Compounds > uric acid
Page last updated: 2024-10-20

uric acid and Aging

uric acid has been researched along with Aging in 236 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Serum uric acid (sUA) level may be associated with cognitive impairment/dementia."8.93Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis. ( Dawson, J; Fan, Y; Hewitt, J; Khan, AA; Quinn, TJ, 2016)
"Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension."7.91Age-differential association between serum uric acid and incident hypertension. ( Ahn, SV; Kim, HC; Lee, HY; Lee, SW; Nam, C; Oh, YA; Suh, I, 2019)
"Serum uric acid (UA), which has both antioxidant and pro-oxidant properties, is thought to be involved in cellular aging processes."7.91Negative Association of Serum URIC Acid with Peripheral Blood Cellular Aging Markers. ( He, S; Li, P; Li, W; Li, Y; Liu, H; Liu, Y; Lv, L; Ma, C; Ma, M; Ping, F; Sun, Q; Xu, L; Yu, J; Zhang, H, 2019)
"In patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective."7.88Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study. ( Bardin, T; Debette, S; Latourte, A; Perez-Ruiz, F; Richette, P; Soumaré, A, 2018)
"Although it is known that high uric acid (UA) level is associated with type 2 diabetes (T2DM) and metabolic syndrome (MetS), most of the previous studies were focused on adults."7.85The Role of Uric Acid for Predicting Future Metabolic Syndrome and Type 2 Diabetes in Older People. ( Chang, JB; Chen, YL; Hsieh, CH; Hung, YJ; Lee, CH; Liang, YJ; Lin, CM; Lin, JD; Pei, D; Wu, CZ, 2017)
"Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels."7.85Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause. ( Myint, KZ; Ohta, H; Yoshikata, R, 2017)
"Although serum uric acid (sUA) is not a criterion for diagnosing metabolic syndrome (MetS), many studies have identified a positive association between sUA and MetS in patients of various ages and ethnicities."7.83The Power of Serum Uric Acid in Predicting Metabolic Syndrome Diminishes With Age in an Elderly Chinese Population. ( Chang, HW; Chen, JH; Chen, YL; Chuang, TJ; Hsieh, CH; Huang, CL; Li, PF; Liu, JS; Pei, D, 2016)
"Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated."7.83Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. ( Abe, M; Katoh, T; Kawamoto, R; Kohara, K; Kumagi, T; Ninomiya, D, 2016)
"Some observational studies have suggested that serum uric acid (SUA) levels are one of the determinants of the metabolic syndrome (MetS)."7.83Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition. ( Bae, JC; Baek, JH; Jee, JH; Jin, SM; Kim, JH; Lee, MK; Yu, TY, 2016)
"Several studies have documented an association between serum uric acid (SUA) concentration and cardiac hypertrophy in hypertensive patients; however, the association remains unclear in chronic kidney disease (CKD) patients."7.80Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease. ( Fukui, A; Ikeda, H; Kitazono, T; Nakayama, M; Oniki, H; Tsuchihashi, T; Tsuruya, K; Ura, Y; Yoshitomi, R, 2014)
"Here we quantified the uric acid (UA) levels in 11 tissues and plasma of C57BL/6 male mice to track its turnover during 3 to 30 months of aging."7.78Uric acid levels in tissues and plasma of mice during aging. ( Ishigami, A; Iwama, M; Kondo, Y; Maruyama, N; Shimokado, K, 2012)
" Associations between uric acid (UA), metabolic syndrome (MetS) and carotid IMT have been reported, but findings regarding the relationship have been inconsistent."7.78Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome. ( Abe, M; Kawamoto, R; Kusunoki, T; Onji, M; Takayama, S, 2012)
"The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men."7.77Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. ( Chang, Y; Cho, J; Guallar, E; Kim, SG; Ryu, S, 2011)
" We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults."7.75Serum uric acid and prehypertension among Chinese adults. ( Liang, J; Qi, L; Song, H; Xue, Y; Zhang, T; Zou, C, 2009)
"We examined the association between serum uric acid (SUA) level and the frequency, risk, and cost of gout flares among the elderly."7.75Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter? ( Cahill, KE; Krishnan, E; Mody, RR; Patel, PA; Tang, J; Wu, EQ; Yu, AP, 2009)
"Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension."7.73Uric acid and the development of hypertension: the normative aging study. ( Gaziano, M; Gumieniak, O; Litonjua, AA; Perlstein, TS; Sparrow, D; Vokonas, PS; Weiss, ST; Williams, GH, 2006)
" Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, plasma glucose, body weight and chemiluminescence monitored oxidative stress in broiler chickens."7.71Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. ( Iqbal, M; Klandorf, H; Rathore, DS; Shi, X; Van Dyke, K, 2001)
"Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease."7.69Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. ( Landsberg, L; Lee, J; Sparrow, D; Vokonas, PS; Weiss, ST, 1995)
"In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated."7.68The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991)
"Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age."7.68Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991)
"The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago."7.66Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981)
"Hyperuricemia is a recognized risk factor for cardiovascular diseases."6.80Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension. ( Chen, YM; Ho, CS; Liu, ZM; Woo, J, 2015)
"Hyperuricemia was present in 29% of men and 34% of women."5.91Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid. ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Laucevičius, A; Rinkūnienė, E; Ryliškytė, L, 2023)
"Allantoin is a nonenzymatic oxidative product of uric acid in human."5.32Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004)
"Uric acid is a powerful antioxidant and is a scavenger of singlet oxygen and radicals."5.26Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. ( Ames, BN; Cathcart, R; Hochstein, P; Schwiers, E, 1981)
"Although many studies have indicated a relationship between nonalcoholic fatty liver disease (NAFLD) and hyperuricemia, a few studies specifically examining the effects of the severity of liver fat content (LFC) on serum uric acid (SUA) and the presence of hyperuricemia because of the limitation of the examination methods for NAFLD."5.20Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study. ( Gao, X; Li, Q; Li, X; Lin, H; Liu, X; Ma, H; Pan, B; Wang, D; Wu, J; Xia, M; Zhao, N, 2015)
"Serum uric acid (sUA) level may be associated with cognitive impairment/dementia."4.93Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis. ( Dawson, J; Fan, Y; Hewitt, J; Khan, AA; Quinn, TJ, 2016)
"High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e."4.91The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015)
" Carotid-femoral pulse wave velocity (cfPWV), assessed using applanation tonometry, was evaluated as an early vascular aging parameter in patients with hyperuricemia and with normal serum uric acid (sUA) levels."4.31The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients. ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Kazėnaitė, E; Rinkūnienė, E; Rugienė, R; Ryliškytė, L, 2023)
" Hyperuricemia was defined using uric acid levels as > 420 μmol/L and > 350 μmol/L in NHANES for men and women, respectively; in the NILS-LSA, serum uric acid was repeatedly measured at baseline and follow-up surveys."4.31Mushroom consumption and hyperuricemia: results from the National Institute for Longevity Sciences-Longitudinal Study of Aging and the National Health and Nutrition Examination Survey (2007-2018). ( Ba, DM; Gao, X; Muscat, J; Nishita, Y; Otsuka, R; Qiu, T; Tange, C; Zhang, S, 2023)
"Serum uric acid (UA), which has both antioxidant and pro-oxidant properties, is thought to be involved in cellular aging processes."3.91Negative Association of Serum URIC Acid with Peripheral Blood Cellular Aging Markers. ( He, S; Li, P; Li, W; Li, Y; Liu, H; Liu, Y; Lv, L; Ma, C; Ma, M; Ping, F; Sun, Q; Xu, L; Yu, J; Zhang, H, 2019)
"Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension."3.91Age-differential association between serum uric acid and incident hypertension. ( Ahn, SV; Kim, HC; Lee, HY; Lee, SW; Nam, C; Oh, YA; Suh, I, 2019)
"In patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective."3.88Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study. ( Bardin, T; Debette, S; Latourte, A; Perez-Ruiz, F; Richette, P; Soumaré, A, 2018)
"It was shown the alterations in hydrogen sulfide (H(2)S) metabolism and the development of oxidative and nitrozative stress in cardiovascular system by aging."3.85[PYRIDOXAL-5-PHOSPHATE RESTORES HYDROGEN SULFIDE SYNTHES AND REDOX STATE OF HEART AND BLOOD VESSELS TISSUE IN OLD ANIMALS]. ( Budko, AY; Mys, LA; Sagach, VF; Strutynska, NA, 2017)
"Although it is known that high uric acid (UA) level is associated with type 2 diabetes (T2DM) and metabolic syndrome (MetS), most of the previous studies were focused on adults."3.85The Role of Uric Acid for Predicting Future Metabolic Syndrome and Type 2 Diabetes in Older People. ( Chang, JB; Chen, YL; Hsieh, CH; Hung, YJ; Lee, CH; Liang, YJ; Lin, CM; Lin, JD; Pei, D; Wu, CZ, 2017)
"Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels."3.85Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause. ( Myint, KZ; Ohta, H; Yoshikata, R, 2017)
"The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in endothelial function (EF) has been tested only in middle-aged subjects affected by specific diseases."3.85Uric acid and endothelial function in elderly community-dwelling subjects. ( Aloe, R; Ceda, GP; Cederholm, T; Ferrucci, L; Larsson, A; Lauretani, F; Lind, L; Maggio, M; Meschi, T; Ruggiero, C; Ticinesi, A, 2017)
"Some observational studies have suggested that serum uric acid (SUA) levels are one of the determinants of the metabolic syndrome (MetS)."3.83Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition. ( Bae, JC; Baek, JH; Jee, JH; Jin, SM; Kim, JH; Lee, MK; Yu, TY, 2016)
"Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated."3.83Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. ( Abe, M; Katoh, T; Kawamoto, R; Kohara, K; Kumagi, T; Ninomiya, D, 2016)
"Although serum uric acid (sUA) is not a criterion for diagnosing metabolic syndrome (MetS), many studies have identified a positive association between sUA and MetS in patients of various ages and ethnicities."3.83The Power of Serum Uric Acid in Predicting Metabolic Syndrome Diminishes With Age in an Elderly Chinese Population. ( Chang, HW; Chen, JH; Chen, YL; Chuang, TJ; Hsieh, CH; Huang, CL; Li, PF; Liu, JS; Pei, D, 2016)
"Several studies have documented an association between serum uric acid (SUA) concentration and cardiac hypertrophy in hypertensive patients; however, the association remains unclear in chronic kidney disease (CKD) patients."3.80Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease. ( Fukui, A; Ikeda, H; Kitazono, T; Nakayama, M; Oniki, H; Tsuchihashi, T; Tsuruya, K; Ura, Y; Yoshitomi, R, 2014)
" Associations between uric acid (UA), metabolic syndrome (MetS) and carotid IMT have been reported, but findings regarding the relationship have been inconsistent."3.78Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome. ( Abe, M; Kawamoto, R; Kusunoki, T; Onji, M; Takayama, S, 2012)
"The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men."3.77Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. ( Chang, Y; Cho, J; Guallar, E; Kim, SG; Ryu, S, 2011)
" DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities as well as the level of nonenzymatic antioxidants--urea and uric acids, because during organism aging the antioxidant defense systems are being suppressed."3.77[Mechanism of delta-sleep inducing peptide geroprotective activity]. ( Bondarenko, TI; Maĭboroda, EA; Mikhaleva, II; Prudchenko, IA, 2011)
"Epidemiological studies have shown that increased serum uric acid (SUA) level is associated with coronary artery disease (CAD)."3.75Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burden. ( Boyaci, B; Cemri, M; Cengel, A; Kocaman, SA; Sahinarslan, A; Timurkaynak, T, 2009)
" We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults."3.75Serum uric acid and prehypertension among Chinese adults. ( Liang, J; Qi, L; Song, H; Xue, Y; Zhang, T; Zou, C, 2009)
"We examined the association between serum uric acid (SUA) level and the frequency, risk, and cost of gout flares among the elderly."3.75Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter? ( Cahill, KE; Krishnan, E; Mody, RR; Patel, PA; Tang, J; Wu, EQ; Yu, AP, 2009)
"Sarcopenia may be related to increases in reactive oxygen species formation and inflammation, both of which are associated with elevations in serum uric acid."3.75Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III. ( Beavers, DP; Beavers, KM; Bowden, RG; Serra, MC; Wilson, RL, 2009)
" Since uric acid (UA), has strong antioxidant properties, we tested the hypothesis that UA levels is cross-sectionaly associated with muscle strength and protective against the decline of strength over the aging process."3.74Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons. ( Bandinelli, S; Cecchi, F; Ferrucci, L; Guarducci, L; Guralnik, JM; Lauretani, F; Macchi, C; Molino-Lova, R; Polcaro, P, 2008)
"Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension."3.73Uric acid and the development of hypertension: the normative aging study. ( Gaziano, M; Gumieniak, O; Litonjua, AA; Perlstein, TS; Sparrow, D; Vokonas, PS; Weiss, ST; Williams, GH, 2006)
" Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, plasma glucose, body weight and chemiluminescence monitored oxidative stress in broiler chickens."3.71Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. ( Iqbal, M; Klandorf, H; Rathore, DS; Shi, X; Van Dyke, K, 2001)
"Aging is a factor known to increase neuronal vulnerability to oxidative stress, which is widely accepted as a mechanism of manganese-induced neuronal damage."3.70Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats. ( Delogu, MR; Desole, MS; Esposito, G; Fresu, L; Miele, M; Migheli, R; Rocchitta, G; Serra, PA, 2000)
"Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease."3.69Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. ( Landsberg, L; Lee, J; Sparrow, D; Vokonas, PS; Weiss, ST, 1995)
"To determine the effect of aging on renal functions, I measured the concentration of blood urea nitrogen (BUN), serum uric acid and serum creatinine."3.69[The effects of aging on renal function test]. ( Yoshida, K, 1994)
"Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age."3.68Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991)
"In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated."3.68The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991)
" Abnormal angiograms were associated with greater age, treated hypertension, current smoking, and lower hemoglobin levels but with higher uric acid, factor VIII, and fibrinogen concentrations."3.67Arterial disease risk factors and angiographic evidence of atheroma of the carotid artery. ( Harrison, MJ; Hurst, C; Meade, TW; Schneidau, A; Wilkes, HC, 1989)
"The concentration of the free aromatic amino acids tryptophan and tyrosine, the antioxidant uric acid and some unidentified compounds have been determined in the water-soluble extracts of parts from clear and nuclear-cataractous human lenses."3.67Distribution of aromatic and fluorescent compounds within single human lenses. ( Bessems, GJ; Hoenders, HJ, 1987)
" From more than 30 variables examined in multivariate analyses, blood pressure, obesity, cigarette smoking, alcohol consumption, serum glucose, uric acid and triglyceride, were inversely associated with staying healthy while forced vital capacity and years spent in Japan were directly associated with health."3.67Biological and social predictors of health in an aging cohort. ( Benfante, R; Brody, J; Reed, D, 1985)
" With aging, there was a significant increase in plasma glucose, glutamic-oxalacetic transaminase (GOT), potassium, cholesterol, uric acid, and albumin."3.66Blood parameters of one-year-old and seven-year old partridges (Alectoris chukar). ( Mayeda, B; Vohra, P; Woodard, AE, 1983)
"Uric acid levels of adult male volunteers in a longitudinal study of human aging rose steadily between 1961 and 1978."3.66Trends in serum uric acid levels 1961--1980. ( Campion, EW; Glynn, RJ; Silbert, JE, 1983)
"The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago."3.66Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981)
"Forty-seven patients with gout, 28 of whom had not previously been treated with allopurinol, and 25 normal subjects, were examined for 24-h urinary excretion of the most important adrenal steroid derivatives."3.66Hormonal aspects of human gout--excretion of adrenal hormone derivatives in gouty patients. ( Aleo, MF; Bianchi, E; Ferrari, S; Gregolini, L; Marcolongo, R; Marinello, E, 1983)
" cholesterol, triglyceride, uric acid in serum; the number of erythrocytes and the components; obesity and blood pressure."3.66Serum high density lipoprotein cholesterol: as a cholesterol risk factor index for atherosclerotic diseases. ( Murata, K; Nakazawa, K, 1982)
"Hyperuricemia is a recognized risk factor for cardiovascular diseases."2.80Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension. ( Chen, YM; Ho, CS; Liu, ZM; Woo, J, 2015)
" Allopurinol is the most commonly used ULT, but there is no consensus on dosing in renal impairment."2.47The challenges of gout management in the elderly. ( Jordan, S; Stamp, LK, 2011)
"Hyperuricemia was present in 29% of men and 34% of women."1.91Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid. ( Badarienė, J; Čypienė, A; Gimžauskaitė, S; Jasiūnas, E; Laucevičius, A; Rinkūnienė, E; Ryliškytė, L, 2023)
"Metabolic syndrome was considered a proxy for overall cardiometabolic risk."1.48Association between serum activin A and metabolic syndrome in older adults: Potential of activin A as a biomarker of cardiometabolic disease. ( Chen, LK; Chou, MY; Kojima, T; Lee, WJ; Liang, CK; Lin, MH; Loh, CH; Peng, LN, 2018)
"Uric acid also plays important roles in primates but causes gout when present in excess in humans."1.46Uric acid, an important antioxidant contributing to survival in termites. ( Iuchi, Y; Matsuura, K; Nitao, M; Sakurai, H; Tasaki, E, 2017)
"Uric acid has been associated as a risk factor for cardiovascular disease."1.42Lower uric Acid linked with cognitive dysfunction in the elderly. ( Arias-Carrión, O; Barraza-Salas, M; Cisneros-Martínez, J; Méndez-Hernández, E; Ruano-Calderón, L; Salas-Pacheco, J; Téllez-Valencia, A, 2015)
"Hyperuricemia was defined as serum uric acid (SUA) >420 μmol/L for men, >360 μmol/L for women."1.37Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese. ( Lou, S; Meng, Z; Ren, X; Zhang, Q, 2011)
"Endotracheal infection, septicaemia, and gestational age, rather than antioxidant concentrations, are the most powerful predictors of the development of BPD."1.32Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies. ( Collard, KJ; Godeck, S; Holley, JE; Quinn, MW, 2004)
"Allantoin is a nonenzymatic oxidative product of uric acid in human."1.32Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004)
"Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss."1.31Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. ( Brundin, P; Castilho, RF; DiFiglia, M; Hansson, O; Petersén, A; Przedborski, S; Puschban, Z; Rice, M; Romero, N; Sapp, E; Sulzer, D, 2001)
"We analyzed cancer mortality trends in 3282 elderly subjects from two general Italian populations with different life-style patterns taking part in the Cardiovascular Study in the Elderly (CASTEL)."1.30Cancer mortality trends in two cohorts of elderly people having different life-styles. ( Biasin, R; Casiglia, E; Mazza, A; Pessina, AC; Pizziol, A; Privato, G; Scarpa, R; Sica, E, 1999)
"Uric acid is a powerful antioxidant and is a scavenger of singlet oxygen and radicals."1.26Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. ( Ames, BN; Cathcart, R; Hochstein, P; Schwiers, E, 1981)

