Page last updated: 2024-10-20

uric acid and Adolescent Obesity

uric acid has been researched along with Adolescent Obesity in 44 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
"To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents."9.22Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance. ( Chan, TF; Huang, HL; Lee, CH; Lee, CY; Lin, WT; Tsai, S; Wang, TN; Wu, PW; Yang, YC, 2016)
"Associations between body mass index (BMI)- standard deviation score (SDS)/waist-to-height ratio (WHtR) were studied with (i) serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) and (ii) cardiometabolic risk markers in children with obesity, considering sex, pubertal development, and degree of weight loss/type of patient care."8.31Uric acid and gamma-glutamyl-transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the ( Bergjohann, L; Dannemann, A; Holl, RW; Leipold, G; Prinz, N; Reinehr, T; Weghuber, D; Weihe, P; Weihrauch-Blüher, S; Wiegand, S, 2023)
" Multiple linear regression models were used to correlate changes in BCKAs, glutamate/glutamine and uric acid with changes in weight and insulin sensitivity as assessed by HOMA-IR, adiponectin and the ratio of triglyceride (TG) to HDL."8.31Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity. ( Armstrong, S; Bain, JR; Balikcioglu, M; Freemark, M; Gumus Balikcioglu, P; Ilkayeva, O; Jachthuber Trub, C; Muehlbauer, M; White, PJ, 2023)
" We investigated whether uric acid (UA) and the macrophage marker soluble form of cysteine scavenger receptor CD163 (sCD163) can be used as biomarkers for deteriorated metabolism or pediatric MAFLD in children with overweight or obesity."8.31Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity. ( Dalstrup Jakobsen, D; Kristensen, NM; Meldgaard Bruun, J; Orry, S, 2023)
"This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents."8.02Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents. ( Cai, W; Feng, Y; Mao, X; Niu, Y; Sheng, J; Tang, Q; Zhao, X, 2021)
"The relationships between uric acid (UA) and prediabetes is poorly explored in youth."8.02Uric acid, impaired fasting glucose and impaired glucose tolerance in youth with overweight and obesity. ( Baroni, MG; Campana, G; Chiesa, C; Del Giudice, EM; Di Bonito, P; Di Sessa, A; Licenziati, MR; Maffeis, C; Manco, M; Morandi, A; Pacifico, L; Valerio, G, 2021)
"There was a significant linear trend of increasing systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol, low-density lipoprotein cholesterol (LDLc), uric acid, insulin levels, and HOMA-IR index values corresponding with overweight and obese groups; however, high-density lipoprotein cholesterol (HDLc) levels decreased with increasing obesity."8.02High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle? ( de Araujo, PX; de Carvalho, BS; Franco, MDC; Thomazini, F, 2021)
"Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS)."7.85Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. ( Aronici, M; Bellone, S; Bona, G; Castagno, M; Di Mario, C; Genoni, G; Grossini, E; Martelli, M; Menegon, V; Monzani, A; Prodam, F; Ricotti, R; Secco, GG; Sonzini, M, 2017)
"Elevated serum uric acid (SUA) level is strongly associated with prevalence of metabolic syndrome (MS), elevated parathyroid hormone (PTH) levels, and 25-hydroxyvitamin D [25(OH)D] insufficiency in adults."7.83Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. ( Alemzadeh, R; Kichler, J, 2016)
"Increased xanthine oxidase (XO) activity and uric acid levels are known to be associated with obesity and hypertension; however, it is not known if obesity is directly responsible for these associations in youth."7.83Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity. ( Fox, CK; Johnson, LA; Kelly, AS; Nathan, BM; Tam, HK, 2016)
" To evaluate the association between uric acid levels and insulin resistance the Pearson's test and logistic regression were applied."7.81[The role of uric acid in the insulin resistance in children and adolescents with obesity]. ( Almeida, GG; Belo, VA; Cunha, MB; de Miranda, JA; dos Santos, JE; Lanna, CM; Martins, RI; Mourão-Júnior, CA, 2015)
"Hyperuricemia was common in youth with T2D."5.51Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu ( Bjornstad, P; El Ghormli, L; Laffel, L; Lynch, J; Nadeau, KJ; Tollefsen, SE; Weinstock, RS, 2019)
"Metabolic syndrome was defined according to the Adult Treatment Panel III criteria modified for children and adolescents."5.43Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study. ( Asayesh, H; Djalalinia, S; Eslami Shahr Babaki, A; Heshmat, R; Kelishadi, R; Motlagh, ME; Qorbani, M; Safari, O; Safiri, S; Tajadini, MH; Tajbakhsh, R, 2016)
"To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents."5.22Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance. ( Chan, TF; Huang, HL; Lee, CH; Lee, CY; Lin, WT; Tsai, S; Wang, TN; Wu, PW; Yang, YC, 2016)
