of aging and post-ischemic reperfusion.
Topics: Adenine Nucleotides; Aging; Animals; Hypoxanthine; Hypoxanthines; Male; Myocardial Ischemia; Myocard | 1993 |
Age-dependent differences of ATP breakdown and ATP-catabolite release in ischemic and reperfused hearts.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aging; Animals; Energy Metabolism; In Vitro Technique | 1993 |
The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years.
Topics: Aged; Aging; Blood Pressure; Blood Viscosity; Cross-Sectional Studies; Female; Fibrinogen; Hematocri | 1993 |
Mixed monosodium urate and calcium pyrophosphate crystal-induced arthropathy. A review of seventeen cases.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthrography; Calcium Pyrophosphate; Crystallization; Female; | 1996 |
Gout, uric acid, albumin, and aging.
Topics: Aging; Gout; Humans; Uric Acid | 1996 |
Age-related changes in the peroxyl radical scavenging capacity of human plasma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Antioxidants; Ascorbic Acid; Chromans; F | 1997 |
In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Antioxidants; Bilirubin; Catalase; Cells, Cult | 1997 |
Duodenal flow of microbial nitrogen estimated from urinary excretion of purine derivatives in calves after early weaning.
Topics: Aging; Allantoin; Animals; Body Weight; Cattle; Digestion; Duodenum; Eating; Male; Nitrogen; Purines | 1997 |
Social and biological predictors of early menopause: a model for premature aging.
Topics: Adult; Aging; Blood Glucose; Blood Pressure; Body Mass Index; Creatinine; Denmark; Female; Health St | 1997 |
Purine metabolism of uric acid urolithiasis induced in newborn piglets.
Topics: Aging; Allantoin; Animals; Animals, Newborn; Body Weight; Hypoxanthine; Purines; Swine; Swine Diseas | 1998 |
Serum selenium levels as indicators of body status in cancer patients and their relationship with other nutritional and biochemical markers.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers | 1998 |
Lung lining fluid antioxidants in male broilers: age-related changes under thermoneutral and cold temperature conditions.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Body Fluids; Chickens; Chromatography, High Pressure Li | 1998 |
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients.
Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Th | 1999 |
Age-related plasma chemistry findings in the buff-crested bustard (Eupodotis ruficrista gindiana).
Topics: Aging; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Birds; Blood Chemical Analysis; B | 1998 |
Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats.
Topics: Aging; Angiotensin II; Animals; Antioxidants; Ascorbic Acid; Biflavonoids; Blood Glucose; Body Weigh | 1999 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 En | 1998 |
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?
Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Enzyme | 1999 |
Cancer mortality trends in two cohorts of elderly people having different life-styles.
Topics: Age Distribution; Aged; Aging; Alanine Transaminase; Alkaline Phosphatase; Body Mass Index; Cohort S | 1999 |
Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study.
Topics: Age Distribution; Aging; Boston; Cardiovascular Diseases; Cause of Death; Female; Follow-Up Studies; | 1999 |
Serum urate is associated with baseline renal dysfunction but not survival or deterioration in renal function in malignant phase hypertension.
Topics: Aged; Aging; Blood Pressure; Cause of Death; Creatinine; Female; Follow-Up Studies; Humans; Hyperten | 2000 |
Age-related change in relationship between body-mass index, serum sialic acid, and atherogenic risk factors.
Topics: Adult; Aging; Arteriosclerosis; Biomarkers; Blood Pressure; Body Mass Index; Cholesterol; Cholestero | 1998 |
Plasma antioxidants and longevity: a study on healthy centenarians.
Topics: Aged; Aged, 80 and over; Aging; Antioxidants; Ascorbic Acid; Carotenoids; Erythrocytes; Female; Glut | 2000 |
Hematology and serum chemistries of nestling bald eagles (Haliaeetus leucocephalus) in the lower peninsula of MI, USA.
Topics: Aging; Alkaline Phosphatase; Blood Proteins; Blood Urea Nitrogen; Cholesterol; Eagles; Environmental | 2000 |
Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed to manganese.
Topics: Aging; Animals; Brain Stem; Corpus Striatum; Energy Metabolism; Glutamic Acid; Hypoxanthine; Male; M | 2000 |
Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats.
Topics: Aging; Animals; Antimetabolites; Ascorbic Acid; Brain; Buthionine Sulfoximine; Dehydroascorbic Acid; | 2000 |
Dehydroascorbic acid and oxidative stress in haemodialysis patients.
Topics: Aging; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Case-Control Studies; | 2001 |
Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol.
Topics: Aging; Allopurinol; Animals; Antimetabolites; Arginine; Blood Glucose; Body Weight; Chickens; Cross- | 2001 |
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
Topics: Aging; Animals; Ascorbic Acid; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Respons | 2001 |
Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects.
Topics: Adult; Aged; Aging; Cohort Studies; Creatinine; Female; Humans; Male; Mass Screening; Middle Aged; R | 2001 |
Is serum uric acid level associated with all-cause mortality in high-functioning older persons: MacArthur studies of successful aging?