Research

Studies (236)

TimeframeStudies, this research(%)All Research%
pre-199085 (36.02)18.7374
1990's39 (16.53)18.2507
2000's43 (18.22)29.6817
2010's61 (25.85)24.3611
2020's8 (3.39)2.80

Authors

AuthorsStudies
Čypienė, A2
Gimžauskaitė, S2
Rinkūnienė, E2
Jasiūnas, E2
Rugienė, R1
Kazėnaitė, E1
Ryliškytė, L2
Badarienė, J2
Laucevičius, A1
Ba, DM1
Zhang, S1
Nishita, Y1
Tange, C1
Qiu, T1
Gao, X2
Muscat, J1
Otsuka, R1
García, GO1
Paterlini, CA1
Hernandez, MM1
Behotas, RT1
Favero, M1
Seco Pon, JP1
Liu, J1
Yang, W1
Li, Y4
Wei, Z1
Dan, X1
Alves, PC1
Santos, N1
Guo, SM1
Liu, YT1
He, SR1
Wu, MS1
Tseng, WT1
Wu, RC1
Wu, IC1
Li, L1
Luo, J1
Jiang, Y1
Zhao, Z1
Chen, Y2
Huang, Q1
Zhang, L1
Wu, T1
Pang, J1
Ya, Z1
Fei, L1
Yue, Z1
Dan, L1
Neng-Bo, L1
Yi, L1
Ying, M1
Qin, W1
López, J1
Waters, M1
Routh, A1
Rakotonanahary, TF1
Woolaver, L1
Thomasson, A1
Holmes, E1
Steinmetz, HW1
Tasaki, E1
Sakurai, H1
Nitao, M1
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Wang, D1
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Kawamoto, R2
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Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Bogalusa Heart Study[NCT00005129]11,737 participants (Actual)Observational1972-06-30Active, not recruiting
Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept[NCT04012294]Phase 3200 participants (Anticipated)Interventional2019-08-30Recruiting
A Double-blind Randomized Controlled Trial on Whole Soy and Daidzein Supplementation on Reduction of Blood Pressure in Prehypertensive Postmenopausal Chinese Women[NCT01270737]270 participants (Anticipated)Interventional2011-03-31Not yet recruiting
The Effects of Soy Protein and/or Isoflavones on Glycemic Control, Insulin Sensitivity and Cardiovascular Risk Factors-a Six Months RCT Among Postmenopausal Women[NCT00856882]0 participants Interventional2007-10-31Completed
[NCT00005128]0 participants Observational1972-07-31Completed
[NCT00005282]0 participants Observational1981-12-31Completed
Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism[NCT01990560]Phase 48 participants (Actual)Interventional2013-11-30Completed
Study Protocol for a Prospective Observational Study Investigating the Role of Luminal Pressure on Arteriovenous Fistula Maturation[NCT04017806]60 participants (Anticipated)Observational2018-09-19Recruiting
Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care[NCT05698680]Phase 4314 participants (Anticipated)Interventional2023-01-18Recruiting
[NCT00005123]0 participants Observational1965-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