" The current obesity epidemic has in fact made it relatively frequent even among children and adolescents to find some cardiovascular risk factors known in adults such as arterial hypertension, dyslipidemia, glucose metabolism disorders and increased of uric acid values."5.01Prevention of Cardiovascular Diseases in Children and Adolescents. ( Battaglino, MG; Genovesi, S; Giussani, M; Nava, E; Orlando, A; Parati, G, 2019)
"Associations between body mass index (BMI)- standard deviation score (SDS)/waist-to-height ratio (WHtR) were studied with (i) serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) and (ii) cardiometabolic risk markers in children with obesity, considering sex, pubertal development, and degree of weight loss/type of patient care."4.31Uric acid and gamma-glutamyl-transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the ( Bergjohann, L; Dannemann, A; Holl, RW; Leipold, G; Prinz, N; Reinehr, T; Weghuber, D; Weihe, P; Weihrauch-Blüher, S; Wiegand, S, 2023)
" Multiple linear regression models were used to correlate changes in BCKAs, glutamate/glutamine and uric acid with changes in weight and insulin sensitivity as assessed by HOMA-IR, adiponectin and the ratio of triglyceride (TG) to HDL."4.31Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity. ( Armstrong, S; Bain, JR; Balikcioglu, M; Freemark, M; Gumus Balikcioglu, P; Ilkayeva, O; Jachthuber Trub, C; Muehlbauer, M; White, PJ, 2023)
" Our aim was to identify the frequency of MHO in obese subjects, to assess the potential associations of demographic characteristics, serum uric acid, alanine transaminase (ALT), pediatric nonalcoholic fatty liver disease fibsosis score probability (PNFS p) with MHO status and to evaluate the differences between MHO and metabolically unhealthy obesity (MUO) with regard to metabolic syndrome surrogates."4.31Comparative analyses of surrogates of metabolic syndrome in children and adolescents with metabolically healthy obesity vs. metabolically unhealthy obesity according to Damanhoury's criteria. ( Ada, Hİ; Cakir, AD; Mohamad, R; Uçar, A, 2023)
" We investigated whether uric acid (UA) and the macrophage marker soluble form of cysteine scavenger receptor CD163 (sCD163) can be used as biomarkers for deteriorated metabolism or pediatric MAFLD in children with overweight or obesity."4.31Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity. ( Dalstrup Jakobsen, D; Kristensen, NM; Meldgaard Bruun, J; Orry, S, 2023)
"Subjects with insulin resistance (n = 101) showed significantly lower nocturnal melatonin levels compared to those with unimpaired insulin secretion (p = 0."4.12Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity. ( Kalveram, L; Keller, T; Krude, H; Kühnen, P; Overberg, J; Wiegand, S, 2022)
" We also tested whether the addition of an insulin resistance index (HOMA-index >90th percentile by sex and age) and the presence of hyperuricemia (serum uric acid >90th percentile by sex and age) to the definition of MUO better identified obese children with early cardiac damage."4.12Association of obesity phenotypes with left ventricular mass index and left ventricular hypertrophy in children and adolescents. ( Antolini, L; Genovesi, S; Giussani, M; Lieti, G; Montemerlo, M; Orlando, A; Parati, G; Patti, I; Tassistro, E, 2022)
"This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents."4.02Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents. ( Cai, W; Feng, Y; Mao, X; Niu, Y; Sheng, J; Tang, Q; Zhao, X, 2021)
"The relationships between uric acid (UA) and prediabetes is poorly explored in youth."4.02Uric acid, impaired fasting glucose and impaired glucose tolerance in youth with overweight and obesity. ( Baroni, MG; Campana, G; Chiesa, C; Del Giudice, EM; Di Bonito, P; Di Sessa, A; Licenziati, MR; Maffeis, C; Manco, M; Morandi, A; Pacifico, L; Valerio, G, 2021)
"We sought to explore the relationship between commonly used measures of insulin sensitivity/resistance (homeostatic model assessment index, serum uric acid, and triglycerides to high-density lipoprotein cholesterol ratio) and left ventricular geometry in normotensive obese children."4.02Insulin resistance surrogates and left ventricular hypertrophy in normotensive obese children. ( Bjelakovic, B; Bjelakovic, L; Bratic, M; Ciric, M; Lukic, S; Pantelic, S; Saranac, L; Stankovic, S; Vukovic, V, 2021)
"There was a significant linear trend of increasing systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol, low-density lipoprotein cholesterol (LDLc), uric acid, insulin levels, and HOMA-IR index values corresponding with overweight and obese groups; however, high-density lipoprotein cholesterol (HDLc) levels decreased with increasing obesity."4.02High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle? ( de Araujo, PX; de Carvalho, BS; Franco, MDC; Thomazini, F, 2021)