Topics: Aged; Aging; Cardiovascular Diseases; Cause of Death; Cohort Studies; Female; Humans; Life Style; Ma | 2001 |
Development of a biochemical profile for mass-reared boll weevils (Coleoptera: Curculionidae).
Topics: Aging; Animals; Cholesterol; Coleoptera; Female; Lipid Metabolism; Male; Proteins; Sex Factors; Uric | 1976 |
Changes in the acid-soluble nucleotide composition of red cells of cattle at various ages.
Topics: Adenine Nucleotides; Aging; Animals; Cattle; Erythrocytes; Female; Guanosine Triphosphate; NAD; NADP | 1976 |
Transport ontogeny and selective substrate stimulation as models for identification of multiple renal organic anion transport systems.
Topics: 4-Aminobenzoic Acid; Aging; Animals; Animals, Newborn; Anions; Aspirin; Biological Transport, Active | 1977 |
Peritoneal dialysis is reinstated.
Topics: Aged; Aging; Blood Urea Nitrogen; Catheters, Indwelling; Child; Child, Preschool; Chronic Disease; C | 1978 |
[Distribution and correlations of serum uric-acid in two French adult populations : 13,885 men and 6,861 women (author's transl)].
Topics: Adult; Aged; Aging; Blood Pressure; Body Weight; Cholesterol; Creatinine; Female; Humans; Male; Midd | 1978 |
Age-dependent changes in blood monocyte populations in man.
Topics: Adolescent; Adult; Aged; Aging; Child; Female; Humans; Leukocyte Count; Male; Middle Aged; Monocytes | 1979 |
Caffeine metabolism in the newborn.
Topics: Adult; Aging; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Humans; Infant; Inf | 1979 |
[Metabolic studies in the longitudinal study of the Gerontological Research Project].
Topics: Adult; Aged; Aging; Cholesterol; Fatty Acids; Female; Germany, East; Humans; Longitudinal Studies; M | 1978 |
Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies.
Topics: Adult; Aged; Aging; Calculi; Follow-Up Studies; Glomerular Filtration Rate; Gout; Humans; Inulin; Ki | 1975 |
The effect of age on the inflammatory response to arthritis-associated crystals.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Arthritis; Cell Death; Child; Crystallization; Durapati | 1992 |
Human liver xanthine oxidase: nature and extent of individual variation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Child; Female; Humans; Hydroge | 1991 |
Uric acid content of Drosophila decreases with aging.
Topics: Aging; Animals; Drosophila melanogaster; Male; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1991 |
The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase.
Topics: Adenosine Triphosphate; Adult; Aging; Body Mass Index; Creatinine; Exercise; Female; Humans; Hypoxan | 1991 |
Does xanthine oxidase cause damage during myocardial ischemia?
Topics: Aging; Animals; Cattle; Coronary Disease; Guinea Pigs; Humans; In Vitro Techniques; Mice; Myocardium | 1991 |
Uric acid levels in southern Germany in 1989. A comparison with studies from 1962, 1971, and 1984.
Topics: Adult; Aged; Aging; Female; Germany; Gout; Humans; Kidney Calculi; Male; Middle Aged; Population Sur | 1990 |
Effects of uric acid and caffeine on A1 adenosine receptor binding in developing rat brain.
Topics: Adenosine; Aging; Animals; Binding, Competitive; Brain; Caffeine; Male; Oxonic Acid; Rats; Rats, Inb | 1990 |
Arterial disease risk factors and angiographic evidence of atheroma of the carotid artery.
Topics: Aging; Angiography, Digital Subtraction; Arteriosclerosis; Carotid Artery Diseases; Cerebrovascular | 1989 |
Increased uric acid in the developing brain and spinal cord following cytomegalovirus infection.
Topics: Aging; Animals; Brain; Cytomegalovirus Infections; Mice; Mice, Inbred BALB C; Organ Specificity; Ref | 1989 |
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients.
Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; T | 1989 |
Studies on normal and abnormal excretion patterns of uric acid in Bahawalpur.
Topics: Adolescent; Adult; Aged; Aging; Female; Gout; Humans; Male; Middle Aged; Pakistan; Urban Population; | 1987 |
Theophylline pharmacokinetics in normal elderly subjects.
Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theo | 1988 |
Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Free Radicals; Glutathione; Male; Organ Size; Rats; Tis | 1988 |
Distribution of aromatic and fluorescent compounds within single human lenses.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Fluorescence; | 1987 |
Prevalence of rheumatoid arthritis, osteoarthritis, chondrocalcinosis and gouty arthritis at age 79.
Topics: Aged; Aging; Arthritis; Arthritis, Rheumatoid; Chondrocalcinosis; Female; Finger Joint; Gout; Hip Jo | 1986 |
Body weight and coronary disease risk: patterns of risk factor change associated with long-term weight change. The Normative Aging Study.
Topics: Adult; Aged; Aging; Blood Glucose; Blood Pressure; Body Weight; Coronary Disease; Humans; Longitudin | 1986 |
[The effects of physiologic alterations, disease states and drugs on serum uric acid levels in an elderly population].