A1C Level

Change in hyperglycemia assessed by HbA1c, also known as glycated hemoglobin (NCT01990560)
Timeframe: Baseline, 3 months, and 6 months

Interventionpercentage of red blood cells (Mean)
Baseline3 months6 months
Mifepristone6.26.13756.125

Body Mass Index (BMI)

Change in metabolic syndrome as assessed by BMI (NCT01990560)
Timeframe: Baseline and 6 months

Interventionkg/m2 (Mean)
Baseline6 months
Mifepristone35.153834.5463

CushingQoL

Change in Quality of Life - as assessed by the Cushing's Quality of Life questionnaire (CushingQoL). Patient completed questionnaire, 12 items, each scored on a 5 point score, resulting in a score of 12 (worst) to 60 (best) where higher scores indicate more favorable QOL. (NCT01990560)
Timeframe: Baseline and 6 months

Interventionunits on a scale (Mean)
Baseline6 months
Mifepristone37.285738.7857

Fasting Lipid Profile

Change in metabolic syndrome as assessed by fasting lipid profile which includes Low-density lipoproteins ( LDL), High-density lipoproteins (HDL), and Triglycerides (Trigs) levels, and total cholesterol which is the sum of HDL plus LDL and 20% of trigs. (NCT01990560)
Timeframe: Baseline and 6 months

Interventionmg/dL (Mean)
Total Cholesterol BaselineTotal Cholesterol 6 monthsLDL baselineLDL 6 monthsHDL BaselineHDL 6 monthsTrigs BaselineTrigs 6 months
Mifepristone178.63171.4397.88104.3759.1346.86107.88100.29

HOMA-IR

Change in hyperglycemia assessed by Homeostatic Model Assessment of Insulin Resistance, HOMA-IR (a validated assessment of insulin resistance). HOMA-IR = fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5. (NCT01990560)
Timeframe: Baseline and 6 months

InterventionHOMA-IR score (Mean)
Baseline6 months
Mifepristone2.4181.465

Hospital Anxiety and Depression Scale (HADS)

Change in Quality of Life as assessed by the Hospital Anxiety and Depression Scale (HADS). Questionnaire with 7 items for anxiety and 7 items for depression, each item is scored on a 4 point response 0 - 3, with full range from 0 to 42, with higher score indicating more severe anxiety or depression (NCT01990560)
Timeframe: Baseline and 6 months

Interventionunits on a scale (Mean)
Baseline6 months
Mifepristone16.285711.1667

Nottingham Health Profile (NHP)

Change in Quality of Life as assessed by the Nottingham Health Profile (NHP) which is a patient reported questionnaire to measure a patient's view of their own health status. There are 6 sections (Energy level, Pain, Emotional Reaction, Sleep, Social Isolation, and Physical Abilities. All questions have only yes/no answer options and each section score is weighted so that the possible score range for any section is 0-100. The higher the score, the greater the number and severity of problems. (NCT01990560)
Timeframe: Baseline and 6 months

Interventionunits on a scale (Mean)
Energy Level (EL) BaselineEL 6 monthsPain (P) BaselineP 6 monthsEmotional Reaction (ER) BaselineER 6 monthsSleep (S) BaselineS 6 monthsSocial Isolation (SI) BaselineSI 6 monthsPhysical Abilities (PA) BaselinePA 6 months
Mifepristone32.6045.4024.8832.0827.0335.0924.8731.1520.0931.1523.0627.49

Quality of Life

Change in Quality of Life as assessed by the Beck Depression Inventory. a 21-question multiple choice, self-report inventory that is used for measuring the severity of anxiety. Scoring is from a 0 (not at all) to 3 (severe) with a total score range of 0-63. Higher total scores indicate more severe anxiety symptoms. (NCT01990560)
Timeframe: Baseline and 6 months

Interventionunits on a scale (Mean)
Baseline6 months
Mifepristone16.142911.7143

State Trait Anxiety Inventory (STAI)

Change in Quality of Life - as assessed by the State Trait Anxiety Inventory (STAI). The State-Trait Anxiety Inventory both state and trait anxiety separately. Each type of anxiety has its own scale of 20 different questions that are scored and averaged. Total scores range from 20 to 80, with higher scores correlating with greater anxiety. (NCT01990560)
Timeframe: Baseline and 6 months

Interventionunits on a scale (Mean)
Baseline6 months
Mifepristone25.428628.8571

Waist Circumference

Change in metabolic syndrome as assessed by waist circumference (NCT01990560)
Timeframe: Baseline and 6 months

Interventioncm (Mean)
Baseline6 months
Mifepristone103.2599.3125

Weight

Change in metabolic syndrome as assessed by weight (NCT01990560)
Timeframe: Baseline and 6 months

Interventionkg (Mean)
Baseline6 months
Mifepristone99.5797.75

Reviews

14 reviews available for uric acid and Aging

ArticleYear
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
    Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21

    Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom

2015
Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis.
    Age (Dordrecht, Netherlands), 2016, Volume: 38, Issue:1

    Topics: Aging; Cognition; Cognitive Dysfunction; Dementia; Disease Progression; Humans; Neuropsychological T

2016
The challenges of gout management in the elderly.
    Drugs & aging, 2011, Aug-01, Volume: 28, Issue:8

    Topics: Aged; Aging; Gout; Humans; Uric Acid

2011
Clinical oxidation parameters of aging.
    Free radical research, 2006, Volume: 40, Issue:12

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Aldehydes; Amino Acids, Branched-Chain; Antioxidants; Ascorbic A

2006
The detection of environmental mutagens and potential carcinogens.
    Cancer, 1984, May-15, Volume: 53, Issue:10

    Topics: Aging; Animals; Biological Assay; Biotransformation; Carcinogens, Environmental; DNA; DNA Repair; Fe

1984
Evolution of antioxidant defence mechanisms.
    European journal of nutrition, 2000, Volume: 39, Issue:2

    Topics: Adaptation, Biological; Aging; Antioxidants; Ascorbic Acid; Atmosphere; Biological Evolution; Chroni

2000
The antioxidant network of the stratum corneum.
    Current problems in dermatology, 2001, Volume: 29

    Topics: Aging; Air Pollutants; Animals; Antioxidants; Arm; Ascorbic Acid; Benzoyl Peroxide; Catalase; Cheek;

2001
New knowledge of the pathogenesis of gout.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1978, Volume: 12

    Topics: Aging; Complement System Proteins; Crystallization; Endotoxins; Factor XII; Gout; Humans; Hydrogen-I

1978
The elderly patient. A special case for diuretic therapy.
    Drugs, 1986, Volume: 31 Suppl 4

    Topics: Aged; Aging; Cerebrovascular Disorders; Diuretics; Heart Failure; Humans; Hyperglycemia; Hyperlipide

1986
[Current aspects of the etiology and pathogenesis of primary gout].
    Vutreshni bolesti, 1985, Volume: 24, Issue:2

    Topics: Adult; Aging; Anaerobiosis; Female; Glycolysis; Gout; Humans; Kidney; Lysosomes; Male; Nutritional P

1985
Antioxidants and longevity of mammalian species.
    Basic life sciences, 1985, Volume: 35

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Body Temperature; Brain; Carotenoids; Catalase; Cerulop

1985
Renal excretion of drugs: tubular transport and metabolism.
    Annual review of pharmacology, 1972, Volume: 12

    Topics: Aging; Aminohippuric Acids; Animals; Biogenic Amines; Biological Transport, Active; Catechols; Cell

1972
Precursors and prevention of coronary artery disease. An overview.
    Modern treatment, 1972, Volume: 9, Issue:2

    Topics: Aging; Coronary Disease; Diabetes Complications; Diet; Female; Humans; Hypercholesterolemia; Hyperli

1972
The potential toxicity of excessive polyunsaturates. Do not let the patient harm himself.
    American heart journal, 1973, Volume: 85, Issue:6

    Topics: Adult; Aging; Coronary Disease; Dietary Fats; Fatty Acids, Unsaturated; Humans; Male; Skin Diseases;

1973

Trials

7 trials available for uric acid and Aging

ArticleYear
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Aged; Aging; Cardiovascular Diseases; China; Dietary Supplements; Double-Blind Method; Female; Human

2015
Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adipose Tissue; Aged; Aging; China; Female; Humans; Hyperuricemia; Liver; Male; Middle Aged; Non-alc

2015
Postnatal changes in plasma chain-breaking antioxidants in healthy preterm infants fed formula and/or human milk.
    The American journal of clinical nutrition, 1994, Volume: 60, Issue:6

    Topics: Aging; Antioxidants; Ascorbic Acid; Bilirubin; Humans; Infant Food; Infant, Newborn; Infant, Prematu

1994
Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 2

    Topics: Adult; Aged; Aging; Ascorbic Acid; Exercise; Fatty Acids; Humans; Male; Malondialdehyde; Middle Aged

1993
Urinary excretion of minerals, oxalate, and uric acid in north Indian children.
    Pediatric nephrology (Berlin, Germany), 1997, Volume: 11, Issue:2

    Topics: Adolescent; Aging; Body Height; Body Mass Index; Body Weight; Calcium; Child; Creatinine; Female; Hu

1997
Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:11

    Topics: Absorptiometry, Photon; Adipose Tissue; Adrenal Gland Neoplasms; Adult; Aging; Blood Pressure; Body

2001
Antihypertensive therapy in patients above age 60 years (Fourth Interim report of the European Working Party on High Blood pressure in Elderly: EWPHE).
    Clinical science and molecular medicine. Supplement, 1978, Volume: 4

    Topics: Aged; Aging; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Doubl

1978

Other Studies

215 other studies available for uric acid and Aging

ArticleYear
The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients.
    Nutrients, 2023, Jan-31, Volume: 15, Issue:3

    Topics: Aging; Blood Pressure; Drinking; Female; Humans; Hyperuricemia; Lithuania; Male; Middle Aged; Pulse

2023
Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid.
    Nutrients, 2023, Jul-27, Volume: 15, Issue:15

    Topics: Aging; Alcohol Drinking; Female; Habits; Humans; Hyperuricemia; Male; Metabolic Syndrome; Middle Age

2023
Mushroom consumption and hyperuricemia: results from the National Institute for Longevity Sciences-Longitudinal Study of Aging and the National Health and Nutrition Examination Survey (2007-2018).
    Nutrition journal, 2023, Nov-22, Volume: 22, Issue:1