"To investigate the diagnostic role of combined salivary uric acid (UA), glucose and insulin levels to screen noninvasively for metabolic syndrome (MetS) and nonalcoholic fatty liver disease."3.91Salivary markers of hepato-metabolic comorbidities in pediatric obesity. ( Belmonte, F; Bisogno, A; Cavallo, P; Guercio Nuzio, S; Landolfi, A; Lausi, O; Marciano, F; Pierri, L; Troisi, J; Vajro, P, 2019)
"Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS)."3.85Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. ( Aronici, M; Bellone, S; Bona, G; Castagno, M; Di Mario, C; Genoni, G; Grossini, E; Martelli, M; Menegon, V; Monzani, A; Prodam, F; Ricotti, R; Secco, GG; Sonzini, M, 2017)
" Uric acid concentration associated with metabolic health when abdominal obesity was excluded."3.85Impact of dietary intake, lifestyle and biochemical factors on metabolic health in obese adolescents. ( Aldhoon-Hainerová, I; Hainer, V; Zamrazilová, H, 2017)
"Nonalcoholic fatty liver disease patients had significantly lower IGF-1 standard deviation score (IGF-1 SDS) and higher body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and uric acid levels than the control group."3.85Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents. ( Cheng, X; Hu, Y; Li, G; Liang, S; Song, R, 2017)
" The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized."3.85Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan. ( Komatsu, H; Kuwahara, E; Maejima, F; Murakami, Y; Nakazawa, A; Nishigaki, Y; Nishiwaki, Y; Okamura, T; Ushiku, H, 2017)
"Elevated serum uric acid (SUA) level is strongly associated with prevalence of metabolic syndrome (MS), elevated parathyroid hormone (PTH) levels, and 25-hydroxyvitamin D [25(OH)D] insufficiency in adults."3.83Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. ( Alemzadeh, R; Kichler, J, 2016)
"Increased xanthine oxidase (XO) activity and uric acid levels are known to be associated with obesity and hypertension; however, it is not known if obesity is directly responsible for these associations in youth."3.83Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity. ( Fox, CK; Johnson, LA; Kelly, AS; Nathan, BM; Tam, HK, 2016)
"High serum uric acid (SUA) levels are present in patients with metabolic syndrome (MetS), when the latter is associated with endothelial dysfunction, inflammation, and hypertension."3.81Association of serum uric acid levels to inflammation biomarkers and endothelial dysfunction in obese prepubertal children. ( Bermudo, F; Cañete, MD; Cañete, R; Martos, R; Valle, M; Valle, R; van Donkelaar, EL, 2015)
" To evaluate the association between uric acid levels and insulin resistance the Pearson's test and logistic regression were applied."3.81[The role of uric acid in the insulin resistance in children and adolescents with obesity]. ( Almeida, GG; Belo, VA; Cunha, MB; de Miranda, JA; dos Santos, JE; Lanna, CM; Martins, RI; Mourão-Júnior, CA, 2015)
"Childhood obesity is rapidly rising in China and effective diet interventions are needed."3.11Comparative dietary effectiveness of a modified government-recommended diet with avoidance of ultra-processed foods on weight and metabolic management in children and adolescents: An open-label, randomized study. ( Chen, F; Dong, G; Fu, J; Huang, K; Hui, CC; Long, Q; Ma, M; Ni, Y; Wu, W; Zhang, T, 2022)
"The current childhood obesity pandemic is likely to result in an increased risk of chronic kidney disease (CKD) later in life."1.91Relation between obesity-related comorbidities and kidney function estimation in children. ( Pottel, H; van Dam, MJCM; Vreugdenhil, ACE, 2023)
"Background The prevalence of childhood obesity and its related comorbidities in Malaysia are alarming."1.56Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity. ( Anuar Zaini, A; Jalaludin, MY; Mohamed, RZ, 2020)
"Hyperuricemia was common in youth with T2D."1.51Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu ( Bjornstad, P; El Ghormli, L; Laffel, L; Lynch, J; Nadeau, KJ; Tollefsen, SE; Weinstock, RS, 2019)
"Although MS and NAFLD were more prevalent in adolescents, young children also demonstrated MS and NAFLD as obesity-related complications."1.48Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity. ( Cho, J; Kim, JY; Yang, HR, 2018)
"Uric acid is a powerful determinant of blood pressure over time, independent of lifestyle modifications."1.43Increased Serum Uric Acid Levels Blunt the Antihypertensive Efficacy of Lifestyle Modifications in Children at Cardiovascular Risk. ( Antolini, L; Genovesi, S; Giussani, M; Orlando, A; Pontremoli, R; Rebora, P; Stella, A; Valsecchi, MG; Viazzi, F, 2016)
"Metabolic syndrome was defined according to the Adult Treatment Panel III criteria modified for children and adolescents."1.43Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study. ( Asayesh, H; Djalalinia, S; Eslami Shahr Babaki, A; Heshmat, R; Kelishadi, R; Motlagh, ME; Qorbani, M; Safari, O; Safiri, S; Tajadini, MH; Tajbakhsh, R, 2016)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's23 (52.27)24.3611
2020's21 (47.73)2.80