Topics: Aged; Aged, 80 and over; Aging; Diuretics; Female; Humans; Male; Middle Aged; Uric Acid | 1986 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M | 1987 |
Relationships between red cell cation contents and blood pressure level.
Topics: Adult; Aging; Blood Glucose; Blood Pressure; Erythrocytes; Hematocrit; Humans; Hypertension; Middle | 1985 |
The liver is an organ site for the release of inosine metabolized by non-glycolytic pig red cells.
Topics: Adenosine Triphosphate; Aging; Animals; Energy Metabolism; Erythrocytes; Glycolysis; Hypoxanthine; H | 1985 |
Biological and social predictors of health in an aging cohort.
Topics: Aged; Aging; Alcohol Drinking; Anthropometry; Blood Glucose; Blood Pressure; Chronic Disease; Epidem | 1985 |
Objectives, organization, and results of the Leipzig longitudinal study.
Topics: Adult; Aging; Blood Pressure; Cholesterol; Fatty Acids; Female; Germany, East; Humans; Longitudinal | 1985 |
The severity of infection stones compared to other stones in the upper urinary tract.
Topics: Adolescent; Adult; Aged; Aging; Calcium; Cystine; Female; Humans; Kidney Calculi; Male; Middle Aged; | 1985 |
Problems of interpretation of laboratory findings in the old.
Topics: Aged; Aging; Anemia, Hypochromic; Blood Glucose; Blood Sedimentation; Calcium; Cholesterol; Clinical | 1973 |
Development of renal gluconeogenesis in chicks fed high fat and high protein "carbohydrate-free" diets.
Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Chick Embryo; Chickens; D | 1973 |
[Clinico-chemical findings in 41 centenarians compared to younger stages of life].
Topics: Adult; Age Factors; Aged; Aging; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood | 1973 |
[Changes of clearance values in the aged].
Topics: Aged; Aging; Aminohippuric Acids; Blood Urea Nitrogen; Creatinine; Female; Humans; Inulin; Kidney Fu | 1973 |
[Normal values of plasma uric acid in South Germany. Comparison with determinations made ten years ago (author's transl)].
Topics: ABO Blood-Group System; Adolescent; Adult; Aging; Blood Donors; Body Weight; Diet; Dietary Proteins; | 1973 |
Age dependency of mean values in blood and blood serum of healthy Dutch school children between 4 and 13 years of age.
Topics: Adolescent; Aging; Blood; Blood Proteins; Body Height; Body Surface Area; Body Weight; Calcium; Chil | 1973 |
Retrospective study of men who had undergone myocardial infarction at the age of 40 years or younger.
Topics: Adult; Age Factors; Aged; Aging; Angina Pectoris; Arteriosclerosis; Blood Glucose; Blood Pressure; C | 1974 |
Uric acid excretion in infancy.
Topics: Aging; Birth Weight; Body Weight; Child; Child, Preschool; Female; Humans; Hydrogen-Ion Concentratio | 1974 |
Effect of allopurinol on the accumulation of xanthine dehydrogenase in liver and pancreas of chickens after hatching.
Topics: Aging; Allopurinol; Amino Acids; Ammonium Sulfate; Animals; Carbon Isotopes; Chemical Precipitation; | 1972 |
A filter paper sampling method for the uric acid:creatinine ratio in urine. Normal values in the the newborn.
Topics: Aging; Creatinine; Female; Filtration; Humans; Infant, Newborn; Male; Mass Screening; Methods; Paper | 1972 |
[Changes in blood chemical components in the aged].
Topics: Aged; Aging; Blood Proteins; Blood Urea Nitrogen; Cholesterol; Female; Humans; Male; Middle Aged; Ur | 1971 |
Biochemical normals in Nigerians with particular reference to electrolytes and urea.
Topics: Adolescent; Adult; Aging; Bicarbonates; Calcium; Child; Child, Preschool; Electrolytes; Female; Huma | 1970 |
The total nitrogen, protein, amino acid and uric acid ntent of ageing Drosophila.
Topics: Aging; Amino Acids; Animals; Body Weight; Drosophila; Indicators and Reagents; Male; Nitrogen; Prote | 1970 |
[Comparison between blood uric acid values in normal aged patients and in hypertensive, obese or diabetic subjects].
Topics: Aged; Aging; Diabetes Mellitus; Female; Humans; Hypertension; Male; Obesity; Uric Acid | 1967 |
[Changes in blood uric acid induced by diuretic treatment in aged subjects].
Topics: Aged; Aging; Diuretics; Humans; Uric Acid | 1967 |
[Cholesterol and uric acid in relation to age, sex and body weight. Statistical findings on 5000 normal and arteriosclerotic subjects (from the cases of the Clinica Medica and the Ambulatorio in the Istituto de Gerontologia of Florence)].
Topics: Adult; Aged; Aging; Arteriosclerosis; Body Weight; Cholesterol; Female; Humans; In Vitro Techniques; | 1965 |
[Uricemia in the senile age].
Topics: Aged; Aging; Female; Gout; Humans; Male; Uric Acid | 1966 |