    Topics: Adult; Agaricales; Aged; Aging; Female; Humans; Hyperuricemia; Longevity; Longitudinal Studies; Male

2023
HEMATOLOGY AND PLASMA CHEMISTRY VALUES IN BEACHED MAGELLANIC PENGUIN (
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2020, Jan-09, Volume: 50, Issue:4

    Topics: Aging; Alkaline Phosphatase; Animals; Animals, Wild; Antibodies, Heterophile; Argentina; Blood Gluco

2020
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.
    BMC medical genetics, 2020, 03-17, Volume: 21, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cardiovascu

2020
Sex and Age-Specific Hematology and Biochemistry Reference Intervals of Live Iberian Hares (Lepus granatensis) and Comparison with Postmortem Sampling.
    Journal of wildlife diseases, 2021, 01-06, Volume: 57, Issue:1

    Topics: Aging; Animals; Blood Glucose; Blood Proteins; Calcium; Chlorides; Cholesterol; Erythrocyte Count; E

2021
Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study.
    Aging, 2021, 04-04, Volume: 13, Issue:7

    Topics: Aged; Aging; Biomarkers; Cause of Death; Cohort Studies; Female; Hand Strength; Humans; Male; Middle

2021
Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model
    Food & function, 2021, Sep-20, Volume: 12, Issue:18

    Topics: Aging; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Epithelial Cells; Female; Gal

2021
Association between serum gamma-glutamyl transferase and serum uric acid levels in Chinese females: A cross-sectional study.
    Endocrine research, 2017, Volume: 42, Issue:4

    Topics: Adult; Aged; Aging; Biomarkers; China; Cross-Sectional Studies; Female; gamma-Glutamyltransferase; H

2017
HEMATOLOGY AND PLASMA CHEMISTRY OF THE PLOUGHSHARE TORTOISE (ASTROCHELYS YNIPHORA) IN A CAPTIVE BREEDING PROGRAM.
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2017, Volume: 48, Issue:1

    Topics: Aging; Animal Husbandry; Animals; Blood Cell Count; Breeding; Calcium; Endangered Species; Female; M

2017
Uric acid, an important antioxidant contributing to survival in termites.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Aging; Animals; Antioxidants; Female; Free Radical Scavengers; Humans; Isoptera; Lipid Peroxidation;

2017
Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study.
    Annals of the rheumatic diseases, 2018, Volume: 77, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Brain; Cohort Studies; Dementia; Female; Follow-Up Studi

2018
Neonatal rat age, sex and strain modify acute antioxidant response to ozone.
    Inhalation toxicology, 2017, Volume: 29, Issue:7

    Topics: Aging; Air Pollutants; Animals; Animals, Newborn; Ascorbic Acid; Body Weight; Female; Glutathione; L

2017
BIOCHEMISTRY PANEL REFERENCE INTERVALS FOR JUVENILE GOLDFISH (CARASSIUS AURATUS).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2017, Volume: 48, Issue:3

    Topics: Aging; Animals; Aspartate Aminotransferases; Blood Glucose; Calcium; Creatine Kinase; Goldfish; Hema

2017
Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Attention; Brain; Cohort Studies; Executive Function; Female;

2017
Longitudinal Associations of Metabolic Syndrome Severity Between Childhood and Young Adulthood: The Bogalusa Heart Study.
    Metabolic syndrome and related disorders, 2018, Volume: 16, Issue:5

    Topics: Adolescent; Adult; Aging; Alabama; Black People; Cardiovascular Diseases; Child; Cross-Sectional Stu

2018
Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study.
    Scientific reports, 2018, 03-27, Volume: 8, Issue:1

    Topics: Age Factors; Aged; Aging; Body Mass Index; Cardiovascular Diseases; Carotid Intima-Media Thickness;

2018
Blood Chemistry Reference Values for Free-Ranging Asiatic Black Bears ( Ursus thibetanus) by Season, Age, and Sex.
    Journal of wildlife diseases, 2018, Volume: 54, Issue:3

    Topics: Aging; Ammonia; Animals; Bilirubin; Blood Glucose; Blood Urea Nitrogen; Cholesterol; Creatine; Femal

2018
[PYRIDOXAL-5-PHOSPHATE RESTORES HYDROGEN SULFIDE SYNTHES AND REDOX STATE OF HEART AND BLOOD VESSELS TISSUE IN OLD ANIMALS].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2017, Volume: 63, Issue:1

    Topics: Aging; Animals; Aorta; Cardiotonic Agents; Hydrogen Sulfide; Hydroxyl Radical; Leukotriene C4; Male;

2017
Association between serum activin A and metabolic syndrome in older adults: Potential of activin A as a biomarker of cardiometabolic disease.
    Experimental gerontology, 2018, 10-01, Volume: 111

    Topics: Absorptiometry, Photon; Activins; Aged; Aged, 80 and over; Aging; Biomarkers; Body Mass Index; C-Rea

2018
Age-differential association between serum uric acid and incident hypertension.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2019, Volume: 42, Issue:3

    Topics: Adult; Age Factors; Aged; Aging; Antihypertensive Agents; Asian People; Blood Pressure; Body Mass In

2019
High Serum Uric Acid is Highly Associated with a Reduced Left Ventricular Ejection Fraction Rather than Increased Plasma B-type Natriuretic Peptide in Patients with Cardiovascular Diseases.
    Scientific reports, 2019, 01-24, Volume: 9, Issue:1

    Topics: Aged; Aging; Biomarkers; Cardiac Catheterization; Cardiovascular Diseases; Female; Humans; Male; Mid

2019
Serum Biochemical Analytes and Trace Elements in Juvenile Whooping Cranes (
    Journal of wildlife diseases, 2019, Volume: 55, Issue:4

    Topics: Acid-Base Equilibrium; Aging; Alkaline Phosphatase; Animals; Animals, Wild; Aspartate Aminotransfera

2019
Negative Association of Serum URIC Acid with Peripheral Blood Cellular Aging Markers.
    The journal of nutrition, health & aging, 2019, Volume: 23, Issue:6

    Topics: Aging; Biomarkers; Cellular Senescence; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female;

2019
Association between serum uric acid and bone health in adolescents.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019, Volume: 30, Issue:10

    Topics: Absorptiometry, Photon; Adolescent; Aging; Anthropometry; Biomarkers; Body Mass Index; Bone Density;

2019
Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice.
    Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:8

    Topics: Aging; Animals; Male; Mice, Inbred ICR; Theophylline; Uric Acid

2019
Influence of ageing process on body composition of antioxidant and lipid peroxidation among healthy individuals in South West Nigeria.
    The Nigerian postgraduate medical journal, 2013, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; alpha-Tocopherol; Antioxidants; Asco

2013
Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2014, Volume: 37, Issue:3

    Topics: Adult; Aged; Aging; Cardiomegaly; Cross-Sectional Studies; Disease Progression; Echocardiography; Fe

2014
Association between serum uric acid and lumbar spine bone mineral density in peri- and postmenopausal Japanese women.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014, Volume: 25, Issue:3

    Topics: Aged; Aging; Bone Density; Female; Humans; Lumbar Vertebrae; Menopause; Middle Aged; Osteoporosis, P

2014
Serum uric acid: relationships with biomarkers in adolescents and changes over 1 year.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Adolescent; Aging; Anthropometry; Biomarkers; Body Weight; Female; Heart Diseases; Humans; Longitudi

2014
Aging, not menopause, is associated with higher prevalence of hyperuricemia among older women.
    Menopause (New York, N.Y.), 2014, Volume: 21, Issue:11

    Topics: Adult; Aged; Aging; Body Mass Index; Cross-Sectional Studies; Diuretics; Female; Glomerular Filtrati

2014
Higher baseline serum uric acid is associated with poorer cognition but not rates of cognitive decline in women.
    Experimental gerontology, 2014, Volume: 60

    Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Cognition; Cognition Disorders; Cohort Studies; Cross-Se

2014
Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:12

    Topics: Aging; Allopurinol; Animal Feed; Animals; Apolipoproteins E; Arteriosclerosis; Benzbromarone; Diet;

2014
Association of increased carotid intima-media thickness and lower plasma levels of vitamin C and vitamin E in old age subjects: implications for Alzheimer's disease.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Ascorbic Acid; Carotid Intima-Media Thickness; Fe

2015
Lower uric Acid linked with cognitive dysfunction in the elderly.
    CNS & neurological disorders drug targets, 2015, Volume: 14, Issue:5

    Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Humans; Male; Mental Status Schedule; N

2015
Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
    Biochemical pharmacology, 2015, Sep-01, Volume: 97, Issue:1

    Topics: Aging; Allopurinol; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Ca

2015
Causes of Thickening of Carotid Intima-Media Thickness in Patients With Alcoholic Liver Disease: A Prospective Observational Study.
    Medicine, 2015, Volume: 94, Issue:28

    Topics: Aging; Blood Glucose; Body Mass Index; Carotid Arteries; Carotid Intima-Media Thickness; Cytokines;

2015
[EFFECT OF PROPARGYLGLYCINE UPON CARDIOHEMODYNAMICS IN OLD RATS].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2015, Volume: 61, Issue:4

    Topics: Adenosine Triphosphate; Aging; Alkynes; Animals; Blood Pressure; Diastole; Glycine; Heart Atria; Hyd

2015
Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women.
    Endocrine research, 2016, Volume: 41, Issue:2

    Topics: Aged; Aging; Exercise Therapy; Female; Humans; Independent Living; Insulin Resistance; Japan; Middle

2016
Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.
    Scientific reports, 2016, Feb-25, Volume: 6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Asian People; Blood Pressure; Blood Urea Nitrogen; China; Cho

2016
Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition.
    Metabolism: clinical and experimental, 2016, Volume: 65, Issue:4

    Topics: Aging; Blood Glucose; Blood Pressure; Body Composition; Body Mass Index; Female; Follow-Up Studies;

2016
Obesity and Age-Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations.
    Obesity (Silver Spring, Md.), 2016, Volume: 24, Issue:6

    Topics: Adult; Aged; Aging; Biomarkers; Blood Pressure; Body Mass Index; C-Reactive Protein; Cholesterol, HD

2016
Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause.
    Menopause (New York, N.Y.), 2017, Volume: 24, Issue:2

    Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Aging; Arachidonic Acid; C-Reactive Protein; Collage

2017
Adiponectin: possible link between metabolic stress and oxidative stress in the elderly.
    Aging clinical and experimental research, 2017, Volume: 29, Issue:4

    Topics: Adiponectin; Aged; Aging; Biomarkers; Case-Control Studies; Cholesterol, HDL; Female; Humans; Insuli

2017
The Power of Serum Uric Acid in Predicting Metabolic Syndrome Diminishes With Age in an Elderly Chinese Population.
    The journal of nutrition, health & aging, 2016, Volume: 20, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Asian People; Cross-Sectional Studies; Female; Humans; Longitudinal