Authors

AuthorsStudies
Cho, AY1
Roh, JG1
Shim, YS1
Lee, HS1
Hwang, JS1
Kalay Senturk, NG1
Dagdeviren Cakir, A1
Yildirmak, ZY1
Ucar, A2
Niu, Y1
Tang, Q1
Zhao, X2
Mao, X1
Sheng, J1
Cai, W1
Feng, Y1
Overberg, J1
Kalveram, L1
Keller, T1
Krude, H1
Kühnen, P1
Wiegand, S2
Chen, F1
Huang, K1
Long, Q1
Ma, M1
Zhang, T2
Dong, G1
Wu, W1
Ni, Y1
Hui, CC1
Fu, J1
Erazmus, M1
Rumińska, M2
Witkowska-Sędek, E2
Kucharska, AM2
Stelmaszczyk-Emmel, A2
Majcher, A2
Pyrżak, B2
Genovesi, S3
Tassistro, E1
Giussani, M3
Lieti, G1
Patti, I1
Orlando, A3
Montemerlo, M1
Antolini, L2
Parati, G2
Weihrauch-Blüher, S1
Weihe, P1
Prinz, N1
Weghuber, D1
Leipold, G1
Dannemann, A1
Bergjohann, L1
Reinehr, T1
Holl, RW1
Gumus Balikcioglu, P3
Jachthuber Trub, C3
Balikcioglu, M3
Ilkayeva, O3
White, PJ3
Muehlbauer, M3
Bain, JR3
Armstrong, S3
Freemark, M3
van Dam, MJCM3
Pottel, H3
Vreugdenhil, ACE3
Mohamad, R1
Cakir, AD1
Ada, Hİ1
Serret-Montoya, J1
Zurita-Cruz, JN1
Villasís-Keever, MÁ1
López-Beltrán, AL1
Espíritu-Díaz, ME1
Delgadillo-Ruano, MA1
Gómez-Alba, M1
Mendoza-Rojas, O1
Krajewska, M1
Sobol, M1
Orry, S1
Dalstrup Jakobsen, D1
Kristensen, NM1
Meldgaard Bruun, J1
Bjelakovic, B2
Stefanutti, C1
Bonic, D1
Vukovic, V2
Kavaric, N1
Saranac, L2
Kocic, G1
Klisic, A1
Jevtović Stojmenov, T1
Lukic, S2
Jovic, M1
Bjelakovic, M1
Mohamed, RZ1
Jalaludin, MY1
Anuar Zaini, A1
Zurita-Cruz, J1
Villasis-Keever, M1
Manuel-Apolinar, L1
Damasio-Santana, L1
Wakida-Kusunoki, GH1
Padilla-Rojas, M1
Maldonado-Rivera, C1
Chiu, S1
Siri-Tarino, P1
Bergeron, N1
Suh, JH1
Krauss, RM1
Vidanapathirana, DM1
Samaranayake, D1
Wickramasinghe, P1
Di Bonito, P1
Valerio, G1
Licenziati, MR1
Campana, G1
Del Giudice, EM1
Di Sessa, A1
Morandi, A1
Maffeis, C1
Chiesa, C1
Pacifico, L1
Baroni, MG1
Manco, M2
Bjelakovic, L1
Stankovic, S1
Ciric, M1
Bratic, M1
Pantelic, S1
Yun, M1
Li, S1
Wang, X1
Fan, L1
Yan, Y1
Bazzano, L1
He, J1
Chen, W1
Thomazini, F1
de Carvalho, BS1
de Araujo, PX1
Franco, MDC1
Aldhoon-Hainerová, I1
Hainer, V1
Zamrazilová, H1
Genoni, G2
Menegon, V1
Secco, GG1
Sonzini, M1
Martelli, M1
Castagno, M2
Ricotti, R2
Monzani, A2
Aronici, M1
Grossini, E1
Di Mario, C1
Bona, G2
Bellone, S2
Prodam, F2
Giglione, E1
Nugnes, M1
Zanetta, S1
Marolda, A1
Bellomo, G1
Kim, JY1
Cho, J1
Yang, HR1
Rocha, EPAA1
Vogel, M1
Stanik, J1
Pietzner, D1
Willenberg, A1
Körner, A1
Kiess, W1
Troisi, J1
Belmonte, F1
Bisogno, A1
Lausi, O1
Marciano, F1
Cavallo, P1
Guercio Nuzio, S1
Landolfi, A1
Pierri, L1
Vajro, P1
Bjornstad, P1
Laffel, L1
Lynch, J1
El Ghormli, L1
Weinstock, RS1
Tollefsen, SE1
Nadeau, KJ1
Battaglino, MG1
Nava, E1
Oberbach, A1
Neuhaus, J1
Inge, T1
Kirsch, K1
Schlichting, N1
Blüher, S1
Kullnick, Y1
Kugler, J1
Baumann, S1
Till, H1
Gómez García, A1
Núñez, GG1
Sandoval, ME1
Castellanos, SG1
Alvarez Aguilar, C1
Bindler, RC1
Daratha, KB1
Bindler, RJ1
Short, R1
Valle, M1
Martos, R1
Cañete, MD1
Valle, R1
van Donkelaar, EL1
Bermudo, F1
Cañete, R1
de Miranda, JA1
Almeida, GG1
Martins, RI1
Cunha, MB1
Belo, VA1
dos Santos, JE1
Mourão-Júnior, CA1
Lanna, CM1
Lin, WT1
Chan, TF1
Huang, HL1
Lee, CY1
Tsai, S1
Wu, PW1
Yang, YC1
Wang, TN1
Lee, CH1
Alemzadeh, R1
Kichler, J1
Tam, HK1
Kelly, AS1
Fox, CK1
Nathan, BM1
Johnson, LA1
Viazzi, F1
Rebora, P1
Stella, A1
Valsecchi, MG1
Pontremoli, R1
Safiri, S1
Qorbani, M1
Heshmat, R1
Tajbakhsh, R1
Eslami Shahr Babaki, A1
Djalalinia, S1
Motlagh, ME1
Tajadini, MH1
Asayesh, H1
Safari, O1
Kelishadi, R1
Liang, S1
Cheng, X1
Hu, Y1
Song, R1
Li, G1
Luciano, R1
Shashaj, B1
Spreghini, M1
Del Fattore, A1
Rustico, C1
Wietrzykowska Sforza, R1
Morino, GS1
Dallapiccola, B1
Kuwahara, E1
Murakami, Y1
Okamura, T1
Komatsu, H1
Nakazawa, A1
Ushiku, H1
Maejima, F1
Nishigaki, Y1
Nishiwaki, Y1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial[NCT00081328]Phase 3699 participants (Actual)Interventional2004-05-31Completed
Paediatric Obesity and Cardiovascular Dysfunction: Searching for Early Markers of Damage[NCT03169257]100 participants (Actual)Interventional2015-01-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Body Composition -- BMI