2016
Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing.
    Neuroscience letters, 2017, 01-10, Volume: 637

    Topics: Aged; Aged, 80 and over; Aging; Beijing; Cognition; Cognition Disorders; Cross-Sectional Studies; Fe

2017
Longitudinal Association Between Serum Uric Acid and Arterial Stiffness: Results From the Baltimore Longitudinal Study of Aging.
    Hypertension (Dallas, Tex. : 1979), 2017, Volume: 69, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Baltimore; Biomarkers; Blood Pressure; Cardiovas

2017
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:6

    Topics: Aging; Apnea; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Female; Genotype; Gestational Age; Hum

2017
Uric acid and endothelial function in elderly community-dwelling subjects.
    Experimental gerontology, 2017, Volume: 89

    Topics: Acetylcholine; Aged; Aging; Biomarkers; Brachial Artery; Cardiovascular Diseases; Endothelium, Vascu

2017
The Role of Uric Acid for Predicting Future Metabolic Syndrome and Type 2 Diabetes in Older People.
    The journal of nutrition, health & aging, 2017, Volume: 21, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans;

2017
Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons.
    Mechanisms of ageing and development, 2008, Volume: 129, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Female; Follow-Up Studies; Hand Strength; Humans; Male; Muscle, Skel

2008
Factors contributing to increased serum urate in postmenopausal Japanese females.
    Climacteric : the journal of the International Menopause Society, 2009, Volume: 12, Issue:2

    Topics: Adult; Aging; Alcohol Drinking; Body Mass Index; Female; Homeostasis; Humans; Insulin Resistance; Ja

2009
Effect of exercise training on ethanol-induced oxidative damage in aged rats.
    Alcohol (Fayetteville, N.Y.), 2009, Volume: 43, Issue:1

    Topics: Aging; Alcohol Drinking; Animals; Antioxidants; Ascorbic Acid; Central Nervous System Depressants; E

2009
Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III.
    The journal of nutrition, health & aging, 2009, Volume: 13, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Female; Health Status; Health Survey

2009
Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter?
    The Journal of rheumatology, 2009, Volume: 36, Issue:5

    Topics: Aged; Aging; Blood Chemical Analysis; Female; Gout; Gout Suppressants; Health Expenditures; Humans;

2009
Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes.
    Diabetes/metabolism research and reviews, 2009, Volume: 25, Issue:6

    Topics: Adolescent; Aging; Blood Glucose; Body Mass Index; Child; Cohort Studies; Diabetes Mellitus, Type 1;

2009
Serum uric acid and prehypertension among Chinese adults.
    Journal of hypertension, 2009, Volume: 27, Issue:9

    Topics: Adiposity; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Asian People; Blood Glucose; China; Fe

2009
Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burden.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2009, Volume: 19, Issue:10

    Topics: Adult; Aged; Aging; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female;

2009
Effect of gender on main clinical chemistry parameters in aged rats.
    Current aging science, 2009, Volume: 2, Issue:1

    Topics: Aging; Albumins; Animals; Antioxidants; Bilirubin; Female; Homeostasis; Iron; Lipids; Male; Models,

2009
Biochemical responses of juvenile and adult Japanese quails to cyanobacterial biomass.
    Neuro endocrinology letters, 2009, Volume: 30 Suppl 1

    Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Biomass; Blood Glucose; Cholesterol, HDL; Coturn

2009
Evaluation of reference intervals for biomarkers sensitive to alcohol consumption, excess body weight and oxidative stress.
    Scandinavian journal of clinical and laboratory investigation, 2010, Volume: 70, Issue:2

    Topics: Adolescent; Adult; Aging; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Bioma

2010
Variation in the uric acid transporter gene (SLC2A9) and memory performance.
    Human molecular genetics, 2010, Jun-01, Volume: 19, Issue:11

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Body Mass Index; Child; Cognition; Female; Genetic Vari

2010
Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2010, Volume: 65, Issue:6

    Topics: Aged; Aging; Antioxidants; Apolipoprotein A-I; Apolipoprotein C-III; Aryldialkylphosphatase; Cholest

2010
Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men.
    Metabolism: clinical and experimental, 2011, Volume: 60, Issue:6

    Topics: Adult; Aging; Alcohol Drinking; Blood Chemical Analysis; Body Mass Index; Fatty Liver; Follow-Up Stu

2011
Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese.
    Clinical rheumatology, 2011, Volume: 30, Issue:6

    Topics: Adult; Aging; Asian People; Body Mass Index; China; Cross-Sectional Studies; Female; Humans; Hyperur

2011
[Mechanism of delta-sleep inducing peptide geroprotective activity].
    Advances in gerontology = Uspekhi gerontologii, 2011, Volume: 24, Issue:1

    Topics: Aging; Animals; Antioxidants; Body Weight; Brain; Ceruloplasmin; Delta Sleep-Inducing Peptide; Eryth

2011
Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome.
    Cardiovascular diabetology, 2012, Jan-10, Volume: 11

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Asian People; Biomarkers; Carotid Artery Diseases; Caro

2012
Oxidative stress increases continuously with BMI and age with unfavourable profiles in males.
    The aging male : the official journal of the International Society for the Study of the Aging Male, 2012, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Autoantibodies; Bilirubin; Body Mass Index; Chole

2012
Serum dehydroepiandrosterone-sulfate reflects age better than health status, and may increase with cigarette smoking and alcohol drinking in middle-aged men.
    Aging clinical and experimental research, 2012, Volume: 24, Issue:2

    Topics: Adult; Aging; Alcohol Drinking; Biomarkers; Dehydroepiandrosterone Sulfate; Exercise; Health Status;

2012
Uric acid levels in tissues and plasma of mice during aging.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:8

    Topics: Aging; Animals; Male; Mice; Mice, Inbred C57BL; Uric Acid

2012
Renal calcium, phosphorus, magnesium and uric acid handling: comparison between stage III chronic kidney disease patients and healthy oldest old.
    International urology and nephrology, 2012, Volume: 44, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Calcium; Case-Control Studies; Creatinine; Female; Glomerular

2012
Age-related change in kidney function, its influencing factors, and association with asymptomatic carotid atherosclerosis in healthy individuals--a 5-year follow-up study.
    Maturitas, 2012, Volume: 73, Issue:3

    Topics: Age Factors; Aged; Aging; Blood Pressure; Carotid Artery Diseases; China; Cholesterol, LDL; Cross-Se

2012
Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambuì Cohort Study of Ageing (1997-2008).
    Hypertension research : official journal of the Japanese Society of Hypertension, 2013, Volume: 36, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Alleles; Apolipoproteins E; Blood Pressure; Brazil; Cohort Studies;

2013
Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50-74 years.
    Geriatrics & gerontology international, 2013, Volume: 13, Issue:3

    Topics: Aged; Aging; China; Cognition; Cognition Disorders; Cross-Sectional Studies; Disease Progression; Fe

2013
Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2002, Volume: 57, Issue:10

    Topics: Adult; Age Factors; Aging; Alcohol Drinking; Body Mass Index; Cohort Studies; Female; Follow-Up Stud

2002
A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study.
    Environmental health perspectives, 2003, Volume: 111, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Bone and Bones; Creatinine; Cross-Sectional Studies; Environm

2003
Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:4

    Topics: Activities of Daily Living; Aged; Aging; Antioxidants; Ascorbic Acid; Body Mass Index; Bone and Bone

2003
Serum uric acid levels in men and women past the age of 65 years.
    Journal of gerontology, 1953, Volume: 8, Issue:4

    Topics: Aged; Aging; Female; Humans; Male; Uric Acid

1953
The urinary excretion of protein, non-protein nitrogen, creatinine and uric acid in ageing male rats.
    Gerontologia, 1958, Volume: 2, Issue:1

    Topics: Aging; Animals; Body Fluids; Creatinine; Male; Nitrogen; Proteinuria; Rats; Uric Acid

1958
Factors affecting the composition of chicken blood and tissues.
    Annals of biochemistry and experimental medicine, 1962, Volume: 22

    Topics: Aging; Animals; Bone and Bones; Chickens; Cholesterol; Growth; Humans; Intestines; Kidney; Lipids; L

1962
[Blood uric acid of chickens. Variations as a function of age and diet].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1962, Volume: 156

    Topics: Aging; Animals; Chickens; Diet; Humans; Meat; Poultry; Uric Acid

1962
BLOOD URIC ACID VALUES AS RELATED TO SEX AND AGE.
    JAMA, 1964, Sep-28, Volume: 189

    Topics: Aging; Blood; Humans; Research; Sex; Statistics as Topic; Uric Acid

1964
RENAL AMMONIUM EXCRETION AND URINARY PH IN IDIOPATHIC URIC ACID LITHIASIS.
    The Journal of urology, 1964, Volume: 92

    Topics: Aging; Ammonium Chloride; Ammonium Compounds; Biomedical Research; Geriatrics; Humans; Hydrogen-Ion

1964
EFFECT OF SULFINPYRAZONE ON SERUM URIC ACID IN GOUT. A LONG-TERM STUDY.
    Geriatrics, 1964, Volume: 19

    Topics: Adolescent; Aging; Blood; Drug Therapy; Geriatrics; Gout; Longitudinal Studies; Metabolism; Phenylbu

1964
[DETERMINATION OF BLOOD URIC ACID IN NORMAL SUBJECTS BY THE URICASE METHOD; VARIATIONS AS A FUNCTION OF AGE AND SEX].
    Schweizerische medizinische Wochenschrift, 1964, Jul-11, Volume: 94

    Topics: Aging; Biometry; Blood; Colorimetry; Humans; Sex; Spectrophotometry; Statistics as Topic; Urate Oxid

1964
[BLOOD CHOLESTEROL AND TRIGLYCERIDES IN 2 OCCUPATIONAL GROUPS. FIRST RESULTS OF AN EPIDEMIOLOGIC INVESTIGATION ON THE FACTORS OF ATHEROSCLEROSIS].
    Revue de l'atherosclerose, 1964, Volume: 6

    Topics: Adolescent; Aging; Arteriosclerosis; Atherosclerosis; Blood; Blood Pressure; Body Weight; Cholestero

1964
THE DISTRIBUTION OF SERUM URIC ACID VALUES IN A POPULATION UNSELECTED AS TO GOUT OR HYPERURICEMIA: TECUMSEH, MICHIGAN 1959-1960.
    The American journal of medicine, 1965, Volume: 39

    Topics: Aging; Blood Chemical Analysis; Gout; Humans; Hyperuricemia; Mass Screening; Michigan; Sex; Uric Aci

1965
Nutritional status of the aging. VI. Serum protein, blood nonprotein nitrogen, uric acid and creatinine.
    The Journal of nutrition, 1955, Apr-11, Volume: 55, Issue:4

    Topics: Aged; Aging; Blood; Blood Proteins; Creatinine; Humans; Nitrogen; Nutritional Status; Uric Acid

1955
Influence of coronary artery disease risk factors on baroreflex sensitivity in the elderly.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2003, Volume: 13, Issue:5

    Topics: Activities of Daily Living; Aged; Aging; Alcohol Drinking; Baroreflex; Blood Cell Count; Blood Gluco

2003
Low molecular weight antioxidants released from the skin's epidermal layers: an age dependent phenomenon in the rat.
    Experimental gerontology, 2004, Volume: 39, Issue:1

    Topics: Adult; Aging; Animals; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; Electrophy

2004
Effect of sunlight exposure and aging on skin surface lipids and urate.
    Experimental dermatology, 2003, Volume: 12 Suppl 2

    Topics: Aging; Chromatography, High Pressure Liquid; Environmental Exposure; Epidermis; Fatty Acids, Noneste

2003
Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 341, Issue:1-2

    Topics: Adolescent; Aging; Allantoin; Antioxidants; Child; Chromatography, High Pressure Liquid; Down Syndro

2004
Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies.
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:5

    Topics: Aging; Antioxidants; Ascorbic Acid; Bronchoalveolar Lavage Fluid; Bronchopulmonary Dysplasia; Cohort

2004
Plasma chemistry reference values from captive red-legged partridges (Alectoris rufa).
    British poultry science, 2004, Volume: 45, Issue:4

    Topics: Aging; Animals; Blood Glucose; Blood Proteins; Body Weight; Cholesterol; Creatinine; Female; Gallifo

2004
Disturbances in renal autoregulation and the susceptibility to hypertension-induced chronic kidney disease.
    The American journal of the medical sciences, 2004, Volume: 328, Issue:6

    Topics: Aging; Animals; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Fetal Growth Retar

2004
Impairment of the ability of the injured aged brain in elevating urate and ascorbate.
    Experimental gerontology, 2006, Volume: 41, Issue:3

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Axons; Brain Injuries; Corpus Callosum; Extracellular M

2006
Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes.
    Free radical research, 2006, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aldehydes; Biomarkers; Erythrocytes; Female; Glut

2006
Comparison of plasma uric acid levels in five varieties of the domestic turkey, Meleagris gallopavo.
    Poultry science, 2006, Volume: 85, Issue:10

    Topics: Aging; Animals; Female; Male; Turkeys; Uric Acid

2006
Uric acid and the development of hypertension: the normative aging study.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 48, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Follow-Up Studies; Humans; Hypertension; Hyperuricemia; Longi

2006
Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats.
    Physiological research, 2007, Volume: 56, Issue:6

    Topics: Aging; Animals; Antioxidants; Chromans; Comet Assay; DNA; Heart; Lipid Metabolism; Lymphocytes; Male

2007
Serum uric acid and cognitive function in community-dwelling older adults.
    Neuropsychology, 2007, Volume: 21, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Body Mass Index; Cognition; Female; Geriatric Assessment; Humans; Ma

2007
Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity.
    European journal of clinical nutrition, 2007, Volume: 61, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Antioxidants; Ascorbic Acid; Female; Glutathione Peroxidase; Humans;

2007
Serum antioxidant capacity in polymorphic light eruption.
    Acta dermato-venereologica, 2007, Volume: 87, Issue:3

    Topics: Adult; Aged; Aging; Ascorbic Acid; Bilirubin; Case-Control Studies; Female; Glutathione; Humans; Mal

2007
Dynamic changes in parameters of redox balance after mild heat stress in aged laying hens (Gallus gallus domesticus).
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2008, Volume: 147, Issue:1

    Topics: Acute Disease; Age Factors; Aging; Animals; Antioxidants; Biomarkers; Blood Glucose; Body Temperatur

2008
Serum uric acid concentration among business executives. With observations on other coronary heart disease risk factors.
    Annals of internal medicine, 1967, Volume: 66, Issue:5

    Topics: Adult; Aging; Alcoholic Beverages; Body Constitution; Cholesterol; Coronary Disease; Humans; Male; M

1967
[Aging as inversion of growth: reaction of uric acid (author's transl)].
    Aktuelle Gerontologie, 1981, Volume: 11, Issue:1

    Topics: Adult; Aged; Aging; Female; Humans; Male; Middle Aged; Nucleic Acids; Sex Factors; Uric Acid

1981
Hormonal aspects of human gout--excretion of adrenal hormone derivatives in gouty patients.
    Clinica chimica acta; international journal of clinical chemistry, 1983, Jun-15, Volume: 130, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Aged; Aging; Allopurinol; Androsterone; Dehydroepiandrosterone; Etio

1983
The influence of intravenous furosemide on the renal excretion pattern of protein and protein degradation products.
    Acta pharmacologica et toxicologica, 1984, Volume: 54, Issue:5

    Topics: Aged; Aging; Albuminuria; beta 2-Microglobulin; Creatine; Furosemide; Humans; Hydrogen-Ion Concentra

1984
Urate and ascorbate: their possible roles as antioxidants in determining longevity of mammalian species.
    Archives of gerontology and geriatrics, 1984, Volume: 3, Issue:4

    Topics: Aging; Animals; Ascorbic Acid; Brain; Energy Metabolism; Feeding Behavior; Free Radicals; Humans; Lo

1984
Blood parameters of one-year-old and seven-year old partridges (Alectoris chukar).
    Poultry science, 1983, Volume: 62, Issue:12

    Topics: Aging; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Birds; Blood Glucose; Blood Prote

1983
Metabolic changes in ageing Drosophila melanogaster.
    Experimental gerontology, 1980, Volume: 15, Issue:3

    Topics: Aging; Animals; Dietary Carbohydrates; Dietary Fats; Drosophila melanogaster; Feces; Glycogen; Male;

1980
[Blood uric acid and coronary disease. Direct role or statistical relation to lipid disorders].
    Archives des maladies du coeur et des vaisseaux, 1981, Volume: 74, Issue:11

    Topics: Adult; Aged; Aging; Coronary Disease; Female; Humans; Lipids; Male; Middle Aged; Sex Factors; Uric A

1981
Trends in serum uric acid levels 1961--1980.
    Arthritis and rheumatism, 1983, Volume: 26, Issue:1

    Topics: Adult; Aged; Aging; Alcohol Drinking; Body Weight; Diet; Humans; Longitudinal Studies; Male; Middle

1983
Determinants of change in blood pressure during childhood.
    American journal of epidemiology, 1983, Volume: 117, Issue:6

    Topics: Adolescent; Adult; Aging; Blood Pressure; Blood Pressure Determination; Body Height; Body Weight; Ch

1983
Synthesis of 3-N-ribosyluric acid 5'-monophosphate by red cells of the bovine fetus.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1983, Volume: 75, Issue:3

    Topics: Aging; Animals; Cattle; Erythrocytes; Female; Fetus; Orotate Phosphoribosyltransferase; Pregnancy; R

1983
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:11

    Topics: Adult; Aging; Animals; Antioxidants; Ascorbic Acid; Biological Evolution; Brain; Digestive System; E

1981
Basic alterations in serum levels of several chemical substances in Brattleboro rats.
    Annals of the New York Academy of Sciences, 1982, Volume: 394

    Topics: Aging; Alkaline Phosphatase; Animals; Blood Glucose; Blood Proteins; Creatinine; Diabetes Insipidus;

1982
Serum high density lipoprotein cholesterol: as a cholesterol risk factor index for atherosclerotic diseases.
    Japanese heart journal, 1982, Volume: 23, Issue:4

    Topics: Aging; Arteriosclerosis; Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Coronary Dise

1982
Long-term follow-up of incorporation of 15N from glycine into uric acid in gout.
    The American journal of medicine, 1981, Volume: 70, Issue:4

    Topics: Adult; Aged; Aging; Follow-Up Studies; Glycine; Gout; Humans; Male; Middle Aged; Nitrogen; Nitrogen

1981
[Serum uric acid - the longitudinal behavior and age (author's transl)].
    Zeitschrift fur Alternsforschung, 1980, Volume: 35, Issue:6

    Topics: Adult; Aged; Aging; Body Weight; Cholesterol; Female; Humans; Longitudinal Studies; Male; Middle Age

1980
[Nitrogen excretion of Helix aspersa Müller (Mollusca Gastropoda Pulmonata)].
    Annales de la nutrition et de l'alimentation, 1980, Volume: 34, Issue:4

    Topics: Aging; Ammonia; Animals; Helix, Snails; Nitrogen; Seasons; Urate Oxidase; Urea; Urease; Uric Acid

1980
[Metabolic risk factors in the very old].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1981, Volume: 36, Issue:5

    Topics: Aged; Aging; Cardiovascular Diseases; Coronary Disease; Diabetes Complications; Female; Humans; Hype

1981
[Frequency of risk factors in cerebrovascular disease and their effect on the course and outcome. Study on 423 hospitalized patients].
    Minerva medica, 1981, Nov-10, Volume: 72, Issue:44

    Topics: Aged; Aging; Arrhythmias, Cardiac; Cerebrovascular Disorders; Coronary Disease; Diabetes Complicatio

1981
A dynamic analysis of chronic disease development: a study of sex specific changes in coronary heart disease incidence and risk factors in Framingham.
    International journal of epidemiology, 1981, Volume: 10, Issue:4

    Topics: Adult; Aging; Blood Pressure; Cholesterol; Coronary Disease; Female; Humans; Longitudinal Studies; M

1981
Serum uric acid: correlation with biochemical, anthropometric, clinical and behavioral parameters in 10,000 Israeli men.
    Journal of chronic diseases, 1980, Volume: 33, Issue:7

    Topics: Adult; Aging; Anthropometry; Coronary Disease; Diabetes Mellitus; Epidemiologic Methods; Ethnicity;

1980
Urate excretion in old age.
    Gerontology, 1980, Volume: 26, Issue:5

    Topics: Aged; Aging; Bacteriuria; Female; Humans; Male; Middle Aged; Uric Acid

1980
Plasma high-density lipoprotein cholesterol in children and young adults. The Lipid Research Clinics Program Prevalence Study.
    Circulation, 1980, Volume: 62, Issue:4 Pt 2

    Topics: Adolescent; Adult; Aging; Body Height; Body Weight; Child; Cholesterol; Creatinine; Diet; Female; He

1980
An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans.
    Mutation research, 1995, Volume: 338, Issue:1-6

    Topics: Adult; Aged; Aging; Antioxidants; Bilirubin; Catalase; Ceruloplasmin; DNA Damage; DNA Repair; DNA, S

1995
Cellular defence mechanisms in the striatum of young and aged rats subchronically exposed to manganese.
    Neuropharmacology, 1995, Volume: 34, Issue:3