Body mass index (BMI) measured in kg per meters squared. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months

Interventionkg per meters squared (Mean)
1 Metformin Alone36.7
2 Metformin + Rosliglitazone38.2
3 Metformin + Lifestyle Program35.3

Body Composition -- Bone Density

Measured by DXA, both whole body scan and AP-spine scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months

Interventiong/cm squared (Mean)
1 Metformin Alone1.15
2 Metformin + Rosliglitazone1.15
3 Metformin + Lifestyle Program1.15

Body Composition -- Fat Mass

Determined by DXA whole body scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months

Interventionkg (Mean)
1 Metformin Alone36.1
2 Metformin + Rosliglitazone39.7
3 Metformin + Lifestyle Program32.2

Body Composition -- Waist Circumference

Waist circumference (cm) measured at the iliac crest at its outermost point with the measuring tape placed around the participant in a horizontal plane parallel to the floor at the mark and the measurement teken at the end of normal expiration without the tape compressing the skin. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months

Interventioncm (Mean)
1 Metformin Alone110.8
2 Metformin + Rosliglitazone114.0
3 Metformin + Lifestyle Program108.6

Comorbidity -- Hypertension

A diagnosis was made by an out-of-range value >=95th percentile or systolic >=130 or diastolic >=80 sustained over 6 months or on an anti-hypertensive medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.

Interventionparticipants (Number)
1 Metformin Alone57
2 Metformin + Rosliglitazone53
3 Metformin + Lifestyle Program45

Comorbidity -- LDL Dyslipidemia

A diagnosis was made from out-of-range value >= 130 mg/dL sustained over 6 months or put on lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.