    Topics: Aging; Animals; Ascorbic Acid; Dopamine; Glutathione; Male; Manganese Poisoning; Neostriatum; Oxidat

1995
Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study.
    American journal of epidemiology, 1995, Aug-01, Volume: 142, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Anthropometry; Body Constitution; Cohort St

1995
Oxidative stress and human ageing.
    Biochemical Society transactions, 1995, Volume: 23, Issue:2

    Topics: Adult; Age Factors; Aged; Aging; Antioxidants; Bilirubin; Cells, Cultured; Chromosome Aberrations; D

1995
Monoaminergic systems activity and cellular defense mechanisms in the brainstem of young and aged rats subchronically exposed to manganese.
    Neuroscience letters, 1994, Aug-15, Volume: 177, Issue:1-2

    Topics: Aging; Animals; Biogenic Monoamines; Biomarkers; Brain Stem; Chlorides; Dehydroascorbic Acid; Drug A

1994
[The effects of aging on renal function test].
    Nihon Sanka Fujinka Gakkai zasshi, 1994, Volume: 46, Issue:12

    Topics: Adult; Aged; Aging; Blood Urea Nitrogen; Creatinine; Female; Humans; Kidney Function Tests; Menopaus

1994
Association between serum uric acid and some cardiovascular risk factors in a Chinese population.
    Postgraduate medical journal, 1994, Volume: 70, Issue:825

    Topics: Adult; Aging; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Female; Hong Kong; Humans; Male

1994
Effects of ageing on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat.
    Neuroscience letters, 1993, Sep-03, Volume: 159, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Antioxidants; Ascorbic Acid; Brain Stem; Corpus Stri

1993
The effect of age on concentrations of monoamines, amino acids, and their related substances in the cerebrospinal fluid.
    Journal of neural transmission. Parkinson's disease and dementia section, 1993, Volume: 5, Issue:3

    Topics: Adult; Aged; Aging; Amino Acids; Biogenic Monoamines; Blood-Brain Barrier; Brain Chemistry; Chromato

1993
Incorporation of [14C]hypoxanthine into cardiac adenine nucleotides: effect of aging and post-ischemic reperfusion.
    Biochimica et biophysica acta, 1993, Jan-22, Volume: 1180, Issue:3

    Topics: Adenine Nucleotides; Aging; Animals; Hypoxanthine; Hypoxanthines; Male; Myocardial Ischemia; Myocard

1993
Age-dependent differences of ATP breakdown and ATP-catabolite release in ischemic and reperfused hearts.
    Mechanisms of ageing and development, 1993, Volume: 67, Issue:1-2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aging; Animals; Energy Metabolism; In Vitro Technique

1993
The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years.
    European heart journal, 1993, Volume: 14, Issue:5

    Topics: Aged; Aging; Blood Pressure; Blood Viscosity; Cross-Sectional Studies; Female; Fibrinogen; Hematocri

1993
Mixed monosodium urate and calcium pyrophosphate crystal-induced arthropathy. A review of seventeen cases.
    Revue du rhumatisme (English ed.), 1996, Volume: 63, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arthrography; Calcium Pyrophosphate; Crystallization; Female;

1996
Gout, uric acid, albumin, and aging.
    Journal of the National Medical Association, 1996, Volume: 88, Issue:8

    Topics: Aging; Gout; Humans; Uric Acid

1996
Age-related changes in the peroxyl radical scavenging capacity of human plasma.
    Free radical biology & medicine, 1997, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Antioxidants; Ascorbic Acid; Chromans; F

1997
In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans.
    Mutation research, 1997, Jun-09, Volume: 377, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Antioxidants; Bilirubin; Catalase; Cells, Cult

1997
Duodenal flow of microbial nitrogen estimated from urinary excretion of purine derivatives in calves after early weaning.
    Journal of animal science, 1997, Volume: 75, Issue:7

    Topics: Aging; Allantoin; Animals; Body Weight; Cattle; Digestion; Duodenum; Eating; Male; Nitrogen; Purines

1997
Social and biological predictors of early menopause: a model for premature aging.
    Journal of internal medicine, 1997, Volume: 242, Issue:4

    Topics: Adult; Aging; Blood Glucose; Blood Pressure; Body Mass Index; Creatinine; Denmark; Female; Health St

1997
Purine metabolism of uric acid urolithiasis induced in newborn piglets.
    The Journal of veterinary medical science, 1998, Volume: 60, Issue:2

    Topics: Aging; Allantoin; Animals; Animals, Newborn; Body Weight; Hypoxanthine; Purines; Swine; Swine Diseas

1998
Serum selenium levels as indicators of body status in cancer patients and their relationship with other nutritional and biochemical markers.
    The Science of the total environment, 1998, Apr-08, Volume: 212, Issue:2-3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers

1998
Lung lining fluid antioxidants in male broilers: age-related changes under thermoneutral and cold temperature conditions.
    Poultry science, 1998, Volume: 77, Issue:12

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Body Fluids; Chickens; Chromatography, High Pressure Li

1998
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients.
    Pediatric research, 1999, Volume: 45, Issue:1

    Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Th

1999
Age-related plasma chemistry findings in the buff-crested bustard (Eupodotis ruficrista gindiana).
    Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 1998, Volume: 45, Issue:10

    Topics: Aging; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Birds; Blood Chemical Analysis; B

1998
Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats.
    Life sciences, 1999, Volume: 64, Issue:8

    Topics: Aging; Angiotensin II; Animals; Antioxidants; Ascorbic Acid; Biflavonoids; Blood Glucose; Body Weigh

1999
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
    Biochemical pharmacology, 1998, May-01, Volume: 55, Issue:9

    Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 En

1998
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1999, Volume: 54, Issue:4

    Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Enzyme

1999
Cancer mortality trends in two cohorts of elderly people having different life-styles.
    Aging (Milan, Italy), 1999, Volume: 11, Issue:1

    Topics: Age Distribution; Aged; Aging; Alanine Transaminase; Alkaline Phosphatase; Body Mass Index; Cohort S

1999
Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study.
    Annals of internal medicine, 1999, Jul-06, Volume: 131, Issue:1

    Topics: Age Distribution; Aging; Boston; Cardiovascular Diseases; Cause of Death; Female; Follow-Up Studies;

1999
Serum urate is associated with baseline renal dysfunction but not survival or deterioration in renal function in malignant phase hypertension.
    Journal of hypertension, 2000, Volume: 18, Issue:1

    Topics: Aged; Aging; Blood Pressure; Cause of Death; Creatinine; Female; Follow-Up Studies; Humans; Hyperten

2000
Age-related change in relationship between body-mass index, serum sialic acid, and atherogenic risk factors.
    Journal of atherosclerosis and thrombosis, 1998, Volume: 5, Issue:2

    Topics: Adult; Aging; Arteriosclerosis; Biomarkers; Blood Pressure; Body Mass Index; Cholesterol; Cholestero

1998
Plasma antioxidants and longevity: a study on healthy centenarians.
    Free radical biology & medicine, 2000, Apr-15, Volume: 28, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; Antioxidants; Ascorbic Acid; Carotenoids; Erythrocytes; Female; Glut

2000
Hematology and serum chemistries of nestling bald eagles (Haliaeetus leucocephalus) in the lower peninsula of MI, USA.
    Chemosphere, 2000, Volume: 41, Issue:10

    Topics: Aging; Alkaline Phosphatase; Blood Proteins; Blood Urea Nitrogen; Cholesterol; Eagles; Environmental

2000
Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed to manganese.
    Aging (Milan, Italy), 2000, Volume: 12, Issue:5

    Topics: Aging; Animals; Brain Stem; Corpus Striatum; Energy Metabolism; Glutamic Acid; Hypoxanthine; Male; M

2000
Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats.
    Aging (Milan, Italy), 2000, Volume: 12, Issue:6

    Topics: Aging; Animals; Antimetabolites; Ascorbic Acid; Brain; Buthionine Sulfoximine; Dehydroascorbic Acid;

2000
Dehydroascorbic acid and oxidative stress in haemodialysis patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:3

    Topics: Aging; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Case-Control Studies;

2001
Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2001, Volume: 129, Issue:2

    Topics: Aging; Allopurinol; Animals; Antimetabolites; Arginine; Blood Glucose; Body Weight; Chickens; Cross-

2001
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
    The European journal of neuroscience, 2001, Volume: 14, Issue:9

    Topics: Aging; Animals; Ascorbic Acid; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Respons

2001
Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:6

    Topics: Adult; Aged; Aging; Cohort Studies; Creatinine; Female; Humans; Male; Mass Screening; Middle Aged; R

2001
Is serum uric acid level associated with all-cause mortality in high-functioning older persons: MacArthur studies of successful aging?
    Journal of the American Geriatrics Society, 2001, Volume: 49, Issue:12

    Topics: Aged; Aging; Cardiovascular Diseases; Cause of Death; Cohort Studies; Female; Humans; Life Style; Ma

2001
Development of a biochemical profile for mass-reared boll weevils (Coleoptera: Curculionidae).
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1976, Volume: 53, Issue:1

    Topics: Aging; Animals; Cholesterol; Coleoptera; Female; Lipid Metabolism; Male; Proteins; Sex Factors; Uric

1976
Changes in the acid-soluble nucleotide composition of red cells of cattle at various ages.
    Biochemical and biophysical research communications, 1976, May-23, Volume: 76, Issue:2

    Topics: Adenine Nucleotides; Aging; Animals; Cattle; Erythrocytes; Female; Guanosine Triphosphate; NAD; NADP

1976
Transport ontogeny and selective substrate stimulation as models for identification of multiple renal organic anion transport systems.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:3

    Topics: 4-Aminobenzoic Acid; Aging; Animals; Animals, Newborn; Anions; Aspirin; Biological Transport, Active

1977
Peritoneal dialysis is reinstated.
    Journal of dialysis, 1978, Volume: 2, Issue:3

    Topics: Aged; Aging; Blood Urea Nitrogen; Catheters, Indwelling; Child; Child, Preschool; Chronic Disease; C

1978
[Distribution and correlations of serum uric-acid in two French adult populations : 13,885 men and 6,861 women (author's transl)].
    Pathologie-biologie, 1978, Volume: 26, Issue:8

    Topics: Adult; Aged; Aging; Blood Pressure; Body Weight; Cholesterol; Creatinine; Female; Humans; Male; Midd

1978
Age-dependent changes in blood monocyte populations in man.
    Clinical and experimental immunology, 1979, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Child; Female; Humans; Leukocyte Count; Male; Middle Aged; Monocytes

1979
Caffeine metabolism in the newborn.
    Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:4

    Topics: Adult; Aging; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Humans; Infant; Inf

1979
[Metabolic studies in the longitudinal study of the Gerontological Research Project].
    Zeitschrift fur Alternsforschung, 1978, Volume: 33, Issue:4

    Topics: Adult; Aged; Aging; Cholesterol; Fatty Acids; Female; Germany, East; Humans; Longitudinal Studies; M

1978
Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies.
    The American journal of medicine, 1975, Volume: 59, Issue:5

    Topics: Adult; Aged; Aging; Calculi; Follow-Up Studies; Glomerular Filtration Rate; Gout; Humans; Inulin; Ki

1975
The effect of age on the inflammatory response to arthritis-associated crystals.
    Australian and New Zealand journal of medicine, 1992, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Arthritis; Cell Death; Child; Crystallization; Durapati

1992
Human liver xanthine oxidase: nature and extent of individual variation.
    Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Child; Female; Humans; Hydroge

1991
Uric acid content of Drosophila decreases with aging.
    Experimental gerontology, 1991, Volume: 26, Issue:6

    Topics: Aging; Animals; Drosophila melanogaster; Male; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines

1991
The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase.
    Journal of inherited metabolic disease, 1991, Volume: 14, Issue:2

    Topics: Adenosine Triphosphate; Adult; Aging; Body Mass Index; Creatinine; Exercise; Female; Humans; Hypoxan

1991
Does xanthine oxidase cause damage during myocardial ischemia?
    Bratislavske lekarske listy, 1991, Volume: 92, Issue:1

    Topics: Aging; Animals; Cattle; Coronary Disease; Guinea Pigs; Humans; In Vitro Techniques; Mice; Myocardium

1991
Uric acid levels in southern Germany in 1989. A comparison with studies from 1962, 1971, and 1984.
    Klinische Wochenschrift, 1990, Dec-17, Volume: 68, Issue:24

    Topics: Adult; Aged; Aging; Female; Germany; Gout; Humans; Kidney Calculi; Male; Middle Aged; Population Sur

1990
Effects of uric acid and caffeine on A1 adenosine receptor binding in developing rat brain.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:4

    Topics: Adenosine; Aging; Animals; Binding, Competitive; Brain; Caffeine; Male; Oxonic Acid; Rats; Rats, Inb

1990
Arterial disease risk factors and angiographic evidence of atheroma of the carotid artery.
    Stroke, 1989, Volume: 20, Issue:11

    Topics: Aging; Angiography, Digital Subtraction; Arteriosclerosis; Carotid Artery Diseases; Cerebrovascular

1989
Increased uric acid in the developing brain and spinal cord following cytomegalovirus infection.
    Journal of neurochemistry, 1989, Volume: 53, Issue:6

    Topics: Aging; Animals; Brain; Cytomegalovirus Infections; Mice; Mice, Inbred BALB C; Organ Specificity; Ref

1989
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:2

    Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; T

1989
Studies on normal and abnormal excretion patterns of uric acid in Bahawalpur.
    JPMA. The Journal of the Pakistan Medical Association, 1987, Volume: 37, Issue:10

    Topics: Adolescent; Adult; Aged; Aging; Female; Gout; Humans; Male; Middle Aged; Pakistan; Urban Population;

1987
Theophylline pharmacokinetics in normal elderly subjects.
    Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5

    Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theo

1988
Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats.
    Biochimica et biophysica acta, 1988, Sep-08, Volume: 966, Issue:3

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Free Radicals; Glutathione; Male; Organ Size; Rats; Tis

1988
Distribution of aromatic and fluorescent compounds within single human lenses.
    Experimental eye research, 1987, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Fluorescence;

1987
Prevalence of rheumatoid arthritis, osteoarthritis, chondrocalcinosis and gouty arthritis at age 79.
    The Journal of rheumatology, 1986, Volume: 13, Issue:3

    Topics: Aged; Aging; Arthritis; Arthritis, Rheumatoid; Chondrocalcinosis; Female; Finger Joint; Gout; Hip Jo

1986
Body weight and coronary disease risk: patterns of risk factor change associated with long-term weight change. The Normative Aging Study.
    American journal of epidemiology, 1986, Volume: 124, Issue:3

    Topics: Adult; Aged; Aging; Blood Glucose; Blood Pressure; Body Weight; Coronary Disease; Humans; Longitudin

1986
[The effects of physiologic alterations, disease states and drugs on serum uric acid levels in an elderly population].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1986, Volume: 23, Issue:5

    Topics: Aged; Aged, 80 and over; Aging; Diuretics; Female; Humans; Male; Middle Aged; Uric Acid

1986
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
    The American journal of medicine, 1987, Volume: 82, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M

1987
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
    The American journal of medicine, 1987, Volume: 82, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M

1987
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
    The American journal of medicine, 1987, Volume: 82, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M

1987
Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.
    The American journal of medicine, 1987, Volume: 82, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis; Gout; Humans; Hypertension; Male; Massachusetts; M

1987
Relationships between red cell cation contents and blood pressure level.
    Japanese heart journal, 1985, Volume: 26, Issue:6

    Topics: Adult; Aging; Blood Glucose; Blood Pressure; Erythrocytes; Hematocrit; Humans; Hypertension; Middle

1985
The liver is an organ site for the release of inosine metabolized by non-glycolytic pig red cells.
    Biochimica et biophysica acta, 1985, Mar-08, Volume: 838, Issue:3

    Topics: Adenosine Triphosphate; Aging; Animals; Energy Metabolism; Erythrocytes; Glycolysis; Hypoxanthine; H

1985
Biological and social predictors of health in an aging cohort.
    Journal of chronic diseases, 1985, Volume: 38, Issue:5

    Topics: Aged; Aging; Alcohol Drinking; Anthropometry; Blood Glucose; Blood Pressure; Chronic Disease; Epidem

1985
Objectives, organization, and results of the Leipzig longitudinal study.
    Age and ageing, 1985, Volume: 14, Issue:1

    Topics: Adult; Aging; Blood Pressure; Cholesterol; Fatty Acids; Female; Germany, East; Humans; Longitudinal

1985
The severity of infection stones compared to other stones in the upper urinary tract.
    Scandinavian journal of urology and nephrology, 1985, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Calcium; Cystine; Female; Humans; Kidney Calculi; Male; Middle Aged;

1985
Problems of interpretation of laboratory findings in the old.
    British medical journal, 1973, Nov-10, Volume: 4, Issue:5888

    Topics: Aged; Aging; Anemia, Hypochromic; Blood Glucose; Blood Sedimentation; Calcium; Cholesterol; Clinical

1973
Development of renal gluconeogenesis in chicks fed high fat and high protein "carbohydrate-free" diets.
    The Journal of nutrition, 1973, Volume: 103, Issue:2

    Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Chick Embryo; Chickens; D

1973
[Clinico-chemical findings in 41 centenarians compared to younger stages of life].
    Klinische Wochenschrift, 1973, Feb-15, Volume: 51, Issue:4

    Topics: Adult; Age Factors; Aged; Aging; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood

1973
[Changes of clearance values in the aged].
    Fortschritte der Medizin, 1973, Jan-25, Volume: 91, Issue:3

    Topics: Aged; Aging; Aminohippuric Acids; Blood Urea Nitrogen; Creatinine; Female; Humans; Inulin; Kidney Fu

1973
[Normal values of plasma uric acid in South Germany. Comparison with determinations made ten years ago (author's transl)].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1973, Volume: 11, Issue:8

    Topics: ABO Blood-Group System; Adolescent; Adult; Aging; Blood Donors; Body Weight; Diet; Dietary Proteins;

1973
Age dependency of mean values in blood and blood serum of healthy Dutch school children between 4 and 13 years of age.
    Clinica chimica acta; international journal of clinical chemistry, 1973, Oct-30, Volume: 48, Issue:3

    Topics: Adolescent; Aging; Blood; Blood Proteins; Body Height; Body Surface Area; Body Weight; Calcium; Chil

1973
Retrospective study of men who had undergone myocardial infarction at the age of 40 years or younger.
    Cor et vasa, 1974, Volume: 16, Issue:2

    Topics: Adult; Age Factors; Aged; Aging; Angina Pectoris; Arteriosclerosis; Blood Glucose; Blood Pressure; C

1974
Uric acid excretion in infancy.
    Advances in experimental medicine and biology, 1974, Volume: 41

    Topics: Aging; Birth Weight; Body Weight; Child; Child, Preschool; Female; Humans; Hydrogen-Ion Concentratio

1974
Effect of allopurinol on the accumulation of xanthine dehydrogenase in liver and pancreas of chickens after hatching.
    Archives of biochemistry and biophysics, 1972, Volume: 148, Issue:1

    Topics: Aging; Allopurinol; Amino Acids; Ammonium Sulfate; Animals; Carbon Isotopes; Chemical Precipitation;

1972
A filter paper sampling method for the uric acid:creatinine ratio in urine. Normal values in the the newborn.
    Pediatrics, 1972, Volume: 49, Issue:1

    Topics: Aging; Creatinine; Female; Filtration; Humans; Infant, Newborn; Male; Mass Screening; Methods; Paper

1972
[Changes in blood chemical components in the aged].
    Rinsho byori. The Japanese journal of clinical pathology, 1971, Volume: 19

    Topics: Aged; Aging; Blood Proteins; Blood Urea Nitrogen; Cholesterol; Female; Humans; Male; Middle Aged; Ur

1971
Biochemical normals in Nigerians with particular reference to electrolytes and urea.
    Clinica chimica acta; international journal of clinical chemistry, 1970, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Aging; Bicarbonates; Calcium; Child; Child, Preschool; Electrolytes; Female; Huma

1970
The total nitrogen, protein, amino acid and uric acid ntent of ageing Drosophila.
    Experimental gerontology, 1970, Volume: 5, Issue:3

    Topics: Aging; Amino Acids; Animals; Body Weight; Drosophila; Indicators and Reagents; Male; Nitrogen; Prote

1970
[Comparison between blood uric acid values in normal aged patients and in hypertensive, obese or diabetic subjects].
    Giornale di gerontologia, 1967, Volume: 15, Issue:3

    Topics: Aged; Aging; Diabetes Mellitus; Female; Humans; Hypertension; Male; Obesity; Uric Acid

1967
[Changes in blood uric acid induced by diuretic treatment in aged subjects].
    Giornale di gerontologia, 1967, Volume: 15, Issue:3

    Topics: Aged; Aging; Diuretics; Humans; Uric Acid

1967
[Cholesterol and uric acid in relation to age, sex and body weight. Statistical findings on 5000 normal and arteriosclerotic subjects (from the cases of the Clinica Medica and the Ambulatorio in the Istituto de Gerontologia of Florence)].
    Giornale di gerontologia, 1965, Volume: 13, Issue:9

    Topics: Adult; Aged; Aging; Arteriosclerosis; Body Weight; Cholesterol; Female; Humans; In Vitro Techniques;

1965
[Uricemia in the senile age].
    Giornale di gerontologia. Supplemento, 1966, Volume: 35

    Topics: Aged; Aging; Female; Gout; Humans; Male; Uric Acid

1966