Interventionparticipants (Number)
1 Metformin Alone18
2 Metformin + Rosliglitazone16
3 Metformin + Lifestyle Program15

Comorbidity -- Triglycerides Dyslipidemia

A diagnosis was made by an out-of-range value >=150 mg/dL sustained over 6 months or on appropriate lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.

Interventionparticipants (Number)
1 Metformin Alone20
2 Metformin + Rosliglitazone28
3 Metformin + Lifestyle Program22

Insulin Secretion

Insulinogenic index determined from OGTT as difference in insulin at 30 minutes minus 0 minutes divided by difference in glucose at 30 minutes minus 0 minutes. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months

InterventionuU/mL divided by mg/dL (Median)
1 Metformin Alone.75
2 Metformin + Rosliglitazone.83
3 Metformin + Lifestyle Program.71

Insulin Sensitivity

All participants were followed to 24 months. Insulin sensitivity is measured from OGTT as inverse of fasting insulin (mL/uU). The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months

InterventionmL/uU (Median)
1 Metformin Alone0.037
2 Metformin + Rosiglitazone0.049
3 Metformin + Lifestyle Program0.039

Number of Serious Adverse Events

Number of serious adverse events reported during the trial. Participant could have multiple episodes reported. (NCT00081328)
Timeframe: Reported as occurred during study follow-up - 2 years to 6.5 years from randomization.

Interventionepisodes of serious adverse event (Number)
1 Metformin Alone42
2 Metformin + Rosiglitazone34
3 Metformin + Lifestyle Program58

Treatment Failure (Loss of Glycemic Control)

Defined as A1c persistently >=8% over a 6-month period or persistent metabolic decompensation (inability to wean insulin within 3 months of initiation or the occurrence of a second episode within three months of discontinuing insulin) (NCT00081328)
Timeframe: Study duration - 2 years to 6.5 years of follow up from randomization

,,
Interventionparticipants (Number)
Treatment failureDid not fail treatment during trial
1 Metformin Alone120112
2 Metformin + Rosliglitazone90143
3 Metformin + Lifestyle Program109125

Reviews

1 review available for uric acid and Adolescent Obesity

ArticleYear
Prevention of Cardiovascular Diseases in Children and Adolescents.
    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2019, Volume: 26, Issue:3

    Topics: Adolescent; Age of Onset; Arterial Pressure; Biomarkers; Blood Glucose; Cardiovascular Diseases; Chi

2019

Trials

4 trials available for uric acid and Adolescent Obesity

ArticleYear
Comparative dietary effectiveness of a modified government-recommended diet with avoidance of ultra-processed foods on weight and metabolic management in children and adolescents: An open-label, randomized study.
    Asia Pacific journal of clinical nutrition, 2022, Volume: 31, Issue:2

    Topics: Adolescent; Body Mass Index; Child; Child, Preschool; Diet; Glucose; Government; Humans; Insulin; Ov

2022
A Randomized Study of the Effect of Replacing Sugar-Sweetened Soda by Reduced Fat Milk on Cardiometabolic Health in Male Adolescent Soda Drinkers.
    Nutrients, 2020, Feb-04, Volume: 12, Issue:2

    Topics: Adolescent; Animals; Blood Pressure; Carbonated Beverages; Cardiovascular Diseases; Drinking; Dyslip

2020
Serum Uric Acid Levels as an Indicator for Metabolically Unhealthy Obesity in Children and Adolescents.
    Hormone research in paediatrics, 2018, Volume: 90, Issue:1

    Topics: Adolescent; Blood Glucose; Blood Pressure; Child; Fasting; Female; Humans; Lipids; Male; Pediatric O

2018
Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance.
    The Journal of pediatrics, 2016, Volume: 171

    Topics: Adolescent; Anthropometry; Beverages; Biomarkers; Child; Cross-Sectional Studies; Feeding Behavior;

2016

Other Studies

39 other studies available for uric acid and Adolescent Obesity

ArticleYear
Biochemical predictors of metabolically unhealthy obesity in children and adolescents.
    Journal of pediatric endocrinology & metabolism : JPEM, 2022, Jan-27, Volume: 35, Issue:1

    Topics: Adolescent; Child; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Obesity, Metabo

2022
Assessment of Serum Spexin Levels in Obese Adolescents with Metabolic Syndrome Antecedents: Preliminary Results.
    Hormone research in paediatrics, 2021, Volume: 94, Issue:9-10

    Topics: Adolescent; Child; Humans; Insulin; Insulin Resistance; Metabolic Syndrome; Pediatric Obesity; Uric

2021
Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Adolescent; Body Mass Index; Child; Child, Preschool; Female; Humans; Insulin; Insulin Resistance; M

2021
Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity.
    International journal of obesity (2005), 2022, Volume: 46, Issue:5

    Topics: Adolescent; Child; Circadian Rhythm; Cross-Sectional Studies; Humans; Insulin Resistance; Melatonin;

2022
Decreased level of soluble receptor activator of nuclear factor-κβ ligand (sRANKL) in overweight and obese children.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adolescent; Child; Humans; Ligands; Osteogenesis; Osteoprotegerin; Overweight; Pediatric Obesity; RA

2022
Association of obesity phenotypes with left ventricular mass index and left ventricular hypertrophy in children and adolescents.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Child; Female; Humans; Hypertrophy, Left Ventricular; Hyperuricemia; Insulin Resistance; Male; Metab

2022
Uric acid and gamma-glutamyl-transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the
    Pediatric obesity, 2023, Volume: 18, Issue:3

    Topics: Adiposity; Adolescent; Body Mass Index; Cardiovascular Diseases; Child; Female; Follow-Up Studies; g

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
    Endocrinology, diabetes & metabolism, 2023, Volume: 6, Issue:1

    Topics: Adiponectin; Adolescent; Biomarkers; Child; Chromatography, Liquid; Female; Glutamates; Glutamine; H

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Relation between obesity-related comorbidities and kidney function estimation in children.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Adolescent; Biomarkers; Child; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Ra

2023
Comparative analyses of surrogates of metabolic syndrome in children and adolescents with metabolically healthy obesity vs. metabolically unhealthy obesity according to Damanhoury's criteria.
    Journal of pediatric endocrinology & metabolism : JPEM, 2023, May-25, Volume: 36, Issue:5

    Topics: Body Mass Index; Child; Female; Humans; Hyperuricemia; Metabolic Syndrome; Obesity, Metabolically Be

2023
[Correlation of uric acid with carotid intima media thickness in obese adolescents].
    Nutricion hospitalaria, 2023, Jun-21, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Body Mass Index; Carotid Intima-Media Thickness; Child; Cross-Sectional Studies;

2023
The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Adolescent; Body Mass Index; Child; Humans; Insulin; Metabolome; Overweight; Pediatric Obesity; Pros

2023
Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity.
    Journal of pediatric endocrinology & metabolism : JPEM, 2023, Jul-26, Volume: 36, Issue:7

    Topics: Adolescent; Biomarkers; Child; Cross-Sectional Studies; Humans; Non-alcoholic Fatty Liver Disease; O

2023
Serum uric acid and left ventricular geometry pattern in obese children.
    Atherosclerosis. Supplements, 2019, Volume: 40

    Topics: Adolescent; Case-Control Studies; Child; Cross-Sectional Studies; Female; Humans; Hypertrophy, Left

2019
Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity.
    Journal of pediatric endocrinology & metabolism : JPEM, 2020, Feb-25, Volume: 33, Issue:2

    Topics: Adolescent; Alanine Transaminase; Biomarkers; Blood Glucose; Body Mass Index; Case-Control Studies;

2020
Resistin/Uric Acid Index as a Prognostic Factor in Adolescents with Obesity after Lifestyle Intervention.
    The Journal of pediatrics, 2020, Volume: 219

    Topics: Adolescent; Biomarkers; Body Mass Index; Child; Cognitive Behavioral Therapy; Exercise; Female; Huma

2020
Association of Serum Uric acid and Gamma-glutamyltransferase with Obesity Related Metabolic Derangements in a Cohort of Children with Obesity in Sri Lanka
    The Ceylon medical journal, 2019, Dec-31, Volume: 64, Issue:4

    Topics: Adolescent; Biomarkers; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cross-Sectional St

2019
Uric acid, impaired fasting glucose and impaired glucose tolerance in youth with overweight and obesity.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2021, 02-08, Volume: 31, Issue:2

    Topics: Adolescent; Age Factors; Biomarkers; Blood Glucose; Child; Child, Preschool; Cross-Sectional Studies

2021
Insulin resistance surrogates and left ventricular hypertrophy in normotensive obese children.
    Cardiology in the young, 2021, Volume: 31, Issue:12

    Topics: Child; Cross-Sectional Studies; Humans; Hypertrophy, Left Ventricular; Insulin Resistance; Pediatric

2021
Temporal relationship between body mass index and uric acid and their joint impact on blood pressure in children and adults: the Bogalusa Heart Study.
    International journal of obesity (2005), 2021, Volume: 45, Issue:7

    Topics: Adolescent; Adult; Blood Pressure; Body Mass Index; Child; Child, Preschool; Female; Humans; Hyperte

2021
High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle?
    Journal of pediatric endocrinology & metabolism : JPEM, 2021, Nov-25, Volume: 34, Issue:11

    Topics: Blood Pressure; Body Mass Index; Cardiometabolic Risk Factors; Child; Creatinine; Female; Humans; In

2021
Impact of dietary intake, lifestyle and biochemical factors on metabolic health in obese adolescents.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2017, Volume: 27, Issue:8

    Topics: Adolescent; Alanine Transaminase; Biomarkers; C-Reactive Protein; Czech Republic; Diet; Diet, Health

2017
Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity.
    International journal of cardiology, 2017, Dec-15, Volume: 249

    Topics: Adolescent; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Child; Female; Humans; Insuli

2017
High-normal estimated glomerular filtration rate and hyperuricemia positively correlate with metabolic impairment in pediatric obese patients.
    PloS one, 2018, Volume: 13, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Glomerular Filtration Rate; Humans; Hy

2018
Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity.
    Journal of Korean medical science, 2018, Apr-16, Volume: 33, Issue:16

    Topics: Adolescent; Age of Onset; Anthropometry; Blood Pressure; Child; Child, Preschool; Cholesterol; Femal

2018
Salivary markers of hepato-metabolic comorbidities in pediatric obesity.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2019, Volume: 51, Issue:4

    Topics: Adolescent; Biomarkers; Child; Comorbidity; Female; Glucose; Homeostasis; Humans; Insulin; Insulin R

2019
Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu
    Diabetes care, 2019, Volume: 42, Issue:6

    Topics: Adolescent; Blood Pressure; Child; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephro

2019
Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia.
    Metabolism: clinical and experimental, 2014, Volume: 63, Issue:2

    Topics: Adolescent; Bariatric Surgery; Biomarkers; Case-Control Studies; Child; Comorbidity; Female; Gastric

2014
Factors associated with early platelet activation in obese children.
    Clinical medicine & research, 2014, Volume: 12, Issue:1-2

    Topics: Blood Glucose; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies;

2014
Serum uric acid: relationships with biomarkers in adolescents and changes over 1 year.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Adolescent; Aging; Anthropometry; Biomarkers; Body Weight; Female; Heart Diseases; Humans; Longitudi

2014
Association of serum uric acid levels to inflammation biomarkers and endothelial dysfunction in obese prepubertal children.
    Pediatric diabetes, 2015, Volume: 16, Issue:6

    Topics: Biomarkers; Body Mass Index; C-Reactive Protein; Child; Cross-Sectional Studies; Endothelium, Vascul

2015
[The role of uric acid in the insulin resistance in children and adolescents with obesity].
    Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2015, Volume: 33, Issue:4

    Topics: Adolescent; Blood Pressure; Body Height; Body Mass Index; Body Weight; Child; Cross-Sectional Studie

2015
Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents.
    Metabolic syndrome and related disorders, 2016, Volume: 14, Issue:3

    Topics: Adolescent; Female; Humans; Inflammation; Male; Metabolic Syndrome; Parathyroid Hormone; Pediatric O

2016
Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.
    Childhood obesity (Print), 2016, Volume: 12, Issue:4

    Topics: Adolescent; Blood Pressure; Caloric Restriction; Female; Humans; Hypertension; Male; Minnesota; Obes

2016
Increased Serum Uric Acid Levels Blunt the Antihypertensive Efficacy of Lifestyle Modifications in Children at Cardiovascular Risk.
    Hypertension (Dallas, Tex. : 1979), 2016, Volume: 67, Issue:5

    Topics: Anthropometry; Antihypertensive Agents; Biomarkers; Blood Pressure; Blood Pressure Determination; Bo

2016
Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study.
    Iranian journal of kidney diseases, 2016, Volume: 10, Issue:3

    Topics: Adolescent; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Child; Cross-Sectional S

2016
Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents.
    Acta paediatrica (Oslo, Norway : 1992), 2017, Volume: 106, Issue:2

    Topics: Adolescent; Biomarkers; Body Mass Index; Child; Cross-Sectional Studies; Female; Humans; Insulin Res

2017
Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents.
    Italian journal of pediatrics, 2017, Jan-03, Volume: 43, Issue:1

    Topics: Adolescent; Biomarkers; Body Mass Index; Cardiovascular Diseases; Child; Child, Preschool; Cross-Sec

2017
Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan.
    Pediatric research, 2017, Volume: 81, Issue:2

    Topics: Adult; Anthropometry; Body Mass Index; Child; Coronary Disease; Female; Humans; Hypertension; Japan;

2017